Minglei Kang, Xuanfeng Ding, Yi Rong,
... proton beams.10, 11 Two innovative approaches, proton FLASH RT and proton arc RT, have emerged.8, 9 While both methods hold promise, I believe proton FLASH RT is the superior option. Proton FLASH RT is an innovative approach that delivers therapeutic doses ... response.17 The first clinical trial of proton FLASH RT was conducted on a group of 10 patients ... and safety using proton pencil beam scanning (PBS) FLASH RT. This body of evidence suggests that FLASH RT can provide substantial benefits over conventional RT methods, ...
Tópico(s): Radiation Effects in Electronics
2023 - Wiley | Journal of Applied Clinical Medical Physics
Hongyu Zhu, Dehuan Xie, Ying Wang, Runda Huang, Xi Chen, Yiwei Yang, Bin Wang, Yinglin Peng, Jianxin Wang, Dexin Xiao, Dai Wu, Chao‐Nan Qian, Xiaowu Deng,
... MV X-ray ultra-high dose rate radiotherapy (FLASH-RT) and conventional dose rate radiotherapy (CONV-RT). Materials/ ... administered 10 Gy abdominal 6 MV X-ray FLASH-RT (125 Gy/s) or CONV-RT (0.2 ... tissue damage and immune cell infiltration. Results Both FLASH-RT and CONV-RT significantly delayed tumor growth. Flow ... ratios were observed in the spleens of the FLASH-RT group than in the spleens of the non- ... group, but not in the spleens of the FLASH-RT group. Reduced intestinal damage, macrophage and neutrophil infiltration ...
Tópico(s): Effects of Radiation Exposure
2022 - Elsevier BV | Clinical and Translational Radiation Oncology
Barrett D. Allen, Yasaman Alaghband, Enikö A. Kramár, Ning Ru, Benoît Petit, Veljko Grilj, Michael S. Petronek, Casey Pulliam, Rachel Y Kim, Ngoc-Lien Doan, Janet E. Baulch, Marcelo A. Wood, Claude Bailat, Douglas R. Spitz, Marie‐Catherine Vozenin, Charles L. Limoli,
Ultrahigh dose-rate radiotherapy (FLASH-RT) affords improvements in the therapeutic index by minimizing normal tissue toxicities without compromising antitumor efficacy compared to conventional dose-rate ... CONV-RT). To investigate the translational potential of FLASH-RT to a human pediatric medulloblastoma brain tumor, we ... 6 mice exposed to hypofractionated (2 × 10 Gy, FLASH-RT or CONV-RT) whole brain irradiation and unirradiated ... neurological and cerebrovascular decrements.The neurological impact of FLASH-RT was analyzed over a 6-month follow-up. ...
Tópico(s): Cancer-related cognitive impairment studies
2022 - Oxford University Press | Neuro-Oncology
Pierre Montay‐Gruel, Munjal M. Acharya, Patrik Gonçalves Jorge, Benoît Petit, Ioannis Petridis, Philippe Fuchs, Ron Leavitt, Kristoffer Petersson, Maude Gondré, Jonathan Ollivier, Raphaël Moeckli, François Bochud, Claude Bailat, Jean Bourhis, Jean-François Germond, Charles L. Limoli, Marie‐Catherine Vozenin,
... than tenths of a second using FLASH radiotherapy (FLASH-RT), does not elicit neurocognitive deficits in mice. This ... investigating the antitumor efficacy and neuroprotective benefits of FLASH-RT 1-month after exposure, using a well-characterized ... the neuroprotective effects and optimized tumor treatments with FLASH-RT. Results: The capability of FLASH-RT to minimize the induction of radiation-induced brain ... glioblastoma growth for all tested regimens. Furthermore, only FLASH-RT was found to significantly spare radiation-induced cognitive ...
Tópico(s): Boron Compounds in Chemistry
2020 - American Association for Cancer Research | Clinical Cancer Research
Douglas R. Spitz, Garry R. Buettner, Charles L. Limoli,
... how FLASH ultra-high dose rate ionizing radiation (FLASH-RT; >40 Gy/s) may protect against normal tissue ... with the ultra-high dose rates used in FLASH-RT [ [2] Montay-Gruel P. Acharya M.M. Petersson ... Google Scholar ]. Our proposed mechanistic hypothesis for how FLASH-RT can minimize oxidative distress to normal tissue compared ... explaining the remarkable normal tissue sparing effects of FLASH-RT. The many estimations we made in this hypothesis ... our goal was to specifically emphasize that upon FLASH-RT a great deal, if not all, of the ...
