Lucy C. Ward, Hannah V. McCue, Daniel J. Rigden, Neil M. Kershaw, Chloe Ashbrook, Harry Hatton, Ellie Goulding, James R. Johnson, Andrew J. Carnell,
Carboxyl methyltransferase (CMT) enzymes catalyse the biomethylation of carboxylic acids under aqueous conditions and have potential for use in synthetic enzyme cascades. Herein we report that the enzyme FtpM from Aspergillus fumigatus can methylate a broad range of aromatic mono- and dicarboxylic acids in good to excellent conversions. The enzyme shows high regioselectivity on its natural substrate fumaryl-l-tyrosine, trans, trans-muconic acid and a number of the dicarboxylic acids tested. Dicarboxylic ...
Tópico(s): Microbial Metabolic Engineering and Bioproduction
2022 - Wiley | Angewandte Chemie International Edition
... I Need Your Love” by Calvin Harris ft. Ellie Goulding (2012), “La La La” by Naughty Boy ft. ...
Tópico(s): Neuroscience and Music Perception
2022 - Society for Music Theory | Music Theory Online
Lucy C. Ward, Ellie Goulding, Daniel J. Rigden, Faye E. Allan, Alessandro Pellis, Harry Hatton, Georg M. Guebitz, J. Enrique Salcedo-Sora, Andrew J. Carnell,
FtpM from Aspergillus fumigatus was the first carboxyl methyltransferase reported to catalyse the dimethylation of dicarboxylic acids. Here the creation of mutant R166M that can catalyse the quantitative conversion of bio-derived 2,5-furandicarboxylic acid (FDCA) to its dimethyl ester (FDME), a bioplastics precursor, was reported. Wild type FtpM gave low conversion due to its reduced catalytic efficiency for the second methylation step. An AlphaFold 2 model revealed a highly electropositive active ...
Tópico(s): Biofuel production and bioconversion
2023 - Wiley | ChemSusChem
Anthony Lamb, Rhys E. Green, Ian J. Bateman, Mark Broadmeadow, Toby J. A. Bruce, Jennifer Burney, Pete D. Carey, David R. Chadwick, Ellie Crane, Rob H. Field, K. W. T. Goulding, Howard Griffiths, Astley Hastings, Tim Kasoar, D. R. Kindred, Ben Phalan, John A. Pickett, Pete Smith, E. Wall, Erasmus K. H. J. zu Ermgassen, Andrew Balmford,
Reducing agricultural emissions during times of increasing food demand is a challenge. Research, using the UK as an example, now shows the technical mitigation potential of increasing agricultural yields, reducing farmed area and restoring habitats. Greenhouse gas emissions from global agriculture are increasing at around 1% per annum, yet substantial cuts in emissions are needed across all sectors1. The challenge of reducing agricultural emissions is particularly acute, because the reductions achievable ...
Tópico(s): Environmental Impact and Sustainability
2016 - Nature Portfolio | Nature Climate Change
Amitha Domalpally, Samuel A. Whittier, Qing Pan, Dana Dabelea, Christine Darwin, William C. Knowler, Christine G. Lee, José A. Luchsinger, Neil H. White, Emily Y. Chew, George A. Bray, Kishore M. Gadde, Iris W. Culbert, Jennifer Arceneaux, Annie Chatellier, Amber Dragg, Catherine M. Champagne, Crystal Duncan, Barbara Eberhardt, Frank L. Greenway, Fonda G. Guillory, April A. Herbert, Michael L. Jeffirs, Betty M. Kennedy, Erma Levy, Monica Lockett, Jennifer C. Lovejoy, Laura H. Morris, Lee E. Melancon, Donna H. Ryan, Deborah A. Sanford, Kenneth G. C. Smith, Lisa L. Smith, Julia A. St. Amant, Richard T. Tulley, Paula C. Vicknair, Donald Williamson, J. J. Zachwieja, Kenneth S. Polonsky, Janet Tobian, David A. Ehrmann, Margaret J. Matulik, Karla A. Temple, Bart Clark, Kirsten Czech, Catherine DeSandre, Brittnie Dotson, Ruthanne Hilbrich, Wylie McNabb, Ann R. Semenske, F. José, Kevin Furlong, Barry J. Goldstein, Pamela G. Watson, Kellie A. Smith, Jewel Mendoza, Marsha Simmons, Wendi Wildman, Renee Liberoni, John Spandorfer, Constance Pepe, Richard P. Donahue, Ronald Goldberg, Ronald J. Prineas, Jeanette Calles, Anna Giannella, Patricia M. Rowe, Juliet Sanguily, Paul Cassanova-Romero, Sumaya Castillo-Florez, Hermes Flórez, Rajesh Garg, Lascelles Kirby, Olga Lara, Carmen Larreal, Valerie McLymont, Jadell Mendez, Arlette C. Perry, Patrice G. Saab, Bertha Veciana, Steven M. Haffner, Helen P. Hazuda, Maria G. Montez, Kathy Hattaway, Juan Isaac, Carlos Lorenzo, Arlene Martinez, Monica Salazar, Tatiana Walker, Richard F. Hamman, Patricia V. Nash, Sheila C. Steinke, Lisa Testaverde, Jennifer Truong, Denise Anderson, Larry B. Ballonoff, Alexis Bouffard, Brian C. Bucca, B. Ned Calonge, Lynne Delve, Martha Farago, James O. Hill, Shelley R. Hoyer, Tonya Jenkins, Bonnie T. Jortberg, Dione Lenz, Marsha Miller, Thomas Nilan, Leigh Perreault, David W. Price, Judith G. Regensteiner, Emily B. Schroeder, Helen Seagle, Carissa M. Smith, Brent VanDorsten, Edward S. Horton, Medha Munshi, Kathleen E. Lawton, Sharon D. Jackson, Catherine S. Poirier, Kati Swift, Ronald A. Arky, Marybeth Bryant, Jacqueline P. Burke, Enrique Caballero, Karen M. Callaphan, Barbara Fargnoli, Therese Franklin, Om P Ganda, Ashley Guidi, Mathew Guido, Alan M. Jacobsen, Lyn M. Kula, Margaret Kocal, Lori Lambert, Sarah Ledbury, Maureen A. Malloy, Roeland J.W. Middelbeek, Maryanne Nicosia, Cathryn F. Oldmixon, Jocelyn Pan, Marizel Quitingon, Riley Rainville, Stacy Rubtchinsky, Ellen W. Seely, Jessica Sansoucy, Dana Schweizer, Donald C. Simonson, Fannie Smith, Caren G. Solomon, Jeanne Spellman, James H. Warram, Steven E. Kahn, Basma Fattaleh, Brenda K. Montgomery, Celeste Colegrove, Wilfred Y. Fujimoto, Robert H. Knopp, Edward W. Lipkin, Michelle Marr, Ivy Morgan-Taggart, Anne Murillo, Kayla O’Neal, Dace Trence, Lonnese Taylor, April Thomas, Elaine C. Tsai, Samuel Dagogo‐Jack, Abbas E. Kitabchi, Mary E. Murphy, Laura J. Taylor, Jennifer Dolgoff, William B. Applegate, Michael Bryer‐Ash, Debra Clark, Sandra L. Frieson, Uzoma N. Ibebuogu, Raed Imseis, Helen Lambeth, Lynne C. Lichtermann, Hooman Oktaei, Harriet Ricks, Lily M.K. Rutledge, Amy R. Sherman, Clara M. Smith, Judith E. Soberman, Beverly Williams-Cleaves, Avnisha Patel, Ebenezer Nyenwe, Ethel Faye Hampton, Boyd E. Metzger, Mark E. Molitch, Mariana K. Johnson, Daphne T. Adelman, Catherine Behrends, Michelle Cook, Marian L. Fitzgibbon, Mimi M. Giles, Deloris Heard, Cheryl K.H. Johnson, Diane Larsen, Anne Lowe, Megan Lyman, David D. McPherson, Samsam C. Penn, Thomas Pitts, Renee Reinhart, Susan Roston, Pamela A. Schinleber, Amisha Wallia, David M. Nathan, Charles McKitrick, Heather Turgeon, Mary Larkin, Marielle Mugford, Kathy Abbott, Ellen Anderson, Laurie Bissett, Kristy Bondi, Enrico Cagliero, José C. Florez, Linda M. Delahanty, Valerie Goldman, Elaine Grassa, Lindsery Gurry, Kali D’Anna, Fernelle Leandre, Peter Lou, Alexandra Poulos, Elyse Raymond, Valerie Ripley, Christine Stevens, Beverly Tseng, Jerrold M. Olefsky, Elizabeth Barrett‐Connor, Sunder Mudaliar, Maria Rosario G. Araneta, Mary Lou Carrion-Petersen, Karen Vejvoda, Sarah Bassiouni, Madeline Beltran, Lauren N. Claravall, Jonalle M. Dowden, Steven V. Edelman, Pranav S. Garimella, Robert R. Henry, Javiva Horne, Marycie Lamkin, Simona Szerdi Janesch, Diana Leos, William H. Polonsky, Rosa Ruiz, Jean Louise M. Smith, Jennifer Torio-Hurley, F. Xavier Pi‐Sunyer, Jane E. Lee, Susan Hagamen, David B. Allison, Nnenna Agharanya, Nancy J. Aronoff, Maria Baldo, Jill P. Crandall, Sandra T. Foo, José A. Luchsinger, Carmen Pal, Kathy Parkes, Mary Beth Pena, Ellen S. Rooney, Gretchen E.H. Van Wye, Kristine A. Viscovich, Mary de Groot, David G. Marrero, Kieren J. Mather, Melvin Prince, Susie M. Kelly, Marcia A. Jackson, Gina McAtee, Paula Putenney, Ronald T. Ackermann, Carolyn M. Cantrell, Yolanda F. Dotson, Edwin S. Fineberg, Megan Fultz, John Guare, Angela Hadden, James M. Ignaut, Marion S. Kirkman, Erin O’Kelly Phillips, Kisha L. Pinner, Beverly D. Porter, Paris Roach, Nancy Rowland, Madelyn L. Wheeler, Vanita R. Aroda, Michelle Magee, Robert E. Ratner,
Age-related macular degeneration (AMD) is a leading cause of blindness with no treatment available for early stages. Retrospective studies have shown an association between metformin and reduced risk of AMD.
