Thomas A. P. Seery, Maryam Yassini, Thieo E. Hogen‐Esch, Eric J. Amis,
... A. P. Seery, Maryam Yassini, Thieo E. Hogen-Esch, and Eric J. AmisCite this: Macromolecules 1992, 25, 18, 4784– ...
Tópico(s): High voltage insulation and dielectric phenomena
1992 - American Chemical Society | Macromolecules
Aldo Jongejan, Herman D. Lim, Rogier A. Smits, Iwan J. P. de Esch, Eric Haaksma, Rob Leurs,
A three-dimensional homology model of the human histamine H 4 receptor was developed to investigate the binding mode of a series of structurally diverse H 4-agonists, i.e. histamine, clozapine, and the recently described selective, nonimidazole agonist VUF 8430. Mutagenesis studies and docking of these ligands in a rhodopsin-based homology model revealed two essential points of interactions in the binding pocket, i.e. Asp3.32 and Glu5.46 (Ballesteros-Weinstein numbering system). It is postulated ...
Tópico(s): Chemical Synthesis and Analysis
2008 - American Chemical Society | Journal of Chemical Information and Modeling
Sabine Schultes, Saskia Nijmeijer, Harald Engelhardt, Albert J. Kooistra, Henry F. Vischer, Iwan J. P. de Esch, Eric Haaksma, Rob Leurs, Chris de Graaf,
Computational prediction of ligand binding modes in G protein-coupled receptors (GPCRs) remains a challenging task. Systematic consideration of different protein modelling templates, ligand binding poses, and ligand protonation states in extensive molecular dynamics (MD) simulation studies enabled the prediction of ligand-specific mutation effects in the histamine H 4 receptor, a key player in inflammation.
Tópico(s): Chemical Synthesis and Analysis
2012 - Royal Society of Chemistry | MedChemComm
Gerald W. Esch, Eric J. Wetzel, Derek A. Zelmer, Anna M. Schotthoefer,
-A series of studies on the population and community ecology of several digenetic trematodes was begun in 1983 in a small, eutrophic impoundment in the Piedmont area of North Carolina. Initially, efforts were focused on the hemiurid trematode, Halipegus occidualis. Prevalence of this parasite in its snail intermediate host, Helisoma anceps, reached 60% in late June-early July, then dropped precipitously as the mature cohort of the snail host died-off. Over the next 13 yr, this annual pattern consistently ...
Tópico(s): Primate Behavior and Ecology
1997 - University of Notre Dame | The American Midland Naturalist
Govert Veldhuijzen, Michael Klemt‐Kropp, Casper Noomen, Aura van Esch, Eric T.T.L. Tjwa, Joost P.H. Drenth,
Better patient education prior to colonoscopy improves adherence to instructions for bowel preparation and leads to cleaner colons. We reasoned that computer assisted instruction (CAI) using video and 3 D animations followed by nurse contact maximizes the effectiveness of nurse counselling, increases proportion of clean colons and improves patient experience. Adults referred for colonoscopy in a high-volume endoscopy unit in the Netherlands were included. Exclusion criteria were illiteracy in Dutch ...
Tópico(s): Esophageal Cancer Research and Treatment
2017 - Thieme Medical Publishers (Germany) | Endoscopy International Open
Eberhard Buse, Martina Zöller, Eric van Esch,
... and Eberhard Buse are employed by Covance Inc. Eric Van Esch is employed by Schering-Plough. No other competing ...
Tópico(s): Hypothalamic control of reproductive hormones
2008 - SAGE Publishing | Toxicologic Pathology
Gerhard F. Weinbauer, Marc Niehoff, Michael Niehaus, Shiela Srivastav, Antje Fuchs, Eric van Esch, J. Mark Cline,
... and Antje Fuchs are employed by Covance Inc. Eric Van Esch is employed by Schering-Plough. No other competing ...
Tópico(s): Neuroendocrine regulation and behavior
2008 - SAGE Publishing | Toxicologic Pathology
Eveline P. C. T. de Rijk, Eric van Esch,
... Plough. Eveline P. C. T. de Rijk and Eric Van Esch are employed by Schering-Plough. No other competing ...
Tópico(s): Birth, Development, and Health
2008 - SAGE Publishing | Toxicologic Pathology
Eric van Esch, J. Mark Cline, Eberhard Buse, Charles E. Wood, Eveline P. C. T. de Rijk, Gerhard F. Weinbauer,
... Inc. Eveline P. C. T. de Rijk and Eric Van Esch are employed by Schering-Plough. No other competing ...
