Hilary Bristow, Helen Connor, Mark Skipworth Consumer Affairs Correspondent, Barbara Hall, Joan Bakewell, David Lea Assistant General Secretary, Pamela Lawson, Mike Graham, John Davison, Jon Swain, Alexandra Frean, Rob Hughes, Mark Honigsbaum, John Peter, Andrew Grice Political Correspondent, Mark Reason, Larry Adler, Graham Lees, Eric Dymock, Tim Judah, Fiona Walsh, Debbie Harrison, Tony Francis, Christopher Somerville, Graham Rose, Philippa Pigache, Norman Howell, Diana Wright Personal Finance Editor, Sally Brompton, Michael Durham Social Affairs Correspondent, David Smith, Susan Espie, Steve Clarke, Nick Pitt, Mike Brearley, Alleen Ballantyne, John Rowland, Edward Welsh, Liz Hodgkinson, Carol Sarler, S Peel, Tom Bullimore, Richard Eaton, Geordie Greig, Tony Allen-Mills, Paolo Farinella, Patrick Stoddart, Robert Sandall, Des Wilson, Iain Johnstone, Peter Plawt, David Brierley, Nigel Stafford-Clark, Tony Schwartz, Irwin Stelzer, George Bundred Chairman, Gureth David, Ivan Fallon, Robert Hewison, Adam Hopkins, H J Piperger, John Mortimer, Geordie Greig Arts Correspondent, Joe Irving, Graham Lyons, Jane Bird, Sally Vincent, Amora Dijon Mustard, Steve Clarke Media Correspondent, Ian Glover-James Diplomatic Correspondent, Meir Vanunu, Geraldine Hackett, David Puttnam, Egon Ronay, Harold Rose, David Kelvin, Margarette Driscoll, Alan Bruce, Hugh Canning, Susan Crosland, David Cairns, Bobby Robson, Cecil Parkinson, David Currie, Robert Harris, Michael Jones, Caroline Lees, George Perry, Sue Mott, Robin Marlar, Iggy Pop, Christopher Gilchrist, David Sweetman, Paul Bailey, Barbara Taylor Bradford, Rex Bellamy, Geoffrey Dicks, Bernard Cafferty, Paul Golding, Ruth Fainlight, Stuart Wavell, Marie Colvin Middle East Correspondent, Paul Donovan, Peter Hounam, Christoper O'Toole, Amit Roy, Peter Lewis, John Owen, Jeff Randall, Jonathan Todd, Paul Driver, Fran Abrams, Roger Scruton, Chris Major, David Hughes, Austin MacCurtain, Tim Rayment, Brian Jackman, Jennie Hawthorne, Joan Forman, Rufus Olins, John Hopkins, Celia Haddon, Brian Walden, S John Peskett Wing Cdr, Roger Williams, David Surtees, Marie-Louise Rossi Chairman, Michael Ignatieff, Christopher Ward, John Karter, David Brittain, Malcolm Winton, Lisa O'kelly, Richard Cook, Craig Brown, Diana Wright, Lesley Newson, Ian Anderson, Stephen Thorpe, Richard Evans, Harry Mullan, Betty Stove, Chris Campling, Anna Robson, Andrew Wheatcroft, Andrew Grice, Martin Searby, Miranda Seymour, Ian Birrell, Janeffe Marshall, Keith Martin, Christine Hope, Dilys Powell, Bryan Appleyard, Andrew Hogg, Alison Beckett, David Selbourne, Norman Stone, W Hagan, John Harvey, Frances Rafferty, Marion Hume, Maurice Chittenden, Nick Hanna, Ian Dunning, Iola Smith, David Sainsbury, John Walsh, Mitchell Symons, Aileen Ballantyne Medical Correspondent, Ruby Millington, Brian MacArthur, Mel Webb, Michael Jones Political Editor, Roger Clarke, Quentin Bell, Andrew Yates, James Blitz, Lawrence Zeegen, Timo Lehtonen, Donald Cameron Watt, John Sharp, Christine