Andrew Robson, William Culver, Phil Yates, Raj Bhopal, Bel Mooney, Andrew Pierce, DJM, Kirsty McLeod, Adam Sherwin Media Reporter, Frances Gibb Legal Editor, Simon Cronin, Christopher Hyde, Robert Thicknesse, David Rhys Jones, Richard Hobson, Michael Evans Defence Editor, Moyra Poole, Philip Howard, Carol Midgley, Christine Seib, Chris Haslett, James Bone, James Ducker, Clive Davis, Elizabeth Judge, Richard Irving, Gabrielle Starkey, Rosalind Renshaw, Carl Mortished, David Evans, Lisbon, Jeremy Whittle, Joe Joseph, Missouri, Ben Webster Transport Correspondent, Valerie Elliott Countryside Editor, Wendy Leigh, Hugh Berrington (Emeritus Professor of Politics), Sarah Bulter, Anthony Browne, T. J. Harris, Dominic Walsh, Ruth Gledhill, Tom Bawden, Gary Jacob, Michael Knipe, Jill Dupleix, Tim Reid, Angela Jameson Industrial Correspondent, Dan Sabbagh, Andrew Manzur, Andover, Jason Knight, A. W. Harrison-Barbet, Alan Hamilton, Stephen Farrell, Vesna Goldworthy, Michael Hamlyn, Roland Watson, Peter Davies, David Hands, Charles Bremner, Sara Lawrence, Ron Lewis, Alexander John Barber, David Charter, Petter Klinger, J. R. Havers-Strong, Caroline Merrell Banking Correspondent, Tony Halpin Education Editor, Gary Duncan Economics Editor, Michelle Braham, Lisa Armstrong, John Westerby, Rick Broadbent, Black Jack, Mark Henderson Science Correspondent, Sam Coates, Andrew Pierce and Daniel McGrory, Chris Ayres and Angela Jameson, Barb Garner, Rob Wright, Christopher Walford, Chris Saunders, Neil Harman Tennis Correspondent, Raymond Keene, Tom von Hatten, John Russell Taylor, Christine Buckley Industrial Editor, Rosemary Bennett Deputy Political Editor, Clifford Coonan, Chris Campling, Bronwen Maddox, Helen Rumbelow Political Correspondent, Patrick Hosking, Richard Owen, Nick Blandford, Nick Hasell, Veronica Harrison, Allan Friswell, Pamela Reynolds, Karan Homer, David Hands Rugby Correspondent, Peter Gooderham, Julian Muscat, Paul Simons, Adam Fresco, Rick Broadbent and Bill Edgar, Andrew Pierce, Sam Coates and Helen Nugent, James Doran, Jonathan Clayton, Andy Warhol, Marshall (Chairman), C. Mark Dixon, George Caulkin, Robert Richardson, Fred Bridgland, Caitlin Moran, Alan Lee, Peter Riddell, Alured Darlington, John Goodbody Sports News Correspondent, Niall Williams, Simon Jenkins, Jamie Whyte, Martin Waller, Chris Ayres, Dominic Walsh and Nic Hopkins, Alan Coren, Carl Mortished International Business Editor, Benedict Nightingale, Noel McGuinness, Lilly Evans, Bill Edgar, Alice Miles, Abigail Rayner, Alexandra Blair Education Correspondent, Peter Klinger, Sam Lister Health Correspondent, Patience Wheatcroft, Christopher Irvine, Virginia Matthews,
... February 1, 2005, aged 49 Sister Lucia Dos Santos The last of the child shepherds of the shrine of Fatima, whose miracle and secrets were deemed authentic by ...
2005 - Gale Group | TDA
Produção Nacional
Revisado por pares
Juliana dos Santos Vaz, Maria de Fátima Santos Maia, Paulo Augusto Ribeiro Neves, Thiago M. Santos, Luís Paulo Vidaletti, César G. Victora,
Abstract Monitoring indicators of breastfeeding practices is important to protect and evaluate the progress of breastfeeding promotion efforts. However, high‐income countries lack standardized methodology to monitor their indicators. We aimed to update and summarize nationally representative annual estimates of breastfeeding indicators in high‐income countries and to describe methodological issues pertaining to the data sources used. A review was conducted through population‐based surveys with nationally ...
