Teresa Kowalik‐Jankowska, Elżbieta Jankowska, Zbigniew Szewczuk, Franciszek Kasprzykowski,
The classical tachykinins, substance P, neurokinin A and neurokinin B are predominantly found in the nervous system where they act as neurotransmitters and neuromodulators. Significantly reduced levels of these peptides were observed in neurodegenerative diseases and it may be suggested that this reduction may also result from the copper(II)-catalyzed oxidation. The studies of the interaction of copper(II) with neurokinin A and the copper(II)-catalyzed oxidation were performed. Copper(II) complexes ...
Tópico(s): Free Radicals and Antioxidants
2010 - Elsevier BV | Journal of Inorganic Biochemistry
Teresa Kowalik‐Jankowska, Elżbieta Jankowska, Franciszek Kasprzykowski,
Stoichiometry, stability constants, and solution structures of copper(II) complexes of the (1−2,10−21)NPγ (D1−A2−K10−R−H12−K−T−D−S−F−V−G−L−M21−NH2) and Ac−(1−2,10−21)NPγ (Ac−D1−A2−K10−R−H12−K−T−D−S−F−V−G−L−M21−NH2) fragments of neuropeptide γ were determined in aqueous solution in the pH range 2.5−10.5. The potentiometric and spectroscopic data (UV−vis, CD, EPR) show that an N-terminal Asp residue stabilizes significantly the copper(II) complexes with 1N {NH2, β-COO−} and 2N {NH2, β-COO−, NIm} coordination ...
Tópico(s): Free Radicals and Antioxidants
2010 - American Chemical Society | Inorganic Chemistry
Ewelina Wesołowska, Agnieszka Jankowska, Elżbieta Trafalska, Paweł Kałużny, Mariusz Grzesiak, Jolanta Dominowska, Wojciech Hanke, Gemma Calamandrei, Kinga Polańska,
Background: Characterization of dietary patterns represents a valid and meaningful measure of overall diet quality and nutrient intake. The study aims at evaluating the sociodemographic, lifestyle, environmental, and pregnancy-related determinants of maternal dietary patterns during pregnancy. Methods: The analysis was conducted on a group of pregnant women from the Polish Mother and Child Cohort (REPRO_PL). During the second trimester of pregnancy, 1306 women filled in a modified version of the ...
Tópico(s): Obesity, Physical Activity, Diet
2019 - Multidisciplinary Digital Publishing Institute | International Journal of Environmental Research and Public Health
Jolanta Hybiak, Izabela Broniarek, Gerard Kiryczyński, Laura.D. Los, Jakub Rosik, Filip Machaj, Hubert Sławiński, Kornelia Jankowska, Elżbieta Urasińska,
Aspirin (acetylsalicylic acid), the oldest synthetic drug, was originally used as an anti-inflammatory medication. Being an irreversible inhibitor of COX (prostaglandin-endoperoxide synthase) enzymes that produce precursors for prostaglandins and thromboxanes, it has gradually found several other applications. Sometimes these applications are unrelated to its original purpose for example its use as an anticoagulant. Applications such as these have opened opportunities for new treatments. In this case, ...
Tópico(s): Eicosanoids and Hypertension Pharmacology
2019 - Elsevier BV | European Journal of Pharmacology
Maciej Karwowski, Aleksandra Zielińska, Dorota M. Jankowska, Elzbieta Strutyńska, Iwona Omelańczuk, Izabela Lebuda,
The coronavirus disease 2019 (COVID-19) pandemic is influencing our lives in an enormous and unprecedented way. Here, we explore COVID-19-lockdown's consequences for creative activity. To this end, we relied on two extensive diary studies. The first, held on March 2019 (pre-pandemic), involved 78 students who reported their emotions and creativity over 2 weeks (927 observations). The second, conducted on March 2020 (during the pandemic and lockdown), involved 235 students who reported on their emotions, ...
