Clément Larue, Eva Austruy, Gaëlle Basset, Rémy J. Petit,
Wind, insects, or both? The pollination mode of chestnuts, an important genus of nut-producing forest trees of the Fagaceae family, is still unclear. We revisit this old question using an integrated approach, focusing on cultivated Castanea sativa trees and hybrids in South-western France. We first conducted a large-scale insect isolation experiment. We then monitored 16 trees, focusing on flowering phenology, flower abundance and insect visits. Half of these trees are male-sterile, helping explore ...
Tópico(s): Horticultural and Viticultural Research
2021 - Société botanique de France | Botany Letters
Jan LaRue, Eva Badura-Skoda, Paul Badura-Skoda, Leo Black,
Tópico(s): Diverse Musicological Studies
1963 - Music Library Association | Notes
Sahar Hamed, Hélène LaRue, Hélène Hovington, Johanne Girard, Lucie Jeannotte, Éva Latulippe, Yves Fradet,
Abstract The PATCHED (PTC) gene is recognized as a tumor suppressor in basal cell carcinoma. Mapping of a minimal region of deletion at 9q22.3 and observation of a decreased PTC expression in superficial papillary bladder tumors led us to hypothesize that it could also be involved in this cancer. To further investigate this hypothesis, we submitted Ptc+/− heterozygous mutant mice and their wild-type littermates to chemical carcinogenesis by adding N-butyl-N-(4-hydroxybutyl) nitrosamine to their drinking ...
Tópico(s): Cancer and Skin Lesions
2004 - American Association for Cancer Research | Cancer Research
Eva Roubeau Dumont, Camille Larue, Sophie Lorber, Hervé Gryta, Élise Billoir, Elisabeth M. Gross, Arnaud Elger,
To limit anthropogenic impact on ecosystems, regulations have been implemented along with global awareness that human activities are harmful to the environment. Ecological risk assessment (ERA) is the main procedure which allows to assess potential impacts of stressors on the environment as a result of human activities. ERA is typically implemented through different steps of laboratory testing. The approaches taken for ERA evolve along with scientific knowledge, to improve predictions on ecological ...
Tópico(s): Allelopathy and phytotoxic interactions
2019 - Elsevier BV | Aquatic Toxicology
Eva Hoster, Marie‐Hélène Delfau‐Larue, Elizabeth Macintyre, Linmiao Jiang, Stephan Stilgenbauer, Ursula Vehling‐Kaiser, Gilles Salles, Catherine Thiéblemont, Hervé Tilly, Stefan Wirths, Pierre Feugier, Kai Hübel, Christian Schmidt, Vincent Ribrag, Hanneke C. Kluin‐Nelemans, Martin Dreyling, Christiane Pott,
PURPOSE The outcome of older patients with mantle cell lymphoma (MCL) has improved by the introduction of immunochemotherapy, followed by rituximab (R)-maintenance. Assessment of minimal residual disease (MRD) represents a promising tool for individualized treatment decisions and was a prospectively planned part of the European MCL Elderly trial. We investigated how MRD status influenced the efficacy of R-maintenance and how MRD can enable tailored consolidation strategies. PATIENTS AND METHODS Previously ...
Tópico(s): Sarcoma Diagnosis and Treatment
2023 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Christiane Pott, Eva Hoster, Marie‐Hélène Delfau‐Larue, Kheïra Beldjord, Sebastian Böttcher, Vahid Asnafi, Anne Plonquet, Reiner Siebert, Evelyne Callet‐Bauchu, Niels Smedegaard Andersen, Jacques J. M. van Dongen, Wolfram Klapper, Françoise Berger, Vincent Ribrag, Achiel L. van Hoof, Marek Trněný, Jan Walewski, Peter Dreger, Michael Unterhalt, Wolfgang Hiddemann, Michael Kneba, Hanneke C. Kluin‐Nelemans, Olivier Hermine, Elizabeth Macintyre, Martin Dreyling,
Abstract The prognostic impact of minimal residual disease (MRD) was analyzed in 259 patients with mantle cell lymphoma (MCL) treated within 2 randomized trials of the European MCL Network (MCL Younger and MCL Elderly trial). After rituximab-based induction treatment, 106 of 190 evaluable patients (56%) achieved a molecular remission (MR) based on blood and/or bone marrow (BM) analysis. MR resulted in a significantly improved response duration (RD; 87% vs 61% patients in remission at 2 years, P = .004) and ...
