Andrew Robson, Phil Yates, Christina Hardyment, Raymond Snoddy Media Editor, Jonathan Balcombe, Robert Cole, Matthew Syed, Catherine Riley, Andrew Pierce, Ian Nathan, Adam Sherwin Media Reporter, Sarah Potter, Peter Lansley, George Ball, Brendan Quinn, Cannock, Staffordshire, Mark Souster, Dr James Briggs, David Rhys Jones, P. F. Simpson, Ivo Tennant, T. Rattigan, Horbury, Michael Evans Defence Editor, Philip Howard, Hilary Finch, Jennal Cox Fitness Editor, David Chater, James Bone, B.M.Gray, Bryan Thwaites, Alexandra Frean Social Affairs Correspondent, Richard Hobson One-Day Cricket Correspondent, Elizabeth Judge, Gabrielle Starkey, Eleanor Stoneham, Jesse Devons, Neville Scott and Michael Austin, Sam Marlowe, Wendy Ide, Roger Maynard, Owen McNulty, Joe Joseph, Peter Brown, Antonia Senior, Ben Webster Transport Correspondent, Pat Gibson, David McVay, Jan Allen, Richard Rothwell, Anthony Browne, Alex O'Henley, Dominic Walsh, Peter Nicholls, James Doran Wall Street Correspondent, Jesse Green, Peter Watson, Philip Webster Political Editor and Tom Baldwin, James Hider and Philip Webster Political Editor, Lynn Sawyer, Dr James O'Berne, David Rudd, Dan Sabbagh, Dalya Alberge Arts Correspondent, Sally-Anne Tsangarides, Jill Dupleix, Nicholas Blanford, Alan Hamilton, Robin Young, Mike Crowley, Rosemary Bennett and David Charter, Jenny MacArthur, David Eimer, Anatole Kaletsky, Roland Watson, Angela Lamb, Phillip Webster Political Editor, Adam LeBor, Ian MacKinnon, Mark Browne, Stefanie Marsh, Greg Hurst, Bronwen Maddox Foreign Editor's Briefing, James Hider and Stephen Farrell, Nicholas Wapshott, Edward Gorman, Angela Jameson, Rupert Read, Russell Kempson, Timothy Jones, Lewes, East sussex, Oliver Kay, Michael J. Hendrie Astronomy Correspondent, Giles Smith Sport on Television, Roddy Urquhart, Tom Baldwin, Jill Sherman Whitehall Editor, Mark Henderson Science Correspondent, Antony Crookston, Waterlooville, Hampshire, Christopher Martin-Jenkins, Paul Oestreicher Chairman, Ann Treneman, Sean Macaulay, Geoffrey Dean, Raymond Keene, Leslie Felperin, Hugh Davies, Matthew Pryor, Richard Miles Investment Editor, Philip Whiteley, Richard Ford and Stewart Tendler, Christine Buckley Industrial Editor, Sean O'Neill, Andrew Drummond, Beryl Dixon, Jeremy Page, Chris Campling, Russell Hotten, Cathy Harris, Richard Owen, Christopher Martin-Jenkins Chief Cricket Correspondent, David Mattin, Peter Dixon, Nick Hasell, Saran Vine, Dalya Alberge, David Hands Rugby Correspondent, Owen Slot Chief Sports Reporter, Julian Muscat, Glen Owen, Adam Fresco, John Allison, Brian Turvey, Nick Szczepanik, John Goodbody, Christine Buckley Industry Editor, Ian Johns, Des Dearlove, Wendy Davies, Ottery St Mary, Devon, Consuelo Foley, J. P. Lloyd, Russell Jenkins, Glen Owen Education Correspondent, Alan Lee, Walter Gammie, Anthony Loyd, Peter Riddell, John Offord, Tony Dawe, David Williams, Gavin Reeve, Richard Beeston Diplomatic Editor, David Charter Chief Political Correspondent, Tom Hennigan, Mark Henderson, Catherine Philp, Michael Horsnell, Chris Ayres, Martin Waller, Carl Mortished International Business Editor, Cyril N. Cowley, Nigel Hawkes Health Editor, Sarah Butler, David Heather, Mark Baldwin, Ashling O'Connor, Daniel Rosenthal, Catherine Townsend, Stephen Dalton, Dr Thomas Stuttaford, Hugh Thompson, Ben Hoyle, Dr David Hearn, Bill Edgar, James Christopher, Alice Miles, Randy Cohen, Alan Lee Racing Correspondent, Owen Slot, Robbie Millen, Gaia Vince, Andrew Sheard, Jane Dean, Jan Raath, Jenny Davey, Edward Gorman Sailing Correspondent, Phill Gordon, Michael Meacher, Peter Klinger, Sam Lister Health Correspondent, Patience Wheatcroft, Christopher Irvine,
... acknowledgements or notices … Deaths Births Lives in Brief Federico Block Macias, airline executive, was born on February ...
