Yoichi Inoue, Etsuko Inoue, Shoji Itakura,
Abstract: A three‐year‐old white‐handed gibbon ( Hylobates lar ) was tested in terms of her ability to follow experimenter‐given directional cues in an object‐choice task. Four conditions were run: the experimenter baited one of two cups and then gave one of the following four directional cues: (a) pointing at the baited cup from a short distance (5 cm); (b) pointing at the target from a long distance (20 cm); (c) orienting body, head, and eyes toward the baited cup; and (d) orienting eyes only toward the ...
Tópico(s): Face Recognition and Perception
2004 - Wiley | Japanese Psychological Research
Kenji Kawakita, Toshiyuki Shichidou, Etsuko Inoue, Tomoyuki Nabeta, Hiroshi Kitakouji, Shigekatsu Aizawa, Atsushi Nishida, Nobuo Yamaguchi, Norihito Takahashi, Tadashi Yano, Syouhachi Tanzawa,
To determine the preventive and curative effects of manual acupuncture on the symptoms of the common cold. Students and staff in five Japanese acupuncture schools (n = 326) were randomly allocated to acupuncture and no-treatment control groups. A specific needling point (Y point) on the neck was used bilaterally. Fine acupuncture needles were gently manipulated for 15 s, evoking de qi sensation. Acupuncture treatments were performed four times during the 2-week experimental period with a 2-week follow- ...
Tópico(s): Traditional Chinese Medicine Studies
2004 - Elsevier BV | Complementary Therapies in Medicine
Hiroyuki Sakata, Kazuma Fujimoto, Ryuichi Iwakiri, Masanobu Mizuguchi, Takanori Koyama, Takahiro Sakai, Etsuko Inoue, Osamu Tokunaga, Yoshinori Shimamoto,
BACKGROUND Adult T-cell leukemia/lymphoma (ATLL) is caused by human T-lymphotropic virus type I. Gastric lesions in ATLL have not been described precisely, whereas the clinical features of ATLL have been well documented. The goal of the present study was to review gastric lesions, including gastric involvement, of patients with ATLL who were admitted to our hospital. METHODS Endoscopic examination of the upper gastrointestinal tract was performed on 76 of 110 patients who were admitted to our hospital ...
Tópico(s): Vector-Borne Animal Diseases
1996 - Wiley | Cancer
Kieko Shirahama, Etsuko Inoue,
The purpose of this study was to explore the concept of spirituality and its expression among persons in a Japanese farming community. It was found that spirituality was described as "living in harmony with nature and surrounding people." Common expressions of this spirituality were through faith and ways of worship, prayer, search for inner peace, hope and thanksgiving, including spiritual well-being. The latter was defined as showing thanks to nature, ancestors, and people; caring for surrounding ...
Tópico(s): Religion, Society, and Development
2001 - Lippincott Williams & Wilkins | Holistic Nursing Practice
Kenji Kawakita, Toshiyuki Shichidou, Etsuko Inoue, Tomoyuki Nabeta, Hiroshi Kitakoji, Shigekatsu Aizawa, Atsushi Nishida, Nobuo Yamaguchi, Norihito Takahashi, Eiji Sumiya, Kaoru Okada, Takashi Umeda, Tadashi Yano, Shouhachi Tanzawa,
We summarize the results from a series of investigations of Japanese style acupuncture and moxibustion therapies on symptoms of the common cold that have been conducted (FTLE 1999–03, supported by the Foundation for Training and Licensure Examination in Anma‐ Massage‐ Acupressure, Acupuncture and Moxibustion). We also discuss the various interventions and concerns that we faced during these investigations. The subjects were students and teachers. The pilot study (FTLE1999) of a two arm (real and non‐ ...
Tópico(s): Traditional Chinese Medicine Studies
2007 - Hindawi Publishing Corporation | Evidence-based Complementary and Alternative Medicine
Maki Deguchi‐Tawarada, Eiji Inoue, Etsuko Takao‐Rikitsu, Marie Inoue, Isao Kitajima, Toshihisa Ohtsuka, Yoshimi Takai,
Abstract CAST is a novel cytomatrix at the active zone (CAZ)‐associated protein. In conventional brain synapses, CAST forms a large molecular complex with other CAZ proteins, including RIM, Munc13‐1, Bassoon, and Piccolo. Here we investigated the distribution of CAST and its structurally related protein, ELKS, in mouse retina. Immunofluorescence analyses revealed that CAST and ELKS showed punctate signals in the outer and inner plexiform layers of the retina that were well‐colocalized with those ...
