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Artigo Acesso aberto Revisado por pares

Harald Kaemmerer, H. Meisner, John Hess, Joseph K. Perloff,

... unknown that in the same year and before Gross, Emil Karl Frey, a surgeon at the Medizinische Akademie ...

Tópico(s): Wireless Power Transfer Systems

2004 - Elsevier BV | The American Journal of Cardiology

Artigo Acesso aberto Revisado por pares

Anish Suri, James J. Walters, Henry W. Rohrs, Michael L. Gross, Emil R. Unanue,

Abstract The diversity of Ags targeted by T cells in autoimmune diabetes is unknown. In this study, we identify and characterize a limited number of naturally processed peptides from pancreatic islet β-cells selected by diabetogenic I-Ag7 molecules of NOD mice. We used insulinomas transfected with the CIITA transactivator, which resulted in their expression of class II histocompatibility molecules and activation of diabetogenic CD4 T cells. Peptides bound to I-Ag7 were isolated and examined by mass ...

Tópico(s): Immune Cell Function and Interaction

2008 - American Association of Immunologists | The Journal of Immunology

Jornais Acesso aberto

Thomas Nichol, A. D. Rockwell, Prof. E. M. Hale, Prof. S. Lilienthal, Dr. George Wegener, Samuel D. Gross, Samuel Lilienthal, Dr. H. Goullon, Stiles Kennedy,

... Goullon, of Wiemar; Translated from the German by Emil Tietze, M. D. ... by Samuel D. Gross, M. D., …, Monobromide of Camphor, On the Distinction ...

0000 - Gale Group | NCCO-STM 1of2

Revisão Revisado por pares

Pamela Gross, Emil P. Kartalov, Axel Scherer, Leslie P. Weiner,

Microfabrication processes have changed the technology used in consumer goods, and have now advanced into applications in biology. Microfluidic platforms are microfabricated tools that are gaining popularity for studies of molecular and cellular biology. These platforms can allow precise control of the environment surrounding individual cells and they have been used to study physiologic and pharmacologic responses at the single-cell level. This article reviews microfluidic technology with emphasis ...

Tópico(s): Microfluidic and Capillary Electrophoresis Applications

2007 - Elsevier BV | Journal of the Neurological Sciences

Artigo Revisado por pares

Daniel Emil Mack, Sonja M. Groß, Robert Vaßen, D. Stöver,

Tópico(s): Glass properties and applications

2006 - Springer Science+Business Media | Journal of Thermal Spray Technology

Jornais Acesso aberto

G. W. Cottis, Dr. John V. Woodruff, F. W. Barrows,

... Meetings, Presidential Address, The Annual Meeting of the Gross Medical Club Was Entertained by Dr. James A. ... of Surgical Operations, Prof. Fedor Krause, and Dr. Emil Heymann, Berlin, Translated and Edited by Dr. Alfred ...

1915 - Gale Group | NCCO-STM 1of2

Artigo Acesso aberto Revisado por pares

Anish Suri, James J. Walters, Matteo Levisetti, Michael L. Gross, Emil R. Unanue,

This report details the biochemical features of natural peptides selected by the H-2Kd class I MHC molecule. In normal cell lines, the length of the naturally processed peptides ranged from 8 to 18 amino acids, although the majority were 9-mers (16% were longer than nine residues). The binding motif for the 9-mer peptides was dominated by the presence of a tyrosine at P2 and an isoleucine/leucine at the P9 position. The P2 residue contributed most towards binding; and the short peptides bound better ...

