Arrate y Acosta, José Martin Félix de,
pt. 1. Llave del Nuevo mundo antemural de las Indias Occidentales : La Habana descripta : noticias de su fundación, aumentos y estdao / J.M.F. de Arrate y Acosta -- ...
0000 - Gale Group | Sabin
Miguel Díaz‐Hernández, Adriana G. Valera, María A. Morán, Pilar Gómez‐Ramos, Beatriz Álvarez-Castelao, José G. Castaño, Félix Hernández, José J. Lucas,
In Huntington's disease (HD), as in the rest of CAG triplet-repeat disorders, the expanded polyglutamine (polyQ)-containing proteins form intraneuronal fibrillar aggregates that are gathered into inclusion bodies (IBs). Since IBs contain ubiquitin and proteasome subunits, it was proposed that inhibition of proteasome activity might underlie pathogenesis of polyQ disorders. Recent in vitro enzymatic studies revealed the inability of eukaryotic proteasomes to digest expanded polyQ, thus suggesting that ...
Tópico(s): Mitochondrial Function and Pathology
2006 - Wiley | Journal of Neurochemistry
Silvia Valverde, María Ibáñez, José Bernal, Marı́a J. Nozal, Félix Hernández, José Bernal,
In this study, the feasibility of two sample treatments has been evaluated for the determination of seven neonicotinoid insecticides in honey from different botanical origins using ultra-high performance liquid chromatography coupled to tandem mass spectrometry (UHPLC-MS/MS). A solid phase extraction with a polymeric sorbent (Strata® X) is proposed for analyzing dark honeys, while a QuEChERS (quick, easy, cheap, effective, rugged and safe) approach is recommended for light honeys. Chromatographic analysis ( ...
Tópico(s): Bee Products Chemical Analysis
2018 - Elsevier BV | Food Chemistry
Tobías Engel, Raquel Gómez‐Sintes, Mariana Alves, Eva M. Jiménez‐Mateos, Marta Fernández‐Nogales, Amaya Sanz‐Rodriguez, James J. Morgan, Edward Beamer, Alberto Rodríguez-Matellán, Mark Dunleavy, Takanori Sano, Jesús Ávila, Miguel Medina, Félix Hernández, José J. Lucas, David C. Henshall,
Glycogen synthase kinase-3 (GSK-3) is ubiquitously expressed throughout the brain and involved in vital molecular pathways such as cell survival and synaptic reorganization and has emerged as a potential drug target for brain diseases. A causal role for GSK-3, in particular the brain-enriched GSK-3β isoform, has been demonstrated in neurodegenerative diseases such as Alzheimer's and Huntington's, and in psychiatric diseases. Recent studies have also linked GSK-3 dysregulation to neuropathological ...
Tópico(s): Mitochondrial Function and Pathology
2018 - Springer Nature | Cell Death and Disease
Marta Fernández‐Nogales, María Santos‐Galindo, Jesús Merchán‐Rubira, Jeroen J.M. Hoozemans, Alberto Rábano, Isidró Ferrer, Jesús Ávila, Félix Hernández, José J. Lucas,
Increased incidence of neuronal nuclear indentations is a well-known feature of the striatum of Huntington's disease (HD) brains and, in Alzheimer's disease (AD), neuronal nuclear indentations have recently been reported to correlate with neurotoxicity caused by improper cytoskeletal/nucleoskeletal coupling. Initial detection of rod-shaped tau immunostaining in nuclei of cortical and striatal neurons of HD brains and in hippocampal neurons of early Braak stage AD led us to coin the term "tau nuclear ...
