May‐Britt Moser, David C Rowland, Edvard I Moser,
... of Science and Technology, 7489 Trondheim, Norway Correspondence: edvard.moser{at}ntnu.no
Tópico(s): Neuroscience and Neuropharmacology Research
2015 - Cold Spring Harbor Laboratory Press | Cold Spring Harbor Perspectives in Biology
Emilio Kropff, James E. Carmichael, May‐Britt Moser, Edvard I Moser,
... speed information has not been previously identified. Here, Edvard Moser and colleagues isolate a specific class of neurons ...
Tópico(s): Neuroscience and Neuropharmacology Research
2015 - Nature Portfolio | Nature
Kei M. Igarashi, Li Lu, Laura L Colgin, May‐Britt Moser, Edvard I Moser,
... nature of such communications are still unknown. Here, Edvard Moser and colleagues simultaneously record from hippocampus and entorhinal ...
Tópico(s): Sleep and Wakefulness Research
2014 - Nature Portfolio | Nature
... properties of the stimulus. When May-Britt and Edvard Moser entered the field, they focused on analyzing how ... PubMed Scopus (380) Google Scholar). May-Britt and Edvard Moser were students of Per Andersen, an early pioneer ... of the Center for Neural Computation in Trondheim. Edvard I. Moser is Director of the Kavli Institute for Systems Neuroscience in Trondheim.Edvard I. Moser. Image courtesy of Geir Mogen/NTNU.View Large ...
Tópico(s): Sleep and Wakefulness Research
2014 - Cell Press | Cell
György Buzsáki, Edvard I Moser,
In this review, György Buzsáki and Edvard Moser discuss the most recent evidence suggesting that the navigation and memory functions of the hippocampus and entorhinal cortex are supported by the ...
Tópico(s): Sleep and Wakefulness Research
2013 - Nature Portfolio | Nature Neuroscience
Halle R. Dimsdale-Zucker, Charan Ranganath,
... Professors John O'Keefe, May-Britt Moser, and Edvard Moser brings global recognition to one of the most ...
Tópico(s): Stress Responses and Cortisol
2015 - Wiley | Hippocampus
Michael E. Hasselmo, Chantal E. Stern,
... John O'Keefe and May-Britt Moser and Edvard Moser. These findings provided an essential foothold for understanding ...
Tópico(s): Neural dynamics and brain function
2015 - Wiley | Hippocampus
Nobel prizewinners May-Britt Moser and Edvard Moser have spent a career together near the Arctic Circle exploring how our brains know where we are.
Tópico(s): Mitochondrial Function and Pathology
2014 - Nature Portfolio | Nature
... other half jointly to May-Britt Moser and Edvard I. Moser "for their discoveries of cells that constitute a ... other half jointly to May-Britt Moser and Edvard I. Moser "for their discoveries of cells that constitute a ...
Tópico(s): Memory and Neural Mechanisms
2014 - Cell Press | Neuron
... findings from the laboratory of May-Britt and Edvard Moser (Tsao et al. in Nature 561, 57–62, ...
Tópico(s): Sleep and Wakefulness Research
2019 - Springer Science+Business Media | Learning & Behavior
Julija Krupic, Marius Bauža, Stephen Burton, Caswell Barry, John O’Keefe,
... papers in this issue of Nature — one from Edvard Moser and colleagues and the other from John O' ...
Tópico(s): Photoreceptor and optogenetics research
2015 - Nature Portfolio | Nature
Christian F. Doeller, Caswell Barry, Neil Burgess,
The discovery by Edvard Moser and colleagues that rats and mice possess an orientation map of their surroundings, produced and updated by a network ...
Tópico(s): Neural dynamics and brain function
2010 - Nature Portfolio | Nature
... Laureates in Physiology or Medicine, John O’Keefe, Edvard Moser, and May-Britt Moser, have worked to explain ...
Tópico(s): Spatial Cognition and Navigation
2015 - Taylor & Francis | Science & Technology Libraries
Soledad Gonzalo Cogno, Horst A. Obenhaus, Ane Lautrup, R. Irene Jacobsen, Claudia Clopath, Sebastian O. Andersson, Flavio Donato, May‐Britt Moser, Edvard I Moser,
Abstract The medial entorhinal cortex (MEC) hosts many of the brain’s circuit elements for spatial navigation and episodic memory, operations that require neural activity to be organized across long durations of experience 1 . Whereas location is known to be encoded by spatially tuned cell types in this brain region 2,3 , little is known about how the activity of entorhinal cells is tied together over time at behaviourally relevant time scales, in the second-to-minute regime. Here we show that MEC neuronal ...