Tópico(s): T-cell and B-cell Immunology

2006 - Wiley | European Journal of Immunology

Jornais Acesso aberto

From Our Association Football Correspondent, FROM OUR SCHOOLS RUGBY CORRESPONDENT, FROM OUR ROWING CORRESPONDENT, FROM OUR RACKETS CORRESPONDENT, FROM OUR CRICKET CORRESPONDENT, FROM OUR RACING CORRESPONDENT, FROM OUR NORTHERN RACING CORRESPONDENT, FROM OUR NEWMARKET CORRESPONDENT, From Our Golf Correspondent, From Our Labour Staff, FROM OUR CORRESPONDENT, FROM OUR SHIPPING CORRESPONDENT, FROM OUR SCOTTISH CORRESPONDENT, From Our Political Correspondent, FROM OUR POLITICAL CORRESPONDENT, From Our Bridge Correspondent, FROM OUR AGRICULTURAL CORRESPONDENT, By a Shipping Correspondent, FROM OUR SPECIAL CORRESPONDENT, FROM OUR FILM CRITIC, From Our Africa Correspondent, FROM OUR UNITED NATIONS CORRESPONDENT, From Our Own Correspondent, FROM OUR OWN CORRESPONDENT, FROM OUR COMMON MARKET CORRESPONDENT, FROM OUR COMMONWEALTH STAFF, FROM OUR AERONAUTICAL CORRESPONDENT, From Our Aeronautical Correspondent, From Our Diplomatic Correspondent, From Our United Nations Correspondent, FROM OUR PARLIAMENTARY CORRESPONDENT, FRANCIS PORTAL., P. H. PARKIN, W. J. LEAPER, GILBERT DALLEY, MOHAMMED YOUSUF, R. N. REID., MALCOLM HITCHCOCK, MURIEL GAMMANS, WILLIAM DOUGLAS HOME, AXEL HEYST, KITTIE L. DODD., From Our Special Correspondent, DENNIS CHAPMAN, W. C. W. NIXON, J. C. McCLURE BROWNE, A. A. HAWKER, FROM A CORRESPONDENT, Mr John Rodgers, M. R. C., A correspondent, From Our Sale Room Correspondent, FROM OUR NAVAL CORRESPONDENT, By Our City Editor, FROM OUR ESTATES CORRESPONDENT, From Our Common Market Correspondent,

... of South Africa.), Foreign Companies Unifonds Cut Payment Gross Income Falls, Revenue Deficit Of £38M., Wall Street ...

1962 - Gale Group | TDA

Artigo Revisado por pares

Scott B. Lovitch, James J. Walters, Michael L. Gross, Emil R. Unanue,

Abstract Type B T cells recognize peptide provided exogenously but are ignorant of the same epitope derived from intracellular processing. In this study, we demonstrate the existence of type B T cells to an abundant autologous peptide derived from processing of the I-Ak β-chain. T cell hybridomas raised against this peptide fail to recognize syngeneic APC despite abundant presentation of the naturally processed epitope but react in a dose-dependent manner to exogenous peptide. Moreover, these hybridomas ...

Tópico(s): Immune Cell Function and Interaction

2003 - American Association of Immunologists | The Journal of Immunology

Jornais Acesso aberto

A SOLDIER., ARTHUR LEACH., H. LAURANCE, DELAMARK FREEMAN, R. W. F., FROM OUR CORRESPONDENTS., VICTIM., J. WESTLAKE., ONE OF THE THREE HUNDRED., GEORGE DENNIS., DR. ALEXANDER CONZE., CHARLES C. HOOD., DEMETRIUS C. BOULGER., THE DOG'S MISTRESS., WM. JOHN MENZIES., HENRY W. WASSE.,

... and Railway and Other Shares., Traffic Receipts., The gross receipts on the 17 principal railways in the, ...

1882 - Gale Group | TDA

Artigo Acesso aberto Revisado por pares

Anish Suri, James J. Walters, Osami Kanagawa, Michael L. Gross, Emil R. Unanue,

We isolated and identified naturally processed peptides selected by antigen-presenting cells homozygous for expression of I-A g7 or I-A d class II MHC molecules, or from heterozygous antigen-presenting cells that express I-A g7 along with I-A g7PD or I-A d . Identification of large numbers of peptides demonstrated that despite being closely related on a structural level, each class II MHC molecule selected for very unique peptides. The large data sets allowed us to definitively establish the preferred ...

Tópico(s): T-cell and B-cell Immunology

2003 - National Academy of Sciences | Proceedings of the National Academy of Sciences

