Produção Nacional
Revisado por pares
André Palmini, Antonio Gambardella, Frédérick Andermann, François Dubeau, Jaderson Costa da Costa, André Olivier, Donatella Tampieri, P. Gloor, Felipe Quesney, Eva Andermann, Eduardo Paglioli, Eliseu Paglioli‐Neto, Ligia Coutinho Andermann, Richard Leblanc, Hyoung‐Ihl Kim,
Abstract Cortical dysplastic lesions (CDyLs) are often associated with severe partial epilepsies. We describe the electrographic counterpart of this high degree of epileptogenicity, manifested by continuous or frequent rhythmic epileptogenic discharges recorded directly from CDyLs during intraoperative electrocorticography (ECoG). These ictal or continuous epileptogenic discharges (I/CEDs) assumed one of the following three patterns: (1) repetitive electrographic seizures, (2) repetitive bursting discharges, ...
Tópico(s): Neuroscience and Neuropharmacology Research
1995 - Wiley | Annals of Neurology
Produção Nacional
Revisado por pares
André Palmini, Antonio Gambardella, Frédérick Andermann, François Dubea, Jaderson Costa da Cos, André Olivi, Donatella Tampie, Yvon Robitaill, Eduardo Paglioli, Eliseu Paglioli Neto, Lígia Maria Barbosa Coutinho, Hyoung‐Ihl Kim,
Summary: Cortical dysplastic lesions (CDLs) are usually identified by magnetic resonance imaging (MRI). Clinical, electrographic and histologic findings suggest that focal CDLs (FCDLs) are highly epileptogenic, often involve the rolandic cortex, and can present variable degrees of histopathologic abnormalities. An ictal or “ictal‐like” bursting pattern of electrographic activity was recorded over dysplastic cortex in 65% of our patients. Resective surgery can eliminate or significantly reduce seizure ...
Tópico(s): Fetal and Pediatric Neurological Disorders
1994 - Wiley | Epilepsia
Produção Nacional
Revisado por pares
Imad Najm, Dennis Lal, Mario Alonso‐Vanegas, Fernando Cendes, Íscia Lopes‐Cendes, André Palmini, Eliseu Paglioli, Harvey B. Sarnat, Christopher A. Walsh, Samuel Wiebe, Eleonora Aronica, Stéphanie Baulac, Roland Coras, Katja Kobow, J. Helen Cross, Rita Garbelli, Hans Holthausen, Karl Rössler, Maria Thom, Assam El‐Osta, Jeong Ho Lee, Hajime Miyata, Renzo Guerrini, Yueshan Piao, Dong Zhou, Ingmar Blümcke,
Abstract Ongoing challenges in diagnosing focal cortical dysplasia (FCD) mandate continuous research and consensus agreement to improve disease definition and classification. An International League Against Epilepsy (ILAE) Task Force (TF) reviewed the FCD classification of 2011 to identify existing gaps and provide a timely update. The following methodology was applied to achieve this goal: a survey of published literature indexed with ((Focal Cortical Dysplasia) AND (epilepsy)) between 01/01/2012 and ...
Tópico(s): Genetics and Neurodevelopmental Disorders
2022 - Wiley | Epilepsia
Produção Nacional
Revisado por pares
Thomas Frigeri, Eliseu Paglioli, Ricardo Bernardi Soder, William Alves Martins, Rafael Paglioli, Rita Mattiello, Ricardo Paganin, André Palmini,
In a previous proof of concept study, selective posterior callosotomy achieved similar degree of control of drop attacks as total callosotomy, while sparing prefrontal interconnectivity. The present study aims to confirm this finding in a larger cohort and to provide anatomical and prognostic data.Fifty-one patients with refractory drop attacks had selective posterior callosotomy and prospective follow up for a mean of 6.4 years. Twenty-seven patients had post-operative magnetic resonance imaging ( ...
