Tony Rushton, Patrick Soper, Phil Yates, Jon Ashworth, Cath Urquhart, Raymond Snoddy Media Editor, Ian Bennett, David Adams, Stella Shamoon, Robert Cole, Portia Colwell, Andrew Pierce, Douglas Emmott, Sally Brock, James Moore, Grace Bradberry, Johnny Dee, A. S., Jane MacQuitty, Gary Neville, John Morgan, Jill Hartley, Lesley Russell, Julian Lee, Bernard Kaukas, Mark Souster, Richard Hobson, Gershon Ellenbogen, Paul Sanders, Ivo Tennant, Robert Lea, Michael Evans Defence Editor, Douglas Friedli, James Bone, Stephanie Theobald, Clive Davis, John Draper, Claire Brereton, Elizabeth Judge, Ian Cundell, M. T., Richard Eaton, Sharon Linnard, Dominic Bradbury, K. J. Barker, Christine Buckley, James Doran, Allan Hall and Roland Watson, Tony Patrick, Clare Stewart, Jane Wilson, John Thicknesse, Antonia Senior, Carl Evans, Conal Urquhart, Pat Gibson, D. J. M. Turner, Norman Davies, John Clarke, D. R., D. G. Duke, Thrasy Petropoulos, Melanie Tringham, Stewart Tendler Crime Correspondent, David Charter Education Correspondent, Geoffrey Owen, Dominic Walsh, Steve Bird, Ruth Gledhill, Stephen Anderton's, Tim Reid, Ruth Gledhill Religion Correspondent, Dalya Alberge Arts Correspondent, David Hunter, Peter Hughes, Jo Morris, Stephen Farrell, Oliver Wright, Mark Inglefield, John Hancock, Peter Millar, T. P., Roland Watson Political Watson, Alice Lagnado, Frances Bissell, David Hands, P. B., Charles Bremner, Helen Rumbelow, Kevin McCarra and Stephen Wood, Conal Urquhart and Richard Ford, Peter Barnard, Anthea Lawson, Michael Gardner, Patience Wheatcroft Business Editor, Derwent May, James Urquhart, James Doran City Correspondent, Mary Loudon, Jasper Gerard, Russell Kempson, Paula Hawkins, Anna Moore, Daniel McGrory, Paul Armstrong, Ed Potton, Justin Langer, Stephen Anderton, M. Hammerton, Lea Paterson and Philip Webster, David Lister, Steve Deeks, Michael Theodoulou, Christopher Martin-Jenkins, James Aufenast, Toni Carragher, Stephen Farrell South Asia Correspondent, Rob Wright, Geoffrey Dean, Christina Koning, Stephen Wood, Adam Jones, J. H. Baker, Raymond Keene, Vaughan Freeman, David Robinson, Clive Mathieson, Matt Dickinson, Lucy Pinney, Anne Boston, James Allcock, Christine Buckley Industrial Editor, Graham Doswell, Managing Director, Jeannette Hyde, Clive Petty, Walter Cairns, Chris Ayres Media Business Correspondent, Adam Jones and James Doran, Oliver Holt, Caroline Donald, Damian Whitworth, Christopher Martin-Jenkins Chief Cricket Correspondent, Chris Porteous, John Stern, Nick Hasell, Dalya Alberge, Robin Renwick, David Hands Rugby Correspondent, Martin Fletcher European Correspondent, Anne Ashworth, Elizabeth James, Jane Shilling, Mel Webb, Srikumar Sen Boxing Correspondent, Kevin McCarra, Amanda Craig, Chris McGrath, Clare Catford, Tim Wapshott, William McConnell, Russell Jenkins, Michael Austin, Clarissa Hyman, Lionel Leventhal, Jane Owen, Ben MacIntyre, Helen Pridham, Michael Dobbs, John Goodbody Sports News Correspondent, Chlöe Bryan-Brown, Richard Beeston Diplomatic Editor, Brenda Jenkinson, Richard Miles, John Naish, Graham Searjeant, Annabelle Thorpe, Nick Roe, Geoffrey Rowell, Martin Waller, Minty Clinch, Chris Ayres, Peter Ingham, Nigel Hawkes Science Editor, Danny Baker, Fran Littlewood, Philip Johnston, Stuart Birch, Jill Crawshaw, Richard Morrison, Alyson Rudd, Tom Chesshyre, Elizabeth Buchan, Valerie Grove, Adam Sherwin, Hugh Weatherly, Allan Hall, Robert Whymant, Kirsty Young, Daisy Hope-Johnston, Jan Godfrey, Lea Paterson Economics Correspondent, Roland Watson Chief Political Correspondent, Sally Patten, Nick Baty, Spencer Bright, Cath Urquhart Travel Editor, Fraser Nelson Retail Correspondent, Maurice Fitzpatrick, Patience Wheatcroft, Christopher Irvine, William Gray, William Feaver, Susan Emmett, Arthur Leathley Transport Correspondent,
... 224 06065 1 Paperbacks The Tulip Anna Pavord Scar culture Contributors Travelling in time and space Catfish & ... To Mars (PG), 2.15pm ,… 11.35pm on (Fn/Sat), Snow Day (PG), 10.55am… Bournemouth Odeon ...
