Motowo Nakajima, Eriko Tamura, Tatsuro Irimura, Satoshi Toyoshima, Hiroshi Hirano, Toshiaki Osawa,
When chicken erythrocytes labeled with a stearic acid derivative spin label were treated with concanavalin A (Con A), ESR spectra showed a change in the peaks due to the labels in membrane lipids, indicating an increase of membrane lipid fluidity. Addition of Con A increased the fluidity rapidly. This change was reversible only up to 30 min after adding Con A, and thereafter it gradually became irreversible. However, if the erythrocytes were treated with cytochalasin B and methyl a-D-mannoside, a ...
Tópico(s): Blood properties and coagulation
1981 - Oxford University Press | The Journal of Biochemistry
Toshikazu Takata, Kimie Hoshino, Eriko Takeuchi, Yoshiharu Tamura, Wataru Andō,
In the photooxidation of 3-acyl-2,2-dimethyl-4(R)-substituted thiazolidine derivatives, 5(R)-hydroxy derivative obtained was found to be derived from the 5-hydroperoxy derivative which was isolated and characterized.
Tópico(s): Organic Chemistry Cycloaddition Reactions
1984 - Elsevier BV | Tetrahedron Letters
Hideaki Nagai, Harumi Shishido, Ryozo Yoneda, Eriko Yamaguchi, Atsuhisa Tamura, Atsuyuki Kurashima,
Although diffuse panbronchiolitis (DPB) has carried a poor prognosis, long-term low-dose administration of erythromycin (EM) is very effective. We administered EM at a daily dose of 400-600 mg to 19 DPB subjects for more than 2 months. Sixteen subjects were relieved from productive cough and dyspnea, and their chest X-ray pictures were improved. We performed a pharmacokinetic study of EM in 11 DPB subjects (8 responders; 3 nonresponders) after the long-term low-dose administration. The maximal serum ...
Tópico(s): Transplantation: Methods and Outcomes
1991 - Karger Publishers | Respiration
Eriko Sato, Hiroshi Tamura, Akikazu Matsumoto,
Polyperoxides containing peroxy bonds as the main-chain repeating units are a new class of degradable polymers because of significant changes in their molecular weight and physical properties during a degradation process. In this study, the application of linear and network polyperoxides to dismantlable adhesion was investigated. When the linear polyperoxide obtained from methyl sorbate and oxygen (PP-MS) was used as a pressure-sensitive adhesive (PSA), its shear holding power and 180° peel strength ...
Tópico(s): Photopolymerization techniques and applications
2010 - American Chemical Society | ACS Applied Materials & Interfaces
Yoshiyuki Masaki, Masataka Sumiyoshi, Satoru Suwa, Hiroshi Ohta, Eriko Matsunaga, Hiroshi Tamura, Norihide Takaya, Yoriaki Mineda, Satoshi Kojima, Yasuro Nakata,
Dissection of the sinus of Valsalva is an extremely rare accident during percutaneous coronary intervention (PCI), but it can lead to serious complications such as dissection of the ascending aorta. We experienced a localized dissection of the right coronary cusp without coronary artery involvement that was induced by a guiding catheter during PCI in a patient with acute myocardial infarction. The localized dissection showed pooling of the contrast medium in the acute phase, but it subsided spontaneously ...
Tópico(s): Aortic Disease and Treatment Approaches
2005 - Japanese Heart Journal Assoc | International Heart Journal
Asako Mihashi, Hiroshi Tamura, Eriko Sato, Akikazu Matsumoto,
We have synthesized degradable network polymers containing readily labile peroxy bonds as the repeating units in the main chain or as the cross-linking point in the side chain. Poly(2-hydroxyethyl sorbate-alt-O2) was obtained by the radical copolymerization of 2-hydroxyethyl sorbate with oxygen, and then cross-linked using tolylene 2,4-diisocyanate as the cross-linking agent to obtain a new type of degradable gel. We also investigated the cross-linking of conventional polymers by the reaction of ...
Tópico(s): Photopolymerization techniques and applications
2009 - Elsevier BV | Progress in Organic Coatings
Kazuhiko Nakano, Hiroaki Inaba, Ryota Nomura, Hirotoshi Nemoto, Kiyoko Tamura, Eriko Miyamoto, Hideo Yoshioka, K Taniguchi, Atsuo Amano, Takashi Ooshima,
Actinobacillus actinomycetemcomitans, an important pathogen in periodontitis, has also been detected in cardiovascular tissues. Sixty heart valves were collected during valve replacement surgery from 60 patients (one from each), 10 were from patients with infective endocarditis (IE group) and 50 were from patients with other valvular diseases (non-IE group). In addition, 46 samples of aneurysmal tissue were taken from 46 patients with a thoracic or abdominal aneurysm (Aneurysm group, one from each). ...