Tópico(s): Animal Vocal Communication and Behavior
2008 - SAGE Publishing | Toxicologic Pathology
Eric van Esch, J. Mark Cline, Eberhard Buse, Gerhard F. Weinbauer,
... and Eberhard Buse are employed by Covance Inc. Eric Van Esch is employed by Schering-Plough. No other competing ...
Tópico(s): Hypothalamic control of reproductive hormones
2008 - SAGE Publishing | Toxicologic Pathology
Franz‐Rudolf Esch, Jan Eric Rempel,
Marketing ZFP is a platform for the academic dialog between marketing science and marketing practice. It offers critical depictions of the newest developments in the central areas of marketing science and marketing practice. Thereby, Marketing ZFP dedicates itself particularly to the transfer of methodological knowledge into practice.
Tópico(s): Digital Innovation in Industries
2007 - C.H. Beck | Marketing ZFP
Shaomin Chen, Ulf Riebesell, Kai G. Schulz, Elisabeth von der Esch, Eric P. Achterberg, Lennart T. Bach,
Abstract. Oxygen minimum zones (OMZs) are characterized by enhanced carbon dioxide (CO2) levels and low pH and are being further acidified by uptake of anthropogenic atmospheric CO2. With ongoing intensification and expansion of OMZs due to global warming, carbonate chemistry conditions may become more variable and extreme, particularly in the eastern boundary upwelling systems. In austral summer (February–April) 2017, a large-scale mesocosm experiment was conducted in the coastal upwelling area off ...
Tópico(s): Marine Bivalve and Aquaculture Studies
2022 - Copernicus Publications | Biogeosciences
Eric van Esch, Eveline P. C. T. de Rijk, Eberhard Buse, Martina Zöller, J. Mark Cline,
... Inc. Eveline P. C. T. de Rijk and Eric Van Esch are employed by Schering-Plough. No other competing ...
Tópico(s): Animal testing and alternatives
2008 - SAGE Publishing | Toxicologic Pathology
Eveline P. C. T. de Rijk, Eric van Esch, Gert Flik,
The rat is commonly used as a model in studies on embryology and reproduction toxicology. Surprisingly, the current literature does not provide a comprehensive reference data set on placental development in rat. Therefore, we have evaluated morphological changes of the placenta and maternal blood parameters during pregnancy of the Sprague-Dawley rat. The morphologic data presented in this study may be useful as reference material. This study revealed that placental development in the rat is a well- ...
Tópico(s): Electrolyte and hormonal disorders
2002 - SAGE Publishing | Toxicologic Pathology
Eveline P. C. T. de Rijk, Wilma T.M. Ravesloot, Theo Hafmans, Eric van Esch,
A high incidence of multifocal ductal hyperplasia was observed in the submandibular salivary gland of rats treated for 26 weeks with a high dose of a novel synthetic steroid with combined estrogenic and progestagenic properties. Hyperplastic foci consisted of microcystic duct-like structures lined by a single or multilayered epithelium, sometimes showing a tendency towards a cribiform growth pattern. The hyperplastic ducts wereembedded in a collagen-rich stroma and surrounded by numerous myoepithelial ...
Tópico(s): Cancer and Skin Lesions
2003 - SAGE Publishing | Toxicologic Pathology
Eveline P. C. T. de Rijk, Wilma T.M. Ravesloot, Yvonne M. Wijnands, Eric van Esch,
Hyaline droplet formation in the proximal tubular cells of the kidney commonly occurs under different pathological conditions in experimental animals. In rats, intracytoplasmic hyaline droplet formation is predominantly associated with accumulation of the male rat-specific α2u-globulin, whereas under other (pathological) conditions (eg, histiocytic sarcoma and chronic progressive nephropathy [CPN]) other proteins are involved. Staining methods to visualize hyaline droplets either need plastic embedded ...
Tópico(s): Chronic Kidney Disease and Diabetes
2003 - SAGE Publishing | Toxicologic Pathology
Jan-Peter H. T. M. Ploemen, Wilma T.M. Ravesloot, Eric van Esch,
The incidence of thymic B cell lymphoid follicles was retrospectively studied in 62 male and 58 female healthy control beagle dogs (age 11.3 +/- 4.8, range 6 to 23 months). The animals were selected from toxicological studies performed in the period 1990-2001 at the Organon labs. The animals had received vehicle treatment. Thorough microscopic examination of the thymus in hematoxylin & eosin (H&E)-stained sections resulted in an unexpectedly high overall incidence of 70% of medullary lymphoid follicles. ...
