Clara Viana Ballester, Benjamı́n Sarriá, Eduardo García‐Granero, Esteban J. Morcillo, Salvador Lledó, Julio Cortijo,
Abstract Background Hypertonicity of the internal anal sphincter (IAS) appears to be involved in the pathogenesis of anal fissure. The relaxant effects of sildenafil, a selective phosphodiesterase 5 (PDE5) inhibitor, on isolated human IAS were investigated. Methods The efficacy (maximal effect, Emax) and potency (−log IC50, where IC50 is half-maximal inhibitory concentration) of the PDE5 inhibitors, sildenafil and zaprinast, and of nitric oxide donors, sodium nitroprusside and glyceryl trinitrate, as ...
Tópico(s): Urinary Bladder and Prostate Research
2007 - Oxford University Press | British journal of surgery
Ricardo Granero, Esteban S Poni, Bertha Escobar‐Poni, Judith Escobar,
Violence by young people is one of the most visible forms of violence and contributes greatly to the global burden of premature death, injury and disability. The Global School-based Student Health Survey (GSHS), State of Lara, Venezuela (GSHS-Lara) is a school-based surveillance system. It comprises a repeated, cross-sectional, self-administered survey drawn from a representative sample of 7th to 9th grade students, performed in the school years 2003-2004 (GSHS-Lara 2004) and 2007-2008 (GSHS-Lara 2008). ...
Tópico(s): Child and Adolescent Health
2011 - BioMed Central | Archives of Public Health
Natalia Sancho‐Rodríguez, Francisco Avilés‐Plaza, Esteban Granero-Fernández, Antonio Miguel Hernández-Martínez, María Dolores Albaladejo-Otón, Pedro Martínez-Mernández, Soledad Parra-Pallarés,
The atherogenic lipoprotein phenotype is characterized by an increase in plasma triglycerides, a decrease in high-density lipoprotein cholesterol (HDLc), and the prevalence of small, dense-low density lipoprotein cholesterol (LDLc) particles. The aim of this study was to establish the importance of LDL particle size measurement by gender in a group of patients with Metabolic Syndrome (MS) attending at a Cardiovascular Risk Unit in Primary Care and their classification into phenotypes.One hundred eighty- ...
Tópico(s): Lipoproteins and Cardiovascular Health
2011 - BioMed Central | Lipids in Health and Disease
Cecilia Gómez‐Santos, Juan José Hernández Morante, Francisco Javier Tébar, Esteban Granero, Marta Garaulet,
Summary Objective To analyze the effect in obese pre‐ and postmenopausal women of a daily dose of 100 mg dehydroepiandrosterone‐sulphate (DHEA‐S) provided over a period of 3 months as replacement therapy against metabolic syndrome. Context Although DHEA‐S appears to be effective against certain features of metabolic syndrome, its usefulness against this syndrome as a whole has not been evaluated to date. Design/Patients A randomized, double‐blind placebo‐controlled trial was conducted involving 61 ...
Tópico(s): Ovarian function and disorders
2011 - Wiley | Clinical Endocrinology
F. Javier Sangrós, Jesús Torrecilla, Carolina Giráldez‐García, Lourdes Carrillo, José Mancera, Teresa Mur, Josep Franch‐Nadal, Javier Díez, Albert Goday, Rosario Serrano, Francisco Javier García Soidán, Gabriel Cuatrecasas, Dimas Igual, Ana Hernández Moreno, J. Manuel Millaruelo, Francisco Carramiñana, Manuel Antonio Ruiz, Francisco Carlos Pérez, Yon Iriarte, Ángela Lorenzo, María González, Beatriz Álvarez, Lourdes Barutell, Ma Soledad Mayayo, Mercedes del Castillo, Emma Navarro, Fernando Malo, Ainhoa Cambra, Riánsares López, Mario Gutiérrez, Luisa Gutiérrez Gutiérrez, Carmen Boente, Javier Mediavilla, Luis Prieto, Luis Mendo, Ma José Mansilla, Francisco J. Ortega, Antonia Borras, L. Gabriel Sánchez, Juan Carlos Obaya, Margarita Alonso, Francisco García, Ángela Trinidad Gutiérrez, Ana Hernández, Dulce Suárez, Juan Carlos Álvarez, Isabel Sáenz, F. Javier Martínez, Ana Casorrán, Jazmín Ripoll, Alejandro Salanova, M. Teresa Marín, Félix Gutiérrez, Jaime Innerárity, M. del Mar Álvarez, Sara Artola, Mariana Bedoya, Santiago Póveda, Fernando Álvarez Guisasola, M. Jesús Brito, Rosario Iglesias, Francisca Paniagua, Pedro Nogales, Ángel Gómez, Jóse Félix Rubio, M. Carmen Durán, Julio Sagredo, Ma Teresa Gijón, M. Ángeles Rollán, Pedro P. Pérez, Javier Gamarra, F Carbonell, Luis García-Giralda, Joaquín Antón, Manuel de la Flor, Rosario Martínez, José Luis Pardo, Antonio Ruíz, Raquel Plana, Ramón Macía, Mercè Villaró, Carmen Babace, Jose Torres, Concepción Blanco, Ángeles Jurado, José Luis Fernández Martín, Jorge Navarro, Gloria Sanz, Rafael Colás, Blanca Cordero, Cristina De Castro, Mercedes Ibáñez, Alicia Monzón, Núria Porta, María del Carmen Gómez, Rafael Llanes, Juan José Ramos Rodríguez, Esteban Granero, Manuel Sánchez, Juan Martínez, Patxi Ezkurra, Luis Ávila, Carlos de la Sen, Antonio Rodríguez‐Poncelas, Pilar Buil, Paula Gabriel, Pilar Roura, Eduard Tarragó, Xavier Mundet, Remei Bosch, J. Carles González, Ma Isabel Bobé, Manel Mata‐Cases, Irene Ruíz, Flora López, M Birulés, Oriol Armengol, Rosa Mar de Miguel, Laura Romera, B. Benito, Neus Piulats, Beatriz Bilbeny, Joan Vila, Xavier Cos, Ramón M. Pujol, Mateu Seguí, Carmen Losada, Ana Santiago, Pedro Muñoz, Enrique Regidor,
Algunas medidas antropométricas muestran mayor capacidad que otras para discriminar la presencia de factores de riesgo cardiovascular. Este trabajo estima la magnitud de la asociación de diversos indicadores antropométricos de obesidad con hipertensión, dislipemia y prediabetes (glucemia basal o glucohemoglobina alteradas). Análisis transversal de la información recogida en 2.022 sujetos del estudio PREDAPS (etapa basal). Se definió obesidad general como índice de masa corporal ≥ 30 kg/m2 y obesidad ...
