Prof. J. Taft, Dr. J. A. Robinson, E. G. Betty, W. C. Brittan, Norman W. Kingsley, E. R. McMullen, John M. Keating, T. R. Buckham, E. G. Betty, G. R. Thomas, G. J. Friedrichs,
... Hydrophobia Have Recently Occurred among Camels in Algeria, Eugenol, Laft-Handedness, The Influence of Climate and Soil ...
1887 - Gale Group | NCCO-STM 1of2
... were determined. Zinc phosphate cement, zinc oxide and eugenol (quick-set) cement, zinc oxide and eugenol (fortified) cement, and Tubliseal all set too quickly ... were found to be satisfactory: zinc oxide and eugenol cement, zinc oxide and eugenol (quick-set) cement, zinc oxide and eugenol (fortified) cement, Grossman's (new) sealer, Rickert's ... time. This also happened with zinc oxide and eugenol (fortified) cement, Diaket, and AH-26. Of those that maintained their strength, zinc oxide and eugenol cement was the best. 4. The tissue reactions ...
Tópico(s): Shoulder and Clavicle Injuries
1968 - Elsevier BV | Oral Surgery Oral Medicine Oral Pathology
P. S. Conner, Prof. W. W. Seely, B. S. Woodworth, N. E. Charlton, G. R. Cutter,
... Suits, Horsford's Acid Phosphate, An Odd Suit, Eugenol, or in Better English, Engenin, the New Antiseptic, ...
1881 - Gale Group | NCCO-STM 1of2
Jerry G. Webb, Norman E. Bussell,
Eugenol "purified" by HPLC20 was compared to commercial USP eugenol to determine if any difference exists between the inflammatory response caused by each. Mixtures of each eugenol with zinc oxide were also compared. Each material ... of necrosis and inflammation was compared. The purified eugenol caused less necrosis and inflammation at all times than did the commercial eugenol. The purified ZOE mixture produced less necrosis and ... mixtures of ZOE and the two samples of eugenol produced roughly parallel amounts of inflammation, suggesting that ...
Tópico(s): Historical Medical Research and Treatments
1981 - SAGE Publishing | Journal of Dental Research
... Reform, 1903. On the Production of Vanillin from Eugenol. Article.
0000 - Gale Group | NCCO EuropeAfrica
Donald R. Morse, Bayardo Martell, Calvin G. Pike, John E Fantasia, John V. Esposito, Merrick L. Furst,
Zinc oxide-eugenol (0.05 ml), chloropercha, eucapercha, and xylolpercha were injected into circumscribed areas (10 mm in diameter) in the ... inflammation ratings showed that xylolpercha and zinc oxide-eugenol caused significantly more inflammation than either chloropercha or ... was significantly better than xylolpercha and zinc oxide-eugenol but eucapercha was significantly better than the other three test sealers. Zinc oxide-eugenol (0.05 ml), chloropercha, eucapercha, and xylolpercha were ... inflammation ratings showed that xylolpercha and zinc oxide-eugenol caused significantly more inflammation than either chloropercha or ...
Tópico(s): Poisoning and overdose treatments
1984 - Elsevier BV | Journal of Endodontics
Atsufumi Manabe, Sadao NAKAYAMA, Koji Sakamoto,
The effect of essential oils, eugenol, thymol and menthol, on erythrocytes, hepatocytes, dipalmitoyl phosphatidylcholine (DPPC)-liposomes and surface tension were studied at various concentrations. Maximal inhibition of eugenol, thymol and menthol on the hypotonic hemolysis in ... 2 mM, 1 mM and 1 mM, respectively. Eugenol at 4 mM and thymol at 2 mM ... thymol caused an increase in GOT leakage, but eugenol at 4 mM and menthol at 0.1 ... leakage of GPT from hepatocytes was inhibited by eugenol at 0.1 mM and 0.4 to ...
Tópico(s): Erythrocyte Function and Pathophysiology
1987 - Japanese Pharmacological Society | The Japanese Journal of Pharmacology
David R. Thompson, Thomas E. Eling,
... of inhibition of prostaglandin H synthase (PHS) by eugenol was investigated using purified apoenzyme reconstituted with either ... protoporphyrin IX (Mn-PHS) or hematin (Fe-PHS). Eugenol stimulated Fe-PHS activity at low concentrations and ... concentrations, an activity typical of many phenolic compounds. Eugenol was also an excellent reducing cosubstrate for the ... quinone methide in the process. Higher concentrations of eugenol were required to inhibit Fe-PHS than Mn- ... cyclooxygenase activity but not peroxidase activity). Inhibition by eugenol was highly dependent on arachidonic acid concentration. In ...
