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Artigo Acesso aberto Revisado por pares

Xu Wang, Wei Cao, Jianjun Zhang, Ming Yan, Qin Xu, Xiangbing Wu, Lixin Wan, Zhiyuan Zhang, Chenping Zhang, Xing Qin, Meng Xiao, Dongxia Ye, Yuyang Liu, Ze‐Guang Han, Shaomeng Wang, Li Mao, Wenyi Wei, Wantao Chen,

Abstract Enhancer of zeste homolog 2 ( EZH 2) has been characterized as a critical oncogene and a promising drug target in human malignant tumors. The current EZH 2 inhibitors strongly suppress the enhanced enzymatic function of mutant EZH 2 in some lymphomas. However, the recent identification ... a PRC 2‐ and methyltransferase‐independent role of EZH 2 indicates that a complete suppression of all oncogenic functions of EZH 2 is needed. Here, we report a unique EZH 2‐targeting strategy by identifying a gambogenic acid ( ...

Tópico(s): Histone Deacetylase Inhibitors Research

2017 - Springer Nature | The EMBO Journal

Artigo Acesso aberto Revisado por pares

Jian Bai, Miao Ma, Mingjun Cai, Feifei Xu, Jiaxiang Chen, Guolan Wang, Xiaoming Shuai, Kaixiong Tao,

Abstract Objectives Enhancer of zeste homologue 2 ( EZH 2) is crucially involved in epigenetic silencing by acting as a histone methyltransferase. Although EZH 2 is overexpressed in many cancers and is ... malignant cell proliferation and invasion, the role of EZH 2 in senescence induced by DNA damage has ... study, we sought to explore the outcome of EZH 2 depletion along with exposure of doxorubicin ( DOX ), ... achieved in gastric cancer cells by DOX treatment. EZH 2 was downregulated by transfection with siRNA or ...

Tópico(s): Genomics and Chromatin Dynamics

2014 - Wiley | Cell Proliferation

Artigo Revisado por pares

Koshi Mimori, Kazuhiko Ogawa, Masahiro Okamoto, Tomoya Sudo, Hiroshi Inoue, Masaki Mori,

Enhancer of zeste homolog 2 (EZH-2) is a polycomb group (PcG) protein, and the clinical significance of this protein has not yet been determined in colorectal ... CRC cases have focused on the interaction between EZH-2 and histone deacetylase-1 (HDAC-1).We ... time RT-PCR to evaluate the expression of EZH-2 mRNA quantitatively in tumour and normal tissue ... order to compare its levels with those of EZH-2.Among the CRC cases, 32 patients whose tumour tissue showed overexpression of EZH-2 also had a significantly worse prognosis than ...

Tópico(s): Histone Deacetylase Inhibitors Research

2005 - Elsevier BV | European Journal of Surgical Oncology

Artigo Acesso aberto Revisado por pares

Makoto Nakagawa, Shuhei Fujita, Takuo Katsumoto, Kazutsune Yamagata, Yoko Ogawara, Ayuna Hattori, Yuki Kagiyama, Daisuke Honma, Kazushi Araki, Tatsuya Inoue, Ayako Kato, Koichiro Inaki, Chisa Wada, Yoshimasa Ono, Masahide Yamamoto, Osamu Miura, Yasuharu Nakashima, Issay Kitabayashi,

... expressed higher levels of enhancer of zeste homolog ( EZH ) 1 and EZH 2 , which encode the catalytic subunits of Polycomb ... PRC 2), than non‐ SP cells, suggesting that EZH 1 as well as EZH 2 contributes to the stemness maintenance of the MM cells and that targeting both EZH 1/2 is potentially a significant therapeutic approach ... eradicating myeloma stem cells. A novel orally bioavailable EZH 1/2 dual inhibitor, OR ‐S1, effectively eradicated ... had a greater antitumor effect than a selective EZH 2 inhibitor in vitro and in vivo, including ...

Tópico(s): Microtubule and mitosis dynamics

2018 - Wiley | Cancer Science

Artigo Revisado por pares

Aya Shinozaki‐Ushiku, Tetsuo Ushiku, Shigeki Morita, Masaki Anraku, Jun Nakajima, Masashi Fukayama,

... utility and prognostic significance of BAP 1 and EZH 2 in malignant mesothelioma. Methods and results The expression of BAP 1 and EZH 2 was investigated by immunohistochemistry in 32 malignant ... hyperplasia ( n = 18). BAP 1 loss and high EZH 2 expression were observed in 17 (53%) and ... benign lesions showed BAP 1 loss or high EZH 2 expression. The combination of BAP 1 loss and high EZH 2 expression as markers to differentiate epithelioid/biphasic ... asbestos exposure, treatment, histology, and BAP 1 or EZH 2 expression. Survival analysis revealed that BAP 1 ...

