María Silva‐Gago, Annapaola Fedato, Timothy L. Hodgson, Marcos Terradillos Bernal, Rodrigo Alonso Alcalde, Emiliano Bruner,
Tools, which have a cognitive background rooted in our phylogenetic history, are essential for humans to interact with their environment. One of the characteristics of human beings is the coordination between the eyes and hands, which is associated with a skilled visuospatial system. Vision is the first input of an action that influences interaction with tools, and tools have affordances, known as behavioural possibilities, which indicate their possible uses and potentialities. The aim of the present ...
Tópico(s): Face Recognition and Perception
2021 - Springer Nature | Archaeological and Anthropological Sciences
María Silva‐Gago, Flora Ioannidou, Annapaola Fedato, Timothy L. Hodgson, Emiliano Bruner,
The study of lithic technology can provide information on human cultural evolution. This article aims to analyse visual behaviour associated with the exploration of ancient stone artefacts and how this relates to perceptual mechanisms in humans. In Experiment 1, we used eye tracking to record patterns of eye fixations while participants viewed images of stone tools, including examples of worked pebbles and handaxes. The results showed that the focus of gaze was directed more towards the upper regions ...
Tópico(s): Face Recognition and Perception
2021 - SAGE Publishing | Perception
Produção Nacional
Danilo Malmonge Barbosa Luciano, Bárbara Nívea Fedato, Nayane Maria Vieira, Vinícius Vigliazzi Peghinelli, Anderson Seiji Soares Fujimori, Milene Peron Rodrigues Losilla, Maria Grossi Machado, Natália Baraldi Cunha, Maria Angélica Martins Lourenço,
O estresse oxidativo e o principal mediador da cirrose alcoolica, tornando-se relevante o estudo sobre a suplementacao de alimentos com propriedades antioxidantes, como o Caruru. Deste modo, o objetivo foi avaliar o efeito hepatoprotetor do Caruru no desenvolvimento da cirrose hepatica alcoolica experimental. Foram avaliados 40 ratos machos Wistar divididos em 4 grupos: CO (controle); CC (controle + racao padrao acrescida de Caruru 300mg/kg); HE (hepatotoxico); HC (hepatotoxico + racao padrao acrescida ...
Tópico(s): Food Science and Nutritional Studies
2020 - Brazilian Journal of Development | Brazilian Journal of Development
Annapaola Fedato, María Silva‐Gago, Marcos Terradillos Bernal, Rodrigo Alonso Alcalde, Emiliano Bruner,
Lower Paleolithic stone tool features and shape have been studied in detail; traceology and experimental archaeology have provided us with a lot of information about possible tool use and functionality. The way modern humans use these tools has been used as a proxy for the study of early stone tool-makers' behavior, taking into account that our ancestors could have had similar manipulative capabilities to us. Less importance has been given to stone tool ergonomics, even if comfortable and ergonomic ...
Tópico(s): Pleistocene-Era Hominins and Archaeology
2020 - Springer Nature | Archaeological and Anthropological Sciences
Nína M. Saviolidis, G. Ólafsdóttir, Mariana Nicolau, Antonella Samoggia, Élise Huber, Laura Brimont, Matthew Gorton, David von Berlepsch, Hildigunnur Sigurdardottir, Margherita Del Prete, Cristina Fedato, Pierre‐Marie Aubert, Sigurður G. Bogason,
Transitioning agri-food systems towards increased sustainability and resilience requires that attention be paid to sustainable food consumption policies. Policy-making processes often require the engagement and acceptance of key stakeholders. This study analyses stakeholders’ solutions for creating sustainable agri-food systems, through interviews with a broad range of stakeholders including food value chain actors, non-governmental organizations, governmental institutions, research institutions ...
Tópico(s): Agriculture Sustainability and Environmental Impact
2020 - Multidisciplinary Digital Publishing Institute | Sustainability
Annapaola Fedato, María Silva‐Gago, Marcos Terradillos Bernal, Rodrigo Alonso Alcalde, Elena Martín Guerra, Emiliano Bruner,
Abstract Objectives Tool use requires integration among sensorial, biomechanical, and cognitive factors. Taking into account the importance of tool use in human evolution, changes associated with the genus Homo are to be expected in all these three aspects. Haptics is based on both tactile and proprioceptive feedbacks, and it is associated with emotional reactions. Previous analyses have suggested a difference between males and females, and during haptic exploration of different typologies of stone ...
