Emilio Rivera, Katerina Djambazova, Elizabeth K. Neumann, Richard M. Caprioli, Jeffrey M. Spraggins,
... of biological tissues: A brief review and perspective Emilio S. Rivera, Emilio S. RiveraSearch for more papers by this ... M. SpragginsSearch for more papers by this author Emilio S. Rivera, Emilio S. RiveraSearch for more papers by this authorKaterina ...
Tópico(s): Metabolomics and Mass Spectrometry Studies
2020 - Wiley | Journal of Mass Spectrometry
Emilio Rivera, Katerina Djambazova, Elizabeth K. Neumann, Richard M. Caprioli, Jeffrey M. Spraggins,
Abstract Imaging mass spectrometry (IMS) technologies are capable of mapping a wide array of biomolecules in diverse cellular and tissue environments. IMS has emerged as an essential tool for providing spatially targeted molecular information due to its high sensitivity, wide molecular coverage, and chemical specificity. One of the major challenges for mapping the complex cellular milieu is the presence of many isomers and isobars in these samples. This challenge is traditionally addressed using ...
Tópico(s): Metabolomics and Mass Spectrometry Studies
2020 - Wiley | Journal of Mass Spectrometry
David M. Anderson, Jeffrey D. Messinger, Nathan Heath Patterson, Emilio Rivera, Ankita Kotnala, Jeffrey M. Spraggins, Richard M. Caprioli, Christine A. Curcio, Kevin L. Schey,
The human retina provides vision at light levels ranging from starlight to sunlight. Its supporting tissues regulate plasma-delivered lipophilic essentials for vision, including retinoids. The macula is an anatomic specialization for high-acuity and color vision that is also vulnerable to prevalent blinding diseases. The retina's exquisite architecture comprises numerous cell types that are aligned horizontally, yielding structurally distinct cell, synaptic, and vascular layers that are visible ...
Tópico(s): Retinal Diseases and Treatments
2020 - American Chemical Society | Journal of the American Society for Mass Spectrometry
Jésus Emilio Rivera, Rami Eid, Patrick Paultre,
The addition of discrete fibers to the concrete mixture to enhance its toughness and tensile strength is well acknowledged. Studies have also shown that fiber-reinforced concrete (FRC) can be favorable for its enhanced behavior in compression. This behavior, which is attributed to the confinement action of the fibers, is, in general, superior in terms of strength and ductility, compared to plain concrete. Reversed cyclic loading in flexure under constant axial load of large scale synthetic fiber- ...
Tópico(s): Structural Load-Bearing Analysis
2020 - Elsevier BV | Engineering Structures
Katerina Djambazova, Dustin R. Klein, Lukasz G. Migas, Elizabeth K. Neumann, Emilio Rivera, Raf Van de Plas, Richard M. Caprioli, Jeffrey M. Spraggins,
Lipids are a structurally diverse class of molecules with important biological functions including cellular signaling and energy storage. Matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) allows for direct mapping of biomolecules in tissues. Fully characterizing the structural diversity of lipids remains a challenge due to the presence of isobaric and isomeric species, which greatly complicates data interpretation when only m/z information is available. Integrating ...
Tópico(s): Advanced Proteomics Techniques and Applications
2020 - American Chemical Society | Analytical Chemistry
Lauren D. Palmer, Keaton E. Minor, Joshua A. Mettlach, Emilio Rivera, Kelli L. Boyd, Richard M. Caprioli, Jeffrey M. Spraggins, Zachary D. Dalebroux, Eric P. Skaar,
Acinetobacter baumannii is a leading cause of ventilator-associated pneumonia and a critical threat due to multidrug resistance. The A. baumannii outer membrane is an asymmetric lipid bilayer composed of inner leaflet glycerophospholipids and outer leaflet lipooligosaccharides. Deleting mlaF of the maintenance of lipid asymmetry (Mla) system causes A. baumannii to become more susceptible to pulmonary surfactants and antibiotics and decreases bacterial survival in the lungs of mice. Spontaneous suppressor ...
