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Jornais Acesso aberto

Michael Stipe, Andrew Robson, luke kirwan, Phil Yates, John Coleman, Simon de Bruxelles and Helen Studd, Cath Urquhart, Sally Staples, Kate hilpern, Raymond Snoddy Media Editor, Andrew Eames, David Adams, John Kelly Vintage, Joanna Hunter, Sebastian Faulks, Richard Whitehead, Robert Cole, Helen Daniel, Neil Byrnem, Catherine Riley, Andrew Pierce, Tom Fort, Tom Rowland, James Moore, Nigel Colborn, D. G. Dabell, Maggie Alderson, Barbara Segall, Gary Duncan, Simon Barnes, Jane MacQuitty, David Booker, Bill Gates, Paul Hoggart, Richard Burge, Mark Souster, Emma Haughton, Jeremy myerson, Spiro James, Geneleve Douglas, Philip Howard, Nick Cave, ray main, Brian Duncan, Michael Binyon, James Bone, Fran LittleWood, Brian Pedley, Mike Wilkinson, Kate muir's, Jan Raath and Richard Beeston Diplomatic Editor, Shirley English, Philip Webster and Charles Bremner, Gabrielle Starkey, Jerermy Kingston, E. Jane Dickson, Sharon Linnard, GS, Canadian Crewe, Kevin Eason, Paul Nicolson, Sam Lister, Clare Stewart, Philip Glenister, Giles Coren, Andrew Norfolk, John Thicknesse, Antonia Senior, Ben Webster Transport Correspondent, Philippa MacLaran, Pat Gibson, David McVay, Julie Nightingale, Henry Goodman, Michael Heaney, Benet Steinberg, Jeff Dunne, Debra Craine, mariella frostrup, Linda Jobling, Victoria Segal, Jill Dupleix, Tim Reid, Mike Strutt, Richard Ford Home Correspondent, Jo Morris, Candida Crewe, Robin Young, Oliver Wright, Stephen Farrell, Alan Hamilton, Peter Millar, Rodney Milnes, Sam Litzinger, Mrs Esther Jacobson, Keith Tunstall, Philip Webster Political Editor and Paul Wilkinson, Philip Webster and Robin Young, Charles Bremner, Ian McCulloch, Martin Symington, Helen Rumbelow, Mark Souster and David Hands, Peter Barnard, Tim Teeman, Mark Court, Arthur Leathley City Correspondent, Caroline Merrell Banking Correspondent, Derwent May, Angela Jameson, Graham Weale, Ivan Hewett, JJ, Russell Kempson, Grainne Gilmore and Susan Emmett, Mary Gold, Daniel McGrory, Ed Potton, Oliver Kay, Richard Cork, Celia Skrine, Michael Dynes Africa Correspondent, Amber Cowan, Chen Zhen, Nick Ward, Mark Atherton, Matt Dickinson Football Correspondent, Jill Sherman Whitehall Editor, Liz Bird, anna selby, Geoffrey Wansell, Karen Early, Simon de Bruxelles, Allan Cousens, Geoffrey Dean, Rob Wright, Steven Cotton, Sarah Turner, Raymond Keene, Andy Shildrick, Peter Stothard and Dominic Kennedy, Matthew Pryor, Clive Mathieson, Matt Dickinson, Emily Sandys, Cheryl Taylor, Lucy Pinney, Paul Wilkinson, James Allcock, Greg Hurst Parliamentary Correspondent, Min Cooper, Peta Bee, Peter Bernard, Lisa Swanton, Eoin Colfer, Richard Owen, Anthony S. Kravitz, Damian Whitworth, Christopher Martin-Jenkins Chief Cricket Correspondent, Laurence Gerlis, Marcel Berlins, Roger Boyes, John Stern, Oliver August, Nick Hasell, Brian Fedley, Graham Searjeant Personal Investor, David Hands Rugby Correspondent, Michael J. Fox, R. Cross, Margarret Simons, Anne Ashworth, Dominic Kennedy, Micky Hammond, Dearbáil Jordan, James Doran, Giles Whittell, Sian Morgan, Barbara Oaff, Mel Webb, Mike Brewer, Paul McCann Media Correspondent, Sean Hillen, Matthew Parris, Beth Parker, Mark Hodkinson, Chris McGrath, Lea Paterson and Gary Duncan, Tim Wapshott, Glen Owen Education Correspondent, Brad Pitt, Alan Lee, P. H. Johnson, Walter Gammie, Jane Owen, james Collard, Ben MacIntyre, Alison Gibson, Richard Miles, Geoffrey Rowell, Simon Jenkins, William Cash, Martin Waller, Michael Horsnell, Chris Ayres, Danny Baker, Fran Littlewood, William Palmer, James Jackson, Benedict Nightingale, Paul Connolty, Jill Crawshaw, Jack Bailey, Tom Chesshyre, Adam Sherwin, SJ, Fiona Beckett, Robert Whymant, Olive Dauds, Sally Patten, Nick Baty, Channel Monroe, sheila keating, B. Whittingham, John Barclay, Beverly Kemp, Ian Altken, Sally Patten Retail Correspondent, Ellie Parker, Patience Wheatcroft, Christopher Irvine, Patrick Jenkin,

