Jocelyn Sabatier, Christophe Farges, Lamine Fadiga,
In order to solve some analysis or control problems for fractional order models, integer order approximations are often used. However, in many works, approximation error is not taken into account, leading to results that cannot be guaranteed for the initial fractional order model. The objective of the paper is thus to provide a new methodology that takes into account approximation error and leads to rewriting the fractional order model as an uncertain integer order model.
Tópico(s): Frequency Control in Power Systems
2015 - SAGE Publishing | Journal of Vibration and Control
Michele Bianchi, Stefano Carli, Michele Di Lauro, Mirko Prato, Mauro Murgia, Luciano Fadiga, Fabio Biscarini,
PEDOT:PSS capacitance is saturated at large volumes due to a change of ion penetration from a diffusive (at small volumes) to a non-diffusive regime.
Tópico(s): Neuroscience and Neural Engineering
2020 - Royal Society of Chemistry | Journal of Materials Chemistry C
Martina Giordani, Matteo Sensi, Marcello Berto, Michele Di Lauro, Carlo Augusto Bortolotti, Henrique L. Gomes, Michèle Zoli, Francesco Zerbetto, Luciano Fadiga, Fabio Biscarini,
Abstract Specific detection of dopamine (DA) is achieved with organic neuromorphic devices with no specific recognition function in an electrolyte solution. The response to voltage pulses consists of amplitude‐depressed current spiking mimicking the short‐term plasticity (STP) of synapses. An equivalent circuit hints that the STP timescale of the device arises from the capacitance and resistance of the poly(3,4‐ethylenedioxythiophene):polystyrenesulfonate (PEDOT:PSS) in series with the electrolyte ...
Tópico(s): Neuroscience and Neural Engineering
2020 - Wiley | Advanced Functional Materials
Michele Di Lauro, Anna De Salvo, Gioacchino Calandra Sebastianella, Michele Bianchi, Stefano Carli, Mauro Murgia, Luciano Fadiga, Fabio Biscarini,
Reversibly tunable short-term plasticity (STP) of the channel current in organic neuromorphic devices is demonstrated with a three-terminal architecture. Electrolyte-gated organic transistors—EGOTs—are driven with square voltage pulses at the drain electrodes, while the gate bias enables the modulation of the amplitude and characteristic time scale of the depressive STP spiking response up to 1 order of magnitude. The gate potential sets the baseline and the steady-state current, preluding multilevel ...
Tópico(s): Neuroscience and Neural Engineering
2020 - American Chemical Society | ACS Applied Electronic Materials
Stefano Carli, Michele Di Lauro, Michele Bianchi, Mauro Murgia, Anna De Salvo, Mirko Prato, Luciano Fadiga, Fabio Biscarini,
The water dispersion of the conductive polymer poly(3,4-ethylenedioxythiophene):poly(styrenesulfonic acid) (PEDOT:PSS) is one of the most used material precursors in organic electronics also thanks to its industrial production. There is a growing interest for conductive polymers that could be alternative surrogates or replace PEDOT:PSS in some applications. A recent study by our group compared electrodeposited PEDOT:Nafion vs PEDOT:PSS in the use for neural recordings. Here, we introduce an easy ...
Tópico(s): Perovskite Materials and Applications
2020 - American Chemical Society | ACS Applied Materials & Interfaces
Alessandro Roncone, Matej Hoffmann, Ugo Pattacini, Luciano Fadiga, Giorgio Metta,
This paper investigates a biologically motivated model of peripersonal space through its implementation on a humanoid robot. Guided by the present understanding of the neurophysiology of the fronto-parietal system, we developed a computational model inspired by the receptive fields of polymodal neurons identified, for example, in brain areas F4 and VIP. The experiments on the iCub humanoid robot show that the peripersonal space representation i) can be learned efficiently and in real-time via a ...
Tópico(s): Action Observation and Synchronization
2016 - Public Library of Science | PLoS ONE
Christophe Farges, Lamine Fadiga, Jocelyn Sabatier,
This paper addresses the problem of the H∞ control of commensurate Fractional Order Systems (FOS). Along the lines of recent work on H∞ norm computation for FOS, new extensions of the L∞ and H∞ bounded real lemmas to FOS are given after stating the differences between those two norms. An H∞ state feedback control method based on the corresponding bounded real lemma is then proposed. The efficiency of this method is evaluated on numerical examples.
