Produção Nacional
Revisado por pares
Cora N. Sternberg, Karim Fizazi, Fred Saad, Neal D. Shore, Ugo De Giorgi, David F. Penson, Ubirajara Ferreira, Petro Ivashchenko, Eleni Efstathiou, Katarzyna Madziarska, Michael Kolinsky, Daniel Iracema Cubero, Bettina Noerby, Fabian Zohren, Xun Lin, Katharina Modelska, Jennifer Sugg, Joyce Steinberg, Maha Hussain,
5515 Background: PROSPER previously demonstrated a statistically significant and clinically meaningful improvement in metastasis-free survival (MFS) (hazard ratio [HR] 0.29; 95% CI 0.24-0.35; P < .001) in men with nmCRPC and rapidly rising prostate-specific antigen (PSA) who received ENZA. When first reported, OS was immature with only 165 of 596 (28%) prespecified deaths. Here we report results from the final OS analysis. Methods: Men with nmCRPC, PSA doubling time ≤ 10 mo, and PSA ≥ 2 ng/mL at screening continued ...
Tópico(s): Radiopharmaceutical Chemistry and Applications
2020 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Produção Nacional
Revisado por pares
Cora N. Sternberg, Karim Fizazi, Fred Saad, Neal D. Shore, Ugo De Giorgi, David F. Penson, Ubirajara Ferreira, Eleni Efstathiou, Katarzyna Madziarska, Michael Kolinsky, Daniel de Iracema Gomes Cubero, Bettina Noerby, Fabian Zohren, Xun Lin, Katharina Modelska, Jennifer Sugg, Joyce Steinberg, Maha Hussain,
Preliminary trial results showed that enzalutamide significantly improved metastasis-free survival among men who had nonmetastatic, castration-resistant prostate cancer and rapidly increasing prostate-specific antigen (PSA) levels while taking androgen-deprivation therapy. Results from the final analysis of overall survival have not yet been reported. In this double-blind, phase 3 trial, men with nonmetastatic, castration-resistant prostate cancer (defined on the basis of conventional imaging and ...
Tópico(s): Prostate Cancer Diagnosis and Treatment
2020 - Massachusetts Medical Society | New England Journal of Medicine
María Jesús Álvarez-Cubero, Luis Javier Martínez-González, Inmaculada Robles‐Fernandez, José Fabián Martínez‐Herrera, G. Garcia-Rodriguez, Manrique Pascual-Geler, J.M. Cózar, José A. Lorente,
Tópico(s): Genetic factors in colorectal cancer
2016 - Adis, Springer Healthcare | Molecular Diagnosis & Therapy
Marius Maximilian Woitok, Miguel Eugenio Zoubek, Dennis Doleschel, Matthias Bartneck, Mohamed Ramadan Mohamed, Fabian Kießling, Wiltrud Lederle, Christian Trautwein, Francisco Javier Cubero,
Abstract Lipid-based RNA nanocarriers have been recently accepted as a novel therapeutic option in humans, thus increasing the therapeutic options for patients. Tailored nanomedicines will enable to treat chronic liver disease (CLD) and end-stage liver cancer, disorders with high mortality and few treatment options. Here, we investigated the curative potential of gene therapy of a key molecule in CLD, the c-Jun N-terminal kinase-2 ( Jnk2 ). Delivery to hepatocytes was achieved using a lipid-based clinically ...
Tópico(s): MicroRNA in disease regulation
2020 - Springer Nature | Cell Death and Disease
Francisco Javier Cubero, Gang Zhao, Yulia A. Nevzorova, Maximilian Hatting, M. Al Masaoudi, Julien Verdier, Peng Jin, Frederik M. Schaefer, N. Hermanns, Mark V. Boekschoten, Christoph Grouls, Nikolaus Gaßler, Fabian Kießling, Michael Müller, Roger J. Davis, Christian Liedtke, Christian Trautwein,
Background & Aims Chronic liver injury triggers complications such as liver fibrosis and hepatocellular carcinoma (HCC), which are associated with alterations in distinct signalling pathways. Of particular interest is the interaction between mechanisms controlled by IKKγ/NEMO, the regulatory IKK subunit, and Jnk activation for directing cell death and survival. In the present study, we aimed to define the relevance of Jnk in hepatocyte-specific NEMO knockout mice (NEMOΔhepa), a genetic model of chronic ...