Tópico(s): Neuroscience and Neuropharmacology Research
2006 - Wiley | The Journal of Comparative Neurology
Maki Deguchi‐Tawarada, Eiji Inoue, Etsuko Takao‐Rikitsu, Marie Inoue, Toshihisa Ohtsuka, Yoshimi Takai,
The cytomatrix at the active zone (CAZ) is thought to define the site of Ca2+-dependent exocytosis of neurotransmitters. We have recently identified a novel CAZ protein from rat brain which we have named CAST (CAZ-associated structural protein). CAST forms a large molecular complex with other CAZ proteins such as Bassoon, RIM1 and Munc13-1, at least through direct binding to RIM1. Here, we have identified a rat protein that is structurally related to CAST and named it CAST2. Subcellular fractionation ...
Tópico(s): Retinal Development and Disorders
2004 - Wiley | Genes to Cells
Masaaki Sawa, Takao Kiyoi, Kiriko Kurokawa, Hiroshi Kumihara, Minoru Yamamoto, Tomohiro Miyasaka, Yasuko Ito, Ryoichi Hirayama, Tomomi Inoue, Yasuyuki Kirii, Eiji Nishiwaki, Hiroshi Ohmoto, Yu Maeda, Etsuko Ishibushi, Yoshimasa Inoue, Kiyoshi Yoshino, Hirosato Kondo,
A series of phosphonamide-based hydroxamate derivatives were synthesized, and the inhibitory activities were evaluated against various metalloproteinases in order to clarify its selectivity profile. Among the four diastereomeric isomers resulting from the chirality at the C-3 and P atoms, the compound with a (R,R)-configuration both at the C-3 position and the phosphorus atom was found to be potently active, while the other diastereomeric isomers were almost inactive. A number of (R,R)-compounds synthesized ...
Tópico(s): Carbohydrate Chemistry and Synthesis
2002 - American Chemical Society | Journal of Medicinal Chemistry
Eiji Inoue, Maki Deguchi‐Tawarada, Etsuko Takao‐Rikitsu, Marie Inoue, Isao Kitajima, Toshihisa Ohtsuka, Yoshimi Takai,
The active zone protein CAST binds directly to the other active zone proteins RIM, Bassoon and Piccolo, and it has been suggested that these protein-protein interactions play an important role in neurotransmitter release. To further elucidate the molecular mechanism, we attempted to examine the function of CAST using PC12 cells as a model system. Although PC12 cells do not express CAST, they do express ELKS, a protein structurally related to CAST. Endogenous and exogenously expressed ELKS, RIM2 ...
Tópico(s): Protein Kinase Regulation and GTPase Signaling
2006 - Wiley | Genes to Cells
Etsuko Nakamura, Akio Inoue, T. Hayashino, Masaki Horie, K. Kousai, T. Fujii, Yuichi Matsuda,
We present results of a survey of Lyman $\alpha$ emitters (LAEs) at $z=6.5$ which is thought to be the final epoch of the cosmic reionization. In a $\approx530$ arcmin$^2$ deep image of the SSA22 field taken through a narrowband filter NB912 installed in the Subaru/Suprime-Cam, we have found only 14 LAE candidates with $L_{\rm Ly\alpha}\ga3\times10^{42}$ erg s$^{-1}$. Even applying the same colour selection criteria, the number density of the LAE candidates is a factor of 3 smaller than that found at the ...
Tópico(s): Astrophysics and Cosmic Phenomena
2011 - Oxford University Press | Monthly Notices of the Royal Astronomical Society
Makoto Nishimura, Yuya Okimura, Hirofumi Fujita, Hiromi Yano, Jintae Lee, Etsuko Suzaki, Masayasu Inoue, Kozo Utsumi, Junichi Sasaki,
Abstract 3‐Nitropropionic acid (3NP) functions as an irreversible inhibitor of succinic acid dehydrogenase (complex II) and induces neuronal disorders in rats similar to those in patients with Huntington's disease. It is well known that L ‐carnitine (LC), a carrier of long chain fatty acid into the mitochondrial matrix, attenuates the neuronal degeneration in 3NP‐treated rats. From these findings it has been suggested that 3NP induces certain neuronal cell death through mitochondrial dysfunction and ...