Tópico(s): Neuroscience and Neuropharmacology Research
2023 - Nature Portfolio | Nature
Albert Tsao, S. Aryana Yousefzadeh, Warren H. Meck, May‐Britt Moser, Edvard I Moser,
Tópico(s): Memory and Neural Mechanisms
2022 - Nature Portfolio | Nature reviews. Neuroscience
Weijian Zong, Horst A. Obenhaus, Emilie Ranheim Skytøen, Hanna Eneqvist, Nienke L. de Jong, Ruben Vale, Marina Jorge, May‐Britt Moser, Edvard I Moser,
We developed a miniaturized two-photon microscope (MINI2P) for fast, high-resolution, multiplane calcium imaging of over 1,000 neurons at a time in freely moving mice. With a microscope weight below 3 g and a highly flexible connection cable, MINI2P allowed stable imaging with no impediment of behavior in a variety of assays compared to untethered, unimplanted animals. The improved cell yield was achieved through a optical system design featuring an enlarged field of view (FOV) and a microtunable ...
Tópico(s): Neural dynamics and brain function
2022 - Cell Press | Cell
Torgeir Waaga, Haggai Agmon, Valentin A. Normand, Anne Nagelhus, Richard J. Gardner, May‐Britt Moser, Edvard I Moser, Yoram Burak,
The representation of an animal's position in the medial entorhinal cortex (MEC) is distributed across several modules of grid cells, each characterized by a distinct spatial scale. The population activity within each module is tightly coordinated and preserved across environments and behavioral states. Little is known, however, about the coordination of activity patterns across modules. We analyzed the joint activity patterns of hundreds of grid cells simultaneously recorded in animals that were ...
Tópico(s): Neuroscience and Neuropharmacology Research
2022 - Cell Press | Neuron
Horst A. Obenhaus, Weijian Zong, R. Irene Jacobsen, Tobias Rose, Flavio Donato, Liangyi Chen, Heping Cheng, Tobias Bonhoeffer, May‐Britt Moser, Edvard I Moser,
The medial entorhinal cortex (MEC) creates a map of local space, based on the firing patterns of grid, head-direction (HD), border, and object-vector (OV) cells. How these cell types are organized anatomically is debated. In-depth analysis of this question requires collection of precise anatomical and activity data across large populations of neurons during unrestrained behavior, which neither electrophysiological nor previous imaging methods fully afford. Here, we examined the topographic arrangement ...
Tópico(s): Neuroendocrine regulation and behavior
2022 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Richard J. Gardner, Erik Hermansen, Marius Pachitariu, Yoram Burak, Nils A. Baas, Benjamin Dunn, May‐Britt Moser, Edvard I Moser,
The medial entorhinal cortex is part of a neural system for mapping the position of an individual within a physical environment
Tópico(s): Photoreceptor and optogenetics research
2022 - Nature Portfolio | Nature
Giuseppe Riva, Brenda K. Wiederhold,
... neuroscientific research, which led May-Britt Moser and Edvard I. Moser in 2014 to win the Nobel Prize for ...
Tópico(s): Digital Mental Health Interventions
2020 - Mary Ann Liebert, Inc. | Cyberpsychology Behavior and Social Networking
Miguel M. Carvalho, Nouk Tanke, Emilio Kropff, Menno P. Witter, May‐Britt Moser, Edvard I Moser,
Locomotion activates an array of sensory inputs that may help build the self-position map of the medial entorhinal cortex (MEC). In this map, speed-coding neurons are thought to dynamically update representations of the animal's position. A possible origin for the entorhinal speed signal is the mesencephalic locomotor region (MLR), which is critically involved in the activation of locomotor programs. Here, we describe, in rats, a circuit connecting the pedunculopontine tegmental nucleus (PPN) of the ...