Tópico(s): Streptococcal Infections and Treatments
2007 - Wiley | Oral Microbiology and Immunology
Fusako Nagai, Eriko Kato, Hiro-omi Tamura,
To explore the effects of oxidative stress on metabolizing enzymes in blood cells, we examined the effect of hydrogen peroxide (H(2)O(2)) on glutathione S-transferase (GST) and cytochrome P450 (CYP) expression in a human erythroleukemic cell line, K562. After adding H(2)O(2) (up to 100 microM) to the culture medium of K562 cells, the expression levels of GST and CYP enzymes were monitored by RT-PCR. The expression of GSTP1 and CYP3A4 was induced by oxidative stress. Quantitative PCR and immunoblot analysis ...
Tópico(s): Pharmacogenetics and Drug Metabolism
2004 - Pharmaceutical Society of Japan | Biological and Pharmaceutical Bulletin
Yukie Yaguchi, Tomomi Komura, Noriko Kashima, Miho Tamura, Eriko Kage‐Nakadai, Shigeru Saeki, Keiji Terao, Yoshikazu Nishikawa,
Nutritional control has been proposed as a potential therapy for slowing the senescence of immune function and decreasing mortality. This study investigated whether sesamin could modify host defense systems and extend the lifespan of the nematode Caenorhabditis elegans. Nematodes were fed standard food (the bacterium Escherichia coli strain OP50) supplemented with various doses of sesamin/γ-cyclodextrin inclusion compounds starting from young adulthood. The mean lifespan, muscle function, lipofuscin ...
Tópico(s): Sesame and Sesamin Research
2014 - Springer Science+Business Media | European Journal of Nutrition
Risa Tamura, Eriko Kitamura, Ryosuke Tsutsumi, Masahiro Yamanaka, Takahiko Akiyama, Keiji Mori,
Developed herein is a diastereoselective synthesis of CF3-substituted spiroisochromans via C(sp3)–H bond functionalization involving sequential transformations ([1,5]-hydride shift/cyclization/elimination of MeOH/intramolecular Friedel–Crafts reaction).
Tópico(s): Synthesis and Catalytic Reactions
2019 - American Chemical Society | Organic Letters
Yasumori Sujino, Fumiko Kimura, Jun Tanno, Shintaro Nakano, Eriko Yamaguchi, Jiaqi Shi, Nanami Okano, Yuichi Tamura, Jun Fujita, Leslie T. Cooper, Takaaki Senbonmatsu, Toshihiro Muramatsu, Shigeyuki Nishimura,
... MD, PhD, Jun Tanno, MD, Shintaro Nakano, MD, Eriko Yamaguchi, MD, Michio Shimizu, MD, PhD, Nanami Okano, MD, Yuichi Tamura, MD, PhD, Jun Fujita, MD, PhD, Leslie T. ...
Tópico(s): Pericarditis and Cardiac Tamponade
2014 - Lippincott Williams & Wilkins | Circulation
Tetsuo Hirano, Hiroko Matsuzaki, Masakazu Miura, Eriko Kojima, Noboru Tamura, Takamitsu Sekine,
We found extremely low (6 U/l) serum lactate dehydrogenase (LDH, EC 1.1.1.27) activity in a patient with uterine myoma. The patient's serum inhibited purified LDH isoenzymes. One milliliter serum neutralized 73 U purified LDH-1 isoenzyme, equivalent to 300–500-fold the amount of LDH in 1 ml of normal serum. The serum inhibitor was purified by ordinary procedures using chromatographies and identified as IgG which contains both κ- and λ-chains. The IgG is very unique in showing higher affinity to the ...
Tópico(s): Pancreatic function and diabetes
1986 - Elsevier BV | Clinica Chimica Acta
Eriko Nishio, Yayoi Ichiki, Hiroto Tamura, Shirô Morita, K. Watanabe, Hiromichi Yoshikawa,
Topsoil samples were collected from 36 different paddy fields in West Japan. Each soil sample was incubated with a basal salt-medium containing 0.2% OPPEO. Twelve samples possessed OPPEO-degrading activity, from which twelve cultures of OPPEO-degrading bacteria were isolated. The isolated bacteria grew on a medium containing 0.2% OPPEO as the sole carbon source, and OP2EO and OP3EO were accumulated in the medium under aerobic conditions. OP1EO and octylphenol, which have often been identified in ...