Tópico(s): Stability and Control of Uncertain Systems
2013 - Elsevier BV | Mechatronics
Claudio Castellini, Leonardo Badino, Giorgio Metta, Giulio Sandini, Michele Tavella, Mirko Grimaldi, Luciano Fadiga,
We investigate the use of phonetic motor invariants (MIs), that is, recurring kinematic patterns of the human phonetic articulators, to improve automatic phoneme discrimination. Using a multi-subject database of synchronized speech and lips/tongue trajectories, we first identify MIs commonly associated with bilabial and dental consonants, and use them to simultaneously segment speech and motor signals. We then build a simple neural network-based regression schema (called Audio-Motor Map, AMM) mapping ...
Tópico(s): Speech Recognition and Synthesis
2011 - Public Library of Science | PLoS ONE
Irene Rembado, Elisa Castagnola, Luca Turella, Tamara Ius, Riccardo Budai, Alberto Ansaldo, Gian Nicola Angotzi, Francesco De Bertoldi, Davide Ricci, Miran Škrap, Luciano Fadiga,
High-density surface microelectrodes for electrocorticography (ECoG) have become more common in recent years for recording electrical signals from the cortex. With an acceptable invasiveness/signal fidelity trade-off and high spatial resolution, micro-ECoG is a promising tool to resolve fine task-related spatial-temporal dynamics. However, volume conduction - not a negligible phenomenon - is likely to frustrate efforts to obtain reliable and resolved signals from a sub-millimeter electrode array. To ...
Tópico(s): Blind Source Separation Techniques
2016 - World Scientific | International Journal of Neural Systems
Elisa Castagnola, Alberto Ansaldo, Emma Maggiolini, Tamara Ius, Miran Škrap, Davide Ricci, Luciano Fadiga,
Finding the most appropriate technology for building electrodes to be used for long term implants in humans is a challenging issue. What are the most appropriate technologies? How could one achieve robustness, stability, compatibility, efficacy, and versatility, for both recording and stimulation? There are no easy answers to these questions as even the most fundamental and apparently obvious factors to be taken into account, such as the necessary mechanical, electrical and biological properties, ...
Tópico(s): Conducting polymers and applications
2014 - Frontiers Media | Frontiers in Neuroengineering
Elisa Castagnola, Alberto Ansaldo, Emma Maggiolini, Gian Nicola Angotzi, Miran Škrap, Davide Ricci, Luciano Fadiga,
The ongoing interest in densely packed miniaturized electrode arrays for high-resolution epicortical recordings has induced many researchers to explore the use of nanomaterial coatings to reduce electrode impedance while increasing signal-to-noise ratio and charge injection capability. Although these materials are very effective, their use in clinical practice is strongly inhibited by concerns about the potential risks derived from the use of nanomaterials in direct contact with the human brain. ...
Tópico(s): Conducting polymers and applications
2013 - American Chemical Society | ACS Nano
Noah Goshi, Elisa Castagnola, Maria Vomero, Calogero Gueli, Claudia Cea, Elena Zucchini, David A. Bjånes, Emma Maggiolini, Chet T. Moritz, Sam Kassegne, Davide Ricci, Luciano Fadiga,
Abstract We report on a novel technology for microfabricating 3D origami-styled micro electro-mechanical systems (MEMS) structures with glassy carbon (GC) features and a supporting polymer substrate. GC MEMS devices that open to form 3D microstructures are microfabricated from GC patterns that are made through pyrolysis of polymer precursors on high-temperature resisting substrates like silicon or quartz and then transferring the patterned devices to a flexible substrate like polyimide followed by ...
