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Jeremy Rundall, Alan Owens, J. J. R. Trethowan, Charles Raw, Richard Buckle, James Margach, Elizabeth Nicholas, Nicholas Carroll Diplomatic Correspondent, Harold Hobson, Pearce Wright, J Fowler, Antony Terry, Roger Nuttall, Vincent Rendel, John Allan, A C Sykes, Cal McCrystal, Michael Shanks Economic Correspondent, Elizabeth Good, Charles Ede, Henry Brandon, (Mrs) Winnifred B Hillier, John Russell, Jack Cox, T R Summers Director, J Hywel Jones Headmaster, (Rev) G Dennis Spiller, Geoffrey Nicholson, Max Marquis, Hugh Wynn, Barbara Bray, Derek Jewell, Vivian Jenkins, Evelyn Waugh, H du P Richardson (Comdr Rn), Brian Jackson, Edmund Stevens, Tom Margerison, Peter Willett, Sir Philip Magnus, J H C Leach, Robin Marlar, L Sefton Managing Director, David Benson, Cyril Connolly, Graham Norton, Kathleen Halton, Anthony Vice, Michael Howard, Cyril Musgrave Chairman, C. L. Sulzberger, James Pope-Hennessy, Evelyn Irons, C Bradlaugh Bonner, Peter Wilsher, Susan Noel, Elisabeth Woolley, Barbara Goalen, Michael Limb, Lord Wakefield, Roger Mortimer, Priscilla Chapman, Ernestine Carter, Desmond Shawe-Taylor, Stephen Coulter, Meriel McCooey, Peter Mansfield, Alan Wykes, B. P. Barnes, Charles Fox, Ronald Legge, Lanning Roper, Dilys Powell, Hugh Johnson, C J L Hutton Squire, Brigid Keenan, A V Lyle (Comdr Rn), Maxwell Boyd Motoring Correspondent, David Wiggins, Robert Carrier, Felix Aprahamian, M J Harding, Rev M C D'arcy, Benjamin Pogrund, H J Andrews, Elena Korenevskaya, Michael Ratcliffe, Ian Coulter Industrial Correspondent, Henry Longhurst, Lewis Chester, Godfrey Smith, James Margach Political Correspondent, Christopher Ricks, Michael Moynihan, Brian Glanville, John Connell, Keith Richardson, Laura Tatham, Peter Dunn, Michael Green, John Haworth, C. H. O'd. Alexander, Maurice Wiggin, Phillip Knightley, Anthony Cowdy, Kenneth Konstam, John Amis, R H Merrett, Nicholas Tomalin,

... Personal Dimplex English is the craze in Russia Elena Korenevskaya, a Moscow housewife and journalist, says Radical ... Choice of suspense Peter Wilsher on radio serials Toledo Cigars In View Brighter birdwatching Richard Buckle welcomes ...

1964 - Gale Group | Sunday Times HA GDA

Artigo Revisado por pares

Jorge Iriarte, Manuel Murie-Fernández, Estefanía Toledo, Elena Urrestarazu, Manuel Alegre, C. Viteri, Javier Salvador, Peter Baptista, Belen Alcaide, Julio Artieda,

Periodic limb movements (PLM) and obstructive sleep apnea syndrome (OSAS) are two frequent sleep disorders which often occur in the same patient. The goal of this study was to know the influence of the presence of PLM in the sleep architecture in patients with and without OSAS. Two hundred twenty consecutive patients (69 women and 151 men) participated in this transversal study. They were patients with clinical suspicion of dysomnia, including snoring, OSAS, and PLM. All of them underwent a full polysomnography ...

Tópico(s): Sleep and related disorders

2009 - Lippincott Williams & Wilkins | Journal of Clinical Neurophysiology

Artigo Revisado por pares

Miguel Ángel Martínez‐González, Martín García–López, Maira Bes‐Rastrollo, Estefanía Toledo, Elena H. Martínez‐Lapiscina, Miguel Delgado‐Rodríguez, Zenaida Vázquez‐Ruiz, Silvia Benito, Juan J. Beunza,

Background and aim The Mediterranean diet is considered a model for healthy eating. However, prospective evidence in Mediterranean countries evaluating the relationship between this dietary pattern and non-fatal cardiovascular events is scarce. The aim of the present study was to evaluate the association between the adherence to the Mediterranean diet and the incidence of fatal and non-fatal cardiovascular events among initially healthy middle-aged adults from the Mediterranean area. Methods and ...