Tópico(s): Immune Response and Inflammation
2014 - Elsevier BV | Journal of Hepatology
Emily G. Simmonds, Kwaku Peprah Adjei, Christoffer Wold Andersen, Janne Cathrin Hetle Aspheim, Claudia Battistin, Nicola Bulso, Hannah M. Christensen, Benjamin Cretois, Ryan John Cubero, Iván A. Davidovich, Lisa Dickel, Benjamin Dunn, Etienne Dunn‐Sigouin, Karin Dyrstad, Sigurd Einum, Donata Giglio, Haakon Gjerløw, Amélie Godefroidt, Ricardo González‐Gil, Soledad Gonzalo Cogno, Fabian Große, Paul R. Halloran, Mari F. Jensen, John Kennedy, Peter Egge Langsæther, Jack H. Laverick, Debora Lederberger, Camille Li, Elizabeth G. Mandeville, Caitlin P. Mandeville, Espen Moe, Tobias Navarro Schröder, David Nunan, Jorge Sicacha-Parada, Melanie Rae Simpson, Emma Sofie Skarstein, Clemens Spensberger, Richard Stevens, Aneesh C. Subramanian, Lea Svendsen, Ole Magnus Theisen, Connor Watret, Robert B. O’Hara,
Quantifying uncertainty associated with our models is the only way we can express how much we know about any phenomenon. Incomplete consideration of model-based uncertainties can lead to overstated conclusions with real-world impacts in diverse spheres, including conservation, epidemiology, climate science, and policy. Despite these potentially damaging consequences, we still know little about how different fields quantify and report uncertainty. We introduce the "sources of uncertainty" framework, ...
Tópico(s): Climate change impacts on agriculture
2022 - Cell Press | iScience
David Genı́s, Sara Ortega‐Cubero, Héctor San Nicolás, Jordi Corral, Josep Gardenyes, Laura Jorge, Eva López, Berta Campos, Elena Lorenzo, Raúl Tonda, Sergi Beltrán, M. Negre Busó, María Obón, Brigitte Beltran, Laura Fàbregas, Berta Alemany, Fabian Márquez, Lluís Ramió‐Torrentà, Jordi Gich, Vı́ctor Volpini, Pau Pástor,
Objective To describe a new spinocerebellar ataxia (SCA48) characterized by early cerebellar cognitive-affective syndrome (CCAS) and late-onset SCA. Methods This is a descriptive study of a family that has been followed for more than a decade with periodic neurologic and neuropsychological examinations, MRI, brain SPECT perfusion, and genetic analysis. Whole exome sequencing was performed in 3 affected and 1 unaffected family member and subsequently validated by linkage analysis of chromosome 16p13.3. Results ...
Tópico(s): Neurological diseases and metabolism
2018 - Lippincott Williams & Wilkins | Neurology
Maximilian Hatting, FJ Cubero, Fabian Schumacher, Guofen Zhao, Gernot Sellge, N Gaßler, Christian Liedtke, Christian Trautwein,
Aims: Caspase 8, an initiator caspase, plays a crucial role in the induction of apoptosis. Increased apoptotic cell death is a prominent feature of non-alcoholic steatohepatitis (NASH) in humans and animal models. Therefore modulating Caspase 8 activity seems an attractive experimental approach in the treatment of NASH. However, it is essential to identify the mechanisms of Caspase 8 activation and their substrate requirements in order to develop effective inhibitors. Aim: To dissect the role of ...
Tópico(s): Hepatitis B Virus Studies
2012 - Thieme Medical Publishers (Germany) | Zeitschrift für Gastroenterologie
Francisco J. Lopez-Valpuesta, Jonathan W. Nyce, T. A. Griffin-Biggs, John Ice, R.D. Myers,
... M, Sparta D, Fee J, Knapp D and Cubero I (2003) Alcoholism and obesity: overlapping neuropeptide pathways?, ... S0083-6729(08)60921-8, (51-66), . Ashur-Fabian O, Giladi E, Brenneman D and Gozes I ( ...