Tópico(s): Epilepsy research and treatment
2021 - Elsevier BV | Epilepsy Research
Produção Nacional
Revisado por pares
Gislaine Baroni, William Alves Martins, Vitória Lucietto Piccinini, Marcelo Pereira da Rosa, Luciano de Paola, Eliseu Paglioli, Regina Margis, André Palmini,
To investigate demographic, epidemiologic and psychiatric features suggestive of the coexistence epilepsy (ES) and psychogenic nonepileptic seizures (PNES) that may contribute to precocious suspicion of the association. In this exploratory study, all patients older than 16 years admitted to prolonged video-electroencephalogram monitoring were evaluated about demographic, epileptological and psychiatric features. Detailed psychiatric assessment using M.I.N.I.-plus 5.0, Beck Anxiety Inventory, Beck ...
Tópico(s): Schizophrenia research and treatment
2018 - Elsevier BV | Journal of Psychosomatic Research
Produção Nacional
Revisado por pares
Franciele Kipper, Andrew Oliveira Silva, André Luis Marc, Gláucia Confortin, Augusto Valadão Junqueira, Eliseu Paglioli Neto, Guido Lenz,
Tópico(s): Microtubule and mitosis dynamics
2017 - Springer Science+Business Media | Investigational New Drugs
Produção Nacional
Revisado por pares
Gislaine Baroni, Vitória Lucietto Piccinini, William Alves Martins, Luciano de Paola, Eliseu Paglioli, Regina Margis, André Palmini,
Abstract Purpose Epileptic seizures (ES) have many mimickers, perhaps the most relevant being psychogenic nonepileptic seizures (PNES). The picture is even more challenging when PNES are associated with ES in a given patient. The aim of this research paper was to delineate the demographic, epileptological and psychiatric profile of that specific population. Methods A systematic review was carried out from 2000 to 2015 for articles in English, French, Italian, Spanish and Portuguese in PUBMED and EMBASE. Cohort ...
Tópico(s): Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
2016 - Elsevier BV | Seizure
Produção Nacional
Revisado por pares
Eliseu Paglioli, William Alves Martins, Ney Azambuja, Mirna Wetters Portuguez, Thomas Frigeri, Larissa Pinos, Ricardo Lutzky Saute, Cora Salles, João Rubião Hoefel, Ricardo Bernardi Soder, Jaderson Costa da Costa, Marta Hemb, Tom Theys, André Palmini,
To evaluate a novel approach to control epileptic drop attacks through a selective posterior callosotomy, sparing all prefrontal interconnectivity.Thirty-six patients with refractory drop attacks had selective posterior callosotomy and prospective follow-up for >4 years. Falls, episodes of aggressive behavior, and IQ were quantified. Autonomy in activities of daily living, axial tonus, and speech generated a functional score ranging from 0 to 13. Subjective effect on patient well-being and caregiver ...
Tópico(s): Neonatal and fetal brain pathology
2016 - Lippincott Williams & Wilkins | Neurology
Produção Nacional
Revisado por pares
Thomas Frigeri, Eliseu Paglioli, Evandro de Oliveira, Albert L. Rhoton,
OBJECT Central Lobe consists of the pre- and postcentral gyri on the lateral surface and the Paracentral Lobule on the medial surface and corresponds to the sensorimotor cortex. The objective of the present study was to define the neural features, craniometric relationships, arterial supply, and venous drainage of the central lobe. METHODS Cadaveric hemispheres dissected using microsurgical techniques provided the material for this study. RESULTS The coronal suture is closer to the precentral gyrus ...
Tópico(s): Head and Neck Surgical Oncology
2015 - American Association of Neurological Surgeons | Journal of neurosurgery
Produção Nacional
Revisado por pares
Wim Naets, J. van Loon, Eliseu Paglioli, Wim Van Paesschen, André Palmini, Tom Theys,
Precise anatomical knowledge of the structure of the corpus callosum is important in split-brain research and during neurosurgical procedures sectioning the callosum. According to the classic literature, commissural fibers connecting the motor cortex are situated in the anterior part of the corpus callosum. On the other hand, more recent imaging studies using diffusion tensor imaging indicate a more posterior topography of callosal fibers connecting motor areas. Topographical knowledge is especially ...
Tópico(s): Neurological disorders and treatments
2015 - Springer Science+Business Media | Brain Structure and Function
Produção Nacional
Revisado por pares
William Alves Martins, Eliseu Paglioli, Marta Hemb, André Palmini,
Subcortical epilepsy has been a controversial issue, partially settled by evidence showing seizure generation in hypothalamic hamartomas and also by reports of seizures caused by cerebellar lesions. We report 4-year-old girl with right hemifacial seizures and autonomic phenomena, in whom MRI showed an irregular mass in the right cerebellar peduncle. Despite several unremarkable video-EEG recordings, seizure origin in the lesion was hypothesized. Complete resection was feasible, histopathology showed ...