Tópico(s): Diabetes and associated disorders
2003 - SAGE Publishing | Toxicologic Pathology
J. Mark Cline, Charles E. Wood, Justin D. Vidal, Ross P. Tarara, Eberhard Buse, Gerhard F. Weinbauer, Eveline P. C. T. de Rijk, Eric van Esch,
The authors describe a selection of normal findings and common naturally occurring lesions in the reproductive system of female macaques, including changes in the ovaries, uterus, cervix, vagina, and mammary glands. Normal features of immature ovaries, uteri, and mammary glands are described. Common non-neoplastic lesions in the ovaries include cortical mineralization, polyovular follicles, cysts, ovarian surface epithelial hyperplasia, and ectopic ovarian tissue. Ovarian neoplasms include granulosa ...
Tópico(s): Reproductive Physiology in Livestock
2008 - SAGE Publishing | Toxicologic Pathology
Eric van Esch, W. Neal Simmons, Georgy Sankin, Hadley F. Cocks, Glenn M. Preminger, Pei Zhong,
A simple method for preparing artificial kidney stones with varying physical properties is described. BegoStone was prepared with a powder-to-water ratio ranging from 15:3 to 15:6. The acoustic properties of the phantoms were characterized using an ultrasound transmission technique, from which the corresponding mechanical properties were calculated based on elastic wave theory. The measured parameters for BegoStone phantoms of different water contents are: longitudinal wave speed (3,148–4,159 m/s), ...
Tópico(s): Ultrasound and Cavitation Phenomena
2010 - Springer Science+Business Media | Urological Research
Henriette C. Dreef, Eric van Esch, Eveline P. C. T. de Rijk,
The cynomolgus monkey (Macaca fascicularis) is widely used in regulatory toxicity studies. Especially in studies on male contraception, the male reproductive tract can be an important target system. The aim of the present paper is to describe a practical approach for morphological staging of spermatogenesis in routinely prepared paraffin sections. Results obtained using this approach could help to determine possible drug-related effects on spermatogenesis. As a guide to the investigators, photomicrographs ...
Tópico(s): Reproductive Biology and Fertility
2007 - SAGE Publishing | Toxicologic Pathology
Jan-Peter H. T. M. Ploemen, J. Kelder, Theo Hafmans, Han van de Sandt, Johan A. van Burgsteden, P. J. M. Salemink, Eric van Esch,
Several cationic amphiphilic compounds are known to induce phospholipidosis, a condition primarily characterized by excessive accumulation of phospholipids in different cell types, giving the affected cells a finely foamy appearance. Excessive storage of lamellar membranous intralysosomal inclusion bodies is the hallmark for phospholipidosis on the electron microscopic level. In case of alveolar phospholipidosis, foamy macrophages accumulate within the alveolar spaces of the lung. Based on such ...
Tópico(s): Neonatal Respiratory Health Research
2004 - Elsevier BV | Experimental and Toxicologic Pathology
Paul Brady, Nathalie Brison, K Van Den Bogaert, Thomy de Ravel, Hilde Peeters, Hilde Van Esch, Koenraad Devriendt, Eric Legius, Joris Vermeesch,
Non‐invasive prenatal testing ( NIPT ) for fetal aneuploidy detection is increasingly being offered in the clinical setting. Whereas the majority of tests only report fetal trisomies 21, 18 and 13, genome‐wide analyses have the potential to detect other fetal, as well as maternal, aneuploidies. In this review, we discuss the technical and clinical advantages and challenges associated with genome‐wide cell‐free fetal DNA profiling.
Tópico(s): Parvovirus B19 Infection Studies
2015 - Wiley | Clinical Genetics
Eric W. Esch, Anthony Bahinski, Dongeun Huh,
Tópico(s): Microfluidic and Bio-sensing Technologies
2015 - Nature Portfolio | Nature Reviews Drug Discovery
I. Zayed, Eric van Esch, R.F. McConnell,
Four groups of 3 male and 3 female sexually mature Beagle dogs were treated daily po with either ethinyl estradiol (EE) or estradiol (E 2 ). A fifth group of 4 males and 4 females acted as a control group. Three groups of dogs were treated with EE: One group was treated at dose levels of 2.0, 1.5, and 1.0 mg/kg for 6 mo; the other 2 groups received either 0.5 mg/kg or 1.0 mg/kg for 1 yr. The fourth group was treated with 5.0 mg/kg E 2 for 1 yr. Results obtained for the clinical, hematological, and biochemical ...