Tópico(s): Microbial bioremediation and biosurfactants
2002 - Oxford University Press | Bioscience Biotechnology and Biochemistry
Sachiko Iwata, Osuke Iwata, Alan Bainbridge, Tomohiko Nakamura, Hideki Kihara, Eriko Hizume, Masatoshi Sugiura, Masanori Tamura, Toyojiro Matsuishi,
Abstract Preterm infants are at significant risk of neuro‐developmental disorders at school‐age. MRI is a potentially useful screening tool of such disorders. Using FLAIR imaging in the preterm infants at term, here we demonstrate that abnormal low‐intensity signal in the white matter predicts the neuro‐developmental outcome at 6 years. Study design Clinical factors associated with white matter appearance on MRI obtained at term were investigated in 210 preterm infants. Results Low‐intensity signal ...
Tópico(s): Preterm Birth and Chorioamnionitis
2007 - Wiley | International Journal of Developmental Neuroscience
Takayuki Yamada, Mako Wakabayashi, Abhinav Bhalla, Nitin Chopra, Hirotaka Miyashita, Takahisa Mikami, Hiroki Ueyama, Tomohiro Fujisaki, Yusuke Saigusa, Takahiro Yamaji, Kengo Azushima, Shingo Urate, Toru Suzuki, Eriko Abe, Hiromichi Wakui, Kouichi Tamura,
Abstract Background Emerging evidence suggests that sodium-glucose cotransporter-2 (SGLT-2) inhibitors and glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are associated with decreased risk of cardiovascular and renal events in type 2 diabetes mellitus (DM) patients. However, no study to date has compared the effect of SGLT-2 inhibitors with that of GLP-1 RAs in type 2 DM patients with chronic kidney disease (CKD). We herein investigated the benefits of SGLT-2 inhibitors and GLP-1 RAs in CKD patients. ...
Tópico(s): Pancreatic function and diabetes
2021 - BioMed Central | Cardiovascular Diabetology
Asako Mihashi, Hiroshi Tamura, Eriko Sato, Akikazu Matsumoto,
We have synthesized degradable network polymers containing readily labile peroxy bonds as the repeating units in the main chain or as the cross-linking point in the side chain. Poly(2-hydroxyethyl sorbate-alt-O2) was obtained by the radical copolymerization of 2-hydroxyethyl sorbate with oxygen, and then cross-linked using tolylene 2,4-diisocyanate as the cross-linking agent to obtain a new type of degradable gel. We also investigated the cross-linking of conventional polymers by the reaction of ...
Tópico(s): Photopolymerization techniques and applications
2010 - Elsevier BV | Progress in Organic Coatings
Masahiro Yamasaki, Eriko Harada, Yu Tamura, Sue Yee Lim, Tatsuyuki Ohsuga, Nozomu Yokoyama, Keitaro Morishita, Kensuke Nakamura, Hiroshi Ohta, Mitsuyoshi Takiguchi,
Babesia gibsoni is a causative pathogen of canine babesiosis, which is commonly treated with anti-babesial drugs; however, the development of novel, more effective anti-babesial drugs is necessary because the currently used drugs cannot remove the parasites from dogs. Therefore we investigated the anti-babesial effect of amphotericin B (AmB), a membrane-active polyene macrolide antibiotic. The interaction of such compounds with sterols in bilayer cell membranes can lead to cell damage and ultimately ...
Tópico(s): Bird parasitology and diseases
2014 - Elsevier BV | Veterinary Parasitology
Kazuhiko Nakano, Eriko Miyamoto, Kiyoko Tamura, Hirotoshi Nemoto, Kazuyo Fujita, Ryota Nomura, Takashi Ooshima,
There is scant information available regarding the distribution of periodontal bacterial species in children and adolescents over an extended period. The purpose of this study was to compare bacterial profiles in the same individuals over a period of 7 years.Twenty-six children and adolescents from whom dental plaque and saliva specimens were obtained during both the first (1999-2000) and second (2006-2007) periods, were analyzed. Bacterial DNA was extracted from each specimen and the presence of ...