2004 - Gale Group | TDA
Ivo Baroň, Federico Agliardi, Christian Ambrosi, Giovanni B. Crosta,
Abstract. Deep-seated slope failures are common features in the mountains of the Raca Unit, Magura Nappe of the Flysch Belt of Western Carpathians. Since they represent very complicated system, understanding of their evolution and triggers still remains unclear. We tried to provide a back-analysis of their development by using a finite difference code (FDM) of continua (Flac 4.0). We confirmed that such large mass movements could be triggered by water saturation of the bedrock in the three particular ...
Tópico(s): Climate change and permafrost
2005 - Copernicus Publications | Natural hazards and earth system sciences
Jon Ashworth, Cath Urquhart, Raymond Snoddy Media Editor, Graham Wistow, Stella Shamoon, Robert Cole, Portia Colwell, Andrew Pierce, James Moore, Grace Bradberry, Zoe Moore, Jane MacQuitty, Simon Barnes, Alexandra Frean Local Government Correspondent, John Morgan, David Angel, Paul Hoggart, Mark Souster, Richard Hobson, Ivo Tennant, Douglas Friedli, Birna Helgadottir, Philip Howard, ray main, Laird, Jeremy Kingston, James Bone, Helene Hayman, Clive Davis, Elizabeth Judge, Paul McCann and Tom Baldwin, Paul de Zylva, Gillian Harris Scotland Correspondent, Sharon Linnard, Anne Robinson, Dominic Bradbury, christopher Martin-Jenkins Chief Cricket Correspondent, Tony Patrick, Brian Milner, Clare Stewart, Andrew Norfolk, John O'Leary Education Editor, Viv Richards, John Thicknesse, Adam Hopkins, Antonia Senior, Gill Baron, Conal Urquhart, Pat Gibson, John O'Leary and Jack Malvern, Don Paterson, Paul Fitzpatrick, Valerie Elliott, Chandos Elletson, D. R., Steve Keenan, Stewart Tendler Crime Correspondent, Simon Morgan, Steve Bird, Jerome Boyd Maunsell, Christine Buckley Steve Bird and Tom Baldwin, Alix Ramsay Tennis Correspondent, Ruth Gledhill Religion Correspondent, Dalya Alberge Arts Correspondent, Jo Morris, Robin Young, Oliver Wright, Mark Inglefield, Jenny MacArthur, Alan Taylor, T. P., Helen Rumbelow Medical Reporter, Roland Watson, David Hands, P. B., Charles Bremner, Martin Symington, John Symons, Peter Barnard, Anthea Lawson, David Charter, Nicholas Wapshott, Michael Dynes and Michael Evans Defence Editor, Derwent May, Simon Beckett, Stuart Bailie, Russell Kempson, Paula Hawkins, Emma Mahony, Ed Potton, Paul Armstrong, Melissa de Villiers, Stephen Anderton, Amber Cowan, Jacob W. Barestrup, Simon Dalgleish, Matt Dickinson Football Correspondent, David Lawrenson, Neil Carmichael, John Hopkins Golf Correspondent, Geoffrey Dean, Rob Wright, Paul Peachey, Raymond Keene, Bernard Shaw, David Robinson, Clive Mathieson, Stephen Dawson, John Russell Taylor, Lucy Pinney, James Allcock, Francis Gilbert, Min Cooper, Diana Ross, Sally Patton, Chris Ayres Media Business Correspondent, Jo Carlowe, Richard Miles and Melanie Tringham, Michael Arditti, Oliver Holt, Richard Owen, Shane Warne, Helen Nugent, Damian Whitworth, Christopher Martin-Jenkins Chief Cricket Correspondent, Marcel Berlins, Roger Boyes, John Stern, Nick Hasell, David Hands Rugby Correspondent, John Allison, Roger Boyes and Tom Baldwin, Nick Szczepanik, Anne Ashworth, James Doran, David Charter and Russell Jenkins, Giles Whittell, Alex O'Connell, Ian Johns, Ian Mitchell, Paul McCann Media Correspondent, Matthew Parris, Angus Clarke, Michael Hartnack, Melissa Kite Political Reporter, Chris McGrath, Tim Wapshott, Russell Jenkins, Nicholas Courtney, David Adeney, Jane Owen, Nigel Walshe, Walter Gammie, Oliver Wright and Tom Baldwin, Ben MacIntyre, Helen Pridham, Ian Brodie, Michael Dynes, Ian Rushforth, Richard Miles, Graham Searjeant, JRT, Fergal Keane, Tim Jones, Martin Waller, Peter Ingham, Victoria Smith, Nigel Hawkes Science Editor, Carl Mortished International Business Editor, Danny Baker, Fran Littlewood, Lottie Moggach, Stuart Birch, Jill Crawshaw, Syd Lexis, Jack Bailey, Alyson Rudd, Sam Kiley, Robert Ballantine, Tom Chesshyre, Paul Connolly, Elizabeth Buchan, Tom Baldwin Deputy Political Editor, Robin Lodge, Fiona Beckett, Julian Ryall, John Phillips, Alan Lee Racing Correspondent, Kevin McCloud, Monson, Lea Paterson Economics Correspondent, Sally Patten, Susannah Jowitt, Nigel McCulloch, Gavin Evans, Mike Philips, sheila keating, Fraser Nelson Retail Correspondent, John Bennett, Gill Hornby, Patience Wheatcroft, Janine di Giovanni, Christopher Irvine, Susan Emmett,
... Se1 (020-7633 0274) 8 1/2 (15) (Federico… Hitchcock, 1963). Sat, 8.40pm, Cat On a ...