American Medical Association
Christine G. Lee, Brandy M. Heckman‐Stoddard, Dana Dabelea, Kishore M. Gadde, David A. Ehrmann, Leslie Ford, Philip C. Prorok, Edward J. Boyko, F. Xavier Pi‐Sunyer, Amisha Wallia, William C. Knowler, Jill P. Crandall, Marinella Temprosa, George A. Bray, Kishore M. Gadde, Iris W. Culbert, Jennifer Arceneaux, Annie Chatellier, Amber Dragg, Catherine M. Champagne, Crystal Duncan, Barbara Eberhardt, Frank L. Greenway, Fonda G. Guillory, April A. Herbert, Michael L. Jeffirs, Betty M. Kennedy, Erma Levy, Monica Lockett, Jennifer C. Lovejoy, Laura H. Morris, Lee E. Melancon, Donna H. Ryan, Deborah A. Sanford, Kenneth G. C. Smith, Lisa L. Smith, Julia A. St. Amant, Richard T. Tulley, Paula C. Vicknair, Donald Williamson, J. J. Zachwieja, Kenneth S. Polonsky, Janet Tobian, David A. Ehrmann, Margaret J. Matulik, Karla A. Temple, Bart Clark, Kirsten Czech, Catherine DeSandre, Brittnie Dotson, Ruthanne Hilbrich, Wylie McNabb, Ann R. Semenske, F. José, Kevin Furlong, Barry J. Goldstein, Pamela G. Watson, Kellie A. Smith, Jewel Mendoza, Marsha Simmons, Wendi Wildman, Renee Liberoni, John Spandorfer, Constance Pepe, Richard P. Donahue, Ronald Goldberg, Ronald J. Prineas, Jeanette Calles, Anna Giannella, Patricia M. Rowe, Juliet Sanguily, Paul Cassanova-Romero, Sumaya Castillo-Florez, Hermes Flórez, Rajesh Garg, Lascelles Kirby, Olga Lara, Carmen Larreal, Valerie McLymont, Jadell Mendez, Arlette C. Perry, Patrice G. Saab, Bertha Veciana, Steven M. Haffner, Helen P. Hazuda, Maria G. Montez, Kathy Hattaway, Juan Isaac, Carlos Lorenzo, Arlene Martinez, Monica Salazar, Tatiana Walker, Dana Dabelea, Richard F. Hamman, Patricia V. Nash, Sheila C. Steinke, Lisa Testaverde, Jennifer Truong, Denise Anderson, Larry B. Ballonoff, Alexis Bouffard, Brian C. Bucca, B. Ned Calonge, Lynne Delve, Martha Farago, James O. Hill, Shelley R. Hoyer, Tonya Jenkins, Bonnie T. Jortberg, Dione Lenz, Marsha Miller, Thomas Nilan, Leigh Perreault, David W. Price, Judith G. Regensteiner, Emily B. Schroeder, Helen Seagle, Carissa M. Smith, Brent VanDorsten, Edward S. Horton, Medha Munshi, Kathleen E. Lawton, Sharon D. Jackson, Catherine S. Poirier, Kati Swift, Ronald A. Arky, Marybeth Bryant, Jacqueline P. Burke, Enrique Caballero, Karen M. Callaphan, Barbara Fargnoli, Therese Franklin, Om P Ganda, Ashley Guidi, Mathew Guido, Alan M. Jacobsen, Lyn M. Kula, Margaret Kocal, Lori Lambert, Kathleen E. Lawton, Sarah Ledbury, Maureen A. Malloy, Roeland J.W. Middelbeek, Maryanne Nicosia, Cathryn F. Oldmixon, Jocelyn Pan, Marizel Quitingon, Riley Rainville, Stacy Rubtchinsky, Ellen W. Seely, Jessica Sansoucy, Dana Schweizer, Donald C. Simonson, Fannie Smith, Caren G. Solomon, Jeanne Spellman, James H. Warram, Steven E. Kahn, Basma Fattaleh, Brenda K. Montgomery, Celeste Colegrove, Wilfred Y. Fujimoto, Robert H. Knopp, Edward W. Lipkin, Michelle Marr, Ivy Morgan-Taggart, Anne Murillo, Kayla O’Neal, Dace Trence, Lonnese Taylor, April Thomas, Elaine C. Tsai, Samuel Dagogo‐Jack, Abbas E. Kitabchi, Mary E. Murphy, Laura J. Taylor, Jennifer Dolgoff, William B. Applegate, Michael Bryer‐Ash, Debra Clark, Sandra L. Frieson, Uzoma N. Ibebuogu, Raed Imseis, Helen Lambeth, Lynne C. Lichtermann, Hooman Oktaei, Harriet Ricks, Lily M.K. Rutledge, Amy R. Sherman, Clara M. Smith, Judith E. Soberman, Beverly Williams-Cleaves, Avnisha Patel, Ebenezer Nyenwe, Ethel Faye Hampton, Boyd E. Metzger, Mark E. Molitch, Mariana K. Johnson, Daphne T. Adelman, Catherine Behrends, Michelle Cook, Marian L. Fitzgibbon, Mimi M. Giles, Deloris Heard, Cheryl K.H. Johnson, Diane Larsen, Anne Lowe, Megan Lyman, David D. McPherson, Samsam C. Penn, Thomas Pitts, Renee Reinhart, Susan Roston, Pamela A. Schinleber, Amisha Wallia, David M. Nathan, Charles McKitrick, Heather Turgeon, Mary Larkin, Marielle Mugford, Kathy Abbott, Ellen Anderson, Laurie Bissett, Kristy Bondi, Enrico Cagliero, José C. Florez, Linda M. Delahanty, Valerie Goldman, Elaine Grassa, Lindsery Gurry, Kali D’Anna, Fernelle Leandre, Peter Lou, Alexandra Poulos, Elyse Raymond, Valerie Ripley, Christine Stevens, Beverly Tseng, Jerrold M. Olefsky, Elizabeth Barrett‐Connor, Sunder Mudaliar, Maria Rosario G. Araneta, Mary Lou Carrion-Petersen, Karen Vejvoda, Sarah Bassiouni, Madeline Beltran, Lauren N. Claravall, Jonalle M. Dowden, Steven V. Edelman, Pranav S. Garimella, Robert R. Henry, Javiva Horne, Marycie Lamkin, Simona Szerdi Janesch, Diana Leos, William H. Polonsky, Rosa Ruiz, Jean Louise M. Smith, Jennifer Torio-Hurley, F. Xavier Pi‐Sunyer, Blandine Laferrère, Jane E. Lee, Susan Hagamen, David B. Allison, Nnenna Agharanya, Nancy J. Aronoff, Maria Baldo, Jill P. Crandall, Sandra T. Foo, Kim Kelly-Dinham, José A. Luchsinger, Carmen Pal, Kathy Parkes, Mary Beth Pena, Ellen S. Rooney, Gretchen E.H. Van Wye, Kristine A. Viscovich, Mary de Groot, David G. Marrero, Kieren J. Mather, Melvin Prince, Susie M. Kelly, Marcia A. Jackson, Gina McAtee, Paula Putenney, Ronald T. Ackermann, Carolyn M. Cantrell, Yolanda F. Dotson, Edwin S. Fineberg, Megan Fultz, John Guare, Angela Hadden, James M. Ignaut, Marion S. Kirkman, Erin O’Kelly Phillips, Kisha L. Pinner,
OBJECTIVE To determine whether metformin or lifestyle modification can lower rates of all-cause and cause-specific mortality in the Diabetes Prevention Program and Diabetes Prevention Program Outcomes Study. RESEARCH DESIGN AND METHODS From 1996 to 1999, 3,234 adults at high risk for type 2 diabetes were randomized to an intensive lifestyle intervention, masked metformin, or placebo. Placebo and lifestyle interventions stopped in 2001, and a modified lifestyle program was offered to everyone, but ...
American Diabetes Association
Neil H. White, Qing Pan, William C. Knowler, Emily B. Schroeder, Dana Dabelea, Emily Y. Chew, Barbara Blodi, Ronald Goldberg, F. Xavier Pi‐Sunyer, Christine Darwin, Mathias Schlögl, David M. Nathan, George A. Bray, Kishore M. Gadde, Iris W. Culbert, Jennifer Arceneaux, Annie Chatellier, Amber Dragg, Catherine M. Champagne, Crystal Duncan, Barbara Eberhardt, Frank L. Greenway, Fonda G. Guillory, April A. Herbert, Michael L. Jeffirs, Betty M. Kennedy, Erma Levy, Monica Lockett, Jennifer C. Lovejoy, Laura H. Morris, Lee E. Melancon, Donna H. Ryan, Deborah A. Sanford, Kenneth G. C. Smith, Lisa L. Smith, Julia A. St. Amant, Richard T. Tulley, Paula C. Vicknair, Donald S. Williamson, J. J. Zachwieja, Kenneth S. Polonsky, Janet Tobian, David A. Ehrmann, Margaret J. Matulik, Karla A. Temple, Bart Clark, Kirsten Czech, Catherine DeSandre, Brittnie Dotson, Ruthanne Hilbrich, Wylie McNabb, Ann R. Semenske, F. José, Kevin Furlong, Barry J. Goldstein, Pamela G. Watson, Kellie A. Smith, Jewel Mendoza, Marsha Simmons, Wendi Wildman, Renee Liberoni, John Spandorfer, Constance Pepe, Richard P. Donahue, Ronald Goldberg, Ronald J. Prineas, Jeanette Calles, Anna Giannella, Patricia M. Rowe, Juliet Sanguily, Paul Cassanova-Romero, Sumaya Castillo-Florez, Hermes Flórez, Rajesh Garg, Lascelles Kirby, Olga Lara, Carmen Larreal, Valerie McLymont, Jadell Mendez, Arlette C. Perry, Patrice G. Saab, Bertha Veciana, Steven M. Haffner, Helen P. Hazuda, Maria G. Montez, Kathy Hattaway, Juan Isaac, Carlos Lorenzo, Arlene Martinez, Monica Salazar, Tatiana Walker, Dana Dabelea, Richard F. Hamman, Patricia V. Nash, Sheila C. Steinke, Lisa Testaverde, Jennifer Truong, Denise Anderson, Larry B. Ballonoff, Alexis Bouffard, Brian C. Bucca, B. Ned Calonge, Lynne Delve, Martha Farago, James O. Hill, Shelley R. Hoyer, Tonya Jenkins, Bonnie T. Jortberg, Dione Lenz, Marsha Miller, Thomas Nilan, Leigh Perreault, David W. Price, Judith G. Regensteiner, Emily B. Schroeder, Helen Seagle, Carissa M. Smith, Brent VanDorsten, Edward S. Horton, Medha Munshi, Kathleen E. Lawton, Sharon D. Jackson, Catherine S. Poirier, Kati Swift, Ronald A. Arky, Marybeth Bryant, Jacqueline P. Burke, Enrique Caballero, Karen M. Callaphan, Barbara Fargnoli, Therese Franklin, Om P Ganda, Ashley Guidi, Mathew Guido, Alan M. Jacobsen, Lyn M. Kula, Margaret Kocal, Lori Lambert, Kathleen E. Lawton, Sarah Ledbury, Maureen A. Malloy, Roeland J.W. Middelbeek, Maryanne Nicosia, Cathryn F. Oldmixon, Jocelyn Pan, Marizel Quitingon, Riley Rainville, Stacy Rubtchinsky, Ellen W. Seely, Jessica Sansoucy, Dana Schweizer, Donald C. Simonson, Fannie Smith, Caren G. Solomon, Jeanne Spellman, James H. Warram, Steven E. Kahn, Basma Fattaleh, Brenda K. Montgomery, Celeste Colegrove, Wilfred Y. Fujimoto, Robert H. Knopp, Edward W. Lipkin, Michelle Marr, Ivy Morgan-Taggart, Anne Murillo, Kayla O’Neal, Dace Trence, Lonnese Taylor, April Thomas, Elaine C. Tsai, Samuel Dagogo‐Jack, Abbas E. Kitabchi, Mary E. Murphy, Laura J. Taylor, Jennifer Dolgoff, William B. Applegate, Michael Bryer‐Ash, Debra Clark, Sandra L. Frieson, Uzoma N. Ibebuogu, Raed Imseis, Helen Lambeth, Lynne C. Lichtermann, Hooman Oktaei, Harriet Ricks, Lily M.K. Rutledge, Amy R. Sherman, Clara M. Smith, Judith E. Soberman, Beverly Williams-Cleaves, Avnisha Patel, Ebenezer Nyenwe, Ethel Faye Hampton, Boyd E. Metzger, Mark E. Molitch, Mariana K. Johnson, Daphne T. Adelman, Catherine Behrends, Michelle Cook, Marian L. Fitzgibbon, Mimi M. Giles, Deloris Heard, Cheryl K.H. Johnson, Diane Larsen, Anne Lowe, Megan Lyman, David D. McPherson, Samsam C. Penn, Thomas Pitts, Renee Reinhart, Susan Roston, Pamela A. Schinleber, Amisha Wallia, David M. Nathan, Charles McKitrick, Heather Turgeon, Mary Larkin, Marielle Mugford, Kathy Abbott, Ellen Anderson, Laurie Bissett, Kristy Bondi, Enrico Cagliero, José C. Florez, Linda M. Delahanty, Valerie Goldman, Elaine Grassa, Lindsery Gurry, Kali D’Anna, Fernelle Leandre, Peter Lou, Alexandra Poulos, Elyse Raymond, Valerie Ripley, Christine Stevens, Beverly Tseng, Jerrold M. Olefsky, Elizabeth Barrett‐Connor, Sunder Mudaliar, Maria Rosario G. Araneta, Mary Lou Carrion-Petersen, Karen Vejvoda, Sarah Bassiouni, Madeline Beltran, Lauren N. Claravall, Jonalle M. Dowden, Steven V. Edelman, Pranav S. Garimella, Robert R. Henry, Javiva Horne, Marycie Lamkin, Simona Szerdi Janesch, Diana Leos, William H. Polonsky, Rosa Ruiz, Jean Louise M. Smith, Jennifer Torio-Hurley, F. Xavier Pi‐Sunyer, Jane E. Lee, Susan Hagamen, David B. Allison, Nnenna Agharanya, Nancy J. Aronoff, Maria Baldo, Jill P. Crandall, Sandra T. Foo, José A. Luchsinger, Carmen Pal, Kathy Parkes, Mary Beth Pena, Ellen S. Rooney, Gretchen E.H. Van Wye, Kristine A. Viscovich, Mary de Groot, David G. Marrero, Kieren J. Mather, Melvin Prince, Susie M. Kelly, Marcia A. Jackson, Gina McAtee, Paula Putenney, Ronald T. Ackermann, Carolyn M. Cantrell, Yolanda F. Dotson, Edwin S. Fineberg, Megan Fultz, John Guare, Angela Hadden, James M. Ignaut, Marion S. Kirkman, Erin O’Kelly Phillips, Kisha L. Pinner, Beverly D. Porter, Paris Roach, Nancy Rowland,
To determine glycemic and nonglycemic risk factors that contribute to the presence of diabetic retinopathy (DR) before and after the onset of type 2 diabetes (T2D).During the Diabetes Prevention Program (DPP) and DPP Outcome Study (DPPOS), we performed fundus photography over time in adults at high risk for developing T2D, including after they developed diabetes. Fundus photographs were graded using the Early Treatment Diabetic Retinopathy Study (ETDRS) grading system, with DR defined as typical lesions ...