... 2001 Double top Ed Potton has new on Famke Janssen and Nicolas Cage Singles choice: Simian The Wisp ...

2001 - Gale Group | TDA

Artigo Acesso aberto Revisado por pares

Frans J. Mulder, Faisal Klufah, Famke M. E. Janssen, F. Farshadpour, Stefan M. Willems, Remco de Bree, Axel zur Hausen, Mari F.C.M. van den Hout, Bernd Kremer, Ernst‐Jan M. Speel,

Determine the presence and prognostic value of human papillomavirus (HPV), Epstein-Barr virus (EBV), Merkel cell polyomavirus (MCPyV), and cell cycle proteins in head and neck squamous cell carcinoma (HNSCC) of non-smokers and non-drinkers (NSND).Clinical characteristics and tumors of 119 NSND with HNSCC were retrospectively collected and analyzed on tissue microarrays. RNAscope in situ hybridization (ISH) was used to screen for the presence of HPV and MCPyV mRNA. Immunohistochemistry was performed for ...

Tópico(s): Tumors and Oncological Cases

2021 - Frontiers Media | Frontiers in Oncology

Jornais Acesso aberto

Andrew Robson, Phil Yates, Jon Ashworth, Raymond Snoddy Media Editor, Helen Studd, Robert Cole, Robert J. Leeming, Andrew Pierce, DJM, Lindsay Butler, David Brown, Zahid Hussain, Michael Hendrie Astronomy Correspondent, Sarah Potter, Richard Arch, Neil Inkley, Magnus Linklater, Peter Lansley, Mark Souster, Richard Hobson, Dominic Kennedy Crime Writer, Michael Evans Defence Editor, Nigel H. Harris, Philip Howard, Jennal Cox Fitness Editor, David Chater, Suna Erdem, Melissa Katsoulis, Nic Hopkins, Alexandra Frean Social Affairs Correspondent, Gabrielle Starkey, Carl Mortished, Barbara Ellen, Frances Stott, Roland Watson and Russell Jenkins, Kevin Eason, Nick Hasell Stock Markets, Geoff Brown, Joe Joseph, Mary Hampshire, Military Briefing General Wesley Clark, David Sharrock, Antonia Senior, Ben Webster Transport Correspondent, David McVay, Anne Spackman Property Editor, Tina Brown, Steve Keenan, Thrasy Petropoulos, Stewart Tendler Crime Correspondent, Anthony Browne, Dominic Walsh, James Doran Wall Street Correspondent, Debra Craine, Rory Watson, Norman Harris, Daniel Finkelstein, Ruth Gledhill Religion Correspondent, Dalya Alberge Arts Correspondent, Dan Sabbagh, Hussein Chalayan, Phoebe Greenwood, Nicholas Blanford, Oliver Wright Health Correspondent, David Colvin, Jenny MacArthur, Demetrios Matheou, Nick Wyke, Anatole Kaletsky, Phil Gordon, Sue Corbett, Valerie Elliott Consumer Editor, Helen Rumbelow, Stanley Siaughter, Matt Dickinson Chief Football Correspondent, David Charter, Nicholas Wapshott, Mark Court, Hugo Rifkind, Angela Jameson, Russell Kempson, Matthew Bell, Tony Halpin Education Editor, Suzy Jagger, Oliver Kay, Michael Dynes Africa Correspondent, Ross Clark, Tom Baldwin, Stephen Burgen, Mark Henderson Science Correspondent, David Lister and Russell Jenkins, Jill Sherman Whitehall Editor, Eli Perl, Lance Taylor, Rob Wright, Elaine Monaghan, John Nicholson, Geoffrey Dean, Neil Harman Tennis Correspondent, Raymond Keene, Matthew Pryor, Stephen Anderton The Times Gardener, Sean MacAulay, Philip Whiteley, Walter Gammle, Glen Owen Education Correspondent and Sam Lister, Christine Buckley Industrial Editor, Chris Partridge, Beryl Dixon, Peta Bee, Henry Richmond, Bronwen Maddox, Christopher Martin-Jenkins Chief Cricket Correspondent, Clem Cecil, Will Kenyon Finance & Accountancy Viewpoint, David Mattin, Peter Dixon, Sally Morris, T. E. Lawrence, Sarah Holmes, Adam Fresco, John Allison, Tim Garden, Nick Szczepanik, John Goodbody, Philip Webster Political Editor, Christopher Walker, J. Wheatley Price, Mel Webb, Des Dearlove, Ian Johns, Guy Liardet, Chris McGrath, Nicholas Hinde, Russell Jenkins, Ingrid Mansell, John Shaw, Alan Lee, Robert Tait, Matthew Pryor and Gary Jacob, Mark Court Health Industries Correspondent, Peter Riddell, Ben MacIntyre, Lea Paterson Economics Editor, Jeremy Hart, Nigel Massen, Tony Dawe, Matt Dickinson and Oliver Kay, Michael Dynes and Carl Mortished, Richard Miles, Rosemary Bennett and Tom Baldwin, Gary Duncan Economics Correspondent, Catherine Philp, Martin Waller, Alan Hamilton and Christine Buckley, Carl Mortished International Business Editor, Mark Baldwin, Laura Peek, Nigel Hawkes Health Editor, Sarah Butler, Benedict Nightingale, Jill Parkin, Roland Watson and Richard Beeston, Dr Thomas Stuttaford, Stephen Dalton, Ben Hoyle, Paul Connolly, Julian Ryall, Fred Emery, Tom Baldwin and Jill Sherman, Alan Lee Racing Correspondent, Royston Deitch, Greg Hurst and Tony Halpin, David Lister and Philip Webster, Brian Clarke Fishing Correspondent, Jan Raath, Jenny Davey, Colin McQuillan,