Tópico(s): Metabolism and Genetic Disorders
2008 - Wiley | Cell Biochemistry and Function
Hiroshi Watarai, Etsuko Sekine, Sayo Inoue, Ryusuke Nakagawa, Tsuneyasu Kaisho, Masaru Taniguchi,
Type I interferons (IFNs) derived from plasmacytoid dendritic cells (PDCs) are critical for antiviral responses; however, the mechanisms underlying their production remain unclear. We have identified a receptor, PDC-TREM, which is associated with Plexin-A1 (PlxnA1) on the PDC cell surface and is preferentially expressed after TLR-stimulation. Limited TLR signals induced PDC-TREM expression but failed to induce IFN-alpha production. However, when coupled with Sema6D, a ligand for Plexin-A1, limited ...
Tópico(s): Inflammasome and immune disorders
2008 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Yoshiharu Taguchi, Shutaro Takashima, Etsuko Sasahara, Hiroshi Inoue, Osamu Ohtani,
The microvasculature in the brain plays a vital role in the maintenance of brain perfusion, and fulfills the dynamic requirements of normal brain functions. It is well known that collateral circulation can be induced by ischemia in cerebral infarctions, but it is not known whether cerebral ischemia affects microvasculatures in the ischemic region. In the present study, we examined quantitatively serial changes in capillaries following bilateral common carotid artery ligation in Wistar rats. After ...
Tópico(s): Biochemical effects in animals
2004 - International Society Histology & Cytology | Archives of Histology and Cytology
Masayoshi Nishiyama, Etsuko Muto, Yuichi Inoue, Toshio Yanagida, Hideo Higuchi,
Tópico(s): Cellular transport and secretion
2001 - Nature Portfolio | Nature Cell Biology
Shunsuke Meshitsuka, Etsuko Yamazaki, Masakatsu Inoue, Hiroshi Hagino, Ryota Teshima, Kichizo Yamamoto,
Tópico(s): Traditional Chinese Medicine Analysis
1999 - Elsevier BV | Clinica Chimica Acta
Hideo Higuchi, Etsuko Muto, Yuichi Inoue, Toshio Yanagida,
To relate transients of force by single kinesin molecules with the elementary steps of the ATPase cycle, we measured the time to force generation by kinesin after photorelease of ATP from caged ATP. Kinesin-coated beads were trapped by an infrared laser and brought onto microtubules fixed to a coverslip. Tension was applied to a kinesin-microtubule rigor complex using the optical trap, and ATP was released by flash photolysis of caged ATP with a UV laser. Kinesin started to generate force and move ...
Tópico(s): Mechanical and Optical Resonators
1997 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Etsuko Hirata, Masayasu Inoue, Yoshimasa Morino,
To elucidate the mechanism of biliary occurrence of gamma-glutamyl transferase [EC 2.3.2.2] and alkaline phosphatase [EC 3.1.3.1], the effect of bile acids on the biliary level of these enzymes was studied in vivo and in vitro. Following intravenous administration of taurocholate, the activities of both enzymes in rat bile increased markedly with a concomitant increase in the excretion of the bile acid. The biliary levels of these enzymes increased to reach a maximum at 10-20 min after administration ...
Tópico(s): Drug Transport and Resistance Mechanisms
1984 - Oxford University Press | The Journal of Biochemistry
Eiji Inoue, Sumiko Mochida, Hiroshi Takagi, Susumu Higa, Maki Deguchi‐Tawarada, Etsuko Takao‐Rikitsu, Marie Inoue, Ikuko Yao, Kosei Takeuchi, Isao Kitajima, Mitsutoshi Setou, Toshihisa Ohtsuka, Yoshimi Takai,
Summary A serine/threonine kinase SAD-1 in C. elegans regulates synapse development. We report here the isolation and characterization of mammalian orthologs of SAD-1, named SAD-A and SAD-B, which are specifically expressed in the brain. SAD-B is associated with synaptic vesicles and, like the active zone proteins CAST and Bassoon, is tightly associated with the presynaptic cytomatrix in nerve terminals. A short conserved region (SCR) in the COOH-terminus is required for the synaptic localization of SAD- ...
