... Nelson S, Bagby G, Lorent J, Cardinal P, Granados R, Esteban A, LeSaux C, Tuomanen E, Orihuela C and ...
Tópico(s): Cardiac Imaging and Diagnostics
2012 - Lippincott Williams & Wilkins | Circulation Cardiovascular Imaging
Virginia C. Rodríguez‐Cortez, Lucía del Pino Molina, Javier Rodríguez‐Ubreva, Laura Ciudad, David Gómez-Cabrero, Carlos Company, José Urquiza, Jesper Tegnér, Carlos Rodríguez‐Gallego, Eduardo López‐Granados, Esteban Ballestar,
Abstract Common variable immunodeficiency (CVID), the most frequent primary immunodeficiency characterized by loss of B-cell function, depends partly on genetic defects, and epigenetic changes are thought to contribute to its aetiology. Here we perform a high-throughput DNA methylation analysis of this disorder using a pair of CVID-discordant MZ twins and show predominant gain of DNA methylation in CVID B cells with respect to those from the healthy sibling in critical B lymphocyte genes, such as ...
Tópico(s): Blood disorders and treatments
2015 - Nature Portfolio | Nature Communications
Carlos García‐Verdugo, Carlos Granado‐Yela, Esteban Manrique, Rafael Rubio de Casas, Luís Balaguer,
Woody plants, as sessile and long-lived organisms, are expected to have effective mechanisms for dealing with recurrent environmental stresses. In the present study, we hypothesized that phenotypic plasticity (the ability to express alternative phenotypes) and integration (covariation among functionally related traits) are elicited in plants under stressful wind speed conditions. We investigated the within-crown variation of nine vegetative traits of a tree species (Olea europaea subsp. guanchica) ...
Tópico(s): Plant Water Relations and Carbon Dynamics
2009 - Wiley | American Journal of Botany
Virginia C. Rodríguez‐Cortez, Lucía del Pino Molina, Javier Rodríguez‐Ubreva, Eduardo López‐Granados, Esteban Ballestar,
Tópico(s): Blood disorders and treatments
2016 - Springer Science+Business Media | Journal of Clinical Immunology
María Dolores Rubio, José María Arizón del Prado, M. Molina, M. Cárdenas Aranzana, J Segura Saint-Gerons, Amador López Granados, E Rodríguez Esteban, D Mesa Rubio, Elías Romo Peñas, Carmen Segura Saint-Gerons,
Tópico(s): Advanced biosensing and bioanalysis techniques
2003 - Elsevier BV | Transplantation Proceedings
Esther O’Shea, R Granados, B. Moreno Esteban, María Isabel Colado, A.R Green,
The effect of varying the dose and frequency of administration of 3,4-methylenedioxymethamphetamine (MDMA or `ecstasy') on both the acute hyperthermic response and the long term neurodegeneration of 5-hydroxytryptamine (5-HT) nerve terminals in the brain has been studied in Dark Agouti rats. A single injection (4–15 mg/kg i.p.) of MDMA produced immediate dose-related hyperthermia and a dose-related decrease in 5-HT, 5-hydroxyindoleacetic acid (5-HIAA) and [3H]paroxetine binding in regions of the brain ...
Tópico(s): Neurotransmitter Receptor Influence on Behavior
1998 - Elsevier BV | Neuropharmacology
María Isabel Colado, Esther O’Shea, R Granados, B. Moreno Esteban, Alicia Martín, A R Green,
We investigated whether dopamine plays a role in the neurodegeneration of 5‐hydroxytryptamine (5‐HT) nerve endings occurring in Dark Agouti rat brain after 3,4‐methylenedioxymethamphetamine (MDMA or ‘ecstasy’) administration. Haloperidol (2 mg kg −1 i.p.) injected 5 min prior and 55 min post MDMA (15 mg kg −1 i.p.) abolished the acute MDMA‐induced hyperthermia and attenuated the neurotoxic loss of 5‐HT 7 days later. When the rectal temperature of MDMA+haloperidol treated rats was kept elevated, this protective ...
