Dionne Kringos, Fabrizio Carinci, Erica Barbazza, Véronique Bos, Kendall Jamieson Gilmore, Oliver Groene, László Gulàcsi, Damir Ivanković, Tessa Jansen, Søren Paaske Johnsen, Simon de Lusignan, Jan Mainz, Sabina Nuti, Niek Klazinga, Petra Baji, Óscar Brito Fernandes, Pinar Kara, Nicolás Larrain, Beatriz Meza, Anna Maria Murante, Márta Péntek, Mircha Poldrugovac, S. Wang, Claire Willmington, Yuanhang Yang,
Abstract Background The COVID-19 pandemic is a complex global public health crisis presenting clinical, organisational and system-wide challenges. Different research perspectives on health are needed in order to manage and monitor this crisis. Performance intelligence is an approach that emphasises the need for different research perspectives in supporting health systems’ decision-makers to determine policies based on well-informed choices. In this paper, we present the viewpoint of the Innovative ...
Tópico(s): Healthcare Operations and Scheduling Optimization
2020 - BioMed Central | Health Research Policy and Systems
Erica Barbazza, Damir Ivanković, К. V. Davtyan, Mircha Poldrugovac, Zhamin Yelgezekova, Claire Willmington, Bernardo Meza-Torres, Véronique Bos, Óscar Brito Fernandes, Alexandru Rotar, Sabina Nuti, Milena Vainieri, Fabrizio Carinci, Natasha Azzopardi‐Muscat, Oliver Groene, David Novillo-Ortiz, Niek Klazinga, Dionne Kringos,
Governments across the World Health Organization (WHO) European Region have prioritised dashboards for reporting COVID-19 data. The ubiquitous use of dashboards for public reporting is a novel phenomenon.
Tópico(s): COVID-19 epidemiological studies
2022 - SAGE Publishing | Digital Health
Hoang Oanh Nguyen, Tiziana Schioppa, Laura Tiberio, Fabrizio Facchinetti, Gino Villetti, Maurizio Civelli, Annalisa Del Prete, Francesca Sozio, Carolina Gaudenzi, Mauro Passari, Ilaria Barbazza, Silvano Sozzani, Valentina Salvi, Daniela Bosisio,
Phosphodiesterase 4 (PDE4) inhibitors are immunomodulatory drugs approved to treat diseases associated with chronic inflammatory conditions, such as COPD, psoriasis and atopic dermatitis. Tanimilast (international non-proprietary name of CHF6001) is a novel, potent and selective inhaled PDE4 inhibitor in advanced clinical development for the treatment of COPD. To begin testing its potential in limiting hyperinflammation and immune dysregulation associated to SARS-CoV-2 infection, we took advantage ...
Tópico(s): Vagus Nerve Stimulation Research
2022 - Frontiers Media | Frontiers in Immunology
Tiziana Schioppa, Hoang Oanh Nguyen, Valentina Salvi, Norma Maugeri, Fabrizio Facchinetti, Gino Villetti, Maurizio Civelli, Carolina Gaudenzi, Mauro Passari, Francesca Sozio, Ilaria Barbazza, Nicola Tamassia, Marco A. Cassatella, Annalisa Del Prete, Daniela Bosisio, Laura Tiberio,
Neutrophils, the most abundant subset of leukocytes in the blood, play a pivotal role in host response against invading pathogens. However, in respiratory diseases, excessive infiltration and activation of neutrophils can lead to tissue damage. Tanimilast-international non-proprietary name of CHF6001-is a novel inhaled phosphodiesterase 4 (PDE4) inhibitor in advanced clinical development for the treatment of chronic obstructive pulmonary disease (COPD), a chronic inflammatory lung disease where neutrophilic ...