2000 - Gale Group | TDA
Produção Nacional
Revisado por pares
Sylvain Marcellini, Favio González, Andrés F. Sarrazin, Natalia Pabón‐Mora, Mariana Benítez, Alma Piñeyro‐Nelson, Gustavo Lazzaro Rezende, Ernesto Maldonado, Patricia N. Schneider, Mariana B. Grizante, Rodrigo Nunes da Fonseca, Francisco Vergara‐Silva, Vanessa Suaza‐Gaviria, Cecilia Zumajo‐Cardona, Eduardo E. Zattara, Sofía Casasa, Harold Suárez‐Baron, Federico D. Brown,
ABSTRACT Famous for its blind cavefish and Darwin's finches, Latin America is home to some of the richest biodiversity hotspots of our planet. The Latin American fauna and flora inspired and captivated naturalists from the nineteenth and twentieth centuries, including such notable pioneers such as Fritz Müller, Florentino Ameghino, and Léon Croizat who made a significant contribution to the study of embryology and evolutionary thinking. But, what are the historical and present contributions of the ...
Tópico(s): Evolution and Genetic Dynamics
2016 - Wiley | Journal of Experimental Zoology Part B Molecular and Developmental Evolution
From Paul Routledge, Labour Editor, , By a Staff Reporter, From Donald Macintyre, Labour Correspondent, , By David Spanier, From Michael Binyon, By Arthur Reed Air Correspondent, By Rupert Morris, By Baron Phillips, By Frank Johnson, From John Winder, Bernard Withers, Geoffrey Browning, , By Christopher Warman, Lucy Hodges, By Craig Seton, From Christopher Thomas, Dublin, By Frances Gibb, By Our Arts Reporter, By the Staff of "Nature", From David Felton, By Hugh Clayton, From Our Correspondent, From Tim Jones, By John Winder, Geoffrey Browning and Bernard Withers of our Parliamentary Staff, By Annabel Ferriman, Health Services Correspondent, By Diana Geddes Education Correspondent, By Richard Ford, By Henry Stanhope, Defence Correspondent, By Julian Haviland, Political Editor, By Philip Webster, Political Staff, By Our Medical Correspondent, From Nicholas Hirst, From Nicholas Ashford, , From Michael Leapman, , By John Witherow, From David Brown, From Michael Hornsby, By Our Foreign Staff, From Robert Schuil, From Ian Murray, , From Trevor Fishlock, , Jaffna, , From Christopher Walker, , From Our Own Correspondent, , From Nicholas Ashford, From Richard Wigg, , From A Special Correspondent La Paz, , From Peter Hazelhurst, Roger Berthoud, Ian Bradley, by Julian Haviland Political Editor, by David Watt, Roland Penrose, Michael Horsnell, Eric Marsden, E. E. THOMAS, , T. M. S. TOSSWILL, , DAVID J. CRITCHLEY, , MICHAEL CUDLIPP, , ROBERT NORTON, , MICHAEL STOURTON, , J. R. COWARD, , NEIL McINTOSH, , JAMES J. HUGHES, , ROY SHAW, , ANDREW MORGAN, , HAZEL MORGAN, , DAVID HOLBROOK, , R. PENN, , DAVID POTTER, , NICHOLAS CREAN, , By Clifford Longley, Religious Affairs Correspondent, By Our Agriculture Correspondent, From Harry Golombek, Chess Correspondent, , Sir Marcus Worsley, Michael Church, Irving Wardle, Bryan Appleyard, John Pym, Ned Chaillet, Paul Griffiths, Stephen Pettitt, John Percival, By Richard Streeton, By Lewine Mair, By Norman Fox Athletics Correspondent, By Peter Marson, By Stuart Jones Football Correspondent, From Athole Still, By John Nicholls, By Nicholas Keith, From Rex Bellamy Tennis Correspondent, By John Watson, From Pamela Macgregor-Morris, From Michael Coleman, By Michael Seely, By Peter Wilson-Smith, By Donald MacIntyre, From Frank Vogl, , From Peter Norman, , By