Tópico(s): Hypothalamic control of reproductive hormones
1996 - Royal Society | Proceedings of the Royal Society B Biological Sciences
Jakub Fronczek, Kamil Polok, Dylan W. de Lange, Christian Jung, Michael Beil, Andrew Rhodes, Jesper Fjølner, Jacek Górka, Finn H. Andersen, Antonio Artigas, Maurizio Cecconi, Steffen Christensen, Michael Joannidis, Susannah Leaver, Brian Marsh, Alessandro Morandi, Rui P. Moreno, Sandra Oeyen, Christina Agvald‐Öhman, Bernardo Bollen Pinto, Joerg C. Schefold, Andreas Valentin, Sten Walther, Ximena Watson, Tilemachos Zafeiridis, Sigal Sviri, Peter Vernon van Heerden, Hans Flaatten, Bertrand Guidet, Wojciech Szczeklik, René Schmutz, Fabian Wimmer, Philipp Eller, Michael Joannidis, Pieter De Buysscher, Nikolaas De Neve, Sandra Oeyen, Walter Swinnen, Bernardo Bollen Pinto, Paul Abraham, Leila Hergafi, Joerg C. Schefold, Ewelina Biskup, Pinilla Roman Hervey Piza, I. Taliadoros, Jesper Fjølner, Nilanjan Dey, Christoffer Sølling, Bodil Steen Rasmussen, Steffen Christensen, Xavier Forceville, Guillaume Besch, Hervé Mentec, P. Michel, Philippe Mateu, P. Michel, Lucie Vettoretti, Jérémy Bourenne, Nathalie Marin, Max Guillot, Nadia Aïssaoui, Cyril Goulenok, Nathalie Thieulot-Rolin, Jonathan Messika, Lionel Lamhaut, Bertrand Guidet, Cyril Charron, Alexander Lauten, Anne Lena Sacher, Thorsten Brenner, Marcus Franz, Frank Bloos, Henning Ebelt, Stefan J. Schaller, Kristina Fuest, Christian Rabe, Thorben Dieck, Stephan Steiner, Tobias Graf, Amir M. Nia, Chul Won Jung, Rolf Alexander Jánosi, Patrick Meybohm, Philipp Simon, Stefan Utzolino, Tim Rahmel, Eberhard Barth, Chul Won Jung, Michael Schuster, Zoi Aidoni, Stavros Aloizos, P. Tasioudis, Klairi Lampiri, V. Zisopoulou, Ifigenia Ravani, E. Pagaki, Anna Antoniou, Θεόδωρος Κατσούλας, A. Kounougeri, Giorgos Marinakis, Fotios Tsimpoukas, Αikaterini Spyropoulou, Paris Zygoulis, Aikaterini Kyparissi, Mrigank S. Gupta, Mohan Gurjar, imatinibem mají, Ian Hayes, Brian Marsh, Yvelynne P. Kelly, Andrew Westbrook, G Fitzpatrick, M. Maheshwari, Catherine Motherway, Giampiero Negri, Savino Spadaro, Giuseppe Nattino, M. Pedeferri, Annalisa Boscolo, Silvia Rossi, Giuseppe Calicchio, L. Cubattoli, Gabriella Di Lascio, Mario Barbagallo, F. Berruto, Daniela Codazzi, Andrea Bottazzi, P Fumagalli, G. Negro, Gabriele Lupi, Francesco Savelli, G. A. Vulcano, Roberto Fumagalli, Andrea Marudi, Ugo Lefons, Rosalba Lembo, M. Babini, A. Paggioro, Vieri Parrini, M. Zaccaria, Stefano Clementi, C. Gigliuto, Francesca Facondini, S Pastorini, Sara Munaron, Italo Calamai, A. Bocchi, Andrea Adorni, Maria Grazia Bocci, Andrea Cortegiani, Tiziana Casalicchio, S. Mellea, Emauele Graziani, Massimo Barattini, Elisabetta Brizio, Marianna Rossi, Michael Hahn, Hans Flaatten, N. Kemmerer, Hans Frank Strietzel, Knut Dybwik, T. Legernaes, Pål Klepstad, Elinor Jeanette Olaussen, Keith M. Olsen, O. M. Brresen, G. Bjorsvik, Fahimeh Andersen, S. Maini, Lutz Fehrle, Mirosław Czuczwar, Paweł Krawczyk, Mirosław Ziętkiewicz, Łukasz R. Nowak, Katarzyna Kotfis, Katarzyna Cwyl, Ryszard Gajdosz, Jowita Biernawska, Romuald Bohatyrewicz, Ryszard Gawda, Paweł Grudzień, Paweł Nasiłowski, Natalia Popek, Waldemar Cyrankiewicz, Katarzyna Wawrzyniak, Marek Wnuk, Dariusz Maciejewski, Dorota Studzińska, Maciej Żukowski, Szymon Bernas, Mariusz Piechota, Wojciech Szczeklik, Ilona Nowak, Jakub Fronczek, Marta Serwa, Waldemar Machała, Jan Stefaniak, Maria Wujtewicz, Paul K. Maciejewski, Małgorzata Szymkowiak, Barbara Adamik, Kamil Polok, Jacek Górka, Nuno Catorze, Miguel Castelo-Branco, Nélson