Tópico(s): Bacterial Genetics and Biotechnology
2020 - Cell Press | Cell Reports
Elizabeth K. Neumann, Nathan Heath Patterson, Emilio Rivera, Jamie Allen, Maya Brewer, Mark deCaestecker, Richard M. Caprioli, Agnes B. Fogo, Jeffrey M. Spraggins,
The human kidney is composed of many cell types that vary in their abundance and distribution from normal to diseased organ. As these cell types perform unique and essential functions, it is important to confidently label each within a single tissue to accurately assess tissue architecture and microenvironments. Towards this goal, we demonstrate the use of co-detection by indexing (CODEX) multiplexed immunofluorescence for visualizing 23 antigens within the human kidney. Using CODEX, many of the ...
Tópico(s): Advanced Biosensing Techniques and Applications
2021 - Elsevier BV | Kidney International
Katherine Peters, Emilio Rivera, Cassandra Warden, Paula A. Harlow, Sabrina L. Mitchell, M. Wade Calcutt, David C. Samuels, Milam A. Brantley,
Tópico(s): Retinal Imaging and Analysis
2021 - Elsevier BV | American Journal of Ophthalmology
Emilio Rivera, Benjamin M. Wilkowski, Aaron J. Moss, Cheskie Rosenzweig, Leib Litman,
In recent years, Amazon’s Mechanical Turk (MTurk) has become a pivotal source for participant recruitment in many social-science fields. In the last several years, however, concerns about data quality have arisen. In response, CloudResearch developed an intensive pre-screening procedure to vet the full participant pool available on MTurk and exclude those providing low-quality data. To assess its efficacy, we compared three MTurk samples that completed identical measures: Sample 1 was collected prior ...
Tópico(s): Misinformation and Its Impacts
2022 - | Methodology
Emilio Rivera, Andy Weiss, Lukasz G. Migas, Jeffrey A. Freiberg, Katerina Djambazova, Elizabeth K. Neumann, Raf Van de Plas, Jeffrey M. Spraggins, Eric P. Skaar, Richard M. Caprioli,
Although Staphylococcus aureus is the leading cause of biofilm-related infections, the lipidomic distributions within these biofilms is poorly understood. Here, lipidomic mapping of S. aureus biofilm cross-sections was performed to investigate heterogeneity between horizontal biofilm layers.S. aureus biofilms were grown statically, embedded in a mixture of carboxymethylcellulose/gelatin, and prepared for downstream matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI IMS). ...
Tópico(s): Antibiotic Resistance in Bacteria
2022 - Elsevier BV | Journal of Mass Spectrometry and Advances in the Clinical Lab
Alain P. Gobert, Yvonne L. Latour, Mohammad Asim, Jordan L. Finley, Thomas G. Verriere, Daniel P. Barry, Ginger L. Milne, Paula B. Luis, Claus Schneider, Emilio Rivera, Kristie Lindsey-Rose, Kevin L. Schey, Alberto G. Delgado, Johanna C. Sierra, M. Blanca Piazuelo, Keith T. Wilson,
The reverse transsulfuration pathway is the major route for the metabolism of sulfur-containing amino acids. The role of this metabolic pathway in macrophage response and function is unknown. We show that the enzyme cystathionine γ-lyase (CTH) is induced in macrophages infected with pathogenic bacteria through signaling involving phosphatidylinositol 3-kinase (PI3K)/MTOR and the transcription factor SP1. This results in the synthesis of cystathionine, which facilitates the survival of pathogens within ...
Tópico(s): Sulfur Compounds in Biology
2019 - American Society for Microbiology | mBio
Jeffrey M. Spraggins, Katerina Djambazova, Emilio Rivera, Lukasz G. Migas, Elizabeth K. Neumann, Arne Fuetterer, Juergen Suetering, Niels Goedecke, Alice Ly, Raf Van de Plas, Richard M. Caprioli,
Imaging mass spectrometry (IMS) enables the spatially targeted molecular assessment of biological tissues at cellular resolutions. New developments and technologies are essential for uncovering the molecular drivers of native physiological function and disease. Instrumentation must maximize spatial resolution, throughput, sensitivity, and specificity, because tissue imaging experiments consist of thousands to millions of pixels. Here, we report the development and application of a matrix-assisted ...