Tópico(s): Metal-Catalyzed Oxygenation Mechanisms
1989 - American Society for Pharmacology and Experimental Therapeutics | Molecular Pharmacology
... factors contributing to the blandness of zinc oxide-eugenol preparations in vivo Sylvia D. MERYON, Corresponding Author ... 1976) Pulpal reaction to a temporary zinc oxide/eugenol cement. Journal of Prosthetic Dentistry, 35, 185–191. Fujlsawa, S. & Masuhara, E. (1981) Binding of eugenol and O–ethoxybenzoic acid to bovine serum albumin. ... 102–107. Hume, W.R. (1984a) Effect of eugenol on respiration and division in human pulp, mouse ... the release and the diffusion through dentine of eugenol from zinc oxide–eugenol mixtures. Journal of Dental ...
Tópico(s): dental development and anomalies
1988 - Wiley | International Endodontic Journal
Darina Slameňová, Eva Horváthová, Ladislava Wsólová, Monika Šrámková, Jana Navarová,
... cytotoxic, genotoxic and possible DNA-protective effects of eugenol and borneol. Anti-oxidative activities of aqueous and ... concentrations soluble in water or ethanol (<1000mM), while eugenol did manifest anti-oxidative activity, and at much lower concentrations (5-100 microM). The cytotoxicity of eugenol and borneol as well as their DNA-damaging ... in the three cell lines the cytotoxicity of eugenol was significantly higher than that of borneol. Single- ... concentrations studied, but showed that all concentrations of eugenol (<600 microM) significantly increased the level of DNA ...
Tópico(s): Plant chemical constituents analysis
2009 - Elsevier BV | Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Santanu Kar Mahapatra, Subhankari Prasad Chakraborty, Subrata Majumdar, Braja Gopal Bag, Somenath Roy,
... is aimed at evaluating the protective effect of eugenol against in vitro nicotine-induced toxicity in murine peritoneal macrophages, compared with N-acetylcysteine. Eugenol was isolated from Ocimum gratissimum and characterized by ... protective support, we used five different concentrations of eugenol (1, 5, 10, 15, and 20 μg/ml) ... protective effect was observed with all doses of eugenol and N-acetylcysteine, as evidenced by decreased level ... at the concentration of 15.0 μg/ml eugenol (0.09 nM) and 1.0 μg/ml ...
Tópico(s): Olfactory and Sensory Function Studies
2009 - Elsevier BV | European Journal of Pharmacology
Gurpreet Kaur, Mohammad Athar, Mohammad Sarwar Alam,
... was designed to investigate the protective efficacy of eugenol against skin cancer and probe into the mechanistic ... promotion. However, in mice pretreated with 30 µL eugenol, no tumors were detected until 8 wk (following ... promotion. PCNA and TUNEL immunohistochemistry of tumors revealed eugenol to ameliorate cell proliferation and elevate apoptosis respectively. The effect of eugenol was assessed on specific stages of carcinogenesis. Initiation ... of damage to the DNA. However, pretreatment with eugenol led to overexpression of these genes, which probably ...
Tópico(s): melanin and skin pigmentation
2009 - Wiley | Molecular Carcinogenesis
Produção Nacional
Revisado por pares
Apparecido N. Daniel, Simone Sartoretto, Gustavo Schmidt, Silvana Martins Caparroz‐Assef, Ciomar Aparecida Bersani‐Amado, Roberto Kenji Nakamura Cuman,
... processing, pharmacy; perfumery, cosmetics and the clove oil (eugenol) have been used in folk medicine for manifold ... evaluated the anti-inflammatory and antinociceptive activity of eugenol used for dentistry purposes following oral administration in ... models in vivo. The anti-inflammatory activity of eugenol was evaluated by inflammatory exudates volume and leukocytes ... induced writhing and hot-plate tests in mice. Eugenol (200 and 400 mg/kg) reduced the volume ... leukocyte counts. At dose of 200 mg/kg, eugenol significantly inhibited carrageenan-induced edema, 2-4 h ...