Janes, Philip Beresford, Michael Austin, Victoria McKEE, Lord Hailsham, Paul Barker, Brian Glanville, Stan Levenson, John Carey, Norman Macrae, Chris Dighton, Munro Ferguson, John prescott, Godfrey Golzen, John Blauth, Robert Kee, Hana Mandlikova, Gareth David Deputy City Editor, Michael Day Chairman, John Furbisher, David Wickers, Martin J Rehm, Mario Cámpora Ambassador, Douglas Bell, Sam Kiley, Marina Vaizey, Hugh Pearman, Jeff Randall City Editor, Valerie Grove, Richard Caseby, Margaret Park, Angela Long, Frank Field, John Jones, David Smith Economics Editor, Penny Perrick, Kamran Fazel, Tony Hetherington, Barbara Lloyd, Philip Sabin, Joanna Simon, Samuel Hynes, James Park, Marianne Macy, Iain Jenkins, Jack Charlton, Mary Ann Fitzgerald, Michael Kenward, Boris Schapiro,
... corner, Scifo lies in wait Rob Hughes profiles Enzo Scifo of Belgium, the man England must watch most ...
1990 - Gale Group | Sunday Times HA GDA
Antonia Piazzesi, Yiru A. Wang, Joshua Jackson, Lena Wischhof, Viktoria V. Zeisler‐Diehl, Enzo Scifo, Ina Oganezova, Thorben Hoffmann, Pablo Gómez Martín, Fabio Bertan, Chester J. J. Wrobel, Frank C. Schroeder, Dan Ehninger, Kristian Händler, Joachim L. Schultze, Lukas Schreiber, Gerhild van Echten‐Deckert, Pierluigi Nicotera, Daniele Bano,
... Search for more papers by this author Enzo Scifo Enzo Scifo orcid.org/0000-0002-0450-6573 German ... Search for more papers by this author Enzo Scifo Enzo Scifo orcid.org/0000-0002-0450-6573 German Center ...
Tópico(s): Coenzyme Q10 studies and effects
2022 - Springer Nature | EMBO Reports
Sabine Koch, Enzo Scifo, Anne Rokka, Pascal Trippner, Maria Lindfors, Reeta Korhonen, Garry L. Corthals, Ismo Virtanen, Maciej Łałowski, Jaana Tyynelä,
Cathepsin D deficiency is a fatal neurodegenerative disease characterized by extreme loss of neurons and myelin. Our previous studies have demonstrated that structural and functional alterations in synapses are central to the disease pathogenesis. Therefore, we took a systematic approach to examine the synaptic proteome in cathepsin D knock-out mice, where the synaptic pathology resembles that of human patients. We applied quantitative mass spectrometry analysis on synaptosomal fractions isolated ...
Tópico(s): Bone Metabolism and Diseases
2012 - Elsevier BV | Neurobiology of Disease
Enzo Scifo, Agnieszka Szwajda, Janusz Dębski, Kristiina Uusi-Rauva, Tapio Kesti, Michał Dadlez, Anne‐Claude Gingras, Jaana Tyynelä, Marc Baumann, Anu Jalanko, Maciej Łałowski,
Neuronal ceroid lipofuscinoses (NCL) are the most common inherited progressive encephalopathies of childhood. One of the most prevalent forms of NCL, Juvenile neuronal ceroid lipofuscinosis (JNCL) or CLN3 disease (OMIM: 204200), is caused by mutations in the CLN3 gene on chromosome 16p12.1. Despite progress in the NCL field, the primary function of ceroid-lipofuscinosis neuronal protein 3 (CLN3) remains elusive. In this study, we aimed to clarify the role of human CLN3 in the brain by identifying CLN3- ...
