Ibrahim El‐Battrawy, Michael Behnes, Uzair Ansari, Dennis Hillenbrand, Dariush Haghi, Ursula Hoffmann, Theano Papavassiliu, Elif Elmas, Christian Fastner, Tobias Becher, Stefan Baumann, Christina Dösch, Felix Heggemann, Jürgen Kuschyk, Martin Borggrefe, İbrahim Akın,
Takotsubo cardiomyopathy (TTC) is a relevant differential diagnosis in patients presenting with signs of an acute coronary syndrome. Although recent literature has highlighted some salient features of this disorder, there has been little information elucidating the differences in clinical features, electrocardiographic findings, echocardiographic data and TTC-related complications associated with the different variants of TTC.Our institutional database constituted a collective of 114 patients diagnosed ...
Tópico(s): Cardiovascular Issues in Pregnancy
2016 - Oxford University Press | QJM
Ibrahim El‐Battrawy, Siegfried Lang, Uzair Ansari, Michael Behnes, Dennis Hillenbrand, Katja Schramm, Christian Fastner, Xiaobo Zhou, Verena Bill, Ursula Hoffmann, Theano Papavassiliu, Elif Elmas, Darius Haghi, Martin Borggrefe, İbrahim Akın,
Previous studies revealed that patients with Takotsubo cardiomyopathy (TTC) have a higher mortality rate than the general population. Supraventricular tachycardia is a well-known complication of TTC. This study was performed to determine the short- and long-term prognostic impact of atrial fibrillation associated with TTC patients. Our institutional database constituted a collective of 114 patients diagnosed with TTC from 2003 to 2015. The patients were divided into two groups according to the presence ( ...
Tópico(s): Cardiac Structural Anomalies and Repair
2016 - Oxford University Press | EP Europace
Verena Bill, Ibrahim El‐Battrawy, Michael Behnes, Stefan Baumann, Tobias Becher, Elif Elmas, Ursula Hoffmann, Darius Haghi, Christian Fastner, Jürgen Kuschyk, Theano Papavassiliu, Martin Borggrefe, İbrahim Akın,
Takotsubo Cardiomyopathy (TC) is an acute reversible cardiomyopathy characterized by transient left (LV) ventricular apical ballooning with the absence of significant coronary artery disease [ [1] Korlakunta H.L. Thambidorai S.K. Denney S.D. Khan I.A. Transient left ventricular apical ballooning: a novel heart syndrome. Int. J. Cardiol. 2005; 102: 351-353 Abstract Full Text Full Text PDF PubMed Scopus (31) Google Scholar ]. However, detailed knowledge regarding aetiology of TC remains indistinct. Assuming ...
Tópico(s): Cardiac Structural Anomalies and Repair
2016 - Elsevier BV | International Journal of Cardiology
Tobias Becher, Ibrahim El‐Battrawy, Stefan Baumann, Christian Fastner, Michael Behnes, Dirk Loßnitzer, Elif Elmas, Ursula Hoffmann, Theano Papavassiliu, Jürgen Kuschyk, Christina Dösch, Susanne Röger, Dennis Hillenbrand, Katja Schramm, Martin Borggrefe, İbrahim Akın,
Objective Takotsubo cardiomyopathy, also known as stress-induced cardiomyopathy (SCM) resembles a reversible cardiomyopathy that is characterized by localized wall motion abnormalities in the absence of stenotic coronary vascular disease. Patients typically present with apical ballooning of the left ventricle (LV), however the right ventricle (RV) is also affected in up to 50.0% of patients. Long-term prognosis of classical SCM resembles that of patients after ST elevation myocardial infarction. Data ...
Tópico(s): Cardiac Imaging and Diagnostics
2016 - Elsevier BV | International Journal of Cardiology
Şule Gökyıldız Sürücü, Sultan Alan, Elif Elmas, Ayşegül Bostancı, Emine Özer Küçük,
This study aims to describe the health‐promoting lifestyle behaviours of pregnant women. The study was carried out with pregnant women who applied to the polyclinics in different maternity and children hospitals located in Adana, Turkey, between 1 M arch and 30 M ay 2009. The data collection tools used in the study were (i) a questionnaire that was used to collect sociodemographic data from the participants and (ii) the Health Promoting Lifestyle Profile II ( HPLP II ). The results obtained from the study ...