Tópico(s): Renal and related cancers

2016 - Wiley | Histopathology

Artigo Acesso aberto Revisado por pares

Xian‐Li Ma, Shengjin Qi, Zhenying Duan, Hongzhan Liao, Baohua Yang, Wenbo Wang, Jie Tan, Qinghua Li, Xuewei Xia,

... between Lnc RNA LOC 554202, miR‐31 and EZH 2 was elucidated in chordoma. Materials and methods The levels of LOC 554402, miR‐31, EZH 2, RNF 144B, and epithelial‐mesenchymal transition ( EMT ) ... to analyze the interaction between LOC 554202 and EZH 2. Animal tumour xenografts were generated, and qRT ‐ PCR was performed to investigate EZH 2, miR‐31, and RNB 144B expression on ... proliferation, migration, and invasion of chordoma cells. Unexpectedly, EZH 2 as a binding protein of LOC 554202, ... effects of knockdown of LOC 554202, which inhibited EZH 2/miR‐31 to activate the oncogene RNF ...

Tópico(s): Musculoskeletal synovial abnormalities and treatments

2017 - Wiley | Cell Proliferation

Artigo Revisado por pares

Anna Maria Athanassiadou, Angelos Tsipis, Efstratios Patsouris, Maria Gonidi, P. Nicolopoulou‐Stamati, George Chelidonis, Pauline Athanassiadou,

... polycomb group protein enhancer of zeste homologue 2 (EZH 2) has been reported as a marker of ... to investigate the correlation between the expression of EZH 2 with p53 and Ki-67 expression and ... investigated in order to identify the expression of EZH 2, Ki-67 and p53 in imprint smears ... Follow-up was available for all patients. Results: EZH 2 was expressed in 64% of the cases ... nucleus. Univariate analysis revealed a strong association between EZH 2 protein expression and tumor grade and size, ... lymph node metastasis was the main predictor for EZH 2 expression. Decreased patient survival was also significantly ...

Tópico(s): Genomics and Chromatin Dynamics

2011 - Karger Publishers | Acta Cytologica

Artigo Acesso aberto Revisado por pares

Fahim Ahmad, Shruti Patrick, Touseef Sheikh, Vikas Sharma, Pankaj Pathak, Prit Benny Malgulwar, Anupam Kumar, Shanker Datt Joshi, Chitra Sarkar, Ellora Sen,

... Elevated expression of enhancer of zeste homolog 2 ( EZH 2), a histone H3K27 methyltransferase, was observed in ... mutations. Given the known involvement of TERT and EZH 2 in glioma progression, the correlation between the ... pharmacologically or through genetic manipulation not only decreased EZH 2 expression, but also (i) abrogated FASN levels, ( ... TERT and FASN levels upon si RNA ‐mediated EZH 2 knockdown indicated a positive correlation between TERT and EZH 2. Interestingly, ATM kinase inhibitor rescued TERT inhibition‐ ...

Tópico(s): Telomeres, Telomerase, and Senescence

2017 - Wiley | Journal of Neurochemistry

Artigo Revisado por pares

Le Ying, Feng Yan, Bryan R.G. Williams, Ping Xu, Xin Li, Yueling Zhao, Yiqun Hu, Yuefei Wang, Dakang Xu, Jing Dai,

... levels of the enhancer of zeste homologue 2 ( EZH 2) were significantly higher in CRC tissues compared ... lines exhibited differing expression of levels of the EZH 2 protein. In RKO cells, EGCG and the EZH 2 inhibitor GSK 343 exhibited similar inhibitory efficacy ... by the loss of the enzymatic function of EZH 2. EGCG and GSK 343 were found to ... the growth of RKO cells in lower concentrations. EZH 2‐correlated genes were enriched in the cell ... phase in RKO cell cycle, suggesting EGCG and EZH 2 inhibitor share a common mechanism of action ...

Tópico(s): Tannin, Tannase and Anticancer Activities

2017 - Wiley | Clinical and Experimental Pharmacology and Physiology

Artigo Acesso aberto Revisado por pares

Muyang Ding, Hang Zhang, Zhen Li, Cuili Wang, Jasmine Chen, Liyun Shi, Dakang Xu, Yane Gao,

Summary Enhancer of zeste 2 ( EZH 2), a polycomb histone methyltransferase, is overexpressed in various cancers, including cervical cancer. Gene expression analysis revealed that increased expression of EZH 2 is associated with cervical cancer progression, particularly ... cancer. However, the specific molecular mechanisms by which EZH 2 contributes to the development of cervical cancer remain largely unknown. Recently, an EZH 2 inhibitor was reported to selectively inhibit trimethylated ... found that GSK 343 (a specific inhibitor of EZH 2 methyltransferase) induces phenotypic reprogramming of cancer cells ...