... Bondage Interview a Former Bond Girl who Survived, Famke Janssen, Of-Men 2, Tells All to Demetrios Matheou ...

2003 - Gale Group | TDA

Artigo Revisado por pares

Rayna Denison,

... McKellen and Anna Paquin through Halle Berry to Famke Janssen, X-Men's appeals ranged from the actorly ...

Tópico(s): Shakespeare, Adaptation, and Literary Criticism

2006 - Berghahn Books | Critical Survey

Jornais Acesso aberto

Jonathan Northcroft, Waldemar Januszczak, John Dugdale, Michael Prescott, Stephen Fry, I Newman, Robert Hewlson, Iain Morrison, Scott Athorne, Barbara Hall, Chris Stephen, Nigel Botherway, Dennis Barker The Guardian, Christopher Morgan Religious Affairs Correspondent, Donald MacGillivray, Tony Barrell, Don Aston, Kevin Coyne Managing Director, Andrew Warshaw, Fred Redwood, Harvey Nichols, Jon Swain, St John Wood, Nicholas Rufford, John Peter, Pam Barrett, Emma Moore, Amanda Ursell, Patrick Kearns, James Clough, John Jay, Alexandra Williams, Bernard Kaukas, Ivo Tennant, Sam Gilpin, Alistair Scott, David Smith, Kirstie Hamilton City Editor, John Goetz, Chris Dignan, Nick Pitt, Melanie Phillips, Louise Graham, Neil Wormald, Jane Bussmann, Andrew Sullivan, Clive Davis, Stephen Grey, Mary Wilson, Dylan Jones, Chris Goodwin, Sarah Gracle, Edward Platt, John Lawless, Tony Allen-Mills, Simon Wilde, Martin James, Robert Sandall, Eleanor Mills, Anthony Sattin, Steve Farrar, Robert Winnett, Alison Brace, Phil Taylor, Irwin Stelzer, Tom English, Peter Wilson, Roger Anderson, Marian Phillips, David Dougill, Dr Kamal Ahuja, Zoe Brennan Westminister Correspondent, Isabella Tree, Jane Whiter, David Hewson, Tania Alexander, Harvey Porlock, William Dalrymple, Margaret Coles, Hugh Canning, Alasdair Reid, Margarette Driscoll, A Palmer, Jeremy Clarkson, Edward Porter, Stewart Lee, David Cairns, Louise Taylor, Martin Slipp, Robert Harris, Eric Simons, Shelly von Strunckel, John Scotson, Stan Arnaud, Cathy Scott-Clark, Robin Marlar, Graham Otway, Tony Blair, Nick Gardner, Donald Diamond, Tom Reid, Adam LeBor, Mike Laws, Paul Ham, Stuart Wavell, Paul Donovan, Professor Robert Edwards, Simon Mills, Zoë Heller, Paul Driver, Derek Clements, Boris Schapiro, Garth Pearce, Phillip Kingsley, Nick Newman, Nicholas Hellen, Maeve Sheehan, Steven Downes, Jane Peter, Matthew Gwyther, Nick Brown minister, Bridget Freer, Michael Prescott Chief Political Correspondent, Steve Farrar Science Correspondent, Kirstie Hamilton, Tom Shone, Mark Edwards, Sarah Gracie, Susan Clark, Valentino, Hugh McLlvanney, David Lawrenson, Brian Steele, Professor Ian Cooke, Andrew Motion, John Harlow Arts Correspondent, Dr C Lacey (Former Director), Jocelyn de