Jornais Acesso aberto

Jeremy Rundall, Terry Delaney, Charles Raw, Richard Buckle, John Fryer, Alan McElwain, (Mrs) P. M. Holder, Harold Hobson, Peter Marson, John Lambert, Kenneth Pearson, John Bratby, James Poole, Antony Terry, Kenneth Galbrath, John Whale, Julian Symons, Valerie Y. Muir M B ChB, Paddy Kitchen, Patrick Murphy, Philip Oakes, Anne Robinson, Henry Brandon, Vivian Lewis, George Pole chairman, John Russell, Richard Milner, Samuel Beckett, F. A. Bishop, Edwin Morgan, Linda Blandford, Philip Knightley, Philip Clarke, Derek Jewell, Patrick Campbell, Vivian Jenkins, D. H. Stock, (Prof) G. E. R. Burroughs, Murray Sayle, John Ballantine, Norman Harris, Geoff Whitten, David Butler, Peter Kellner, Bryan Silcock Science Correspondent, Robin Marlar, Hugh Somerville, Cyril Connolly, Malcolm Crawford Economics Editor, Brian Moynahan, Dympna Brawn, S. Nathan, Jilly Cooper, Mervyn Benford, Timothy Shaw, John Ball, Boris Schapiro, David Holden, Maxwell Boyd, Michael Wales, Tony Geraghty, Henry Brandon Washington, Nicholas Carroll, Paul Martin, Philip Mason, Derrik Mercer, Bryan Silcock, S. G. Schiller L D S, Roger Mortimer, Eric Jacobs, Malcolm Winton, D. J. Bennington, John Raymond, Ernestine Carter, David Owen, Desmond Shawe-Taylor, Lyman Andrews, Alan Brien, Gwen Nuttall, Edward Heath, Michael Bateman, Jacqueline du Pre, Alexander Mitchell, Lanning Roper, W. Diment, Dilys Powell, Hugh Johnson, B. W. M. Young, David Wiggins, Timothy Johnson Technology Correspondent, Robin Sanders, Felix Aprahamian, Michael Field, David Leitch, Neville Vincent, Judith Cook, Henry Longhurst, Sam Wiggs, Peter Pringle, James Margach Political Correspondent, K. G. Evans, Kenneth Randall, Tony Dawe, Michael Moynihan, Brian Glanville, Margaret Tuck, Michael Connock, Graham Searjeant, Michael Green, Maurice Wiggin, (Mrs) Jane Kelsall, W. Lindsay Neustatter M D, F R C P, Tony Clifton, Michael Parkinson, Nicholas Faith Industrial Editor, Diana Cooper, Edith Bone, John Kenneth Galbraith, G. H. O'd. Alexander, Harlow Unger, Neville Maxwell, Nicholas Tomalin,

... Rutley Multiple Display Advertising Items Harrods Estate Offices Gross Fine Krieger Chalfen Multiple Display Advertising Items D. ...

1969 - Gale Group | Sunday Times HA GDA

Artigo Acesso aberto Revisado por pares

Carlos Velázquez, Ilan Vidavsky, Koen van der Drift, Michael L. Gross, Emil R. Unanue,

The processing by antigen-presenting cells (APC) of the protein hen egg-white lysozyme (HEL) results in the selection of a number of peptide families by the class II major histocompatibility complex (MHC) molecule, I-Ak. Some of these families are expressed in very small amounts, in the order of a few picomoles/109 APC. We detected these peptides from an extract of class II MHC molecules by using monoclonal anti-peptide antibodies to capture the MHC-bound peptides prior to their examination by HPLC ...

Tópico(s): vaccines and immunoinformatics approaches

2002 - Elsevier BV | Journal of Biological Chemistry

Artigo Acesso aberto Revisado por pares

Anish Suri, Ilan Vidavsky, Koen van der Drift, Osami Kanagawa, Michael L. Gross, Emil R. Unanue,

Abstract We demonstrate in this study the great degree of specificity in peptides selected by a class II MHC molecule during processing. In this specific case of the diabetogenic I-Ag7 molecule, the P9 pocket of I-Ag7 plays a critical role in determining the final outcome of epitope selection, a conclusion that is important in interpreting the role of this molecule in autoimmunity. Specifically, we examined the display of naturally processed peptides from APCs expressing either I-Ag7 molecules or ...

Tópico(s): Immune Cell Function and Interaction

2002 - American Association of Immunologists | The Journal of Immunology

Jornais Acesso aberto

Thomas Keep, C. J. B., W. M. Akhurst,

... the "Sunday Times" The Claimant's Provincial Tour Gross Cruelty to Animals Breach of Promise Mysterious Mail- ... Stanley Coal Cutting by MacHinery Mr. Shaw Gustav Emil Devrient The Duke of Leeds William Borrow Lieutenant- ...

1872 - Gale Group | Sunday Times HA GDA

Artigo Acesso aberto Revisado por pares

Raffi Gugasyan, Ilan Vidavsky, Christopher A. Nelson, Michael L. Gross, Emil R. Unanue,

We report here the identification and quantitation of a minor epitope from hen egg white lysozyme (HEL) isolated from the class II MHC molecule I-Ak of APCs. We isolated and concentrated the peptides from the I-Ak extracts by a peptide-specific mAba, followed by their examination by electrospray mass spectrometry. This initial step improved the isolation, recovery, and quantitation and allowed us to identify 13 different minor peptides using the Ab specific for the HEL tryptic fragment 34-45. The ...