Tópico(s): Natural product bioactivities and synthesis
2009 - Springer Science+Business Media | Revista Brasileira de Farmacognosia
Saša M. Trailović, Robertson P.A., Jelena Nedeljković-Trailović,
Eugenol, an essential oil of clove oil possesses several different pharmacological properties, including antimicrobial, antifungal, insecticidal and antihelmintic. With regard to the digestive tract, eugenol has shown spasmolitic and relaxant effects. To elucidate some of the mechanisms involved, the effects of eugenol on contractions of isolated rat ileum induced by electrical field stimulation (EFS) were investigated. Eugenol (100 µM) significantly and reversibly reduced EFS induced ... 18 g, while contractions in the presence of eugenol decreased to 0.40±0.02 g (n= ...
Tópico(s): Ion Channels and Receptors
2009 - De Gruyter Open | Acta veterinaria
Chul‐Kyu Park, Kihwan Kim, Sung Jun Jung, Min Ji Kim, Dong Kuk Ahn, Seong‐Doo Hong, Joong Soo Kim, Seog Bae Oh,
Eugenol is widely used in dentistry as a local analgesic agent, because of its ability to allay tooth pain. Interestingly, eugenol shares several pharmacological actions with local anesthetics which ... the present study, we investigated the effects of eugenol on pain behaviors in orofacial area, and as ... elucidate its mechanism we characterized inhibitory effects of eugenol on VGSCs in trigeminal ganglion (TG) neurons. TG ... PCR following whole-cell recordings. Subcutaneous injection of eugenol reduced the thermal nociception and capsaicin-induced thermal ...
Tópico(s): Olfactory and Sensory Function Studies
2009 - Lippincott Williams & Wilkins | Pain
Tomoharu Maseki, Kazuhiko Nakata, Toshiaki Kohsaka, Fuminori Kobayashi, Shinei Hirano, Hiroshi Nakamura,
... was to examine a possible correlation between the eugenol released from a zinc oxide-eugenol sealer (Canals) and the degree of cytotoxicity. The cytotoxicity and eugenol release from root canal filling material containing eugenol was examined for test solutions at several experimental periods. No positive correlation was found between eugenol release and cytotoxicity of the root canal filling ... was to examine a possible correlation between the eugenol released from a zinc oxide-eugenol sealer (Canals) ...
Tópico(s): Poisoning and overdose treatments
1991 - Elsevier BV | Journal of Endodontics
David C. Thompson, Despina Constantin-Teodosiu, Peter Moldéus,
The metabolism and toxic effects of eugenol (4-allyl-2-methoxyphenol) were studies in isolated rat hepatocytes. Incubation of hepatocytes with eugenol resulted in the formation of conjugates with sulfate, ... binding to cellular protein was observed using [3H]eugenol. Loss of intracellular glutathione and cell death were ... observed in these incubations. Concentrations of 1 mM eugenol caused a loss of over 90% of intracellular ... of cell death (2 h). The effects of eugenol were concentration dependent. The addition of 1 mM ...
Tópico(s): Genomics, phytochemicals, and oxidative stress
1991 - Elsevier BV | Chemico-Biological Interactions
Kenneth Markowitz, Michael R Moynihan, Mintsai Liu, Syngcuk Kim,
Eugenol-containing dental materials are frequently used in clinical dentistry. When zinc oxide-eugenol (ZOE) is applied to a dentinal cavity, small quantities of eugenol diffuse through the dentin to the pulp. Low concentrations of eugenol exert anti-inflammatory and local anesthetic effects on ... facilitate pulpal healing; on the other hand, high eugenol concentrations are cytotoxic. Direct application of eugenol to pulp tissue may result in extensive tissue ... periapical tissue healing is considered in view of eugenol's anti-inflammatory and toxic properties.
Tópico(s): Dental Anxiety and Anesthesia Techniques
1992 - Elsevier BV | Oral Surgery Oral Medicine Oral Pathology
Enika Nagababu, N. Lakshmaiah,
The anti-peroxidative activity of eugenol on Fe(2+)-ascorbate- and Fe(2+)-H2O2-induced lipid peroxidation was studied using rat liver mitochondria. Eugenol inhibited thiobarbituric acid reactive substance (TBARS) formation induced ... studies on TBARS formation indicated the ability of eugenol to inhibit initiation and propagation reactions. There was no measurable chemical modification of eugenol during the course of mitochondrial peroxidation by both ... mannitol, benzoate, formate and dimethyl sulfoxide apart from eugenol. The OH scavenging ability of eugenol was evident ...