Barros, Iliene Carolina Barros, Andriy Krystopchuk, Teresa Honrado, Cardoso de Sousa, F. García Muñoz, M. Rebêlo, R. Gomes, José Pedro L. Nunes, Celeste Dias, Ângela Fernandes, Cristina Petrişor, Bendelic Constantin, Vladislav Belskiy, B. Boskholov, E. Rodríguez, Gerardo Aguilar, G. Masdeu, Marián Irazábal Jaimes, Adriana Mira, María Bodí, Jason A. Mendoza, Sonia López‐Cuenca, Mauricio Guzmán, Jesús Rico‐Feijoo, Mercedes Ibarz, Josep Trenado, Rafael Kawati, Joakim Sivik, Jessica Nauska, Daniel Smole, Fredric Parenmark, J. Lyrén, Klaus Juergen Rockstroh, Sara Rydén, Martin Spångfors, Morten Strinnholm, Sten Walther, Lina De Geer, P.-J. Nordlund, S. Pålsson, Harald Zetterquist, Annette Nilsson, Klara Thiringer, Mårten Jungner, Björn P. Bark, B. Nordling, Helena Sköld, Caroline Brorsson, Sofia Persson, Annika Bergström, Johan Berkius, Jessica Holmström, I. van Dijk, L. E. M. van Lelyveld-Haas, Tim C. Jansen, Fleur G. C. A. Nooteboom, Peter H. J. van der Voort, Dylan W. de Lange, Willem Dieperink, M. C. de Waard, Annemieke Smet, Laura Bormans, Tom Dormans, Ged Dempsey, Sunny Mathew, Ashok Raj, Irina Grecu, Jason Cupitt, Tom Lawton, Ross A. Clark, Mihai Popescu, Nick Spittle, Maria Faulkner, Amanda Cowton, Patricia Williams, E. Elloway, Michael Reay, Srikanth Chukkambotla, R. Kumar, Nawaf Al-Subaie, L. Kent, Tamm Ti, Istvan Kajtor, Kathleen Burns, Richard Pugh, Marlies Ostermann, Elisa Kam, H. Bowyer, Nina Smith, M. Templeton,
Abstract Background The Clinical Frailty Scale (CFS) is frequently used to measure frailty in critically ill adults. There is wide variation in the approach to analysing the relationship between the CFS score and mortality after admission to the ICU. This study aimed to evaluate the influence of modelling approach on the association between the CFS score and short-term mortality and quantify the prognostic value of frailty in this context. Methods We analysed data from two multicentre prospective ...
BioMed Central
Ramesh Nadarajah, Peter Ludman, Yolande Appelman, Salvatore Brugaletta, Andrzej Budaj, Héctor Bueno, Kurt Huber, Vijay Kunadian, Sergio Leonardi, Maddalena Lettino, Dejan Milašinović, C P Gale, Alec Vahanian, Andrzej Budaj, N. Dagres, Nicolas Danchin, Victoria Delgado, Jonathan Emberson, Örjan Friberg, Chris P Gale, Guy R. Heyndrickx, Bernard Iung, Stefan James, A P Kappetein, Aldo P. Maggioni, Nikos Maniadakis, Klaudia Vivien Nagy, G Parati, A-S Petronio, Mikko Pietilä, E Prescott, F Ruschitzka, Frans Van de Werf, Franz Weidinger, Uwe Zeymer, Chris P Gale, B Beleslin, Andrzej Budaj, Ovidiu Chioncel, N. Dagres, Nicolas Danchin, Jonathan Emberson, David Erlinge, M Glikson, A Gray, Meral Kayıkçıoğlu, Aldo P. Maggioni, Klaudia Vivien Nagy, А. О. Недошивин, A-P Petronio, J W Roos-Hesselink, L Wallentin, Uwe Zeymer, Bogdan A. Popescu, David Adlam, Alida L.P. Caforio, D Capodanno, Marc R. Dweck, David Erlinge, M Glikson, J Hausleiter, Bernard Iung, Meral Kayıkçıoğlu, Peter Ludman, Lars H. Lund, Aldo P. Maggioni, С.Т. Мацкеплишвили, Benjamin Meder, Klaudia Vivien Nagy, А. О. Недошивин, D Neglia, Agnès Pasquet, J W Roos-Hesselink, Fernando J. Rossello, Sameh Shaheen, Aleksandra Torbica, Chris P Gale, Peter Ludman, Maddalena Lettino, Héctor Bueno, Kurt Huber, Sergio Leonardi, Andrzej Budaj, Dejan Milašinović, Salvatore Brugaletta, Yolande Appelman, Vijay Kunadian, Wael Abdul Rahman Al Mahmeed, H Kzhdryan, Carlos Dumont, Alexander Geppert, Nirvana Šabanović-Bajramović, Fathima Aaysha Cader, Christophe Beauloye, Daniel Quesada, Ota Hlinomaz, Christoph