May‐Britt Moser, David C Rowland, Edvard I Moser,
... of Science and Technology, 7489 Trondheim, Norway Correspondence: edvard.moser{at}ntnu.no
Tópico(s): Neuroscience and Neuropharmacology Research
2015 - Cold Spring Harbor Laboratory Press | Cold Spring Harbor Perspectives in Biology
Kei M. Igarashi, Li Lu, Laura L Colgin, May‐Britt Moser, Edvard I Moser,
... nature of such communications are still unknown. Here, Edvard Moser and colleagues simultaneously record from hippocampus and entorhinal ...
Tópico(s): Sleep and Wakefulness Research
2014 - Nature Portfolio | Nature
Emilio Kropff, James E. Carmichael, May‐Britt Moser, Edvard I Moser,
... speed information has not been previously identified. Here, Edvard Moser and colleagues isolate a specific class of neurons ...
Tópico(s): Neuroscience and Neuropharmacology Research
2015 - Nature Portfolio | Nature
... properties of the stimulus. When May-Britt and Edvard Moser entered the field, they focused on analyzing how ... PubMed Scopus (380) Google Scholar). May-Britt and Edvard Moser were students of Per Andersen, an early pioneer ... of the Center for Neural Computation in Trondheim. Edvard I. Moser is Director of the Kavli Institute for Systems Neuroscience in Trondheim.Edvard I. Moser. Image courtesy of Geir Mogen/NTNU.View Large ...
Tópico(s): Sleep and Wakefulness Research
2014 - Cell Press | Cell
György Buzsáki, Edvard I Moser,
In this review, György Buzsáki and Edvard Moser discuss the most recent evidence suggesting that the navigation and memory functions of the hippocampus and entorhinal cortex are supported by the ...
Tópico(s): Sleep and Wakefulness Research
2013 - Nature Portfolio | Nature Neuroscience
Nobel prizewinners May-Britt Moser and Edvard Moser have spent a career together near the Arctic Circle exploring how our brains know where we are.
Tópico(s): Mitochondrial Function and Pathology
2014 - Nature Portfolio | Nature
Halle R. Dimsdale-Zucker, Charan Ranganath,
... Professors John O'Keefe, May-Britt Moser, and Edvard Moser brings global recognition to one of the most ...
Tópico(s): Stress Responses and Cortisol
2015 - Wiley | Hippocampus
Michael E. Hasselmo, Chantal E. Stern,
... John O'Keefe and May-Britt Moser and Edvard Moser. These findings provided an essential foothold for understanding ...
Tópico(s): Neural dynamics and brain function
2015 - Wiley | Hippocampus
Christian F. Doeller, Caswell Barry, Neil Burgess,
The discovery by Edvard Moser and colleagues that rats and mice possess an orientation map of their surroundings, produced and updated by a network ...
Tópico(s): Neural dynamics and brain function
2010 - Nature Portfolio | Nature
Julija Krupic, Marius Bauža, Stephen Burton, Caswell Barry, John O’Keefe,
... papers in this issue of Nature — one from Edvard Moser and colleagues and the other from John O' ...
Tópico(s): Photoreceptor and optogenetics research
2015 - Nature Portfolio | Nature
... findings from the laboratory of May-Britt and Edvard Moser (Tsao et al. in Nature 561, 57–62, ...
Tópico(s): Sleep and Wakefulness Research
2019 - Springer Science+Business Media | Learning & Behavior
... Laureates in Physiology or Medicine, John O’Keefe, Edvard Moser, and May-Britt Moser, have worked to explain ...
Tópico(s): Spatial Cognition and Navigation
2015 - Taylor & Francis | Science & Technology Libraries
May‐Britt Moser, Edvard I Moser, Boaz Wultz, Terje Sagvolden,
The present study investigated behaviour in a two‐compartment free‐exploration open field by means of a component analysis. Seven spontaneously hypertensive rats (SHR) and six normotensive Wistar Kyoto control rats (WKY) were tested repeatedly on eight behaviour parameters in this apparatus. A two‐compartment free‐exploration open field evokes less fear than the standard one‐compartment forced‐exploration open field, because it permits the rat to enter the field from its home cage. The data were subjected ...