Tópico(s): Obesity, Physical Activity, Diet

2010 - Elsevier BV | Nutrition Metabolism and Cardiovascular Diseases

Artigo Acesso aberto Revisado por pares

Rodrigo A. Toledo, Elena Garralda, Maria Mitsi, Tirso Pons, Jorge Monsech, Estela Vega, Álvaro Otero, María I. Albarrán, Natalia Baños, Yolanda Durán, Victoria Bonilla, Francesca Sarno, Marta Camacho‐Artacho, Tania Sánchez‐Pérez, Sofía Perea, Rafael Álvarez, Alba De Martino, Daniel Lietha, Carmen Blanco‐Aparicio, Antonio Cubillo, Orlando Domı́nguez, Jorge L. Martı́nez-Torrecuadrada, Manuel Hidalgo,

Purpose: Despite the wide use of antiangiogenic drugs in the clinical setting, predictive biomarkers of response to these drugs are still unknown.Experimental Design: We applied whole-exome sequencing of matched germline and basal plasma cell-free DNA samples (WES-cfDNA) on a RAS/BRAF/PIK3CA wild-type metastatic colorectal cancer patient with primary resistance to standard treatment regimens, including inhibitors to the VEGF:VEGFR2 pathway. We performed extensive functional experiments, including ...

Tópico(s): Genetic factors in colorectal cancer

2018 - American Association for Cancer Research | Clinical Cancer Research

Artigo Revisado por pares

Laura Abraira, Estevo Santamarina, Sonia Cazorla, Alejandro Bustamante, Manuel Quintana, Manuel Toledo, Elena Fonseca, Laia Grau‐López, Marta Jiménez, Jordi Ciurans, Juan Luís Becerra, Mònica Millán, María Hernández‐Pérez, Pere Cardona, Mikel Terceño, Josep Zaragoza, David Cánovas, Teresa Gasull, Xavier Ustrell, Marta Rubiera, Mar Castellanos, Joan Montaner, José Álvarez‐Sabín,

Abstract Objective Blood biomarkers have not been widely investigated in poststroke epilepsy. In this study, we aimed to describe clinical factors and biomarkers present during acute stroke and analyze their association with the development of epilepsy at long term. Methods A panel of 14 blood biomarkers was evaluated in patients with ischemic and hemorrhagic stroke. Biomarkers were normalized and standardized using Z ‐scores. Stroke and epilepsy‐related variables were also assessed: stroke severity, ...

Tópico(s): S100 Proteins and Annexins

2020 - Wiley | Epilepsia

Revisão Acesso aberto Revisado por pares

Vicente Villanueva, Mar Carreño, António Gil‐Nagel, Pedro Jesús Serrano Castro, José M. Serratosa, Manuel Toledo, Elena Alvárez‐Barón, Alicia Gil, Silvia Subías-Labazuy,

Epilepsy is a serious neurological disease, ranking high in the top causes of disability. Approximately 40% of patients with epilepsy are pharmacoresistant after their seizures failed at least two antiseizure medications (ASMs). Adult patients experiencing focal-onset seizures (FOS) account for approximately 60% of all patients with epilepsy and they are more likely to become drug-resistant epilepsy (DRE) than those with generalized onset. Drug-resistant epilepsy is associated with mortality, morbidity, ...

Tópico(s): Bacterial Infections and Vaccines

2021 - Elsevier BV | Epilepsy & Behavior

Artigo Acesso aberto Revisado por pares

Ángel Acevedo-Duque, Romel Ramón González-Díaz, Alejandro Vega-Muñoz, Mirtha Mercedes Fernández Mantilla, Luiz Vicente Ovalles Toledo, Elena Cachicatari Vargas,

One of the particularities of companies with a social purpose is that, through their business model of B companies, they have incorporated into their processes the necessary mechanisms to obtain, simultaneously, the profits to ensure the existence of the organization in the market. At the same time, social value is generated, which is necessary to address the problems of the social crisis caused by COVID-19 and the environmental problems affecting the community. The current global health and economic ...