American Diabetes Association
Josephine H. Li, James A. Perry, Kathleen A. Jablonski, Shylaja Srinivasan, Ling Chen, Jennifer N. Todd, Maegan Harden, Josep M. Mercader, Qing Pan, Adem Y. Dawed, Sook Wah Yee, Ewan R. Pearson, Kathleen M. Giacomini, Ayush Giri, Adriana M. Hung, Shujie Xiao, L. Keoki Williams, Paul W. Franks, Robert L. Hanson, Steven E. Kahn, William C. Knowler, Toni I. Pollin, José C. Florez, George A. Bray, Kishore M. Gadde, Iris W. Culbert, Annie Chatellier, Jennifer Arceneaux, Amber Dragg, Catherine M. Champagne, Crystal Duncan, Barbara Eberhardt, Frank L. Greenway, Fonda G. Guillory, April A. Herbert, Michael L. Jeffirs, Betty M. Kennedy, Erma Levy, Monica Lockett, Jennifer C. Lovejoy, Laura H. Morris, Lee E. Melancon, Donna H. Ryan, Deborah A. Sanford, Kenneth G. C. Smith, Lisa L. Smith, Julia A. St. Amant, Richard T. Tulley, Paula C. Vicknair, Donald S. Williamson, J. J. Zachwieja, Kenneth S. Polonsky, Janet Tobian, David A. Ehrmann, Margaret J. Matulik, Karla A. Temple, Bart Clark, Kirsten Czech, Catherine DeSandre, Brittnie Dotson, Ruthanne Hilbrich, Wylie McNabb, Michael T. Quinn, Ann R. Semenske, F. José, Kevin Furlong, Barry J. Goldstein, Pamela G. Watson, Kellie A. Smith, Jewel Mendoza, Wendi Wildman, Marsha Simmons, Genine Jensen, Renee Liberoni, John Spandorfer, Constance Pepe, Richard P. Donahue, Ronald Goldberg, Ronald J. Prineas, Patricia M. Rowe, Anna Giannella, Jeanette Calles, Juliet Sanguily, Paul Cassanova-Romero, Sumaya Castillo-Florez, Hermes Flórez, Rajesh Garg, Lascelles Kirby, Olga Lara, Carmen Larreal, Valerie McLymont, Jadell Mendez, Arlette C. Perry, Patrice G. Saab, Bertha Veciana, Steven M. Haffner, Helen P. Hazuda, Maria G. Montez, Juan Isaac, Kathy Hattaway, Carlos Lorenzo, Arlene Martinez, Monica Salazar, Tatiana Walker, Richard F. Hamman, Dana Dabelea, Patricia V. Nash, Sheila C. Steinke, Lisa Testaverde, Jennifer Truong, Denise Anderson, Larry B. Ballonoff, Alexis Bouffard, Rebecca S. Boxer, Brian C. Bucca, B. Ned Calonge, Lynne Delve, Martha Farago, James O. Hill, Shelley R. Hoyer, Tonya Jenkins, Bonnie T. Jortberg, Dione Lenz, Marsha Miller, Thomas Nilan, Leigh Perreault, David W. Price, Judith G. Regensteiner, Emily B. Schroeder, Helen Seagle, Carissa M. Smith, Brent VanDorsten, Edward S. Horton, Medha Munshi, Kathleen E. Lawton, Catherine S. Poirier, Kati Swift, Sharon D. Jackson, Ronald A. Arky, Marybeth Bryant, Jacqueline P. Burke, Enrique Caballero, Karen M. Callaphan, Barbara Fargnoli, Therese Franklin, Om P Ganda, Ashley Guidi, Mathew Guido, Alan M. Jacobsen, Lyn M. Kula, Margaret Kocal, Lori Lambert, Kathleen E. Lawton, Sarah Ledbury, Maureen A. Malloy, Roeland J.W. Middelbeek, Maryanne Nicosia, Cathryn F. Oldmixon, Jocelyn Pan, Marizel Quitingon, Riley Rainville, Stacy Rubtchinsky, Ellen W. Seely, Jessica Sansoucy, Dana Schweizer, Donald C. Simonson, Fannie Smith, Caren G. Solomon, Jeanne Spellman, James H. Warram, Steven E. Kahn, Brenda K. Montgomery, Basma Fattaleh, Celeste Colegrove, Wilfred Y. Fujimoto, Robert H. Knopp, Edward W. Lipkin, Michelle Marr, Ivy Morgan-Taggart, Anne Murillo, Kayla O’Neal, Dace Trence, Lonnese Taylor, April Thomas, Elaine C. Tsai, Abbas E. Kitabchi, Samuel Dagogo‐Jack, Mary E. Murphy, Laura Taylor, Jennifer Dolgoff, Ethel Faye Hampton, William B. Applegate, Michael Bryer‐Ash, Debra Clark, Sandra L. Frieson, Uzoma N. Ibebuogu, Raed Imseis, Helen Lambeth, Lynne C. Lichtermann, Hooman Oktaei, Harriet Ricks, Lily M.K. Rutledge, Amy R. Sherman, Clara M. Smith, Judith E. Soberman, Beverly Williams-Cleaves, Avnisha Patel, Ebenezer Nyenwe, Ethel Faye Hampton, Boyd E. Metzger, Mark E. Molitch, Amisha Wallia, Mariana K. Johnson, Sarah VanderMolen, Daphne T. Adelman, Catherine Behrends, Michelle Cook, Marian L. Fitzgibbon, Mimi M. Giles, Monica Hartmuller, Cheryl K.H. Johnson, Diane Larsen, Anne Lowe, Megan Lyman, David D. McPherson, Samsam C. Penn, Thomas Pitts, Renee Reinhart, Susan Roston, Pamela A. Schinleber, David M. Nathan, Charles McKitrick, Heather Turgeon, Mary Larkin, Marielle Mugford, Nopporn Thangthaeng, Fernelle Leander, Kathy Abbott, Ellen J. Anderson, Laurie Bissett, Kristy Bondi, Enrico Cagliero, José C. Florez, Linda M. Delahanty, Valerie Goldman, Elaine Grassa, Lindsey Gurry, Kali D’Anna, Fernelle Leandre, Peter Lou, Alexandra Poulos, Elyse Raymond, Valerie Ripley, Christine Stevens, Beverly Tseng, Jerrold M. Olefsky, Elizabeth Barrett‐Connor, Sunder Mudaliar, Maria Rosario G. Araneta, Mary Lou Carrion-Petersen, Karen Vejvoda, Sarah Bassiouni, Madeline Beltran, Lauren N. Claravall, Jonalle M. Dowden, Steven V. Edelman, Pranav S. Garimella, Robert R. Henry, Javiva Horne, Marycie Lamkin, Simona Szerdi Janesch, Diana Leos, William H. Polonsky, Rosa Ruiz, Jean Louise M. Smith, Jennifer Torio-Hurley, F. Xavier Pi‐Sunyer, Blandine Laferrère, Jane E. Lee, Susan Hagamen, Kim Kelly-Dinham, David B. Allison, Nnenna Agharanya, Nancy J. Aronoff, Maria Baldo, Jill P. Crandall, Sandra T. Foo, José A. Luchsinger, Carmen Pal, Kathy Parkes, Mary Beth Pena, Julie Roman, Ellen S. Rooney, Gretchen E.H. Van Wye, Kristine A. Viscovich, Melvin Prince,
Genome-wide significant loci for metformin response in type 2 diabetes reported elsewhere have not been replicated in the Diabetes Prevention Program (DPP). To assess pharmacogenetic interactions in prediabetes, we conducted a genome-wide association study (GWAS) in the DPP. Cox proportional hazards models tested associations with diabetes incidence in the metformin (MET; n = 876) and placebo (PBO; n = 887) arms. Multiple linear regression assessed association with 1-year change in metformin-related quantitative ...