Tópico(s): Cellular transport and secretion
2013 - American Chemical Society | Journal of Proteome Research
Katrin Kollmann, Kristiina Uusi-Rauva, Enzo Scifo, Jaana Tyynelä, Anu Jalanko, Thomas Braulke,
Neuronal ceroid lipofuscinoses (NCL) comprise a group of inherited lysosomal disorders with variable age of onset, characterized by lysosomal accumulation of autofluorescent ceroid lipopigments, neuroinflammation, photoreceptor- and neurodegeneration. Most of the NCL-related genes encode soluble and transmembrane proteins which localize to the endoplasmic reticulum or to the endosomal/lysosomal compartment and directly or indirectly regulate lysosomal function. Recently, exome sequencing led to the ...
Tópico(s): Calcium signaling and nucleotide metabolism
2013 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Saara Tikka, Evanthia Monogioudi, Athanasios Gotsopoulos, Rabah Soliymani, Francesco Pezzini, Enzo Scifo, Kristiina Uusi-Rauva, Jaana Tyynelä, Marc Baumann, Anu Jalanko, Alessandro Simonati, Maciej Łałowski,
Tópico(s): Cellular transport and secretion
2015 - Springer Science+Business Media | NeuroMolecular Medicine
Enzo Scifo, Agnieszka Szwajda, Rabah Soliymani, Francesco Pezzini, Marzia Bianchi, Arvydas Dapkunas, Janusz Dębski, Kristiina Uusi-Rauva, Michał Dadlez, Anne‐Claude Gingras, Jaana Tyynelä, Alessandro Simonati, Anu Jalanko, Marc Baumann, Maciej Łałowski,
Neuronal ceroid lipofuscinoses (NCL) are a group of inherited progressive childhood disorders, characterized by early accumulation of autofluorescent storage material in lysosomes of neurons or other cells. Clinical symptoms of NCL include: progressive loss of vision, mental and motor deterioration, epileptic seizures and premature death. CLN1 disease (MIM#256730) is caused by mutations in the CLN1 gene, which encodes palmitoyl protein thioesterase 1 (PPT1). In this study, we utilised single step affinity ...
Tópico(s): Cellular transport and secretion
2015 - Elsevier BV | Journal of Proteomics
Enzo Scifo, Mohan Pabba, Fenika Kapadia, Tianzhou Ma, David A. Lewis, George C. Tseng, Etienne Sibille,
Major depressive disorder (MDD) is a debilitating mental illness and a major cause of lost productivity worldwide. MDD patients often suffer from lifelong recurring episodes of increasing severity, reduced therapeutic response, and shorter remission periods, suggesting the presence of a persistent and potentially progressive pathology.Subgenual anterior cingulate cortex postmortem samples from four MDD cohorts (single episode, n = 20; single episode in remission, n = 15; recurrent episode, n = 20; and recurrent ...
Tópico(s): Bipolar Disorder and Treatment
2017 - Elsevier BV | Biological Psychiatry
Fernando Caravaggio, Enzo Scifo, Etienne Sibille, Sergio E. Hernández-Da Mota, Philip Gerretsen, Gary Remington, Ariel Graff‐Guerrero,
Tópico(s): Glaucoma and retinal disorders
2018 - Elsevier BV | Experimental Eye Research
Vignesh Srinivasan, Céline Bruelle, Enzo Scifo, Dan Duc Pham, Rabah Soliymani, Maciej Łałowski, Dan Lindholm,
USP14 is a deubiquitinating enzyme associated with the proteasome important for protein degradation. Here we show that upon proteasome inhibition or expression of the mutant W58A-USP14, association of USP14 with the 19S regulatory particle is disrupted. MS-based interactomics revealed an interaction of USP14 with the chaperone, HSC70, in neuroblastoma cells. Proteasome inhibition enhanced binding of USP14 to HSC70, and to XBP1u and IRE1α proteins, demonstrating a role in the unfolded protein response. ...