Tópico(s): Psychedelics and Drug Studies
1999 - Wiley | British Journal of Pharmacology
Miguel A Hernandez Bartolome, Sagrario Fuerte Ruíz, Israel Manzanedo, Beatriz Ramos Lojo, Ignacio Rodriguez Prieto, Luis Gimenez Alvira, Rosario Granados Carreño, Manuel Limones Estebán,
The diagnosis of cystadenoma is rare, even more so when located in the extrahepatic bile duct.Unspecific clinical signs may lead this pathology to be misdiagnosed.The need for pathological anatomy in order to distinguish cystadenomas from simple biliary cysts is crucial.The most usual treatment nowadays is resection of the bile duct, together with cholecystectomy and Roux-en-Y reconstruction.
Tópico(s): Hedgehog Signaling Pathway Studies
2009 - Baishideng Publishing Group | World Journal of Gastroenterology
Maria Elena Granados, Alberto Vilagrosa, Esteban Chirino, V. Ramón Vallejo,
Under Mediterranean conditions, drought and fire are prevalent disturbances that play a fundamental role in the distribution, organization and evolution of ecosystems. Reforestation programs were carried out in degraded areas by planting pines. Presently, the spontaneous regeneration of other species is scarce and species diversity is poor. Introducing woody resprouter species under pine forests would increase species diversity and ecosystem resilience to cope with different types of disturbances, ...
Tópico(s): Fire effects on ecosystems
2015 - Elsevier BV | Forest Ecology and Management
Esteban Vega Granados, Leonor Sanginés García, Agapito Gómez Gurrola, Antonio Hernández Ballesteros, Lourdes Solano, Francisco Escalera-Valente, José Lenin Loya-Olguín,
The aim was to evaluate the effect of replacing alfalfa (AA) with Tithonia diversifolia (TD) in sugar cane silage (SCS) based lamb diets, both with or without supplementation with rice polishings (RP), on in vitro digestibility, nitrogen retention and productive performance. The experimental diets (D) contained the following: D1) 68.6 % of SCS and 29.4 % of TD; D2) 63.7 % of SCS and 34.3 % of AA; D3) 46 % of SCS, 22.6 % of TD and 29.4 % of RP; and, D4) 44.1 % of SCS, 24.5 % of AA and 29.4 % of RP. Diets were isoproteinic ...
Tópico(s): Plant and fungal interactions
2019 - National Institute of Research for Forestry, Agricultural and Livestock | Revista Mexicana de Ciencias Pecuarias
Míkel Izquierdo, Javier Ibáñez, Juan José González‐Badillo, Nicholas A. Ratamess, William J. Kraemer, Keijo Häkkinen, HENRI BONNABAU, Cristina Granados, Duncan N. French, Esteban M. Gorostiaga,
This study examined the impact of 4 weeks of either complete cessation of training (DTR) or a tapering period (TAP; short-term reduction of the strength training volume, while the intensity is kept high), subsequent to 16 weeks of periodized heavy resistance training (PRT) on strength/power gains and the underlying physiologic changes in basal circulating anabolic/catabolic hormones in strength-trained athletes. Forty-six physically active men were matched and randomly assigned to a TAP (n = 11), DTR ( ...
Tópico(s): Genetics and Physical Performance
2007 - Lippincott Williams & Wilkins | The Journal of Strength and Conditioning Research
Míkel Izquierdo, Javier Courel‐Ibáñez, Juan José González‐Badillo, Nicholas A. Ratamess, William J. Kraemer, Keijo Häkkinen, Henri Bonnabau, Cristina Granados, Duncan N. French, Esteban M. Gorostiaga,
This study examined the impact of 4 weeks of either complete cessation of training (DTR) or a tapering period (TAP; short-term reduction of the strength training volume, while the intensity is kept high), subsequent to 16 weeks of periodized heavy resistance training (PRT) on strength/power gains and the underlying physiologic changes in basal circulating anabolic/catabolic hormones in strength-trained athletes. Forty-six physically active men were matched and randomly assigned to a TAP (n = 11), DTR ( ...
Tópico(s): Genetics and Physical Performance
2007 - Lippincott Williams & Wilkins | The Journal of Strength and Conditioning Research
Jesús M. Peñalosa, Ramón O. Carpena, Saúl Vázquez, Ramsy Agha, A. Granado, María José Sarro, Elvira Esteban,
The occurrence of many polluted areas as that affected by the accident of the Aznalcóllar pyrite mine has promoted phytoremediation as a technology able to reduce the risk of heavy metal contamination at low cost. White lupin plant has been considered a good candidate for phytoremediation. We studied the capacity of several complexing agents to improve the ability of white lupin for heavy metal phytoremediation in soils with multi-elemental pollution from acid pyritic sludge. Solution–soil interaction ...