Tópico(s): Prion Diseases and Protein Misfolding
2016 - Wiley | Brain Pathology
Félix Hernández, José J. Lucas, Jesús Ávila,
Glycogen synthase kinase 3 (GSK3) is a ubiquitously expressed serine/threonine kinase that plays a key role in the pathogenesis of Alzheimer's disease (AD). GSK3 phosphorylates tau in most serine and threonine residues hyperphosphorylated in paired h
Tópico(s): Prion Diseases and Protein Misfolding
2012 - IOS Press | Journal of Alzheimer s Disease
Félix Hernández, José M. Marín, Óscar J. Pozo, Juan V. Sancho, Francisco J. López, Ignacio Morell,
Abstract An overview is given on the presence and changes over time of pesticide residues in groundwater from the Valencia region, one of the most important citrus cultivation sites of southern Europe. A multiresidue LC-MS/MS method was applied for the screening of around 50 pesticides in 75 water samples collected during 2000. The herbicides simazine, terbuthylazine, bromacil, terbumeton, and diuron were the most frequently detected compounds. On the basis of compounds detected in these samples, ...
Tópico(s): Pharmaceutical and Antibiotic Environmental Impacts
2008 - Taylor & Francis | International Journal of Environmental & Analytical Chemistry
Jesús Ávila, Mar Pérez, Filip Lim, Alberto Gómez‐Ramos, Félix Hernández, José J. Lucas,
Tópico(s): Nuclear Receptors and Signaling
2004 - Springer Science+Business Media | Neurotoxicity Research
Miguel Díaz‐Hernández, Fernando Moreno‐Herrero, Pilar Gómez‐Ramos, María A. Morán, Isidró Ferrer, A. M. Baró, Jesús Ávila, Félix Hernández, José J. Lucas,
Huntington's disease (HD) and eight additional inherited neurological disorders are caused by CAG triplet-repeat expansions leading to expanded polyglutamine-sequences in their respective proteins. These triplet-CAG repeat disorders have in common the formation of aberrant intraneuronal proteinaceous inclusions containing the expanded polyglutamine sequences. These aggregates have been postulated to contribute to pathogenesis caused by conformational toxicity, sequestration of other polyglutamine- ...
Tópico(s): Neurological disorders and treatments
2004 - Society for Neuroscience | Journal of Neuroscience
Miguel Díaz‐Hernández, Ester Martín‐Aparicio, Jesús Ávila, Félix Hernández, José J. Lucas,
Tópico(s): Muscle Physiology and Disorders
2004 - Springer Science+Business Media | Neurotoxicity Research
Ratan V. Bhat, Yafeng Xue, Stefan von Berg, Sven Hellberg, Mats Ormö, Yvonne Nilsson, Ann‐Cathrin Radesäter, Eva Jerning, Per-Olof Markgren, Thomas Borgegård, Martin Nylöf, Alfredo Giménez-Cassina, Félix Hernández, José J. Lucas, Javier Dı́az-Nido, Jesús Ávila,
Glycogen synthase kinase 3 (GSK3) is a serine/threonine kinase that has been implicated in pathological conditions such as diabetes and Alzheimer's disease. We report the characterization of a GSK3 inhibitor, AR-A014418, which inhibits GSK3 (IC50 = 104 ± 27 nM), in an ATP-competitive manner (K i = 38 nM). AR-A014418 does not significantly inhibit cdk2 or cdk5 (IC50 > 100 μM) or 26 other kinases demonstrating high specificity for GSK3. We report the co-crystallization of AR-A014418 with the GSK3β protein and ...
Tópico(s): Alzheimer's disease research and treatments
2003 - Elsevier BV | Journal of Biological Chemistry
Félix Hernández, José I. Borrell, Carmen Guaza, Jesús Ávila, José J. Lucas,
Abstract Deregulation of glycogen synthase kinase‐3 (GSK‐3) activity in neurones has been postulated as a key feature in Alzheimer's disease (AD) pathogenesis. This was further supported by our recent characterization of transgenic mice that conditionally over‐express GSK‐3β in hippocampal and cortical neurones. These mice, designated Tet/GSK‐3β, showed many of the biochemical and cellular aspects of AD neuropathology such as tau hyperphosphorylation and somatodendritic localization, decreased nuclear ...