2000 - Gale Group | TDA
Jonathan P. Andrews, Jaana Marttala, Edward J. Macarak, Joel Rosenbloom, Jouni Uitto,
... Hendrix, 1983Kischer C.W. Hendrix M.J. Fibronectin (FN) in hypertrophic scars and keloids.Cell Tissue Res. 1983; 231: 29- ... Hendrix, 1983Kischer C.W. Hendrix M.J. Fibronectin (FN) in hypertrophic scars and keloids.Cell Tissue Res. 1983; 231: 29-37PubMed Google Scholar; Sible et al., 1994Sible J.C. Eriksson E. Smith S.P. et al.Fibronectin gene expression differs in normal and abnormal human wound healing.Wound Repair Regen. 1994; 2: 3-19Crossref PubMed Scopus (18) Google Scholar), the high level of FN-EDA expression in keloid tissue has not been ...
Tópico(s): Wound Healing and Treatments
2015 - Elsevier BV | Journal of Investigative Dermatology
Greg Szulgit, Ross Rudolph, Amy Wandel, Mayer Tenenhaus, Reed Panos, Humphrey Gardner,
... Hendrix, 1983Kischer C.W. Hendrix M.J. Fibronectin (FN) in hypertrophic scars and keloids.Cell Tissue Res. 1983; 231: 29- ... Hendrix, 1983Kischer C.W. Hendrix M.J. Fibronectin (FN) in hypertrophic scars and keloids.Cell Tissue Res. 1983; 231: 29- ...
Tópico(s): Cell Adhesion Molecules Research
2002 - Elsevier BV | Journal of Investigative Dermatology
Ludger J.M. Meyer, Barbara M. Egbert, Svetlana Shuster, Robert Stern, Shirley B. Russell, James Russell, Joel S. Trupin,
... Hendrix, 1983Kischer C.W. Hendrix M.J. Fibronectin (FN) in hypertrophic scars and keloids.Cell Tissue Res. 1983; 231: 29- ...
Tópico(s): Dermatologic Treatments and Research
2000 - Elsevier BV | Journal of Investigative Dermatology
C. Ward Kischer, MaryJ.C. Hendrix,
Tópico(s): Cellular Mechanics and Interactions
1983 - Springer Science+Business Media | Cell and Tissue Research
Ting He, Xiaozhi Bai, Longlong Yang, Lei Fan, Yan Li, Linlin Su, Jianxin Gao, Shichao Han, Dahai Hu,
... Immunohistochemistry was used to detect expression of Col1, FN and TGF-β1 in skin and scar tissue. Fibroblasts were stimulated with TGF-β1 to ... and JNK in the LB-mediated inhibition of scar formation. Results: FN and Col1 were up regulated in hypertrophic scars. LB down regulated p-ERK and p-JNK ... JNK down regulated the expression of Col1 and FN in TGF-β1-stimulated fibroblasts. LB down regulated protein levels of p-ERK and p-JNK in cultured hypertrophic scar tissue ex vivo. Conclusions: This study suggests that ...
