Tobias Kammann, Curtis Cai, Takuya Sekine, Elli Mouchtaridi, Caroline Boulouis, Vera Nilsén, Olga Rivera‐Ballesteros, Thomas Müller, Yu Gao, Elisa J.M. Raineri, Akhirunnesa Mily, Sarah Adamo, Christian M. Constantz, Julia Niessl, Whitney Weigel, Efthymia Kokkinou, Christopher T. Stamper, Anne Marchalot, John Bassett, Sabrina Antunes Ferreira, Inga Rødahl, Nicole Wild, Demi Brownlie, Christopher A. Tibbitt, Jeffrey Y. W. Mak, David P. Fairlie, Edwin Leeansyah, Jakob Michaëlsson, Nicole Marquardt, Jenny Mjösberg, Carl Jorns, Marcus Buggert, Johan K. Sandberg,
Mucosal-associated invariant T (MAIT) cells are unconventional T cells that recognize microbial riboflavin pathway metabolites presented by evolutionarily conserved MR1 molecules. We explored the human MAIT cell compartment across organ donor–matched blood, barrier, and lymphoid tissues. MAIT cell population size was donor dependent with distinct tissue compartmentalization patterns and adaptations: Intestinal CD103 + resident MAIT cells presented an immunoregulatory CD39 high CD27 low profile, whereas ...
Tópico(s): Cytomegalovirus and herpesvirus research
2024 - American Association for the Advancement of Science | Science Immunology