Tópico(s): Identity, Memory, and Therapy
2021 - Frontiers Media | Frontiers in Psychology
Anna Łabędź‐Masłowska, Barbara Lipert, Dominika Berdecka, Sylwia Kędracka‐Krok, Urszula Jankowska, Elżbieta Kamycka, Małgorzata Sekuła, Zbigniew Madeja, Buddhadeb Dawn, Jolanta Jura, Ewa Zuba‐Surma,
The current evidence suggests that beneficial effects of mesenchymal stem cells (MSCs) toward myocardial repair are largely due to paracrine actions of several factors. Although Monocyte chemoattractant protein-induced protein 1 (MCPIP1) is involved in the regulation of inflammatory response, apoptosis and angiogenesis, whether MCPIP1 plays any role in stem cell-induced cardiac repair has never been examined. By employing retroviral (RV)-transduced overexpression of MCPIP1, we investigated the impact ...
Tópico(s): Cardiac Fibrosis and Remodeling
2015 - Public Library of Science | PLoS ONE
Teresa Kowalik‐Jankowska, A. Rajewska, Elżbieta Jankowska, Zbigniew Grzonka,
Metal-catalyzed oxidation (MCO) of proteins is mainly a site-specific process in which one or a few amino acids at metal-binding sites on the protein are preferentially oxidized. The oxidation of proteins by MCO can lead to oxidation of amino acid residue side chains, cleavage of the peptide bonds and formation of covalent protein-protein cross-linked derivatives. In an attempt to elucidate the products of the copper(II)-catalyzed oxidation of the 29-56, M29-D30-56 and Ac-M29-D30-56 fragments of ...
Tópico(s): Biochemical effects in animals
2008 - Royal Society of Chemistry | Dalton Transactions
Teresa Kowalik‐Jankowska, A. Rajewska, Elżbieta Jankowska, Kornelia Wiśniewska, Zbigniew Grzonka,
Tópico(s): Advanced Glycation End Products research
2006 - Elsevier BV | Journal of Inorganic Biochemistry
Teresa Kowalik‐Jankowska, A. Rajewska, Elżbieta Jankowska, Zbigniew Grzonka,
Stability constants and ligand donor sets of the copper(II) complexes of the NH2-29-56(L1)(AA30GKTKEGVLYV40GSKTKEGVVH50GVATVA56-NH2), NH2-M29-D30-56(L2) and Ac-M29-D30-56(L3) fragments of alpha-synuclein were determined in aqueous solution for 1 : 1 metal-to-ligand molar ratio in the pH range 2.5-10.5. The tyrosine residue in the 39th position of the alpha-synuclein fragments does not take part in the coordination of the metal ion. The potentiometric and spectroscopic data (UV-Vis, CD, EPR) show that ...
Tópico(s): Electrochemical Analysis and Applications
2006 - Royal Society of Chemistry | Dalton Transactions
S. Kowalak, Aldona Jankowska, Elżbieta Baran,
Zincophosphate sodalites can be obtained by simple grinding of the substrate salts [ZnCl2, Zn(NO3)2, Na2HPO4, Na2CO3] in a mortar, provided that at least one of the applied salts contains crystallization water.
Tópico(s): Chemical Synthesis and Characterization
2001 - Royal Society of Chemistry | Chemical Communications
Marian Gorynia, Barbara Jankowska, Elżbieta Maślak,
Tópico(s): Polish socio-economic development
2000 - SGH Warsaw School of Economics | Gospodarka Narodowa
Ewa A. Jankowska, Elżbieta Kalicińska, Marcin Drozd, Beata Kurian, Waldemar Banasiak, Piotr Ponikowski,
We sought to determine and compare clinical profile and management of outpatients with heart failure with reduced ejection fraction (HFREF) treated by cardiologists and general practitioners (GPs) in Poland.All the 790 randomly selected cardiologists and GPs in the DATA-HELP registry, which included 5563 patients, filled out questionnaires about 10 consecutive outpatients with HFREF.Outpatients managed by GPs were older (69±10 vs 66±12 years), and the prevalence of men was less marked (58% vs 67%). ...