Liebetrau, Toomas Marandi, Khaled Shokry, Héctor Bueno, Jacques Mansourati, Chris P Gale, David Maisuradze, Theodoros Sinanis, Surya Dharma, Katia Orvin, Ajay Sinha, Hasan Ali Farhan, Parham Sadeghipour, Ingibjörg Guđmundsdóttir, Ciro Indolfi, Takeshi Kitai, Erkin М Мirrakhimov, Olivija Gustienė, Philippe François, Andrejs Ērglis, M Popovici, Oliver Kalpak, Mungunchimeg Dagva, Robert G. Xuereb, Wan Azman Wan Ahmad, Yolande Appelman, Sunil Nadar, Nadeem Qamar, Marek Gierlotka, Sílvia Monteiro, Gheorghe‐Andrei Dan, Mina Radovanović, Е. В. Резник, Mohammed Balghith, Awad Mohamed, Miha Čerček, Denisa Brozmannová, Vedat Aytekin, Prossie Merab Ingabire, Baxrom Alyavi, L Cartasegna, V Nomberto Gomez, C Beltrano, V Novas, Carlos Dumont, H Balparda, Magnolia Cardona, Claudio Cigalini, Victoria Hoyle, E.S.C. Damaso, Vilma Tapia, K Poghosyan, Sergey Mkhitaryan, M. Adamyan, S Boyadjian, Hamlet Hayrapetyan, K. K. Azaryan, M. Ya. Tadevosyan, Hermine Poghosyan, H Kzhdryan, A. V. Vardanyan, Kurt Huber, Alexander Geppert, Adham Ahmed, Franz Weidinger, Michael Derntl, Matthias Hasun, T Schuh-Eiring, Lucia Riegler, Masud Haq, F A Cader, M A-M Dewan, M-E Fatema, Ahmedyar Hasan, Md Mainul Islam, F Khandoker, Rita Mayedah, Sharmin Nizam, Mohammad Azam, M M Arefin, J Jahan, Dan Schelfaut, Herbert De Raedt, Stijn Wouters, Stein Aerts, H Batjoens, Christophe Beauloye, Mélanie Dechamps, S Pierard, Olivier Van Caenegem, F Sinnaeve, Marc J. Claeys, M Snepvangers, Virend K. Somers, Sofie Gevaert, H Schaubroek, Pieter Vervaet, Marie Buysse, Frank Renders, Michiel Dumoulein, Nick Hiltrop, M De Coninck, S Naessens, I Senesael, E Hoffer, Suzanne Pourbaix, Jean‐François Beckers, Christophe Dugauquier, Sandrine Jacquet, D Malmendier, M Massoz, P Evrard, Laure Collard, Paul H. Brunner, Stéphane Carlier, Marianne Blockmans, Darren J. Mayne, E Timiras, Antoine Guédès, Fabian Demeure, Claude Hanet, J Domange, K Jourdan, Edin Begić, F Custović, Ada Đozić, E Hrvat, I Kurbasic, Denis Mačkić, Anela Šubo, Azra Durak-Nalbantić, Alen Džubur, Damir Rebić, Aida Hamzić-Mehmedbašić, Amila Redzepovic, A Djokic-Vejzovic, E Hodzić, Mirad Hujdur, Ehlimana Mušija, Z Gljiva-Gogic, Nafija Serdarević, Nermina Bajramović, Lejla Brigić, Mirela Halilčević, M Cibo, N. Hadzibegic, Nihad Kukavica, Alden Begić, Amer Iglica, Armin Osmanagic, Nerma Resić, M Grgurević, Faris Zvizdić, Belma Pojskić, Ekrema Mujarić, H. Selimovic, Malik Ejubović, L. Pojskic, E. Stimjanin, Michał Sut, Paola Zapata, C Gallego Munoz, L A Fajardo Andrade, M P Tobon Upegui, Lia Perez, Jorge Chavarría, Daniel Quesada, Kim Alvarado, Luka Zaputović, Vjekoslav Tomulić, David Gobić, Tomislav Jakljević, Dzenan Lulic, Goran Bačić, Luka Bastiančić, P Avraamides, Christos Eftychiou, Nicolaos Eteocleous, Adam Ioannou, C Lambrianidi, Michail Drakomathioulakis, Ladislav Groch, Ota Hlinomaz, M Rezek, Jiří Seménka, Jan Sitar, M Beranová, P Kramarikova, Ladislav Pešl, S Sindelárová, F Toušek, Hazem M. Warda, Inas S. Ghaly, Samer Habiba, A.K.M. Ahsan Habib, Michael Gergis, Hesham Bahaa, Ahmad Samir, H. Taha, M Adel,
Abstract Aims The European Society of Cardiology (ESC) EURObservational Research Programme (EORP) Non-ST-segment elevation myocardial infarction (NSTEMI) Registry aims to identify international patterns in NSTEMI management in clinical practice and outcomes against the 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without ST-segment-elevation. Methods and results Consecutively hospitalised adult NSTEMI patients (n = 3620) were enrolled between 11 March 2019 ...