Tópico(s): Educational and Organizational Development

2021 - Multidisciplinary Digital Publishing Institute | Sustainability

Artigo Acesso aberto Revisado por pares

Roberta Haddad-Tóvolli, Sara Ramírez, Emma Muñoz‐Moreno, Maria Milà‐Guasch, Lluís Miquel-Rio, Macarena Pozo, Íñigo Chivite, Jordi Altirriba, Arnaud Obri, Alícia G. Gómez-Valadés, Míriam Toledo, Elena Eyre, Analı́a Bortolozzi, Emmanuel Valjent, Guadalupe Sòria, Marc Claret,

Preparation for motherhood requires a myriad of physiological and behavioural adjustments throughout gestation to provide an adequate environment for proper embryonic development1. Cravings for highly palatable foods are highly prevalent during pregnancy2 and contribute to the maintenance and development of gestational overweight or obesity3. However, the neurobiology underlying the distinct ingestive behaviours that result from craving specific foods remain unknown. Here we show that mice, similarly ...

Tópico(s): Eating Disorders and Behaviors

2022 - Nature Portfolio | Nature Metabolism

Artigo Acesso aberto Revisado por pares

María E. Gatica‐Ortega, María A. Pastor‐Nieto, Cristina Schöendorff‐Ortega, Manuela Mollejo, Ana M. Giménez‐Arnau,

... 5834 Department of Dermatology, Toledo Hospital Complex, 45071 Toledo, Spain Correspondence: María Elena Gatica-Ortega, Dermatology Department, Virgen del Valle Hospital, ... 5834 Department of Dermatology, Toledo Hospital Complex, 45071 Toledo, Spain Correspondence: María Elena Gatica-Ortega, Dermatology Department, Virgen del Valle Hospital, Toledo Hospital Complex, Carretera de Cobisa s/n, PC: ...

Tópico(s): Dermatology and Skin Diseases

2018 - Wiley | Contact Dermatitis

Artigo Acesso aberto

Jaime Gállego Pérez‐Larraya, Jon B. Toledo, Elena Urrestarazu, J. Iriarte,

Sleep disorders are frequent processes, both as a symptom associated with other diseases and as independent disorders. However, only in the last 4 decades has Sleep medicine gained its position among the medical specialties. In fact, it was only in these years that significant advances were obtained in the study of the etiology and treatment of these disorders. Similarly, the different classifications have been evolving over the years. First, they were based upon the clinical symptom; later on, ...

Tópico(s): Obstructive Sleep Apnea Research

2007 - Gobierno de Navarra | Anales del Sistema Sanitario de Navarra

Artigo Revisado por pares

M. G. de Bravo, Roberto J. de Antueno, Jonathan Toledo, María Elena De Tomás, Osvaldo Mercuri, C.J. Quintans,

Abstract The effects of the n−3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), on the growth of a human lung mucoepidermoid carcinoma (HLMC) in athymic mice were studied. The mice were divided into three groups which were given either a control chow diet (C), a chow diet supplemented with EPA/DHA (P) (25 or 50 mg of free n−3 fatty acids/g of pellet/day), or chow diet supplemented with palmitic acid (S) (isocaloric with P). Two independent experimental schedules were followed: i) ...

Tópico(s): Lipid metabolism and biosynthesis

1991 - Wiley | Lipids

Artigo Acesso aberto Revisado por pares

Rosaura Díaz, Luis I. García, Jose Locia, Milagros Silva Morales, Sara Rodríguez-Mora, César Antonio Pérez-Estudillo, Gonzálo Emiliano Aranda-Abreu, Jorge Manzo, Rebeca Toledo, Marı́a Elena Hernández,

It is known that hormones influence significantly the prostate tissue. However, we reported that mating induces an increase in androgen receptors, revealing a neural influence on the gland. These data suggested that somatic afferents (scrotal and genitofemoral nerves) and autonomic efferents (pelvic and hypogastric nerves) could regulate the structure of the prostate. Here we assessed the role of these nerves in maintaining the histology of the gland. Hence, afferent or efferent nerves of male rats ...