Tópico(s): Analytical Chemistry and Chromatography
2019 - American Chemical Society | Analytical Chemistry
Benjamin M. Wilkowski, Adam K. Fetterman, Shaun K. Lappi, Laverl Z. Williamson, Elizabeth Ferguson Leki, Emilio Rivera, Brian P. Meier,
What do people want?Few questions are more fundamental to psychological science than this.Yet, existing taxonomies disagree on both the number and content of goals.We thus adopted a lexical approach and investigated the structure of goal-relevant words from the natural English lexicon.Through an intensive rating process, 1,060 goal-relevant English words were first located.In Studies 1-2, two relatively large and diverse samples (total n = 1,026) rated their commitment to approaching or avoiding these ...
Tópico(s): Cultural Differences and Values
2019 - American Psychological Association | Journal of Personality and Social Psychology
Danxia Yu, Xiao‐Ou Shu, Emilio Rivera, Xianglan Zhang, Qiuyin Cai, M. Wade Calcutt, Yong‐Bing Xiang, Honglan Li, Yu‐Tang Gao, Thomas J. Wang, Wei Zheng,
Background Trimethylamine‐N‐oxide ( TMAO ), a diet‐derived, gut microbial–host cometabolite, has been associated with adverse cardiovascular outcomes in patient populations; however, evidence is lacking from prospective studies conducted in general populations and non‐Western populations. Methods and Results We evaluated urinary levels of TMAO and its precursor metabolites (ie, choline, betaine, and carnitine) in relation to risk of coronary heart disease ( CHD ) among Chinese adults in a nested case–control ...
Tópico(s): Diet and metabolism studies
2019 - Wiley | Journal of the American Heart Association
Silvia Stefánia Longoni, Manuel Sánchez‐Moreno, Jorge Emilio Rivera López, Clotilde Marı́n,
Leishmania spp. are digenetic parasites whose infection occurs inside the mononuclear phagocitary system. The iron superoxide dismutase secreted (Fe-SODe) by promastigotes of Leishmania spp. seems to plays an important role in the defense to environmental detoxification and neutralization of oxidative stress damage caused by reactive oxygen species (ROS) produced by macrophages during the infection. Parasites Fe-SODe is involved in establishing the infection and manifestation of Leishmaniasis. Its ...
Tópico(s): Vector-borne infectious diseases
2013 - Elsevier BV | Comparative Immunology Microbiology and Infectious Diseases
Evelyn Stratmoen, Emilio Rivera, Donald A. Saucier,
We examined the relationships between masculine honor beliefs (MHB) and women’s endorsement of various rejection-related behaviors, as well as both men’s and women’s perceptions of men’s aggressive responses after being romantically rejected by a woman who uses an avoidant/deceptive rejection technique. In Study 1, women with stronger MHB were more likely to endorse their own use of an avoidant/deceptive rejection technique and expressed fewer expectations of men aggressing against them after their ...
Tópico(s): Death Anxiety and Social Exclusion
2019 - SAGE Publishing | Journal of Social and Personal Relationships
Juan Pedro Rojas-Armas, Julio Ruiz Quiroz, Robert Almonacid Román, José Manuel Ortiz-Sánchez, Miriam Pacheco, Luz María Huaroto Valdivia, Emilio Rivera, Roberto Chávez-Asmat, Andrea Anampa,
Tópico(s): Medicinal Plants and Neuroprotection
2016 - | British Microbiology Research Journal
Charles Florez, Young Ho Park, Delia J. Valles-Rosales, Antonio Lara, Emilio Rivera,
Uranium contamination of groundwater increasingly concerns rural residents depending on home wells for their drinking water in communities where uranium is a source of contamination. Established technologies to clean up contaminated aquifers are ineffective in large contaminated areas or are prohibitively expensive. Permeable reactive barriers (PRBs) are a low-cost alternative to these methods. In this paper, the applicability of clay ceramic pellets was investigated as permeable reactive barriers ( ...