Tópico(s): Autophagy in Disease and Therapy
2019 - Cell Press | iScience
Yushuang Deng, Avadh Kumar, Kan Xie, Kristina Schaaf, Enzo Scifo, Sarah Morsy, Tao Li, Armin Ehninger, Daniele Bano, Dan Ehninger,
Abstract This study investigates the efficacy of NKG2D chimeric antigen receptor (CAR) engineered T cells in targeting and eliminating stress-induced senescent cells in vitro. Cellular senescence contributes to age-related tissue decline and is characterized by permanent cell cycle arrest and the senescence-associated secretory phenotype (SASP). Immunotherapy, particularly CAR-T cell therapy, emerges as a promising approach to selectively eliminate senescent cells. Our focus is on the NKG2D receptor, ...
Tópico(s): RNA Interference and Gene Delivery
2024 - Springer Nature | Cell Death Discovery
Lena Wischhof, Enzo Scifo, Dan Ehninger, Daniele Bano,
Apoptosis-inducing factor (AIF) is a mitochondrial intermembrane space flavoprotein with diverse functions in cellular physiology.In this regard, a large number of studies have elucidated AIF's participation to chromatin condensation during cell death in development, cancer, cardiovascular and brain disorders.However, the discovery of rare AIFM1 mutations in patients has shifted the interest of biomedical researchers towards AIF's contribution to pathogenic mechanisms underlying inherited AIFM1-linked ...
Tópico(s): interferon and immune responses
2022 - Elsevier BV | EBioMedicine
Kan Xie, Helmut Fuchs, Enzo Scifo, Dan Liu, Ahmad Aziz, Juan Antonio Aguilar‐Pimentel, Oana V. Amarie, Lore Becker, Patricia da Silva‐Buttkus, Julia Calzada‐Wack, Yi-Li Cho, Yushuang Deng, A. Cole Edwards, Lillian Garrett, Christina Georgopoulou, Raffaele Gerlini, Sabine M. Hölter, Tanja Klein‐Rodewald, Michael Kramer, Stefanie Leuchtenberger, Dimitra Lountzi, Phillip Mayer-Kuckuk, Lena L. Nover, Manuela A. Oestereicher, Clemens Overkott, Brandon L. Pearson, Birgit Rathkolb, Jan Rozman, Jenny Russ, Kristina Schaaf, Nadine Spielmann, Adrián Sanz‐Moreno, Claudia Stoeger, Irina Treise, Daniele Bano, Dirk H. Busch, Jochen Graw, Martin Klingenspor, Thomas Klopstock, Beverly A. Mock, Paolo Salomoni, Carsten B. Schmidt‐Weber, Marco Weiergräber, Eckhard Wolf, Wolfgang Wurst, Valérie Gailus‐Durner, Monique M.B. Breteler, Martin Hrabé de Angelis, Dan Ehninger,
Abstract Current concepts regarding the biology of aging are primarily based on studies aimed at identifying factors regulating lifespan. However, lifespan as a sole proxy measure for aging can be of limited value because it may be restricted by specific pathologies. Here, we employ large-scale phenotyping to analyze hundreds of markers in aging male C57BL/6J mice. For each phenotype, we establish lifetime profiles to determine when age-dependent change is first detectable relative to the young ...
Tópico(s): Stress Responses and Cortisol
2022 - Nature Portfolio | Nature Communications
Mohan Pabba, Enzo Scifo, Fenika Kapadia, Yuliya S. Nikolova, Tianzhou Ma, Naguib Mechawar, George C. Tseng, Etienne Sibille,
The orbitofrontal cortex (OFC) is vulnerable to normal and pathologic aging. Currently, layer resolution large-scale proteomic studies describing "normal" age-related alterations at OFC are not available. Here, we performed a large-scale exploratory high-throughput mass spectrometry–based protein analysis on OFC layer 2/3 from 15 "young" (15–43 years) and 18 "old" (62–88 years) human male subjects. We detected 4193 proteins and identified 127 differentially expressed (DE) proteins (p-value ≤0.05; effect ...