Tópico(s): Health, psychology, and well-being
2013 - Wiley | International Journal of Nursing Practice
Boris Rudic, Christian Veltmann, Esther Kuntz, Michael Behnes, Elif Elmas, Torsten Konrad, Jürgen Kuschyk, Christel Weiß, Martin Borggrefe, Rainer Schimpf,
For years early repolarization (ER) has been considered as a benign electrocardiographic finding. However, recent reports show that ER is associated with a higher incidence of ventricular fibrillation (VF) and sudden cardiac death in patients without structural heart disease. Sporadic case studies have pointed out that ER might be related to an adverse outcome in patients with stable coronary artery disease.To evaluate the incidence of ER in patients with acute myocardial infarction complicated by ...
Tópico(s): Ion channel regulation and function
2012 - Elsevier BV | Heart Rhythm
Ksenija Stach, Xuan Duc Nguyen, Siegfried Lang, Elif Elmas, Christel Weiß, Martin Borggrefe, Joachim E. Fischer, Thorsten Kälsch,
In addition to their cholesterol lowering ability, statins have proven pleiotropic effects in the cardiovascular system. Chronic inflammation with interactions between platelets and endothelial cells leads to an upregulation of activity markers of atherosclerosis. The purpose of this study was to investigate the effects of simvastatin and atorvastatin on platelets and endothelial cells in an in vitro endothelial cell model.After a 24 h incubation period with either simvastatin or atorvastatin (1 ...
Tópico(s): Lipoproteins and Cardiovascular Health
2012 - Via Medica | Cardiology Journal
Tom Oberheiden, Xuan Duc Nguyen, Marc Fatar, Elif Elmas, Christian Blahak, Nicole Morper, Carl Erik Dempfle, Michael G. Hennerici, Martin Borggrefe, Thorsten Kälsch,
An upregulation of platelet CD40 ligand (CD40L) and CD62P has been described in atherosclerotic cardiovascular diseases and among patients with acute cerebral ischemia. Correlation between platelet and monocyte activation and the etiology of ischemic stroke were examined in 41 patients with acute ischemic stroke. Compared to 10 controls, all patients with stroke showed a significantly elevated platelet expression of CD40L ( P < .001) and had significantly higher amounts of platelet–monocyte aggregates ( ...
Tópico(s): Extracellular vesicles in disease
2011 - SAGE Publishing | Clinical and Applied Thrombosis/Hemostasis
Rainer Pirzer, Elif Elmas, Dariusch Haghi, Christiane Lippert, Stefan Kralev, Siegfried Lang, Martin Borggrefe, Thorsten Kälsch,
Tópico(s): Spinal Hematomas and Complications
2011 - Springer Science+Business Media | Heart and Vessels
Ksenija Stach, Anna‐Isabelle Kälsch, Xuan Duc Nguyen, Elif Elmas, Stefan Kralev, Siegfried Lang, Christel Weiß, Martin Borggrefe, Thorsten Kälsch,
Inflammatory conditions contribute to increased expression of various activity markers in platelets and endothelial cells, leading to atherosclerotic changes in the vascular wall. The objective of this study was to investigate possible protective effects of 1α,25-dihydroxyvitamin D3 in an endothelial cell model.After a 24-hour incubation with 1α,25-dihydroxyvitamin D3, human umbilical vein endothelial cells were stimulated with lipopolysaccharide (LPS) and incubated in direct contact with platelets. ...
Tópico(s): Blood Coagulation and Thrombosis Mechanisms
2011 - Karger Publishers | Cardiology
Stephan Haas, Ralf Müller, A. Allwin Fernandes, Kristina Dzeyk-Boycheva, Susanne Würl, Jens Hohmann, Sabrina Hemberger, Elif Elmas, Martina Brückmann, Peter Bugert, Jürgen Backhaus,
Cardiovascular disease is the leading cause of death in Western civilization. In this pilot study we evaluated a new method for the diagnosis of myocardial infarction and heart failure by determining the typical fingerprint in the infrared (IR) spectrum of 1 μL of a dried patient serum sample by Fourier transform IR spectroscopy. For classification, cluster analysis and artificial neural networks (ANN) were applied. In this study 567 subjects were enrolled, comprising 225 controls (Co) and 342 patients ...
Tópico(s): Cardiac electrophysiology and arrhythmias
2010 - SAGE Publishing | Applied Spectroscopy
Elif Elmas, Peter Bugert, Tatjana Popp, Siegfried Lang, Christel Weiß, Michael Behnes, Martin Borggrefe, Thorsten Kälsch,
The P-Selectin Gene Polymorphism Val168Met.Ventricular fibrillation (VF) in the setting of acute myocardial infarction (AMI) is the leading cause of sudden cardiac death (SCD). Family history of SCD is described as risk factor for primary VF during acute AMI. Genetic factors may be associated with primary VF. We examined polymorphisms in genes related to the activation and adhesion of blood platelets in patients with and without VF in the setting of AMI and among healthy controls.Two hundred and forty ...