Oxford University Press
Produção Nacional
Revisado por pares
Kaveh Edalati, Anwar Q. Ahmed, Saeid Akrami, Kei Ameyama, В. Н. Аптуков, Rashid Asfandiyarov, Maki Ashida, В. В. Астанин, Andrea Bachmaier, V. А. Beloshenko, Elena V. Bobruk, Krzysztof Bryła, José-María Cabrera, Amanda P. Carvalho, Nguyen Q. Chinh, Inchul Choi, R. Chulist, Jorge M. Cubero‐Sesin, Gregory Davdian, M. Demirtas, Sergiy V. Divinski, Karsten Durst, Jiří Dvořák, Parisa Edalati, Satoshi Emura, Nariman A. Enikeev, Ghader Faraji, Roberto B. Figueiredo, Ricardo Floriano, Marjan Fouladvind, D. Fruchart, Masayoshi Fuji, Hiroshi Fujiwara, Marcell Gajdics, Diana Gheorghe, Ł. Gondek, Joaquín E. González-Hernández, А. С. Горнакова, Thierry Grosdidier, Jenő Gubicza, Д. В. Гундеров, Liqing He, Óscar Fabián Higuera Cobos, Shoichi Hirosawa, Anton Hohenwarter, Zenji Horita, Jelena Horky, Yi Huang, Jacques Huot, Yoshifumi Ikoma, Tatsumi Ishihara, Yulia Ivanisenko, Jae‐il Jang, Alberto Moreira Jorge, Mie Kawabata-Ota, Megumi Kawasaki, Tarek Khelfa, Junya Kobayashi, Lembit Kommel, Anna Korneva, Pétr Král, Natalia Kudriashova, Shigeru Kuramoto, Terence G. Langdon, Dong-Hyun Lee, Valery I. Levitas, Cong Li, Haiwen Li, Yongtao Li, Li Zheng, Huaijun Lin, Klaus‐Dieter Liss, Ying Liu, Diana Maritza Marulanda Cardona, Kenji Matsuda, Andrey Mazilkin, Yoji Mine, Hiroyuki Miyamoto, Suk-Chun Moon, Timo Müller, Jairo Alberto Muñoz, M. Yu. Murashkin, Muhammad Naeem, Marc Novelli, Dániel Olasz, Reinhard Pıppan, V. V. Popov, Е. Н. Попова, G. Pürçek, Patricia de Rango, Oliver Renk, Delphine Retraint, Ádám Révész, Virginie Roche, Pablo Rodríguez-Calvillo, L. Romero-Reséndiz, Xavier Sauvage, Takahiro Sawaguchi, Hadi Sena, Hamed Shahmir, Xiaobin Shi, V. Sklenička, Werner Skrotzki, Nataliya Skryabina, Franziska Staab, Boris B. Straumal, Zhidan Sun, M.J. Szczerba, Yoichi Takizawa, Yongpeng Tang, Р. З. Валиев, Alina Vozniak, Andrei Voznyak, Bo Wang, Jing Tao Wang, Gerhard Wilde, Fan Zhang, Meng Zhang, Peng Zhang, Jianqiang Zhou, Xinkun Zhu, Yuntian Zhu,
Ultrafine-grained and heterostructured materials are currently of high interest due to their superior mechanical and functional properties. Severe plastic deformation (SPD) is one of the most effective methods to produce such materials with unique microstructure-property relationships. In this review paper, after summarizing the recent progress in developing various SPD methods for processing bulk, surface and powder of materials, the main structural and microstructural features of SPD-processed ...