Tópico(s): Neurological and metabolic disorders
2015 - Springer Science+Business Media | The Cerebellum
Produção Nacional
Revisado por pares
Lara Jehi, André Palmini, Usha Aryal, Roland Coras, Eliseu Paglioli,
Cavernous cerebral malformations (CCMs) are a well-defined epilepsy-associated pathology. They represent lesions/conglomerates of abnormally configured vessels leading to seizures either as a result of physiological changes affecting the cerebral cortex immediately surrounding the CCM (an epileptogenic mechanism that is relevant for both temporal and extratemporal lesions), or as a result of promoting epileptogenicity in remote but anatomo-functionally connected brain regions (a mechanism that is particularly ...
Tópico(s): Epilepsy research and treatment
2014 - Springer Science+Business Media | Acta Neuropathologica
Produção Nacional
Revisado por pares
Imad Najm, Lara Jehi, André Palmini, Jorge González-Martínez, Eliseu Paglioli, William Bingaman,
Summary Epilepsy surgery is an accepted treatment option in patients with medically refractory focal epilepsy. Despite various advances in recording and localization noninvasive and invasive techniques (including electroencephalography ( EEG ), magnetic resonance imaging ( MRI ), positron emission tomography ( PET ), single photon emission computed tomography ( SPECT ), magnetoencephalography ( MEG ), subdural grids, depth electrodes, and so on), the seizure outcome following surgical resection remains suboptimal in a significant ...
Tópico(s): Memory and Neural Mechanisms
2013 - Wiley | Epilepsia
Produção Nacional
Revisado por pares
André Palmini, Eliseu Paglioli, Vinícius Duval da Silva,
Summary Developmental tumors often lead to refractory partial seizures and constitute a well‐defined, surgically remediable epilepsy syndrome. Dysplastic features are often associated with these tumors, and their significance carries both practical and conceptual relevance. If associated focal cortical dysplasia ( FCD ) relates to the extent of the epileptogenic tissue, then presurgical evaluation and surgical strategies should target both the tumor and the surrounding dyslaminated cortex. Furthermore, ...
Tópico(s): Fetal and Pediatric Neurological Disorders
2013 - Wiley | Epilepsia
Produção Nacional
Revisado por pares
Marta Hemb, André Palmini, Eliseu Paglioli, Eduardo Paglioli, Jaderson Costa da Costa, Ney Azambuja, Mirna Wetters Portuguez, Verena Subtil Viuniski, Linda Booij, Magda Lahorgue Nunes,
To evaluate the very long-term clinical outcome of surgery for mesial temporal lobe epilepsy and unilateral hippocampal sclerosis (MTLE/HS) without atypical features. The impact of surgical technique and postoperative reduction of medication on this outcome was investigated.Prospective longitudinal cohort follow-up study for up to18 years.Epilepsy surgery centre in a university hospital.108 patients who underwent unilateral MTLE/HS.Surgery for MTLE/HS.Engel classification (I). Clinical evaluations ...
Tópico(s): Neuroscience and Neuropharmacology Research
2013 - BMJ | Journal of Neurology Neurosurgery & Psychiatry
Produção Nacional
Revisado por pares
Eliseu Paglioli, André Palmini, Mirna Wetters Portuguez, Eduardo Paglioli, Ney Azambuja, Jaderson Costa da Costa, Hélio Fernandes da Silva Filho, José Victor Martinez, João Rubião Hoeffel,
Object The aim of this study was to compare seizure and memory outcome in patients with medically refractory mesial temporal lobe epilepsy due to hippocampal sclerosis (MTLE/HS) treated using an anterior temporal lobectomy (ATL) or a selective amygdalohippocampectomy (SA). Methods Surgical outcome data were prospectively collected for 2 to 11 years in 161 consecutive patients with MTLE/HS. Eighty patients underwent an ATL and 81 an SA. Seizure control achieved with each technique was compared using ...