Tópico(s): Advanced Radiotherapy Techniques
2019 - Elsevier BV | Radiotherapy and Oncology
Sarkar Siddique, Harry E. Ruda, James C. L. Chow,
... ultra-high dose rate (UHDR) radiation, known as FLASH RT, has shown promising results in reducing normal tissue toxicity while maintaining tumor control. However, implementing FLASH RT in clinical settings presents technical challenges, including limited ... in RT and has been investigated for optimizing FLASH RT. Various MC codes, such as EGSnrc, DOSXYZnrc, and ... optimize treatment plans. Accurate dosimetry is essential for FLASH RT, and radiation detectors play a crucial role in ... in ionization chambers to improve their accuracy in FLASH RT. Additionally, strip-segmented ionization chamber arrays have shown ...
Tópico(s): Radiation Detection and Scintillator Technologies
2023 - Multidisciplinary Digital Publishing Institute | Cancers
Yannick Poirier, Sina Mossahebi, S Becker, Brandon Koger, Junliang Xu, Narrotam Lamichhane, Peter G. Maxim, Amit Sawant,
... be considered does not hold when operated at FLASH‐RT dose rates (~200× clinical dose rate), where dose ... impact of converting a Varian 21EX linac to FLASH‐RT dose rates. Methods We performed a radiation survey ... activated linac components following a 1.8‐min FLASH‐RT delivery was also measured. Results When operated at ... such as during biology experiments, the 16 MeV FLASH‐RT electrons deliver ~10 µSv/h in the controlled ... 92 s, which corresponds in this bunker and FLASH‐RT beam to a 3180 Gy workload at isocenter, ...
Tópico(s): Nuclear Physics and Applications
2021 - Wiley | Medical Physics
Lorea Iturri, Annaïg Bertho, Charlotte Lamirault, Marjorie Juchaux, Cristèle Gilbert, Julie Espenon, Catherine Sébrié, Laurène Jourdain, Frédéric Pouzoulet, Pierre Verrelle, Ludovic De Marzi, Yolanda Prezado,
Purpose FLASH radiation therapy (FLASH-RT) is a promising radiation technique that uses ultrahigh doses of radiation to increase the therapeutic window of the treatment. FLASH-RT has been observed to provide normal tissue sparing ... to investigate the potential immune response generated by FLASH-RT in a high dose of proton therapy in ... and tumor microenvironment by flow cytometry. Results Proton FLASH-RT spared memory impairment produced by conventional high-dose ... immune response in the tumor. FLASH radiation therapy (FLASH-RT) is a promising radiation technique that uses ultrahigh ...
Tópico(s): Boron Compounds in Chemistry
2022 - Elsevier BV | International Journal of Radiation Oncology*Biology*Physics
Binwei Lin, Dan Huang, Feng Gao, Yiwei Yang, Dai Wu, Yu Zhang, Gang Feng, Tangzhi Dai, Xiaobo Du,
FLASH radiotherapy (FLASH-RT) is a novel radiotherapy technology defined as ultra-high dose rate (≥ 40 Gy/s) radiotherapy. The biological effects of FLASH-RT include two aspects: first, compared with conventional dose rate radiotherapy, FLASH-RT can reduce radiation-induced damage in healthy tissue, and second, FLASH-RT can retain antitumor effectiveness. Current research shows that mechanisms of the biological effects of FLASH-RT are related to oxygen. However, due to the short time of FLASH-RT, evidences related to the mechanisms are indirect, and ...
Tópico(s): Effects of Radiation Exposure
2022 - Frontiers Media | Frontiers in Oncology
S. Zhou, Dandan Zheng, Qiyong Fan, Ying Yan, Shuo Wang, Yu Lei, Abigail Besemer, Christina Zhou, Charles A. Enke,
... required by pulsed ultra‐high dose rate radiotherapy (FLASH RT) using dimensional analysis. Materials/methods In this study, ... induced transient hypoxia inside normal tissue cells during FLASH RT results in better normal tissue sparing over conventional ... above, we could estimate the required for pulsed FLASH RT through dimensional analysis. Results The estimated required for pulsed FLASH RT is proportional to the product of the oxygen ... with the dose rates observed in the recent FLASH RT experiments. Conclusions The introduced in this paper can ...