Tópico(s): Child Nutrition and Feeding Issues
2021 - Wiley | Maternal and Child Nutrition
Produção Nacional
Revisado por pares
Paulo Augusto Ribeiro Neves, Juliana dos Santos Vaz, Maria de Fátima Santos Maia, Philip Baker, Giovanna Gatica‐Domínguez, Ellen Piwoz, Nigel Rollins, César G. Victora,
BackgroundPrevious analyses of trends in feeding indicators of children younger than 2 years have been limited to low-income and middle-income countries. We aimed to assess time trends in the consumption of different types of milk (breastmilk, formula, and animal milk) by children younger than 2 years from 2000 to 2019 at a global level.MethodsIn this time-series analysis, we combined cross-sectional data from 487 nationally representative surveys from low-income and middle-income countries and information ...
Tópico(s): Public Health and Nutrition
2021 - Elsevier BV | The Lancet Child & Adolescent Health
Produção Nacional
Revisado por pares
Bianca Ervatti Gama, Natália K Almeida de Oliveira, Mariano Zalis, José Maria de Souza, Fátima Santos, Cláudio Tadeu Daniel‐Ribeiro, Maria de Fátima Ferreira‐da‐Cruz,
Abstract Background The goal of the present study was the characterization of Plasmodium falciparum genes associated to malaria drug resistance ( pfcrt , pfdhfr and pfdhps) , in samples from two Brazilian localities. Methods Parasites from 65 P. falciparum samples were genotyped using nested-PCR and direct DNA sequencing. Results Six resistant sulphadoxine-pyrimethamine (SP) pfdhfr genotypes and one haplotype associated to SP sensitivity were detected. For pfcrt gene, SVMNT chloroquine (CQ)-resistant genotype ...
Tópico(s): Venomous Animal Envenomation and Studies
2009 - BioMed Central | Malaria Journal
Produção Nacional
Revisado por pares
Marinella Silva Laport, Paula Veronesi Marinho Pontes, Daniela Silva dos Santos, Juliana de Fátima Santos-Gandelman, Guilherme Ramos da Silva Muricy, Mathieu Bauwens, Marcia Giambiagi‐deMarval, Isabelle George,
Although antibiotic-resistant pathogens pose a significant threat to human health, the environmental reservoirs of the resistance determinants are still poorly understood. This study reports the detection of resistance genes (ermB, mecA, mupA, qnrA, qnrB and tetL) to antibiotics among certain culturable and unculturable bacteria associated with the marine sponge Petromica citrina. The antimicrobial activities elicited by P. citrina and its associated bacteria are also described. The results indicate ...
Tópico(s): Aquaculture disease management and microbiota
2016 - Springer Nature | Brazilian Journal of Microbiology
Produção Nacional
Revisado por pares
Lilian Rose Pratt-Riccio, Selma Sallenave-Sales, Joseli Oliveira-Ferreira, Bruno T da Silva, Monick Lindenmeyer Guimarães, Fátima Santos, Thatiane Santos de Simone, Mariza Gonçalves Morgado, Salvatore G. De-Simone, Maria de Fátima Ferreira‐da‐Cruz, Cláudio Tadeu Daniel‐Ribeiro, Mariano Zalis, Daniel Camus, Dalma Maria Banic,
Abstract Background The Plasmodium falciparum P126 protein is an asexual blood-stage malaria vaccine candidate antigen. Antibodies against P126 are able to inhibit parasite growth in vitro , and a major parasite-inhibitory epitope has been recently mapped to its 47 kDa N-terminal extremity (octamer repeat domain – OR domain). The OR domain basically consists of six octamer units, but variation in the sequence and number of repeat units may appear in different alleles. The aim of the present study was ...
Tópico(s): Invertebrate Immune Response Mechanisms
2008 - BioMed Central | Malaria Journal
Produção Nacional
Revisado por pares
Allan Erlikhman Medeiros Santos, Milene Sabino Lana, Ivo Eyer Cabral, Tiago Martins Pereira, Masoud Zare Naghadehi, Denise de Fátima Santos da Silva, Tatiana Barreto dos Santos,
A methodology to predict the stability status of mine rock slopes is proposed. Two techniques of multivariate statistics are used: principal component analysis and discriminant analysis. Firstly, principal component analysis was applied in order to change the original qualitative variables into quantitative ones, as well as to reduce data dimensionality. Then, a boosting procedure was used to optimize the resulting function by the application of discriminant analysis in the principal components. ...