Tópico(s): Wnt/β-catenin signaling in development and cancer
2002 - Wiley | Journal of Neurochemistry
Filip Lim, Félix Hernández, José J. Lucas, Pilar Gómez‐Ramos, Mark Moran, Jesús Ávila,
The tauopathies, which include Alzheimer's disease (AD) and frontotemporal dementias, are a group of neurodegenerative disorders characterized by filamentous Tau aggregates. That Tau dysfunction can cause neurodegeneration is indicated by pathogenic tau mutations in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). To investigate how Tau alterations provoke neurodegeneration we generated transgenic mice expressing human Tau with four tubulin-binding repeats (increased by FTDP- ...
Tópico(s): Neuroscience and Neuropharmacology Research
2001 - Elsevier BV | Molecular and Cellular Neuroscience
Javier Catalán, Fernando Fabero, Maria Soledad Guijarro, Rosa M. Claramunt, María Dolores Santa María, María de la Concepción Foces‐Foces, F. H. Cano, José Elguero, R. Sastre,
... Santa Maria, Maria de la Concepcion Foces-Foces, Felix Hernandez Cano, Jose Elguero, and Roberto SastreCite this: J. Am. Chem. ...
Tópico(s): Organic Chemistry Cycloaddition Reactions
1991 - American Chemical Society | Journal of the American Chemical Society
Javier Catalán, Fernando Fabero, Maria Soledad Guijarro, Rosa M. Claramunt, Dolores Santa María, María de la Concepción Foces‐Foces, F. H. Cano, José Elguero, R. Sastre,
... Santa Maria, Maria de la Concepcion Foces-Foces, Felix Hernandez Cano, Jose Elguero, and Roberto SastreCite this: J. Am. Chem. ...
Tópico(s): CO2 Reduction Techniques and Catalysts
1990 - American Chemical Society | Journal of the American Chemical Society
J. A. S. Smith, Bernd Wehrle, Francisco Aguilar‐Parrilla, Hans‐Heinrich Limbach, María de la Concepción Foces‐Foces, F. H. Cano, José Elguero, André Baldy, M. Pierrot,
... Heinrich Limbach, Maria de la Concepcion Foces-Foces, Felix Hernandez Cano, Jose Elguero, Andre Baldy, Marcel Pierrot, and Cite this: ...
Tópico(s): Metal complexes synthesis and properties
1989 - American Chemical Society | Journal of the American Chemical Society
Mario Villa González, Laura Vallés‐Saiz, Ivó H. Hernández, Jesús Ávila, Félix Hernández, María José Pérez-Álvarez,
Abstract Ischemic stroke is a major cause of death and the first leading cause of long‐term disability worldwide. The only therapeutic strategy available to date is reperfusion and not all the patients are suitable for this treatment. Blood flow blockage or reduction leads to considerable brain damage, affecting both gray and white matter. The detrimental effects of ischemia have been studied extensively in the former but not in the latter. Previous reports indicate that preservation of white matter ...
Tópico(s): MicroRNA in disease regulation
2020 - Wiley | Glia
Félix Galindo-Hernández, José Manuel Domínguez, B. Portales-Martínez,
Newer catalysts for the methane reforming with H2S are designed, which are based on Fe2O3/γ-Al2O3, nanocrystalline γ-Al2O3 supports, and 1.0 to 6.0 wt% Fe. The main phases are identified as hematite and γ-Al2O3, with sizes of about 2–4 nm. The structural features are characterized by X-ray diffraction, Rietveld's Refinement and Radial Distribution Function analysis. The textural properties of these catalysts are determined by N2 sorption and surface fractal dimension calculations. Also, the electronic ...
Tópico(s): Catalysis and Hydrodesulfurization Studies
2015 - Elsevier BV | Journal of Power Sources
Nancy Ramírez‐Álvarez, Lorena M. Rios Mendoza, José Vinicio Macías‐Zamora, Lucero Oregel-Vázquez, Arturo Alvarez-Aguilar, Félix Augusto Hernández-Guzmán, José Luis Sánchez-Osorio, Charles J. Moore, Hortencia Silva‐Jiménez, Luis Felipe Navarro-Olache,
Microplastics (MPs) are ubiquitous and a threat to marine and freshwater environments. Effluent waters from secondary wastewater treatment plants (WWTPs) into Todos Santos Bay (TSB) were investigated as sources of MPs. MPs were detected in all analyzed matrices and presented variable morphologies. MPs from surface water samples (n = 18) varied from 0.01 to 0.70 plastic particles/m3 (pp/m3). Fragments (47 ± 23%) and fibers (47 ± 23%) were the most abundant particles found in the surface water samples. In sediment ...