Tópico(s): Genetic Neurodegenerative Diseases
2017 - Elsevier BV | Neurobiology of Aging
Enzo Scifo, Agnieszka Szwajda, Rabah Soliymani, Francesco Pezzini, Marzia Bianchi, Arvydas Dapkunas, Janusz Dębski, Kristiina Uusi-Rauva, Michał Dadlez, Anne‐Claude Gingras, Jaana Tyynelä, Alessandro Simonati, Anu Jalanko, Marc Baumann, Maciej Łałowski,
Mutations in the CLN1 gene that encodes Palmitoyl protein thioesterase 1 (PPT1) or CLN1, cause Infantile NCL (INCL, MIM#256730). PPT1 removes long fatty acid chains such as palmitate from modified cysteine residues of proteins. The data shown here result from isolated protein complexes from PPT1-expressing SH-SY5Y stable cells that were subjected to single step affinity purification coupled to mass spectrometry (AP-MS). Prior to the MS analysis, we utilised a modified filter-aided sample preparation ( ...
Tópico(s): Advanced Proteomics Techniques and Applications
2015 - Elsevier BV | Data in Brief
Christoffer Karlsson, Magnus Blom, Miranda Johansson, Anna Jansson, Enzo Scifo, Anders Karlén, Thavendran Govender, Adolf Gogoll,
Incorporation of an artificial amino acid 2 with a stilbene chromophore into peptidomimetics with three to nine amino acids yields phototriggerable candidates for inhibition of the binding between the R1 and R2 subunits of the M. tuberculosis ribonucleotide reductase (RNR). Interstrand hydrogen bond probability was used as a guideline for predicting conformational preferences of the photoisomers. Binding of these inhibitors has been rationalized by docking studies with the R1 unit. Significant differences ...
Tópico(s): Click Chemistry and Applications
2014 - Royal Society of Chemistry | Organic & Biomolecular Chemistry
Enzo Scifo, Giulio Calza, Martin Fuhrmann, Rabah Soliymani, Marc Baumann, Maciej Łałowski,
Introduction: Neurological disorders encompass various pathologies which disrupt normal brain physiology and function. Poor understanding of their underlying molecular mechanisms and their societal burden argues for the necessity of novel prevention strategies, early diagnostic techniques and alternative treatment options to reduce the scale of their expected increase.Areas covered: This review scrutinizes mass spectrometry based approaches used to investigate brain dynamics in various conditions, ...
Tópico(s): Mass Spectrometry Techniques and Applications
2017 - Taylor & Francis | Expert Review of Proteomics
Fabio Bertan, Lena Wischhof, Enzo Scifo, Mihaela Guranda, Joshua Jackson, Anaïs Marsal-Cots, Antonia Piazzesi, Miriam Stork, Michael Peitz, Jochen Herbert Martin Prehn, Dan Ehninger, Pierluigi Nicotera, Daniele Bano,
Mitochondria sustain the energy demand of the cell. The composition and functional state of the mitochondrial oxidative phosphorylation system are informative indicators of organelle bioenergetic capacity. Here, we describe a highly sensitive and reproducible method for a single-cell quantification of mitochondrial CI- and CIV-containing respiratory supercomplexes (CI∗CIV-SCs) as an alternative means of assessing mitochondrial respiratory chain integrity. We apply a proximity ligation assay (PLA) ...
Tópico(s): Metabolism and Genetic Disorders
2021 - Elsevier BV | Cell Reports Methods
Joshua Jackson, Christian Hoffmann, Enzo Scifo, Han Wang, Lena Wischhof, Antonia Piazzesi, Mrityunjoy Mondal, Hanna Shields, Xuesi Zhou, Magali Mondin, Eanna B Ryan, Hermann Döring, Jochen H.M. Prehn, Klemens Rottner, Grégory Giannone, Pierluigi Nicotera, Dan Ehninger, Dragomir Milovanović, Daniele Bano,
Abstract Abnormal intraneuronal accumulation of soluble and insoluble α-synuclein (α-Syn) is one of the main pathological hallmarks of synucleinopathies, such as Parkinson’s disease (PD). It has been well documented that the reversible liquid-liquid phase separation of α-Syn can modulate synaptic vesicle condensates at the presynaptic terminals. However, α-Syn can also form liquid-like droplets that may convert into amyloid-enriched hydrogels or fibrillar polymorphs under stressful conditions. To ...