Tópico(s): High Entropy Alloys Studies
2024 - Elsevier BV | Journal of Alloys and Compounds
Marius Maximilian Woitok, Fabian Kießling, Francisco Javier Cubero, Christian Trautwein, Dennis Doleschel, Wiltrud Lederle, Miguel Eugenio Zoubek,
Tópico(s): Cell death mechanisms and regulation
2017 - Lippincott Williams & Wilkins | Hepatology
Ramesh Nadarajah, Peter Ludman, Cécile Laroche, Yolande Appelman, Salvatore Brugaletta, Andrzej Budaj, Héctor Bueno, Kurt Huber, Vijay Kunadian, Sergio Leonardi, Maddalena Lettino, Dejan Milašinović, Chris P Gale, Alec Vahanian, Andrzej Budaj, N. Dagres, Nicolas Danchin, Victoria Delgado, Jonathan Emberson, Örjan Friberg, C P Gale, Guy R. Heyndrickx, Bernard Iung, Stefan James, A P Kappetein, Aldo P. Maggioni, Nikos Maniadakis, Klaudia Vivien Nagy, G Parati, A-S Petronio, Mikko Pietilä, E Prescott, F Ruschitzka, Frans Van de Werf, Franz Weidinger, Uwe Zeymer, Chris P Gale, B Beleslin, Andrzej Budaj, Ovidiu Chioncel, N. Dagres, Nicolas Danchin, Jonathan Emberson, David Erlinge, M Glikson, A Gray, Meral Kayıkçıoğlu, Aldo P. Maggioni, Klaudia Vivien Nagy, А. О. Недошивин, A-P Petronio, J W Roos-Hesselink, L Wallentin, Uwe Zeymer, Bogdan A. Popescu, David Adlam, Alida L.P. Caforio, D Capodanno, Marc R. Dweck, David Erlinge, M Glikson, J Hausleiter, Bernard Iung, Meral Kayıkçıoğlu, Peter Ludman, Lars Christian Lund, Aldo P. Maggioni, С.Т. Мацкеплишвили, Benjamin Meder, Klaudia Vivien Nagy, А. О. Недошивин, D Neglia, Agnès Pasquet, J W Roos-Hesselink, Fernando J. Rossello, Sameh Shaheen, Aleksandra Torbica, Chris P Gale, Peter Ludman, Maddalena Lettino, Héctor Bueno, Kurt Huber, Sergio Leonardi, Andrzej Budaj, Dejan Milašinović, Salvatore Brugaletta, Yolande Appelman, Vijay Kunadian, Wael Abdul Rahman Al Mahmeed, H Kzhdryan, Carlos Dumont, Alexander Geppert, Nirvana Šabanović-Bajramović, Fathima Aaysha Cader, Christophe Beauloye, Daniel Quesada, Ota Hlinomaz, Christoph Liebetrau, Toomas Marandi, Khaled Shokry, Héctor Bueno, Jacques Mansourati, Chris P Gale, David Maisuradze, Theodoros Sinanis, Surya Dharma, Katia Orvin, Ajay Sinha, Hasan Ali Farhan, Parham Sadeghipour, Ingibjörg Guđmundsdóttir, Ciro Indolfi, Takeshi Kitai, Erkin М Мirrakhimov, Olivija Gustienė, Philippe François, Andrejs Ērglis, M Popovici, Oliver Kalpak, Mungunchimeg Dagva, Robert G. Xuereb, Wan Azman Wan Ahmad, Yolande Appelman, Sunil Nadar, Nadeem Qamar, Marek Gierlotka, Sílvia Monteiro, Gheorghe‐Andrei Dan, Mina Radovanović, Е. В. Резник, Mohammed Balghith, Awad Mohamed, Miha Čerček, Denisa Brozmannová, Vedat Aytekın, Prossie Merab Ingabire, Baxrom Alyavi, L Cartasegna, V Nomberto Gomez, C Beltrano, V Novas, Carlos Dumont, H Balparda, Magnolia Cardona, Claudio Cigalini, Victoria Hoyle, E.S.C. Damaso, Vilma Tapia, K Poghosyan, Sergey Mkhitaryan, M. Adamyan, S Boyadjian, Hamlet Hayrapetyan, K. K. Azaryan, M. Ya. Tadevosyan, Hermine Poghosyan, H Kzhdryan, A. V. Vardanyan, Kurt Huber, Alexander Geppert, Adham Ahmed, Franz Weidinger, Michael Derntl, Matthias Hasun, T Schuh-Eiring, Lucia Riegler, Masud Haq, F A Cader, M A-M Dewan, M-E Fatema, Ahmedyar Hasan, Md Mainul Islam, F Khandoker, Rita Mayedah, Sharmin Nizam, Mohammad Azam, M M Arefin, J Jahan, Dan Schelfaut, Herbert De Raedt, Stijn Wouters, Stein Aerts, H Batjoens, Christophe Beauloye, Mélanie Dechamps, S Pierard, Olivier Van Caenegem, F Sinnaeve, Marc J. Claeys, M Snepvangers, Virend K. Somers, Sofie Gevaert, H Schaubroek, Pieter Vervaet, Marie Buysse, Frank Renders, Michiel Dumoulein, Nick Hiltrop, M De Coninck, S Naessens, I Senesael, E Hoffer, Suzanne Pourbaix, Jean‐François Beckers, Christophe Dugauquier, Sandrine Jacquet, D Malmendier, M Massoz, P Evrard, Laure Collard, Paul H. Brunner, Stéphane Carlier, Marianne Blockmans, Darren J. Mayne, E Timiras, Antoine Guédès, Fabian Demeure, Claude Hanet, J Domange, K Jourdan, Edin Begić, F Custović, Ada Đozić, E Hrvat, I Kurbasic, Denis Mačkić, Anela