Tópico(s): Dental Health and Care Utilization
2008 - Wiley | Oral Diseases
Takeshi Ichinohe, Izumi Watanabe, Eriko Tao, Satoshi Ito, Akira Kawaguchi, Shinichi Tamura, Hidehiro Takahashi, Hirofumi Sawa, Masami Moriyama, Joe Chiba, Katsuhiro Komase, Yujiro Suzuki, Takeshi Kurata, Tetsutaro Sata, Hideki Hasegawa,
A safe and effective adjuvant is necessary to enhance mucosal immune responses for the development of an inactivated intranasal influenza vaccine. The present study demonstrated the effectiveness of surf clam microparticles (SMP) derived from natural surf clams as an adjuvant for an intranasal influenza vaccine. The adjuvant effect of SMP was examined when co-administered intranasally with inactivated A/PR8 (H1N1) influenza virus hemagglutinin vaccine in BALB/c mice. Administration of the vaccine ...
Tópico(s): Respiratory viral infections research
2006 - Wiley | Journal of Medical Virology
Eriko Nishio, Hiromichi Yoshikawa, Manabu Wakayama, Hiroto Tamura, Shirô Morita, Yoshifumi Tomita,
Topsoil samples were collected from eight golf courses in Yamaguchi Prefecture, Japan, and enrichment cultures were carried out with a basal-salt medium containing 0.2% 4-tert-octylphenol polyethoxylate (OPPEO) as sole carbon source. OPPEO-degrading activity was detected in one of the samples, from which a strain of OPPEO-degrading bacterium was isolated. The isolated bacterium grew on a nutritionally enriched medium (NE medium) containing 0.2% OPPEO as sole carbon source, and accumulated 4-tert-octylphenol ...
Tópico(s): Marine Biology and Environmental Chemistry
2005 - Oxford University Press | Bioscience Biotechnology and Biochemistry
Kenji KATOH, Hiroki Tamura, Eriko Sato, Tatsuro WAKIMOTO,
This study deals with the control of the movement of liquid droplets rolling down an inclined plate based on the differences in the wettability of the plate. We used a photoreactive polymer poly(7-methacryloyloxy coumarin) (PMC) whose molecular structure can be changed reversibly to realize different wettabilities by ultraviolet irradiation. We proposed employing sawtooth patterns at boundaries between areas with different contact angles to control the droplet trajectory. Furthermore, we experimentally ...
Tópico(s): Fluid Dynamics and Heat Transfer
2018 - Springer Science+Business Media | Experiments in Fluids
Hiroomi Tamura, Kazunori Taniguchi, Eriko Hayashi, Yasuko Hiyoshi, Fusako Nagai,
To explore the physiological roles of sulfotransferases (SULTs) in extra-hepatic tissues, we examined the expression of eight SULT genes by reverse transcription (RT)-PCR in human cell lines that were established from various tissues. Expression levels of SULTs were low in neural cell lines such as NB-1 and GI-1, and high in epithelial cell lines, such as Caco-2 and BeWo. SULT1C2 expression was abundant in all cell types, whereas that of SULT1E1, SULT1B1 or SULT2B1 was restricted to a specific cell ...
Tópico(s): Chemical Synthesis and Analysis
2001 - Pharmaceutical Society of Japan | Biological and Pharmaceutical Bulletin
Tomonori Tamura, Motoki Osawa, Eriko Ochiai, Takanori Suzuki, Takashi Nakamura,
The AmpFLSTR Identifiler Kit, comprising 15 autosomal short tandem repeat (STR) loci, is commonly employed in forensic practice for calculating match probabilities and parentage testing. The conventional system exhibits insufficient estimation for kinship analysis such as sibship testing because of shortness of examined loci. This study evaluated the power of the PowerPlex Fusion System, GlobalFiler Kit, and PowerPlex 21 System, which comprise more than 20 autosomal STR loci, to estimate pairwise ...
Tópico(s): Genetic diversity and population structure
2015 - Elsevier BV | Legal Medicine
Naoto Kuroda, Ichiro Yamasaki, Hirofumi Nakayama, Kenji Tamura, Yukio Yamamoto, Eriko Miyazaki, Keishi Naruse, Hiroshi Kiyoku, Makoto Hiroi, Hideaki Enzan,
Signet‐ring cell carcinoma (SRCC) of the prostate is a very rare neoplasm and there have been only 38 cases reported to date. Here the 39th case of prostatic SRCC containing a small amount of neutral mucin, prostatic specific antigen (PSA) and prostatic specific acid phosphatase (PSAP) in the signet‐ring cells is reported. It was also found that some intracytoplasmic lumina were derived from the shallow or deep invagination of luminal membranes of cancer cells that formed the neoplastic glands. Using ...