American Diabetes Association
Neil H. White, Qing Pan, William C. Knowler, Emily B. Schroeder, Dana Dabelea, Emily Y. Chew, Barbara Blodi, Ronald Goldberg, F. Xavier Pi‐Sunyer, Christine Darwin, Mathias Schlögl, David M. Nathan, Barry J. Goldstein, Kevin Furlong, Kellie A. Smith, Jewel Mendoza, Wendi Wildman, Marsha Simmons, Genine Jensen, Renee Liberoni, John Spandorfer, Constance Pepe, Richard P. Donahue, Ronald Goldberg, Ronald J. Prineas, Patricia M. Rowe, Anna Giannella, Jeanette Calles, Juliet Sanguily, Paul Cassanova-Romero, Sumaya Castillo-Florez, Hermes Flórez, Rajesh Garg, Lascelles Kirby, Olga Lara, Carmen Larreal, Valerie McLymont, Jadell Mendez, Arlette C. Perry, Patrice G. Saab, Bertha Veciana, Steven M. Haffner, Helen P. Hazuda, Maria G. Montez, Juan Isaac, Kathy Hattaway, Carlos Lorenzo, Arlene Martinez, Monica Salazar, Tatiana Walker, Richard F. Hamman, Dana Dabelea, Patricia V. Nash, Sheila C. Steinke, Lisa Testaverde, Jennifer Truong, Denise Anderson, Larry B. Ballonoff, Alexis Bouffard, Rebecca S. Boxer, Brian C. Bucca, B. Ned Calonge, Lynne Delve, Martha Farago, James O. Hill, Shelley R. Hoyer, Tonya Jenkins, Bonnie T. Jortberg, Dione Lenz, Marsha Miller, Thomas Nilan, Leigh Perreault, David W. Price, Judith G. Regensteiner, Emily B. Schroeder, Helen Seagle, Carissa M. Smith, Brent VanDorsten, Edward S. Horton, Medha Munshi, Kathleen E. Lawton, Catherine S. Poirier, Kati Swift, Sharon D. Jackson, Ronald A. Arky, Marybeth Bryant, Jacqueline P. Burke, Enrique Caballero, Karen M. Callaphan, Barbara Fargnoli, Therese Franklin, Om P Ganda, Ashley Guidi, Mathew Guido, Alan M. Jacobsen, Lyn M. Kula, Margaret Kocal, Lori Lambert, Kathleen E. Lawton, Sarah Ledbury, Maureen A. Malloy, Roeland J.W. Middelbeek, Maryanne Nicosia, Cathryn F. Oldmixon, Jocelyn Pan, Marizel Quitingon, Riley Rainville, Stacy Rubtchinsky, Ellen W. Seely, Jessica Sansoucy, Dana Schweizer, Donald C. Simonson, Fannie Smith, Caren G. Solomon, Jeanne Spellman, James H. Warram, Steven E. Kahn, Brenda K. Montgomery, Basma Fattaleh, Celeste Colegrove, Wilfred Y. Fujimoto, Robert H. Knopp, Edward W. Lipkin, Michelle Marr, Ivy Morgan-Taggart, Anne Murillo, Kayla O’Neal, Dace Trence, Lonnese Taylor, April Thomas, Elaine C. Tsai, Abbas E. Kitabchi, Samuel Dagogo‐Jack, Mary E. Murphy, Laura J. Taylor, Jennifer Dolgoff, Ethel Faye Hampton, William B. Applegate, Michael Bryer‐Ash, Debra Clark, Sandra L. Frieson, Uzoma N. Ibebuogu, Raed Imseis, Helen Lambeth, Lynne C. Lichtermann, Hooman Oktaei, Harriet Ricks, Lily M.K. Rutledge, Amy R. Sherman, Clara M. Smith, Judith E. Soberman, Beverly Williamsleaves, Avnisha Patel, Ebenezer Nyenwe, Boyd E. Metzger, Mark E. Molitch, Amisha Wallia, Mariana K. Johnson, Sarah VanderMolen, Daphne T. Adelman, Catherine Behrends, Michelle Cook, Marian L. Fitzgibbon, Mimi M. Giles, Monica Hartmuller, Cheryl K.H. Johnson, Diane Larsen, Anne Lowe, Megan Lyman, David D. McPherson, Samsam C. Penn, Thomas Pitts, Renee Reinhart, Susan Roston, Pamela A. Schinleber, David M. Nathan, Charles McKitrick, Heather Turgeon, Mary Larkin, Marielle Mugford, Nopporn Thangthaeng, Fernelle Leander, Kathy Abbott, Ellen Anderson, Laurie Bissett, Kristy Bondi, Enrico Cagliero, José C. Florez, Linda M. Delahanty, Valerie Goldman, Elaine Grassa, Lindsey Gurry, Kali D’Anna, Fernelle Leandre, Peter Lou, Alexandra Poulos, Elyse Raymond, Valerie Ripley, Christine Stevens, Beverly Tseng, Jerrold M. Olefsky, Elizabeth Barrettonnor, Sunder Mudaliar, Maria Rosario G. Araneta, Mary Lou Carrion-Petersen, Karen Vejvoda, Sarah Bassiouni, Madeline Beltran, Lauren N. Claravall, Jonalle M. Dowden, Steven V. Edelman, Pranav S. Garimella, Robert R. Henry, Javiva Horne, Marycie Lamkin, Simona Szerdi Janesch, Diana Leos, William H. Polonsky, Rosa Ruiz, Jean Louise M. Smith, Jennifer Torio-Hurley, F. Xavier Pi‐Sunyer, Blandine Laferrère, Jane E. Lee, Susan Hagamen, Kim Kelly-Dinham, David B. Allison, Nnenna Agharanya, Nancy J. Aronoff, Maria Baldo, Jill P. Crandall, Sandra T. Foo, José A. Luchsinger, Carmen Pal, Kathy Parkes, Mary Beth Pena, Julie Roman, Ellen S. Rooney, Gretchen E.H. VanWye, Kristine A. Viscovich, Melvin Prince, David G. Marrero, Kieren J. Mather, Mary de Groot, Susie M. Kelly, Marcia A. Jackson, Gina McAtee, Paula Putenney, Ronald T. Ackermann, Carolyn M. Cantrell, Yolanda F. Dotson, Edwin S. Fineberg, Megan Fultz, John Guare, Angela Hadden, James M. Ignaut, Marion S. Kirkman, Erin O’Kelly Phillips, Kisha L. Pinner, Beverly D. Porter, Paris Roach, Nancy Rowland, Madelyn L. Wheeler, Robert E. Ratner, Vanita R. Aroda, Michelle Magee, Gretchen Youssef, Sue Shapiro, Natalie Andon, Catherine Bavido-Arrage, Geraldine Boggs, Marjorie Bronsord, Ernestine Brown, Holly Love Burkott, Wayman W. Cheatham, Susan Cola, Cindy Evans, Peggy Gibbs, Tracy Kellum, Lilia Leon, Milvia Lagarda, Claresa Levatan, Milajurine Lindsay, Asha K. Nair, Jean Park, Maureen Passaro, Angela Silverman, Gabriel I. Uwaifo, Debra Wells-Thayer, Renee Wiggins, Mohammed Saad, Karol E. Watson, Maria Budget, Sujata Jinagouda, Medhat Botrous, Anthony Sosa,
OBJECTIVE To determine whether interventions that slow or prevent the development of type 2 diabetes in those at risk reduce the subsequent prevalence of diabetic retinopathy. RESEARCH DESIGN AND METHODS The Diabetes Prevention Program (DPP) randomized subjects at risk for developing type 2 diabetes because of overweight/obesity and dysglycemia to metformin (MET), intensive lifestyle intervention (ILS), or placebo (PLB) to assess the prevention of diabetes. During the DPP and DPP Outcome Study (DPPOS), ...
American Diabetes Association
Ellie Goulding, Lucy C. Ward, Faye E. Allan, Drew Dittman, J. Enrique Salcedo-Sora, Andrew J. Carnell,
Abstract A growing number of hydrolase enzymes show promiscuous acyltransferase activity, even under aqueous conditions. Here we report, for the first time, the ability of Pyrobaculum calidifontis VA1 esterase (PestE) to catalyse the formation of a wide range of amides in buffer, where the acyl donor forms a significant structural component in the amide product. The reactions occur under mild conditions and can achieve conversions up to 97 % in 6 h for formation of N‐benzylfuranamide as the model reaction. ...
Tópico(s): Analytical Chemistry and Chromatography
2024 - Wiley | Angewandte Chemie
Ellie Goulding, Lucy C. Ward, Faye E. Allan, Drew Dittman, J. Enrique Salcedo-Sora, Andrew J. Carnell,
A growing number of hydrolase enzymes show promiscuous acyltransferase activity, even under aqueous conditions. Here we report, for the first time, the ability of Pyrobaculum calidifontis VA1 esterase (PestE) to catalyse the formation of a wide range of amides in buffer, where the acyl donor forms a significant structural component in the amide product. The reactions occur under mild conditions and can achieve conversions up to 97 % in 6 h for formation of N-benzylfuranamide as the model reaction. ...
Tópico(s): HIV/AIDS drug development and treatment
2024 - Wiley | Angewandte Chemie International Edition
Lucy C. Ward, Hannah V. McCue, Daniel J. Rigden, Neil M. Kershaw, Chloe Ashbrook, Harry Hatton, Ellie Goulding, James R. Johnson, Andrew J. Carnell,
Abstract Carboxyl methyltransferase (CMT) enzymes catalyse the biomethylation of carboxylic acids under aqueous conditions and have potential for use in synthetic enzyme cascades. Herein we report that the enzyme FtpM from Aspergillus fumigatus can methylate a broad range of aromatic mono‐ and dicarboxylic acids in good to excellent conversions. The enzyme shows high regioselectivity on its natural substrate fumaryl‐ l ‐tyrosine, trans , trans ‐muconic acid and a number of the dicarboxylic acids tested. ...
Tópico(s): Enzyme Catalysis and Immobilization
2022 - Wiley | Angewandte Chemie
Josephine H. Li, Laura Brenner, Varinderpal Kaur, Katherine Figueroa, Philip Schroeder, Alicia Huerta-Chagoya, Ji Chen, Cassandra N. Spracklen, Gaëlle Marenne, Arushi Varshney, Laura J. Corbin, Jian’an Luan, Sara M. Willems, Ying Wu, Xiaoshuai Zhang, Momoko Horikoshi, Thibaud Boutin, Reedik Mägi, Johannes Waage, Ruifang Li‐Gao, Kei Hang Katie Chan, Jie Yao, Mila Desi Anasanti, Audrey Y. Chu, Annique Claringbould, Jani Heikkinen, Jae‐Young Hong, Jouke‐Jan Hottenga, Shaofeng Huo, Marika A. Kaakinen, Tin Louie, Winfried März, Hortensia Moreno-Macías, Anne Ndungu, Sarah C. Nelson, Ilja M. Nolte, Kari E. North, Chelsea K. Raulerson, Debashree Ray, Rebecca Rohde, Denis Rybin, Claudia Schurmann, Xueling Sim, Loz Southam, Isobel D. Stewart, Carol A. Wang, Yujie Wang, Peitao Wu, Weihua Zhang, Tarunveer S. Ahluwalia, Emil V. R. Appel, Lawrence F. Bielak, Jennifer A. Brody, Noël P. Burtt, Claudia P. Cabrera, Brian E. Cade, Jin Fang Chai, Xiaoran Chai, Li-Ching Chang, Chien-Hsiun Chen, Brian H. Chen, Kumaraswamy Naidu Chitrala, Yen‐Feng Chiu, Hugoline G. de Haan, Graciela E. Delgado, Ayşe Demirkan, Qing Duan, Jorgen Engmann, Segun Fatumo, Javier Gayán, Franco Giulianini, Jung Ho Gong, Stefan Gustafsson, Yang Hai, Fernando Pires Hartwig, Jing He, Yoriko Heianza, Tao Huang, Alicia Huerta-Chagoya, Mi Yeong Hwang, Richard A. Jensen, Takahisa Kawaguchi, Katherine A. Kentistou, Young Jin Kim, Marcus E. Kleber, Ishminder K. Kooner, Shuiqing