Tópico(s): Free Radicals and Antioxidants
1992 - Elsevier BV | Biochemical Pharmacology
Seiichiro Fujisawa, Toshiko Atsumi, Yoshinori Kadoma, Hiroshi Sakagami,
... possible link between radicals and the cytotoxicity of eugenol-related compounds, 2-allyl-4-X-phenols (2- ... 2,4-dimethoxyphenol (9)), and dimeric compounds from eugenol (4-allyl-2-methoxyphenol), BHA (2-t-butyl- ... butylhydroxytoluine, BHT; butylhydroxyanisole, BHA; alpha-tocopherol (alpha-Toc); eugenol, phenol) were studied. Erectron spin resonance (ESR) spectroscopy suggested that compounds of 3, 6, 9, eugenol and BHA, but not compounds of 10, 11, ... alkaline solutions (pH>9.5) and compounds, 3, eugenol and 9 most efficiently scavenged reactive oxygen species ( ...
Tópico(s): Essential Oils and Antimicrobial Activity
2002 - Elsevier BV | Toxicology
S Fujisawa, T Atsumi, Keitaro Satoh, Hiroshi Sakagami,
... cements is composed of 2-ethoxybenzoic acid and eugenol (4-allyl-2-methoxyphenol). Recently, eugenol was reported to produce radicals at a higher ... consequently directly damages cells. We examined here whether eugenol radicals are generated from the mixture of eugenol/calcium hydroxide, and also whether 2-ethoxybenzoic acid ... spectroscopy. Radicals were generated from the mixture of eugenol/calcium hydroxide in 50% dimethylsulfoxide solution. The radical intensity of eugenol in 50% dimethylsulfoxide with 0.1 M sodium ...
Tópico(s): Synthesis of Organic Compounds
2003 - SAGE Publishing | Journal of Dental Research
Yukio Murakami, Masao Shoji, Shigemasa Hanazawa, Shoji Tanaka, Seiichiro Fujisawa,
Eugenol exhibits antioxidant and anti-inflammatory activities, but at higher concentrations acts as an oxidant and potent allergen. It was earlier shown that bis-eugenol synthesized by the oxidation of eugenol was less cytotoxic and more highly antioxidative than eugenol. But its anti-inflammatory mechanism remains yet unclear. ... the expression of inflammatory cytokines, we examined whether eugenol and bis-eugenol are inhibitors of NF-kappa B activation. We observed that bis-eugenol, but not eugenol, clearly inhibited the degradation of ...
Tópico(s): Genomics, phytochemicals, and oxidative stress
2003 - Elsevier BV | Biochemical Pharmacology
Funda Bayındır, Musa Şamil Akyıl, Yusuf Ziya Bayındır,
... crowns to pretreatment of composite resin cores with eugenol and non-eugenol containing temporary cements, 2) to determine the microhardness ... walls of the composite cores were covered with eugenol-containing temporary cement, Group 3, The external walls of the composite cores were covered with non-eugenol containing temporary cement.Analysis of variance results showed ... difference between all three groups. Temporary cement with eugenol was significantly reduced the bond strength of full crown casting with resin cement compared with non-eugenol.The resin specimens treated with the eugenol-containing ...
Tópico(s): Bone Tissue Engineering Materials
2003 - Japanese Society for Dental Materials and Devices | Dental Materials Journal
Enika Nagababu, N. Lakshmaiah,
AbstractPreviously we reported that eugenol (4-allyl-2-methoxyphenol) inhibits non-enzymatic peroxidation in liver mitochondria (E. Nagababu and N. Lakshmaiah, 1992, Biochemical Pharmacology. 43, ... the present study, we examined the effect of eugenol on microsomal mixed function oxidase mediated peroxidation using ... cumene hydroperoxide (CumOOH) systems. In the presence of eugenol the formation of thiobarbituric acid reactive substances (TBARS) ... efficacy was in the order: butylated hydroxytoluene (BHT) > eugenol > α-tocopherol, while in CCl4-NADPH system the ...
Tópico(s): Essential Oils and Antimicrobial Activity
1994 - Taylor & Francis | Free Radical Research
Jiiang‐Huei Jeng, L.J. Hahn, EJ Lu, YJ Wang, Mark Yen‐Ping Kuo,
Pathobiological effects of eugenol (4-allyl-2-methoxyphenol), a major constituent of betel quid (BQ), were studied on oral mucosal fibroblasts. At a concentration higher than 3 mmol/L, eugenol was cytotoxic to oral mucosal fibroblasts in a ... of 3 mmol/L and 4 mmol/L, eugenol depleted about 45% and 77% of GSH after one-hour incubation. In addition, eugenol decreased cellular ATP level in a concentration- and time-dependent manner. Eugenol also inhibited lipid peroxidation. Inhibition of lipid peroxidation ...