Tópico(s): Marine Biology and Environmental Chemistry
2019 - Elsevier BV | The Science of The Total Environment
Pedro Molina, Mateo Alajarı́n, Carmen López‐Leonardo, Rosa M. Claramunt, María de la Concepción Foces‐Foces, F. H. Cano, Javier Catalán, José Luis García de Paz, José Elguero,
... Maria Claramunt, M. de la Concepcion Foces-Foces, Felix Hernandez Cano, Javier Catalan, Jose Luis G. De Paz, and Jose ElgueroCite this: ...
Tópico(s): Phosphorus compounds and reactions
1989 - American Chemical Society | Journal of the American Chemical Society
Sara Picó, Alberto Parras, María Santos‐Galindo, Julia Pose‐Utrilla, Margarita Castro, Enrique Fraga, Ivó H. Hernández, Ainara Elorza, Héctor Anta, Nan Wang, Laura Martí‐Sánchez, Eulàlia Belloc, Paula Garcia‐Esparcia, Juan José Garrido, Isidró Ferrer, Daniel Macías‐García, Pablo Mir, Rafael Artuch, Belén Pérez, Félix Hernández, Pilar Navarro, José Luis López-Sendón, Teresa Iglesias, Xia Yang, Raúl Méndez, José J. Lucas,
Altered CPEBs and mRNA polyadenylation lead to thiamine deficiency in the brains of patients and mice with Huntington’s disease.
Tópico(s): Parkinson's Disease Mechanisms and Treatments
2021 - American Association for the Advancement of Science | Science Translational Medicine
Natalia Chiquete‐Félix, José Manuel Hernández, José Alfredo Tirado Méndez, Armando Zepeda-Bastida, Alicia Chagolla‐López, Adela Mújica,
Glycolytic enzymes have, in addition to their role in energy production, other functions in the regulation of cellular processes. Aldolase A has been reported to be present in sperm, playing a key role in glycolysis; however, despite its reported interactions with actin and WAS, little is known about a non-glycolytic role of aldolase A in sperm. Here, we show that in guinea pig spermatozoa, aldolase A is tightly associated to cytoskeletal structures where it interacts with actin, WAS, and Arp2/3. ...
Tópico(s): Ovarian function and disorders
2009 - Bioscientifica | Reproduction
Lubertus Bijlsma, Elena Pitarch, Félix Hernández, Eddie Fonseca, José M. Marín, María Ibáñez, Tania Portolés, Andreu Rico,
The widespread use of pesticides, especially in agricultural areas, makes necessary to control their presence in surrounding surface waters. The current study was designed to investigate the occurrence and ecological risks of pesticides and their transformation products in a Mediterranean river basin impacted by citrus agricultural production. Nineteen sites were monitored in three campaigns distributed over three different seasons. After a qualitative screening, 24 compounds was selected for subsequent ...
Tópico(s): Pesticide Residue Analysis and Safety
2021 - Elsevier BV | Journal of Hazardous Materials
Marta Fernández‐Nogales, Jorge Rubén Cabrera, María Santos‐Galindo, Jeroen J.M. Hoozemans, Isidró Ferrer, Annemieke J.M. Rozemüller, Félix Hernández, Jesús Ávila, José J. Lucas,
An imbalance of tau isoforms containing either three or four microtubule-binding repeats causes frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17) in families with intronic mutations in the MAPT gene. Here we report equivalent imbalances at the mRNA and protein levels and increased total tau levels in the brains of subjects with Huntington's disease (HD) together with rod-like tau deposits along neuronal nuclei. These tau nuclear rods show an ordered filamentous ultrastructure ...