Tópico(s): Behavioral and Psychological Studies
1988 - Wiley | Scandinavian Journal of Psychology
Dori Derdikman, Jonathan R. Whitlock, Albert Tsao, Marianne Fyhn, Torkel Hafting, May‐Britt Moser, Edvard I Moser,
Tópico(s): Sleep and Wakefulness Research
2009 - Nature Portfolio | Nature Neuroscience
Laura L Colgin, Tobias Denninger, Marianne Fyhn, Torkel Hafting, Tora Bonnevie, Ole Jensen, May‐Britt Moser, Edvard I Moser,
Tópico(s): Neural dynamics and brain function
2009 - Nature Portfolio | Nature
Marianne Fyhn, Sturla Molden, Stig Hollup, May‐Britt Moser, Edvard I Moser,
To examine how hippocampal neurons respond to a mismatch between retrieved and actual experience, we trained rats to find a hidden platform at a particular location in an annular watermaze and then moved the platform. Several cells that were silent at the new platform location before the move fired vigorously when the rat found the goal. The new activity was paralleled by reduced discharge in a subset of simultaneously recorded interneurons. The pattern of activity returned toward its original configuration ...
Tópico(s): Sleep and Wakefulness Research
2002 - Cell Press | Neuron
Vegard Heimly Brun, Mona K. Otnæss, Sturla Molden, Hill-Aina Steffenach, Menno P. Witter, May‐Britt Moser, Edvard I Moser,
Place cells in hippocampal area CA1 may receive positional information from the intrahippocampal associative network in area CA3 or directly from the entorhinal cortex. To determine whether direct entorhinal connections support spatial firing and spatial memory, we removed all input from areas CA3 to CA1, thus isolating the CA1 area. Pyramidal cells in the isolated CA1 area developed sharp and stable place fields. Rats with an isolated CA1 area showed normal acquisition of an associative hippocampal- ...
Tópico(s): Zebrafish Biomedical Research Applications
2002 - American Association for the Advancement of Science | Science
Frode A. Tuvnes, Hill-Aina Steffenach, Robert Murison, May‐Britt Moser, Edvard I Moser,
It has been proposed that the hippocampus exerts a tonic inhibitory influence on the hypothalamic–pituitary–adrenal (HPA) stress axis. This claim rests, in particular, on the upregulation of corticosterone secretion and other measures of HPA activity after nonselective lesions of the hippocampal formation. We measured plasma corticosterone concentrations after selective neurotoxic damage to the hippocampus and the subiculum in rats. Concentrations were estimated during rest in the rat's home cage ...
Tópico(s): Neuroendocrine regulation and behavior
2003 - Society for Neuroscience | Journal of Neuroscience
Trygve Solstad, Claude Boccara, Emilio Kropff, May‐Britt Moser, Edvard I Moser,
We report the existence of an entorhinal cell type that fires when an animal is close to the borders of the proximal environment. The orientation-specific edge-apposing activity of these "border cells" is maintained when the environment is stretched and during testing in enclosures of different size and shape in different rooms. Border cells are relatively sparse, making up less than 10% of the local cell population, but can be found in all layers of the medial entorhinal cortex as well as the adjacent ...
Tópico(s): Neurogenesis and neuroplasticity mechanisms
2008 - American Association for the Advancement of Science | Science
Torkel Hafting, Marianne Fyhn, Tora Bonnevie, May‐Britt Moser, Edvard I Moser,
Tópico(s): Neural dynamics and brain function
2008 - Nature Portfolio | Nature
Jonathan R. Whitlock, Robert J. Sutherland, Menno P. Witter, May‐Britt Moser, Edvard I Moser,
The navigational system of the mammalian cortex comprises a number of interacting brain regions. Grid cells in the medial entorhinal cortex and place cells in the hippocampus are thought to participate in the formation of a dynamic representation of the animal's current location, and these cells are presumably critical for storing the representation in memory. To traverse the environment, animals must be able to translate coordinate information from spatial maps in the entorhinal cortex and hippocampus ...
Tópico(s): Neuroscience and Neuropharmacology Research
2008 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Espen J. Henriksen, Laura L Colgin, Carol A. Barnes, Menno P. Witter, May‐Britt Moser, Edvard I Moser,
CA1 cells receive direct input from space-responsive cells in medial entorhinal cortex (MEC), such as grid cells, as well as more nonspatial cells in lateral entorhinal cortex (LEC). Because MEC projects preferentially to the proximal part of the CA1, bordering CA2, whereas LEC innervates only the distal part, bordering subiculum, we asked if spatial tuning is graded along the transverse axis of CA1. Tetrodes were implanted along the entire proximodistal axis of dorsal CA1 in rats. Data were recorded ...