Tópico(s): Chronic Lymphocytic Leukemia Research
2009 - Elsevier BV | Blood
Kristin Hamre, Elisabeth Holen, Mari Moren,
... 127, 3031– 3044. Pla, P., Alberti, C., Solov‘eva, O., Pasdar, M., Kunisada, T. & Larue, L. (2005) Ednrb2 orients cell migration towards the ...
Tópico(s): Aquaculture disease management and microbiota
2007 - Wiley | Aquaculture Nutrition
J. Rigaud, Rabi Tiguert, Marc Decobert, Hélène Hovington, Éva Latulippe, Jacques Laverdière, Hélène LaRue, Louis Lacombe, Yves Fradet,
To assess whether the expression of p21, p27, and p53 could predict biochemical failure in prostate cancer patients treated with neoadjuvant androgen deprivation prior to salvage radiotherapy for a rising post-radical prostatectomy (RP) prostate-specific antigen (PSA).The expression of p21, p27, and p53 was determined by immunohistochemistry in a cohort of 74 formalin-fixed paraffin-embedded prostate cancer samples obtained from RP. Expression of these markers was then correlated with clinicopathological ...
Tópico(s): Prostate Cancer Diagnosis and Treatment
2003 - Wiley | The Prostate
Anis Aziz, Annie Lessard, Katherine Moore, Hélène Hovington, Éva Latulippe, Hélène LaRue, Yves Fradet, Louis Lacombe,
Study Type - Prognosis (case series).4 OBJECTIVE: To determine whether the expression of cyclo-oxygenase (COX)-2 has an influence on survival and on the response to chemotherapy in invasive bladder cancer.A population of 266 patients from a tertiary university centre with carcinoma invading bladder muscle without evidence of metastasis at time of cystectomy was analyzed retrospectively. COX-2 expression was evaluated immunohistochemically with a monoclonal anti-COX-2 antibody. All pertinent clinical ...
Tópico(s): Urinary and Genital Oncology Studies
2010 - Wiley | BJU International
Christiane Pott, Elizabeth Macintyre, Marie‐Hélène Delfau‐Larue, Vincent Ribrag, Michael Unterhalt, Michael Kneba, Wolfgang Hiddemann, Martin Dreyling, Olivier Hermine, Eva Hoster,
Tópico(s): Chronic Lymphocytic Leukemia Research
2014 - Elsevier BV | Blood
Eva Roubeau Dumont, Camille Larue, Benoît Pujol, Thierry Lamaze, Arnaud Elger,
Tópico(s): Pharmaceutical and Antibiotic Environmental Impacts
2019 - Springer Science+Business Media | Environmental Science and Pollution Research
Eva Roubeau Dumont, Camille Larue, Hiram Castillo Michel, Hervé Gryta, Clarisse Liné, David Baqué, Elisabeth M. Gross, Arnaud Elger,
Tópico(s): Aquatic Ecosystems and Phytoplankton Dynamics
2019 - Elsevier BV | Chemosphere
Sietse Aukema, Eva Hoster, Andreas Rosenwald, D. Canoni, Marie‐Hélène Delfau‐Larue, Grzegorz Rymkiewicz, Christoph Thorns, Sylvia Hartmann, Hanneke C. Kluin‐Nelemans, Olivier Hermine, Martin Dreyling, Wolfram Klapper,
Tópico(s): RNA Research and Splicing
2017 - Elsevier BV | Blood
Morgane Cheminant, Coralie Derrieux, Aurore Touzart, Stephanie L. Schmit, A Grenier, A. Trinquand, Marie‐Hélène Delfau‐Larue, Ludovic Lhermitte, Catherine Thiéblemont, Vincent Ribrag, S. Chèze, Laurence Sanhès, F. Jardin, F. Lefrère, Richard Delarue, Eva Hoster, M. Dreyling, Vahid Asnafi, Olivier Hermine, Elizabeth Macintyre,
Quantification of minimal residual disease may guide therapeutic strategies in mantle cell lymphoma. While multiparameter flow cytometry is used for diagnosis, the gold standard method for minimal residual disease analysis is real-time quantitative polymerase chain reaction (RQ-PCR). In this European Mantle Cell Lymphoma network (EU-MCL) pilot study, we compared flow cytometry with RQ-PCR for minimal residual disease detection. Of 113 patients with at least one minimal residual disease sample, RQ- ...
