Victor Yashunsky, Leorah Kharilker, Efrat Zlotkin‐Rivkin, David Rund, Naomi Melamed‐Book, Eitan Erez Zahavi, Eran Perlson, Silvana Mercone, M. Golosovsky, Dan Davidov, Benjamin Aroeti,
Enteropathogenic Escherichia coli (EPEC) is an important, generally non-invasive, bacterial pathogen that causes diarrhea in humans. The microbe infects mainly the enterocytes of the small intestine. Here we have applied our newly developed infrared surface plasmon resonance (IR-SPR) spectroscopy approach to study how EPEC infection affects epithelial host cells. The IR-SPR experiments showed that EPEC infection results in a robust reduction in the refractive index of the infected cells. Assisted ...
Tópico(s): Listeria monocytogenes in Food Safety
2013 - Public Library of Science | PLoS ONE
Olga Shomron, Inbar Nevo-Yassaf, Tamar Aviad, Yakey Yaffe, Eitan Erez Zahavi, Anna Dukhovny, Eran Perlson, Ilya Brodsky, Adva Yeheskel, Metsada Pasmanik‐Chor, Anna Mironov, Galina V. Beznoussenko, Alexander A. Mirоnоv, Ella H. Sklan, George H. Patterson, Yoji Yonemura, Mara Sannai, Christoph Kaether, Koret Hirschberg,
COPII and COPI mediate the formation of membrane vesicles translocating in opposite directions within the secretory pathway. Live-cell and electron microscopy revealed a novel mode of function for COPII during cargo export from the ER. COPII is recruited to membranes defining the boundary between the ER and ER exit sites, facilitating selective cargo concentration. Using direct observation of living cells, we monitored cargo selection processes, accumulation, and fission of COPII-free ERES membranes. ...
Tópico(s): Nuclear Structure and Function
2021 - Rockefeller University Press | The Journal of Cell Biology
Eitan Erez Zahavi, Roy Maimon, Eran Perlson,
Neurons are highly polarized cells, possessing long axons that can extend to more than 1‐m long in adult humans. In order to survive and maintain proper functions, neurons have to respond accurately in both space and time to intracellular or intercellular cues. The regulation of these comprehensive responses involves ligand‐receptor interactions, trafficking and local protein synthesis. Alterations in these mechanisms can lead to cellular dysfunction and disease. Although studies on the transport ...
Tópico(s): Neuroscience and Neuropharmacology Research
2017 - Wiley | Traffic
Ariel Ionescu, Eitan Erez Zahavi, Tal Gradus, Keren Ben‐Yaakov, Eran Perlson,
Molecular communication between the motoneuron and the muscle is vital for neuromuscular junction (NMJ) formation and maintenance. Disruption in the structure and function of NMJs is a hallmark of various neurodegenerative processes during both development and pathological events. Still due to the complexity of this process, it is very difficult to elucidate the cellular mechanisms underlying it, generating a keen interest for developing better tools for investigating it. Here we describe a simplified ...
Tópico(s): Pluripotent Stem Cells Research
2015 - Elsevier BV | European Journal of Cell Biology
Shani Gluska, Eitan Erez Zahavi, Michael Chein, Tal Gradus, Anja Bauer, Stefan Finke, Eran Perlson,
Rabies virus (RABV) is a neurotropic virus that depends on long distance axonal transport in order to reach the central nervous system (CNS). The strategy RABV uses to hijack the cellular transport machinery is still not clear. It is thought that RABV interacts with membrane receptors in order to internalize and exploit the endosomal trafficking pathway, yet this has never been demonstrated directly. The p75 Nerve Growth Factor (NGF) receptor (p75NTR) binds RABV Glycoprotein (RABV-G) with high affinity. ...
Tópico(s): Bacillus and Francisella bacterial research
2014 - Public Library of Science | PLoS Pathogens
Tara Zahavi, Eran Bar‐Kalifa, Haran Sened, Eshkol Rafaeli,
Capitalization interactions within romantic couples, in which they share positive events with each other, are significantly tied to their satisfaction and overall wellbeing. Recent work suggests that social anxiety is negatively associated with beneficial capitalization interactions (i.e., making capitalization bids and responding with active and constructive responses). To further investigate this understanding, we offer a deeper and differentiating look at two core components of social anxiety: ...