Tópico(s): Advanced MRI Techniques and Applications
2020 - Wiley | Medical Physics
Nolan Esplen, Marc S. Mendonca, Magdalena Bazalova‐Carter,
... normal tissue toxicity and similar tumor control for FLASH-RT when compared with conventional dose-rate RT. Subsequent ... been inundated with publications on FLASH therapies. Today, FLASH-RT is considered by some as having the potential to 'revolutionize radiotherapy'. FLASH-RT is considered by some as having the potential ... RT technique and to review existing publications on FLASH-RT in terms of its physical and biological aspects. ... drawbacks of radiation detectors suitable for dosimetry in FLASH-RT are presented. The biology section comprises a summary ...
Tópico(s): Radiation Detection and Scintillator Technologies
2020 - IOP Publishing | Physics in Medicine and Biology
Rémy Kinj, Olivier Gaide, Wendy Jeanneret‐Sozzi, Urania Dafni, Stéphanie Viguet‐Carrin, Enea Sagittario, Magdalini Kypriotou, Julie Chenal, F. Duclos, Marine Hebeisen, Teresa Falco, Reiner Geyer, Patrik Gonçalves Jorge, Raphaël Moeckli, Jean Bourhis,
... skin side effects. Low energy electron FLASH radiotherapy (FLASH-RT) is a new form of radiotherapy exploiting the ... pre-clinical studies, when compared to CONV-RT, FLASH-RT induced a robust, reproducible and remarkable sparing of ... In this context, we aim to prospectively evaluate FLASH-RT versus CONV-RT with regards to toxicity and ... selection, non-comparative, phase II study of curative FLASH-RT versus CONV-RT in patients with T1-T2 ... will be randomly allocated to low energy electron FLASH-RT (dose rate: 220–270 Gy/s) or to ...
Tópico(s): Radiation Therapy and Dosimetry
2024 - Elsevier BV | Clinical and Translational Radiation Oncology
Jean Bourhis, Wendy Jeanneret Sozzi, Patrik Gonçalves Jorge, Olivier Gaide, Claude Bailat, F. Duclos, David Patin, Mahmut Özşahin, François Bochud, Jean‐François Germond, Raphaël Moeckli, Marie‐Catherine Vozenin,
... to conventional radiotherapy (RT) in pre-clinical studies, FLASH-RT was shown to reproducibly spare normal tissues, while ... here the treatment of a first patient with FLASH-RT. Material & methods A 75-year-old patient presented ... was generally poor, and it was hypothesized that FLASH-RT could offer an equivalent tumor control probability, while ... a 5.6-MeV linac specifically designed for FLASH-RT. The prescribed dose to the PTV was 15 ... promising and prompt to further clinical evaluation of FLASH-RT. Conclusion This first FLASH-RT treatment was feasible ...
Tópico(s): Virus-based gene therapy research
2019 - Elsevier BV | Radiotherapy and Oncology
Ibrahim Oraiqat, Wei Zhang, Dale W. Litzenberg, Kwok L. Lam, Noora Ba Sunbul, Jean M. Moran, Kyle C. Cuneo, Paul L. Carson, Xueding Wang, Issam El Naqa,
Purpose FLASH radiotherapy (FLASH‐RT) is a novel irradiation modality with ultra‐high dose rates (>40 Gy/s) that have shown tremendous promise for ... its extremely high dose rates, clinical translation of FLASH‐RT is hampered by risky delivery and current limitations ... for real‐time deep tissue dose measurements during FLASH‐RT. The underlying hypothesis is that iRAI can enable ... used to study the feasibility of iRAI for FLASH‐RT using 6 MeV electrons from a modified Varian ... iRAI for real‐time deep tissue dosimetry in FLASH‐RT. Our results show that iRAI signals are linear ...
Tópico(s): Nuclear Physics and Applications
2020 - Wiley | Medical Physics
Issam El Naqa, Brian W. Pogue, Rongxiao Zhang, Ibrahim Oraiqat, Katia Parodi,
Abstract FLASH radiotherapy (FLASH‐RT) is an emerging ultra‐high dose (>40 Gy/s) delivery that promises to improve the therapeutic potential by limiting ... harnessed to meet the special emerging needs of FLASH‐RT and its associated high risks in planning and ... and possible solutions in the entire chain of FLASH‐RT treatment, from the planning, through the setup and ... or transient hypoxia on the relevant timescales of FLASH‐RT delivery. Perhaps most importantly at this time, these ... improve the understanding of the biological mechanisms of FLASH‐RT response in tumor and normal tissues. The high ...