Tópico(s): Prostate Cancer Diagnosis and Treatment

2010 - Brazilian Academy of Sciences | Anais da Academia Brasileira de Ciências

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

Marcelo Custódio Rubira, Fernanda Marciano Consolim‐Colombo, Eneida Rejane Rabelo, Juan Carlos Yugar‐Toledo, Dulce Elena Casarini, Silmara Regina Coimbra, Luís Martins, Heitor Moreno, E M Krieger, Maria Cláudia Irigoyen,

Veins and arteries have active endothelium, producing vasoactive substances like nitric oxide. The aim of this study was to evaluate whether hypertensive patients exhibit venous endothelial dysfunction and to determine the relationship between endothelial‐dependent and endothelial‐independent vasodilation responses in venous and arterial systems. Sixteen unmedicated patients with stage I and II hypertension and without other risk factors and 15 matched normotensive volunteers had venous and arterial ...

Tópico(s): Heart Rate Variability and Autonomic Control

2007 - Wiley | Journal of Clinical Hypertension

Artigo Revisado por pares

Dolores Vázquez-Sanromán, Carles Sanchis‐Segura, Rebeca Toledo, Marı́a Elena Hernández, Jorge Manzo, Marta Miquel,

Environmental enrichment (EE) has been proposed as a factor that improves neuronal connectivity and brain plasticity. The induction of molecular mechanisms that takes place in the cortex, nucleus accumbens and hippocampus resulting from exposure to EE has been attributed partly to the role of neurotrophins as brain-derived neurotrophic factor (BDNF). Recent data directly implicate this neurotrophin in the modulation of plasticity changes in the cerebellum produced by living under environmental enrichment. ...

Tópico(s): RNA regulation and disease

2013 - Elsevier BV | Behavioural Brain Research

Artigo Acesso aberto Revisado por pares

Miguel Perez‐Pouchoulen, Marta Miquel, Paul Saft, Brenda Brug, Rebeca Toledo, Marı́a Elena Hernández, Jorge Manzo,

Abstract Valproic acid (VPA) is an anti‐epileptic drug with teratogenicity activity that has been related to autism. In rodents, exposure to VPA in utero leads to brain abnormalities similar than those reported in the autistic brain. Particularly, VPA reduces the number of Purkinje neurons in the rat cerebellum parallel to cerebellar abnormalities found in autism. Thus, we injected pregnant females on embryonic day 12 either with VPA (600 mg/kg, i.p.) or 0.9% saline solution and obtained the cerebellum ...

Tópico(s): Autism Spectrum Disorder Research

2016 - Wiley | International Journal of Developmental Neuroscience

Artigo Revisado por pares

Erika Gómez‐Pineda, Cuauhtémoc Sáenz‐Romero, Juan Manuel Ortega‐Rodríguez, Arnulfo Blanco‐García, Xavier Madrigal‐Sánchez, Roberto Lindig‐Cisneros, Leonel López-Toledo, Martha Elena Pedraza‐Santos, Gerald E. Rehfeldt,

Abstract The high biodiversity of the Mexican montane forests is concentrated on the Trans‐Mexican Volcanic Belt, where several Protected Natural Areas exist. Our study examines the projected changes in suitable climatic habitat for five conifer species that dominate these forests. The species are distributed sequentially in overlapping altitudinal bands: Pinus hartwegii at the upper timberline, followed by Abies religiosa , the overwintering host of the Monarch butterfly at the Monarch Butterfly ...

Tópico(s): Tree-ring climate responses

2019 - Wiley | Ecological Applications

Artigo Acesso aberto Revisado por pares

Luís Alfonso Ureña López, Xavier Rosselló, Dora Romaguera, Ángel M. Alonso‐Gómez, Estefanía Toledo, Elena Fortuny, Marta Noris, Caterina Mas-Lladó, Miquel Fiol, Raúl Ramallal, Lucas Tojal‐Sierra, Álvaro Alonso, Carlos Fernández-Palomeque,

The metabolic syndrome (MetS) is associated with increased cardiovascular morbidity and mortality. Characterization of cardiac structural and functional abnormalities due to the MetS can help recognize individuals who would benefit the most from preventive interventions. Transthoracic echocardiography (TTE) provides an opportunity to identify those abnormalities in a reproducible and cost-efficient manner. In research settings, implementation of protocols for the acquisition and analysis of TTE images ...