Tópico(s): Lipid Membrane Structure and Behavior
2006 - Cell Press | Neuron
Masayasu Inoue, Etsuko Hirata, Yoshimasa Morino, Sumi Nagase, Jayanta Roy Chowdhury, Namita Roy Chowdhury, Irwin M. Arias,
... Mutant Analbuminemic Rats Get access Masayasu INOUE, Masayasu INOUE *Department of Biochemistry, Kumamoto University Medical SchoolHonjo, Kumamoto, Kumamoto 860 Search for other works by this author on: Oxford Academic PubMed Google Scholar Etsuko HIRATA, Etsuko HIRATA *Department of Biochemistry, Kumamoto University ...
Tópico(s): Methemoglobinemia and Tumor Lysis Syndrome
1985 - Oxford University Press | The Journal of Biochemistry
Ayumi Kanazawa, Hideki Hyodoh, Satoshi Watanabe, Marika Fukuda, Miho Baba, Shunichiro Okazaki, Keisuke Mizuo, Etsuko Hayashi, Hiromasa Inoue,
An 80-year-old female was transferred to the hospital due to a traffic accident. Multiple cranial bone fractures with intracranial hemorrhage and intracranial air were detected. Despite treatment, the patient died after 6h. Twenty-one hours after the patient died, her whole body was scanned by postmortem CT, and a region of high density was detected within the left putamen. The autopsy revealed a cerebral contusion and multiple skull base fractures. Moreover, superabsorbent polymers (SAPs) were found ...
Tópico(s): Forensic Entomology and Diptera Studies
2014 - Elsevier BV | Legal Medicine
Xian‐Yang Qin, Harukazu Suzuki, Masao Honda, Hikari Okada, Shuichi Kaneko, Ikuyo Inoue, Etsuko Ebisui, Kosuke Hashimoto, Piero Carninci, Keita Kanki, Hideki Tatsukawa, Naoto Ishibashi, Takahiro Masaki, Tomokazu Matsuura, Hiroyuki Kagechika, Kan Toriguchi, Etsuro Hatano, Yohei Shirakami, Goshi Shiota, Masahito Shimizu, Hisataka Moriwaki, Soichi Kojima,
Significance Hepatocellular carcinoma (HCC) is a highly lethal cancer, partly because of its high rate of recurrence, which is caused by the presence of liver cancer stem cells (CSCs). Here, using a selective chemopreventive agent, acyclic retinoid (ACR), as a bioprobe, we identified MYCN , which is mostly recognized as an oncogene in neuroblastoma, as a therapeutic target of ACR for HCC through a selective deletion of MYCN + liver CSCs. We also demonstrated that the expression of MYCN in HCC served as ...
Tópico(s): Protein Degradation and Inhibitors
2018 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Akitoshi Inoue, Etsuko Sawatari, Naoki Hisamoto, Tomohiro Kitazono, Takayuki Teramoto, Manabi Fujiwara, Kunihiro Matsumoto, Takeshi Ishihara,
The control of memory retention is important for proper responses to constantly changing environments, but the regulatory mechanisms underlying forgetting have not been fully elucidated. Our genetic analyses in C. elegans revealed that mutants of the TIR-1/JNK-1 pathway exhibited prolonged retention of olfactory adaptation and salt chemotaxis learning. In olfactory adaptation, conditioning induces attenuation of odor-evoked Ca2+ responses in olfactory neurons, and this attenuation is prolonged in ...
Tópico(s): Circadian rhythm and melatonin
2013 - Cell Press | Cell Reports
Asuka Terashima, Hiroshi Watarai, Sayo Inoue, Etsuko Sekine, Ryusuke Nakagawa, Koji Hase, Chiaki Iwamura, Hiroshi Nakajima, Toshinori Nakayama, Masaru Taniguchi,
Airway hypersensitive reaction (AHR) is an animal model for asthma, which is caused or enhanced by environmental factors such as allergen exposure. However, the precise mechanisms that drive AHR remain unclear. We identified a novel subset of natural killer T (NKT) cells that expresses the interleukin 17 receptor B (IL-17RB) for IL-25 (also known as IL-17E) and is essential for the induction of AHR. IL-17RB is preferentially expressed on a fraction of CD4+ NKT cells but not on other splenic leukocyte ...
Tópico(s): Asthma and respiratory diseases
2008 - Rockefeller University Press | The Journal of Experimental Medicine
Hiroaki Hayashi, Etsuko Miwa, Ken‐ichiro Inoue,
Two known saponins, licorice-saponin H2 and macedonoside A, were isolated from the stolons of Glycyrrhiza lepidota (American licorice) as major saponins. Since licorice-saponin H2 and macedonoside A are minor saponins isolated from the three glycyrrhizin-producing species (i.e. G. glabra, G. uralensis, G. inflata) and the three macedonoside C-producing species (i.e. G. macedonica, G. echinata, G. pallidiflora), respectively, the present study suggests that G. lepidota is an intermediate of both glycyrrhizin- ...