Tópico(s): Motor Control and Adaptation
2019 - Wiley | American Journal of Human Biology
Annapaola Fedato, María Silva‐Gago, Marcos Terradillos Bernal, Rodrigo Alonso Alcalde, Elena Martín Guerra, Emiliano Bruner,
Abstract Objectives Hand coordination is a key feature in primate evolution at both behavioral and cognitive levels. Humans further improved their manual abilities, and their cognitive niche is deeply associated with hand‐tool relationships and technological capacity. A main cognitive change is thought to be related to the transition from Oldowan to Acheulean stone tool technology around 1.7 million years ago. In this survey, we test whether distinct Lower Paleolithic tools induce different electrophysiological ...
Tópico(s): Tactile and Sensory Interactions
2019 - Wiley | American Journal of Human Biology
Emiliano Bruner, Annapaola Fedato, María Silva‐Gago, Rodrigo Alonso Alcalde, Marcos Terradillos Bernal, María Ángeles Fernández-Durantes, Elena Martín Guerra,
Body cognition and lateralization can be investigated in fossils by integrating anatomical and functional aspects. Paleoneurology cannot provide strong evidence in this sense, because hemispheric asymmetries are shared in all extinct human species, and motor cortical areas are difficult to delineate in endocranial casts. However, paleoneurological analyses also suggest that modern humans and Neanderthals underwent an expansion of parietal regions crucial for visuospatial integration and eye–hand– ...
Tópico(s): Motor Control and Adaptation
2018 - Elsevier BV | Progress in brain research
Emiliano Bruner, Annapaola Fedato, María Silva‐Gago, Rodrigo Alonso Alcalde, Marcos Terradillos Bernal, María Ángeles Fernández-Durantes, Elena Martín Guerra,
Testing cognitive hypotheses in extinct species can be challenging, but it can be done through the integration of independent sources of information (e.g., anatomy, archaeology, neurobiology, psychology), and validated with quantitative and experimental approaches. The parietal cortex has undergone changes and specializations in humans, probably in regions involved in visuospatial integration. Visual imagery and hand-eye coordination are crucial for a species with a remarkable technological and symbolic ...
Tópico(s): Multisensory perception and integration
2018 - Springer Science+Business Media | Current topics in behavioral neurosciences
María Silva‐Gago, Annapaola Fedato, Joseba Ríos-Garaizar, Emiliano Bruner,
Humans have evolved a distinctive relationship with "objects" (tools and technology), which has strongly influenced their anatomical and cognitive capacities. The human hand is functionally specialized for manipulation and, in terms of cognition, tools are generally integrated into the body scheme when handled. Stone tools can supply information on the evolution of this cognitive reciprocal relationship. Despite the many studies on stone tool morphology, information on hand-tool system is scanty. ...
Tópico(s): Tactile and Sensory Interactions
2018 - Elsevier BV | Journal of Archaeological Science Reports
Manuel Zorzi, Helena Frayle, Martina Rizzi, Chiara Fedato, Massimo Rugge, MG Penon, A Bertazzo, Susanna Callegaro, Marcelo Ivo Campagnolo, Francesco Perna, Annarosa Del Mistro,
Objective To compare the results from an initial negative human papillomavirus ( HPV ) test with re‐screening after 3 years in women attending two HPV ‐based screening programmes. Design Population‐based cohort study. Setting Two cervical service screening programmes in Italy. Population Women aged 25–64 years invited to screening from April 2009 to October 2015. Methods Eligible women were invited to undergo an HPV test. Those with a negative HPV test went on to the next screening round 3 years later. ...