Tópico(s): Cancer-related gene regulation

2015 - Wiley | Clinical and Experimental Pharmacology and Physiology

Artigo Acesso aberto Revisado por pares

Taichi Takashina, Ichiro Kinoshita, Junko Kikuchi, Yasushi Shimizu, Jun Sakakibara‐Konishi, Satoshi Oizumi, Masaharu Nishimura, Hirotoshi Dosaka‐Akita,

... others have previously shown that the histone methyltransferase EZH 2, the catalytic subunit of polycomb repressive complex ... small‐cell lung cancer ( NSCLC ) and that an EZH 2 inhibitor, 3‐deazaneplanocin A, inhibits the proliferation of NSCLC cells. Transcriptional silencing by EZH 2 was recently shown to be required for ... modestly increased histone acetylation, and the depletion of EZH 2 and other PRC 2 proteins. The co‐ ... results suggest that the combined pharmacological targeting of EZH 2 and HDAC s may provide more effective ...

Tópico(s): Cancer-related gene regulation

2016 - Wiley | Cancer Science

Artigo Acesso aberto Revisado por pares

Koki Ueda, Akihide Yoshimi, Yuki Kagoya, Satoshi Nishikawa, Víctor E. Márquez, Masahiro Nakagawa, Mineo Kurokawa,

... ep). Therefore, we investigated the therapeutic potential of EZH 2 inhibition in mixed lineage leukemia ( MLL ) fusion leukemia. Intriguingly, EZH 2 inhibition by DZN ep or sh RNA ... with DZN ep. Chromatin immunoprecipitation assays demonstrated that EZH 2 was highly enriched around the transcription‐start‐ ... supposed to be responsible for the recruitment of EZH 2, our data also suggest that there may ... transduced cells. In summary, our findings show that EZH 2 is a potential therapeutic target of MLL ...

Tópico(s): Genomics and Chromatin Dynamics

2014 - Wiley | Cancer Science

Artigo Acesso aberto Revisado por pares

Zhengshi Wang, Jiaqi Dai, Jie Yan, Yun Zhang, Zhiqiang Yin,

... we revealed that enhancer of zeste homolog 2 ( EZH 2) was the direct target for miR‐124/ ... sorafenib resistant cells regained sensitivity for sorafenib by EZH 2 intervention with miR‐124/506 overexpression or EZH 2 inhibitor treatment in vitro and in vivo, ... levels. Therefore, we conclude that the suppression of EZH 2 represents a potential target for thyroid carcinoma ...

Tópico(s): Glutathione Transferases and Polymorphisms

2019 - Wiley | Journal of Cellular and Molecular Medicine

Artigo Revisado por pares

Shuangping Guo, Qing-Xian Bai, Joseph Rohr, Yingmei Wang, Yang Liu, Kaixuan Zeng, Kangjie Yu, Xiumin Zhang, Zhe Wang,

... difficult to diagnose and treat. The histone methyltransferase EZH 2 was reported to be involved in the ... cases of primary CNS DLBCL and expression of EZH 2 and Y641 mutation were assessed. The tumor ... MYC co‐expression were associated with poor prognosis. EZH 2 was strongly expressed in all 33 cases ... no association was found between the level of EZH 2 expression and outcomes of patients. In summary, ... primary CNS DLBCL are described. Strong expression of EZH 2 in all the primary CNS DLBCL and ...

Tópico(s): Glioma Diagnosis and Treatment

2016 - Wiley | Apmis

Artigo Acesso aberto Revisado por pares

Xiaobo Cai, Zhenghong Li, Qidi Zhang, Qu Yin, Mingyi Xu, Xinjian Wan, Lungen Lu,

... via the SMAD 2/ BRD 4/C‐ MYC / EZH 2 pathway by enhancing the SMAD 3‐ BRD ... C‐ MYC promoter and CMY ‐C to the EZH 2 promoter, thereby inducing profibrogenic gene expression in ... SMA , SMAD 3, BRD 4, C‐ MYC , and EZH 2 in liver tissue were increased. Taken together, ...