Lai, Leslie A. Lange, Carl D. Langefeld, Marie Lauzon, Man Li, Symen Ligthart, Jun Liu, Marie Loh, Jirong Long, Valeriya Lyssenko, Massimo Mangino, Carola Marzi, May E. Montasser, Abhishek Nag, Masahiro Nakatochi, Damia Noce, Raymond Noordam, Giorgio Pistis, Michael Preuß, Laura M. Raffield, Laura J. Rasmussen‐Torvik, Stephen S. Rich, Neil R. Robertson, Rico Rueedi, Kathleen A. Ryan, Serena Sanna, Richa Saxena, Katharina E. Schraut, Bengt Sennblad, Kazuya Setoh, Albert V. Smith, Lorraine Southam, Thomas Sparsø, Rona J. Strawbridge, Fumihiko Takeuchi, Jingyi Tan, Stella Trompet, Erik B. van den Akker, Peter J. van der Most, Niek Verweij, Mandy Vogel, Heming Wang, Chaolong Wang, Nan Wang, Helen R. Warren, Wanqing Wen, Tom Wilsgaard, Andrew L. Wong, Andrew R. Wood, Tian Xie, Mohammad Hadi Zafarmand, Jinghua Zhao, Wei Zhao, Najaf Amin, Zorayr Arzumanyan, Arne Astrup, Stephan J. L. Bakker, Damiano Baldassarre, Marian Beekman, Richard N. Bergman, Alain G. Bertoni, Matthias Blüher, Lori L. Bonnycastle, Stefan R. Bornstein, Donald W. Bowden, Qiuyin Cai, A.M. Campbell, Harry Campbell, Yi‐Cheng Chang, Eco J. C. de Geus, Abbas Dehghan, Shufa Du, Guðný Eiríksdóttir, Aliki Eleni Farmaki, Mattias Frånberg, Christian Fuchsberger, Yu‐Tang Gao, Anette P. Gjesing, Anuj Goel, Sohee Han, Catharina A. Hartman, Christian Herder, Andrew A. Hicks, Chang‐Hsun Hsieh, Willa A. Hsueh, Sahoko Ichihara, Michiya Igase, M. Arfan Ikram, W. Craig Johnson, Marit E. Jørgensen, Peter K. Joshi, Rita R. Kalyani, Fouad Kandeel, Tomohiro Katsuya, Chiea Chuen Khor, Wieland Kieß, Ivana Kolčić, Teemu Kuulasmaa, Johanna Kuusisto, Kristi Läll, Kelvin Lam, Debbie A. Lawlor, Sang Lee, Rozenn N. Lemaître, Honglan Li, Shih-Yi Lin, Jaana Lindström, Allan Linneberg, Jianjun Liu, Carlos Lorenzo, Tatsuaki Matsubara, Fumihiko Matsuda, Geltrude Mingrone, Simon P. Mooijaart, Sanghoon Moon, Toru Nabika, Girish N. Nadkarni, Jerry L. Nadler, Mari Nelis, Matt J. Neville, Jill M. Norris, Yasumasa Ohyagi, Annette Peters, Patricia A. Peyser, Ozren Polašek, Qibin Qi, Dennis Raven, Dermot F. Reilly, Alex P. Reiner, Fernando Rivideneira, Kathryn Roll, Igor Rudan, Charumathi Sabanayagam, Kevin Sandow, Naveed Sattar, Annette Schürmann, Jinxiu Shi, Heather M. Stringham, Kent D. Taylor, Tanya M. Teslovich, Betina H. Thuesen, Paul R. H. J. Timmers, Elena Tremoli, Michael Y. Tsai, André G. Uitterlinden, Rob M. van Dam, Diana van Heemst, Astrid van Hylckama Vlieg, Jana V. van Vliet‐Ostaptchouk, Jagadish Vangipurapu, Henrik Vestergaard, Tao Wang, Ko Willems van Dijk, Tatijana Zemunik, Gonçalo R. Abecasis, Linda S. Adair, Carlos A. Aguilar‐Salinas, Marta E. Alarcón‐Riquelme, Ping An, M. Larissa Avilés‐Santa, Diane M. Becker, Lawrence J. Beilin, Sven Bergmann, Hans Bisgaard, Corri Black, Michael Boehnke, Eric Boerwinkle, Bernhard Böhm, Klaus Bønnelykke, D.I. Boomsma, Erwin P. Böttinger, Thomas A. Buchanan, Mickaël Canouil, Mark J. Caulfield, John C. Chambers, Daniel I. Chasman, Yii‐Der Ida Chen, Ching‐Yu Cheng, Francis S. Collins, Adolfo Correa, Francesco Cucca, H. Janaka de Silva, George Dedoussis, Sölve Elmståhl, Michele K. Evans, Ele Ferrannini, Luigi Ferrucci, José C. Florez, Paul W. Franks, Timothy M Frayling, Philippe Froguel, Bruna Gigante, Mark O. Goodarzi, Penny Gordon‐Larsen, Harald Grallert, Niels Grarup, Sameline Grimsgaard, Leif Groop, Vilmundur Guðnason, Xiuqing Guo, Anders Hamsten, Torben Hansen, Caroline Hayward, Susan R. Heckbert, Bernardo Lessa Horta, Wei Huang, Erik Ingelsson, James S. Pankow, Marjo‐Riitta Järvelin, Jost B. Jonas,
Characterisation of genetic variation that influences the response to glucose-lowering medications is instrumental to precision medicine for treatment of type 2 diabetes. The Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans (SUGAR-MGH) examined the acute response to metformin and glipizide in order to identify new pharmacogenetic associations for the response to common glucose-lowering medications in individuals at risk of type 2 diabetes. One thousand participants ...
Springer Science+Business Media
Martin Dennis, Gillian Mead, John Forbes, Catriona Graham, Maree L. Hackett, Graeme J. Hankey, Allan House, Steff Lewis, Erik Lundström, Peter Sandercock, Karen Innes, Carol Williams, Jonathan Drever, Aileen McGrath, Ann Deary, Ruth Fraser, Rosemary Anderson, Pauli Walker, David Perry, Connor McGill, David L. Buchanan, Yvonne Chun, Lynn Dinsmore, Emma Maschauer, Amanda Barugh, Shadia Mikhail, Gordon W. Blair, Ingrid Hoeritzauer, Maggie Scott, Greig Fraser, Katherine E. Lawrence, Alison Shaw, Judith Williamson, David Burgess, Malcolm Macleod, Dan Morales, Frank Sullivan, Marian Brady, Ray French, Frederike van Wijck, Caroline Watkins, Fiona Proudfoot, Joanna Skwarski, Diane Mcgowan, Rachael E. Murphy, Seona Burgess, William F. Rutherford, Katrina McCormick, Ruaridh Buchan, Allan MacRaild, Ruth Paulton, Fazal Adnan, Pat Taylor, Ruwan Parakramawansha, Neil Hunter, Jack Perry, John Bamford, Dean Waugh, Emelda Veraque, Caroline Bedford, Mary Kambafwile, Luis Idrovo, Linetty Makawa, Paula Smalley, Marc Randall, Tharani Thirugnanachandran, Ahamad Hassan, Richard Vowden, Joanne Jackson, Ajay Bhalla, Anthony Rudd, Chi Kai Tam, Jonathan Birns, Charlotte Gibbs, Leonie Lee Carbon, E. Cattermole, Katherine Marks, Angela Cape, Lisa Hurley, Sagal Kullane, Nigel Smyth, Charlotte Eglinton, Jennifer G. Wilson, Elio Giallombardo, Angela Frith, Paul T. Reidy, Matthew Pitt, Lucy Sykes, Deborah Dellafera, Victoria Croome, Lauriane Kerwood, Mirea Hančević, Christina Narh, Carley Merritt, John P. Duffy, Duncan Cooke, Juliet Willson, Ali Ali, Aaizza Naqvi, Christine Kamara, Helen Bowler, Simon Bell, Tracy Jackson, Kirsty Harkness, Kathy Stocks, Suzanna Duty, Clare Doyle, Geoffrey P. Dunn, Keith Endean, Fiona Claydon, Emma Richards, Jo Howe, Ralf Lindert, Arshad Majid, Katy Dakin, Ahmad Maatouk, Luke Barron, Madana Meegada, Pratap Rana, Anand R. Nair, Christine Brighouse-Johnson, Jill Greig, Myint Kyu, Sanjeev Prasad, Matthew K. Robinson, Irfan Alam, Belinda McLean, Lindsay Greenhalgh, Zenab Ahmed, Christine Roffe, Susan V. Brammer, Carole Beardmore, K. Finney, Adrian Barry, Paul Hollinshead, Jeanette Grocott, Holly Maguire, Indira Natarajan, J Chembala, Ranjan Sanyal, Sue Lijko, Nenette Abano, Alda Remegoso, Phillip Ferdinand, Stephanie Stevens, Resti Varquez, Chelsea Causley, Adrian Butler, Philip Whitmore, C. Haskins Stephen, Racquel Carpio, Joanne Hiden, Girish Muddegowda, Hayley Denic, Jane Sword, Ross Curwen, Martin James, Paul N. Mudd, Fiona Hall, Julie Cageao, Samantha Keenan, Caroline Roughan, Hayley Kingwell, Anthony Hemsley, Christoph Lohan, Sue Davenport, A. Bowring, Tamika Chapter, M.A. Hough, W. David Strain, Karin Gupwell, Keniesha Miller, Anita Goff, Ellie Cusack, Shirley Todd, Rebecca Partridge, Georgiana Jennings, Kevin E. Thorpe, Jacquelyn Stephenson, Kelly Littlewood, Mark Barber, Fiona Brodie, Steven Marshall, Derek Esson, Irene Coburn, Caroline McInnes, Fiona Ross, Emma Bowie, Heather Barcroft, Victoria Withers, Laura Miller, Paul Willcoxson, Michelle Donninson, Richard J. Evans, Di Daniel, John Coyle, Michael Keeling, Peter Wanklyn, Mark T. Elliott, John Wightman, Elizabeth Iveson, Natasha Dyer, Anne-Marie Porteous, Monica Haritakis, Mandy Ward, Lucy Doughty, Lisa Carr, Mark O Neill, Cosmas Anazodo, Paul Wood, Poppy Cottrell, Cheryl Donne, Romina M. Rodríguez, Ruhail Mir, Jax Westmoreland, Judith A. Bell, Christopher Emms, Lorraine M. Wright, Pearl Clark Brown, Elizabeth Bamford, Andrew Stanners, Mike Carpenter, Prabal Datta, Richard Davey, Ann Needle, Marjorie Jane Eastwood, Fathima Zeena Razik, Imran Ghouri, Gavin Bateman, Judy Archer, Venkatesh Balasubramanian, Richard Bowers, Julie Ball, Louise Benton, Linda Jackson, Julie Ellam, Kate Norton, Paul Guyler, Terry Dowling, Sharon Tysoe, Paula Harman, Ashish Kundu, Ololade Omodunbi, Thayalini Loganathan, Stuart Chandler, Shanas Noor, Anwer Siddiqui, Amber Tahir, Swapna Kunhunny, Devesh Sinha, Martin Sheppard, Sindhu Rashmi, Elena France, Rajalakshmi Orath Prabakaran, Laura Wilson, Amiirah Ropun, Shyam Kelavkar, Kheng Xiong Ng, Lucy Kamuriwo, Sweni Shah, David Mangion, Camen Constantin, Luigi De Michele Hock, Anne Hardwick, Jayne Borley, Skarlet Markova, Kimberley Netherton, Tara Lawrence, Jo Fletcher, Rebecca Spencer, Helen Palmer, Claire Cullen, Dolores Hamill, Ramesh Durairaj, Mellor Zoe, Tanya Fluskey, Diane P. Wood, Alison Keeling, Victoria Hankin, Jennifer Peters, Daniela Shackcloth, Thant Hlaing, Rebecca Tangney, Jordan Ewing, Melanie Harrison, Sarah Stevenson, Victoria Sutton, Mohamed Soliman, Julia Hindle, Elizabeth Watson, Claire Hewitt, Jayne Borley, Susie Butler, Ibrahim Wahishi, Sarwat Arif, Amy Fields,
Results of small trials indicate that fluoxetine might improve functional outcomes after stroke. The FOCUS trial aimed to provide a precise estimate of these effects.FOCUS was a pragmatic, multicentre, parallel group, double-blind, randomised, placebo-controlled trial done at 103 hospitals in the UK. Patients were eligible if they were aged 18 years or older, had a clinical stroke diagnosis, were enrolled and randomly assigned between 2 days and 15 days after onset, and had focal neurological deficits. ...