Tópico(s): Neuroscience and Neuropharmacology Research
2020 - Cell Press | Cell Reports
Richard J. Gardner, Li Lu, Tanja Wernle, May‐Britt Moser, Edvard I Moser,
The network of grid cells in the medial entorhinal cortex (MEC) forms a fixed reference frame for mapping physical space. The mechanistic origin of the grid representation is unknown, but continuous attractor network models explain multiple fundamental features of grid cell activity. An untested prediction of these models is that the grid cell network should exhibit an activity correlation structure that transcends behavioral states. By recording from MEC cell ensembles during navigation and sleep, ...
Tópico(s): Sleep and Wakefulness Research
2019 - Nature Portfolio | Nature Neuroscience
Xenia Gofman, Gilad Tocker, Shahaf Weiss, Charlotte N. Boccara, Li Lu, May‐Britt Moser, Edvard I Moser, Genela Morris, Dori Derdikman,
Summary Navigation requires the integration of many sensory inputs to form a multi-modal cognitive map of the environment, which is believed to be implemented in the hippocampal region by spatially tuned cells [1–10]. These cells encode various aspects of the environment in a world-based (allocentric) reference frame. Although the cognitive map is represented in allocentric coordinates, the environment is sensed through diverse sensory organs, mostly situated in the animal's head, and therefore represented ...
Tópico(s): Axon Guidance and Neuronal Signaling
2019 - Elsevier BV | Current Biology
Martin Hägglund, Maria Mørreaunet, May‐Britt Moser, Edvard I Moser,
Grid cells fire in a triangular pattern that tessellates the environment [1]. The pattern displays a global distortion that is well described by a shearing transformation of an idealized grid [2]. However, in addition, distortions often differ across parts of the environment, suggesting that the grid interacts with the environment locally [2-5]. How this occurs is poorly understood. To further determine the nature of local distortions, we therefore analyzed the local spatial characteristics of the ...
Tópico(s): Circadian rhythm and melatonin
2019 - Elsevier BV | Current Biology
Øyvind Høydal, Emilie Ranheim Skytøen, Sebastian O. Andersson, May‐Britt Moser, Edvard I Moser,
The hippocampus and the medial entorhinal cortex are part of a brain system that maps self-location during navigation in the proximal environment1,2. In this system, correlations between neural firing and an animal’s position or orientation are so evident that cell types have been given simple descriptive names, such as place cells3, grid cells4, border cells5,6 and head-direction cells7. While the number of identified functional cell types is growing at a steady rate, insights remain limited by ...
Tópico(s): Axon Guidance and Neuronal Signaling
2019 - Nature Portfolio | Nature
Jing Ye, Menno P. Witter, May‐Britt Moser, Edvard I Moser,
The mammalian positioning system contains a variety of functionally specialized cells in the medial entorhinal cortex (MEC) and the hippocampus. In order for cells in these systems to dynamically update representations in a way that reflects ongoing movement in the environment, they must be able to read out the current speed of the animal. Speed is encoded by speed-responsive cells in both MEC and hippocampus, but the relationship between the two populations has not been determined. We show here ...
Tópico(s): Sleep and Wakefulness Research
2018 - National Academy of Sciences | Proceedings of the National Academy of Sciences
... to John O’Keefe, May-Britt Moser, and Edvard I. Moser). Notably, neuroscience studies on emotion with music reveal ...
Tópico(s): Emotion and Mood Recognition
2018 - Cell Press | Neuron
Albert Tsao, Jørgen Sugar, Li Lu, Cheng Wang, James Knierim, May‐Britt Moser, Edvard I Moser,
Tópico(s): Neuroscience and Neuropharmacology Research
2018 - Nature Portfolio | Nature
Tanja Wernle, Torgeir Waaga, Maria Mørreaunet, Alessandro Treves, May‐Britt Moser, Edvard I Moser,
Tópico(s): Photoreceptor and optogenetics research
2017 - Nature Portfolio | Nature Neuroscience
Flavio Donato, R. Irene Jacobsen, May‐Britt Moser, Edvard I Moser,
The lights go on in order Grid cells and place cells in the brain function as part of a circuit that helps us figure out where we are in our physical world. Donato et al. examined how that circuit develops in the brains of mice. Expression patterns of doublecortin and parvalbumin revealed that neurons in the circuit mature in the order in which information flows. Maturation of each piece of the circuit depends on excitatory neuronal activity from the preceding portion. Stellate cells, in contrast, ...
Tópico(s): Neurogenesis and neuroplasticity mechanisms
2017 - American Association for the Advancement of Science | Science