Tópico(s): Obesity, Physical Activity, Diet
2017 - Elsevier BV | Revista Española de Cardiología
F. Javier Sangrós, Jesús Torrecilla, Carolina Giráldez‐García, Lourdes Carrillo, José Mancera, Teresa Mur, Josep Franch‐Nadal, Javier Díez, Albert Goday, Rosario Serrano, Francisco Javier García Soidán, Gabriel Cuatrecasas, Dimas Igual, Ana Hernández Moreno, J. Manuel Millaruelo, Francisco Carramiñana, Manuel Antonio Ruiz, Francisco Carlos Pérez, Yon Iriarte, Ángela Lorenzo, María González, Beatriz Álvarez, Lourdes Barutell, Ma Soledad Mayayo, Mercedes del Castillo, Emma Navarro, Fernando Malo, Ainhoa Cambra, Riánsares López, Mario Gutiérrez, Luisa Gutiérrez Gutiérrez, Carmen Boente, Javier Mediavilla, Luis Prieto, Luis Mendo, Ma José Mansilla, Francisco Javier Medrano Ortega, Antonia Borras, L. Gabriel Sánchez, Juan Carlos Obaya, Margarita Alonso, Francisco García, Ángela Trinidad Gutiérrez, Ana M Guerreiro Hernández, Dulce Suárez, Juan Carlos Álvarez, Isabel Sáenz, F. Javier Martínez, Ana Casorrán, Jazmín Ripoll, Alejandro Salanova, M. Teresa Marín, Félix Gutiérrez, Jaime Innerárity, M. del Mar Álvarez, Sara Artola, Mariana Bedoya, Santiago Póveda, Fernando Álvarez Guisasola, M. Jesús Brito, Rosario Iglesias, Francisca Paniagua, Pedro Nogales, Ángel Gómez, Jóse Félix Rubio, M. Carmen Durán, Julio Sagredo, Ma Teresa Gijón, M. Ángeles Rollán, Pedro P. Pérez, Javier Gamarra, F Carbonell, Luis García-Giralda, Joaquín Antón, Manuel de la Flor, Rosario Martínez, José Luis Pardo, Antonio Ruíz, Raquel Plana, Ramón Macía, Mercè Villaró, Carmen Babace, Jose Torres, Concepción Blanco, Ángeles Jurado, José Luis Fernández Martín, Jorge Navarro, Gloria Sanz, Rafael Colás, Blanca Cordero, Cristina De Castro, Mercedes Ibáñez, Alicia Monzón, Núria Porta, María del Carmen Gómez, Rafael Llanes, Juan José Ramos Rodríguez, Esteban Granero, Manuel Sánchez, Juan Martínez, Patxi Ezkurra, Luis Ávila, Carlos de la Sen, Antonio Rodríguez‐Poncelas, Pilar Buil, Paula Gabriel, Pilar Roura, Eduard Tarragó, Xavier Mundet, Remei Bosch, J. Carles González, Ma Isabel Bobé, Manel Mata‐Cases, Irene Ruíz, Flora López, M Birulés, Oriol Armengol, Rosa Mar de Miguel, Laura Romera, B. Benito, Neus Piulats, Beatriz Bilbeny, Joan Vila, Xavier Cos, Ramón M. Pujol, Mateu Seguí, Carmen Losada, Ana Santiago, Pedro Muñoz, Enrique Regidor,
Some anthropometric measurements show a greater capacity than others to identify the presence of cardiovascular risk factors. This study estimated the magnitude of the association of different anthropometric indicators of obesity with hypertension, dyslipidemia, and prediabetes (altered fasting plasma glucose and/or glycosylated hemoglobin). Cross-sectional analysis of information collected from 2022 participants in the PREDAPS study (baseline phase). General obesity was defined as body mass index ≥ ...
Tópico(s): Bariatric Surgery and Outcomes
2017 - Elsevier BV | Revista Española de Cardiología (English Edition)
Cecilia Gómez‐Santos, Elvira Larqué, Esteban Granero, Juan José Hernández Morante, Marta Garaulet,
DHEA-S treatment is used as an anti-aging and anti-obesity hormone therapy in adults; however, it mechanisms of action are not clearly elucidated. The objective of the present work was to analyze the effect of a replacement therapy, which included a daily single oral dose of DHEA-S for three months, on the composition of human plasma fatty acids (FAs) in obese women. In the first study, a randomized, double-blind, placebo-controlled trial was conducted involving 61 postmenopausal women, who were ...
Tópico(s): Pharmacology and Obesity Treatment
2011 - Elsevier BV | Steroids
Hasmukhlal Dhirajlal Sankalia,
... 10.1016/j.jasrep.2023.104254Juan José García-Granero, Charusmita Gadekar, Irene Esteban, Carla Lancelotti, Marco Madella, P. Ajithprasad What is ...