Elsevier BV
Andrea M. Kriska, Bonny Rockette‐Wagner, Sharon L. Edelstein, George A. Bray, Linda M. Delahanty, Mary A. Hoskin, Edward S. Horton, Elizabeth M. Venditti, William C. Knowler, George A. Bray, Kishore M. Gadde, Iris W. Culbert, Jennifer Arceneaux, Annie Chatellier, Amber Dragg, Catherine M. Champagne, Crystal Duncan, Barbara Eberhardt, Frank L. Greenway, Fonda G. Guillory, April A. Herbert, Michael L. Jeffirs, Betty M. Kennedy, Erma Levy, Monica Lockett, Jennifer C. Lovejoy, Laura H. Morris, Lee E. Melancon, Donna H. Ryan, Deborah A. Sanford, Kenneth G. C. Smith, Lisa L. Smith, Julia A. St. Amant, Richard T. Tulley, Paula C. Vicknair, Donald Williamson, J. J. Zachwieja, Kenneth S. Polonsky, Janet Tobian, David A. Ehrmann, Margaret J. Matulik, Bart Clark, Kirsten Czech, Catherine DeSandre, Ruthanne Hilbrich, Wylie McNabb, Ann R. Semenske, F. José, Kevin Furlong, Barry J. Goldstein, Pamela G. Watson, Kellie A. Smith, Jewel Mendoza, Wendi Wildman, Renee Liberoni, John Spandorfer, Constance Pepe, Richard P. Donahue, Ronald Goldberg, Ronald J. Prineas, Jeanette Calles, Juliet Ojito, Patricia M. Rowe, Paul Cassanova-Romero, Sumaya Castillo-Florez, Hermes Flórez, Anna Giannella, Lascelles Kirby, Carmen Larreal, Olga Lara, Valerie McLymont, Jadell Mendez, Arlette C. Perry, Patrice G. Saab, Beth Veciana, Steven M. Haffner, Helen P. Hazuda, Maria G. Montez, Kathy Hattaway, Carlos Lorenzo, Arlene Martinez, Tatiana Walker, Dana Dabelea, Richard F. Hamman, Patricia V. Nash, Sheila C. Steinke, Lisa Testaverde, Denise Anderson, Larry B. Ballonoff, Alexis Bouffard, Brian C. Bucca, B. Ned Calonge, Lynne Delve, Martha Farago, James O. Hill, Shelley R. Hoyer, Tonya Jenkins, Bonnie T. Jortberg, Dione Lenz, Marsha Miller, Leigh Perreault, David W. Price, Judith G. Regensteiner, Helen Seagle, Carissa M. Smith, Brent VanDorsten, Edward S. Horton, Kathleen E. Lawton, Catherine S. Poirier, Kati Swift, Ronald A. Arky, Marybeth Bryant, Jacqueline P. Burke, Enrique Caballero, Karen M. Callaphan, Barbara Fargnoli, Therese Franklin, Om P Ganda, Ashley Guidi, Mathew Guido, Sharon D. Jackson, Alan M. Jacobsen, Lori Lambert, Sarah Ledbury, Margaret Kocal, Lyn M. Kula, Maureen A. Malloy, Maryanne Nicosia, Cathryn F. Oldmixon, Jocelyn Pan, Marizel Quitingon, Stacy Rubtchinsky, Jessica Sansoucy, Dana Schweizer, Ellen W. Seely, Donald C. Simonson, Fannie Smith, Caren G. Solomon, Jeanne Spellman, James H. Warram, Steven E. Kahn, Brenda K. Montgomery, Wilfred Y. Fujimoto, Robert H. Knopp, Edward W. Lipkin, Michelle Marr, Ivy Morgan-Taggart, Anne Murillo, Dace Trence, Lonnese Taylor, April Thomas, Elaine C. Tsai, Samuel Dagogo‐Jack, Abbas E. Kitabchi, Mary E. Murphy, Laura Taylor, Jennifer Dolgoff, William B. Applegate, Michael Bryer‐Ash, Debra Clark, Sandra L. Frieson, Uzoma N. Ibebuogu, Raed Imseis, Helen Lambeth, Lynne C. Lichtermann, Hooman Oktaei, Harriet Ricks, Lily K. Rutledge, Amy R. Sherman, Clara M. Smith, Judith E. Soberman, Beverly Williams-Cleaves, Boyd E. Metzger, Mark E. Molitch, Mariana K. Johnson, Daphne T. Adelman, Catherine Behrends, Michelle Cook, Marian L. Fitzgibbon, Mimi M. Giles, Deloris Heard, Cheryl H. Johnson, Diane Larsen, Anne Lowe, Megan Lyman, David D. McPherson, Samsam C. Penn, Thomas Pitts, Renee Reinhart, Susan Roston, Pamela A. Schinleber, David M. Nathan, Charles McKitrick, Heather Turgeon, Mary Larkin, Kathy Abbott, Ellen J. Anderson, Laurie Bissett, Kristy Bondi, Enrico Cagliero, José C. Florez, Kali D’Anna, Linda M. Delahanty, Valerie Goldman, Peter Lou, Alexandra Poulos, Elyse Raymond, Christine Stevens, Beverly Tseng, Jerrold M. Olefsky, Elizabeth Barrett‐Connor, Mary Lou Carrion-Petersen, Madeline Beltran, Lauren N. Claravall, Jonalle M. Dowden, Steven V. Edelman, Robert R. Henry, Javiva Horne, Marycie Lamkin, Simona Szerdi Janesch, Diana Leos, Sunder Mudaliar, William H. Polonsky, Jean Louise M. Smith, Jennifer Torio-Hurley, Karen Vejvoda, F. Xavier Pi‐Sunyer, Jane E. Lee, David B. Allison, Nnenna Agharanya, Nancy J. Aronoff, Maria Baldo, Jill P. Crandall, Sandra T. Foo, Susan Hagamen, José A. Luchsinger, Carmen Pal, Kathy Parkes, Mary Beth Pena, Ellen S. Rooney, Gretchen H. VanWye, Kristine A. Viscovich, David G. Marrero, Kieren J. Mather, Melvin Prince, Susie M. Kelly, Marcia A. Jackson, Gina McAtee, Paula Putenney, Ronald T. Ackermann, Carolyn M. Cantrell, Yolanda F. Dotson, Edwin S. Fineberg, Megan Fultz, John Guare, Angela Hadden, James M. Ignaut, Marion S. Kirkman, Erin O’Kelly Phillips, Beverly D. Porter, Paris Roach, Nancy Rowland, Madelyn L. Wheeler, Vanita R. Aroda, Robert E. Ratner, Gretchen Youssef, Sue Shapiro, Catherine Bavido-Arrage, Geraldine Boggs, Marjorie Bronsord, Ernestine Brown, Wayman W. Cheatham, Susan Cola, Cindy Evans, Peggy Gibbs, Tracy Kellum, Renee Wiggins, Milvia Lagarda, Lilia Leon, Claresa Levatan, Milajurine Lindsay, Asha K. Nair, Maureen Passaro, Angela Silverman, Gabriel I. Uwaifo, Debra Wells-Thayer, Mohammed Saad, Karol E. Watson, Maria Budget, Sujata Jinagouda, Medhat Botrous, Khan Akbar, Claudia Conzues, Perpetua Magpuri, Kathy Ngo, Amer Rassam,
Across the Diabetes Prevention Program (DPP) follow-up, cumulative diabetes incidence remained lower in the lifestyle compared with the placebo and metformin randomized groups and could not be explained by weight. Collection of self-reported physical activity (PA) (yearly) with cross-sectional objective PA (in follow-up) allowed for examination of PA and its long-term impact on diabetes prevention.Yearly self-reported PA and diabetes assessment and oral glucose tolerance test results (fasting glucose ...
American Diabetes Association
Tony Whitehouse, Md. Anower Hossain, Gavin D. Perkins, Anthony Gordon, Julian Bion, Duncan Young, Daniel F. McAuley, Mervyn Singer, Janet M. Lord, Simon Gates, Tonny Veenith, Niall MacCallum, Joyce Yeung, Richard Innes, Ingeborg Welters, Nafisa Boota, Emma Skilton, Belinder Ghuman, Maddy Hill, Scott Regan, Dipesh Mistry, Ranjit Lall, Tonny Veenith, Jaimin Patel, Nick Murphy, Mansoor N. Bangash, Tomasz Torliński, Nick P. Talbot, Catherine Snelson, Dhruv Parekh, Amisha Desai, Mary Kotada, Yin May Chin, Sophie Holden, Aoife Neal, Maximina Ventura, Martin Pope, Samantha Harkett, Christopher McGhee, Emma Fellows, Amy Bamford, Ronald Carrera, Karen Ellis, Elaine Spruce, Liesl Despy, Stephanie Porter, Colin Bergin, Stephanie Gouny, Hazel Smith, Tracy Mason, Natalie Dooley, Amy Clark, Joyce Yeung, Jo Gresty, Teresa Melody, Ellie Reeves, Rachel Smith, Julia Sampson, ACCP Team BHH Critical Care Unit, Chris Nutt, James P. McNamee, Daniel F. McAuley, Anen Boyle, Loren McGinley, Chris Wright, Kate A. Ward, Lauren Macartney, Justine Mccann, Brian Johnston, Janette Mills, Leona Bannon, Aisling O’Neill, Stephanie Finn, Anthony Gordon, David Antcliffe, Stephen J. Brett, Dorota Banach, Leilani Cabreros, Laura Curran, Sonia Sousa Arias, Roceld Rojo, Ziortza Fernández de Pinedo Artaraz, Phoebe Coghlan, Maie Templeton, A. Elhaddad, Zohonon Sabine Loko, Gareth J. Barker, Niall MacCallum, David Brealey, Mervyn Singer, Kristian Warnes, Nina Bason, Dorota Filipowicz, Georgia Bercades, Ingrid Hass, Jung Hee Ryu, Deborah Smyth, Dorothy Ilano, Daniel Harvey, Louise Conner, Lucy Ryan, Cecilia Peters, Megan Meredith, Megan K. McAulay, Zoe Whitman, Lucy Morris, C Woodford, Sally Hodgkinson, Sonya Finucane, Luigi Camporota, Manu Shankar‐Hari, Marlies Ostermann, Aneta Bociek, Rosario Lim, Neus GrauNovellas, Natalie Palmer, Angela Cape, Anea Kelly, Gill Arbane, Sarah Campos, Michael J. Singh, Jinny Yoo, Richard Innes, Fiona C. Dempsey, Patricia Doble, Rebecca Purnell, Moira Tait, J. Hutter, Corinne Pawley, Joy Rowe, Catherine Wane, Richard Burgess, Ashly Thomas, Pulak Paul, Brenda White, Wayne Lovegrove, Mandy Gill, Lynne Wade, Tracy Brear, Vishal Dhokia, Debbie Jackson, Sarah Shelton, Jill Kirk, Anew Boulton, Alistair Roy, Anthony Rostron, Zeynep Elcioglu, Lindsey Woods, Sarah Cornell, Rebecca Betts, Jill Holden, Stephen Laybourne, Kimberley Rogerson, Jeremy Bewley, Rebekah Johnson, Anna Chillingworth, Bethany Gumbrill, Hilary Galvin, Kim Wright, Georgia Efford, Kathleen Corcoran, Libby Cole, Katie Sweet, Denise Webster, Lisa Grimmer, Gemma Paris, Chloe Searles, Zoe Garland, Charly Gibson, Melanie Hutchings, Fiona Walters, Sinéad Kelly, Lorraine Scaife, Kelly Littlewood, James Leavy, Shirley Todd, Elizabeth Gordón, Sadie Heddon, Victor Mariano, Karin Gupwell, Rebecca Appelboam, Samantha Keenan, Cassie Brady, Ian Mew, Duncan Chambler, Sarah Williams, Pauline Ashcroft, Patricia Williams, James Rees, Sophie Wiseman, Sarah Horton, Mark Shortland, Stephanie Dukes, Andrew S. Ball, Michael Z. Spivey, Jennie Stephens, Sarah Bean, Karen Burt, Rachel Chapman, Carol Richards, Lorraine Moore, Linda Allsop, Amber Wynn, Louise Latty, Sam Waddy, Kayleigh Spencer, Bethan Stowe, Georgina Cox, Helen McMillan, Liana Lankester, Colin Wells, Rosalyn Squire, Mike Marner, Robert J. Jackson, Nikitas Nikitas, Stuart Dickson, Henrik Reschreiter, J. Bromilow, James Keegan, Chris Loew, Ken Power, Spike Briggs, Julie Camsooksai, Sarah Patch, Sarah M. Jenkins, Sharon Power, Elizabeth Woodward, David Pogson, Zoe Daly, Steve Rose, Aimi Collins, A.L. Phelps, Helen Claridge, Christine Minnis, Sarah K. Inglis, Lutece Brimfield, Charlotte Wong, Ingeborg Welters, Karen Williams, Victoria Waugh, Julie Patrick-Heselton, Emily Johnson, David M. Shaw, Brian Johnston, Maryam Crews, Alicia Waite, Vinoth Sankar, Jonathan R. Walker, Peter Turton, Richard Wenstone, Jaime Fernandez Roman, Alison Hall, Maria Lopez Martinez, David Hamilton, David Coey, Philip Shelley, Martin Goulding, K. L. Kavanagh, Ann Marron, Hannah Allsop, Philip Hopkins, John Smith, Harriet Noble, Evita Pappa, Clare Finney, Sinead Heyler, Emma Clarey, Maeve Cockrell, Maria Depante, Kevin O’Reilly, Christopher C. M. Waterhouse, Vicky Chu, Joanne Gordon, Greg Marchant, Stuart Chandler, Senait Haile, Joanna Flanagan, Gaynor Notcheva, Dom Jimenez, Dilbagh Gill, Sunil Jamadarkhana, Sunita Gohil, Sura Dabbagh, Katy-Jane Chick, Carina Cruz, Vikram Anumakonda, Vanessa Moore, L. K. Pulver, Sharon Westwood, Jacqueline Smith, Karen Reid, R Gidda, Elena Anastasescu, Karim M. Salem, Mohamed Mooradun, Michael Reay,
Importance Patients with septic shock undergo adrenergic stress, which affects cardiac, immune, inflammatory, and metabolic pathways. β-Blockade may attenuate the adverse effects of catecholamine exposure and has been associated with reduced mortality. Objectives To assess the efficacy and safety of landiolol in patients with tachycardia and established septic shock requiring prolonged (>24 hours) vasopressor support. Design, Setting, and Participants An open-label, multicenter, randomized ...