Tópico(s): Rock Mechanics and Modeling
2018 - Springer Science+Business Media | Geotechnical and Geological Engineering
Produção Nacional
Ana Paula Guimarães da Costa Carvalho, Diego Pereira, Edvane Alcantara Borges, Giovane Pereira de Oliveira, Maria Caroline Nazaré Pinto dos Santos, Roberta Oliveira de Araújo Morais, Andreza Lopes Maia, Diene Conceição Poiares Aranha, Laine Celestino Pinto, Sylvia de Fátima Santos Guerra,
Os pesticidas organoclorados (PCOs) são poluentes orgânicos persistentes (POPs) que constituem uma grande fonte de contaminação da água, solo e ar. A exposição humana a eles pode ser um fator de risco para a diabetes mellitus tipo 2 (DM2), sendo essa associação atribuída a mecanismos de ação dos PCOs que possivelmente influenciam na homeostase da glicose. O objetivo do presente estudo é realizar uma revisão sistemática descritiva da literatura sobre a detecção de PCOs na água e a associação da exposição ...
Tópico(s): Effects and risks of endocrine disrupting chemicals
2019 - Editora Univates | Revista Destaques Acadêmicos
M. Fátima Santos, J. F. Mesquita,
The process of accumulation of secondary carotenoids (astaxanthin) in Haematococcus lacustris was analysed in the optical and electron microscopes. The more relevant results of this cytological study are the following: a. In motile cells, the lipochromes are spherical inclusions, initially of small size, and located in the perinuclear cytoplasm apparently in preferential correlation with E. R. Although without a true limiting biomembrane, these sudanophilic and osmiophilic inclusions do not easily ...
Tópico(s): Biocrusts and Microbial Ecology
1984 - International Society of Cytology | CYTOLOGIA
Produção Nacional
Revisado por pares
Maria Aparecida Rodrigues, Luiz Augusto Facchini, Elaine Thumé, Maria de Fátima Santos Maia,
This systematic review aimed to assess the effect of gender on the incidence of functional disability in the elderly. The search for publications in the MEDLINE, EMBASE, and ProQuest electronic databases from January 1990 to March 2008 identified 879 publications, from which 21 cohort studies were selected that evaluated gender as an independent variable and incidence of functional disability in elderly as the outcome. Review of the studies found that after adjusting for socioeconomic, health, and ...
Tópico(s): Health and Wellbeing Research
2009 - Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz | Cadernos de Saúde Pública
Produção Nacional
Revisado por pares
Vaneska Spinelli Reuters, Patrícia de Fátima Santos Teixeira, Patrícia dos Santos Vigário, Cloyra Almeida, Alexandre Buescu, Márcia Martins Ferreira, Mário Vaisman, Carmen Lúcia Natividade de Castro, Jaime Gold,
Background Neuromuscular abnormalities and low exercise tolerance are frequently observed in overt hypothyroidism, but it remains controversial if they can also occur in subclinical hypothyroidism (sHT). The aim of this study is to evaluate neuromuscular symptoms, muscle strength, and exercise capacity in sHT, compared with healthy euthyroid individuals. Methods A cross-sectional study was performed with 44 sHT and 24 euthyroid outpatients from a university hospital. Neuromuscular symptoms were questioned. ...
Tópico(s): Thyroid Cancer Diagnosis and Treatment
2009 - Elsevier BV | The American Journal of the Medical Sciences
Produção Nacional
Revisado por pares
Márcia Nascimento, Janeusa Primo, Achiléa Lisbôa Bittencourt, Isadora Cristina de Siqueira, Maria de Fátima Santos Paim de Oliveira, Roberto Meyer, Albert Schriefer, Sara Santos, Edgar M. Carvalho,
Summary Human T lymphotropic virus-type 1 (HTLV-1) is the causal agent of the HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), adult T cell leukaemia/lymphoma and infective dermatitis associated with HTLV-1 (IDH). Over-production of proinflammatory cytokines and an increase in HTLV-1 proviral load are features of HAM/TSP, but the immunological basis of IDH has not been established. In addition to severe cutaneous manifestations, the importance of IDH relies on the observation that ...