Tópico(s): Cutaneous lymphoproliferative disorders research
2015 - Ferrata Storti Foundation | Haematologica
Eva Roubeau Dumont, Arnaud Elger, Céline Azéma, Hiram Castillo Michel, Suzy Surblé, Camille Larue,
Copper oxide nanoparticles (CuO-NPs) have been increasingly released in aquatic ecosystems over the past decades as they are used in many applications. Cu toxicity to different organisms has already been highlighted in the literature, however toxicity mechanisms of the nanoparticulate form remain unclear. Here, we investigated the effect, transfer and localization of CuO-NPs compared to Cu salt on the aquatic plant Myriophyllum spicatum, an ecotoxicological model species with a pivotal role in freshwater ...
Tópico(s): Electrochemical Analysis and Applications
2021 - Elsevier BV | The Science of The Total Environment
Martin Dreyling, Hanneke C. Kluin‐Nelemans, Sı́lvia Beà, Wolfram Klapper, Niclas Vogt, Marie‐Hélène Delfau‐Larue, Grit Hutter, Chan Y. Cheah, Annalisa Chiappella, Sergio Cortelazzo, Christiane Pott, Georg Heß, Carlo Visco, Umberto Vitolo, Pavel Klener, Igor Aurer, Michael Unterhalt, Vincent Ribrag, Eva Hoster, Olivier Hermine,
Mantle cell lymphoma (MCL) is a distinct subtype of malignant lymphoma characterized by the chromosomal translocation t(11;14)(q13;q32), resulting in constitutional overexpression of cyclin D1 and cell cycle dysregulation in virtually all cases. Clinically, MCL displays an aggressive course, with a continuous relapse pattern and a median survival of only 3-7 years. However, a subset of up to 15% long-term survivors has recently been identified with a rather indolent clinical course. In general, conventional ...
Tópico(s): Chronic Lymphocytic Leukemia Research
2012 - Taylor & Francis | Leukemia & lymphoma/Leukemia and lymphoma
Marie‐Hélène Delfau‐Larue, Wolfram Klapper, Françoise Berger, Fabrice Jardin, Josette Brière, Gilles Salles, Olivier Casasnovas, Pierre Feugier, Corinne Haïoun, Vincent Ribrag, Catherine Thiéblemont, Michael Unterhalt, Martin Dreyling, Elizabeth Macintyre, Christiane Pott, Olivier Hermine, Eva Hoster,
We revisited the prognostic value of frequently detected somatic gene copy number alterations (CNAs) in mantle cell lymphoma (MCL) patients treated first line with immunochemotherapy and autologous stem cell transplantation (ASCT), with or without high-dose cytarabine, in the randomized European MCL Younger trial. DNA extracted from tumor material of 135 patients (median age, 56 years) was analyzed by multiplex ligation-dependent probe amplification and/or quantitative multiplex polymerase chain reaction ...