Tópico(s): Genital Health and Disease
1999 - Wiley | Pathology International
Hiroko Hirawake, Masafumi Taniwaki, Akiko Tamura, Hisako Amino, Eriko Tomitsuka, Kiyoshi Kita,
We have mapped large (cybL) and small (cybS) subunits of cytochrome b in the succinate–ubiquinone oxidoreductase (complex II) of human mitochondria to chromosome 1q21 and 11q23, respectively (H. Hirawake et al., Cytogenet. Cell Genet. 79 (1997) 132–138). In the present study, the human SDHD gene encoding cybS was cloned and characterized. The gene comprises four exons and three introns extending over 19 kb. Sequence analysis of the 5′ promoter region showed several motifs for the binding of transcription ...
Tópico(s): Photosynthetic Processes and Mechanisms
1999 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - Bioenergetics
Miho Ota, Yuko Koshibe, Shinji Higashi, Kiyotaka Nemoto, Eriko Tsukada, Masashi Tamura, Takumi Takahashi, Tetsuaki Arai,
<b><i>Aim:</i></b> Alzheimer’s disease (AD) is the most common age-related neurodegenerative disease and leads to dementia. AD is characterized by progressive declines in memory and, as the disease progresses, language dysfunction. Although it has been reported that AD patients show progressive aphasia, no study has examined the relationship between language functions estimated by the Standard Language Test for Aphasia (SLTA) and brain network connectivity in Japanese AD patients. ...
Tópico(s): Dementia and Cognitive Impairment Research
2020 - Karger Publishers | Dementia and Geriatric Cognitive Disorders
Shinji Miura, Eriko Tomitsuka, Yasutomi Kamei, Tomomi Yamazaki, Yuko Kai, Mayumi Tamura, Kiyoshi Kita, Ichizo Nishino, Osamu Ezaki,
Peroxisome proliferator-activated receptor-γ co-activator-1α (PGC-1α) is a key nuclear receptor co-activator for mitochondrial biogenesis. Here we report that overexpression of PGC-1α in skeletal muscles increased mitochondrial number and caused atrophy of skeletal muscle, especially type 2B fiber-rich muscles (gastrocnemius, quadriceps, and plantaris). Muscle atrophy became evident at 25 weeks of age, and a portion of the muscle was replaced by adipocytes. Mice showed increased energy expenditure ...
Tópico(s): Peroxisome Proliferator-Activated Receptors
2006 - Elsevier BV | American Journal Of Pathology
Hideki Wada, Manabu Ogita, Katsumi Miyauchi, Shuta Tsuboi, Hirokazu Konishi, Jun Shitara, Mitsuhiro Kunimoto, Taketo Sonoda, Takashi Iso, Hideki Ebina, Eriko Aoki, Kenichi Kitamura, Hiroshi Tamura, Satoru Suwa, Hiroyuki Daida,
Tópico(s): Sex and Gender in Healthcare
2016 - Springer Science+Business Media | Cardiovascular Intervention and Therapeutics
Kazuko Hirai, Eriko Takagi, Yoshinobu Okuno, Kumiko Nagata, Toshihide Tamura, Junko Nakayama, Shiva Kumar, Hem N. Sakya, Mathura P. Shrestha,
This study examined the serum status of serum α-tocopherol (Toc), retinol (Ret), and lipids (cholesterol and triglycerides) and the correlations among them in sera of persons aged 10–72 (42 males and 38 females) living in southeastern Nepal. Serum levels of Toc, Ret and cholesterol (Chol) were positively related to age (r=0.47, r=0.55, and r=0.39, p<0.001, respectively). No significant differences were observed between the sexes for average Toc (3.74 and 3.37 μg/ml) and Chol (133 and 128 mg/100 ml) for ...
Tópico(s): Retinoids in leukemia and cellular processes
1993 - Elsevier BV | Nutrition Research
Atsushi Ikai, Eriko Tamura, Masaaki Nishigai,
Abstract— Solubilization of cattle disk membrane in deoxycholate shifted the fluorescence emission maximum from 324 to 331 nm without changing the intensity. Tryptophyl residues are probably located at the hydrophobic interface between rhodopsin and phospholipid. Depletion of deoxycholate concentration from the solubilized disk by Sephacryl 200 column chromatography produced rhodopsin‐phospholipid complexes with different characteristics that are the intermediate stages of membrane formation from ...
Tópico(s): Neuroscience and Neuropharmacology Research
1980 - Wiley | Photochemistry and Photobiology