Tópico(s): Advanced Sensor and Energy Harvesting Materials
2018 - IOP Publishing | Journal of Micromechanics and Microengineering
Stefano Carli, Giulia Fioravanti, Andrea Armirotti, Francesca Ciarpella, Mirko Prato, Giuliana Ottonello, Marco Salerno, Alice Scarpellini, Daniela Perrone, Elena Marchesi, Davide Ricci, Luciano Fadiga,
Abstract Localized drug delivery represents one of the most challenging uses of systems based on conductive polymer films. Typically, anionic drugs are incorporated within conductive polymers through electrostatic interaction with the positively charged polymer. Following this approach, the synthetic glucocorticoid dexamethasone phosphate is often delivered from neural probes to reduce the inflammation of the surrounding tissue. In light of the recent literature on the neuroprotective and anti‐inflammatory ...
Tópico(s): Electrochemical sensors and biosensors
2018 - Wiley | Chemistry - A European Journal
Sara De Faveri, Emma Maggiolini, Ermanno Miele, Francesco De Angelis, Fabrizia Cesca, Fabio Benfenati, Luciano Fadiga,
The use of implants that allow chronic electrical stimulation and recording in the brain of human patients is currently limited by a series of events that cause the deterioration over time of both the electrode surface and the surrounding tissue. The main reason of failure is the tissue inflammatory reaction that eventually causes neuronal loss and glial encapsulation, resulting in a progressive increase of the electrode-electrolyte impedance. Here, we describe a new method to create bio-inspired ...
Tópico(s): Advanced Memory and Neural Computing
2014 - Frontiers Media | Frontiers in Neuroengineering
Gytis Baranauskas, Emma Maggiolini, Alessandro Vato, Giannicola Angotzi, Andrea Bonfanti, Guido Zambra, Alessandro S. Spinelli, Luciano Fadiga,
It has been noted that the power spectrum of intracortical local field potential (LFP) often scales as 1/f(-2). It is thought that LFP mostly represents the spiking-related neuronal activity such as synaptic currents and spikes in the vicinity of the recording electrode, but no 1/f(2) scaling is detected in the spike power. Although tissue filtering or modulation of spiking activity by UP and DOWN states could account for the observed LFP scaling, there is no consensus as to how it arises. We addressed ...
Tópico(s): Advanced Memory and Neural Computing
2011 - American Physiological Society | Journal of Neurophysiology
The Journal of PhysiologyVolume 150, Issue 3 p. 633-655 ArticleFree Access Potential fields initiated during monosynaptic activation of frog motoneurones J. M. Brookhart, J. M. BrookhartSearch for more papers by this authorE. Fadiga, E. FadigaSearch for more papers by this author J. M. Brookhart, J. M. BrookhartSearch for more papers by this authorE. Fadiga, E. FadigaSearch for more papers by this author First published: 01 March 1960 https://doi.org/10.1113/jphysiol.1960.sp006409Citations: 78AboutPDF ...
Tópico(s): Advanced Memory and Neural Computing
1960 - Wiley | The Journal of Physiology
Stefano Carli, Michele Bianchi, Michele Di Lauro, Mirko Prato, Andréa Toma, Marco Leoncini, Anna De Salvo, Mauro Murgia, Luciano Fadiga, Fabio Biscarini,
Organic Electrochemical Transistors (OECTs) are suitable for developing ultra-sensitive bioelectronic sensors. In the organic electrochemical transistors architecture, the source-drain channel is made of a conductive polymer film either cast from a formulated dispersion or electrodeposited from a monomer solution. The commercial poly(3,4-ethylenedioxidethiophene)/poly(styrene sulfonate) (PEDOT:PSS) water dispersion is the workhorse of organic bioelectronics for its high conductance, low impact and ...
Tópico(s): Electrochemical sensors and biosensors
2022 - Frontiers Media | Frontiers in Materials
Maria Vomero, Maria Francisca Porto Cruz, Elena Zucchini, Francesca Ciarpella, Emanuela Delfino, Stefano Carli, Christian Boehler, Maria Asplund, Davide Ricci, Luciano Fadiga, Thomas Stieglitz,
Structural biocompatibility is a fundamental requirement for chronically stable bioelectronic devices. Newest neurotechnologies are increasingly focused on minimizing the foreign body response through the development of devices that match the mechanical properties of the implanted tissue and mimic its surface composition, often compromising on their robustness. In this study, an analytical approach is proposed to determine the threshold of conformability for polyimide-based electrocorticography ...