Tópico(s): Chronic Lymphocytic Leukemia Research
2015 - Elsevier BV | Blood
Elizabeth A. LaRue, Matthew P. Zuellig, Michael D. Netherland, Mark A. Heilman, Ryan A. Thum,
Abstract Hybridization may stimulate the evolution of invasiveness in human‐impacted habitats if unique hybrid genotypes have higher fitness than parental genotypes. Human efforts to control invasive taxa frequently involve the intentional alteration of habitats, but few studies have considered whether hybridization can result in decreased sensitivity to control measures. Here, we investigate whether interspecific hybrids between introduced Eurasian watermilfoil ( M yriophyllum spicatum ) and native ...
Tópico(s): Wildlife Ecology and Conservation
2012 - Wiley | Evolutionary Applications
Joachim Berkefeld, Seemant Chaturvedi,
... Beyssen B, Branchereau A, Moulin T, Becquemin J, Larue V, Lievre M, Leys D, Bonneville J, Watelet J, Pruvo J, Albucher J, Viguier A, Piquet P, Garnier P, Viader F, Touze E, Giroud M, Hosseni H, Pillet J, Favrole P, Neau J, Ducrocq X; for the EVA-3S Investigators. Endarterectomy versus stenting in patients with ...
Tópico(s): Cardiovascular Health and Disease Prevention
2010 - Lippincott Williams & Wilkins | Stroke
Yannick Le Bris, Barbara Burroni, Marguerite Fournier, Morgane Cheminant, Sara Ek, Eva Hoster, Marie‐Hélène Delfau‐Larue, Clémentine Sarkozy, Mary Callanan, Benoît Tessoulin, David Chiron, Martin Dreyling, Mats Jerkeman, Steven Le Gouill, Olivier Hermine,
Tópico(s): Acute Myeloid Leukemia Research
2024 - Elsevier BV | Blood
Vincent Ribrag, Violaine Safar, Hanneke C. Kluin‐Nelemans, Lucie Obéric, Pierre Feugier, Olivier Casasnovas, Catherine Thiéblemont, Nicolas Daguindau, Gandhi Damaj, Wolfram Klapper, Eva Hoster, Ludwig Fischer von Weikersthal, Mathias Haenel, Marc André, María Gomes da Silva, Fernando Carcinero, Ana Marín‐Niebla, Michał Taszner, Jan Walewski, Rinske Boersma, Ilse Houtenbos, Marie‐Hélène Delfau‐Larue, Steven Le Gouill, Martin Dreyling,
Abstract Background: Mantle cell lymphoma (MCL) formally remains an incurable disease. After immunochemotherapy induction, rituximab (R) maintenance can prolong remission duration, but most patients are highly exposed to relapse. The chemotherapy-free combination of lenalidomide and rituximab combo (R2) has demonstrated its activity in MCL, but has never been used as maintenance after immunochemotherapy and never been compared to RM. In the MCL R2 Elderly clinical trial (EUDRACT: 2012-002542-20), we ...
Tópico(s): Cancer-related gene regulation
2021 - Elsevier BV | Blood
Arie J. van Noordwijk, G. de Jong,
... Nigel G. Yoccoz, Paul Acker, Matthieu Authier, Benjamin Larue, Christie Le Coeur, Kaitlin R. Macdonald, Alex Nicol‐ ... 291–301.https://doi.org/10.1086/717639Benjamin Larue, Fanie Pelletier, Marco Festa-Bianchet A multivariate perspective ...
Tópico(s): Avian ecology and behavior
1986 - University of Chicago Press | The American Naturalist
2021 - Presses Universitaires De France | Cités
Jiří Raboch, Lucie Kališová, Alexander Nawka, Eva Kitzlerová, Georgi Onchev, Anastasia Karastergiou, Lorenza Magliano, Algirdas Dembinskas, Andrzej Kiejna, Francisco Torres-Gonzales, Lars Kjellin, Stefan Priebe, Thomas Kallert,
... Praxis 34(suppl 2):S233–S240, 2007Google Scholar32. Larue C, Dumais A, Ahern E, et al: Factors ...