Tópico(s): Chromatin Remodeling and Cancer

2018 - Wiley | Journal of Cellular and Molecular Medicine

Artigo Acesso aberto Revisado por pares

Sandra Martínez‐Canales, Miguel López de Rodas, Miriam Nuncia‐Cantarero, Raquel Páez, Eitan Amir, Balázs Győrffy, Atanasio Pandiella, Eva María Galán‐Moya, Alberto Ocaña,

... others. Of note, the histone‐lysine N‐methyltransferase ( EZH 2 ) and the ubiquitin‐conjugating enzyme E2C ( UBE ... 10% and 6% of tumors, respectively. Of note, EZH 2 and UBE 2C were identified as principal ... ovarian cancer with potential for therapeutic intervention including EZH 2 and UBE 2C .

Tópico(s): Histone Deacetylase Inhibitors Research

2018 - Wiley | Cancer Medicine

Revisão Acesso aberto Revisado por pares

Makoto Nakagawa, Issay Kitabayashi,

... methyltransferases enhancer of zeste homolog 1 and 2 ( EZH 1/2), which are subunits of polycomb repressive ... mutated or highly expressed in many hematological malignancies. EZH 2 has a dual function in tumorigenesis as ... suppressor gene, and targeting PRC 2, in particular EZH 1/2, for anticancer therapy has been extensively ... setting. Here, we review the oncogenic function of EZH 1/2 and introduce new therapeutic drugs targeting ...

Tópico(s): Cancer-related gene regulation

2018 - Wiley | Cancer Science

Artigo Acesso aberto Revisado por pares

Shanshan Ai, Xianhong Yu, Yumei Li, Yong Peng, Chen Li, Yanzhu Yue, Ge Tao, Chuanyun Li, William T. Pu, Aibin He,

... and Results: Heart development was normal in Ezh1 −/− ( Ezh 1 knockout) and Ezh2 f/f ::cTNT −Cre ( Ezh 2 knockout) embryos. Ablation of both genes in ... were upregulated in a manner consistent with total EZH dose. In neonatal heart regeneration, Ezh1 was required, ... but not EZH2 restored neonatal heart regeneration in Ezh 1 knockout. In myocardial infarction performed outside of ...

Tópico(s): Genetics and Neurodevelopmental Disorders

2017 - Lippincott Williams & Wilkins | Circulation Research

Artigo Acesso aberto Revisado por pares

Yongjun Wang, Wei Xiang, Miao Wang, Tao Huang, Xingyuan Xiao, Liang Wang, Dan Tao, Liyun Dong, Fuqing Zeng, Guosong Jiang,

... inhibition of the enhancer of zeste homologue 2 ( EZH 2) expression, whereas miR ‐101 expression was up‐ ... of miR ‐101 restored this decreased expression of EZH 2 and suppressed the inhibitory effect of GA ... induced apoptosis by down‐regulating the expression of EZH 2 induced by miR ‐101. Thus, the combination ...

Tópico(s): Carbohydrate Chemistry and Synthesis

2013 - Wiley | British Journal of Pharmacology

Artigo Revisado por pares

Anna‐Maria Athanassiadou, Andreas C. Lazaris, Efstratios Patsouris, Angelos Tsipis, George Chelidonis, Kyriaki Aroni,

... 2 (COX-2), enhancer of zeste homolog 2 (EZH-2), and p53 in actinic keratosis (AK) and ... reaction (χ2 = 29.924, P < 0.0001). For EZH-2 immunostaining, a weak or no reaction was ... P = 0.003). COX-2, p53, but mainly EZH-2 immune expression seems to be strongly associated ...

Tópico(s): Inflammatory mediators and NSAID effects

2012 - Lippincott Williams & Wilkins | American Journal of Dermatopathology

Artigo Acesso aberto Revisado por pares

Yu Xiong, Kuang Wei, Shi-Gang Lu, Hua Guo, Miaojing Wu, Minhua Ye, Lei Wu,

... binding with the enhancer of zeste homolog 2 ( EZH 2) using bisulfite sequencing PCR ( BSP ), epigenetically suppressing ... immunoprecipitation (Ch IP ) assays using antibody against to EZH 2. Taken together, our study indicated that HOXB ...

Tópico(s): RNA Research and Splicing

2018 - Wiley | Cancer Medicine

Artigo Acesso aberto Revisado por pares

Woo Kyun Bae, Keunsoo Kang, Ji Yu, Kyung Hyun Yoo, Valentina M. Factor, Kosuke Kaji, Matthias S. Matter, Snorri S. Thorgeirsson, Lothar Helmighausen,

... investigate the role of enhancer of zeste homolog (EZH) 1 and EZH2 in liver homeostasis, mice were ... Hennighausen, L. The methyltransferases enhancer of zeste homolog (EZH) 1 and EZH2 control hepatocyte homeostasis and regeneration. ...