Moubray The Independent, Spike Milligan, Raymond Keene, Cosmo Landesman, Andrew Roberts, Marie Colvin, Diana Wright, Michael Prescott Cheif Political Correspondent, P J O'Rourke, Helen Hawkins, Stephen Jones, Richard Evans, Nick Cain, Peta Bee, Michael Wright, Stephen Bevan, Ewan McGregor, Natalie Graham, Andrew Smith, Paul Nuki, Rachel Forder, Martin Searby, Claire Oldfield, Zoë Linkson, David Walsh, Caroline Gascoigne, Rasselas, Trevor Lewis, Jack Grimston, Cheryl Holmes Perfect, Peter Bowen-Simpkins, Dr Malcolm George, Christopher Goodwin, Paul Kavanagh, Josh Salzmann, Mark Prigg, Ralph Kanter, Roger Panting, R W Johnson, Roland White, Garth Alexander, William Rees-Mogg, Maurice Chittenden, Alex Fortune, Kevin Pratt, Andrew Lorenz Business Editor, Judith O'Reilly, Mark Franchetti, Jonathan Powell, Ray Hutton, Jon Ungoed-Thomas, Peter Watts, Susan Elkin, G H Davies, John P McCarthy, Michael Sheridan, L Levy, Neil Pearsons, John Harlow, Matthew Lynn, Godfrey Smith, Michael Hodges, Mandy Payne, John Waples, John McManus, A A Gill, Delia Smith, Matthew Campbell, Brian Glanville, John Carey, Tom Robbins, Cherry Norton Social Affairs Correspondent, David Sumner Smith, Judge Barrington Black, Robert Johnston, Stephen Pettitt, Cherry Norton, Jeremy Langmead, Rw Johnson, Andrew Lorenz, Naomi Caine, Adrian Levy, Liam Clarke, David Wickers, Mark Sanderson, Tom Rhodes, Mark Hodson, Nicholas Hellen Media Correspondent, Harold Brooks-Baker, Joe Lovejoy, Jonathan Futrell, Jane Willoughby, Rupert Steiner, Hugh Pearman, Dave Selby, David Parsley, David Grylls, David Smith Economics Editor, James Hughes Onslow, Anthony Howard, Francesca Cunningham, Carey Scott, Walter Ellis, Aubrey Schifreen, Meg Mathews, Joanna Simon, Sandy Gall, Simon Howard, Dan Pearson, Dominic Rushe, Kevin Lunn, Karen Robinson, Teresa Hunter,

... Shone Les Miserables Out of bondage Cover story Famke Janssen has graduated successfully from 007 films to 'proper' ...

1998 - Gale Group | Sunday Times HA GDA

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

Marjan Cosyns, Geert Mortier, Sandra Janssens, Famke Bogaert, Stephanie D’Hondt, John Van Borsel,

Several authors mentioned the occurrence of articulation problems in the neurofibromatosis type 1 (NF1) population. However, few studies have undertaken a detailed analysis of the articulation skills of NF1 patients, especially in schoolchildren and adults. Therefore, the aim of the present study was to examine in depth the articulation skills of NF1 schoolchildren and adults, both phonetically and phonologically. Speech samples were collected from 43 Flemish NF1 patients (14 children and 29 adults), ...