Tópico(s): Cerebrospinal fluid and hydrocephalus
2006 - American Association of Neurological Surgeons | Journal of neurosurgery
Produção Nacional
Revisado por pares
André Palmini, Péter Halász, Ingrid E. Scheffer, Yukitoshi Takahashi, Ángeles Pérez Jiménez, François Dubeau, Frédérick Andermann, Eliseu Paglioli‐Neto, Jaderson Costa da Costa, Felix Rosenow, Brita Fritsch,
Summary: Purpose: Malformations of cortical development (MCDs) are usually highly epileptogenic, and their hyperexcitability could facilitate the occurrence of reflex seizures. We sought to characterize reflex seizures in patients with MCDs and refractory epilepsy. Methods: Clinical, electrographic, and neuroimaging data were reviewed in eight patients with MCDs who had reflex seizures reproduced during presurgical evaluation. Results: All eight patients had both reflex and spontaneous seizures. ...
Tópico(s): Neurological disorders and treatments
2005 - Wiley | Epilepsia
Produção Nacional
Revisado por pares
Eliseu Paglioli, André Palmini, Eduardo Paglioli, Jaderson Costa da Costa, Mirna Wetters Portuguez, José Victor Martinez, María Elisa Calcagnotto, João Rubião Hoefel, Sérgio Fernando Raupp, Lígia Maria Barbosa-Coutinho,
Surgical results in patients with mesial temporal lobe epilepsy due to hippocampal sclerosis (MTLE/HS) are often reported in conjunction with other etiologies of TLE.We prospectively collected surgical outcome data for 2 to 11 years for 134 consecutive patients who specifically had MTLE and unilateral HS, according to magnetic resonance imaging (MRI) and confirmed by histopathology. Sixty-five had postoperative neuropsychological testing. Outcome was analyzed by using Engel's classification (a) through ...
Tópico(s): Pharmacological Effects and Toxicity Studies
2004 - Wiley | Epilepsia
Produção Nacional
Revisado por pares
Daniel M. Branco, Tatiana M. Coelho, Bianca M. Branco, Letícia Petersen Schmidt, María Elisa Calcagnotto, Mirna Wetters Portuguez, Eliseu Paglioli Neto, Eduardo Paglioli, André Palmini, José Viana Lima, Jaderson Costa da Costa,
The purpose of this study was to assess the cortical representation of sensorimotor functions in patients undergoing perirolandic epilepsy surgery, focusing on somatotopy, mosaicism, and variability of function in relation to the classic motor homunculus. The authors studied 36 patients in whom intraoperative or extraoperative electrical cortical stimulation to map motor functions was performed. A computer program was devised to register electrode number, stimulation parameters, and response to ...
Tópico(s): Functional Brain Connectivity Studies
2003 - Lippincott Williams & Wilkins | Journal of Clinical Neurophysiology
Produção Nacional
Revisado por pares
André Palmini, Eliseu Paglioli‐Neto, José Montes, Jean‐Paul Farmer,
The growing interest in the association between hypothalamic hamartomas (HH), epilepsy and behavioural abnormalities witnessed in recent years, has led to significant progress regarding the clinical presentations, pathophysiology and management of this entity. Patients with these lesions may occupy different points within a spectrum of severity of the epileptic and behavioural disorder, and may dynamically progress toward more malignant epilepsies with time. The role of the subcortical lesion in ...
Tópico(s): Hedgehog Signaling Pathway Studies
2003 - Wiley | Epileptic Disorders
Produção Nacional
Revisado por pares
André Palmini, C Chandler, Frédérick Andermann, Jaderson Costa da Costa, Eliseu Paglioli‐Neto, Charles E. Polkey, Bernard Rosenblatt, J. Montes, José Vicente Balaguer Martínez, Jean‐Pierre Farmer, Benjamin Sinclair, Keith Aronyk, Eduardo Paglioli, L. M. Barbosa Coutinho, Sérgio Fernando Raupp, Mirna Wetters Portuguez,
Background: Patients with hypothalamic hamartomas (HH) often have severe refractory epilepsy, incapacitating behavioral abnormalities, and cognitive decline. Attempts to control the seizure disorder by resection of apparently epileptogenic mesial temporal or other cortical structures have failed consistently. Objective: To report a series of 13 patients in whom the hamartoma itself was resected. Methods: All patients underwent preoperative evaluation between ages 2 and 33 years and had subtotal or complete ...