Tópico(s): Cardiac Arrhythmias and Treatments

2022 - Frontiers Media | Frontiers in Cardiovascular Medicine

Revisão Acesso aberto Revisado por pares

Genaro A. Coria‐Ávila, Deissy Herrera‐Covarrubias, Luis I. García, Rebeca Toledo, Marı́a Elena Hernández, Pedro Paredes-Ramos, Aleph A. Corona‐Morales, Jorge Manzo,

Among the different species of mammals, the expression of maternal behavior varies considerably, although the end points of nurturance and protection are the same. Females may display passive or active responses of acceptance, recognition, rejection/fear, or motivation to care for the offspring. Each type of response may indicate different levels of neural activation. Different natural stimuli can trigger the expression of maternal and paternal behavior in both pregnant or virgin females and males, ...

Tópico(s): Evolutionary Psychology and Human Behavior

2022 - Multidisciplinary Digital Publishing Institute | Animals

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

Li Yao, Francesca Schiavi, Alberto Cascón, Yuejuan Qin, Lucía Inglada‐Pérez, Elizabeth E. King, Rodrigo A. Toledo, Tonino Ercolino, Elena Rapizzi, Christopher J. Ricketts, Luigi Mori, Mara Giacché, Antonella Mendola, Elisa Taschin, Francesca Boaretto, Paola Loli, Maurizio Iacobone, Gian Paolo Rossi, Bernadette Biondi, José Viana Lima-Junior, Cláudio E. Kater, Marie Bex, Miikka Vikkula, Ashley Grossman, Stephen B. Gruber, Marta Barontini, Alexandre Persu, Maurizio Castellano, S. P. A. Toledo, Eamonn R. Maher, Massimo Mannelli, Giuseppe Opocher, Mercedes Robledo, Patricia L. M. Dahia,

Context Pheochromocytomas and paragangliomas are genetically heterogeneous neural crest–derived neoplasms. We recently identified germline mutations of the novel transmembrane-encoding gene FP/TMEM127 in familial and sporadic pheochromocytomas consistent with a tumor suppressor effect. Objectives To examine the prevalence and spectrum of FP/TMEM127 mutations in pheochromocytomas and paragangliomas and to test the effect of mutations in vitro. Design, Setting, and Participants We sequenced the FP/TMEM127 ...

Tópico(s): Cancer, Hypoxia, and Metabolism

2010 - American Medical Association | JAMA

Artigo Revisado por pares

Tomasz Dymerski, Jacek Namieśnik, Kann Vearasilp, Patricia Arancibia‐Ávila, Fernando Toledo, Moshe Weisz, Elena Katrich, Shela Gorinstein,

The volatile fractions of Cape gooseberry and blueberry were determined by headspace solid-phase microextraction coupled with comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry (HS-SPME/GC×GC-TOFMS). The highest amount of alcohol (51.8%), ester (32.8%) and carboxylic acid (6.9%) was in blueberry in comparison with gooseberry and oppositely ketones (14.7%), aldehydes (9.9%) and terpenes (8%) were found in gooseberry. The bioactive compounds and antioxidant capacities ...

Tópico(s): Advanced Chemical Sensor Technologies

2014 - Elsevier BV | Talanta

Artigo Acesso aberto Revisado por pares

Carina Soledad González González, Pedro Toledo, Miguel Padrón, Elena Santos, Mariana Cairós,

This paper presents the design approach of TANGO:H (Tangible Goals: Health): a platform for the creation of physical and cognitive rehabilitation exercises. This platform is adaptable to the characteristics of the population it is intended: children hospitalized and in home care. Also, it is highly configurable and customizable, thanks to exercises editor: TANGO:H Designer. This feature allows health professionals and educators to create game-like exercises, adapted to the specific needs of end users ...

Tópico(s): Health Education and Validation

2013 - Muhammadiyah University of Jakarta | Jurnal Teknologi

Capítulo de livro

Carina Soledad González González, Pedro Toledo, Miguel Padrón, Elena Santos, Mariana Cairós,

This paper presents an interactive platform called TANGO:H (Tangible Goals: Health) for the creation of social active play with gestural interaction. This platform has been specially designed and adapted for its recreational, educational and rehabilitation use in children at hospital. The platform has a game editor called TANGO:H Designer, which allows the creation of physical and cognitive exercises in single and multiplayer, so that children can play sequentially or simultaneously both competitively ...