Tópico(s): Soft tissue tumor case studies

2011 - Elsevier BV | Journal of Communication Disorders

Jornais Acesso aberto

Andrew Robson, Andrey Magee Ireland Correspondent, Caroline Muspratt, Christina Hardyment, John Coleman, Sara Hudston, McPhilemy, Raymond Snoddy Media Editor, Stella Shamoon, Nick Nuttall Environment Correspondent, Richard Whitehead, Barry Forshaw, Catherine Riley, Andrew Pierce, Flona Beckett, Trevor M. Jones, James Moore, Isobel Wilson, Grace Bradberry, Jane MacQuitty, Simon Barnes, Andrew Morgan, David Bullock, Clive King, Salome Munuo, Roland Watson and Andrew Pierce, Paul Hoggart, Brian Ellis, Hugh T. Wilson, Philip Howard, Andrew Taylor, Rodney E. B. Atkinson, Chris H. Sheldrake, Chris Clayton, Alex Brodie, James Bone, Clive Davis, Alexandra Frean Social Affairs Correspondent, Richard Irving, Yvonne Thomas, Victor Laurert, Sharon Linnard, Richard Cleroux, Tony Patrick, Amon Cohen, Tim Reid and Shirley English, Robin Gill, Sam Lister, J. J., Giles Coren, John O'Leary Education Editor, Antonia Senior, Martin Fletcher, Maureen Waller, AC, John Clarke, Philip Webster and Tom Baldwin, Henry Harris, Steve Keenan, Melanie Tringham, David Charter Education Correspondent, Jane Dickinson, Dominic Walsh, Steve Bird, Robert Greenwood, Mike Ripley, Martin Davies, Alan Road, Eddie Izzard, Victoria Segal, Roger Watkins, Jill Dupleix, Ross Dunn, Carol Price, Ruth Gledhill Religion Correspondent, Dalya Alberge Arts Correspondent, Skye Edwards, Jo Morris, Stephen Farrell, Robin Young, Peter Millar, Alan Millard, Andy Stephens, T. P., Anatole Kaletsky, Gerry Hanson, Andy Chant, Helen Rumbelow Medical Reporter, DW, John Goodbody and Tim Reid, Roland Watson, M. P. James, David Hands, Charles Bremner, conrad tracy, Roy Denman, Tim Teeman, Mark Court, Edward Gorman, Patience Wheatcroft Business Editor, Nigella Lawson, Angela Jameson, Russell Kempson, Adam Sage and Richard Ford, Paula Hawkins, Emma Mahony, Nigel Williamson, Daniel McGrory, Oliver Kay, David Fingleton, Stephen Anderton, Amber Cowan, Sharon O'Connell, RW, Frank Dahlgaard, Kieran Fatconer, John Barton, Tom Baldwin, Sally Walter, Simon de Bruxelles, Rob Wright, Adam Jones, David Powell Athletics Correspondent, Adam Sage, Matthew Pryor, Clive Mathieson, Matt Dickinson, Cheryl Taylor, Peter Hall, Victoria Walker, V. S., Paul Wilkinson, Paul Wilkinson and Laura Peek, David Chappell, Jesse Crosse, Alan Ayckbourn, Min Cooper, Chris Ayres Media Business Correspondent, Oliver Holt, Richard Owen, James Moore and Nick Hasell, Helen Nugent, Damian Whitworth, D. D. Raphael, Adrian Muller, Ross Leckie, Erica Wagner, Marcel Berlins, Arthur Taylor, Nick Hasell, James Jones, Margaret Kinsman, Greta Krypczyk-Oddy, Allan Hall, Charles Bremner, Richard Owen and Damian Whitworth, Richard Holledge, Dalya Alberge, David Hands Rugby Correspondent, Martin Fletcher European Correspondent, Steve Jelbert, John Goodbody, Dominic Kennedy, James Doran, Philip Webster Political Editor, Sophie Ratcliffe, Jane Shilling, Sally Varlow, Alex O'Connell, Craig Lord, Mel Webb, David Lister and Chris Ayres, Mike Brewer, Steve keenan, Andrew Pierce and Simon de Bruxelles, Paul McCann Media Correspondent, Matthew Parris, Deborah King, Jennai Cox, Natasha Cooper, Mark Hodkinson, Chris McGrath, Tim Wapshott, Alan Lee, Jane Owen, Ben MacIntyre, Brian Clarke, Kate Ray, Alison Gibson, Richard Miles, John Naish, Anne Ashworth Personal Finance Editor, Graham Searjeant, Minty Clinch, Mark Henderson, Martin Waller, Chris Ayres, RCJ, Danny Baker, Fran Littlewood, Carl Mortished International Business Editor, Kathleen Wyatt, Russell Jenkins and James Doran, Benedict Nightingale, Misha Glenny, Stephen Dalton, Jill Crawshaw, David Powell, Bill Edgar, Tom Chesshyre, McDermid, Elizabeth Buchan, Christina Korting, Valerie Grove, Tom Baldwin Deputy Political Editor, SJ, Fiona Beckett, RM, Allan Hall, William Wallis, Roland Watson Chief Political Correspondent, Andy Enright, Luc Delafosse, Patience Wheatcroft, Barbara Peters, Janine di Giovanni, Melaine Tringham, Christopher Irvine, Lucy Cartyfe, Frances Fyfield, Royal China, Susan Emmett, Richard Allen,