Tópico(s): Medical Imaging Techniques and Applications
2022 - Wiley | Medical Physics
Marie‐Catherine Vozenin, Pauline De Fornel, Kristoffer Petersson, Vincent Favaudon, Maud Jaccard, Jean-François Germond, Benoît Petit, Marco Bürki, Gisèle Ferrand, David Patin, Hanan Bouchaab, Mahmut Özşahin, François Bochud, Claude Bailat, Patrick Devauchelle, Jean Bourhis,
... irradiation delivered at an ultrahigh dose rate called “FLASH-RT” and irradiation delivered at a conventional dose rate ... and progression-free survival (PFS) of single-dose FLASH-RT. Results: Using, respectively, depilation and fibronecrosis as acute and late endpoints, a protective effect of FLASH-RT was observed (≥20% dose-equivalent difference vs. Conv- ... Conclusions: Our results confirmed the potential advantage of FLASH-RT and provide a strong rationale for further evaluating FLASH-RT in human patients. See related commentary by Harrington, ...
Tópico(s): Ultrasound and Hyperthermia Applications
2018 - American Association for Cancer Research | Clinical Cancer Research
James C. L. Chow, Harry E. Ruda,
The advent of FLASH radiotherapy (FLASH-RT) has brought forth a paradigm shift in cancer treatment, showcasing remarkable normal cell sparing effects with ultra-high dose rates (>40 ... and the modulation of the tumor microenvironment through FLASH-RT. Examining these mechanisms, we explore the implications and challenges of integrating FLASH-RT into cancer treatment. The potential to spare normal ... offers new therapeutic strategies. Despite progress in understanding FLASH-RT, this review highlights knowledge gaps, emphasizing the need ...
Tópico(s): Boron Compounds in Chemistry
2024 - Multidisciplinary Digital Publishing Institute | Cells
Betina Børresen, Maja L. Arendt, Elise Konradsson, Kristine Jensen, Sven Å J Bäck, Per Munck af Rosenschöld, Crister Ceberg, Kristoffer Petersson,
... toxicity, hence the normal tissue sparing effect of FLASH RT potentially makes it especially advantageous for treating oral ... of dogs with spontaneous oral tumors treated with FLASH RT. Methods Privately-owned dogs with macroscopic malignant tumors ... treated with a single fraction of ≥30Gy electron FLASH RT and subsequently followed for 12 months. A modified conventional linear accelerator was used to deliver the FLASH RT. Results Eleven dogs were enrolled in this prospective ... This study shows that single-fraction high dose FLASH RT was generally effective in this mixed group of ...
Tópico(s): Veterinary Oncology Research
2023 - Frontiers Media | Frontiers in Oncology
James C. L. Chow, Harry E. Ruda,
Flash radiotherapy (Flash-RT) is an innovative technique used in radiotherapy for cancer treatment because it delivers an extremely high dose of ... second. This ultra-fast delivery of radiation distinguishes Flash-RT from conventional radiotherapy, which typically involves the delivery ... conducted in cell and preclinical models suggested that Flash-RT may spare normal tissues from radiation-related side ... to the ultra-high dose rate. Nevertheless, while Flash-RT shows promising results in preclinical and early clinical ...
Tópico(s): Effects of Radiation Exposure
2023 - Multidisciplinary Digital Publishing Institute | Encyclopedia
Wei Zou, Rongxiao Zhang, Emil Schüler, Paige A. Taylor, Anthony Mascia, Eric S. Diffenderfer, Tianyu Zhao, Ahmet S. Ayan, M. L. SHARMA, Amy S. Yu, Weiguo Lu, Walter Bosch, Christina Tsien, Murat Sürücü, Julianne Pollard‐Larkin, Jan Schuemann, Eduardo G. Moros, Magdalena Bazalova‐Carter, David J. Gladstone, Heng Li, Charles B. Simone, Kristoffer Petersson, Stephen F. Kry, Amit Maity, Billy W. Loo, Lei Dong, Peter G. Maxim, Ying Xiao, Jeffrey C. Buchsbaum,
FLASH radiation therapy (FLASH-RT), delivered with ultrahigh dose rate (UHDR), may allow patients to be treated with less normal tissue toxicity for a ... serve as reference points as we move toward FLASH-RT clinical trial performance. Some major questions regarding FLASH-RT are discussed, and next steps in this field are proposed. FLASH-RT has potential but is associated with significant risks ... access to treatment data will be critical as FLASH-RT moves into the clinical trials.