Tópico(s): Genetics and Neurodevelopmental Disorders
2002 - Lippincott Williams & Wilkins | Neurology
Produção Nacional
Revisado por pares
Andrea Bernasconi, Víctor Manuel Martínez Bullé Goyri, Pedro Rosa‐Neto, Daniela D’Agostino, Neda Bernasconi, Samuel F. Berkovic, Mark T. Mackay, A. Simon Harvey, André Palmini, Jaderson Costa da Costa, Eliseu Paglioli, H.I. Kim, Mary Connolly, André Olivier, François Dubeau, E. Andermann, Renzo Guerrini, W.W. Whisler, Leyla de Toledo‐Morrell, Frank Morrell, Frédérick Andermann,
Summary: Purpose: To analyze the results of surgical treatment of intractable epilepsy in patients with subcortical band heterotopia, or double cortex syndrome, a diffuse neuronal migration disorder. Methods: We studied eight patients (five women) with double cortex syndrome and intractable epilepsy. All had a comprehensive presurgical evaluation including prolonged video‐EEG recordings and magnetic resonance imaging (MRI). Results: All patients had partial seizures, with secondary generalization ...
Tópico(s): Cerebrospinal fluid and hydrocephalus
2001 - Wiley | Epilepsia
Produção Nacional
Daniel Rodrigo Marinowic, Fernanda Majolo, Alessandra Deise Sebben, Vinícius Duval da Silva, Tiago Giuliani Lopes, Eliseu Paglioli, André Palmini, Denise Cantarelli Machado, Jaderson Costa da Costa,
Focal cortical dysplasia (FCD) is caused by numerous alterations, which can be divided into abnormalities of the cortical architecture and cytological variations; however, the exact etiology of FCD remains unknown. The generation of induced pluripotent stem cells (iPSCs) from the cells of patients with neurological diseases, and their subsequent tissue‑specific differentiation, serves as an invaluable source for testing and studying the initial development and subsequent progression of diseases associated ...
Tópico(s): Neurogenesis and neuroplasticity mechanisms
2017 - Spandidos Publishing | Molecular Medicine Reports
Produção Nacional
Revisado por pares
Marlise de Castro Ribeiro, Lígia Maria Barbosa-Coutinho, Fabiana Eloisa Mugnol, Arlete Hilbig, André Palmini, Jaderson Costa da Costa, Eliseu Paglioli Neto, Eduardo Paglioli,
Hippocampal sclerosis (HS) is the commonest pathology in epileptic patients undergoing temporal lobe epilepsy surgery. Beside, there are an increased density of corpora amylacea (CA) founded in 6 to 63% of those cases. OBJECTIVE: verify the presence of CA and the clinical correlates of their occurrence in a consective series of patients undergoing temporal surgery with diagnosis of HS. METHOD: We reviewed 72 hippocampus specimens from January 1997 to July 2000. Student's t test for independent, samples, ...
Tópico(s): Neurological disorders and treatments
2003 - Thieme Medical Publishers (Germany) | Arquivos de Neuro-Psiquiatria
Lígia Maria Barbosa-Coutinho, Arlete Hilbig, María Elisa Calcagnotto, Eduardo Paglioli, Eliseu Paglioli‐Neto, Jaderson Costa da Costa, André Palmini, Élbir C. De Paula,
Fazemos uma análise das alterações neuropatológicas encontradas em 300 casos consecutivos de cirurgia da epilepsia realizadas durante período de 6 anos. O material foi predominantemente de lobo temporal (70,33%), sendo a esclerose hipocampal o diagnóstico mais frequente (44%), seguido das neoplasias (15%) e dos distúrbios da migração neuronal (10%). Os tumores mais frequentes foram o ganglioglioma (42,22%) e tumor neuroepitelial disembrioplástico (20%). Segue revisão dos diagnósticos mais comuns em epilepsia ...