Tópico(s): Cardiac pacing and defibrillation studies
2014 - Elsevier BV | International Journal of Cardiology
E. Sandra Chocrón, Erin Munkácsy, Harper S. Kim, Przemysław Karpowicz, Nisi Jiang, Candice E. Van Skike, Nicholas DeRosa, Andy Banh, Juan Pablo Palavicini, Paweł Wityk, Leszek Kalinowski, Verónica Galván, Paweł A. Osmulski, Elżbieta Jankowska, Maria Gaczyńska, Andrew M. Pickering,
The proteasome has key roles in neuronal proteostasis, including the removal of misfolded and oxidized proteins, presynaptic protein turnover, and synaptic efficacy and plasticity. Proteasome dysfunction is a prominent feature of Alzheimer's disease (AD). We show that prevention of proteasome dysfunction by genetic manipulation delays mortality, cell death, and cognitive deficits in fly and cell culture AD models. We developed a transgenic mouse with neuronal-specific proteasome overexpression that, ...
Tópico(s): Genetics and Neurodevelopmental Disorders
2022 - American Association for the Advancement of Science | Science Advances
Arkadiusz Czerwonka, Marta J. Fiołka, Katarzyna Jędrzejewska, Elżbieta Jankowska, Adrian Zając, Wojciech Rzeski,
Earthworm coelomic fluid (CF) is known as a rich source of various bioactive compounds with promising anticancer features. However, it has been demonstrated that CF affects functionality of both, cancer and normal cells. This non-selective activity causes a major problem for medical application of CF. In this study, we present the anticancer activity of the active protein-carbohydrate fraction (AF) isolated from thermally treated CF of earthworm Dendrobaena veneta. The in vitro effect of the AF was ...
Tópico(s): Protein Hydrolysis and Bioactive Peptides
2020 - Elsevier BV | Biomedicine & Pharmacotherapy
Karolina Pierzynowska, Lidia Gaffke, Elżbieta Jankowska, Estera Rintz, Julia Witkowska, Ewa Wieczerzak, Magdalena Podlacha, Grzegorz Węgrzyn,
In this study, we have asked whether proteasome composition and function are affected in cells derived from patients suffering from all types of mucopolysaccharidosis (MPS), an inherited metabolic disease caused by accumulation of undegraded glycosaminoglycans (GAGs). Moreover, we have tested if genistein, a small molecule proposed previously as a potential therapeutic agent in MPS, can modulate proteasomes, which might shed a new light on the molecular mechanisms of action of this isoflavone as a ...
Tópico(s): T-cell and Retrovirus Studies
2020 - Frontiers Media | Frontiers in Cell and Developmental Biology
Paweł A. Osmulski, Przemysław Karpowicz, Elżbieta Jankowska, Jonathan Bohmann, Andrew M. Pickering, Maria Gaczyńska,
The proteasome is a pivotal element of controlled proteolysis, responsible for the catabolic arm of proteostasis. By inducing apoptosis, small molecule inhibitors of proteasome peptidolytic activities are successfully utilized in treatment of blood cancers. However, the clinical potential of proteasome activation remains relatively unexplored. In this work, we introduce short TAT peptides derived from HIV-1 Tat protein and modified with synthetic turn-stabilizing residues as proteasome agonists. ...
Tópico(s): Cancer-related Molecular Pathways
2020 - Multidisciplinary Digital Publishing Institute | Molecules
Renata Grzela, Karolina Nasilowska, Maciej Łukaszewicz, Michał Tyras, Janusz Stȩpiński, Marzena Jankowska‐Anyszka, Elżbieta Bojarska, Edward Darżynkiewicz,
Human Nudt16 (hNudt16) is a member of the Nudix family of hydrolases, comprising enzymes catabolizing various substrates including canonical (d)NTPs, oxidized (d)NTPs, nonnucleoside polyphosphates, and capped mRNAs. Decapping activity of the Xenopus laevis (X29) Nudt16 homolog was observed in the nucleolus, with a high specificity toward U8 snoRNA. Subsequent studies have reported cytoplasmic localization of mammalian Nudt16 with cap hydrolysis activity initiating RNA turnover, similar to Dcp2. The ...