American Medical Association
Christine G. Lee, Adam Ciarleglio, Sharon L. Edelstein, Jill P. Crandall, Dana Dabelea, Ronald Goldberg, Steven E. Kahn, William C. Knowler, T. Maxwell, Neil H. White, William H. Herman, George A. Bray, Kishore M. Gadde, Iris W. Culbert, Jennifer Arceneaux, Annie Chatellier, Amber Dragg, Catherine M. Champagne, Crystal Duncan, Barbara Eberhardt, Frank L. Greenway, Fonda G. Guillory, April A. Herbert, Michael L. Jeffirs, Betty M. Kennedy, Erma Levy, Monica Lockett, Jennifer C. Lovejoy, Laura H. Morris, Lee E. Melancon, Donna H. Ryan, Deborah A. Sanford, Kenneth G. C. Smith, Lisa L. Smith, Julia A. St. Amant, Richard T. Tulley, Paula C. Vicknair, Donald Williamson, J. J. Zachwieja, Kenneth S. Polonsky, Janet Tobian, David A. Ehrmann, Margaret J. Matulik, Karla A. Temple, Bart Clark, Kirsten Czech, Catherine DeSandre, Brittnie Dotson, Ruthanne Hilbrich, Wylie McNabb, Ann R. Semenske, C. Thomas, F. José, Kevin Furlong, Barry J. Goldstein, Pamela G. Watson, Kellie A. Smith, Jewel Mendoza, Marsha Simmons, Wendi Wildman, Renee Liberoni, John Spandorfer, Constance Pepe, Richard P. Donahue, Ronald Goldberg, Ronald J. Prineas, Jeanette Calles, Anna Giannella, Patricia M. Rowe, Juliet Sanguily, Paul Cassanova-Romero, Sumaya Castillo-Florez, Hermes Flórez, Rajesh Garg, Lascelles Kirby, Olga Lara, Carmen Larreal, Valerie McLymont, Jadell Mendez, Arlette C. Perry, Patrice G. Saab, Bertha Veciana, Steven M. Haffner, Helen P. Hazuda, Maria G. Montez, Kathy Hattaway, Juan Isaac, Carlos Lorenzo, Arlene Martinez, Monica Salazar, Tatiana Walker, Dana Dabelea, Richard F. Hamman, Patricia V. Nash, Sheila C. Steinke, Lisa Testaverde, Jennifer Truong, Denise Anderson, Larry B. Ballonoff, Alexis Bouffard, Brian C. Bucca, B. Ned Calonge, Lynne Delve, Martha Farago, James O. Hill, Shelley R. Hoyer, Tonya Jenkins, Bonnie T. Jortberg, Dione Lenz, Marsha Miller, Thomas Nilan, Leigh Perreault, David W. Price, Judith G. Regensteiner, Emily B. Schroeder, Helen Seagle, Carissa M. Smith, Brent VanDorsten, Edward S. Horton, Medha Munshi, Kathleen E. Lawton, Sharon D. Jackson, Catherine S. Poirier, Kati Swift, Ronald A. Arky, Marybeth Bryant, Jacqueline P. Burke, Enrique Caballero, Karen M. Callaphan, Barbara Fargnoli, Therese Franklin, Om P Ganda, Ashley Guidi, Mathew Guido, Alan M. Jacobsen, Lyn M. Kula, Margaret Kocal, Lori Lambert, Sarah Ledbury, Maureen A. Malloy, Roeland J.W. Middelbeek, Maryanne Nicosia, Cathryn F. Oldmixon, Jocelyn Pan, Marizel Quitingon, Riley Rainville, Stacy Rubtchinsky, Ellen W. Seely, Jessica Sansoucy, Dana Schweizer, Donald C. Simonson, Fannie Smith, Caren G. Solomon, Jeanne Spellman, James H. Warram, Steven E. Kahn, Brenda K. Montgomery, Basma Fattaleh, Celeste Colegrove, Wilfred Y. Fujimoto, Robert H. Knopp, Edward W. Lipkin, Michelle Marr, Ivy Morgan-Taggart, Anne Murillo, Kayla O’Neal, Dace Trence, Lonnese Taylor, April Thomas, Elaine C. Tsai, Samuel Dagogo‐Jack, Abbas E. Kitabchi, Mary E. Murphy, Laura Taylor, Jennifer Dolgoff, William B. Applegate, Michael Bryer‐Ash, Debra Clark, Sandra L. Frieson, Uzoma N. Ibebuogu, Raed Imseis, Helen Lambeth, Lynne C. Lichtermann, Hooman Oktaei, Harriet Ricks, Lily M.K. Rutledge, Amy R. Sherman, Clara M. Smith, Judith E. Soberman, Beverly Williams-Cleaves, Avnisha Patel, Ebenezer Nyenwe, Ethel Faye Hampton, Boyd E. Metzger, Mark E. Molitch, Amisha Wallia, Mariana K. Johnson, Daphne T. Adelman, Catherine Behrends, Michelle Cook, Marian L. Fitzgibbon, Mimi M. Giles, Deloris Heard, Cheryl K.H. Johnson, Diane Larsen, Anne Lowe, Megan Lyman, David D. McPherson, Samsam C. Penn, Thomas Pitts, Renee Reinhart, Susan Roston, Pamela A. Schinleber, Matthew J. O’Brien, Monica Hartmuller, David M. Nathan, Charles McKitrick, Heather Turgeon, Mary Larkin, Marielle Mugford, Kathy Abbott, Ellen J. Anderson, Laurie Bissett, Kristy Bondi, Enrico Cagliero, José C. Florez, Linda M. Delahanty, Valerie Goldman, Elaine Grassa, Lindsery Gurry, Kali D’Anna, Fernelle Leandre, Peter Lou, Alexandra Poulos, Elyse Raymond, Valerie Ripley, Christine Stevens, Beverly Tseng, Kathy Chu, Nopporn Thangthaeng, Jerrold M. Olefsky, Elizabeth Barrett‐Connor, Sunder Mudaliar, Maria Rosario G. Araneta, Mary Lou Carrion-Petersen, Karen Vejvoda, Sarah Bassiouni, Madeline Beltran, Lauren N. Claravall, Jonalle M. Dowden, Steven V. Edelman, Pranav S. Garimella, Robert R. Henry, Javiva Horne, Marycie Lamkin, Simona Szerdi Janesch, Diana Leos, William H. Polonsky, Rosa Ruiz, Jean Louise M. Smith, Jennifer Torio-Hurley, F. Xavier Pi‐Sunyer, Blandine Laferrère, Jane E. Lee, Susan Hagamen, David B. Allison, Nnenna Agharanya, Nancy J. Aronoff, Maria Baldo, Jill P. Crandall, Sandra T. Foo, Kim Kelly-Dinham, José A. Luchsinger, Carmen Pal, Kathy Parkes, Mary Beth Pena, Ellen S. Rooney, Gretchen E.H. Van Wye, Kristine A. Viscovich, Mary de Groot, David G. Marrero, Kieren J. Mather, Melvin Prince, Susie M. Kelly, Marcia A. Jackson, Gina McAtee, Paula Putenney, Ronald T. Ackermann, Carolyn M. Cantrell, Yolanda F. Dotson, Edwin S. Fineberg, Megan Fultz, John Guare, Angela Hadden, James M. Ignaut, Marion S. Kirkman,
OBJECTIVE To assess associations between distal symmetric polyneuropathy (DSPN) and Diabetes Prevention Program (DPP) treatment groups, diabetes status or duration, and cumulative glycemic exposure approximately 21 years after DPP randomization. RESEARCH DESIGN AND METHODS In the DPP, 3,234 adults ≥25 years old at high risk for diabetes were randomized to an intensive lifestyle (ILS), metformin, or placebo intervention to prevent diabetes. After the DPP ended, 2,779 joined the Diabetes Prevention Program ...