Tópico(s): Groundwater flow and contamination studies
2017 - Multidisciplinary Digital Publishing Institute | Water
Francesco Benazzo, Stefano Marco Paolo Rossi, Pietro Maniscalco, Biagio Moretti, Enrico Vaienti, Pietro Ruggieri, Alessandro Massè, Antonio Medici, Alessandro Formica, Bruno Di Maggio, Vincenzo Caiaffa, Mario Mosconi, Luigi Murena, Fabio D’Angelo, Alberto Belluati, Emílio Mazza, Fabrizio Rivera, Alberto Castelli, Matteo Ghiara, Marco Rosolani, Raffaele Cioffi, Raffaele Pezzella, Gabriele Scaravilli, Giovanni Bove, Placido Stissi, Michael Mazzacane, Fabrizio Quattrini, Corrado Ciatti, Giulia Trovarelli, Elisa Pala, Andrea Angelini, Francesco Sanna, Daniela Nonne, Andrea Colombelli, Filippo Raggini, Agnese Puzzo, Gianluca Canton, Guido Maritan, A. Danielle Iuliano, Pietro Randelli, Giuseppe Solarino, Lorenzo Moretti, Giovanni Vicenti, Nunzia Garofalo, Vittorio Nappi, Simone Ripanti, Carmela Chinni, Francesco Pogliacomi, Alberto Visigalli, Nathalie Bini, Alessandro Aprato, Loris Perticarini,
From February 21, the day of hospitalisation in ICU of the first diagnosed case of Covid-19, the social situation and the hospitals' organisation throughout Italy dramatically changed. The CIO (Club Italiano dell'Osteosintesi) is an Italian society devoted to the study of traumatology that counts members spread in public and private hospitals throughout the country. Fifteen members of the CIO, Chairmen of 15 Orthopaedic and Trauma Units of level 1 or 2 trauma centres in Italy, have been involved ...
Tópico(s): Disaster Response and Management
2020 - Springer Science+Business Media | International Orthopaedics
Upasana Bhattacharya, Theocharis Lamprou, Andrew S. Maxwell, Andrés F. Ordóñez, Emilio Pisanty, Javier Rivera-Dean, Philipp Stammer, M. F. Ciappina, Maciej Lewenstein, P. Tzallas,
Strong laser physics is a research direction that relies on the use of high-power lasers and has led to fascinating achievements ranging from relativistic particle acceleration to attosecond science. On the other hand, quantum optics has been built on the use of low photon number sources and has opened the way for groundbreaking discoveries in quantum technology, advancing investigations ranging from fundamental tests of quantum theory to quantum information processing. Despite the tremendous progress, ...
Tópico(s): Quantum Information and Cryptography
2023 - IOP Publishing | Reports on Progress in Physics
Maciej Lewenstein, M. F. Ciappina, Emilio Pisanty, Javier Rivera-Dean, Philipp Stammer, Theocharis Lamprou, P. Tzallas,
The physics of intense laser–matter interactions1,2 is described by treating the light pulses classically, anticipating no need to access optical measurements beyond the classical limit. However, the quantum nature of the electromagnetic fields is always present3. Here we demonstrate that intense laser–atom interactions may lead to the generation of highly non-classical light states. This was achieved by using the process of high-harmonic generation in atoms4,5, in which the photons of a driving ...
Tópico(s): Spectroscopy and Quantum Chemical Studies
2021 - Nature Portfolio | Nature Physics
Hyung‐Suk Yoon, Jae Jeong Yang, Emilio Rivera, Xiao‐Ou Shu, Yong‐Bing Xiang, M. Wade Calcutt, Qiuyin Cai, Xianglan Zhang, Honglan Li, Yu‐Tang Gao, Wei Zheng, Danxia Yu,
Studies have linked several metabolites to the risk of coronary heart disease (CHD) among Western populations, but prospective studies among Asian populations on the metabolite-CHD association remain limited.We evaluated the association of urinary metabolites with CHD risk among Chinese adults in a nested case-control study of 275 incident cases and 275 matched controls (127 pairs of men and 148 pairs of women). Fifty metabolites were measured by a predefined metabolomics panel and adjusted using ...
Tópico(s): Liver Disease Diagnosis and Treatment
2019 - Elsevier BV | Nutrition Metabolism and Cardiovascular Diseases
Emilio Hernández⋆, Pedro Rivera, Bigail Bravo, Jorge Toledo, José Caro‐Corrales, Pablo Montoya,
We determined the thermal death rate constants and mortality curves for the eggs and different instars of Ceratitis capitata (Mediterranean fruit fly) (Wiedemann) submerged in isolation in water at 44, 46, and 48°C and submerged within fruits of Mangifera indica (mango) (L.) in water at 43.1, 44.1, 45.1, and 46.1°C. The first instar was the most tolerant to this treatment, with estimated times for achieving 99.9968% mortality of 103.28, 92.73, and 92.49 min at temperatures of 43.1, 44.1, and 45.1°C, ...