Tópico(s): Neurological disorders and treatments
2014 - Nature Portfolio | Nature Medicine
Tobías Engel, Félix Hernández, Jesús Ávila, José J. Lucas,
Glycogen synthase kinase-3 (GSK-3) is a ubiquitously expressed serine/threonine kinase that is particularly abundant in the CNS. Dysregulation of GSK-3 activity is believed to play a key role in the pathogenesis of CNS chronic disorders such as Alzheimer's disease (AD), bipolar disorder, and Huntington's disease, and of metabolic disorders such as type II diabetes. Accordingly, GSK-3 inhibitors have been postulated as therapeutic tools for these diseases. Interestingly, pathophysiological and pharmacological ...
Tópico(s): Neurological disorders and treatments
2006 - Society for Neuroscience | Journal of Neuroscience
Alberto Valera, Miguel Díaz‐Hernández, Félix Hernández, Zaira Ortega, José J. Lucas,
The main histopathological feature of Huntington's disease (HD) is the presence of protein aggregates that are gathered into inclusion bodies. So far the mechanisms that lead to inclusion formation as well as their role in the pathogenesis of HD are not totally understood. However, it is well established that inclusion bodies contain components of the ubiquitin-proteasome system. Accordingly, it has been postulated that impairment of this machinery can be one of the causes of this disorder. In this ...
Tópico(s): Mitochondrial Function and Pathology
2005 - SAGE Publishing | The Neuroscientist
Félix Hernández, Mar Pérez, José J. Lucas, Ana M. Mata, Ratan V. Bhat, Jesús Ávila,
Tauopathies, including Alzheimer's disease, are neurodegenerative disorders in which tau protein accumulates as a consequence of alterations in its metabolism. At least three different types of alterations have been described; in some cases, an aberrant mRNA splicing of tau exon 10 occurs; in other cases, the disorder is a consequence of missense mutations and, in most cases, aberrant tau hyperphosphorylation takes place. Glycogen synthase kinase-3 (GSK-3) has emerged as a key kinase that is able ...
Tópico(s): Cancer-related gene regulation
2004 - Elsevier BV | Journal of Biological Chemistry
Félix Hernández, Mar Pérez, José J. Lucas, Jesús Ávila,
Sulfo-glycosaminoglycans (sGAGs) are involved in the assembly of tau in at least a subpopulation of paired helical filaments (PHFs) in Alzheimer’s disease (AD). To further understand the role of sGAG molecules in the structure of PHFs, we isolated PHFs from patients with AD and treated them with heparinase. Immunoelectron microscopy and Western blotting (WB) were used later on to analyze the changes obtained. The heparinase treatment abolished Tau14 and AT8 immunodecoration (two N-terminal tau antibodies) ...
Tópico(s): Connective tissue disorders research
2002 - Elsevier BV | Brain Research
Francisco Aguilar‐Parrilla, Hans‐Heinrich Limbach, Concepción Foces‐Foces, F. H. Cano, Nadine Jagerovic, José Elguero,
... Aguilar-Parrilla, Hans-Heinrich Limbach, Concepcion Foces-Foces, Felix Hernandez Cano, Nadine Jagerovic, and Jose ElgueroCite this: J. Org. Chem. 1995, 60, 7, ...
Tópico(s): Magnetism in coordination complexes
1995 - American Chemical Society | The Journal of Organic Chemistry
Javier Catalán, Fernando Fabero, Rosa M. Claramunt, Dolores Santa María, María de la Concepción Foces‐Foces, F. H. Cano, M. Martínez‐Ripoll, José Elguero, R. Sastre,
... Santa Maria, M. de la Concepcion Foces-Foces, Felix Hernandez Cano, Martin Martinez-Ripoll, Jose Elguero, and Roberto SastreCite this: J. Am. Chem. ...
Tópico(s): Synthesis and biological activity
1992 - American Chemical Society | Journal of the American Chemical Society