Tópico(s): Glycogen Storage Diseases and Myoclonus
1999 - Thieme Medical Publishers (Germany) | Arquivos de Neuro-Psiquiatria
Produção Nacional
Revisado por pares
William Alves Martins, Alice Becker Teixeira, Thomas Frigeri, Eliseu Paglioli,
Subdural hematoma (SH) is a neurosurgical emergency, usually caused by head trauma. Non-traumatic causes include aneurysm or arterial–venous malformation rupture, coagulopathy and others. We report the case of a 66 year-old man who developed apparently unprovoked signs of increased intracranial pressure. Brain computed tomography scan showed an acute spontaneous SH, surgically treated. Throughout surgery, a ruptured cortical artery with intensive bleeding appeared and was cauterized. After surgery, ...
Tópico(s): Cerebral Venous Sinus Thrombosis
2014 - Elsevier BV | Interdisciplinary Neurosurgery
Produção Nacional
Revisado por pares
Tharick A. Pascoal, Eliseu Paglioli, André Palmini, Rafael ̈Pombo Menezes, Martin Staudt,
Summary Hemispherectomy often leads to a loss of contralateral hand function. In some children with congenital hemiparesis, however, paretic hand function remains unchanged. An immediate improvement of hand function has never been reported. A 17‐year‐old boy with congenital hemiparesis and therapy‐refractory seizures due to a large infarction in the territory of the middle cerebral artery underwent epilepsy surgery. Intraoperatively, electrical cortical stimulation of the affected hemisphere demonstrated ...
Tópico(s): Neonatal and fetal brain pathology
2013 - Wiley | Epilepsia
Produção Nacional
Revisado por pares
Lucas Porcello Schilling, Renata R. Kieling, Tharick A. Pascoal, Hyoung‐Ihl Kim, Min Cheol Lee, Yun‐Hee Kim, Eliseu Paglioli, Pedro Rosa‐Neto, Jaderson Costa da Costa, André Palmini,
Interest in the association of epilepsy and pseudobulbar palsy was rekindled since the identification through magnetic resonance imaging (MRI) of bilateral perisylvian polymicrogyria (PMG). Seizures are often intractable, but resective epilepsy surgery has not been recommended. However, a similar clinical picture can be encountered in patients with bilateral perisylvian destructive lesions, which fit the description of ulegyria (ULG). We report a series of patients with epilepsy and pseudobulbar palsy ...
Tópico(s): Ophthalmology and Eye Disorders
2013 - Wiley | Epilepsia
Produção Nacional
Revisado por pares
Simone Denise Salamoni, Jaderson Costa da Costa, Mário Sérgio Palma, Katsuhiro Konno, Ken‐ichi Nihei, Ney Azambuja, Eliseu Paglioli Neto, Gianina Teribele Venturin, Andréa Alencar Tavares, Daniela Souza de Abreu, Ricardo Vaz Breda,
We analyzed the effect of the acylpolyaminetoxin JSTX-3 on the epileptogenic discharges induced by perfusion of human hippocampal slices with artificial cerebrospinal fluid lacking Mg2+ or N-methyl-D-aspartate. Hippocampi were surgically removed from patients with refractory medial temporal lobe epilepsy, sliced in the surgical room and taken to the laboratory immersed in normal artificial cerebrospinal fluid. Epileptiform activity was induced by perfusion with Mg2+-free artificial cerebrospinal ...
Tópico(s): Epilepsy research and treatment
2005 - Lippincott Williams & Wilkins | Neuroreport
Produção Nacional
Revisado por pares
Daniel Rodrigo Marinowic, Gabriele Zanirati, Fernando Antônio Costa Xavier, Fábio Jean Varella, Sofia Prates da Cunha de Azevedo, Isadora Machado Ghilardi, Normando G Pereira-Neto, Marco Koff, Eliseu Paglioli, André Palmini, José G. Abreu, Denise Cantarelli Machado, Jaderson Costa da Costa,
Abstract Background Focal cortical dysplasia (FCD) is a malformation of cortical development that causes medical refractory seizures, and one of the main treatments may be surgical resection of the affected area of the brain. People affected by FCD may present with seizures of variable severity since childhood. Despite many medical treatments available, only surgery can offer cure. The pathophysiology of the disease is not yet understood; however, it is known that several gene alterations may play ...
Tópico(s): Hedgehog Signaling Pathway Studies
2023 - BioMed Central | BMC Neurology