Tópico(s): Insect-Plant Interactions and Control
2012 - Oxford University Press | Journal of Economic Entomology
J.M. Carazo, Francisco F. Rivera, Emilio L. Zapata, Michael Radermacher, J. Frank,
SUMMARY Pattern recognition methods based on the theory of fuzzy sets are tested for their ability to classify electron microscopy images of biological specimens. The concept of fuzzy sets was chosen for its ability to represent classes of objects that are vaguely described from the measured data. A number of partitional clustering algorithms and an extensive set of cluster‐validity functionals (some already reported and some newly developed) have been applied to a test‐data set and to two real‐data ...
Tópico(s): Advanced Chemical Sensor Technologies
1990 - Wiley | Journal of Microscopy
Francisco F. Rivera, Emilio L. Zapata, J.M. Carazo,
We present two new fuzzy cluster validity functionals (minimum and mean hard tendencies), based on the analysis of the hard tendency of the fuzzy classification generated by the fuzzy c-means algorithm. We have used the bootstrap technique, to avoid the possible influence of local minimums, obtained by the fuzzy c-means algorithm.
Tópico(s): Rough Sets and Fuzzy Logic
1990 - Elsevier BV | Pattern Recognition Letters
Patricia Muñóz, P. Álvarez, Fernando de Ory, Francisco Pozo, Marisa Rivera, Emilio Bouza,
Tópico(s): Cytomegalovirus and herpesvirus research
2002 - Wolters Kluwer | Medicine
Barbara Frossi, Juan Rivera, Emilio Hirsch, Carlo Pucillo,
Abstract Mast cells have the ability to react to multiple stimuli, implicating these cells in many immune responses. Specific signals from the microenvironment in which mast cells reside can activate different molecular events that govern distinct mast cells responses. We previously demonstrated that hydrogen peroxide (H2O2) promotes IL-4 and IL-6 mRNA production and potentates FcεRI-induced cytokine release in rat basophilic leukemia RBL-2H3 cells. To further evaluate the effect of an oxidative ...
Tópico(s): Receptor Mechanisms and Signaling
2007 - American Association of Immunologists | The Journal of Immunology
Pilar Escribano, Sandra Recio, Teresa Peláez, Milagros González‐Rivera, Emilio Bouza, Jesús Guinea,
Secondary resistance to azoles in Aspergillus fumigatus isolates from patients taking long-term itraconazole therapy has been described. We studied the acquisition of secondary azole resistance in 20 A. fumigatus isolates with no mutations at codon 54, 98, 138, 220, 432, or 448 in the cyp51A gene. Adjusted conidium inocula (3 × 10(7) CFU/ml) of each isolate were prepared and progressively or directly exposed to increasing itraconazole concentrations, ranging from 0.5 μg/ml to 16 μg/ml. Itraconazole, ...
Tópico(s): Fungal Infections and Studies
2011 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
María Alonso, Marta Herránz, Miguel Martínez‐Lirola, Milagros González‐Rivera, Emilio Bouza, Darı́o Garcı́a de Viedma,
We applied MIRU-VNTR (mycobacterial interspersed repetitive-unit-variable-number tandem-repeat typing) to directly analyze the bacilli present in 61 stain-positive specimens from tuberculosis patients. A complete MIRU type (24 loci) was obtained for all but one (no amplification in one locus) of the specimens (98.4%), and the allelic values fully correlated with those obtained from the corresponding cultures. Our study is the first to demonstrate that real-time genotyping of Mycobacterium tuberculosis ...
Tópico(s): Diagnosis and treatment of tuberculosis
2012 - American Society for Microbiology | Journal of Clinical Microbiology
R. M. Holmes, Juan de Dios Rivera, Emilio de la Jara,
Most studies of large fog collectors (LFC) have focused on the collection efficiency, the amount of water collected, or economic and social aspects, but have not addressed the effects of strong winds on the system. Wind pressure is directly related to fog water collection efficiency but on the other hand may cause serious damage on the structure of LFCs. This study focuses in the effects of wind pressure on the components of the LFC as an integral system, and the ways to face strong winds with no ...
Tópico(s): Spacecraft and Cryogenic Technologies
2014 - Elsevier BV | Atmospheric Research