Tópico(s): Radiation Detection and Scintillator Technologies
2023 - Elsevier BV | International Journal of Radiation Oncology*Biology*Physics
Paul G. Barghouth, Stavros Melemenidis, Pierre Montay‐Gruel, Jonathan Ollivier, Vignesh Viswanathan, Patrik Gonçalves Jorge, Luis Soto, Brianna Lau, Cheyenne Sadeghi, Anushka Edlabadkar, Richard Zhang, Ning Ru, Janet E. Baulch, Rakesh Manjappa, Jinghui Wang, Marie Le Bouteiller, Murat Sürücü, Amy S. Yu, Karl Bush, Lawrie Skinner, Peter G. Maxim, Billy W. Loo, Charles L. Limoli, Marie‐Catherine Vozenin, Richard L. Frock,
... Here, we tested the hypothesis as to whether FLASH-RT generates decreased chromosomal translocations compared to CONV-RT. ... U87 glioblastoma lines were also performed to discern FLASH-RT vs CONV-RT DSB effects.Normoxic and physioxic ... repair but were indistinguishable between CONV-RT and FLASH-RT. Although no apparent increase in chromosome translocations was ... affect 293T clonogenic survival.Irrespective of oxygen tension, FLASH-RT produces translocations and junction structures at levels and ...
Tópico(s): Carcinogens and Genotoxicity Assessment
2023 - Elsevier BV | Radiotherapy and Oncology
Binwei Lin, Feng Gao, Yiwei Yang, Dai Wu, Yu Zhang, Gang Feng, Tangzhi Dai, Xiaobo Du,
... outcomes of animal experiments show that FLASH radiotherapy (FLASH-RT) can reduce radiation-induced damage in healthy tissue ... conventional dose-rate radiotherapy is another advantage of FLASH-RT. The first human patient received FLASH-RT in Switzerland in 2018. FLASH-RT may become one of the main radiotherapy technologies ... We summarize the history of the development of FLASH-RT, its mechanisms, its influence on radiotherapy, and its ...
Tópico(s): Radiation Detection and Scintillator Technologies
2021 - Frontiers Media | Frontiers in Oncology
Raphaël Moeckli, Patrik Gonçalves Jorge, Veljko Grilj, Roxane Oesterle, Nicolas Cherbuin, Jean Bourhis, Marie‐Catherine Vozenin, Jean‐François Germond, François Bochud, Claude Bailat,
... to validate it for preclinical animal FLASH radiotherapy (FLASH RT) experiments and for FLASH RT clinical human protocols. Methods The Mobetron ® device was ... characteristics tested. Conclusions The device is commissioned for FLASH RT preclinical biological experiments as well as FLASH RT clinical human protocols.
Tópico(s): Radiation Effects in Electronics
2021 - Wiley | Medical Physics
Eline Hageman, Pei-Pei Che, Max Dahele, Ben J. Slotman, Peter Sminia,
... dose-shaping technology have helped to achieve this. FLASH RT is a promising, novel treatment technique that seeks ... in tumor cells. The underlying biological mechanisms of FLASH RT, however, remain unclear. Three main mechanisms have been hypothesized to account for this differential FLASH RT effect between the tumor and healthy tissue: the ... unknown. Therefore, while there is great interest in FLASH RT as a means of targeting tumors with the ... tumors as standard photon RT is currently lacking. FLASH RT needs further preclinical investigation and well-designed in- ...
Tópico(s): Effects of Radiation Exposure
2022 - Multidisciplinary Digital Publishing Institute | Biomolecules
Pascal Froidevaux, Veljko Grilj, Claude Bailat, Walter Reiner Geyer, François Bochud, Marie‐Catherine Vozenin,
FLASH radiotherapy (FLASH-RT) enables the delivery of ultra-high dose rate (UHDR) radiation to a tumor, increasing the mean dose rate ... s−1and above. Animal models have demonstrated that FLASH-RT preserves healthy tissues while yielding similar tumor growth delay as conventional irradiation. Despite the promise of FLASH-RT, the physico-chemical and biological mechanisms underlying the ... oxygenation levels able to alter downstream responses to FLASH-RT. In this respect, lipid peroxidation is a chemical ...