Tópico(s): Wound Healing and Treatments
2015 - Karger Publishers | Cellular Physiology and Biochemistry
William J. Sahl, Henry Clever,
... Google Scholar 117 Kischer CW, Hendrix MJ. Fibronectin (FN) in hyper trophic scars and keloids. Cell Tissue Res 1983; 231: 29– ...
Tópico(s): Cutaneous lymphoproliferative disorders research
1994 - Wiley | International Journal of Dermatology
Qun Xie, Dandan Liu, Mosheng Yu, Xiaowei Wu, Yueqiang Zhao, Qiang Hu, Qi Wang,
... and p38. It was demonstrated that HOXB9, laminin, FN and Col1 were upregulated in hypertrophic scar tissues, and HOXB9 upregulated laminin, FN, Col1, p‑ERK, p‑JNK and p38, potentially by interacting directly with p38. Furthermore, FBs overexpressing HOXB9 exhibited enhanced contractile capacity. In conclusion, the present study demonstrated that HOXB9 may facilitate hypertrophic scar formation via activating the mitogen‑activated protein kinase ...
Tópico(s): Skin Protection and Aging
2017 - Spandidos Publishing | Molecular Medicine Reports
• The histologic localization of fibronectin (FN) in normal human skin, granulation tissue, hypertrophic scar, mature scar, progressive systemic sclerotic skin, and tissue of other fibrotic disorders was investigated by an indirect immunofluorescence technique using specific ... curling arrangement throughout the dermis. On the contrary, FN gradually decreased in the wound of the mature scar five to 20 years after wounding. There were some interesting observations among other diseases. In the skin of patients with progressive systemic sclerosis and morphea, FN was found to be localized faintly on the ...
Tópico(s): Skin and Cellular Biology Research
1985 - American Medical Association | Archives of Dermatology
The histologic localization of fibronectin (FN) in normal human skin, granulation tissue, hypertrophic scar, mature scar, progressive systemic sclerotic skin, and tissue of other fibrotic disorders was investigated by an indirect immunofluorescence technique using specific ... curling arrangement throughout the dermis. On the contrary, FN gradually decreased in the wound of the mature scar five to 20 years after wounding. There were some interesting observations among other diseases. In the skin of patients with progressive systemic sclerosis and morphea, FN was found to be localized faintly on the ...
Tópico(s): Dermatologic Treatments and Research
1985 - American Medical Association | Archives of Dermatology
C. Ward Kischer, Herbert N. Wagner, Jana Pindur, Hana Holubec, Mark Jones, Judith B. Ulreich, Philip Scuderi,
... lines were evaluated by the ELISA method for FN and a micro Lowry assay for PR. The scar lines showed statistically significant increases in the amount ... a fibroblast-type cell line from a hypertrophic scar or keloid produces more FN/PR over time than the normal fibroblast-type ...
Tópico(s): Collagen: Extraction and Characterization
1989 - Taylor & Francis | Connective Tissue Research
... highly sensitive enzyme-linked immunosorbent assay for fibronectin (FN) production by fibroblasts from scar tissue. The amount of FN produced by fibroblasts from scar tissue adjacent to an area of squamous cell ...
Tópico(s): Cancer Cells and Metastasis
1987 - Oxford University Press | British Journal of Dermatology
Tópico(s): Periodontal Regeneration and Treatments
1990 - Springer Science+Business Media | Cytotechnology
Hadeel A. Al‐Rawaf, Sami A. Gabr, Ahmad H. Alghadir,
... as measured by higher expression levels of HPX, FN, collagen, accelerated wound closure, complete epithelialization, and scar formation in short periods (11-13 days, (P < ... D and gingerol activate vascularization, fibrin deposition (HPX, FN, and collagen), and myofibroblasts in such manner to synthesize new tissues and help in the scar formation. Accordingly, three miRNAs, miR-155, miR-146a, ...