Tópico(s): S100 Proteins and Annexins
2022 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Hoang Oanh Nguyen, Valentina Salvi, Laura Tiberio, Fabrizio Facchinetti, Mirco Govoni, Gino Villetti, Maurizio Civelli, Ilaria Barbazza, Carolina Gaudenzi, Mauro Passari, Tiziana Schioppa, Francesca Sozio, Annalisa Del Prete, Silvano Sozzani, Daniela Bosisio,
Abstract Background Tanimilast is a novel and selective inhaled inhibitor of phosphodiesterase-4 in advanced clinical development for chronic obstructive pulmonary disease (COPD). Tanimilast is known to exert prominent anti-inflammatory activity when tested in preclinical experimental models as well as in human clinical studies. Recently, we have demonstrated that it also finely tunes, rather than suppressing, the cytokine network secreted by activated dendritic cells (DCs). This study was designed ...
Tópico(s): Phosphodiesterase function and regulation
2022 - BioMed Central | Journal of Translational Medicine
Carlo Alberto Manzo, Alfredo Annicchiarico, Sayali Valiyeva, Arcangelo Picciariello, Adriana Gallotta, Agnese Dezi, Alba Oliva, Alberto Brun Peressut, Alberto Gerundo, Alberto Stocco, Alessandra Ida, Alessandra Marello, Alessandro Bonomi, Alessandro Borelli, Alessandro Izzo, Alessandro Soave, Alessia Chini, Alessio Impagnatiello, Alessio Maurelli, Alfonso Amendola, Alfredo Annicchiarico, Amedeo Antonelli, Andrea Fares Bucci, Andrea Grego, Andrea Lovece, Andrea Martina Guida, Andrea Micalef, Andrea Morini, Andrea Quazzico, Andrea Romboli, Andrea Scardino, Andrea Zironda, Andrea‐Pierre Luzzi, Angelo Alessandro Marra, Angelo Gabriele Epifani, Anna D’Amore, Annalisa Barbazza, Annalisa Comandatore, Antonella Grasso, Antonia Lavinia Zuliani, Antonino Esposito, Antonio Alvigi, Antonio Castaldi, Antonio Farro, Antonio Franzese, Antonio R. Gargiulo, Arcangelo Picciariello, Arianna Petrungaro, Barbara Vercellone, Beatrice De Zolt, Beatrice Drago, Beatrice Salmaso, Beatrice Sperotto, Beatrice Torre, Beatrice Zamburlini, Bianca Angelone, Brunella Maria Pirozzi, Camilla Gasparini, Camilla Nacci, Carlo Alberto Manzo, Giovanni Ferrari, Carlo Giove, Carlo Serra, Carmen Sorrentino, Carolina Bartolini, Carolina Rubicondo, Casoni Pattacini Gianmaria, Caterina Baldi, Caterina Lastraioli, Cayerina Froiio, Chiara Caricato, Chiara Cipressi, Chiara Marafante, Cinzia Bottalico, Cinzia Tanda, Claudia Antonella Martino, Claudia Armellin, Claudio Cimmino, Claudio Guerci, Cristina Larotonda, Dajana Glavas, Daniele Fusario, Daniele Morezzi, Daniele Passannanti, Daniele Sambucci, Daniele Zigiotto, Dario Rosini, Dario Vergari, Dario Zansavio, David Tumiati, Davide Ferrari, De Flaviis Mattia, Domenica Pignatelli, Domenico Piccione, Domenico Vita, Dorena Caruso, Edmondo Rastelli, Elena Herranz van Nood, Elisa Galasso, Elisa Mina, Elisa Romandini, Elsa Beltrami, Emanuele Caruso, Emanuele Doria, Enrica Esposito, Enrico Pinotti, Erica Monati, Erika Boriani, Ester Marra, Ezio Lombardo, Fabio Ambrosini, Fabio Carbone, Fabrizio Aquilino, Fabrizio Perrone, Federica Cavalera, F. De Robertis, Federica Del Coco, Federica Zarcone, Federico Manetti, Federico Maria D’Alessio, Felicia Fiore, Filippo Caminati, Francesca Albanesi, Francesca Ascari, Francesca Calemma, Francesca Lo Celso, Francesca Maria Chiara Savasta, Francesca Paola Tropeano, Francesca Pegoraro, Francesca Serio, Francesco Bianco, Francesco Cammarata, Francesco Cappabianca, Francesco Carenini, Francesco Cobellis, F. Romano, Francesco Menegon Tasselli, Francesco Milardi, Francesco Moroni, Franco Sacchetti, Gabriele Barletta, Gabriele Bislenghi, Gabriele Luciano Petracca, Gabriele Vago, Gabriella De Santi, Gabriella Lionetto, Gaia Colletti, Gaia Zagolin, Gennaro Giovine, Gerardo Palmieri, Gerti Dajti, Giacomo Carganico, Giacomo Fuschillo, Giacomo Mascheri, Gian Luigi Canu, G Baronio, Gianluca Benassai, G Fucci, Gianmario Edoardo Poto, Gianni Versari, Gilda De Paola, Giorgia Grillea, Giorgio Crocetti, Giorgio Dalmonte, Giorgio Lisi, Giorgio Micheletti, Giovanna Berardi, Giovanna Di Scanno, Giovanna Pavone, Giovanni Castagna, Giovanni Spiezio, G. Tomasicchio, Giulia Cerino, Giulia Citrigno, Giulia I. L. Mottola, Giulia Negro, Giulia Turri, Giuliano Lantone, Giuseppe Palomba, Giuseppe Sorrentino, Giuseppe Trigiante, Giustina Angellotti, G. Biasi, Grazia Cantore, Gregorio Romeo, Greta Bracchetti, Guenda Pulcina, Guglielmo Clarizia, Guglielmo Guerrazzi, Guglielmo Niccolò Piozzi, Helen Yu, Hila Jozel, Ilaria Ferrante, Irma Vece, Isabella Pezzoli, Jacopo Nicolò Marin, Juhye Jeong, Katia Di Lauro, Kinga Agnieszka Folcik, Krizia Aquilino, Laura Addari, Laura Benuzzi, Laura Francesca Angelicchio, Leandro Siragusa, L. Lorusso, Letizia Santandrea, Livio Ludici, Lorenzo Epis, Lorenzo Gallitiello, Lorenzo Macone, Lorenzo Pagliai, Lorenzo Petagna, Lorenzo Tosi, Lorenzo Vona, L Bonomo, Luca Ferrario, Luca Perin, Luca Resca, Luca Salvador, Luca Scaravilli, Luca Sullo, Luca Tirloni, Lucia Ballabeni, Lucia Romano, Ludovica Baldari, Ludovica Vacca, L. Carbone, Luigi Cayre, Maddalena Maria Bignone, Manuela Mastronardi, Manuela Mercurio, Mara Sblendorio, Marco Maione, Marco Materazzo, M. Luc, Marco Varesano, Maria Cigognini, Maria Di Salvo, Maria Francesca Chiappetta, Maria Martina Fierro, Maria Sara Santicchia, Marianna Capuano, Marianna Matacena, Mariantonietta Alagia, Mario Giuffrida, Mario Pacilli, Marta Breda, Marta Goglia, Marta Maistri, Marta Perego, Martina Mariatti, Martina Pontillo, Martina Sironi, Marzia Franceschilli, Marzia Tripepi, Matteo Calì, Matteo Montenovo, Matteo Papandrea, Matteo Pollastro, Matteo Rossini, Mattia Marinelli, Mauro Montuori, Michela Campanelli, Michele Bellofiore, Michele Cricrì, Michele Guido Podda, Michele Manara, Michele Manigrasso, Michele Rispoli, Miriam Biancu, Nick Salimian, Nicola Musa, Nicola Paradiso, Nicolò De Santis, Nicolò Maria Barabino, Nunzia Ivana Conversano, Nunzio Spagnoli, Nunzio Velotti, Pamela Milito, Paola Batistotti, Paola Mercurio, Paolo Pizzini, Pasquale Losurdo, Pierantonio Cardinale, Pietro Anoldo, Raffaele Basile, Raffaele De Filippi, Riccardo Marsengo, Rigers Dibra, Rita Laforgia, Roberta Odorizzi, Roberto Santalucia, Rocco Aversa, Rosa Maione, Rosalinda Filippo, Sabino Capuzzolo,
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Carlo Alberto Manzo, Alfredo Annicchiarico, Sayali Valiyeva, Arcangelo Picciariello, Adriana Gallotta, Agnese Dezi, Alba Oliva, Alberto Brun Peressut, Alberto Gerundo, Alberto Stocco, Alessandra Ida, Alessandra Marello, Alessandro Bonomi, Alessandro Borelli, Alessandro Izzo, Alessandro Soave, Alessia Chini, Alessio Impagnatiello, Alessio Maurelli, Alfonso Amendola, Alfredo Annicchiarico, Amedeo Antonelli, Andrea Fares Bucci, Andrea Grego, Andrea Lovece, Andrea Martina Guida, Andrea Micalef, Andrea Morini, Andrea Quazzico, Andrea Romboli, Andrea Scardino, Andrea Zironda, Andrea‐Pierre Luzzi, Angelo Alessandro Marra, Angelo Gabriele Epifani, Anna D’Amore, Annalisa Barbazza, Annalisa Comandatore, Antonella Grasso, Antonia Lavinia Zuliani, Antonino Esposito, Antonio Alvigi, Antonio Castaldi, Antonio Farro, Antonio Franzese, Antonio R. Gargiulo, Arcangelo Picciariello, Arianna Petrungaro, Barbara Vercellone, Beatrice De Zolt, Beatrice Drago, Beatrice Salmaso, Beatrice Sperotto, Beatrice Torre, Beatrice Zamburlini, Bianca Angelone, Brunella Maria Pirozzi, Camilla Gasparini, Camilla Nacci, Carlo Alberto Manzo, Giovanni Ferrari, Carlo Giove, Carlo Serra, Carmen Sorrentino, Carolina Bartolini, Carolina Rubicondo, Casoni Pattacini Gianmaria, Caterina Baldi, Caterina Lastraioli, Cayerina Froiio, Chiara Caricato, Chiara Cipressi, Chiara Marafante, Cinzia Bottalico, Cinzia Tanda, Claudia Antonella Martino, Claudia Armellin, Claudio Cimmino, Claudio Guerci, Cristina Larotonda, Dajana Glavas, Daniele Fusario, Daniele Morezzi, Daniele Passannanti, Daniele Sambucci, Daniele Zigiotto, Dario Rosini, Dario Vergari, Dario Zansavio, David Tumiati, Davide Ferrari, De Flaviis Mattia, Domenica Pignatelli, Domenico Piccione, Domenico Vita, Dorena Caruso, Edmondo Rastelli, Elena Herranz van Nood, Elisa Galasso, Elisa Mina, Elisa Romandini, Elsa Beltrami, Emanuele Caruso, Emanuele Doria, Enrica Esposito, Enrico Pinotti, Erica Monati, Erika Boriani, Ester Marra, Ezio Lombardo, Fabio Ambrosini, Fabio Carbone, Fabrizio Aquilino, Fabrizio Perrone, Federica Cavalera, F. De Robertis, Federica Del Coco, Federica Zarcone, Federico Manetti, Federico Maria D’Alessio, Felicia Fiore, Filippo Caminati, Francesca Albanesi, Francesca Ascari, Francesca Calemma, Francesca Lo Celso, Francesca Maria Chiara Savasta, Francesca Paola Tropeano, Francesca Pegoraro, Francesca Serio, Francesco Bianco, Francesco Cammarata, Francesco Cappabianca, Francesco Carenini, Francesco Cobellis, F. Romano, Francesco Menegon Tasselli, Francesco Milardi, Francesco Moroni, Franco Sacchetti, Gabriele Barletta, Gabriele Bislenghi, Gabriele Luciano Petracca, Gabriele Vago, Gabriella De Santi, Gabriella Lionetto, Gaia Colletti, Gaia Zagolin, Gennaro Giovine, Gerardo Palmieri, Gerti Dajti, Giacomo Carganico, Giacomo Fuschillo, Giacomo Mascheri, Gian Luigi Canu, G Baronio, Gianluca Benassai, G Fucci, Gianmario Edoardo Poto, Gianni Versari, Gilda De Paola, Giorgia Grillea, Giorgio Crocetti, Giorgio Dalmonte, Giorgio Lisi, Giorgio Micheletti, Giovanna Berardi, Giovanna Di Scanno, Giovanna Pavone, Giovanni Castagna, Giovanni Spiezio, G. Tomasicchio, Giulia Cerino, Giulia Citrigno, Giulia I. L. Mottola, G Negro, Giulia Turri, Giuliano Lantone, Giuseppe Palomba, Giuseppe Sorrentino, Giuseppe Trigiante, Giustina Angellotti, G. Biasi, Grazia Cantore, Gregorio Romeo, Greta Bracchetti, Guenda Pulcina, Guglielmo Clarizia, Guglielmo Guerrazzi, Guglielmo Niccolò Piozzi, Helen Yu, Hila Jozel, Ilaria Ferrante, Irma Vece, Isabella Pezzoli, Jacopo Nicolò Marin, Juhye Jeong, Katia Di Lauro, Kinga Agnieszka Folcik, Krizia Aquilino, Laura Addari, Laura Benuzzi, Laura Francesca Angelicchio, Leandro Siragusa, L. Lorusso, Letizia Santandrea, Livio Ludici, Lorenzo Epis, Lorenzo Gallitiello, Lorenzo Macone, Lorenzo Pagliai, Lorenzo Petagna, Lorenzo Tosi, Lorenzo Vona, L Bonomo, Luca Ferrario, Luca Perin, Luca Resca, Luca Salvador, Luca Scaravilli, Luca Sullo, Luca Tirloni, Lucia Ballabeni, Lucia Romano, Ludovica Baldari, Ludovica Vacca, L. Carbone, Luigi Cayre, Maddalena Maria Bignone, Manuela Mastronardi, Manuela Mercurio, Mara Sblendorio, Marco Maione, Marco Materazzo, M. Luc, Marco Varesano, Maria Cigognini, Maria Di Salvo, Maria Francesca Chiappetta, Maria Martina Fierro, Maria Sara Santicchia, Marianna Capuano, Marianna Matacena, Mariantonietta Alagia, Mario Giuffrida, Mario Pacilli, Marta Breda, Marta Goglia, Marta Maistri, Marta Perego, Martina Mariatti, Martina Pontillo, Martina Sironi, Marzia Franceschilli, Marzia Tripepi, Matteo Calì, Matteo Montenovo, Matteo Papandrea, Matteo Pollastro, Matteo Rossini, Mattia Marinelli, Mauro Montuori, Michela Campanelli, Michele Bellofiore, Michele Cricrì, Michele Guido Podda, Michele Manara, Michele Manigrasso, Michele Rispoli, Miriam Biancu, Nick Salimian, Nicola Musa, Nicola Paradiso, Nicolò De Santis, Nicolò Maria Barabino, Nunzia Ivana Conversano, Nunzio Spagnoli, Nunzio Velotti, Pamela Milito, Paola Batistotti, Paola Mercurio, Paolo Pizzini, Pasquale Losurdo, Pierantonio Cardinale, Pietro Anoldo, Raffaele Basile, Raffaele De Filippi, Riccardo Marsengo, Rigers Dibra, Rita Laforgia, Roberta Odorizzi, Roberto Santalucia, Rocco Aversa, Rosa Maione, Rosalinda Filippo, Sabino Capuzzolo,
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