Tópico(s): RNA regulation and disease
2018 - Cold Spring Harbor Laboratory Press | RNA
Małgorzata Giżyńska, Julia Witkowska, Przemysław Karpowicz, R. Rostankowski, E. Sandra Chocrón, Andrew M. Pickering, Paweł A. Osmulski, Maria Gaczyńska, Elżbieta Jankowska,
Proline- and arginine-rich peptide PR11 is an allosteric inhibitor of 20S proteasome. We modified its sequence inter alia by introducing HbYX, RYX, or RHbX C-terminal extensions (Hb, hydrophobic moiety; R, arginine; Y, tyrosine; X, any residue). Consequently, we were able to improve inhibitory potency or to convert inhibitors into strong activators: the former with an aromatic penultimate Hb residue and the latter with the HbYX motif. The PR peptide activator stimulated 20S proteasome in vitro to ...
Tópico(s): Glycosylation and Glycoproteins Research
2018 - American Chemical Society | Journal of Medicinal Chemistry
Pietro Boccaletto, Marcin Magnus, Catarina Almeida, Adriana Żyła, Astha Astha, Radosław Pluta, Błażej Bagiński, Elżbieta Jankowska, Stanisław Dunin-Horkawicz, Tomasz Wirecki, M. Boniecki, Filip Stefaniak, Janusz M. Bujnicki,
RNArchitecture is a database that provides a comprehensive description of relationships between known families of structured non-coding RNAs, with a focus on structural similarities. The classification is hierarchical and similar to the system used in the SCOP and CATH databases of protein structures. Its central level is Family, which builds on the Rfam catalog and gathers closely related RNAs. Consensus structures of Families are described with a reduced secondary structure representation. Evolutionarily ...
Tópico(s): RNA Research and Splicing
2017 - Oxford University Press | Nucleic Acids Research
Julia Witkowska, Małgorzata Giżyńska, P. Grudnik, Przemysław Golik, Przemysław Karpowicz, Artur Giełdoń, Grzegorz Dubin, Elżbieta Jankowska,
Abstract Proteasomes are responsible for protein turnover in eukaryotic cells, degrading short-lived species but also removing improperly folded or oxidatively damaged ones. Dysfunction of a proteasome results in gradual accumulation of misfolded/damaged proteins, leading to their aggregation. It has been postulated that proteasome activators may facilitate removal of such aggregation-prone proteins and thus prevent development of neurodegenerative disorders. However, the discovery of pharmacologically ...
Tópico(s): Glycosylation and Glycoproteins Research
2017 - Nature Portfolio | Scientific Reports
Wayne Dawson, Maciej Maciejczyk, Elżbieta Jankowska, Janusz M. Bujnicki,
Functional RNA molecules depend on three-dimensional (3D) structures to carry out their tasks within the cell. Understanding how these molecules interact to carry out their biological roles requires a detailed knowledge of RNA 3D structure and dynamics as well as thermodynamics, which strongly governs the folding of RNA and RNA-RNA interactions as well as a host of other interactions within the cellular environment. Experimental determination of these properties is difficult, and various computational ...
Tópico(s): RNA Research and Splicing
2016 - Elsevier BV | Methods
... two excellent studies, performed by the group of Elzbieta Jankowska in rats (Bolzoni et al. 2013a) and cats ( ...
Tópico(s): Muscle activation and electromyography studies
2013 - Wiley | The Journal of Physiology
Aneta Szymańska, Elżbieta Jankowska, Marta Orlikowska, Izabela Behrendt, Paulina Czaplewska, Sylwia Rodziewicz‐Motowidło,
Human cystatin C (hCC) is a small but very intriguing protein. Produced by all nucleated cells is found in almost all tissues and body fluids where, at physiological conditions, plays a role of a very potent inhibitor of cysteine proteases. Biologically active hCC is a monomeric protein but during cellular trafficking it forms dimers, transiently losing its inhibitory activity. In vitro, dimerization of cystatin C was observed for the mature protein during crystallization trials, revealing that the ...
Tópico(s): Biomedical Research and Pathophysiology
2012 - Frontiers Media | Frontiers in Molecular Neuroscience
Elżbieta Jankowska, Julia Stoj, Przemysław Karpowicz, Paweł A. Osmulski, Maria Gaczyńska,
The giant proteolytic factory called the proteasome came a long way from a biochemical curio to a major regulator of cellular physiology and a renowned drug target within the ubiquitin proteasome pathway (UPP). Thanks to availability of highly specific inhibitors of the proteasome, in less than twenty years it was possible to identify major transcription factors, cyclins, and products of oncogenes as crucial substrates for the UPP. Nine years passed since the FDA speedily approved bortezomib, the ...