Tópico(s): Stress Responses and Cortisol
2010 - Cell Press | Neuron
Marianne Fyhn, Torkel Hafting, Alessandro Treves, May‐Britt Moser, Edvard I Moser,
Tópico(s): Olfactory and Sensory Function Studies
2007 - Nature Portfolio | Nature
Jill K. Leutgeb, Stefan Leutgeb, May‐Britt Moser, Edvard I Moser,
Theoretical models have long pointed to the dentate gyrus as a possible source of neuronal pattern separation. In agreement with predictions from these models, we show that minimal changes in the shape of the environment in which rats are exploring can substantially alter correlated activity patterns among place-modulated granule cells in the dentate gyrus. When the environments are made more different, new cell populations are recruited in CA3 but not in the dentate gyrus. These results imply a ...
Tópico(s): Neurogenesis and neuroplasticity mechanisms
2007 - American Association for the Advancement of Science | Science
Lisa M. Giocomo, May‐Britt Moser, Edvard I Moser,
Grid cells are space-modulated neurons with periodic firing fields. In moving animals, the multiple firing fields of an individual grid cell form a triangular pattern tiling the entire space available to the animal. Collectively, grid cells are thought to provide a context-independent metric representation of the local environment. Since the discovery of grid cells in 2005, a number of models have been proposed to explain the formation of spatially repetitive firing patterns as well as the conversion ...
Tópico(s): Neuroscience and Neuropharmacology Research
2011 - Cell Press | Neuron
Lisa M. Giocomo, S. Abid Hussaini, Zheng Fan, Eric R. Kandel, May‐Britt Moser, Edvard I Moser,
Entorhinal grid cells have periodic, hexagonally patterned firing locations that scale up progressively along the dorsal-ventral axis of medial entorhinal cortex. This topographic expansion corresponds with parallel changes in cellular properties dependent on the hyperpolarization-activated cation current (Ih), which is conducted by hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. To test the hypothesis that grid scale is determined by Ih, we recorded grid cells in mice with forebrain- ...
Tópico(s): Neuroendocrine regulation and behavior
2011 - Cell Press | Cell
Francesca Sargolini, Marianne Fyhn, Torkel Hafting, Bruce L. McNaughton, Menno P. Witter, May‐Britt Moser, Edvard I Moser,
Grid cells in the medial entorhinal cortex (MEC) are part of an environment-independent spatial coordinate system. To determine how information about location, direction, and distance is integrated in the grid-cell network, we recorded from each principal cell layer of MEC in rats that explored two-dimensional environments. Whereas layer II was predominated by grid cells, grid cells colocalized with head-direction cells and conjunctive grid x head-direction cells in the deeper layers. All cell types ...
Tópico(s): Sleep and Wakefulness Research
2006 - American Association for the Advancement of Science | Science
Jonathan R. Whitlock, Gerit Pfuhl, Nenitha C. Dagslott, May‐Britt Moser, Edvard I Moser,
Posterior parietal cortex (PPC) and medial entorhinal cortex (MEC) are important elements of the neural circuit for space, but whether representations in these areas are controlled by the same factors is unknown. We recorded single units simultaneously in PPC and MEC of freely foraging rats and found that a subset of PPC cells are tuned to specific modes of movement irrespective of the animals' location or heading, whereas grid cells in MEC expressed static spatial maps. The behavioral correlates ...
Tópico(s): Sleep and Wakefulness Research
2012 - Cell Press | Neuron
Hanne Stensola, Tor Stensola, Trygve Solstad, Kristian Frøland, May‐Britt Moser, Edvard I Moser,
Tópico(s): Neural dynamics and brain function
2012 - Nature Portfolio | Nature
Stefan Leutgeb, Jill K. Leutgeb, May‐Britt Moser, Edvard I Moser,
The study of population dynamics in hippocampal place cells has emerged as one of the most powerful tools for understanding the encoding, storage and retrieval of declarative memory. Recent work has laid out the contours of an attractor-based hippocampal population code for memory in recurrent circuits of the hippocampus. The code is based on inputs from a topographically organized, path-integration-dependent spatial map that lies upstream in the medial entorhinal cortex. The recurrent networks ...
Tópico(s): Neuroinflammation and Neurodegeneration Mechanisms
2005 - Elsevier BV | Current Opinion in Neurobiology