Tópico(s): Archaeology and ancient environmental studies
1967 - University of Chicago Press | Current Anthropology
Juan José García-Granero, Charusmita Gadekar, Irene Esteban, Carla Lancelotti, Marco Madella, P. Ajithprasad,
Tópico(s): Pacific and Southeast Asian Studies
2015 - Springer Nature | Archaeological and Anthropological Sciences
Carolina Giráldez‐García, Lucía Cea Soriano, Romana Albaladejo, Josep Franch‐Nadal, Manel Mata‐Cases, Javier Díez‐Espino, Sara Artola, Rosario Serrano, Enrique Regidor, Margarita Alonso, Beatriz Álvarez, Fernando Álvarez Guisasola, Juan Carlos Álvarez, Ma del Mar Álvarez, Joaquín Antón, Oriol Armengol, Luis Ávila, Carmen Babace, Lourdes Barutell, Ma Jesús Bedoya, B. Benito, Beatriz Bilbeny, M Birulés, Concepción Blanco, Ma Isabel Bobé, Carmen Boente, Antonia Borras, Remei Bosch, Ma Jesús Brito, Pilar Buil, J José Cabré, Ainoha Cambra, F Carbonell, Francisco Carramiñana, Lourdes Carrillo, Ana Casorrán, Rafael Colás, Blanca Cordero, Xavier Cos, Gabriel Cuatrecasas, Cristina De Castro, Manuel de la Flor, Carlos de la Sen, Rosa Mar de Miguel, Ana Santiago, Mercedes del Castillo, Ma Carmen Durán-Ruiz, Patxi Ezkurra, Paula Gabriel, Javier Gamarra, Francisco García, Luis García-Giralda, Francisco Javier García Soidán, Ma Teresa Gijón, Albert Goday, Ángel Gómez, María del Carmen Gómez, J. Carles González, María González, Esteban Granero, Ángela Trinidad Gutiérrez, Félix Gutiérrez, Luisa Gutiérrez Gutiérrez, Mario Gutiérrez, Ana Ma Hernández, Mercedes Ibáñez, Rosario Iglesias, Dimas Igual, Jaime Innenaraty, Yon Iriarte, Ángeles Jurado, Rafael Llanes, Flora López, Riánsares López, Ángela Lorenzo, Carmen Losada, Ramón Macía, Fernando Malo, José Mancera, Ma José Mansilla, Ma Teresa Marín, José Luis Fernández Martín, F. Javier Martínez, Juan Martínez, Rosario Martínez, Ma Soledad Mayayo, Javier Mediavilla, Luis Mendo, J. Manuel Millaruelo, Alicia Monzón, Ana Hernández Moreno, Pedro Muñoz, Xavier Mundet, Teresa Mur, Emma Navarro, Jorge Navarro, Pedro Nogales, Juan Carlos Obaya, Francisco Javier Medrano Ortega, Francisca Paniagua, José Luis Pardo, Francisco Carlos Pérez, Pedro P. Pérez, Neus Piulats, Raquel Plana, Núria Porta, Santiago Póveda, Luis Prieto, Ramón M. Pujol, Jazmín Ripoll, Antonio Rodríguez‐Poncelas, Juan José Ramos Rodríguez, Ma Angeles Rollán, Laura Romera, Jóse Félix Rubio, Antonio Ruíz, Irene Ruíz, Manuel Antonio Ruiz, Isabel Sáenz, Julio Sagredo, Alejandro Salanova, L. Gabriel Sánchez, Manuel Sánchez, Gloria Sanz, Mateu Seguí, Dulce Suárez, Eduard Tarragó, Jesús Torrecilla, Jose Torres, Merè Villaró, Carmen Yuste,
Abstract Healthy lifestyle interventions and drug therapies are proven to have a positive preventative influence on normal glucose regulation in prediabetes. However, little is known on the specific role that these factors play on reversion to normal glycemia according to type of prediabetes. We used data from the Observational prospective cohort study, The Cohort study in Primary Health Care on the Evolution of Patients with Prediabetes from 2012 to 2015. A total of 1184 individuals aged 30–74 ...
Tópico(s): Diabetes Treatment and Management
2021 - Nature Portfolio | Scientific Reports
Francisca Torres‐Molina, Juan‐Carlos Aristorena, Carmen Garcia‐Carbonell, Luis Granero, Jesús Chesa‐Jiménez, J.M. Plá-Delfina, José Esteban Peris,
Tópico(s): Central Venous Catheters and Hemodialysis
1992 - Springer Science+Business Media | Pharmaceutical Research
Luis Granero, Marti Santiago, Joan Cano, Alberto Machado, José Esteban Peris,
In vivo microdialysis was used to estimate the extracellular concentrations of ceftazidime and ceftriaxone, two expanded-spectrum cephalosporins commonly used in the treatment of bacterial meningitis, in two brain regions (the right corpus striatum and the left lateral ventricle_ of awake, freely moving rats. Antibiotics were administered by constant intravenous infusion at 18 mg/h until steady-state levels were reached. Ceftriaxone levels measured at the steady state in the extracellular space of ...
Tópico(s): Antibiotic Resistance in Bacteria
1995 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
Luis Granero, J Chesa-Jiménez, Francisca Torres‐Molina, José Esteban Peris,
The pharmacokinetics and tissue distribution of ceftazidime (CFT), a third generation cephalosporin antibiotic commonly used in clinical practice, were investigated in rats after intravenous administration of the antibiotic. Studies using intravenous bolus administration were carried out at two dose levels (5 and 20 mg) of the antibiotic. Results of these studies showed a linear disposition of CFT, no differences between the arterial and venous plasma compartments, and linear distribution in all of ...
Tópico(s): Bacterial Infections and Vaccines
1998 - Wiley | Biopharmaceutics & Drug Disposition
Begoña Sánchez Torrejón, Alejandro Granero Andújar, Jesús Esteban Mora,
The main objective of this article is to acquire in-depth knowledge of the training primary education teachers receive regarding transgender identities, as well as the resulting consequences in school realities. A phenomenological qualitative research approach was used to accomplish this purpose. The data were collected using a semi-structured interview technique. The participants were 38 primary education teachers from different public schools in the province of Cádiz, Spain. They acted as key ...
Tópico(s): Gender and Feminist Studies
2023 - Multidisciplinary Digital Publishing Institute | Education Sciences
María Dolores Albaladejo Otón, Juan Gabriel Calle Luna, Esteban Granero Fernández, Antonio Miguel Hernández Martínez, Soledad Parra Pallarés, Pedro Martı́nez Hernández,
los efectos de la rosiglitazona en el perfil lipídico son controvertidos, y se han descrito aumentos en la concentración de colesterol total y del colesterol unido a lipoproteínas de baja densidad (LDL). Nuestro objetivo es evaluar la concentración y el tamaño de las partículas de LDL en un grupo de pacientes con diabetes mellitus tipo 2, a los que se les añadió rosiglitazona a su tratamiento inicial. se estudió a 30 pacientes diagnosticados de diabetes mellitus tipo 2 en tratamiento con antidiabéticos ...
Tópico(s): Diabetes, Cardiovascular Risks, and Lipoproteins
2009 - Elsevier BV | Medicina Clínica
Luis Granero, M J Gimeno, Francisca Torres‐Molina, J Chesa-Jiménez, José Esteban Peris,
The mechanisms of renal excretion of cefadroxil were investigated in conscious rats. The drug was intravenously infused at several infusion rates (0.27, 1.08, 5.40, 12.00, and 31.35 mg/hr), and the total and renal clearances were determined after the steady-state was reached. Renal clearance accounted for approximately 91% of total clearance. Renal clearance of cefadroxil increased from 2.51 +/- 0.39 to 3.57 +/- 0.43 ml/min as the steady-state cefadroxil plasma concentration increased from 1.7 +/- 0.3 to 24. ...
Tópico(s): Phenothiazines and Benzothiazines Synthesis and Activities
1994 - American Society for Pharmacology and Experimental Therapeutics | Drug Metabolism and Disposition
C.L. Ronchera, Tatiana Hernández, José Esteban Peris, Fernando Torres, Luis Granero, N. V. Jiménez, J. M. Plá,
A case report of toxicity following concurrent administration of high-dose methotrexate and amoxycillin is presented. A 16-year-old male patient was administered 10 high-dose methotrexate cycles for treatment of a fully malignant osteogenic sarcoma. Methotrexate was administered at a dosage of 8 g/m2 and infused intravenously over a 6-h period. The patient received pre- and posttreatment hydration and sodium bicarbonate for alkalinization of urine. Calcium folinate rescue was performed when appropriate. ...
Tópico(s): Rheumatoid Arthritis Research and Therapies
1993 - Lippincott Williams & Wilkins | Therapeutic Drug Monitoring
J Chesa-Jiménez, José Esteban Peris, Francisca Torres‐Molina, Luis Granero,
Several studies have been carried out to elucidate the causes of the low oral bioavailability of amoxicillin in rats. The hepatic first-pass effect of the antibiotic was estimated by comparing the area under the plasma drug concentration-versus-time curve from time zero to infinity (AUC0-infinity) obtained after injecting the drug into a mesenteric vein with the AUC0-infinity value obtained after injecting the drug into the jugular vein of conscious rats. No hepatic first-pass effect was detected. ...
Tópico(s): Drug Solubulity and Delivery Systems
1994 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
O Gómez Beltrán, L Roldán Molleja, J I Garrido Pérez, M Medina Martínez, R Granero Cendón, R González de Caldas Marchal, M Rodríguez Salas, J Gilbert Pérez, R M Paredes Esteban,
Lately, there has been an increase in incidence of acute pancreatitis in childhood. Fortunately, 80% of cases are mild and do not require surgical approach. Several etiologic factors have been implicated, such as infections, trauma, congenital anomalies, drugs, biliary diseases. The aim of this study was to assess etiology, clinical features and outcomes of children with acute pancreatitis treated at our center.A retrospective chart review of our cases of acute pancreatitis in patients younger than ...
Tópico(s): Pancreatitis Pathology and Treatment
2003 - Elsevier BV | Journal of Pediatric Surgery
M. C. García‐Carbonell, Luis Granero, Francisca Torres‐Molina, Juan Carlos Aristorena, J Chesa-Jiménez, J.M. Plá-Delfina, José Esteban Peris,
The pharmacokinetics and bioavailability of cefadroxil in the rat were examined after intravenous and oral administration at three doses (2.5, 10, and 15 mg). Cefadroxil disposition kinetics was clearly nonlinear, with an increase in plasma clearance as the dose increased (2.65 +/- 0.55, 3.17 +/- 0.48, and 3.82 +/- 0.39 ml/min for the three doses assayed). This phenomenon was attributed to a saturable renal tubular reabsorption of the antibiotic. After oral administration, the normalized Cmax was lower for the ...