Tópico(s): Glycosylation and Glycoproteins Research
2012 - Bentham Science Publishers | Current Pharmaceutical Design
Marta Pietruszka, Elżbieta Jankowska, Teresa Kowalik‐Jankowska, Zbigniew Szewczuk, Maria Smużyńska,
The stability constants, stoichiometry, and solution structures of copper(II) complexes of neuropeptide gamma (NPG) (D1-A-G-H4-G-Q-I-S-H9-K-R-H12-K-T-D-S–F-V-G-L-M21-NH2) and acethyl–neuropeptide gamma (Ac–D1-A-G-H4-G-Q-I-S-H9-K-R-H12-K-T-D-S-F-V-G-L-M21-NH2) were determined in aqueous solution. For both peptides the additional deprotonations were observed; therefore, the potentiometric data calculations for NPG were only made in 2.5–7.4 pH range. For Ac–NPG one additional deprotonation was observed, ...
Tópico(s): Electron Spin Resonance Studies
2011 - American Chemical Society | Inorganic Chemistry
Marta Orlikowska, Elżbieta Jankowska, R. Kolodziejczyk, Mariusz Jaskólski, Aneta Szymańska,
Tópico(s): Folate and B Vitamins Research
2010 - Elsevier BV | Journal of Structural Biology
Elżbieta Jankowska, Maria Gaczyńska, Paweł A. Osmulski, Emilia Sikorska, R. Rostankowski, Srividya Madabhushi, Monika Tokmina‐Lukaszewska, Franciszek Kasprzykowski,
Proteasome, consisting of a tube-shaped proteolytic core particle and attached to it regulatory modules, is a multifunctional enzymatic complex essential for the ubiquitin-proteasome metabolic pathway. Due to its immense involvement in regulation of cellular physiology, the proteasome is an acknowledged anticancer drug target and potential target to treat inflammatory or degenerative diseases. So far, competitive inhibitors of the core particle gain most consideration as drugs. We postulate that ...
Tópico(s): HIV Research and Treatment
2010 - Wiley | Biopolymers
Michael Reich, Ewa Wieczerzak, Elżbieta Jankowska, David Palesch, Bernhard O. Boehm, Timo Burster,
Cathepsins of the cysteine, aspartyl, and serine classes are involved in antigen processing in the class II major histocompatibility complex (MHC) loading compartment. Investigation of these proteases in living cells is difficult to perform due to the lack of highly specific cell-permeable inhibitors. Recently, a highly selective cathepsin B (CatB) inhibitor, Z-Arg-Leu-Arg-alpha-aza-glycyl-Ile-Val-OMe (ZRLR), was described. We found that ZRLR is cell-permeable and specifically inhibits CatB, in contrast ...
Tópico(s): Immune Response and Inflammation
2009 - Elsevier BV | Immunology Letters
Daniela Valensin, Łukasz Szyrwiel, Francesca Camponeschi, Magdalena Rowińska‐Żyrek, Elena Molteni, Elżbieta Jankowska, Aneta Szymańska, Elena Gaggelli, Gianni Valensin, Henryk Kozłowski,
The homeostasis of metal ions, especially copper and zinc, is a major factor that may influence the prion diseases and the biological function of prion protein (PrP). The His-rich regions are basic sites for metal binding and antioxidant activity of the PrP structures. Animal prion-like proteins contain also His-rich domains, and their coordination chemistry may provide better insight into the chemistry and biology of PrP structures and related diseases. Herein, we report an equilibrium study on ...
Tópico(s): Crystallography and molecular interactions
2009 - American Chemical Society | Inorganic Chemistry
Łukasz Szyrwiel, Elżbieta Jankowska, Anna Janicka-Kłos, Zbigniew Szewczuk, Daniela Valensin, Henryk Kozłowski,
Multi-histidine peptide fragments of zebra-fish prion protein are effective ligands for Zn(II) ions. Moreover the formation of a dinuclear complex species with a longer peptide can suggest the existence of the cooperative effect in the metal ion binding.
Tópico(s): Drug Transport and Resistance Mechanisms
2008 - Royal Society of Chemistry | Dalton Transactions