Tópico(s): Alzheimer's disease research and treatments
2024 - Springer Nature | Cell Death and Disease
Joshua Jackson, Lena Wischhof, Enzo Scifo, Anna Pellizzer, Yiru Wang, Antonia Piazzesi, Debora Gentile, Sana Siddig, Miriam Stork, Christopher E. Hopkins, Kristian Händler, Joachim Weis, Andreas Roos, Joachim L. Schultze, Pierluigi Nicotera, Dan Ehninger, Daniele Bano,
Mitochondrial "retrograde" signaling may stimulate organelle biogenesis as a compensatory adaptation to aberrant activity of the oxidative phosphorylation (OXPHOS) system. To maintain energy-consuming processes in OXPHOS deficient cells, alternative metabolic pathways are functionally coupled to the degradation, recycling and redistribution of biomolecules across distinct intracellular compartments. While transcriptional regulation of mitochondrial network expansion has been the focus of many studies, ...
Tópico(s): Biochemical Acid Research Studies
2022 - Elsevier BV | Molecular Metabolism
... Massimo Venturini, , Angelo Vanzulli, , Sandro Sironi, , Marco Salvioni, , Enzo Angeli, , Paola Scifo, , Maria Paola Garancini, , Rita Quartagno, , Giuseppe Bianchi, , and ...
Tópico(s): Renal and Vascular Pathologies
1992 - Radiological Society of North America | Radiology
Francesco De Cobelli, Massimo Venturini, Angelo Vanzulli, Sandro Sironi, Marco Salvioni, Enzo Angeli, Paola Scifo, Maria Paola Garancini, R. Quartagno, Giuseppe Bianchi, Alessandro Del Maschio,
PURPOSE: To compare color Doppler ultrasonography (US) with fast, breath-hold, three-dimensional, gadolinium-enhanced magnetic resonance (MR) angiography in detecting renal arterial stenosis. MATERIALS AND METHODS: Forty-five patients with clinical suspicion of renovascular disease were prospectively examined with intra- and extrarenal color Doppler US and breath-hold, gadolinium-enhanced MR angiography. Digital subtraction arteriography (DSA) was the standard of reference in all patients for the number ...
Tópico(s): Advanced MRI Techniques and Applications
2000 - Radiological Society of North America | Radiology
Marco Distefano, Marco Lorenza Di, Scifo Enzo, Gruttadauria Salvo, Scifo Gaetano, Marco Vito Di,
Clinical trials and real word data have proven that chronic hepatitis C (HCV) can be eradicated (sustained virological response SVR or 'cure') in the majority of patients by direct - acting antivirals (DAAs) . There are, however, groups of patients in whom HCV treatment outcomes with direct acting antivirals (DAAs) are suboptimal (genotype (GT) 3 patients, decompensated cirrhosis, renal failure) or have not been studied in large cohorts (patients with relapse to a previous DAAs treatment (failure)). This case ...
Tópico(s): Systemic Lupus Erythematosus Research
2019 - | Journal of Clinical Gastroenterology and Treatment
Srinivasan Vignesh, Bruelle Celine, Scifo Enzo, Pham Dan Duc, Rabah Soliymani, Lalowski Maciej, Lindholm Dan,
2020 - Cell Press | iScience
Fabio Bertan, Lena Schmid, Enzo Scifo, Mihaela Guranda, Joshua Jackson, Anaïs Marsal-Cots, Antonia Piazzesi, Miriam Stork, Michael Peitz, Jochen H.M. Prehn, Dan Ehninger, Pierluigi Nicotera, Daniele Bano,
Mitochondria sustain the energy demand of the cell. The composition and functional state of the mitochondrial oxidative phosphorylation system are informative indicators of organelle homeostasis and bioenergetic capacity. Here we describe a highly sensitive and reproducible method for single-cell visualization and quantification of mitochondrial respiratory supercomplexes as a novel means of measuring mitochondrial respiratory chain integrity. We apply a proximity ligation assay (PLA) and perform ...