... there life after BOnd? For single bright female Famke Janssen, it has only jut begun CV This weekend' ...

2000 - Gale Group | TDA

Artigo Acesso aberto Revisado por pares

Famke Aeffner, Basant Abdulrahman, Judy M. Hickman‐Davis, Paul M.L. Janssen, Amal O. Amer, David M. Bedwell, Eric J. Sorscher, Ian C. Davis,

Background. Seasonal and pandemic influenza are significant public health concerns. Influenza stimulates respiratory epithelial Cl− secretion via the cystic fibrosis transmembrane conductance regulator (CFTR). The purpose of this study was to determine the contribution of this effect to influenza pathogenesis in mice with reduced CFTR activity. Methods. C57BL/6-congenic mice heterozygous for the F508del CFTR mutation (HET) and wild-type (WT) controls were infected intranasally with 10 000 focus-forming ...

Tópico(s): Influenza Virus Research Studies

2013 - Oxford University Press | The Journal of Infectious Diseases

Revisão Revisado por pares

Famke L. Schneiders, Rik J. Scheper, B. Mary E. von Blomberg, Andrea M. Woltman, Harry L.A. Janssen, Alfons J.M. van den Eertwegh, Henk M.W. Verheul, Tanja D. de Gruijl, Hans van Vliet,

For over a century, research has sought ways to boost the immune system in order to eradicate tumors and viruses that exist after escaping immunosurveillance. For the treatment of cancer and hepatitis immunotherapeutic strategies have overall had limited clinical success. An urgent need exists therefore to introduce more effective therapeutic approaches. Invariant (i)NKT cells constitute a conserved T lymphocyte lineage with dominant immunoregulatory, antitumor and antiviral effector cell properties. ...

Tópico(s): Immunotherapy and Immune Responses

2010 - Elsevier BV | Clinical Immunology

Artigo Acesso aberto Revisado por pares

Famke Wildemeersch, Peggy Jacques, Philippe Carron, Xavier Janssens,

Background: Rheumatoid arthritis (RA) is a chronic and progressive autoimmune disease that frequently has a negative impact on work participation among patients. Even more, patients with RA are at greater risk to become work disabled, have a reduced work productivity (presenteeism) or increased sick leave (absenteeism) compared to the general population. This outcome can be related to the World Health Organization International Classification of Functioning, Disability and Health (the WHO ICF framework), that ...

Tópico(s): Rheumatoid Arthritis Research and Therapies

2019 - BMJ | Annals of the Rheumatic Diseases

Artigo Revisado por pares

Ian C. Davis, Famke Aeffner, Basant Abdulrahman, Judy M. Hickman‐Davis, Paul M.L. Janssen, Don Hayes, Amal O. Amer, David M. Bedwell, Eric J. Sorscher,

Influenza virus inhibits bronchoalveolar epithelial ENaC‐mediated Na + absorption and stimulates Cl − secretion via CFTR, resulting in significant impairment of alveolar fluid clearance (AFC). To determine the contribution of CFTR to influenza pathogenesis, adult C57BL/6‐congenic F508del CFTR‐heterozygous mice (HETs) and wild‐type (WT) littermate controls were mock‐infected intranasally with 50 μl virus diluent (0.1% FCS in PBS) or infected with 10,000 FFU/mouse influenza A/WSN/33 (H1N1). Infection‐induced ...

Tópico(s): Neonatal Respiratory Health Research

2013 - Wiley | The FASEB Journal