Tópico(s): Renal and related cancers

2014 - Wiley | The FASEB Journal

Revisão Revisado por pares

Monika Lachner, Roderick J. O’Sullivan, Thomas Jenuwein,

... 2002; Müller et al., 2002) and its mammalian Ezh-Eed counterpart (Cao et al., 2002; Kuzmichev et ... H3-K27 but might also target H3-K9. Ezh/Eed-mediated nucleosome methylation increases in vitro binding ... candidate for initiating early methylation imprints is the Ezh-Eed complex, because both Ezh2(Mak et al., ...

Tópico(s): RNA modifications and cancer

2003 - The Company of Biologists | Journal of Cell Science

Revisão Acesso aberto Revisado por pares

Yawei Wang, Fang Gao, Meng Zhao, Bing Li, Dan Xing, Jie Wang, Yang Yang,

Abstract Enhancer of zeste 2 ( EZH 2), a key component of polycomb repressive complex 2 ( PRC 2), was of great importance in human cancer pathogenesis. Various studies examined the relationship between EZH 2 overexpression with the clinical outcome in patients ... eligible studies which quantitatively evaluated the relationship between EZH 2 overexpression and survival of patients with digestive ... n = 1461 patients) that evaluated the correlation between EZH 2 overexpression and survival in patients with digestive ...

Tópico(s): Pancreatic and Hepatic Oncology Research

2016 - Wiley | Journal of Cellular and Molecular Medicine

Artigo Acesso aberto Revisado por pares

Amit Gupta, Sweety Gupta, Rishit Mani, Prashant Durgapal, Bela Goyal, Deepak Rajput, Shalinee Rao, Puneet Dhar, Manoj Gupta, Sanjeev Kishore, Ravi Kant,

... p16 in 42% whereas Her 2 neu and EZH-2 were positive in 16% of patients each. ... Her2 neu, p53, p16, survivin, COX-2, and EZH-2 in GBC. Now the time has come, ...

Tópico(s): Cancer Mechanisms and Therapy

2021 - Medknow | Journal of Carcinogenesis

Artigo Acesso aberto Revisado por pares

Albert Chakona, Wilbert T. Kadye, Taurai Bere, Daniel N. Mazungula, Emmanuel Vreven,

... and Hippopotamyrus (Mormyridae)], in the Eastern Zimbabwe Highlands (EZH) freshwater ecoregion to explore the extent to which ... clusters within five currently recognised 'species' from the EZH ecoregion. Only one of these clusters represents a ...

Tópico(s): Fish Ecology and Management Studies

2018 - Pensoft Publishers | ZooKeys

Artigo Revisado por pares

Francesco Vasuri, Deborah Malvi, S. Bonora, Silvia Fittipaldi, Matteo Renzulli, Francesco Tovoli, Rita Golfieri, Luigi Bolondi, Antonia D’Errico,

... HSP 70) and enhancer of zeste homologue 2 ( EZH 2) in liver biopsies for the differential diagnosis ... gold standard. GS , GPC 3, HSP 70 and EZH 2 showed 16.6%, 10.7%, 28.8% ...

Tópico(s): Hepatitis B Virus Studies

2017 - Wiley | Histopathology

Artigo Acesso aberto Revisado por pares

Elena Bernasconi, Eugenio Gaudio, Pascale Lejeune, Chiara Tarantelli, Luciano Cascione, Ivo Kwee, Filippo Spriano, Andrea Rinaldi, Afua A. Mensah, Elaine Chung, Anastasios Stathis, Stephan Siegel, Norbert Schmees, Matthias Ocker, Emanuele Zucca, Bernard Haendler, Francesco Bertoni,

... Notably, BAY 1238097 presented in vitro synergism with EZH 2, mTOR and BTK inhibitors. In conclusion, the ... also indicate the use of combination schemes targeting EZH 2, mTOR and BTK alongside BET bromodomains.

Tópico(s): Histone Deacetylase Inhibitors Research

2017 - Wiley | British Journal of Haematology

Artigo Acesso aberto Revisado por pares

Weihua Zhang, Jun Lin, Peng Wang, Jian Sun,

... and protein levels of enhancer of zeste homolog (EZH) 1, a member of the EZH family that contributes to drug resistance in several ...

Tópico(s): Cancer-related molecular mechanisms research

2016 - Taylor & Francis | Journal of drug targeting

Artigo Revisado por pares

Shaorong Zhang, Guanli Zhang, Jingying Liu,

... Mechanistically, we verified that PVT 1 binds to EZH 2, recruits EZH 2 to the miR‐200b promoter, increases histone ...

Tópico(s): RNA modifications and cancer

2016 - Wiley | Apmis