Šubo, Azra Durak-Nalbantić, Alen Džubur, Damir Rebić, Aida Hamzić-Mehmedbašić, Amila Redzepovic, A Djokic-Vejzovic, E Hodzić, Mirad Hujdur, Ehlimana Mušija, Z Gljiva-Gogic, Nafija Serdarević, Nermina Bajramović, Lejla Brigić, Mirela Halilčević, M Cibo, N. Hadzibegic, Nihad Kukavica, Alden Begić, Amer Iglica, Armin Osmanagic, Nerma Resić, M Grgurević, Faris Zvizdić, Belma Pojskić, Ekrema Mujarić, H. Selimovic, Malik Ejubović, L. Pojskic, E. Stimjanin, Michał Sut, Paola Zapata, C Gallego Munoz, L A Fajardo Andrade, M P Tobon Upegui, Lia Perez, Jorge Chavarría, Daniel Quesada, Kim Alvarado, Luka Zaputović, Vjekoslav Tomulić, David Gobić, Tomislav Jakljević, Dzenan Lulic, Goran Bačić, Luka Bastiančić, P Avraamides, Christos Eftychiou, Nicolaos Eteocleous, Adam Ioannou, C Lambrianidi, Michail Drakomathioulakis, Ladislav Groch, Ota Hlinomaz, M Rezek, Jiří Seménka, Jan Sitar, M Beranová, P Kramarikova, Ladislav Pešl, S Sindelárová, F Toušek, Hazem M. Warda, Inas S. Ghaly, Samer Habiba, A.K.M. Ahsan Habib, Michael Gergis, Hesham Bahaa, Ahmad Samir, H. Taha,
The majority of NSTEMI burden resides outside high-income countries (HICs). We describe presentation, care, and outcomes of NSTEMI by country income classification.
Oxford University Press
MM Woitok, Dennis Doleschel, ME Zoubek, Fabian Kießling, Wiltrud Lederle, FJ Cubero, Christian Trautwein,
The prevalence of non-alcoholic fatty liver disease (NAFLD), including the more aggressive non-alcoholic steatohepatitis (NASH) is continuously increasing in developed countries, associated with major complications due to cirrhosis and end-stage hepatocellular carcinoma (HCC). The c-Jun N-terminal kinases (JNKs) play a crucial role in liver physiology and disease pathogenesis. In the present study, we aimed to investigate the relevance of hepatocyte-specific Jnk2 inhibition in an experimental model ...
Tópico(s): Melanoma and MAPK Pathways
2019 - Thieme Medical Publishers (Germany) | Zeitschrift für Gastroenterologie
Marius Maximilian Woitok, Dennis Doleschel, Miguel Eugenio Zoubek, Wiltrud Lederle, Fabian Kießling, Christian Trautwein, F.J. Cubero,
Tópico(s): Liver physiology and pathology
2018 - Elsevier BV | Journal of Hepatology
Marius Maximilian Woitok, Miguel Eugenio Zoubek, Dennis Doleschel, Fabian Kießling, Wiltrud Lederle, Christian Trautwein, Francisco Javier Cubero,
Tópico(s): Cancer Mechanisms and Therapy
2019 - Elsevier BV | Journal of Hepatology
Marius Maximilian Woitok, Dennis Doleschel, Miguel Eugenio Zoubek, Fabian Kießling, Wiltrud Lederle, Christian Trautwein, F.J. Cubero,
Tópico(s): Liver physiology and pathology
2017 - Elsevier BV | Journal of Hepatology
FJ Cubero, Gang Zhao, Yulia A. Nevzorova, M. Al Masaoudi, Julien Verdier, Peng Jiang, F. Schaefer, Maximilian Hatting, N. Hermanns, M.V. Boekschoten, Christoph Grouls, Nikolaus Gaßler, Fabian Kießling, M Müller, Christian Liedtke, Christian Trautwein,
Background & Aims: Currently the focus of future targeted therapy is to define novel pathways involved in the promotion of the survival and/or death of transformed hepatocytes and the control of their progression into HCC. Of particular interest is the interaction between mechanisms controlling NEMO, the regulatory subunit of NF-κB, and Jnk activation for directing cell death and survival. In the present study, we aimed to define the relevance of Jnk in hepatocyte-specific NEMO knockout mice (NEMOΔhepa), ...
Tópico(s): interferon and immune responses
2014 - Thieme Medical Publishers (Germany) | Zeitschrift für Gastroenterologie
F.J. Cubero, Guoqiang Zhao, Yulia A. Nevzorova, M. Al Masaoudi, Julien Verdier, Jianjun Peng, Frederik M. Schaefer, Maximilian Hatting, N. Hermanns, M.V. Boekschoten, Christoph Grouls, N Gaßler, Fabian Kießling, Madeleine Müller, Roger J. Davis, Christian Liedtke, Christian Trautwein,
Tópico(s): Endoplasmic Reticulum Stress and Disease
2014 - Elsevier BV | Journal of Hepatology