Tópico(s): Diabetic Foot Ulcer Assessment and Management
2019 - Hindawi Publishing Corporation | Evidence-based Complementary and Alternative Medicine
Marcel Niemann, Tazio Maleitzke, Markus Jahn, Katharina Salmoukas, Karl F. Braun, Frank Graef, Ulrich Stöckle, Sebastian Meller,
... and CCD angle differences were maintained over time. FNS patients had shorter scars and reported fewer emotional problems and more energy. There were no differences between groups regarding the remaining SF-36 sub-scores, Harris Hip Score, and NRS.The FNS allows for a comparable leg length, femoral offset, ...
Tópico(s): Bone and Joint Diseases
2023 - Multidisciplinary Digital Publishing Institute | Life
Byung‐Jae Kang, Hwan Kim, Seul Ki Lee, Joohyun Kim, Yiming Shen, Sun-Young Jung, Kyung‐Sun Kang, Sung Gap Im, So Yeong Lee, Mincheol Choi, Nathaniel S. Hwang, Je‐Yoel Cho,
... MI size and fibrosis, and an increase in scar thickness. This study indicates that FN-immobilized biofunctional PCL nanofibers could be an effective ...
Tópico(s): Cardiac Structural Anomalies and Repair
2014 - Elsevier BV | Acta Biomaterialia
... record of biocompatibility. The early experience with Radiance FN suggests this agent to be both safe and effective in softening facial folds, filling depressed scars, and adding soft tissue volume. Although Radiance FN has been touted as a "longer-lasting" injectable, ...
Tópico(s): Dermatologic Treatments and Research
2004 - Thieme Medical Publishers (Germany) | Facial Plastic Surgery
... intraductal papillomas. Intraductal carcinomas, multiple papillomas and radial scars could display a substantial staining for FN, sometimes enclosing small islands or tubules of epithelial ...
Tópico(s): HER2/EGFR in Cancer Research
1990 - Wiley | Apmis
Jianfeng Zheng, Jun Luo, Jiliang Mo, Jun Peng, Xuesong Jin, Minhao Zhu,
... imposed normal loads and displacement amplitudes. The Ft/Fn curves exhibited different variation trends in different fretting running regimes. The fretting scars presented slight damage in partial slip regime. In ...
Tópico(s): Adhesion, Friction, and Surface Interactions
2009 - Elsevier BV | Tribology International
Huimin Shi, Huiying Wang, Shuhao Fu, Kang Xu, Xiaoyan Zhang, Yiqin Xiao, Wen Ye,
... migration of HTFs. Expressions of α-SMA and FN in these cells were also decreased by losartan pretreatment. Conclusions: Losartan attenuates scar formation of filtering bleb after trabeculectomy likely via ...
Tópico(s): Retinal Diseases and Treatments
2017 - Cadmus Press | Investigative Ophthalmology & Visual Science
Yin‐Kai Chao, Chi‐Ju Yeh, Mu-Hsien Lee, Yu‐Wen Wen, Hsien‐Kun Chang, Chen‐Kan Tseng, Yun‐Hen Liu,
... endoscopic findings as the only independent predictor of FN biopsy results. The negative predictive values were 77.8%, 61.9%, 52.6%, 30.3%, 23.1%, and 20.0% for the normal, scar, other findings, ulcer, stricture, and tumor categories, respectively (P < 0.001). In ESCC patients, the FN rate of endoscopic biopsy after nCRT is associated ...
Tópico(s): Gastric Cancer Management and Outcomes
2015 - Wolters Kluwer | Medicine
... and 85 years underwent subdermal injection with Radiance FN. The primary areas treated were lips, nasolabial folds, glabellar rhytids, marionette lines, prejowl depressions, acne scars, and surgical soft tissue defects. Patients were surveyed ...
Tópico(s): Dermatologic Treatments and Research
2004 - American Medical Association | Archives of Facial Plastic Surgery
Fang Xie, Li Teng, Jianjian Lu, Jiajie Xu, Chao Zhang, Liya Yang, Xiaoyang Ma, Minghao Zhao,
... synthesis (the expression of collagen I, collagen III, FN, and α-SMA protein) than ADMSC. In vivo, we found that IL-10-ADMSC speeded up wound healing time and reduced scar area and scar outstanding height. Same as in ...