Tópico(s): Reproductive tract infections research
2017 - Wiley | BJOG An International Journal of Obstetrics & Gynaecology
Daniela Bernardi, Paolo Belli, Eva Benelli, Beniamino Brancato, Lauro Bucchi, Massimo Calabrese, Luca Alessandro Carbonaro, Francesca Caumo, Beatrice Cavallo-Marincola, Paola Clauser, Chiara Fedato, Alfonso Frigerio, Vania Galli, Livia Giordano, Paolo Giorgi Rossi, Paola Golinelli, D Morrone, Giovanna Mariscotti, Laura Martincich, Stefania Montemezzi, Carlo Naldoni, Adriana Paduos, Pietro Panizza, Federica Pediconi, Fiammetta Querci, Antonio Rizzo, Gianni Saguatti, Alberto Tagliafico, Rubina Manuela Trimboli, Marco Zappa, Chiara Zuiani, Francesco Sardanelli,
This position paper, issued by ICBR/SIRM and GISMa, summarizes the evidence on DBT and provides recommendations for its use. In the screening setting, DBT in adjunct to digital mammography (DM) increased detection rate by 0.5-2.7‰ and decreased false positives by 0.8-3.6% compared to DM alone in observational and double-testing experimental studies. The reduction in recall rate could be less prominent in those screening programs which already have low recall rates with DM. The increase in radiation ...
Tópico(s): Medical Imaging Techniques and Applications
2017 - Springer Science+Business Media | La radiologia medica
Francesca Caumo, Manuel Zorzi, Silvia Brunelli, Giovanna Romanucci, Rossella Rella, Loredana Cugola, Paola Bricolo, Chiara Fedato, Stefania Montemezzi, Nehmat Houssami,
Purpose To examine the outcomes of a breast cancer screening program based on digital breast tomosynthesis (DBT) plus synthesized two-dimensional (2D) mammography compared with those after full-field digital mammography (FFDM). Materials and Methods This prospective study included 16 666 asymptomatic women aged 50-69 years who were recruited in April 2015 through March 2016 for DBT plus synthetic 2D screening in the Verona screening program. A comparison cohort of women screened with FFDM (n = 14 423) ...
Tópico(s): Medical Imaging Techniques and Applications
2017 - Radiological Society of North America | Radiology
Manuel Zorzi, Cesare Hassan, Giulia Capodaglio, Chiara Fedato, A Montaguti, Anna Turrin, A Rosano, D Monetti, Carmen Stocco, Susanna Baracco, Francesca Russo, Alessandro Repici, Massimo Rugge,
The long-term performance of colorectal cancer (CRC) screening programmes based on a 2-year faecal immunochemical test (FIT) is still unclear.In a sample of 50 to 69-year-olds repeatedly screened with the FIT (OC-Hemodia latex agglutination test; cut-off: 20 µg haemoglobin/g faeces), we examined: (1) the FIT positivity rate, the CRC and advanced adenoma detection rate and the FIT's positive predictive value (PPV) for advanced neoplasia, at each round of screening and (2) the cumulative CRC and advanced ...
Tópico(s): Gastrointestinal disorders and treatments
2017 - BMJ | Gut
T Maggino, Rocco Sciarrone, Bruno Murer, Maria Rosa Dei Rossi, Chiara Fedato, Michela Maran, Melania Lorio, Marika Soldà, Fiorella Zago, Paolo Giorgi Rossi, Manuel Zorzi,
HPV DNA-based screening is more effective than a Pap test in preventing cervical cancer, but the test is less specific. New HPV tests have been proposed for primary screening. The HPV mRNA test showed a similar or slightly lower sensitivity than the HPV DNA tests but with a higher specificity. We report the results of an organised HPV mRNA-based screening pilot program in Venice, Italy. From October 2011 to May 2014, women aged 25–64 years were invited to undergo a HPV mRNA test (Aptima). Those testing ...
Tópico(s): Molecular Biology Techniques and Applications
2016 - Springer Nature | British Journal of Cancer
Guglielmo Ronco, Marco Zappa, Silvia Franceschi, Sara Tùnesi, Adele Caprioglio, Massimo Confortini, Annarosa Del Mistro, Francesca Carozzi, Nereo Segnan, Manuel Zorzi, Paolo Giorgi Rossi, Anna Gillio‐Tos, Pamela Giubilato, Luigi Pasquale, Gilda da Graça Luciano, E Polla, Paolo Dalla Palma, Chiara Fedato, Fiorella Zago, Ariel Leyva Pupo, I. Simoncello, Maria Gabriella Penon, Lauren Gallo, Annamaria Del Sole, Luisa Paterlini, Cinzia Campari, Anna Iossa, Alessandra Barca, Maria Concetta Tufi, Paola Bellardini, C Fortunato, Maria Carmela Minna, A. Macerola, Donatella Caraceni,
BackgroundWomen positive to human papillomavirus (HPV+) testing at cervical screening need triage, typically cytology and immediate colposcopy in case of atypical squamous cells of undetermined significance (ASCUS) or worse (ASCUS+) or, in cytology-normal HPV+ women, HPV test repeat after 1 year and colposcopy referral if still HPV+. Our hypothesis was that substantial variations in triage positivity and sensitivity may produce little variation in overall referral to colposcopy and on sensitivity of ...