Tópico(s): Mitochondrial Function and Pathology
2022 - Elsevier BV | Radiation Physics and Chemistry
Natalia Matuszak, Wiktoria Maria Suchorska, Piotr Milecki, Marta Kruszyna‐Mochalska, Agnieszka Misiarz, Jacek Pracz, Julian Malicki,
... ultra-high dose rate radiation to the target. FLASH-RT has been shown to reduce radiation-induced toxicity ... present article, we review the published data on FLASH-RT and discuss the current state of knowledge of ... also highlight the technological constraints and complexity of FLASH-RT and describe the physics underlying this modality, particularly ... on FLASH electrons and that clinical application of FLASH-RT is very limited. The incorporation of FLASH-RT into routine clinical radiotherapy will require the development ...
Tópico(s): Radiation Detection and Scintillator Technologies
2022 - Elsevier BV | Reports of Practical Oncology & Radiotherapy
Jean Bourhis, Pierre Montay‐Gruel, Patrik Gonçalves Jorge, Claude Bailat, Benoît Petit, Jonathan Ollivier, Wendy Jeanneret‐Sozzi, Mahmut Özşahin, François Bochud, Raphaël Moeckli, Jean‐François Germond, Marie‐Catherine Vozenin,
... dose-limiting normal tissue complications. In this context, FLASH-RT is emerging in the field. Consisting of delivering doses within an extremely short irradiation time, FLASH-RT has been identified as a promising new tool ... shown that compared to conventional dose-rate RT, FLASH-RT could control tumors while minimizing normal tissue toxicity. ... the main data supporting the clinical translation of FLASH-RT and explore its feasibility, the key irradiation parameters ...
Tópico(s): Effects of Radiation Exposure
2019 - Elsevier BV | Radiotherapy and Oncology
Rui Tang, Jianqiong Yin, Yuanxin Liu, Jianxin Xue,
... targeting tumor cells. In recent years, FLASH-Radiotherapy (FLASH-RT) has emerged as a cutting-edge research focus ... the treatment target in an ultra-short time, FLASH-RT produces the FLASH effect, which reduces the toxicity ... a brief overview of the development history of FLASH-RT and its impact on tumor control. Additionally, it ... this review discusses the challenges faced in translating FLASH-RT into clinical practice and outlines its promising future ...
Tópico(s): Advanced Radiotherapy Techniques
2024 - Elsevier BV | Cancer Letters
Meng Suo, Hanchen Shen, Meng Lyu, Yi Jiang, Xiaoming Liao, Wei Tang, Pan You, Tianfu Zhang, Shipeng Ning, Ben Zhong Tang,
Abstract Compared to conventional radiotherapy (RT), FLASH‐RT delivers ultra‐high dose radiation, significantly reducing damage to normal tissue while guaranteeing the effect of cancer treatment. However, cancer recurrence and ... CSCs for inhibiting cancer recurrence and metastasis after FLASH‐RT therapy . Aspirin released in TAFL system triggered by ... treatment significantly inhibited tumor recurrence and metastasis after FLASH‐RT therapy. In summary, this TAFL system provides a new idea for the future clinical application of FLASH‐RT therapy.
Tópico(s): RNA Interference and Gene Delivery
2024 - Wiley | Small
Yasaman Alaghband, Barrett D. Allen, Enikö A. Kramár, Richard Zhang, Olivia G.G. Drayson, Ning Ru, Benoît Petit, Aymeric Almeida, Ngoc-Lien Doan, Marcelo A. Wood, Janet E. Baulch, Paola Ballesteros‐Zebadúa, Marie‐Catherine Vozenin, Charles L. Limoli,
Implementation of ultra-high dose-rate FLASH radiotherapy (FLASH-RT) is rapidly gaining traction as a unique cancer ... each instance, extensive and rigorous behavioral testing showed FLASH-RT to preserve cognitive indices of learning and memory ... mechanistic blueprint from synapse to cognition detailing how FLASH-RT reduces normal tissue complications in the irradiated brain. ... Functional preservation of cognition and LTP after hypofractionated FLASH-RT are linked to a protection of synaptic integrity ...
Tópico(s): Radiation Therapy and Dosimetry
2023 - American Association for Cancer Research | Cancer Research Communications