Tópico(s): Plant Stress Responses and Tolerance
2007 - Elsevier BV | The Science of The Total Environment
Saúl Vázquez, Ramsy Agha, A. Granado, M. J. Sarro, Elvira Esteban, Jesús M. Peñalosa, Ramón O. Carpena,
Tópico(s): Clay minerals and soil interactions
2006 - Springer Science+Business Media | Water Air & Soil Pollution
María Isabel Colado, Esther O’Shea, B. Moreno Esteban, R Granados, A R Green,
Clomethiazole is an effective neuroprotective agent against the degeneration of 5-HT neurones that follows administration of 3,4-methylenedioxymethamphetamine (MDMA or ‘ecstasy’). Since there is good evidence that free radical formation resulting from auto-oxidation of MDMA metabolites is responsible for the degeneration we have examined whether clomethiazole is a free radical scavenger. MDMA (15 mg/kg i.p.) increased the formation of 2,3- and 2,5-dihydroxybenzoic acids (2,3-DHBA and 2,5-DHBA) from ...
Tópico(s): Cannabis and Cannabinoid Research
1999 - Elsevier BV | Neuropharmacology
María Isabel Colado, R Granados, Esther O’Shea, B. Moreno Esteban, A R Green,
The immediate effect of administration of 3,4‐methylenedioxymethamphetamine (MDMA or ‘ecstasy’) on rectal temperature and the effect of putative neuroprotective agents on this change has been examined in rats. The influence of the temperature changes on the long term MDMA‐induced neurodegeneration of cerebral 5‐hydroxytryptamine (5‐HT) nerve terminals was also examined. The novel low affinity N‐methyl‐ D ‐aspartate (NMDA) receptor channel blocker AR‐R15896AR (20 mg kg −1 , i.p.) given 5 min before and 55 ...
Tópico(s): Psychedelics and Drug Studies
1998 - Wiley | British Journal of Pharmacology
María Isabel Colado, Raquel Granados, Esther O’Shea, B. Moreno Esteban, A. Richard Green,
Abstract: Administration of a single dose of the recreationally used drug 3, 4‐methylenedioxyethamphetamine (MDEA or “eve”) to Dark Agouti rats resulted in an acute dose‐dependent hyperthermic response. The peak effect and duration of hyperthermia of a dose of MDEA of 35 mg/kg intraperitoneally was similar to a dose of 3, 4‐methylenedioxymetham‐phetamine (MDMA or “ecstasy”) of 15 mg/kg intraperitoneally. Seven days later this dose of MDMA produced a marked (50%) loss of 5‐HT and its metabolite 5‐HIAA ...
Tópico(s): Psychedelics and Drug Studies
1999 - Wiley | Pharmacology & Toxicology
José María Arizón del Prado, M.D. Rubio, M. Cárdenas Aranzana, M. Molina, J Segura Saint-Gerons, Amador López Granados, E Rodríguez Esteban, Martín Ruiz Ortiz, Elías Romo Peñas, Ignacio Muñoz Carvajal, J.R González Rodrı́guez, Carmen Segura Saint-Gerons, Federico Vallés Belsúe, Manuel Concha Ruiz,
The aim of this study was to evaluate cyclosporine (CyA) absorption profiles in heart transplantation to establish the most adequate monitoring strategy and determine the optimal therapeutic range for AUC(0-4) or C2 levels. A total of 22 full pharmacokinetic studies were performed at steady-state in 22 adult heart transplant recipients (18 men, 4 women). Twelve studies were performed during the first month posttransplant (group I), and 10 studies were done after 1 month (group II). In 9 outpatients ...
Tópico(s): Renal Transplantation Outcomes and Treatments
2003 - Elsevier BV | Transplantation Proceedings
Javier Salinas-Luna, Fermı́n Granados-Agustı́n, Alejandro Cornejo-Rodrı́guez, Estebán Luna, Juan Jaime Sánchez-Escobar, Juan Manuel Hernández-Cid,
We present a new method for testing an optical surface. It uses the Ronchi test with variable-frequency rulings and a liquid-crystal display. The rulings can be formed by substructuring the spacing of a Ronchi ruling or combining several classical Ronchi rulings in a single variable-frequency ruling. This change allows us to observe smaller defects on the surface, because it enlarges the spatial-frequency domain of the ruling, and a larger dynamic range of detection of the Ronchi test can be obtained ...