Tópico(s): Coronary Interventions and Diagnostics
2010 - Wiley | Journal of Cardiovascular Electrophysiology
Michael Behnes, Martina Brueckmann, Parviz Ahmad‐Nejad, Siegfried Lang, Christian Wolpert, Elif Elmas, Thorsten Kaelsch, Joachim Gruettner, Christel Weiβ, Martin Borggrefe, Michael Neumaier,
Background The purpose of this study was to determine the diagnostic power of a newly available assay for amino-terminal pro-brain natriuretic peptide (NT-proBNP) to identify patients with acute heart failure. In addition, the influence of initial NT-proBNP measurements on economic consequences, diagnostic procedures and staff involvement was evaluated. Methods and results 401 patients presenting with acute dyspnea or peripheral edema in the emergency department were enrolled. NT-proBNP was measured ...
Tópico(s): Emergency and Acute Care Studies
2008 - Elsevier BV | International Journal of Cardiology
Carl-Erik Dempfle, Thorsten Kälsch, Elif Elmas, Nenad Suvajac, Thomas Lücke, Elke Münch, Martin Borggrefe,
Fibrinogen concentration influences mechanical and functional properties of the clot. The purpose of the present study was to identify threshold concentrations of fibrinogen resulting in relevant changes in whole blood clot elastic modulus and platelet contractile force, as well as plasma prothrombin time and activated partial thromboplastin time. We measured clot elastic modulus, platelet contractile force, and other hemostasis parameters in whole blood samples from 552 patients admitted to a surgical ...
Tópico(s): Trauma, Hemostasis, Coagulopathy, Resuscitation
2008 - Lippincott Williams & Wilkins | Blood Coagulation & Fibrinolysis
Thorsten Kälsch, Elif Elmas, Xuan Duc Nguyen, Nenad Suvajac, Harald Klüter, Martin Borggrefe, C.‐E. Dempfle,
Tópico(s): Atherosclerosis and Cardiovascular Diseases
2007 - Springer Nature | Basic Research in Cardiology
Elif Elmas, Martina Brueckmann, Siegfried Lang, Thorsten Kälsch, Dariush Haghi, Tim Sueselbeck, Carl Erik Dempfle, Martin Borggrefe,
We compared the diagnostic performance of N-terminal pro-brain natriuretic peptide (NT-proBNP) with a newly developed assay for the midregional part of pro-atrial natriuretic peptide (MR-proANP) concerning the detection of impaired left ventricular ejection function (LVEF) among patients with coronary artery disease (CAD).Plasma levels of MR-proANP and NT-proBNP were determined in 102 consecutive patients with a history of ST-elevation myocardial infarction. Plasma levels of both markers were measured ...
Tópico(s): Atrial Fibrillation Management and Outcomes
2007 - Elsevier BV | International Journal of Cardiology
Elif Elmas, Siegfried Lang, Carl Erik Dempfle, Thorsten Kälsch, D Hannak, Tim Sueselbeck, Christian Wolpert, Martin Borggrefe, Martina Brueckmann,
Atherosclerotic plaques prone to cause thrombotic complications and plaque rupture account for the majority of fatal myocardial infarctions (MI), which may be complicated by ventricular fibrillation (VF). Matrix-degrading metalloproteinases (MMPs) and their inhibitors (TIMPs) are expressed in atherosclerotic lesions and contribute to plaque vulnerability. Interleukin-8 (IL-8) is one of the predominant chemokines interacting with MMPs and TIMPs and the coagulation system. The aim of the present study ...
Tópico(s): Atrial Fibrillation Management and Outcomes
2007 - De Gruyter | Clinical Chemistry and Laboratory Medicine (CCLM)
Michael Behnes, Jana Papassotiriou, Thomas Walter, E Fiedler, Tamara Sauer, Siegfried Lang, Elif Elmas, Ursula Hoffmann, Martin Borggrefe, Martina Brueckmann,
Background : Midregional pro-adrenomedullin (MR-proADM) and endothelin-1 have been shown to predict mortality of patients with acute myocardial infarction. However, the prognostic value of both biomarkers in predicting long-term clinical events after acute myocardial infarction remains unclear. Methods : In a prospective study, 30 patients suffering from acute ST elevation myocardial infarction or non-ST elevation myocardial infarction were enrolled. Measurements of MR-proADM and CT-pro-endothelin-1 ( ...