Tópico(s): Conducting polymers and applications
2020 - Elsevier BV | Biomaterials
Stefano Carli, Linda Lambertini, Elena Zucchini, Francesca Ciarpella, Alice Scarpellini, Mirko Prato, Elisa Castagnola, Luciano Fadiga, Davide Ricci,
Oxidized single walled carbon nanohorns (ox-SWCNH) were electrodeposited onto gold microelectrode arrays in conjunction with poly(3,4-ethylenedioxythiophene) (PEDOT) and polystirenesulfonate (PSS), and the properties of the new composite material for neural recording and stimulation were assessed. PEDOT/ox-SWCNH composites were compared with films prepared with one of the most notorious carbonaceous material in this field, the oxidized multi-walled Carbon Nanotubes (ox-MWCNT). The PEDOT/ox-SWCNH exhibited ...
Tópico(s): EEG and Brain-Computer Interfaces
2018 - Elsevier BV | Sensors and Actuators B Chemical
Elisa Castagnola, Emma Maggiolini, Luca Ceseracciu, Francesca Ciarpella, Elena Zucchini, Sara De Faveri, Luciano Fadiga, Davide Ricci,
The long-term reliability of neural interfaces and stability of high-quality recordings are still unsolved issues in neuroscience research. High surface area PEDOT-PSS-CNT composites are able to greatly improve the performance of recording and stimulation for traditional intracortical metal microelectrodes by decreasing their impedance and increasing their charge transfer capability. This enhancement significantly reduces the size of the implantable device though preserving excellent electrical ...
Tópico(s): Conducting polymers and applications
2016 - Frontiers Media | Frontiers in Neuroscience
Alberto Ansaldo, Elisa Castagnola, Emma Maggiolini, Luciano Fadiga, Davide Ricci,
We report for the first time how coatings made by directly growing carbon nanotubes (CNTs) on the tip of neural microelectrodes outperform others made by electrodeposited CNT composites. Not only do they reduce microelectrode impedance but they also are able to inject high currents without degradation and are stable in time. These results suggest that they are excellent candidates for chronic applications especially when both neural recording and stimulation have to be performed by the same microelectrode.
Tópico(s): EEG and Brain-Computer Interfaces
2011 - American Chemical Society | ACS Nano
Elisa Castagnola, Alberto Ansaldo, Luciano Fadiga, Davide Ricci,
Abstract Implantable electrodes are one of the most common tools in electrophysiology research, both for acute recording of intracortical signals and for chronical experiments. A stable low‐impedance electrode to tissue interface is fundamental to obtain reliable, long term recordings of the central nervous system activity. Commonly used metal electrodes do not fully meet such requirements, as their surface often degrades in time and they have high impedance. Nanostructured coatings, such as platinum ...
Tópico(s): EEG and Brain-Computer Interfaces
2010 - Wiley | physica status solidi (b)
Michele Bianchi, Anna De Salvo, Maria Asplund, Stefano Carli, Michele Di Lauro, Andreas Schulze‐Bonhage, Thomas Stieglitz, Luciano Fadiga, Fabio Biscarini,
Next-generation neural interfaces for bidirectional communication with the central nervous system aim to achieve the intimate integration with the neural tissue with minimal neuroinflammatory response, high spatio-temporal resolution, very high sensitivity, and readout stability. The design and manufacturing of devices for low power/low noise neural recording and safe and energy-efficient stimulation that are, at the same time, conformable to the brain, with matched mechanical properties and biocompatibility, ...
Tópico(s): Advanced Memory and Neural Computing
2022 - Wiley | Advanced Science
Alice Lunghi, Anna Mariano, Michele Bianchi, Nikita Bhupesh Dinger, Mauro Murgia, Eliana Rondanina, Andréa Toma, Pierpaolo Greco, Michele Di Lauro, Francesca Santoro, Luciano Fadiga, Fabio Biscarini,
Abstract Multi‐electrode arrays with 3D micropillars allow the recording of electrophysiological signals in vitro with higher precision and signal‐to‐noise ratio than planar arrays. This is the result of the tight interaction between the 3D electrode and the cell membrane. Most 3D electrodes are manufactured on rigid substrates and their integration on flexible substrates is largely unexplored. Here, a straightforward approach is presented for fabricating soft interfaces featuring 3D poly(3,4‐ethylenedioxythiophene)‐ ...