Tópico(s): Animal Disease Management and Epidemiology
2009 - Oxford University Press | Clinical & Experimental Immunology
Produção Nacional
Revisado por pares
Fábio Gonçalves Ferreira, Maurício Alves Ribeiro, Maria de Fátima Santos, José César Assef, Luiz Arnaldo Szutan,
Tópico(s): Organ Transplantation Techniques and Outcomes
2009 - Springer Science+Business Media | World Journal of Surgery
Lisa Redrup, Miguel R. Branco, Elizabeth R Perdeaux, Christel Krueger, Annabelle Lewis, Fátima Santos, Takashi Nagano, Bradley S. Cobb, Peter Fraser, Wolf Reik,
Long noncoding RNAs are implicated in a number of regulatory functions in eukaryotic genomes. The paternally expressed long noncoding RNA (ncRNA) Kcnq1ot1 regulates epigenetic gene silencing in an imprinted gene cluster in cis over a distance of 400 kb in the mouse embryo, whereas the silenced region extends over 780 kb in the placenta. Gene silencing by the Kcnq1ot1 RNA involves repressive histone modifications, including H3K9me2 and H3K27me3, which are partly brought about by the G9a and Ezh2 histone ...
Tópico(s): Epigenetics and DNA Methylation
2009 - The Company of Biologists | Development
Daniel Corcos, Michael J. Osborn, Louise S. Matheson, Fátima Santos, Xiangang Zou, Jennifer A. Smith, Gareth J. Morgan, Amanda Hutchings, M. Hamon, David Oxley, Marianne Brüggemann,
Abstract Russell bodies (RBs) are intracellular inclusions filled with protein aggregates. In diverse lymphoid disorders these occur as immunoglobulin (Ig) deposits, accumulating in abnormal plasma or Mott cells. In heavy-chain deposition disease truncated antibody heavy-chains (HCs) are found, which bear a resemblance to diverse polypeptides produced in Ig light-chain (LC)–deficient (L−/−) mice. In L−/− animals, the known functions of LC, providing part of the antigen-binding site of an antibody and ...
Tópico(s): Chronic Myeloid Leukemia Treatments
2009 - Elsevier BV | Blood
Fátima Santos, Brian Hendrich, Wolf Reik, Wendy Dean,
Tópico(s): Prenatal Screening and Diagnostics
2002 - Elsevier BV | Developmental Biology
Produção Nacional
Revisado por pares
Dalma Maria Banic, Anna Carla Goldberg, Lilian Rose Pratt-Riccio, Joseli Oliveira-Ferreira, Fátima Santos, Hélène Gras-Masse, Daniel Camus, Jorge Kalil, Cláudio Tadeu Daniel‐Ribeiro,
We investigated the relationships between class II human leukocyte antigens (HLA) and the antibody response to Plasmodium falciparum p126 protein and to its amino-terminal portion (Nt47) in 2 malaria-endemic villages in Brazil, Colina and Ribeirinha. All people from the endemic areas had anti-p126 antibodies, and the frequencies of anti-Nt47 antibodies were similar in both communities (66% for Colina and 75% for Ribeirinha). Typing of HLA showed that Colina and Ribeirinha groups had no significant ...
Tópico(s): Antimicrobial Peptides and Activities
2002 - American Society of Tropical Medicine and Hygiene | American Journal of Tropical Medicine and Hygiene
Wolf Reik, Fátima Santos, Wendy Dean,
Epigenetic modifications of DNA and chromatin are important for genome function during development and in adults. DNA and chromatin modifications have central importance for genomic imprinting and other aspects of epigenetic control of gene expression. In somatic lineages, modifications are generally stably maintained and are characteristic of different specialized tissues. The mammalian genome undergoes major reprogramming of modification patterns in germ cells and in the early embryo. Some of ...