Tópico(s): Global Cancer Incidence and Screening
2016 - Elsevier BV | European Journal of Cancer
Lauro Bucchi, Paolo Belli, Eva Benelli, Daniela Bernardi, Beniamino Brancato, Massimo Calabrese, Luca Alessandro Carbonaro, Francesca Caumo, Beatrice Cavallo-Marincola, Paola Clauser, Chiara Fedato, Alfonso Frigerio, Vania Galli, Livia Giordano, Paola Golinelli, Giovanna Mariscotti, Laura Martincich, Stefania Montemezzi, D Morrone, Carlo Naldoni, Adriana Paduos, Pietro Panizza, Federica Pediconi, Fiammetta Querci, Antonio Rizzo, Gianni Saguatti, Alberto Tagliafico, Rubina Manuela Trimboli, Chiara Zuiani, Francesco Sardanelli,
Women who were previously treated for breast cancer (BC) are an important particular subgroup of women at intermediate BC risk. Their breast follow-up should be planned taking in consideration a 1.0–1.5 % annual rate of loco-regional recurrences and new ipsilateral or contralateral BCs during 15–20 years, and be based on a regional/district invitation system. This activity should be carried out by a Department of Radiology integrating screening and diagnostics in the context of a Breast Unit. We recommend ...
Tópico(s): Breast Lesions and Carcinomas
2016 - Springer Science+Business Media | La radiologia medica
Anna Turrin, Manuel Zorzi, Paolo Giorgi Rossi, Carlo Senore, Cinzia Campari, Chiara Fedato, Carlo Naldoni, Emanuela Anghinoni, Giuliano Carrozzi, Priscilla Sassoli de Bianchi, Marco Zappa, Manuela Di Giacomo, Angelo Sigillito, Liliana Rizzo, Giovanna Luciano, Carlo Naldoni, Nora Coppola, Alessandra Barca, G. Paoli, L Bonelli, Liliana Cóppola, Lucia Di Furia, Giuseppe Cecere, Nereo Segnan, Antonio Fanolla, Silvano Piffer, Cinzia Germinario, Pierina Tanchis, Gabriella Dardanoni, Paola Mantellini, Mariadonata Giaimo, Gabriella Furfaro, Manuel Zorzi,
Colorectal cancer screening programmes in Italy invite 50–69-year-old residents for a faecal immunochemical test every two years, regardless of their citizenship. The 2013 National Survey on Italian colorectal cancer screening programmes compared immigrants born in low- or middle-income countries with subjects who were born in Italy, by collecting aggregated data on compliance, faecal immunochemical test results, compliance with colonoscopy, detected lesions and stage at diagnosis separately for ...
Tópico(s): Genetic factors in colorectal cancer
2015 - Elsevier BV | Preventive Medicine
Manuel Zorzi, Carlo Senore, Anna Turrin, Paola Mantellini, Carmen Beatriz Visioli, Carlo Naldoni, Priscilla Sassoli de Bianchi, Chiara Fedato, Emanuela Anghinoni, Marco Zappa, Cesare Hassan,
To assess the appropriateness of recommendations for endoscopic surveillance in organised colorectal cancer (CRC) screening programmes based on the faecal immunochemical test (FIT).74 Italian CRC screening programmes provided aggregated data on the recommendations given after FIT-positive colonoscopies in 2011 and 2013. Index colonoscopies were divided into negative/no adenoma and low- risk, intermediate-risk and high-risk adenomas. Postcolonoscopy recommendations included a return to screening (FIT ...