Tópico(s): Perfectionism, Procrastination, Anxiety Studies
2018 - Guilford Press | Journal of Social and Clinical Psychology
Eitan Erez Zahavi, Ariel Ionescu, Shani Gluska, Tal Gradus, Keren Ben‐Yaakov, Eran Perlson,
Bidirectional molecular communication between the motoneuron and the muscle is vital for neuromuscular junction (NMJ) formation and maintenance. The molecular mechanisms underlying such communication are of keen interest and may provide new targets for intervention in motor neuron disease. Here we developed a microfluidic platform with motoneuron (MN) cell bodies on one side and muscle cells on the other, connected via motor axons extending through microgrooves to form functional NMJs. Using this ...
Tópico(s): Muscle Physiology and Disorders
2015 - The Company of Biologists | Journal of Cell Science
Eitan Erez Zahavi, Noam Steinberg, Topaz Altman, Michael Chein, Yuvraj Joshi, Tal Gradus-Pery, Eran Perlson,
Tropomyosin-related tyrosine kinase B (TrkB) is the receptor for brain-derived neurotrophic factor (BDNF) and provides critical signaling that supports the development and function of the mammalian nervous system. Like other receptor tyrosine kinases (RTKs), TrkB is thought to signal as a dimer. Using cell imaging and biochemical assays, we found that TrkB acted as a monomeric receptor at the plasma membrane regardless of its binding to BDNF and initial activation. Dimerization occurred only after ...
Tópico(s): Receptor Mechanisms and Signaling
2018 - American Association for the Advancement of Science | Science Signaling
Bavat Bornstein, Eitan Erez Zahavi, Sivan Gelley, Maayan Zoosman, Shiri P. Yaniv, Ora Fuchs, Ziv Porat, Eran Perlson, Oren Schuldiner,
Developmental axon pruning is essential for normal brain wiring in vertebrates and invertebrates. How axon pruning occurs in vivo is not well understood. In a mosaic loss-of-function screen, we found that Bsk, the Drosophila JNK, is required for axon pruning of mushroom body γ neurons, but not their dendrites. By combining in vivo genetics, biochemistry, and high-resolution microscopy, we demonstrate that the mechanism by which Bsk is required for pruning is through reducing the membrane levels ...
Tópico(s): Plant Molecular Biology Research
2015 - Cell Press | Neuron
A CRISPR-based tool reveals intestinal microbiota gene expression through time.
Tópico(s): Probiotics and Fermented Foods
2022 - American Association for the Advancement of Science | Science
Tara Zahavi-Lupo, Gal Lazarus, Rony Pshedetzky‐Shochat, Eran Bar‐Kalifa, Elad Refoua, Marci E. J. Gleason, Eshkol Rafaeli,
Hope is a mental resource and a robust predictor of well-being, which allows individuals to better cope with hardship. Little is known about dyadic hope – i.e., hope serving as a joint resource within intimate relationships. We examined dyadic hope in a sample of 100 couples in early parenthood, a challenging though common phase in couples' lives. Three months after becoming parents, both partners completed daily diaries for 3 weeks, reporting their daily hope, stressors, and three types of outcomes: ...
Tópico(s): Family Dynamics and Relationships
2022 - Routledge | The Journal of Positive Psychology
Liron Zahavi, Amit Lavon, Lee Reicher, Saar Shoer, Anastasia Godneva, Sigal Leviatan, Michal Rein, Omer Weissbrod, Adina Weinberger, Eran Segal,
Genome-wide association studies (GWASs) have provided numerous associations between human single-nucleotide polymorphisms (SNPs) and health traits. Likewise, metagenome-wide association studies (MWASs) between bacterial SNPs and human traits can suggest mechanistic links, but very few such studies have been done thus far. In this study, we devised an MWAS framework to detect SNPs and associate them with host phenotypes systematically. We recruited and obtained gut metagenomic samples from a cohort ...