Tópico(s): Emergency and Acute Care Studies
2010 - American Psychiatric Association | Psychiatric Services
Jiří Raboch, Lucie Kališová, Alexander Nawka, Eva Kitzlerová, Georgi Onchev, Anastasia Karastergiou, L. Magliano, Algirdas Dembinskas, Andrzej Kiejna, Francisco Torres-Gonzales, Lars Kjellin, Stefan Priebe, Thomas Kallert,
... Praxis 34(suppl 2):S233–S240, 2007Google Scholar32. Larue C, Dumais A, Ahern E, et al: Factors ...
Tópico(s): Ethics and Legal Issues in Pediatric Healthcare
2010 - American Psychiatric Association | Psychiatric Services
... https://doi.org/10.1111/1365-2435.14108Benjamin Larue, Fanie Pelletier, Marco Festa-Bianchet Determinants of spring ... 2021): 2726–2749.https://doi.org/10.1111/eva.13320Mark C. Belk, Peter J. Meyers, J. Curtis ...
Tópico(s): Marine and coastal plant biology
1966 - University of Chicago Press | The American Naturalist
Olivier Hermine, Eva Hoster, Jan Walewski, André Bosly, Stephan Stilgenbauer, Catherine Thiéblemont, Michał Szymczyk, Réda Bouabdallah, Michael Kneba, Michael Hallek, Gilles Salles, Pierre Feugier, Vincent Ribrag, Josef Birkmann, Roswitha Forstpointner, Corinne Haïoun, Mathias Hänel, Olivier Casasnovas, Jürgen Finke, Norma Peter, Kamal Bouabdallah, Catherine Sebban, Thomas Fischer, Ulrich Dührsen, Bernd Metzner, Georg Maschmeyer, Lothar Kanz, Christian Schmidt, Richard Delarue, Nicole Brousse, Wolfram Klapper, Elizabeth Macintyre, Marie‐Hélène Delfau‐Larue, Christiane Pott, Wolfgang Hiddemann, Michael Unterhalt, Martin Dreyling,
Background Mantle cell lymphoma is characterised by a poor long-term prognosis. The European Mantle Cell Lymphoma Network aimed to investigate whether the introduction of high-dose cytarabine to immunochemotherapy before autologous stem-cell transplantation (ASCT) improves outcome. Methods This randomised, open-label, parallel-group, phase 3 trial was done in 128 haemato-oncological hospital departments or private practices in Germany, France, Belgium, and Poland. Patients aged 65 years or younger ...
Tópico(s): Chronic Lymphocytic Leukemia Research
2016 - Elsevier BV | The Lancet
R. Chelsea Nagy, Jennifer K. Balch, Erin K. Bissell, Megan E. Cattau, Nancy F. Glenn, Benjamin S. Halpern, Nayani Ilangakoon, Brian R. Johnson, Maxwell B. Joseph, Sergio Marconi, Catherine O’Riordan, James Sanovia, Tyson L. Swetnam, William R. Travis, Leah Wasser, Elizabeth Woolner, Phoebe L. Zarnetske, Mujahid Abdulrahim, J. Adler, Grenville Barnes, Kristina J. Bartowitz, Rachael E. Blake, Sara Bombaci, Julien Brun, Jacob D. Buchanan, K. Dana Chadwick, Melissa Chapman, Steven Chong, Y. Anny Chung, Jessica R. Corman, Jannelle Couret, Erika Crispo, Thomas G. Doak, Alison Donnelly, Katharyn Duffy, Kelly Dunning, Sandra M. Durán, Jennifer W. Edmonds, Dawson Fairbanks, Andrew J. Felton, Christopher Florian, Daniel Gann, Martha Gebhardt, Nathan S. Gill, Wendy K. Gram, Jessica Guo, Brian J. Harvey, Katherine Hayes, Matthew R. Helmus, Robert T. Hensley, Kelly L. Hondula, Tao Huang, Wiley J. Hundertmark, Virginia Iglesias, Pierre-André