Tópico(s): Garlic and Onion Studies
1994 - SAGE Publishing | Journal of Dental Research
Achour Amiri, Robert Dugas, Anne L. Pichot, G. Bompeix,
The activity of eugenol oil was evaluated in vitro and in vivo against four apple pathogens namely Phlyctema vagabunda, Penicillium expansum, Botrytis cinerea ... Monilinia fructigena. The minimum inhibitory concentration (MIC) of eugenol incorporated in malt extract agar medium was found ... treated with 150 µl l− 1 of volatile eugenol whether at 4 or 20 °C. Conidia of ... and B. cinerea suspended for 2 min in eugenol solution at 2 mg ml− 1 heated to ... 19, 37, 38 and 39%, respectively. Three different eugenol formulations (Tween 80, ethoxylate and lecithin) were tested ...
Tópico(s): Mycotoxins in Agriculture and Food
2008 - Elsevier BV | International Journal of Food Microbiology
Jeong Seon Cho, Tae Hoon Kim, Jae‐Min Lim, Jin-Ho Song,
Eugenol is an aromatic molecule found in several plants and widely used in dentistry for analgesic and ... elucidate an involvement of Na+ channels in the eugenol-induced analgesia we investigated the effects of eugenol on tetrodotoxin-sensitive (TTX-S) and tetrodotoxin-resistant ( ... in acutely dissociated rat dorsal root ganglion neurons. Eugenol inhibited TTX-S and TTX-R Na+ currents ... values were 308 μM and 543 μM, respectively. Eugenol did not influence the activation voltage of either type of Na+ current. However, eugenol moved the steady-state inactivation curves of both ...
Tópico(s): Plant-based Medicinal Research
2008 - Elsevier BV | Brain Research
Mi‐Jung Choi, Apinan Soottitantawat, Onanong Nuchuchua, Sang‐Gi Min, Uracha Ruktanonchai,
... this research was to study the encapsulation of eugenol as a volatile active substance by inclusion with ... microscopy (AFM). Overall, the mean sizes of encapsulated eugenol were the same at 320 nm. However, the ... inclusion complex was poly-disperse as compared with eugenol encapsulated with polycaprolactone (PCL). TGA analysis revealed the encapsulation efficiency of PCL, β-CD eugenol and 2-HP-β-CD eugenol inclusion complexes were 100%, 90.9% and 89. ... more effective than 2-HP-β-CD for eugenol encapsulation. It is supposed that the side chain ...
Tópico(s): Surfactants and Colloidal Systems
2008 - Elsevier BV | Food Research International
Katja Schulz, Katja Schlenz, Steffen Malt, Robert Metasch, Wolfgang Römhild, Jan Dreßler, Dirk W. Lachenmeier,
... method has been developed for the determination of eugenol in serum samples after enzymatic cleavage. Eugenol is a characteristic marker for the consumption of ... aged spirits. This method enables the detection of eugenol with a limit of detection (LOD) of 3. ... coefficient R2 = 0.992). Our findings confirm that eugenol undergoes a rapid phase II metabolism as it occurs completely conjugated as eugenol glucuronide in serum. Free eugenol was not detectable in any of our samples, ... these blood samples, concentration/time profiles for serum eugenol glucuronide were determined. A rapid resorption leads to ...
Tópico(s): Alcohol Consumption and Health Effects
2008 - Elsevier BV | Journal of Chromatography A
Bora Bağış, Pergin Atilla, Nur Çakar, U Hasanreisoğlu,
... were cemented to the prepared teeth with either eugenol-containing or eugenol-free temporary cement and extracted 24 or 48 ... in samples removed 48 h after treatment with eugenol-containing cement compared with intact teeth. This reduction ... significant only for ICAM-1 for 48-h eugenol-free samples. Moreover, the eugenol-free cement group indicated considerably higher E-selectin, ... 1, and VCAM-1 expression compared with the eugenol-containing group (P < .005) 48 h after the ... were cemented to the prepared teeth with either eugenol-containing or eugenol-free temporary cement and extracted ...
Tópico(s): Inflammatory mediators and NSAID effects
2008 - Elsevier BV | Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology