Mary Brush Williams, Fannie Hurst, Ralph Barton, Finley Peter Dunne, Phyllis Duganne, Clarence Budington Kelland, Ethel Somers, Alva Taylor, Patricia, Eileen Bourne, Michael Arlen, Opie Read, Walter Davenport, Arthur Robinson,
... Encouragement from the Famous Humorist Auburn Automobile Company Fada Radio Zonite Flung Roses The Story of a ...
1926 - Gale Group | LibertyMagazine
Ming‐Hua Xu, Mitsunori Yamada, Li Mei, Hongqi Liu, Shu G. Chen, Yiping W. Han,
... including periodontal diseases and preterm birth. A novel FadA adhesin was recently identified for host-cell binding. ... an 18-amino acid signal peptide. Expression of FadA in Escherichia coli enhanced bacterial binding to host ... cells. In both E. coli and F. nucleatum, FadA exists in two forms, the intact pre-FadA and the secreted mature FadA (mFadA), with pre-FadA anchored in the inner membrane and mFadA secreted outside the bacteria. Pre-FadA and mFadA formed high M(r) complexes. When ... mFadA was soluble at neutral pH, whereas pre-FadA was insoluble. Pre-FadA became soluble when mixed ...
Tópico(s): Blood disorders and treatments
2007 - Elsevier BV | Journal of Biological Chemistry
Ethel Somers, Walter Davenport, Edna Wallace Hopper, Burns Mantle, Clarence Budington Kelland, E. R. B., Alva Taylor, Lillian Day, Ralph Barton, Hugh Fullerton, Achmed Abdullah, Brenda Ueland, Gerald R. Severn, P. G. Wodehouse, Mary Brush Williams, Finley Peter Dunne, Stephen Decatur, Patricia, Sid Sutherland, Eileen Bourne,
... Hair Marmola White Star Line Red Star Line Fada Radio Santa Fe How Much Happiness Can Millions ...
1926 - Gale Group | LibertyMagazine
J.-H. Yu, Jenny Wieser, Thomas H. Adams,
... identified a dominant mutation in a second gene, fadA, that resulted in a very similar phenotype to flbA loss-of-function mutants. Analysis of fadA showed that it encodes the alpha-subunit of ... resulted from conversion of glycine 42 to arginine (fadA(G42R)). This mutation is predicted to result in ... to proliferation and blocks sporulation. By contrast, a fadA deletion and a fadA dominant-interfering mutation (fadA(G203R)) resulted in reduced growth without impairing sporulation. In fact, the fadA(G203R) mutant was a hyperactive asexual sporulator and ...
Tópico(s): Enzyme Production and Characterization
1996 - Springer Nature | The EMBO Journal
Mary Brush Williams, Ralph Barton, Finley Peter Dunne, Phyllis Duganne, Hugh Fullerton, Arthur Somers Roche, Mabel McElliott Clarke, James O'donnell Bennett, Alva Taylor, Edwin Balmer, Jack O'Donnell, Beecher Edwards, Francis Ouimet,
... Lessons on the Way to the Golf Championship FADA Radio Liberty Magazine Colorado Impressions Fisk I Love ...
1926 - Gale Group | LibertyMagazine
Julie K. Hicks, Jae‐Hyuk Yu, Nancy P. Keller, Thomas H. Adams,
... and mycotoxin production both require inactivation of the FadA Gα protein-dependent signaling pathway Julie K. Hicks ... RGS domain protein, or dominant activating mutations in fadA, which encodes the α subunit of a heterotrimeric ... sporulation. Moreover, overexpression of flbA or dominant interfering fadA mutations cause precocious stc gene expression and ST ... production could be suppressed by loss-of-function fadA mutations. The ability of flbA to activate stc ... require inactivation of proliferative growth through inhibition of FadA-dependent signaling. This regulatory mechanism is conserved in ...
Tópico(s): Plant-Microbe Interactions and Immunity
1997 - Springer Nature | The EMBO Journal
Sax Rohmer, James G. Jackson, Mary Brush Williams, Inez Cunningham, Francis Ouimet, Ralph Barton, Finley Peter Dunne, Hugh Fullerton, Brenda Ueland, Mrs. Walter Johnson, Sophie Kerr, David Belasco, George K. Shaffer, Alva Taylor, Arthur Somers Roche, George B. Longan, Strickland Gillilan, Henry Kitchell Webster,
... Golden Glint Shampoo Blue=Jay Premier Electric Co. Fada Radio Kitchen Klenzer Detroit & Cleveland Navigation Company Pathex ...
1926 - Gale Group | LibertyMagazine
Mara Roxana Rubinstein, Jung Eun Baik, Stephen M. Lagana, Richard P Han, William J. Raab, Debashis Sahoo, Piero Dalerba, Timothy C. Wang, Yiping W. Han,
... of cancer stage, grade, age, and sex. The FadA adhesin from F. nucleatum up-regulates Annexin A1 ... through E-cadherin. A positive feedback loop between FadA and Annexin A1 is identified in the cancerous ... a predictor of poor prognosis. The Fusobacterium nucleatum FadA adhesin up-regulates Annexin A1 expression through E-cadherin. A positive feedback loop between FadA and Annexin A1 is specifically present in cancer ... F. nucleatum promotes CRC growth through its unique FadA adhesin, which binds to E-cadherin (CDH1) and ...
Tópico(s): S100 Proteins and Annexins
2019 - Springer Nature | EMBO Reports
Photograph. Photograph of Highland Cattle in Loch Fada. Charles Reid. Photographer: Charles Reid.
0000 - Gale Group | NCCO Photography
Qing H. Meng, Qiuqiang Gao, Shebli Mehrazarin, Kamonchanok Tangwanichgapong, Yu Wang, Yiming Huang, Yutong Pan, Samuel T. Robinson, Ziwen Liu, Amirali Zangiabadi, Renate Lux, Panos N. Papapanou, Xiao Guo, Harris H. Wang, Luke E. Berchowitz, Yiping W. Han,
... Source DataTransparent process Fusobacterium nucleatum secretes amyloid-like FadA to enhance pathogenicity Qing Meng Qing Meng Section ... pathogen. We report that Fn secretes an adhesin (FadA) with amyloid properties via a Fap2-like autotransporter to enhance its virulence. The extracellular FadA binds Congo Red, Thioflavin-T, and antibodies raised against human amyloid β42. Fn produces amyloid-like FadA under stress and disease conditions, but not in ... Fn binding to host cells. Furthermore, amyloid-like FadA induces periodontal bone loss and promotes CRC progression ...
Tópico(s): Oral microbiology and periodontitis research
2021 - Springer Nature | EMBO Reports
Frances Gibb, Legal Affairs Correspondent, Juan Carlos Gumucio, Mark Dowd Education Reporter, Simon O'Hagan, Martin Gilbert, Frank Johnson, Richard Thomson Banking Correspondent, J. B. Curtiss, Director, Richard Pawson, Ivo Tennant, Ian McLauchlan, Gavin Bell Arts Correspondent, Ian Murray, Michael Binyon, Richard Fairman, Carol Leonard, M. Hensman, Richard Streeton, Richard Eaton, John Clare, Education Correspondent, Michael McCarthy, S. P., John Newell, Robert Miller, David R. Bates, Mitchell Platts, Roger Lean-Vercoe, John Rae, Michael Tate, Walter Sullivan, Norman Hammond, Archaeology Correspondent, Teresa Poole, Business Correspondent, Rodney Lord, John Ballantine, David Mayne, Lawrence Lever, Richard B. Vintner, Matthew May, Alan Hamilton, Martin Fletcher, Political Reporter, Diana Geddes, David Guest, John Percival, Rex Bellamy, Tennis Correspondent, John Hennessy, Norman de Mesquita, Suzy Menkes, Roddy MacKenzie, Gavin Bell, E. A. Ash, Mark Davis, Terence Bendixson, David Cross, George Brock, Robert Kirley, Professor J. C. Levy, Harry Golombek Chess Correspondent, Eddie Coulter, Sydney Friskin, Nicholas Harling, David Smith, Economics Correspondent, Norman Gash, Ian Brown, Philip Webster, Chief Political Correspondent, Nicholas Wood Political Reporter, Christopher Dunn, William Holmes, Peter Davalle, John Russell Taylor, Steve Bates, Beryl Dixon, Jill Sherman, Craig Seton, Richard Owen, PHS, Barry Pickthall, Roger Boyes, Rory Johnston, David Sapsted, Richard Bassett, Sheila Gunn Political Staff, Frank Longford, Director, Brian Beel, Keith MacKlin, Diane Hill, Joanna MacGregor, David Hands Rugby Correspondent, Eddie Johnson, Geof Wheelwright, Jack Levy Director, Christopher Thomas, Jonathan Miller Media Correspondent, Frank Brown, George Ace, Ian Smith, David Wareing, Christopher Walker, Clive White, Paul Newman, Robert Grieves, Peter Dear and Peter Davalle, Stephen Pettitt, Magnus Pyke, John Woodcock, Cricket Correspondent, Miles Kingston, Bailey Morris, Nicholas Wood, Political Reporter, Jack Beal, Richard Evans and Michael Evans, Richard Lander, Chris Moore, St Moritz, Philip Jacobson, David Hands, Rugby Correspondent, Michael Coleman, Colin McQuillan, Richard Wigg,
... the instincts remain Military euphoria in Chad over Fada slaughter Fiat deal and papal visit top Jaruzelski' ...
1987 - Gale Group | TDA
Yiyuan Li, Zhengpeng Li, Yan Zhang, Guanzhou Zhou, Rongrong Ren, Huijun Zhao, Nana Zhang, Jianfeng Li, Lihua Peng, Yunsheng Yang,
... The key virulence factor of F.nucleatum is FadA adhesin for binding and invading of the host' ... we detected fecal F.nucleatum and virulence gene fadA in patients with ulcerative colitis(UC) and evaluated ... nucleatum (based on 16s rRNA) and virulence gene fadA. The detection rate of 16s rRNA based PCR ... P < 0.01). Moreover, 19 samples were detected fadA positive from 39 F.nucleatum positive samples of ... P < 0.05). There were 3 samples detected fadA positive from 14 F.nucleatum positive samples of ... P > 0.05). For both F.nucleatum and fadA gene positive patients, there were no statistical significances ...
Tópico(s): Microscopic Colitis
2021 - Elsevier BV | Microbial Pathogenesis
Sandra Lobo, Galina Florova, Kevin A. Reynolds,
... structure for the native enzyme. The corresponding gene (fadA) was cloned and sequenced and shown to encode ... acid sequence homology to type II thiolases. The fadA was expressed in Escherichia coli, and the resulting recombinant FadA enzyme purified by metal chelate chromatography was shown ... Kinetic studies revealed that in an ACT assay FadA had a substrate specificity for a two-carbon ... 9 +/- 1.8 microM). A Cys92Ser mutant of FadA possessed virtually unchanged K(m) values for acetoacetyl- ... mutant, demonstrating that both activities are associated with FadA and likely involve formation of the same covalent ...
Tópico(s): Enzyme Structure and Function
2001 - American Chemical Society | Biochemistry
Kunlong Yang, Qingru Geng, Yue Luo, Rui Xie, Tongzheng Sun, Zhen Wang, Ling Qin, Wei Zhao, Man Liu, Yongxin Li, Jun Tian,
... ROS). Transcriptome analysis indicated that the Gα protein FadA was significantly induced by PAE. Functional characterization of FadA showed it is important for asexual development and ... by regulation of cAMP‐PKA signalling. The Δ fadA mutant was more sensitive to PAE, while Δ ... A . flavus . Further RNA‐sequence analysis showed that fadA was important for expression of genes involved in ... flow cytometry and fluorescence microscopy demonstrated that Δ fadA accumulated more concentration of ROS in cells, and ...
Tópico(s): Mycotoxins in Agriculture and Food
2022 - Wiley | Environmental Microbiology
... the genes encoding these two subunits, fadB and fadA, has been determined. The direction of transcription was from fadB to fadA rather than from fadA to fadB, as suggested previously (S. K. Spratt ... an operon. The peptides encoded by fadB and fadA were 729 amino acids and 387 amino acids, ... 876 Da, respectively. Recently, the sequence of the fadA gene was published in a separate report (Yang ... this work, most of the DNA sequence for fadA was confirmed, and 10 errors were corrected. Three ... changes predicted in the carboxy terminus of the fadA-encoded peptide. By comparison to other peptide sequences, ...
Tópico(s): Enzyme Structure and Function
1990 - American Society for Microbiology | Journal of Bacteriology
Ping Liu, Yi Liu, Jianning Wang, Yang Guo, Yujie Zhang, Shuiqing Xiao,
... gingival inflammation under orthodontic appliance. A novel adhesin, FadA, which is unique to oral Fusobacteria, is required ... prevalence of F. nucleatum and its virulence factor FadA adhesion gene (fadA) in 169 subgingival biofilm samples from 55 cases ... via PCR. The correlations between the F. nucleatum/fadA and gingivitis index(GI)was also analyzed. The detection rate of F. nucleatum/fadA in periodontitis group and non-orthodontic gingivitis group ... was observed between the prevalence of F. nucleatum/fadA and GI. F. nucleatum carrying fadA may be ...
Tópico(s): Otolaryngology and Infectious Diseases
2014 - Public Library of Science | PLoS ONE
Mara Roxana Rubinstein, Xiaowei Wang, Wendy Liu, Yujun Hao, Guifang Cai, Yiping W. Han,
... stimulate growth of CRC cells through its unique FadA adhesin. FadA binds to E-cadherin, activates β-catenin signaling, ... differentially regulates the inflammatory and oncogenic responses. The FadA-binding site on E-cadherin is mapped to ... derived from this region of E-cadherin abolishes FadA-induced CRC cell growth and oncogenic and inflammatory responses. The fadA gene levels in the colon tissue from patients ... times higher compared to normal individuals. The increased FadA expression in CRC correlates with increased expression of ...
Tópico(s): Clostridium difficile and Clostridium perfringens research
2013 - Cell Press | Cell Host & Microbe
... However, the impact of Navvab Safavi and the Fada'ian-e Eslam on shaping a distinctly populist- ... Navvab Safavi (1924-55) was the founder of Fada'ian-e Eslam, a militant, fundamentalist Islamic organization ... Navvab Safavi and the other leaders of the Fada'ian-e Eslam were executed. Fada'ian-e Islam's principal objective was to ... Navvab Safavi, in his Barnameh-ye Enqelabi-ye Fada'ian-Eslam (1950) and in a series of ... Mo'talefeh Eslami) had some background in the Fada'ian-e Eslam. But more important, Navvab Safavi ...
Tópico(s): Religion and Society Interactions
1997 - Taylor & Francis | Middle Eastern Studies
Jae‐Hyuk Yu, Stefan Rosén, Thomas H. Adams,
... We showed previously that two genes, flbA and fadA, have a major role in determining the balance ... ST) production by the filamentous fungus Aspergillus nidulans. fadA encodes the α subunit for a heterotrimeric G-protein, and continuous activation of FadA blocks sporulation and ST production while stimulating growth. ... G-protein signaling (RGS) domain protein that antagonizes FadA-mediated signaling to allow development. To better understand FlbA function and other aspects of FadA-mediated growth control, we have isolated and characterized ...
Tópico(s): Microbial Natural Products and Biosynthesis
1999 - Oxford University Press | Genetics
Masoud Dadashi, Bahareh Hajikhani, Ebrahim Faghihloo, Parviz Owlia, Somayeh Yaslianifard, Mehdi Goudarzi, Mohammad Javad Nasiri, Fatemeh Fallah,
... men and women worldwide. Fusobacterium nucleatum adhesin A (FadA) has an important potential factor in the development ... was to evaluate the proliferative effect of recombinant FadA on SW480 colorectal cancer cell line.The recombinant pET21(b)-fadA plasmid was synthesized and transformed into competent E. ... the next step, induction and expression of recombinant FadA were carried out in E. coli BL21 (DE3) ... and western blotting. The proliferative effect of purified FadA on SW480 CRC cell line was evaluated using ...
Tópico(s): Pancreatic and Hepatic Oncology Research
2020 - Bentham Science Publishers | Infectious Disorders - Drug Targets
Akihiko Ikegami, Peter Chung, Yiping W. Han,
... studies identified a novel adhesin from F. nucleatum , FadA, as being involved in the attachment and invasion of host cells. The fadA deletion mutant F. nucleatum 12230 US1 was defective ... morphology and growth rate. In this study, a fadA -complementing clone, F. nucleatum 12230 USF81, was constructed. The expression of FadA on USF81 was confirmed by Western blotting and ... compared to the wild type and USF81. Thus, FadA plays an important role in F. nucleatum colonization ... represent the first complementation studies for F. nucleatum . FadA may be a therapeutic target for preventing F. ...
Tópico(s): Gut microbiota and health
2009 - American Society for Microbiology | Infection and Immunity
ABSTRACT The Stac Fada Member, which forms part of the Stoer Group, contains the only definitive evidence of volcanic activity within the thick ... sandy mudstone units are recognised in the Stac Fada. An irregular erosional contact at the base of the main Stac Fada unit truncates two thinner layers of similar volcanic- ... intrusions. Directional sedimentary structures associated with the Stac Fada mass flows, and the distribution and thickness of ... sources. Geochemical evidence suggests that the thick Stac Fada unit at the Bay of Stoer and comparable ...
Tópico(s): Geological and Geochemical Analysis
2002 - Cambridge University Press | Transactions of the Royal Society of Edinburgh Earth Sciences
Yiping W. Han, Akihiko Ikegami, Chythanya Rajanna, Hameem I. Kawsar, Yun Zhou, Mei Li, Hakimuddin T. Sojar, Robert J. Genco, Howard K. Kuramitsu, Cheri X. Deng,
... F. nucleatum. In this study, a novel adhesin, FadA (Fusobacterium adhesin A), was demonstrated to bind to ... surface proteins of the oral mucosal KB cells. FadA is composed of 129 amino acid (aa) residues, ... Fusobacterium russii, and Fusobacterium ulcerans. In addition to FadA, F. nucleatum ATCC 25586 and ATCC 49256 also ... FN1529 and FNV2159, each sharing 31% identity with FadA. A double-crossover fadA deletion mutant, F. nucleatum 12230-US1, was constructed ... to that of the wild type, indicating that FadA plays an important role in fusobacterial colonization in ...
Tópico(s): Oral Health Pathology and Treatment
2005 - American Society for Microbiology | Journal of Bacteriology
Ji-eun Shin, Sang-A Kho, Yun Sik Choi, Yong Cheol Kim, In‐Chul Rhyu, Youngnim Choi,
... characterized the antibody and T cell responses to FadA and Td92, adhesins from Fusobacterium nucleatum, an oral ... by IgA and then IgG4. The levels of FadA-specific salivary IgA (sIgA) were higher than Td92-specific sIgA and the FadA-specific IgA levels observed in plasma. However, the ... the individuals did not affect the levels of FadA- or Td92-specific antibody. Even healthy individuals contained FadA- and Td92-specific CD4+ T cells, as determined ... with CP tended to possess increased numbers of FadA- and Td92-specific CD4+ T cells but reduced ...
Tópico(s): Oral Health Pathology and Treatment
2013 - Public Library of Science | PLoS ONE
Guo Pin, Zibin Tian, Xinjuan Kong, Lin Yang, Xinzhi Shan, Bingzi Dong, Xueli Ding, Xue Jing, Chen Jiang, Na Jiang, Yanan Yu,
... time/day, i.g., 12 weeks), saline, or FadA knockout (FadA−/−) Fusobacterium nucleatum . The number, size, and weight of ... was determined by RT-qPCR. Protein expression of FadA, E-cadherin, β-catenin, and chk2 were determined ... in the S phase of the cell cycle. FadA−/− reduced tumor number, size, and burden in vivo. FadA−/− also reduced DNA damage, cell proliferation, expression of ... DNA damage and cell growth in CRC through FadA-dependent activation of the E-cadherin/β-catenin ...
Tópico(s): Cancer Cells and Metastasis
2020 - BioMed Central | Journal of Experimental & Clinical Cancer Research
... Assessment, and Clinical Practice Ronni Chernoff PhD, RD, FADA, Corresponding Author Ronni Chernoff PhD, RD, FADA [email protected] Geriatric Research Education and Clinical Center, ... RockCorrespondence and reprint requests: Ronni Chernoff, PhD, RD, FADA, GRECC, (182) CAVHS, 4300 W 7th St, Little ... papers by this author Ronni Chernoff PhD, RD, FADA, Corresponding Author Ronni Chernoff PhD, RD, FADA [email protected] Geriatric Research Education and Clinical Center, ... RockCorrespondence and reprint requests: Ronni Chernoff, PhD, RD, FADA, GRECC, (182) CAVHS, 4300 W 7th St, Little ...
Tópico(s): Nutrition and Health in Aging
2003 - Wiley | Nutrition in Clinical Practice
Stanley Nithianantham, Ming‐Hua Xu, Mitsunori Yamada, Akihiko Ikegami, Menachem Shoham, Yiping W. Han,
... a novel protein oligomerization motif identified in the FadA adhesin from the Gram-negative bacterium Fusobacterium nucleatum. ... angstroms crystal structure of the secreted form of FadA (mFadA) reveals two antiparallel alpha-helices connected by ... intermolecular role in the structure and function of FadA. First, they comprise the main association between the ... elongated polymers. This leucine-mediated filamentous assembly of FadA molecules constitutes a novel structural motif termed the " ... chain." The essential role of these residues in FadA is corroborated by mutagenesis of selected leucine residues, ...
Tópico(s): Streptococcal Infections and Treatments
2008 - Elsevier BV | Journal of Biological Chemistry
Danielle Arsenault, Megan Brenn, Sendia Kim, Kathleen M. Gura, Charlene Compher, Edwin Simpser, Mark Puder,
... by this authorCharlene Compher PhD, RD, CNSC, LDN, FADA, Corresponding Author Charlene Compher PhD, RD, CNSC, LDN, FADA compherc@nursing.upenn.edu Charlene Compher, PhD, RD, CNSC, LDN, FADA, University of Pennsylvania School of Nursing, Claire M. ... by this authorCharlene Compher PhD, RD, CNSC, LDN, FADA, Corresponding Author Charlene Compher PhD, RD, CNSC, LDN, FADA compherc@nursing.upenn.edu Charlene Compher, PhD, RD, CNSC, LDN, FADA, University of Pennsylvania School of Nursing, Claire M. ...
Tópico(s): Metabolism and Genetic Disorders
2011 - Wiley | Journal of Parenteral and Enteral Nutrition
... Agreement on Defining Malnutrition Annalynn Skipper PhD, RD, FADA, Corresponding Author Annalynn Skipper PhD, RD, FADA Annalynn_Skipper@comcast.net Annalynn Skipper & Associates, Oak Park, IllinoisAnnalynn Skipper, PhD, RD, FADA, Annalynn Skipper & Associates, PO Box 45, Oak Park, ... papers by this author Annalynn Skipper PhD, RD, FADA, Corresponding Author Annalynn Skipper PhD, RD, FADA Annalynn_Skipper@comcast.net Annalynn Skipper & Associates, Oak Park, IllinoisAnnalynn Skipper, PhD, RD, FADA, Annalynn Skipper & Associates, PO Box 45, Oak Park, ...
Tópico(s): Dietetics, Nutrition, and Education
2012 - Wiley | Journal of Parenteral and Enteral Nutrition
Charlene Compher, Carolyn Spencer, Bruce Kinosian,
... in Surgical Patients Charlene W. Compher PhD, RD, FADA, CNSD, Corresponding Author Charlene W. Compher PhD, RD, FADA, CNSD compherc@uphs.upenn.edu Penn Nursing and ... Support Service, andCorrespondence: Charlene W. Compher, PhD, RD, FADA, CNSD, 2114 Appletree St, Philadelphia, PA 19103-1336. ... by this author Charlene W. Compher PhD, RD, FADA, CNSD, Corresponding Author Charlene W. Compher PhD, RD, FADA, CNSD compherc@uphs.upenn.edu Penn Nursing and ... Support Service, andCorrespondence: Charlene W. Compher, PhD, RD, FADA, CNSD, 2114 Appletree St, Philadelphia, PA 19103-1336. ...
Tópico(s): Enhanced Recovery After Surgery
2005 - Wiley | Nutrition in Clinical Practice