Tópico(s): Folate and B Vitamins Research
2023 - Nature Portfolio | Nature Medicine
Izhak Levi, Michael Gurevich, Gal Perlman, David Magalashvili, Shay Menascu, Noam Bar, Anastasia Godneva, Liron Zahavi, Danyel Chermon, Noa Kosower, Bat Chen Wolf, Gal Malka, Maya Lotan‐Pompan, Adina Weinberger, Erez Yirmiya, Daphna Rothschild, Sigal Leviatan, Avishag Tsur, Maria Didkin, Sapir Dreyer-Alster, Hen Eizikovitz, Yamit Titngi, Sue Mayost, Polina Sonis, Mark Dolev, Yael Stern, Anat Achiron, Eran Segal,
Multiple sclerosis (MS) is an immune-mediated disease whose precise etiology is unknown. Several studies found alterations in the microbiome of individuals with MS, but the mechanism by which it may affect MS is poorly understood. Here we analyze the microbiome of 129 individuals with MS and find that they harbor distinct microbial patterns compared with controls. To study the functional consequences of these differences, we measure levels of 1,251 serum metabolites in a subgroup of subjects and ...
Tópico(s): Mycobacterium research and diagnosis
2021 - Elsevier BV | Cell Reports Medicine
Olga Shomron, Inbar Nevo-Yassaf, Tamar Aviad, Yakey Yaffe, Eitan Erez Zahavi, Anna Dukhovny, Eran Perlson, Ilya Brodsky, Adva Yeheskel, Metsada Pasmanik-Chor, Anna Mironov, Galina V. Beznoussenko, Alexander A. Mirоnоv, Ella H. Sklan, George H. Patterson, Yoji Yonemura, Christoph Kaether, Koret Hirschberg,
COPII and COPI are considered to be analogous sets of vesicle coat protein hretrocomplexes. Coupled to cargo selection, they mediate the formation of membrane vesicles translocating in opposite directions to different destinations within the secretory pathway. Here, live cell and electron microscopy provided evidence for a different localization and mode of function of the COPII coat during protein export from the endoplasmic reticulum (ER). Pharmaceutical and genetic perturbations of ER-Golgi transport ...
Tópico(s): Superconductivity in MgB2 and Alloys
2019 - RELX Group (Netherlands) | SSRN Electronic Journal
Lee Reicher, Noam Bar, Anastasia Godneva, Yotam Reisner, Liron Zahavi, Nir Shahaf, Raja Dhir, Adina Weinberger, Eran Segal,
Tópico(s): Dietary Effects on Health
2024 - Nature Portfolio | Nature Aging
... more complex role in the biology of MNs (Zahavi et al., 2017). Indeed, Sema3A was shown to ...
Tópico(s): Neurogenetic and Muscular Disorders Research
2019 - Medknow | Neural Regeneration Research
Eran Leshem‐Rubinow, Guy Zahavi, Maria Grazia Bongiorni, Angelo Auricchio, Christian Butter, Nikolaos Dagres, Jean‐Claude Deharo, Christopher A. Rinaldi, Aldo P. Maggioni, Andrzej Kutarski, Charles Kennergren, Cécile Laroche, Ștefan Bogdan, David Mörtsell, Valéria Calvi, Roy Beinart, Quentin Désiron, Jacques Mansourati, Michael Glikson, Carina Blomström Lundqvist, Eyal Nof,
Cardiac implantable electronic devices (CIED) tranvenous lead extraction (TLE) among patients that are pacemaker dependent is more cumbersome, as patients usually require a pacing solution during the procedure and following device extraction, increasing procedure complexity and duration. When infection is the driving reason for extraction, the overlap of temporary pacing until a new device can be implanted can result in lack of microorganism clearance and unfavorable outcomes.
Tópico(s): Cardiac pacing and defibrillation studies
2021 - Elsevier BV | Heart Rhythm
Byron J. Smith, Chunyu Zhao, Veronika Dubinkina, Xiaofan Jin, Liron Zahavi, Saar Shoer, Jacqueline Moltzau Anderson, Eran Segal, Katherine S. Pollard,
Tópico(s): Genomics and Phylogenetic Studies
2025 - Cold Spring Harbor Laboratory Press | Genome Research