Tópico(s): Natural product bioactivities and synthesis
2005 - Pharmaceutical Society of Japan | Biological and Pharmaceutical Bulletin
Osamu Inoue, Etsuko Kanno, Kiyoto Kasai, Hirohiko Ukai, Shiki Okamoto, Masayuki Ikeda,
The present study was initiated to examine whether urinary benzylmercapturic acid (or N-acetyl-S-benzyl cysteine, BMA), a mercapturate metabolite of toluene, increases in relation to the intensity of toluene exposure, and whether this metabolite is a better marker of occupational exposure to toluene than two traditional markers, hippuric acid and o-cresol. Accordingly, end-of-shift urine samples were collected from 122 printers and 30 office clerks (all men) in the second half of a working week. Solvent ( ...
Tópico(s): Air Quality and Health Impacts
2003 - Elsevier BV | Toxicology Letters
Toshihisa Ohtsuka, Etsuko Takao‐Rikitsu, Eiji Inoue, Marie Inoue, Masakazu Takeuchi, Kaho Matsubara, Maki Deguchi‐Tawarada, Keiko Satoh, Koji Morimoto, Hiroyuki Nakanishi, Yoshimi Takai,
The cytomatrix at the active zone (CAZ) has been implicated in defining the site of Ca2+-dependent exocytosis of neurotransmitter. We have identified here a novel CAZ protein of ∼120 kD from rat brain and named it CAST (CAZ-associated structural protein). CAST had no transmembrane segment, but had four coiled-coil domains and a putative COOH-terminal consensus motif for binding to PDZ domains. CAST was localized at the CAZ of conventional synapses of mouse brain. CAST bound directly RIM1 and indirectly ...
Tópico(s): Neuroscience and Neuropharmacology Research
2002 - Rockefeller University Press | The Journal of Cell Biology
Osamu Inoue, Etsuko Kanno, Toshiharu Yusa, MASAEI KAKIZAKI, Hirohiko Ukai, Satoru Okamoto, Kae Higashikawa, Masayuki Ikeda,
Tópico(s): Occupational exposure and asthma
2002 - Springer Science+Business Media | International Archives of Occupational and Environmental Health
Osamu Inoue, Etsuko Kanno, Toshiharu Yusa, MASAEI KAKIZAKI, Takao Watanabe, Kae Higashikawa, Masayuki Ikeda,
The objective of this study was to establish a hand-saving method to measure phenylmercapturic acid (PMA) and to examine urinary PMA as a marker of occupational exposure to benzene at levels less than 1 ppm. A simple HPLC method was developed to analyse PMA by monitoring absorption at 195 nm of the ef? uent from an ODS-3 column with acetonitrile-methanol-perchloric acid-water as a mobile phase. The detection limit of the method was 0.2 μg l(-1) with sufficient reproducibility. The method was applied ...
Tópico(s): Carcinogens and Genotoxicity Assessment
2001 - Taylor & Francis | Biomarkers
Yoshio Uetsuka, Saichi HOSODA, Hiroshi Kasanuki, M Aosaki, Kagari Murasaki, Katsuyoshi Ooki, M. Inoue, Etsuko Akiyama, Masukazu Kitada,
Tópico(s): Antiplatelet Therapy and Cardiovascular Diseases
2000 - Springer Science+Business Media | Heart and Vessels
Osamu Inoue, Etsuko Kanno, MASAEI KAKIZAKI, Takao Watanabe, Kae Higashikawa, Masayuki Ikeda,
A hand-saving HPLC method to measure urinary phenylmercapturic acid (PMA) was developed which allows about 35 PMA determinations per day. The method involves conversion of pre-PMA to PMA by the addition of sulfuric acid to a urine sample, extraction into an ether-methanol mixture followed by condensation under a nitrogen stream. The condensate was introduced to a ODS-3 column in a HPLC system, and PMA in the column was eluted into a mobile phase of acetonitrile: methanol: perchloric acid: water. ...
Tópico(s): Air Quality and Health Impacts
2000 - National Institute of Occupational Safety and Health | Industrial Health