Tópico(s): Animal Genetics and Reproduction

1998 - American Association of Immunologists | The Journal of Immunology

Jornais Acesso aberto

G. V. Natzmer, Georg Warnecke, H. Stauder, R. Kleine, Graf Emilio Turati, Ferd. Dickel, H. Karny, Dr. Med. F. Eichelbaum, Dr. Le Roi, A. C. W. Wagner, H. Fruhstorfer, H. Fruhstorfer, Emil Hoffmann, Dr. Athos Mainardi, H. Hedicke, H. Stichel,

... Ameisen Und Termiten, Ueber Die Zoogeographische Zusammensetzung Der Gross-Schmetterlingsfauna Schleswig-Holsteins, Beiträge Zur Neuropteroiden-Fauna Von ...

1915 - Gale Group | NCCO-STM 1of2

Artigo Acesso aberto Revisado por pares

Christopher A. Nelson, Ilan Vidavsky, Nicholas J. Viner, Michael L. Gross, Emil R. Unanue,

Major histocompatibility complex (MHC) class II molecules bind antigenic peptides for display to T lymphocytes. Although the enzymes involved remain to be identified, it is commonly believed that class II associated peptides are released from intact antigens through a series of proteolytic steps carried out inside antigen presenting cells. We have examined the effect of amino acid substitutions on proteolytic processing of the model antigen hen-egg lysozyme (HEL). Altered HEL molecules, engineered ...

Tópico(s): T-cell and B-cell Immunology

1997 - National Academy of Sciences | Proceedings of the National Academy of Sciences

Artigo Acesso aberto Revisado por pares

C. Parra-Lopez, Robert Lindner, Ilan Vidavsky, Michael L. Gross, Emil R. Unanue,

Abstract We compared the processing and presentation of the model Ag, hen-egg white lysozyme (HEL) expressed in C3.F6 APC as a fusion protein to three different acid hydrolases: cathepsin D, to an unglycosylated form of cathepsin D, and to pepsinogen. As expected from the biology of mannose 6-phosphate (Man-6-P)-containing enzyme, cathepsin D-HEL was delivered to the endosomal/lysosomal system. In contrast, the unglycosylated cathepsin D-HEL was retained in ER/Golgi and some was found in lysosomes. ...

Tópico(s): Ubiquitin and proteasome pathways

1997 - American Association of Immunologists | The Journal of Immunology

Jornais Acesso aberto

Frederick Palmer, Ernest Poole, Robert W. Chambers, Matthew Arnold, Mary Brush Williams, Bettina Bedwell, Ruth Gross, Ralph Barton, Sidney Sutherland, Ethel Somers, Frederick James Smith, Charles MacArthur, Knut Stubbendorff, Walter Eckersall, Eileen Bourne, P. G. Wodehouse,

... in Hell Campbell's Packard An Imperial Madman Emil Fannings at His Best, and Some Other Pictures ...

1928 - Gale Group | LibertyMagazine

Artigo Revisado por pares

Stanley Gross, Emil A. Pfitzer, David W. Yeager, Robert A. Kehoe,

Tissues from 46 white males from the Cincinnati area have been analyzed for lead content. Tissue sections and procedures were standardized and detailed information was obtained in order to account for variables such as age, postmortem changes, type of death and pathological conditions. This report focuses on the lead concentrations found in 29 tissues from each person deceased, including their changes with age, and compares the results with those found in the literature. Although lead concentrations ...

Tópico(s): Heavy Metal Exposure and Toxicity

1975 - Elsevier BV | Toxicology and Applied Pharmacology

Artigo

Paul Gross, Emil A. Pfitzer, Ethel B. Tolker, Mary Ann Babyak, Marianne Kaschak,

Tópico(s): Pleural and Pulmonary Diseases

1965 - Heldref Publications | Archives of Environmental Health An International Journal

Artigo Acesso aberto Revisado por pares

Mary J. Guthrie,

... rats from x-ray irradiation of the chestPaul Gross MD, Emil A. Pfitzer ScD, Joseph Watson PhD, Robert T. ...

Tópico(s): Reproductive Biology and Fertility

1958 - Wiley | Cancer

Artigo Revisado por pares

Raffi Gugasyan, Carlos Velázquez, Ilan Vidavsky, B Deck, Koen van der Drift, Michael L. Gross, Emil R. Unanue,

Abstract The protein hen egg white lysozyme (HEL) contains two segments, in tandem, from which two families of peptides are selected by the class II molecule I-Ak, during processing. These encompass peptides primarily from residues 31–47 and 48–63. Mutant HEL proteins were created with changes in residues 52 and 55, resulting in a lack of binding and selection of the 48–63 peptides to I-Ak molecules. Such mutant HEL proteins donated the same amount of 31–47 peptide as did the unmodified protein. ...

Tópico(s): Transgenic Plants and Applications

2000 - American Association of Immunologists | The Journal of Immunology