Tópico(s): RNA modifications and cancer
2020 - RELX Group (Netherlands) | SSRN Electronic Journal
Adrián Sanz‐Moreno, Lore Becker, Kan Xie, Patricia da Silva‐Buttkus, Nathalia Romanelli Vicente Dragano, Juan Antonio Aguilar‐Pimentel, Oana V. Amarie, Julia Calzada‐Wack, Markus Kraiger, Stefanie Leuchtenberger, Claudia Seisenberger, Susan Marschall, Birgit Rathkolb, Enzo Scifo, Ting Liu, Anoja Thanabalasingam, Raúl Sánchez-Vazquez, Paula Felippe Martinez, Marı́a A. Blasco, Sharon A. Savage, Helmut Fuchs, Dan Ehninger, Valérie Gailus‐Durner, Martin Hrabé de Angelis,
Tópico(s): Microplastics and Plastic Pollution
2025 - American Association for the Advancement of Science | Science Advances
Kan Xie, Chengfeng Wang, Enzo Scifo, Brandon L. Pearson, Devon Ryan, Kristin S. Henzel, Astrid Markert, Kristina Schaaf, Xue Mi, Xin Tian, Jiajia Jia, Meiqin Wang, Stefan Bonn, Manuel Schölling, Christoph B. Möhl, Daniele Bano, Yu Zhou, Dan Ehninger,
Tópico(s): Circadian rhythm and melatonin
2025 - Cell Press | Cell Metabolism
Enzo Scifo, Agnieszka Szwajda, Janusz Dębski, Kristiina Uusi-Rauva, Tapio Kesti, Michał Dadlez, Anne‐Claude Gingras, Jaana Tyynelä, Marc Baumann, Anu Jalanko, Maciej Łałowski,
ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionORIGINAL ARTICLEThis notice is a correctionCorrection to Drafting the CLN3 Protein Interactome in SH-SY5Y Human Neuroblastoma Cells: A Label-free Quantitative Proteomics ApproachEnzo Scifo*, Agnieszka Szwajda, Janusz Dębski, Kristiina Uusi-Rauva, Tapio Kesti, Michał Dadlez, Anne-Claude Gingras, Jaana Tyynelä, Marc H. Baumann, Anu Jalanko, and Maciej Lalowski*Cite this: J. Proteome Res. 2013, 12, 8, 3822Publication Date (Web):July 9, 2013Publication ...
Tópico(s): Cancer, Hypoxia, and Metabolism
2013 - American Chemical Society | Journal of Proteome Research
Vignesh Srinivasan, Céline Bruelle, Enzo Scifo, Dan Duc Pham, Rabah Soliymani, Maciej Łałowski, Dan Lindholm,
USP14 is a deubiquitinating enzyme associated with the proteasome, important for protein degradation. Here we show that upon proteasomal inhibition, or expressing the mutant W58A-USP14, the association of USP14 with the 19S regulatory particle is disrupted. MS-based interactomics revealed an interaction of USP14 with the chaperone, HSC70. Proteasome inhibition enhanced binding of USP14 to HSC70, but also to XBP1u and IRE1α proteins, demonstrating a role in the unfolded protein response. Striatal ...
Tópico(s): Ubiquitin and proteasome pathways
2019 - RELX Group (Netherlands) | SSRN Electronic Journal
Sinéad A. O’Sullivan, Rita Pinto‐Costa, Ayşe Ulusoy, Shirley S. L. Lee, Enzo Scifo, Dan Ehninger, Donato A. Di Monte,
Tópico(s): Neurological Disorders and Treatments
2024 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - Bioenergetics