Jacinthe, Lara S. Jansen, Marta A. Jarzyna, Tiona M. Johnson, Katherine D. Jones, Megan A. Jones, Michael G. Just, Youssef Kaddoura, Aurora K. Kagawa‐Vivani, Aleya Kaushik, Adrienne B. Keller, Katelyn King, Justin Kitzes, Michael J. Koontz, Paige V. Kouba, Wai‐Yin Kwan, Jalene M. LaMontagne, Elizabeth A. LaRue, Daijiang Li, Bonan Li, Yang Lin, Daniel Liptzin, William Alex Long, Adam L. Mahood, Samuel S. Malloy, Sparkle L. Malone, Joseph McGlinchy, Courtney L. Meier, Brett A. Melbourne, Nathan Mietkiewicz, Jeffery Morisette, Moussa Moustapha, Chance Muscarella, John Musinsky, Ranjan Muthukrishnan, Kusum Naithani, Merrie Beth Neely, Kari Norman, Stephanie M. Parker, Mariana Perez Rocha, Laís Petri, Colette Ramey, Sydne Record, Matthew W. Rossi, Michael Sanclements, Victoria Scholl, Anna K. Schweiger, Bijan Seyednasrollah, Debjani Sihi, Kathleen R. Smith, Eric R. Sokol, Sarah A. Spaulding, Anna I. Spiers, Lise A. St. Denis, Anika P. Staccone, Kaitlin Stack Whitney, Diane M. Stanitski, Eva Stricker, Thilina D. Surasinghe, Sarah K. Thomsen, Patrisse M. Vasek, Xiaolu Li, Di Yang, Rong Yu, Kelsey M. Yule, Kai Zhu,
Abstract It is a critical time to reflect on the National Ecological Observatory Network (NEON) science to date as well as envision what research can be done right now with NEON (and other) data and what training is needed to enable a diverse user community. NEON became fully operational in May 2019 and has pivoted from planning and construction to operation and maintenance. In this overview, the history of and foundational thinking around NEON are discussed. A framework of open science is described ...
Tópico(s): Scientific Computing and Data Management
2021 - Wiley | Ecosphere
Vincent Ribrag, Violaine Safar, Hanneke C. Kluin‐Nelemans, Lucie Obéric, Pierre Feugier, Olivier Casasnovas, Catherine Thiéblemont, Nicolas Daguindau, Gandhi Damaj, Eva Hoster, Ludwig Fischer von Weikersthal, Mathias Hänel, Marc André, María Gomes da Silva, Ana Marín‐Niebla, Michał Taszner, Jan Walewski, Rinske Boersma, Marie‐Hélène Delfau‐Larue, Steven Le Gouill, Martin Dreyling,
Background: Mantle cell lymphoma (MCL) formally remains an incurable disease. Recent trials in younger patients have demonstrated the benefit of a cytarabin-containing induction (Hermine, JCO 2022) and a rituximab (Le Gouill, NEJM 2017) as well as a lenalidomide maintenance (Ladetto, Lancet Haematol 2021). The MCL-R2 elderly trial investigated whether an induction with intermediate dose of cytarabine improves long term outcome over R-CHOP alone in elderly patients (>60 yrs). In addition, responders ...
Tópico(s): Lymphoma Diagnosis and Treatment
2023 - Elsevier BV | Blood
Christiane Pott, Marie‐Hélène Delfau‐Larue, Kheïra Beldjord, Elizabeth Macintyre, Sebastian Böettcher, Vahid Asnafi, Reiner Siebert, Anne Plonquet, Evelyne Callet‐Bauchut, Wolfram Klapper, Felix Berger, Michael Unterhalt, Martin Dreyling, Hanneke C. Kluin‐Nelemans, Eva Hoster,
Tópico(s): Systemic Lupus Erythematosus Research
2011 - Elsevier BV | Annals of Oncology