Tópico(s): Protein Interaction Studies and Fluorescence Analysis
1993 - American Society for Pharmacology and Experimental Therapeutics | Drug Metabolism and Disposition
Marjan Manouchehri, Lucía Cea Soriano, Josep Franch‐Nadal, Antonio Ruíz, Albert Goday, Rosa Villanueva, Javier Díez‐Espino, Manel Mata‐Cases, Carolina Giráldez‐García, Enrique Regidor, Jesús Torrecilla, Lourdes Carrillo, José Mancera, Teresa Mur, Rosario Mérida Serrano, Francisco Javier García Soidán, Gabriel Cuatrecasas, Dimas Igual, Ana Hernández Moreno, J. Manuel Millaruelo, Francisco Carramiñana, Manuel Antonio Ruiz, Francisco Carlos Pérez, Yon Iriarte, Ángela Lorenzo, María González, Beatriz Álvarez, Lourdes Barutell, Ma Soledad Mayayo, Mercedes del Castillo, Emma Navarro, Fernando Malo, Ainoha Cambra, Rosa Magallón-Botaya, Riánsares López, Mario Gutiérrez, Luisa Gutiérrez Gutiérrez, Carmen Boente, Javier Mediavilla, Luis Prieto, Luis Mendo, Ma José Mansilla, Francisco Javier Medrano Ortega, Antonia Borras, L. Gabriel Sánchez, Juan Carlos Obaya, Margarita Alonso, Francisco García, Ángela Trinidad Gutiérrez, Ana Ma Hernández, Dulce Suárez, Juan Carlos Álvarez, Isabel Sáenz, F. Javier Martínez, Ana Casorrán, Jazmín Ripoll, Alejandro Salanova, Ma Teresa Marín, Félix Gutiérrez, Jaime Innenaraty, Ma del Mar Álvarez, Sara Artola, Ma Jesús Bedoya, Santiago Póveda, Fernando Álvarez Guisasola, Ma Jesús Brito, Rosario Iglesias, Francisca Paniagua, Pedro Nogales, Ángel Gómez, Jóse Félix Rubio, Ma Carmen Durán-Ruiz, Julio Sagredo, Ma Teresa Gijón, Ma Angeles Rollán, Pedro P. Pérez, Javier Gamarra, F Carbonell, Luis García-Giralda, Joaquín Antón, Manuel de la Flor, Rosario Martínez, José Luis Pardo, Raquel Plana, Ramón Macía, Mercè Villaró, Carmen Babace, Concepción Blanco, Ángeles Jurado, José Luis Fernández Martín, Jorge Navarro, Gloria Sanz, Rafael Colás, Blanca Cordero, Cristina De Castro, Mercedes Ibáñez, Alicia Monzón, Núria Porta, María del Carmen Gómez, Rafael Llanes, Juan José Ramos Rodríguez, Esteban Granero, Manuel Sánchez, Juan Martínez, Patxi Ezkurra, Luis Ávila, Carlos de la Sen, Antonio Rodríguez‐Poncelas, Pilar Buil, Paula Gabriel, Pilar Roura, Eduard Tarragó, Xavier Mundet, Remei Bosch, J. Carles González, Ma Isabel Bobé, Irene Ruíz, Flora López, Ana Martínez Martínez, M Birulés, Oriol Armengol, Rosa De MarMiguel, Laura Romera, B. Benito, Neus Piulats, Beatriz Bilbeny, Joan Vila, Xavier Cos, Ramón M. Pujol, Mateu Seguí, Carmen Losada, A. De MaríaSantiago, Pedro Muñoz,
Abstract Prediabetes and not just diabetes can cause kidney damage. This study assess the association of prediabetes with development of impaired renal function (IRF). We used data from PREDAPS prospective study a cohort of 1072 subjects with prediabetes and another cohort of 772 subjects without prediabetes were follow-up from 2012 to 2017. Prediabetes was defined according to American Association of Diabetes criteria. IRF was defined as having a glomerular filtration rate < 60 mL/min/1.73 m 2 . Incidence ...
Tópico(s): Diabetes Treatment and Management
2022 - Nature Portfolio | Scientific Reports
Celia Martí‐García, Alba Fernández‐Férez, Cayetano Fernández‐Sola, Rocío Pérez‐Rodríguez, Ana Alejandra Esteban‐Burgos, José Manuel Hernández‐Padilla, José Granero‐Molina,
To explore and understand the experiences of patients with advanced illness in relation to dignity during end-of-life care in emergency departments.Qualitative study based on Gadamer's hermeneutics.Between September 2019 and February 2020, 16 in-depth interviews were carried out with advanced illness patients who attended emergency departments. The participants were informed priorly and signed informed consent. The data were analysed using an inductive strategy for finding emerging themes. The Consolidated ...
Tópico(s): Grief, Bereavement, and Mental Health
2022 - Wiley | Journal of Advanced Nursing
M J Gimeno, Márcio Martinez, Luis Granero, Francisca Torres‐Molina, José Esteban Peris,
Tópico(s): Receptor Mechanisms and Signaling
1996 - American Society for Pharmacology and Experimental Therapeutics | Drug Metabolism and Disposition
Francisca Torres‐Molina, José Esteban Peris, M. C. García‐Carbonell, Juan Carlos Aristorena, Luis Granero, J.M. Plá-Delfina,
Abstract Several features of amoxycillin pharmacokinetics in man are not well known in spite of the extensive clinical use of the antibiotic. In this paper it is demonstrated that amoxycillin disposition kinetics in rats is clearly nonlinear, and that this may be due mainly to its elimination mechanisms. At different intravenous bolus dose levels, and in steady‐state perfusion studies, the most striking feature is an increased renal clearance as dose increases (from 3·5 to 7·0 mg kg −1 for intravenous ...
Tópico(s): Drug Transport and Resistance Mechanisms
1992 - Wiley | Biopharmaceutics & Drug Disposition
Cristina Ballester, Benjamı́n Sarriá, Eduardo García‐Granero, Manuel Mata, Javier Milara, Esteban J. Morcillo, Salvador Lledó, Julio Cortijo,
In this study, responses of β3-adrenoceptor agonists were examined on human isolated internal anal sphincter (IAS) in order to explore their relaxant effects on hypertonicity of IAS. The relaxant efficacy (Emax) and potency (− logIC50) of BRL37344 and SR58611A, β3-adrenoceptor agonists, were examined in contracted IAS muscle strips. The presence of β3-adrenoceptors, and changes in intracellular calcium and cyclic nucleotide levels in IAS muscle were tested by Western blotting, epifluorescence microscopy ...
Tópico(s): Urinary Bladder and Prostate Research
2010 - Elsevier BV | Life Sciences
Verónica Montiel, Emma Muiños‐López, Froilán Granero‐Moltó, M. Alegre Esteban, Felipe Prósper, Ana Pérez Ruiz, Juan Pons‐Villanueva,
Introduction: Atrophy, fatty infiltration and fibrosis are irreversible changes of the muscle after chronic retraction of a torn tendon.These changes result in further loss of function and are prognostic factors for worse clinical outcomes after surgical repair, making such approach ineffective.Currently, there is no clinical treatment to reverse this degenerative condition.This review addresses the findings of experimental studies in the context of the molecular regulation and the cellular origin ...
Tópico(s): Orthopedic Surgery and Rehabilitation
2019 - | Muscles Ligaments and Tendons Journal
Juan Gabriel Calle Luna, Miguel Boronat García, María Dolores Albaladejo Otón, Esteban Granero Fernández, Antonio Miguel Hernández Martínez, Soledad Parra Pallarés,
Desde que el NCEP ATP III (National Cholesterol Education Program. Adult Treatment Panel III) aceptó el predominio de partículas LDL (low density lipoproteins 'lipoproteínas de baja densidad') pequeñas y densas como factor de riesgo emergente de desarrollo de enfermedad cardiovascular, el interés por los métodos para fraccionar las LDL ha aumentado. Por eso, el presente trabajo pretende valorar la utilidad de un sistema de electroforesis en gel de poliacrilamida (Lipoprint®) para separar LDL en nuestra ...
Tópico(s): Blood properties and coagulation
2009 - Elsevier BV | Revista del Laboratorio Clínico
Laura Bravo, Joana F F Simoes, Victor Roth Cardoso, Adewale Adisa, María Lorena Aguilera, Alexis Arnaud, Bruce Biccard, José Andrés Calvache, Saisakul Chernbumroong, Muhammed Elhadi, Dhruva Ghosh, Rohan R Gujjuri, Ewen M. Harrison, Michael Ho, Veeru Kasivisvanathan, Omar Kouli, Hans Lederhuber, Elizabeth Li, Markus Löffler, Arda Işık, Hani J. Marcus, Janet Martin, Kenneth A McLean, Ana Minaya‐Bravo, María Marta Modolo, Dmitri Nepogodiev, Gianluca Pellino, Maria Picciochi, Peter Pockney, Gabriëlle H. van Ramshorst, Aya Riad, Raza Sayyed, Malin Sund, Georgios V. Gkoutos, Aneel Bhangu, James C Glasbey, Laura Bravo, Vasco Cardoso, James Glasbey, S Chernbumroong, Dmitri Nepogodiev, JFF Simoes, Kenneth A McLean, Aneel Bhangu, Georgios V. Gkoutos, Bryar Kadir, Othman Omar, Elliot John Revell, Michael Bahrami‐Hessari, Waheed‐Ul‐Rahman Ahmed, Leah Argus, Alasdair Ball, Aneel Bhangu, Edward Bywater, Ruth Blanco‐Colino, Amanpreet Brar, Daoud Chaudhry, Brett E Dawson, Ignacio Durán, Muhammed Elhadi, James C Glasbey, Rohan R Gujjuri, Conor S Jones, Ewen M. Harrison, Sivesh K. Kamarajah, James M Keatley, Samuel Lawday, Elizabeth Li, Harvinder Mann, Ella J Marson, Kenneth A McLean, Dmitri Nepogodiev, Lisa Norman, Riinu Ots, Oumaima Outani, Maria Picciochi, Irène Santos, Caitlin Shaw, Elliott H Taylor, Isobel M Trout, Chris Varghese, Mary L Venn, William Xu, Irida Dajti, Arben Gjata, Salah Eddine Oussama Kacimi, Luis Boccalatte, Daniel Cox, Peter Pockney, Felix Aigner, Irmgard Kronberger, Elgun Samadov, Amer Alderazi, Greg Padmore, Gabriëlle H. van Ramshorst, Ismaïl Lawani, Anis Cerovac, Samir Delibegović, Glauco Baiocchi, Gustavo Mendonça Ataíde Gomes, Igor Lima Buarque, Muhammad Gohar, Mihail Slavchev, Chukwuemeka Nwegbu, Arnav Agarwal, Amanpreet Brar, Janet Martin, Joshua S Ng-Kamstra, Maricarmen Olivos, Wenhui Lou, Donglin Ren, Jose Andres Calvache, C. Perez, Ana Đanić Hadžibegović, Tomislav Kopjar, Jakov Mihanović, Pablo Mijahil Avilés Jiménez, Nikolaos Gouvas, Jaroslav Klát, René Novysedlák, Nicolas Amisi, Peter Christensen, Alaa El‐Hussuna, Sylvia Batista, Eddy Lincango-Naranjo, Sameh Hany Emile, Danilo Alfonso Arévalo Sandoval, Hailu Tamiru Dhufera, Samuel Hailu, Mengistu G Mengesha, Joonas H. Kauppila, Alexis Arnaud, Zaza Demetrashvili, Markus Albertsmeier, Hans Lederhuber, Markus Löffler, Daniel Kwesi Acquah, Bernard Ofori, Stephen Tabiri, Symeon Metallidis, Georgios Tsoulfas, Maria‐Lorena Aguilera‐Arevalo, Gustavo Recinos, Tamás Mersich, Dániel Wettstein, Dhruva Ghosh, Gabriele Kembuan, Peiman Brouki Milan, Mohammad Hossein Khosravi, Masoud Mozafari, Ahmed Hilmi, Helen Mohan, Oded Zmora, Gaetano Gallo, Francesco Pata, Gianluca Pellino, Yuki Fujimoto, Naoto Kuroda, Sohei Satoi, Mohamad K. Abou Chaar, Faris Ayasra, Ildar Fakhradiyev, Intisar Hisham Said Hamdun, Jang Jin-Young, Mohammad H. Jamal, Lina Karout, Muhammed Elhadi, Aistė Gulla, Fanjandrainy Rasoaherinomenjanahary, Luc Hervé Samison, April Camilla Roslani, Iran Irani Durán Sánchez, Diana Samantha Gonzalez, Laura Martínez, María José Martínez, Alejandra Nayen, Antonio Ramos‐De la Medina, Jade Nunez, Oumaima Outani, Pueya Rashid Nashidengo, Ashish Lal Shrestha, Pascal Jonker, Schelto Kruijff, Milou E. Noltes, Pieter J. Steinkamp, Chris Varghese, Deborah Wright, LO Abdur-Rahman, Adesoji Ademuyiwa, Adewale Adisa, Babatunde Osinaike, Justina O. Seyi‐Olajide, Omolara Williams, Emmanuel Williams, Sofija Pejkova, Zainab Al Balushi, Ahmad Uzair Qureshi, Raza Sayyed, Mohamed Mohsen, Sadi A. Abukhalaf, Moisés Cukier, Hugo Gomez-Fernandez, Sharon Wing Lam Yip, Ximena Paola Vasquez Ojeda, Marie Dione Sacdalan, Piotr Major, José Azevedo, Miguel F Cunha, Ahmad Zarour, Eduard-Alexandru Bonci, Ionut Negoi, Sergey Efetov, V. S. Kochetkov, Andrey Litvin, JC Allen Ingabire, Georges Bucyibaruta, Faustin Ntirenganya, Sosthene Habumuremyi, Alphonsine Imanishimwe, Hôtel Dieu, Emmanuel Munyaneza, Isaie Ncogoza, Ehab Alameer, Abdourahmane Ndong, Dejan Radenković, Min Hoe Chew, Frederick H. Koh, James Chi‐Yong Ngu, Arpád Panyko, Uroš Bele, Jurij Aleš Košir, H. Daoud, Ruth Blanco‐Colino, Ana Minaya‐Bravo, Umesh Jayarajah, Dakshitha Wickramasinghe, Mohammed Elmujtba Adam Essa Adam, Martin Rutegård, Malin Sund, Michel Adamina, Eleftherios Gialamas, Karoline Horisberger, Muhammad Alshaar, Varut Lohsiriwat, Shane Charles, Arda Işık, Sezai Leventoğlu, Hervé Monka Lekuya, Herman Lule, Slava Kopetskyi, Hamoud Faraj Freej Alsaadi, Sattar Alshryda, Osaid Alser, Brittany Bankhead-Kendall, Kerry Breen, Haytham M.A. Kaafarani, Hassan Mashbari, Fernando Bonilla Cal, Hamza Al-Naggar, Mayaba Maimbo, Dennis Mazingi, Tom Abbott, Michel Adamina, Melika Akhbari, Shivam Bhanderi, Bruce Biccard, Sohini Chakrabortee, Ainhoa Costas‐Chavarri, Andreas K Demetriades, Anant Desai, Salomone Di Saverio, Thomas M Drake, John Edwards, Jonathan Evans, Marco Fiore, Samuel Ford, Christina Fotopoulou, Alexander J. Fowler, Kaori Futaba, Ian Ganly, Hannah James, Ewen A. Griffiths, Peter J. Hutchinson, Gabriella Hyman, Joseph Incorvia, Ritu Jain, Michael D. Jenkinson, Tabassum Khan, Stephen R Knight, Angelos G. Kolias, Søren Kudsk‐Iversen, Tsun Yu Kwan, Elaine Leung, Julio Mayol, S McKay, John G. Meara,
Pulmonary complications are the most common cause of death after surgery. This study aimed to derive and externally validate a novel prognostic model that can be used before elective surgery to estimate the risk of postoperative pulmonary complications and to support resource allocation and prioritisation during pandemic recovery. Data from an international, prospective cohort study were used to develop a novel prognostic risk model for pulmonary complications after elective surgery in adult patients ( ...
Elsevier BV
Gennaro De Pascale, Massimo Antonelli, Mieke Deschepper, Kostoula Arvaniti, Koen Blot, Ben Creagh Brown, Dylan W. de Lange, Jan J. De Waele, Yalım Dikmen, George Dimοpoulos, Christian Eckmann, Guy François, Massimo Girardis, Despoina Koulenti, Sonia Labeau, Jeffrey Lipman, Fernando Lipovetsky, Emilio Maseda, Philippe Montravers, Adam Mikstacki, José Artur Paiva, Cecilia Pereyra, Jordi Rello, Jean‐François Timsit, Dirk Vogelaers, Stijn Blot, Amin Lamrous, Cecilia Pereyra, Fernando Lipovestky, Despoina Koulenti, Jan J. De Waele, João Rezende-Neto, Tomáš Vymazal, Hans Fjeldsoee-Nielsen, Philippe Montravers, Matthias Kott, Kostoula Arvaniti, Yash Javeri, Massimo Girardis, Sharon Einav, Dylan W. de Lange, Luis Daniel Umezawa Makikado, Adam Mikstacki, José Artur Paiva, Dana Tomescu, А. И. Грицан, Bojan Jovanović, Kumaresh Venkatesan, Tomislav Mirković, Emilio Maseda, Yalım Dikmen, Ben Creagh‐Brown, Monica Emmerich, Mariana Canale, Lorena Silvina Dietz, Santiago Ilutovich, John Thomas Sanchez Miñope, Ramona Baldomera Silva, Martin Alexis Montenegro, Patricio Martin, Pablo Saul, Viviana Chediack, Giselle Sutton, Rocio Couce, Carina Balasini, Susana González-Granero, Florencia Maria Lascar, Emiliano Descotte, Natalia Soledad Gumiela, Carina Alejandra Pino, Cristian Cesio, Emanuel Valgolio, Eleonora Cunto, Cecilia Dominguez, Fernando Lipovestky, Nydia Funes Nelson, Esteban Martin Abegao, Cecilia Pereyra, Norberto Christian Pozo, L. Bianchi, Enrique Correger, Maria Laura Pastorino, Erica Aurora Miyazaki, Nicolas Grubissich, Mariel Garcia, Natalia Bonetto, Noelia Elizabeth Quevedo, Cristina Delia Gomez, Felipe Queti, Luis Gonzalez Estevarena, Rubén Fernández, Ignacio Santolaya, Norberto Christian Pozo, Sergio Hugo Grangeat, Juan Doglia, Graciela Zakalik, Carlos A. Pellegrini, Maria Monserrat Lloria, Mercedes Esteban Chacon, Mariela Fumale, Mariela Leguizamon, Irene Beatriz Hidalgo, Roberto Juli an Tiranti, Paola Capponi, Agustin Tita, Luis Cardonnet, Lisandro Roberto Bettini, Agñel Ramos, Luciano Lovesio, Edith Miriam Miranda, Angelica Beatriz Farfan, Carina Tolosa, Lise Segura, Adelina Bellocchio, Brian Alvarez, Adriana Manzur, Rodolfo Lujan, Natalia Fernández, Nahuel Scarone, Alan Zazu, Carina Groh, Jason Fletcher, Julie Smith, Raman Azad, N. Chavan, Mark Kol, Lewis Campbell, Despoina Koulenti, Therese Starr, Brigit Roberts, Bradley Wibrow, Timothy Warhurst, Meher Chinthamuneedi, Bernal Buitrago Ferney, Marc A. Simon, Daniel De Backer, Xavier Wittebole, David De Bels, V. Collin, Karolien Dams, Philippe G. Jorens, Jan J. De Waele, Jasperina Dubois, Jan Gunst, Lionel Haentjens, Nicolas De Schryver, Thierry Dugernier, João Rezende-Neto, Sandro Rizoli, Paul Santillan, Yi Han, Ewelina Biskup, Changjing Qu, Xinyu Li, Tao Yu, Lu Wei-Hua, Daniel Molano-Franco, José D. Rojas, Juan Mauricio Pardo Oviedo, Dario Pinilla, Yenny Cardenas, Édgar Celis, Mario Arias, Anita Vukovic, Maja Vudrag, Matija Belavic, Josip Žunić, Janja Kuharić, Irena Bozanic Kricka, Ina Filipović-Grčić, Boris Tomašević, Melanija Obraz, Bruna Bodulica, Martin Dohnal, Jan Maláska, Milan Kratochvíl, I Satinský, Peter E. H. Schwarz, Zdeněk Kos, Ladislav Blahut, Jan Máca, Marek Protuš, Eva Kieslichová, Louise Gramstrup Nielsen, Birgitte Marianne Krogh, Francisco Rivadeneira, Freddy Alejandro Portillo Morales, José Ferrater Mora, Alexandra Saraguro Orozco, Diego Rolando MorochoTutillo, Nelson Remache Vargas, Estuardo Salgado Yepez, Boris Villamagua, Adel Alsisi, Abdelraouf Fahmy, Hervé Dupont, Sigismond Lasocki, Cathérine Paugam‐Burtz, Arnaud Foucrier, Nica Alexandru, Geneviève Barjon, Jihad Mallat, Guillaume Marcotte, Marc Léone, Gary Duclos, Philippe Burtin, Philippe Montravers, Enora Atchade, Yazine Mahjoub, Benoît Misset, Jean‐François Timsit, Claire Dupuis, Benoît Veber, Matthieu Débarre, Oliver Collange, Julien Pottecher, Stephane Hecketsweiler, Mélanie Fromentin, Antoine Tesnière, Christian Koch, Michael Sander, Matthias Kott, Gunnar Elke, Hermann Wrigge, Philipp Simon, Anthoula Chalkiadaki, Charalampos Tzanidakis, Ioannis Pneumatikos, Eleni Sertaridou, Zafiria Mastora, Ioannis Pantazopoulos, Metaxia Papanikolaou, Theonymfi Papavasilopoulou, John D. Floros, George Dimοpoulos, Chryssa Diakaki, Michail Rallis, Alexandra Paridou, Alexandros Kalogeromitros, Vasiliki Romanou, Charikleia Nikolaou, Katerina Kounougeri, Evdoxia Tsigou, Vasiliki Psallida, Niki Karampela, Konstantinos Mandragos, Eftychia Kontoudaki, Alexandra Pentheroudaki, Christos Farazi-Chongouki, Agathi Karakosta, Isaac Chouris, Vasiliki Radu, Polychronis Malliotakis, Sofia Kokkini, Eliana Charalambous, Aikaterini Kyritsi, Vasilios Koulouras, Γεώργιος Παπαθανάκος, Eva Nagky, Clairi Lampiri, Fotios Tsimpoukas, Ioannis Sarakatsanos, Panagiotis Georgakopoulos, Ifigeneia Ravani, A. Prekates, Konstantinos Sakellaridis, Christos Christopoulos, Efstratia Vrettou, Konstantinos Stokkos, Anastasia Pentari, Kostoula Arvaniti, Kyriaki Marmanidou, C. Kydona, Georgios Tsoumaropoulos, Militisa Bitzani, Paschalina Kontou, Antonios Voudouris, Elli-Nikki Flioni, E. Antypa, Eleftheria Chasou, Souzana Anisoglou, Eirini Papageorgiou, Theoniki Paraforou, Agoritsa Tsioka, Antigoni Karathanou, A. Vakalos, Bhagyesh Shah, Chirag Thakkar, Nikhilesh Jain, Mohan Gurjar, Arvind Baronia, Prachee Sathe, S. Kulkarni, Cherish Paul, John R. Paul, Mansoor Masjedi,
To describe data on epidemiology, microbiology, clinical characteristics and outcome of adult patients admitted in the intensive care unit (ICU) with secondary peritonitis, with special emphasis on antimicrobial therapy and source control. Post hoc analysis of a multicenter observational study (Abdominal Sepsis Study, AbSeS) including 2621 adult ICU patients with intra‐abdominal infection in 306 ICUs from 42 countries. Time-till-source control intervention was calculated as from time of diagnosis ...
Springer Science+Business Media
Renée Onnainty, Esteban M. Schenfeld, Mario A. Quevedo, Mariana A. Fernández, Marcela R. Longhi, Gladys E. Granero,
Hydrochlorothiazide (HCT) is one of the most commonly prescribed antihypertensive drugs. In an attempt to gain an insight into the physicochemical and molecular aspects controlling the complex architecture of native β-cyclodextrin (β-CD) with HCT, we performed multiple-temperature–pH isothermal titration calorimetric measurements of the HCT:β-CD system, together with proton nuclear magnetic resonance spectroscopy (1H NMR), phase solubility analysis, and molecular modeling methods. The AL-type diagrams, ...
Tópico(s): Chemical and Physical Properties in Aqueous Solutions
2012 - American Chemical Society | The Journal of Physical Chemistry B