Tópico(s): Nitric Oxide and Endothelin Effects
2007 - De Gruyter | Clinical Chemistry and Laboratory Medicine (CCLM)
Elif Elmas, Thorsten Kaelsch, Christian Wolpert, Tim Sueselbeck, Thomas Bertsch, Carl Erik Dempfle, Martin Borggrefe,
Abstract Background : In most cases, sudden cardiac death is triggered by ischemia‐related ventricular tachyarrhythmias and accounts for 50% of deaths from cardiovascular disease in developed countries. Chronic elevation of indicators of coagulation activation has been found in patients with coronary heart disease, but a role of coagulation activation as a potential risk factor for ventricular fibrillation (VF) during acute myocardial infarction (MI) has not been investigated. Methods : We enrolled 50 ...
Tópico(s): Atrial Fibrillation Management and Outcomes
2006 - Wiley | Clinical Cardiology
Elif Elmas, Thorsten Kälsch, Nenad Suvajac, H. Leweling, Michael Neumaier, Carl-Erik Dempfle, Martin Borggrefe,
High intake of saturated fat is a predictor of coronary heart disease mortality. The phenomenon of postprandial angina pectoris has been described many years ago. Although earlier studies have demonstrated postprandial activation of coagulation factors VII and XII, platelets and monocytes, conclusive evidence for intravascular fibrin formation after a fat-rich meal has not been reported yet. The present study included 33 healthy physicians (7 females, 26 males) with a mean age of 42 years (range 27– ...
Tópico(s): Lipoproteins and Cardiovascular Health
2006 - Elsevier BV | International Journal of Cardiology
Thorsten Kälsch, Elif Elmas, Xuan Duc Nguyen, Nadine Grebert, Christian Wolpert, Harald Klüter, Martin Borggrefe, Karl K. Haase, Carl Erik Dempfle,
Background: Indicators of coagulation and inflammation are elevated in patients with coronary heart disease. A role of coagulation activation in ventricular fibrillation during acute myocardial infarction has not been described. Methods and Results: Whole blood samples of 21 patients with a history of acute myocardial infarction complicated by ventricular fibrillation and whole blood samples of 18 patients without ventricular fibrillation were incubated with lipopolysaccharide (LPS). In both groups, ...
Tópico(s): Antiplatelet Therapy and Cardiovascular Diseases
2005 - Wiley | Journal of Cardiovascular Electrophysiology
Thorsten Kälsch, Xuan Duc Nguyen, Elif Elmas, Nadine Grebert, Tim Süselbeck, Harald Klüter, Martin Borggrefe, Carl Erik Dempfle,
Background Elevated markers of inflammation and coagulation are found in patients with coronary heart disease. A role of inflammatory stimulation on coagulation time and expression of CD40 ligand on platelets in acute coronary syndromes has not been described yet. Methods and results Whole blood samples of 9 patients with coronary heart disease and stable angina, 10 patients with unstable angina, 7 patients with acute myocardial infarction and 7 patients without coronary heart disease were incubated ...
Tópico(s): Atherosclerosis and Cardiovascular Diseases
2005 - Elsevier BV | International Journal of Cardiology
Ralf Kaiser, Katharina Grotemeyer, Thorsten Kälsch, Stefan Gräber, Heinrike Wilkens, Elif Elmas,
TSP-1 is a vasoconstrictive protein, which is released from both endothelium and cardiomyocytes during ischemia and promotes platelet aggregation and adhesion to subendothelial layers in atherosclerotic lesions. During myocardial ischemia and reperfusion, TSP-1 disturbs local microcirculation by disrupting both NO-signaling as well as VEGF-pathways by activation of CD47 and CD36. Furthermore, activation of TGF-ß might induce excessive fibrosis after infarction. It was assumed that TSP-1 is washed ...
Tópico(s): Antiplatelet Therapy and Cardiovascular Diseases
2013 - IOS Press | Clinical Hemorheology and Microcirculation
Elif Elmas, Tatjana Popp, Siegfried Lang, Carl Erik Dempfle, Thorsten Kälsch, Martin Borggrefe,
Aims Sudden cardiac death (SCD) is frequently caused by ventricular fibrillation (VF) occurring in the course of acute myocardial infarction (AMI). It has not been investigated yet, to what extent markers of coagulation activation and inflammation differ between patients with and without VF in the acute phase of AMI.