Tópico(s): Periodontal Regeneration and Treatments
2022 - Hindawi Publishing Corporation | Mediators of Inflammation
Xinyi Wu, Yongmei Yang, Hui Guo, Yuan Chang,
... involved in the regulation of TGF-β1 autosecretion. FN is the main component of cell matrix and stroma, while type I collagen is the main component of stroma and scar tissue, so both expressions demonstrate the activation of corneal stroma and fibroblasts. Smad 4 blocks expression of TGF-β1 in stroma, with no effect on expression of CTGF, FN and type I collagen. Moreover, the upregulation of ... disappears in stroma, while the expressions of CTGF, FN and type I collagen last up to the 21st day. These data support our hypothesis that TGF-β1 plays an important role in activation of stromal cells in early phase of wound and the production of collagen by activated fibroblasts is mainly accomplished by CTGF. The expression of CTGF after wound directly affects production of connective tissue and the following scar formation. We also found that on the third ...
Tópico(s): Connective Tissue Growth Factor Research
2006 - Lippincott Williams & Wilkins | Chinese Medical Journal
Anna Ratajska, Scott E. Campbell,
... day 4; and (c) marking internalized capillaries. Both FNs were codistributed throughout the myocardium of each ventricle; however, cFN was less pronounced and not seen in mature scars. Ultrastructural examination revealed different kinds of intramyocytic inclusions, characterized by vacuoles containing fibrillar/flocculent material, remnants of unknown origin, or internalized capillaries. We conclude that FNs are markers of cardiac myocyte necrosis and early ...
Tópico(s): Protease and Inhibitor Mechanisms
1995 - Elsevier BV | Cardiovascular Pathology
Magnús K. Magnússon, Deane F. Mosher,
... the wound healing process. The formation of the scar and the remodeling of the myocardial wall are major determinants of patient outcome. As expected, FN is rapidly expressed after myocardial infarction in both ...
Tópico(s): Cellular Mechanics and Interactions
1998 - Lippincott Williams & Wilkins | Arteriosclerosis Thrombosis and Vascular Biology
X. Wang, Jun Chu, Chenlei Wen, Shibo Fu, Youcun Qian, Yan Wo, Chenyu Wang, D.R. Wang,
... and protein expression, and higher levels of fibronectin (FN) compared to control groups. In addition, knockdown of TLP promoted the phosphorylation of Smad3 but repressed Smad2 and Erk-1/2 phosphorylation in human hypertrophic scar fibroblasts compared to control groups. The reduction of ...
Tópico(s): Tendon Structure and Treatment
2015 - Elsevier BV | Experimental Cell Research
Fanwei Meng, Vladimir Hlady, Patrick A. Tresco,
... of an astrocyte tissue construct, demonstrating how natural scar tissue may develop in situ into potent barriers. In such constructs the spatial organization of astrocyte derived FN maintained its organizational anisotropy throughout the thickness of ...
Tópico(s): Neuroscience and Neural Engineering
2011 - Elsevier BV | Biomaterials
Raghave Upadhyaya, Samuel H. Cole, Michael Klebuc, Amy S. Xue,
... laceration repair, of which there were no missed FN injuries nor scar revision procedures. Of 199 surgically managed facial injuries, 15 patients underwent FN exploration with 8/15 positive for FN injury. ...
Tópico(s): Facial Nerve Paralysis Treatment and Research
2023 - Wolters Kluwer | Plastic & Reconstructive Surgery Global Open
Hadeel A. Al‐Rawaf, Sami A. Gabr, Ahmad H. Alghadir,
... contained more collagen expressed as measures of HPX, FN, and NO and more angiogenesis, compared to wounds treated with standard control vehicle. Diabetic and nondiabetic wounds treated with green tea (0.6%) for three weeks had lesser scar width and greater re-epithelialization in shorter periods ...
Tópico(s): Diabetic Foot Ulcer Assessment and Management
2019 - Hindawi Publishing Corporation | Evidence-based Complementary and Alternative Medicine