Tópico(s): Hypothalamic control of reproductive hormones
1998 - SAGE Publishing | Toxicologic Pathology
Swen Lehmann, Eric van Esch, Philipp Hartmann, Anand Goswami, Stefan Nikolin, Joachim Weis, Cordian Beyer, Sonja Johann,
Aims Amyotrophic lateral sclerosis (ALS) is characterized by degeneration of motoneurons and progressive muscle wasting. Inflammatory processes, mediated by non‐neuronal cells, such as glial cells, are known to contribute to disease progression. Inflammasomes consist of pattern recognition receptors (PRRs), apoptosis‐associated speck‐like protein (ASC) and caspase 1 and are essential for interleukin (IL) processing and a rapid immune response after tissue damage. Recently, we described inflammasome ...
Tópico(s): Inflammasome and immune disorders
2018 - Wiley | Neuropathology and Applied Neurobiology
Karyn Colman, Rachel N. Andrews, Hannah Atkins, Theresa Boulineau, Alys Bradley, Annamaria Braendli-Baiocco, Raffaella Capobianco, David L. Caudell, Mark Cline, Takuya Doi, Ernst Rainer, Eric van Esch, Jeffrey I. Everitt, Pierluigi Fant, Margarita M. Gruebbel, Lars Mecklenburg, A. D. Miller, Kristen J. Nikula, Shigeru Satake, Julie Schwartz, Alok Sharma, Akihito Shimoi, Cécile Sobry, Ian L. Taylor, Vimala Vemireddi, Justin D. Vidal, Charles E. Wood, John L. Vahle,
The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions Project (www.toxpath.org/inhand.asp) is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP) and North America (STP) to develop an internationally accepted nomenclature for proliferative and nonproliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature for classifying microscopic lesions observed ...
Tópico(s): Carcinogens and Genotoxicity Assessment
2021 - Japanese Society of Toxicologic Pathology | Journal of Toxicologic Pathology
Darlene Dixon, Roger Alison, Ute Bach, Karyn Colman, George L. Foley, Johannes H. Harleman, Richard Haworth, Ronald Herbert, Anke Heuser, Gerald G. Long, Michael Mirsky, Karen Regan, Eric van Esch, F. Russell Westwood, Justin D. Vidal, Midori Yoshida,
The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) Project (www.toxpath.org/inhand.asp) is a joint initiative of the Societies of Toxicological Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP) and North America (STP) to develop an internationally accepted nomenclature for proliferative and nonproliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature for classifying microscopic ...
Tópico(s): Carcinogens and Genotoxicity Assessment
2014 - Japanese Society of Toxicologic Pathology | Journal of Toxicologic Pathology
Mohamed Slaoui, H. C. Dreef, Eric van Esch,
Tópico(s): Adipokines, Inflammation, and Metabolic Diseases
1998 - SAGE Publishing | Toxicologic Pathology
Sylvia W. M Greijdanus-van der Putten, Eric van Esch, Jan Kamerman, Leo Ballering, Diels J. van den Dobbelsteen, Eveline P. C. T. de Rijk,
As part of regulatory safety testing program, a 13-week oral toxicity study with a new antipsychotic drug candidate was performed in beagle dogs. During this study, dark red/brown feces were recorded in treated dogs and increases in liver parameters (alanine aminotransferase, alkaline phosphatase, bilirubin) were measured biochemically. At the end of the study, livers of high-dose (50 mg/kg) animals were (mottled) dark brown, sometimes with pale foci. Histopathological examination of these livers showed ...
Tópico(s): Heme Oxygenase-1 and Carbon Monoxide
2005 - SAGE Publishing | Toxicologic Pathology
Fred Esch, Pamela S. Keim, Eric C. Beattie, Russell Blacher, Alan R. Culwell, Tilman Oltersdorf, Donald McClure, Pamela J. Ward,
The amyloid β peptide (AβP) is a small fragment of the much larger, broadly distributed amyloid precursor protein (APP). Abundant AβP deposition in the brains of patients with Alzheimer's disease suggests that altered APP processing may represent a key pathogenic event. Direct protein structural analyses showed that constitutive processing in human embryonic kidney 293 cells cleaves APP in the interior of the AβP, thus preventing AβP deposition. A deficiency of this processing event may ultimately ...
Tópico(s): Protein Structure and Dynamics
1990 - American Association for the Advancement of Science | Science