Tópico(s): Genetics and Neurodevelopmental Disorders
2002 - Elsevier BV | Theriogenology
Wendy Dean, Fátima Santos, Wolf Reik,
Tópico(s): Prenatal Screening and Diagnostics
2003 - Elsevier BV | Seminars in Cell and Developmental Biology
Fátima Santos, Valeri Zakhartchenko, Miodrag Stojković, Antoine H.F.M. Peters, Thomas Jenuwein, Eckhard Wolf, Wolf Reik, Wendy Dean,
During differentiation, somatic nuclei acquire highly specialized DNA and chromatin modifications, which are thought to result in cellular memory of the differentiated state [1Bird A. DNA methylation patterns and epigenetic memory.Genes Dev. 2002; 16: 6-21Crossref PubMed Scopus (4995) Google Scholar]. Upon somatic nuclear transfer into oocytes, the donor nucleus may have to undergo reprogramming of these epigenetic marks in order to achieve totipotency. This may involve changes in epigenetic features ...
Tópico(s): Pluripotent Stem Cells Research
2003 - Elsevier BV | Current Biology
Produção Nacional
Revisado por pares
Luiz Augusto Facchini, Anaclaudia Gastal Fassa, Marinel Mór Dall’Agnol, Maria de Fátima Santos Maia,
O trabalho infantil é um fenômeno global de grandes proporções, especialmente em países em desenvolvimento. Estima-se que, em todo o mundo, 352 milhões de crianças e adolescentes menores de 18 anos são economicamente ativos, incluindo atividades remuneradas, trabalho não-pago, ilegal e no setor informal da economia. No Brasil, cerca de 9,3 milhões de crianças entre 10 e 17 anos trabalham. Os estudos sobre a contribuição econômica das crianças à renda familiar são escassos. Este artigo apresenta ...
Tópico(s): Poverty, Education, and Child Welfare
2003 - ASSOCIAÇÃO BRASILEIRA DE SAÚDE COLETIVA | Ciência & Saúde Coletiva
Wolf Reik, Fátima Santos, Kohzoh Mitsuya, Hugh D. Morgan, Wendy Dean,
Epigenetic asymmetry between parental genomes and embryonic lineages exists at the earliest stages of mammalian development. The maternal genome in the zygote is highly methylated in both its DNA and its histones and most imprinted genes have maternal germline methylation imprints. The paternal genome is rapidly remodelled with protamine removal, addition of acetylated histones, and rapid demethylation of DNA before replication. A minority of imprinted genes have paternal germline methylation imprints. ...
Tópico(s): Prenatal Screening and Diagnostics
2003 - Royal Society | Philosophical Transactions of the Royal Society B Biological Sciences
Produção Nacional
Revisado por pares
Maura C. Malcon, Ana Maria B. Menezes, Maria de Fátima Santos Maia, Moema Chatkin, César G. Victora,
OBJETIVO: Descrever a prevalência do tabagismo em adolescentes e os fatores associados ao tabagismo nesse grupo etário na América do Sul. MÉTODOS: Foram pesquisadas as bases de dados MEDLINE (1966-2002) e Literatura Latino-Americana e do Caribe em Ciencias da Saúde ("Lilacs") (1982-2002), além de documentos governamentais e não-governamentais e sites na Internet. Foram identificados 315 artigos, dos quais 45 foram considerados relevantes para o presente trabalho. RESULTADOS: Em todos países estudados, ...
Tópico(s): Smoking Behavior and Cessation
2003 - Pan American Health Organization | Revista Panamericana de Salud Pública
Produção Nacional
Revisado por pares
Maria de Fátima Santos Maia, Sônia Elisa Caregnato,
Estudo bibliométrico sobre redes de colaboração científica entre os professores do Programa de Pós-Graduação em Epidemiologia da Universidade Federal de Pelotas (PPGE/UFPel). As características de colaboração foram estudadas através das co-autorias dos artigos publicados em periódicos, no período entre 1991 e 2002. As análises revelaram que os professores publicam mais artigos em autoria compartilhada do que individual. Não foi encontrada relação entre o aumento da produtividade e um número maior ...