Tópico(s): Industrial Vision Systems and Defect Detection
2009 - SPIE | Optical Engineering
E. Granado, W. Colmenares, Miguel Strefezza, Alfonso de Esteban Alonso,
Abstract This paper describes a web‐based virtual laboratory that improves the automatic control teaching of undergraduate courses. This is achieved by optimizing the time the students spend in the real laboratory. The virtual world or three‐dimensional scenes of real laboratory plants gives the students the opportunity to “learning by doing” through web‐based systems at the location they want, and at the time they like. This virtual laboratory gives the students the tools to be more prepared and ...
Tópico(s): Advanced MEMS and NEMS Technologies
2007 - Wiley | Computer Applications in Engineering Education
Henar Hernando, Claire Shannon‐Lowe, Abul Bashar Mir Md. Khademul Islam, Fátima Al‐Shahrour, Javier Rodríguez‐Ubreva, Virginia C. Rodríguez‐Cortez, Biola M. Javierre, Cristina Mangas, Agustín F. Fernández, Maribel Parra, Henri‐Jacques Delecluse, Manel Esteller, Eduardo López‐Granados, Mario F. Fraga, Núria López-Bigas, Esteban Ballestar,
Epstein-Barr virus (EBV) infection is a well characterized etiopathogenic factor for a variety of immune-related conditions, including lymphomas, lymphoproliferative disorders and autoimmune diseases. EBV-mediated transformation of resting B cells to proliferating lymphoblastoid cells occurs in early stages of infection and is an excellent model for investigating the mechanisms associated with acquisition of unlimited growth.We investigated the effects of experimental EBV infection of B cells on ...
Tópico(s): Cytomegalovirus and herpesvirus research
2013 - BioMed Central | Genome biology
M.L. García de Paredes, F. del Moral González, Purificación Martínez del Prado, J.L. Martí Ciriquián, Santos Enrech Francés, Manuel Cobo, Emilio Esteban, A.L. Ortega Granados, M. Majem Tarruella, José David Cumplido Burón, A. Gascó Hernández, Elena Miranda, Jorge Pinheiro Santos, F.J. de Castro Carpeño,
Tópico(s): Cancer Treatment and Pharmacology
2010 - Elsevier BV | Annals of Oncology
Esteban M. Gorostiaga, Cristina Granados, Javier Courel‐Ibáñez, Juan José González‐Badillo, Míkel Izquierdo,
Fifteen elite male handball players were studied to examine the effects of an entire season of play on physical fitness and throwing velocity.One repetition maximal bench press (1RMBP), jumping explosive strength, power-load relationship of the leg and arm extensor muscles, 5- and 15-m sprint running time, endurance running, and handball throwing velocity (standing and three-step running throw) were assessed on four times (T1, T2, T3, and T4), during a 45-wk season. Individual volumes and intensities ...
Tópico(s): Sports injuries and prevention
2006 - Lippincott Williams & Wilkins | Medicine & Science in Sports & Exercise
José A. López-Salcedo, Esteban Gutiérrez, Gonzalo Seco‐Granados, A. Lee Swindlehurst,
This paper presents a unified framework for the formulation of synchronization algorithms dealing with the general class of Filter-Bank Multi-Carrier (FBMC) communication signals. This is a wide family of signaling formats that includes Orthogonal Frequency Division Multiplexing (OFDM), for instance, as just one of many particular cases. One of the main contributions of this work is the proposal of a novel matrix signal model for so-called flexible FBMC signals, in which no restrictions are imposed ...
Tópico(s): Wireless Communication Networks Research
2012 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Signal Processing
Kuauhyama Luna‐Ortiz, Jaime Esteban Navarrete‐Alemán, Martín Granados‐García, Ángel Herrera‐Gómez,
To describe clinical and demographic characteristics of the parapharyngeal space tumors and assess surgical approaches used to treat them at our institution.A retrospective and descriptive study of the parapharyngeal space tumors, excluding paragangliomas, treated from June 1991 to October 2002 in a cancer center. The study population included 21 patients, 8 men and 13 women, average age of 41 years (range, 20 to 70 years). Fine needle biopsy was done in 5 (24%) patients. Computed tomography (CT) was ...