Tópico(s): Diverticular Disease and Complications
2015 - BMJ | Gut
Cinzia Campari, Chiara Fedato, Anna Iossa, Alessio Petrelli, Manuel Zorzi, Emanuela Anghinoni, Carla Bietta, Angela Brachini, Silvia Brezzi, Carla Cogo, Livia Giordano, Daniela Giorgi, Mauro Palazzi, Marco Petrella, Maria Rosa Schivardi, Carmen Beatriz Visioli, Paolo Giorgi Rossi,
Cervical cancer screening programmes in Italy actively invite all 25-64-year-old resident women for the Pap test every 3 years irrespective of their citizenship. Immigrant women come from countries where screening is absent or poorly implemented and the prevalence of human papillomavirus is often high. These women therefore have significant risk factors for cervical cancer. The Italian Group for Cervical Cancer Screening promoted a survey of all the screening programmes on the participation and ...
Tópico(s): Global Cancer Incidence and Screening
2015 - Lippincott Williams & Wilkins | European Journal of Cancer Prevention
Manuel Zorzi, Ugo Fedeli, Elena Schievano, Emanuela Bovo, Stefano Guzzinati, Susanna Baracco, Chiara Fedato, Mario Saugo, Angelo Paolo Dei Tos,
Objective Colorectal cancer (CRC) screening programmes based on the guaiac faecal occult blood test (gFOBT) reduce CRC-specific mortality. Several studies have shown higher sensitivity with the faecal immunochemical test (FIT) compared with gFOBT. We carried out an ecological study to evaluate the impact of FIT-based screening programmes on CRC mortality. Design In the Veneto Region (Italy), biennial FIT-based screening programmes that invited 50–69-year-old residents were introduced in different areas between ...
Tópico(s): Esophageal Cancer Research and Treatment
2014 - BMJ | Gut
Annarosa Del Mistro, Helena Frayle, António Ferro, Susanna Callegaro, Annamaria Del Sole, Anna Stomeo, Emanuela Cirillo, Chiara Fedato, Silvana Pagni, Luisa Barzon, Manuel Zorzi,
Objective Cervical cancer screening by human papillomavirus (HPV) testing requires the use of additional triage and follow-up analyses. We evaluated women’s compliance with and the performance of this strategy in a routine setting. Setting Five cervical service screening programmes in North-East Italy. Methods Eligible women aged 25-64 invited for a new screening episode underwent HPV testing for high risk types (hrHPV by Hybrid Capture 2) and cytology triage. Women with positive HPV and cytology ...
Tópico(s): Reproductive tract infections research
2014 - SAGE Publishing | Journal of Medical Screening
Produção Nacional
Edson Luis Maistro, Eduardo de Souza Marques, Rafael Palhano Fedato, Flora Tolentino, Chayene de Andrade Cezário da Silva, Marcela Stefanini Ferreira Tsuboy, Flávia Aparecida Resende, Eliana Aparecida Varanda,
AbstractCoumarins are naturally occurring compounds, widely distributed throughout the plant kingdom (Plantae), and possess important pharmacological properties, including inhibition of oxidative stress. In this context, newly synthesized coumarin compounds are being produced due to their potent antioxidant activities. Therefore, the aim of the present study was to determine the in vitro cytotoxic, mutagenic, and genotoxic effects of 6,7-dihydroxycoumarin (6,7-HC) and 4-methylesculetin (4-ME) using ...
Tópico(s): Genomics, phytochemicals, and oxidative stress
2014 - Taylor & Francis | Journal of Toxicology and Environmental Health
Manuel Zorzi, Annarosa Del Mistro, Angelo Farruggio, L de' Bartolomeis, Helena Frayle, Lorena Baboçi, A Bertazzo, Pier Luigi Cocco, Chiara Fedato, Maria Laura Gennaro, Natalina Marchi, MG Penon, Carla Cogo, António Ferro,
Objective To present the results of the first 2 years of a human papillomavirus ( HPV ) test‐based screening programme outside the research context. Design Population‐based cohort study. Setting A cervical service screening programme in I taly. Population Women aged 25–64 years invited to screening from A pril 2009 to April 2011. Methods Eligible women were invited to undergo an HPV test: those with a negative HPV test went on to the next screening episode; those with a positive HPV went on to triage ...