Tópico(s): Business and Management Studies
2008 - Universidade Federal de Minas Gerais, Escola de Ciência da Informação | Perspectivas em Ciência da Informação
Produção Nacional
Revisado por pares
Luiz Augusto Facchini, Roberto Xavier Piccini, Elaine Tomasi, Elaine Thumé, Vanessa Teixeira, Denise Silva da Silveira, Maria de Fátima Santos Maia, Fernando Vinholes Siqueira, Maria Aparecida Rodrigues, Vera Vieira Paniz, Alessander Osório,
O artigo apresenta a metodologia de Estudo de Linha de Base (ELB), que avaliou a efetividade da Estratégia Saúde da Família em comparação às unidades básicas de saúde tradicionais. A base do estudo foi composta por 41 municípios acima de 100 mil habitantes, 21 da Região Sul e vinte do Nordeste. Principal variável dependente e pressuposto da base amostral do ELB, a efetividade das ações programáticas das unidades básicas de saúde foi examinada na população de sua área de abrangência, por meio de inquérito ...
Tópico(s): Global Public Health Policies and Epidemiology
2008 - Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz | Cadernos de Saúde Pública
Produção Nacional
Revisado por pares
Denise Silva da Silveira, Luiz Augusto Facchini, Fernando Vinholes Siqueira, Roberto Xavier Piccini, Elaine Tomasi, Elaine Thumé, Suele Manjourany Silva, Aliteia Santiago Dilélio, Maria de Fátima Santos Maia,
Decentralization in Brazil's Unified National Health System is challenging the management capability at the local level. Municipalities are required to operate health teams, provide infrastructure, technology, and supplies for the health services, and organize the work process. An epidemiological survey assessed the management of work, education, information, and communication in primary care services in 41 municipalities with more than 100,000 inhabitants each in the Northeast and South of the ...
Tópico(s): Healthcare Systems and Reforms
2010 - Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz | Cadernos de Saúde Pública
Produção Nacional
Revisado por pares
Vera Maria Vieira Paniz, Anaclaudia Gastal Fassa, Maria de Fátima Santos Maia, Marlos Rodrigues Domingues, Andréa Dâmaso Bertoldi,
Medicine access is an important goal of medicine policy; however the evaluation of medicine access is a subject under conceptual and methodological development. The aim of this study was to describe quantitative methodologies to measure medicine access on household level, access expressed as paid or unpaid medicine acquisition.Searches were carried out in electronic databases and health institutional sites; within references from retrieved papers and by contacting authors.Nine papers were located. ...
Tópico(s): Health Systems, Economic Evaluations, Quality of Life
2010 - BioMed Central | BMC Health Services Research
Fátima Santos, Louise Hyslop, Petra Stojković, Christine Leary, Alison Murdoch, Wolf Reik, Miodrag Stojković, Mary Herbert, Wendy Dean,
It has long been appreciated that environmental cues may trigger adaptive responses. Many of these responses are a result of changes in the epigenetic landscape influencing transcriptional states and consequently altering phenotypes. In the context of human reproductive health, the procedures necessary for assisted reproduction may result in altered phenotypes by primarily influencing DNA methylation. Among the well-documented effects of assisted reproduction technologies (ART), imprinted genes appear ...
Tópico(s): Prenatal Screening and Diagnostics
2010 - Oxford University Press | Human Reproduction
Produção Nacional
Revisado por pares
Joana D’Arc Pereira Mascarenhas, Alexandre C. Linhares, Yvone Benchimol Gabbay, Clarissa Silva Lima, Sylvia de Fátima Santos Guerra, Luana da Silva Soares, Darleise de Souza Oliveira, Jackson Cordeiro Lima, Olinda Macêdo, José Paulo Gagliardi Leite,
Several reports have identified P[6] specificities in humans and in animals in different countries of the world, but few sequence data are available in public databases. In this work we have characterized the VP4 strains bearing P[6] specificity and NSP4 genotypes among diarrheic young children and diarrheic and non-diarrheic neonates from three studies previously conducted in Belém, Northern region of Brazil. As the to VP8* fragment, we observed a close relationship to both human prototypes of ...
Tópico(s): Viral Infections and Immunology Research
2007 - Elsevier BV | Virus Research
Aline V. Probst, Fátima Santos, Wolf Reik, Geneviève Almouzni, Wendy Dean,
Tópico(s): Genomic variations and chromosomal abnormalities
2007 - Springer Science+Business Media | Chromosoma