Tópico(s): Children's Physical and Motor Development

2013 - Springer Nature | Advances in intelligent systems and computing

Artigo Acesso aberto

Heather Adams, Elena Quintana Toledo,

Although scientific research articles have traditionally been taken as examples of an objective style of writing that aims to minimise researchers’ voices in their texts (Gilbert and Mulkay, 1984:42), authors inevitably adopt stances towards the information presented and the target audience when writing their papers. This article explores authorial stance as expressed by adverbial markers in the introduction and conclusion sections of legal research papers. Following Biber et al. (1999), and Conrad ...

Tópico(s): Writing and Handwriting Education

2013 - Technical University of Valencia | Revista de Lingüística y Lenguas Aplicadas

Artigo Acesso aberto

M. Elena Antonio-Toledo, Edgar N. Sánchez, Alma Y. Alanís, Julio A. Flórez, Marco Pérez‐Cisneros,

This paper presents a nonlinear control of a quadrotor unmanned aerial vehicle(UAV) for trajectory tracking. The dynamical model is obtained by the Euler- Lagrange methodology. In this paper, the proposed control strategy is based on the integral backstepping technique with sliding mode control (SMC) for altitude and lateral motion. In addition, an inner loop control is used to stabilize the vehicle orientation. The implementation is applied to the Qball-X4 prototype of Quanser Inc. which has OptiTrackTM ...

Tópico(s): Distributed Control Multi-Agent Systems

2018 - Elsevier BV | IFAC-PapersOnLine

Artigo Revisado por pares

Eduardo Quintero-Manríquez, Edgar N. Sánchez, M. Elena Antonio-Toledo, Flavio Muñoz,

This paper presents the synthesis of an induction motor neural controller and a regenerative braking controller for an electric vehicle architecture, based on two energy system, a Main Energy System (MES) and an Auxiliary Energy System (AES). Such controllers are based on system identification, trajectory tracking and state estimation. System identification uses a Recurrent High Order Neural Network (RHONN), trained with an Extended Kalman Filter (EKF). RHONN obtains an accurate motor model which is ...

Tópico(s): Sensorless Control of Electric Motors

2021 - Elsevier BV | Engineering Applications of Artificial Intelligence

Artigo Revisado por pares

Ricardo Ortiz-Pulido, Marta Miquel, Luis I. García, César Antonio Pérez-Estudillo, Gonzálo Emiliano Aranda-Abreu, Rebeca Toledo, Marı́a Elena Hernández, Jorge Manzo,

The cerebellum is an important contributor to the neural basis of sexual behavior, but the specific cerebellar regions underlying different aspects of reproduction are still unknown. Here, we used experimental lesions of Lobules VIa and VII of the vermis to investigate their specific role, both in locomotion stimulated by sexual cues and the execution of sexual behavior. Sexually experienced male rats and receptive females were used, and experimental males received an electrolytic lesion of either ...

Tópico(s): Sleep and Wakefulness Research

2011 - Elsevier BV | Physiology & Behavior

Artigo Acesso aberto Revisado por pares

Olivia Prior, Carlos Macarro, Vı́ctor Navarro, Camilo Monreal, Marta Ligero, Alonso García-Ruiz, Garazi Serna, S. Simonetti, Irene Braña, María Vieito, Manuel Escobar, Jaume Capdevila, Annette T. Byrne, Rodrigo Dienstmann, Rodrigo A. Toledo, Paolo Nucíforo, Elena Garralda, Francesco Grussu, Kinga Bernatowicz, Raquel Pérez-López,

Purpose To identify precise three-dimensional radiomics features in CT images that enable computation of stable and biologically meaningful habitats with machine learning for cancer heterogeneity assessment. Materials and Methods This retrospective study included 2436 liver or lung lesions from 605 CT scans (November 2010–December 2021) in 331 patients with cancer (mean age, 64.5 years ± 10.1 [SD]; 185 male patients). Three-dimensional radiomics were computed from original and perturbed (simulated retest) ...

Tópico(s): Advanced X-ray and CT Imaging

2024 - Radiological Society of North America | Radiology Artificial Intelligence