American Diabetes Association
Marissa Shams‐White, Ashley H. Tjaden, Sharon L. Edelstein, Sarah Bassiouni, Lisa Kahle, Catherine Kim, F. Xavier Pi‐Sunyer, Karla A. Temple, Elizabeth M. Venditti, Jill Reedy, Brandy M. Heckman‐Stoddard, George A. Bray, Kishore M. Gadde, Iris W. Culbert, Jennifer Arceneaux, Annie Chatellier, Amber Dragg, Catherine M. Champagne, Crystal Duncan, Barbara Eberhardt, Frank L. Greenway, Fonda G. Guillory, April A. Herbert, Michael L. Jeffirs, Betty M. Kennedy, Erma Levy, Monica Lockett, Jennifer C. Lovejoy, Laura H. Morris, Lee E. Melancon, Donna H. Ryan, Deborah A. Sanford, Kenneth G. C. Smith, Lisa L. Smith, Julia A. St. Amant, Richard T. Tulley, Paula C. Vicknair, Donald Williamson, J. J. Zachwieja, Kenneth S. Polonsky, Janet Tobian, David A. Ehrmann, Margaret J. Matulik, Bart Clark, Kirsten Czech, Catherine DeSandre, Ruthanne Hilbrich, Wylie McNabb, Ann R. Semenske, F. José, Kevin Furlong, Barry J. Goldstein, Pamela G. Watson, Kellie A. Smith, Jewel Mendoza, Wendi Wildman, Renee Liberoni, John Spandorfer, Constance Pepe, Richard P. Donahue, Ronald Goldberg, Ronald J. Prineas, Jeanette Calles, Juliet Ojito, Patricia M. Rowe, Paul Cassanova-Romero, Sumaya Castillo-Florez, Hermes Flórez, Anna Giannella, Lascelles Kirby, Carmen Larreal, Olga Lara, Valerie McLymont, Jadell Mendez, Arlette C. Perry, Patrice G. Saab, Beth Veciana, Steven M. Haffner, Helen P. Hazuda, Maria G. Montez, Kathy Hattaway, Carlos Lorenzo, Arlene Martinez, Tatiana Walker, Dana Dabelea, Richard F. Hamman, Patricia V. Nash, Sheila C. Steinke, Lisa Testaverde, Denise Anderson, Larry B. Ballonoff, Alexis Bouffard, Brian C. Bucca, B. Ned Calonge, Lynne Delve, Martha Farago, James O. Hill, Shelley R. Hoyer, Tonya Jenkins, Bonnie T. Jortberg, Dione Lenz, Marsha Miller, Leigh Perreault, David W. Price, Judith G. Regensteiner, Helen Seagle, Carissa M. Smith, Brent VanDorsten, Edward S. Horton, Kathleen E. Lawton, Catherine S. Poirier, Kati Swift, Ronald A. Arky, Marybeth Bryant, Jacqueline P. Burke, Enrique Caballero, Karen M. Callaphan, Barbara Fargnoli, Therese Franklin, Om P Ganda, Ashley Guidi, Mathew Guido, Sharon D. Jackson, Alan M. Jacobsen, Lori Lambert, Sarah Ledbury, Margaret Kocal, Lyn M. Kula, Maureen A. Malloy, Maryanne Nicosia, Cathryn F. Oldmixon, Jocelyn Pan, Marizel Quitingon, Stacy Rubtchinsky, Jessica Sansoucy, Dana Schweizer, Ellen W. Seely, Donald C. Simonson, Fannie Smith, Caren G. Solomon, Jeanne Spellman, James H. Warram, Steven E. Kahn, Brenda K. Montgomery, Wilfred Y. Fujimoto, Robert H. Knopp, Edward W. Lipkin, Michelle Marr, Ivy Morgan-Taggart, Anne Murillo, Dace Trence, Lonnese Taylor, April Thomas, Elaine C. Tsai, Samuel Dagogo‐Jack, Abbas E. Kitabchi, Mary E. Murphy, Laura Taylor, Jennifer Dolgoff, William B. Applegate, Michael Bryer‐Ash, Debra Clark, Sandra L. Frieson, Uzoma N. Ibebuogu, Raed Imseis, Helen Lambeth, Lynne C. Lichtermann, Hooman Oktaei, Harriet Ricks, Lily M.K. Rutledge, Amy R. Sherman, Clara M. Smith, Judith E. Soberman, Beverly Williams-Cleaves, Boyd E. Metzger, Mark E. Molitch, Mariana K. Johnson, Daphne T. Adelman, Catherine Behrends, Michelle Cook, Marian L. Fitzgibbon, Mimi M. Giles, Deloris Heard, Cheryl K.H. Johnson, Diane Larsen, Anne Lowe, Megan Lyman, David D. McPherson, Samsam C. Penn, Thomas Pitts, Renee Reinhart, Susan Roston, Pamela A. Schinleber, David M. Nathan, Charles McKitrick, Heather Turgeon, Mary Larkin, Kathy Abbott, Ellen J. Anderson, Laurie Bissett, Kristy Bondi, Enrico Cagliero, José C. Florez, Kali D’Anna, Linda M. Delahanty, Valerie Goldman, Peter Lou, Alexandra Poulos, Elyse Raymond, Christine Stevens, Beverly Tseng, Jerrold M. Olefsky, Elizabeth Barrett‐Connor, Mary Lou Carrion-Petersen, Madeline Beltran, Lauren N. Claravall, Jonalle M. Dowden, Steven V. Edelman, Robert R. Henry, Javiva Horne, Marycie Lamkin, Simona Szerdi Janesch, Diana Leos, Sunder Mudaliar, William H. Polonsky, Jean Louise M. Smith, Jennifer Torio-Hurley, Karen Vejvoda, F. Xavier Pi‐Sunyer, Jane E. Lee, David B. Allison, Nnenna Agharanya, Nancy J. Aronoff, Maria Baldo, Jill P. Crandall, Sandra T. Foo, Susan Hagamen, José A. Luchsinger, Carmen Pal, Kathy Parkes, Mary Beth Pena, Ellen S. Rooney, Gretchen E.H. Van Wye, Kristine A. Viscovich, David G. Marrero, Kieren J. Mather, Melvin Prince, Susie M. Kelly, Marcia A. Jackson, Gina McAtee, Paula Putenney, Ronald T. Ackermann, Carolyn M. Cantrell, Yolanda F. Dotson, Edwin S. Fineberg, Megan Fultz, John Guare, Angela Hadden, James M. Ignaut, Marion S. Kirkman, Erin O’Kelly Phillips, Beverly D. Porter, Paris Roach, Nancy Rowland, Madelyn L. Wheeler, Vanita R. Aroda, Robert E. Ratner, Gretchen Youssef, Sue Shapiro, Catherine Bavido-Arrage, Geraldine Boggs, Marjorie Bronsord, Ernestine Brown, Wayman W. Cheatham, Susan Cola, Cindy Evans, Peggy Gibbs, Tracy Kellum, Renee Wiggins, Milvia Lagarda, Lilia Leon, Claresa Levatan, Milajurine Lindsay, Asha K. Nair, Maureen Passaro, Angela Silverman, Gabriel I. Uwaifo, Debra Wells-Thayer, Mohammed Saad, Karol E. Watson, Maria Budget, Sujata Jinagouda, Medhat Botrous, Khan Akbar, Claudia Conzues, Perpetua Magpuri,
The 2018 World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) 3rd expert report highlights up-to-date Cancer Prevention Recommendations that may reduce burdens of many chronic diseases, including diabetes. This study examined if following a lifestyle that aligns with the recommendations - assessed via the 2018 WCRF/AICR Score - was associated with lower risk of type 2 diabetes in high-risk adults participating in the Diabetes Prevention Program Outcomes Study (DPPOS).The Diabetes ...
BioMed Central
James Thomas, Kirsty McGee, Md. Anower Hossain, Gavin D. Perkins, Anthony Gordon, Duncan Young, Daniel F. McAuley, Mervyn Singer, Ranjit Lall, Tina Kramarić, Janet M. Lord, Tony Whitehouse, Luis A. J. Mur, Tonny Veenith, Jaimin Patel, Nick Murphy, Mansoor N. Bangash, Tomasz Torliński, Nick P. Talbot, Catherine Snelson, Dhruv Parekh, Amisha Desai, Mary Kotada, Yin May Chin, Sophie Holden, Aoife Neal, Maximina Ventura, Martin Pope, Samantha Harkett, Christopher McGhee, Emma Fellows, Amy Bamford, Ronald Carrera, Karen Ellis, Elaine Spruce, Liesl Despy, Stephanie Porter, Colin Bergin, Stephanie Goundry, Hazel Smith, Tracy Mason, Natalie Dooley, Amy Clark, Joyce Yeung, Jo Gresty, Teresa Melody, Ellie Reeves, Rachel Smith, Julia Sampson, Chris Nutt, James P. McNamee, Daniel F. McAuley, A. Boyle, Loren McGinley, Chris Wright, Kate A. Ward, Lauren Macartney, Justine Mccann, Brian Johnston, Janette Mills, Leona Bannon, Aisling O’Neill, Stephanie Finn, Anthony Gordon, David Antcliffe, Stephen J. Brett, Dorota Banach, Leilani Cabreros, Laura Curran, Sonia Sousa Arias, Roceld Rojo, Ziortza Fernández de Pinedo Artaraz, Phoebe Coghlan, Maie Templeton, A. Elhaddad, Zohonon Sabine Loko, Gareth J. Barker, Niall MacCallum, David Brealey, Kristian Warnes, Nina Bason, Dorota Filipowicz, Georgia Bercades, Ingrid Hass, Jung Hee Ryu, Deborah Smyth, Dorothy Ilano, Daniel Harvey, Louise Conner, Lucy Ryan, Cecilia Peters, Megan Meredith, Megan K. McAulay, Zoe Whitman, Amy Clark, Lucy Morris, Julia Sampson, C Woodford, Sally Hodgkinson, Sonya Finucane, Luigi Camporota, Manu Shankar‐Hari, Marlies Ostermann, Aneta Bociek, Rosario Lim, Neus GrauNovellas, Natalie Palmer, Angela Cape, Andrea Kelly, Gill Arbane, Sarah Campos, Michael J. Singh, Jinny Yoo, Richard Innes, Fiona C. Dempsey, Patricia Doble, Rebecca Purnell, Moira Tait, J. Hutter, Corinne Pawley, Joy Rowe, Catherine Wane, Richard Burgess, Ashly Thomas, Pulak Paul, Brenda White, Wayne Lovegrove, Mandy Gill, Lynne Wade, Tracy Brear, Vishal Dhokia, Debbie Jackson, Sarah Shelton, Jill Kirk, Andrew J.M. Boulton, Alistair Roy, Anthony Rostron, Zeynep Elcioglu, Lindsey Woods, Sarah Cornell, Rebecca Betts, Jill Holden, Stephen Laybourne, Kimberley Rogerson, Jeremy Bewley, Rebekah Johnson, Anna Chillingworth, Bethany Gumbrill, Hilary Galvin, Kim Wright, Georgia Efford, Kathleen Corcoran, Libby Cole, Katie Sweet, Denise Webster, Lisa Grimmer, Gemma Paris, Chloe Searles, Zoe Garland, Charly Gibson, Melanie Hutchings, Fiona Walters, Sinéad Kelly, Lorraine Scaife, Kelly Littlewood, James Leavy, Shirley Todd, Elizabeth Gordón, Sadie Heddon, Victor Mariano, Karin Gupwell, Rebecca Appelboam, Samantha Keenan, Cassie Brady, Ian Mew, Duncan Chambler, Sarah Williams, Pauline Ashcroft, Patricia Williams, James Rees, Sophie Wiseman, Sarah Horton, Mark Shortland, Stephanie Dukes, Andrew S. Ball, Michael Z. Spivey, Jennie Stephens, Sarah Bean, Karen Burt, Rachel Chapman, Carol Richards, Lorraine Moore, Linda Allsop, Amber Wynn, Louise Latty, Sam Waddy, Kayleigh Spencer, Bethan Stowe, Georgina Cox, Helen McMillan, Liana Lankester, Colin Wells, Rosalyn Squire, Mike Marner, Robert J. Jackson, Nikitas Nikitas, Stuart Dickson, Henrik Reschreiter, J. Bromilow, James Keegan, Chris Loew, Ken Power, Spike Briggs, Julie Camsooksai, Sarah Patch, Sarah M. Jenkins, Sharon Power, Elizabeth Woodward, David Pogson, Zoe Daly, Steve Rose, Aimi Collins, A.L. Phelps, Helen Claridge, Christine Minnis, Sarah K. Inglis, Lutece Brimfield, Charlotte Wong, Ingeborg Welters, Karen Williams, Victoria Waugh, Julie Patrick-Heselton, Emily Johnson, David M. Shaw, Brian Johnston, Maryam Crews, Alicia Waite, Vinoth Sankar, Jonathan R. Walker, Peter Turton, Richard Wenstone, Jaime Fernandez Roman, Alison Hall, Maria Lopez Martinez, David Hamilton, David Coey, Philip Shelley, Martin Goulding, K. L. Kavanagh, Ann Marron, Hannah Allsop, Philip Hopkins, John Smith, Harriet Noble, Evita Pappa, Clare Finney, Sinead Heyler, Emma Clarey, Maeve Cockrell, Maria Depante, Kevin O’Reilly, Christopher C. M. Waterhouse, Vicky Chu, Joanne Gordon, Greg Marchant, Stuart Chandler, Senait Haile, Joanna Flanagan, Gaynor Notcheva, Dom Jimenez, Dilbagh Gill, Sunil Jamadarkhana, Sunita Gohil, Sura Dabbagh, Katy-Jane Chick, Carina Cruz, Vikram Anumakonda, Vanessa Moore, L. K. Pulver, Sharon Westwood, Jacqueline Smith, Karen Reid, R Gidda, Elena Anastasescu, Karim M. Salem, Mohamed Mooradun, Michael Reay, Nasirul Ekbal, Margaret McNeil, Helder Filipe, Aarti Nandani, Glykeria Pakou, Mark De Neef, Sara Mingo, Amitaa Maharajh, Prashanth Nandhabalan,
Abstract Purpose The landiolol and organ failure in patients with septic shock (STRESS-L study) included a pre-planned sub-study to assess the effect of landiolol treatment on inflammatory and metabolomic markers. Methods Samples collected from 91 patients randomised to STRESS-L were profiled for immune and metabolomic markers. A panel of pro- and anti-inflammatory cytokines were measured through commercially acquired multiplex Luminex assays and statistically analysed by individual and cluster-level ...
Springer Nature