Tópico(s): Genital Health and Disease
2013 - Wiley | BJOG An International Journal of Obstetrics & Gynaecology
Produção Nacional
Revisado por pares
Rafael Palhano Fedato, Edson Luis Maistro,
ABSTRACT 4‐Methylesculetin (4‐ME) is a synthetic derivative of coumarin that displays a potent reactive oxygen species (ROS) scavenger and metal chelating agent and therefore has been produced to help reduce the risk of human disease. The main objective of this study was to investigate the in vivo genotoxicity of 4‐ME and initially to verify its potential antigenotoxicity on doxorubicin (DXR)‐induced DNA damage. Different doses of 4‐ME (500, 1000 and 2000 mg kg –1 body weight) were administered by gavage ...
Tópico(s): Carcinogens and Genotoxicity Assessment
2012 - Wiley | Journal of Applied Toxicology
Manuel Zorzi, Chiara Fedato, Grazia Grazzini, Flavio Stocco, Flavio Banovich, A. Bortoli, L. Cazzola, A Montaguti, T Moretto, Marco Zappa, Marcello Vettorazzi,
Although guaiac-based faecal occult blood test screening has been shown to be effective in reducing colorectal cancer (CRC) mortality, it has been criticised mostly for its low sensitivity. Italian CRC screening programmes are based on immunochemical tests (iFOBT). We collected and analysed the interval cancers (ICs) found by five screening programmes to estimate their sensitivity.ICs were identified in subjects who had a negative result in a screening examination from 2002 to 2007 (N=267,789); data ...
Tópico(s): Genetic factors in colorectal cancer
2010 - BMJ | Gut
Produção Nacional
Revisado por pares
Rafael Palhano Fedato, Juliana Delatim Simonato, Cláudia Bueno dos Reis Martinez, Silvia Helena Sofia,
Although gasoline is an important contaminant of aquatic ecosystems, information concerning the potential effects of this petroleum derivative on the DNA of aquatic biota is lacking. The present study aimed to evaluate the genotoxic and mutagenic effects of acute exposures (6, 24, and 96 h) to gasoline water-soluble fraction (GWSF), diluted to 5%, on the Asian clam Corbicula fluminea. The comet assay and the micronucleus (MN) test were performed on hemocytes and gill cells of C. fluminea. For the three ...
Tópico(s): Pharmaceutical and Antibiotic Environmental Impacts
2010 - Elsevier BV | Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Produção Nacional
Revisado por pares
Gisane Biacchi Gomes, Ana Denise Zazula, Leonardo Shigueoka, Rosangela Alquieri Fedato, Ana Beatriz Brenner Affonso da Costa, Luiz César Guarita-Souza, Cristina Pellegrino Baena, Márcia Olandoski, José Rocha Faria‐Neto,
Consumption of food products enriched with plant sterols and the use of ezetimibe reduce cholesterol absorption in the intestine and effectively reduce low-density lipoprotein (LDL) plasma levels. We evaluated the therapeutic effect of the ezetimibe+plant sterol association in patients with coronary artery disease still not reaching recommended lipid levels despite the use of statins. We performed a prospective open-label study with 41 patients with stable coronary disease and LDL >70 mg/dL. Patients ...
Tópico(s): Cancer, Lipids, and Metabolism
2017 - Mary Ann Liebert, Inc. | Journal of Medicinal Food
Manuel Zorzi, Susanna Baracco, Chiara Fedato,
In their recent paper, Grazzini and colleagues1 reported a decrease in the positivity of the immunochemical faecal occult blood test (iFOBT) for colorectal cancer screening during the summer period. Their results predict a higher rate of false-negative iFOBT results during the hot season. This effect is likely to be higher for patients with minor neoplastic lesions, where the haemoglobin concentration in faeces is usually lower2 than in patients with …
Tópico(s): Colorectal Cancer Screening and Detection
2010 - BMJ | Gut
E. Fedato, Mattia Baldini, Alberto Dalla Riva, David Fernando Mora Alvarez, A.K. Wiuff, János Hethey, Eduardo Cerrajero, Jose Miguel Estebaranz,
... GRIDSOL technology in Fuerteventura: A case study E. Fedato, Corresponding Author E. Fedato eli.fedato@gmail.com Technical University of Denmark, DTU Management ... SpainSearch for more papers by this author E. Fedato, Corresponding Author E. Fedato eli.fedato@gmail.com Technical University of Denmark, DTU Management ...
Tópico(s): Integrated Energy Systems Optimization
2019 - Institution of Engineering and Technology | The Journal of Engineering