Tópico(s): Ear and Head Tumors
2005 - Wiley | Otolaryngology
Esteban M. Gorostiaga, Cristina Granados, Javier Courel‐Ibáñez, Míkel Izquierdo,
This study compared physical characteristics (body height, body mass [BM], body fat [BF], and free fatty mass [FFM]), one repetition maximum bench-press (1RM (BP)), jumping explosive strength (VJ), handball throwing velocity, power-load relationship of the leg and arm extensor muscles, 5- and 15-m sprint running time, and running endurance in two handball male teams: elite team, one of the world's leading teams (EM, n = 15) and amateur team, playing in the Spanish National Second Division (AM, n = 15). EM had ...
Tópico(s): Lower Extremity Biomechanics and Pathologies
2005 - Thieme Medical Publishers (Germany) | International Journal of Sports Medicine
Jordane Gavinet, Alberto Vilagrosa, Esteban Chirino, Maria Elena Granados, V. Ramón Vallejo, Bernard Prévosto,
Aleppo pine stands can be made more resilient to disturbances such as forest fires, by introducing native and resprouting hardwood species. Pine density impacts seedling establishment by modifying resource availability and abiotic stress. Under Mediterranean conditions, moderate thinning (15–20 m 2 /ha) was the most effective in promoting the establishment and growth of a number of hardwood species. Developing silvicultural methods to help Mediterranean forests adapt to climate change is of high importance. ...
Tópico(s): Tree-ring climate responses
2015 - Springer Science+Business Media | Annals of Forest Science
Hilda Carrillo-Meléndrez, Esteban Ortega-Hernández, Julio Granados, Sara Arroyo, Rodrigo Barquera, Roberto Arenas,
<b><i>Background:</i></b> Patients with nail psoriasis have an increased risk of onychomycosis. Previous studies suggest it may be due to structural changes of the nails. However, a genetic predisposition seems to be also at play. <b><i>Objective:</i></b> To determine a genetic susceptibility for onychomycosis in nails with changes of psoriasis. <b><i>Methods:</i></b> This is a prospective case-control study of patients with suggestive ...
Tópico(s): Dermatology and Skin Diseases
2016 - | Skin Appendage Disorders
Lucía del Pino Molina, Javier Rodríguez‐Ubreva, Juan Manuel Torres, María Coronel-Díaz, Marta Kulis, José I. Martín‐Subero, Mirjam van der Burg, Esteban Ballestar, Eduardo López‐Granados,
Common Variable Immunodeficiency (CVID) is characterized by impaired antibody production and poor terminal differentiation of the B cell compartment, yet its pathogenesis is still poorly understood. We first reported the occurrence of epigenetic alterations in CVID by high-throughput methylation analysis in CVID-discordant monozygotic twins. Data from a recent whole DNA methylome analysis throughout different stages of normal B cell differentiation allowed us to design a new experimental approach. ...
Tópico(s): T-cell and B-cell Immunology
2019 - Frontiers Media | Frontiers in Immunology
Michaël Sicard, María José Granados-Muñoz, Lucas Alados‐Arboledas, Rubén Barragán, Andrés Esteban Bedoya-Velásquez, José Antonio Benavent-Oltra, Daniele Bortoli, Adolfo Comero︠n, Carmen Córdoba‐Jabonero, María João Costa, Ana del Águila, Alfonso Fernández, Juan Luís Guerrero-Rascado, Oriol Jorba, Francisco Molero, Constantino Muñoz-Porcar, Pablo Ortiz-Amezcua, Nikolaos Papagiannopoulos, Miguel Potes, Manuel Pujadas, Francesc Rocadenbosch, Alejandro Rodríguez-Gómez, Roberto Román, Rui Salgado, Vanda Salgueiro, Yolanda Solá, Margarita Yela,
During the 2017 record-breaking burning season in Canada / United States, intense wild fires raged during the first week of September in the Pacific northwestern region (British Columbia, Alberta, Washington, Oregon, Idaho, Montana and northern California) burning mostly temperate coniferous forests. The heavy loads of smoke particles emitted in the atmosphere reached the Iberian Peninsula (IP) a few days later on 7 and 8 September. Satellite imagery allows to identify two main smoke clouds emitted ...
Tópico(s): Fire effects on ecosystems
2019 - Elsevier BV | Remote Sensing of Environment