Tópico(s): Adipokines, Inflammation, and Metabolic Diseases
2009 - Elsevier BV | International Journal of Cardiology
Elif Elmas, Lena Hölzer, Siegfried Lang, Tatjana Popp, Thorsten Kälsch, Christian Wolpert, Martina Brueckmann, Martin Borggrefe,
Aims. Ventricular fibrillation (VF) in the setting of acute myocardial infarction (AMI) is the leading cause of sudden cardiac death. A potential role of intrinsic, subclinical inflammatory states in patients suffering from ischemia-related VF has not been investigated yet. The aim of the present study was (i) to examine serum levels of proinflammatory markers in VF survivors and (ii) to evaluate basal and lipopolysaccharide (LPS)-stimulated interleukin-8-mRNA (IL-8-mRNA) levels in patients with and without ...
Tópico(s): Signaling Pathways in Disease
2008 - Elsevier BV | Cytokine
TIM BOEHRINGER, Peter Bugert, Martin Borggrefe, Elif Elmas,
Mutations in the SCN5A gene encoding the Nav1.5 channel α-subunit are known to be risk factors of arrhythmia, including Brugada Syndrome and Long QT syndrome subtype 3. The present study focused on the role of SCN5A variants in the development of ventricular fibrillation (VF) during acute myocardial infarction (AMI). Since VF during AMI is the major cause of sudden death in the Western world, SCN5A mutations represent genetic risk factors for sudden death. By exon re-sequencing, the entire coding ...
Tópico(s): Receptor Mechanisms and Signaling
2014 - Spandidos Publishing | Molecular Medicine Reports
Tom Oberheiden, Christian Blahak, Xuan Duc Nguyen, Marc Fatar, Elif Elmas, Nicole Morper, Carl‐Erik Dempfle, Hansjörg Bäzner, Michael G. Hennerici, Martin Borggrefe, Thorsten Kälsch,
Platelets and monocytes play a pivotal role in the initiation and progression of large-vessel atherosclerosis. An up-regulation of various platelet and coagulation activation markers has been described in cardiovascular diseases and in patients with acute cerebral ischemia. In the present study the role of platelets and cellular coagulation activation in cerebral small-vessel disease (cSVD) was assessed. In 24 patients with cSVD but without established large-vessel disease, whole blood samples were ...
Tópico(s): Cell Adhesion Molecules Research
2010 - Lippincott Williams & Wilkins | Blood Coagulation & Fibrinolysis
Elif Elmas, Siegfried Lang, Carl Erik Dempfle, Thorsten Kälsch, Jana Papassotiriou, Nils G. Morgenthaler, Martin Borggrefe, Martina Brueckmann,
In ambulatory patients with coronary artery disease (CAD) we aimed to evaluate the diagnostic performance of mid-regional pro-adrenomedullin (MR-proADM) for the detection or exclusion of impaired left ventricular ejection fraction (LVEF).MR-proADM levels were measured in blood samples taken from 102 outpatients with CAD classified according to the New York Heart Association (NYHA) and Canadian Cardiovascular society (CCS) I-II. Increased levels of MR-proADM correlated with impaired LVEF (r=-0.21, p=0. ...
Tópico(s): Receptor Mechanisms and Signaling
2007 - Elsevier BV | International Journal of Cardiology
Thorsten Kälsch, Elif Elmas, Xuan Duc Nguyen, Stefan Kralev, H. Leweling, Harald Klüter, Carl‐Erik Dempfle, Martin Borggrefe,
In patients with chronic hypercholesterolemia, the CD40-CD40L dyad is upregulated, contributing to the initiation and progression of atherosclerosis. Our aim was to describe the role of postprandial lipemia and inflammatory stimulation on platelet and monocyte activation and CD40-ligand (CD40L) levels.Before and 2 h after consumption of a defined fatty meal, whole blood samples of 31 healthy subjects were incubated with endotoxin (LPS). CD40-ligand and CD62P expression on platelets, tissue-factor ...
Tópico(s): Immune Cell Function and Interaction
2007 - Elsevier BV | Thrombosis Research
Thorsten Kälsch, Elif Elmas, Xuan Duc Nguyen, Christian Wolpert, Harald Klüter, Martin Borggrefe, Karl K. Haase, Carl Erik Dempfle,
Acute myocardial infarction can be complicated by ventricular arrhythmias due to electrophysiological changes in the ischemic myocardium, but the exact predisposing factors causing ventricular fibrillation during myocardial infarction still remain unclear. A role of inflammatory stimulation on platelets as a potential risk factor for ventricular fibrillation during acute myocardial infarction has not been described yet.Whole blood samples of 21 patients with a history of acute myocardial infarction ( ...
Tópico(s): Adipokines, Inflammation, and Metabolic Diseases
2005 - Elsevier BV | International Journal of Cardiology