Tópico(s): Advanced Sensor and Energy Harvesting Materials
2022 - Wiley | Advanced Materials Interfaces
Stefano Carli, Michele Bianchi, Elena Zucchini, Michele Di Lauro, Mirko Prato, Mauro Murgia, Luciano Fadiga, Fabio Biscarini,
Microelectrode arrays are used for recording and stimulation in neurosciences both in vitro and in vivo. The electrodeposition of conductive polymers, such as poly(3,4-ethylene dioxythiophene) (PEDOT), is widely adopted to improve both the in vivo recording and the charge injection limit of metallic microelectrodes. The workhorse of conductive polymers in the neurosciences is PEDOT:PSS, where PSS represents polystyrene-sulfonate. In this paper, the counterion is the fluorinated polymer Nafion, so ...
Tópico(s): Advanced Memory and Neural Computing
2019 - Wiley | Advanced Healthcare Materials
Stefano Carli, Claudio Trapella, Andrea Armirotti, Anna Fantinati, Giuliana Ottonello, Alice Scarpellini, Mirko Prato, Luciano Fadiga, Davide Ricci,
Abstract PEDOT (Poly(3,4‐ethylenedioxythiophene)) is one of the most promising electrode materials for biomedical applications like neural recording and stimulation, thanks to its enhanced biocompatibility and electronic properties. Drug delivery by PEDOT is typically achieved by incorporating drugs as dopants during the electrodeposition procedure and a subsequent release can be promoted by applying a cathodic trigger that reduces PEDOT while enabling the drug to diffuse. This approach has several ...
Tópico(s): Advanced Sensor and Energy Harvesting Materials
2018 - Wiley | Chemistry - A European Journal
Michela Bassolino, M. Bove, Marco Jacono, Luciano Fadiga, Thierry Pozzo,
Tópico(s): Transcranial Magnetic Stimulation Studies
2012 - Elsevier BV | Neuroscience
Lamine Fadiga, Jocelyn Sabatier, Christophe Farges,
This paper addresses the problem of H∞ pseudo-state feedback stabilization of commensurate fractional order systems (FOS). Along the lines of recent work on H∞ norm computation for FOS, an extension of Bounded Real Lemma for FOS is proposed. This lemma is used to derive an H∞ state feedback control synthesis method. The efficiency of this method is evaluated on a fractional order academic system.
Tópico(s): Stability and Control of Uncertain Systems
2013 - Elsevier BV | IFAC Proceedings Volumes
Giovanna Cavazzini, Francesco Giacomel, Guido Ardizzon, Nicola Casari, Ettore Fadiga, Michele Pinelli, Alessio Suman, Francesco Montomoli,
Positive displacement (PD) machines are widely used in several applications such as in vapor and power generation systems. Nevertheless, their design is still based on standard approaches mainly driven by thermodynamic analysis and theoretical correlations. Geometrical details influence on the machine performance is often neglected. Because of this, PD machines hydraulic efficiency has not really been improved. The present work shows an innovative design strategy aimed at maximizing the machine efficiency ...
Tópico(s): Thermodynamic and Exergetic Analyses of Power and Cooling Systems
2020 - Elsevier BV | Energy
Nicola Casari, Ettore Fadiga, Michele Pinelli, Saverio Randi, Alessio Suman,
Micro-ORC systems are usually equipped with positive displacement machines such as expanders and pumps. The pumping system has to guarantee the mass flow rate and allows a pressure rise from the condensation to the evaporation pressure values. In addition, the pumping system supplies the organic fluid, characterized by pressure and temperature very close to the saturation. In this work, a CFD approach is developed to analyze from a novel point of view the behavior of the pumping system of a regenerative ...
Tópico(s): Refrigeration and Air Conditioning Technologies
2019 - Multidisciplinary Digital Publishing Institute | Energies