Michael Baily Transport Correspondent, By Philip Robinson, By Peter Wainwright, By Frances Williams, By Tony Hodges, By Ronald Kershaw Northern Industrial Correspondent, From Our Correspondent, , By Bill Johnstone, By Our Electronics Correspondent, By Michael Baily, By Derek Harris Commercial Editor, BY THE FINANCIAL EDITOR, Ross Davies, Peter Norman, Pearce Wright, By Margareta Pagano, By Our Financial Staff, By Catherine Gunn, by Peter Waymark, Edited by Peter Dear, By Peter Evans, Home Affairs Correspondent, From Michael Hornsby, Johannesburg, Sept 10, Michael Prest, Sean Conway, Patrick O'Leary, M.P., Neil Behrmann, Anthony Hilton reports, Martin Huckerby, David Robinson and Geoff Brown, Geoff Brown, Louise Nicholson, Clive Aslet, John Higgins, Richard Williams, Sue Bond, Philippa Toomey, Mel Lewis, John Russell Taylor, Michael Young, Nicholas Keith, Judy Froshaug, David Wade, David Robinson, Geoffrey Wansell,
... Transcript Service, Gill & Duffus Group Ltd, Buchanan's, Federico Fellini, Bank Base Rates, Imperial Commodities Limited, Last ...
1981 - Gale Group | TDA
Gonzalo Barón‐Esquivias, Federico Gómez, Concepción Amo, Ignacio de la Torre, Agustín Guisado, Juan Adriaensens, Sílvia Gómez, Lorena García, Juande Dios Arjona, Lourdes Vaquero, Aurelio Cayuela, A. Rodrı́guez,
Tópico(s): Cardiac pacing and defibrillation studies
2011 - Elsevier BV | Cardiocore
MONK BRETTON., LYON PLAYFAIR., OWEN OWEN., -Our Correspondent., Our Own Correspondent., -Our Own Correspondent., FEDERICO ALFONSO PEZET., ANGLICANUS., HERBERT HENSLEY HENSON.,
... Christmas And New Year Cards., Society Of Arts., Baron H. De Worms On Colonial Administration., The Society ...
1891 - Gale Group | TDA
Indalecio Quesada‐Soriano, Carmen Barón, Federico García‐Maroto, Ana M. Aguilera, Luis Garcı́a-Fuentes,
Glutathione S-transferase, from the malarial parasite Plasmodium falciparum (PfGST), exerts a protective role in the organism and is thus considered an interesting target for antimalarial drug development. In contrast to other GSTs, it is present in solution as a tetramer and a dimer in equilibrium, which is induced by glutathione (GSH). These properties prevent a calorimetric titration from being conducted upon binding of ligands to this protein's G-site. Thermodynamic characterization can be an ...
Tópico(s): Pharmacogenetics and Drug Metabolism
2013 - American Chemical Society | Biochemistry
Produção Nacional
Revisado por pares
Naaman Francisco Nogueira Silva, Sérgio Henrique Silva, Daniel Barón, Isabelle Cristina Oliveira Neves, Federico Casanova,
Pereskia aculeata Miller is an edible plant species belonging to the Cactaceae family. It has the potential to be used in the food and pharmaceutical industries due to its nutritional characteristics, bioactive compounds, and mucilage content. Pereskia aculeata Miller is native to the Neotropical region, where it is traditionally employed as food in rural communities, being popularly known as ‘ora-pro-nobis’ (OPN) or the Barbados gooseberry. The leaves of OPN are distinguished by their nontoxicity ...
Tópico(s): Cassava research and cyanide
2023 - Multidisciplinary Digital Publishing Institute | Foods
Emanuele Pivetta, Alberto Goffi, Maria Tizzani, Stefania Locatelli, Giulio Porrino, Isabel Losano, Dario Leone, G Calzolari, Matteo Vesan, Fabio Steri, Arianna Ardito, Marialessia Capuano, Maria Gelardi, Giulia Silvestri, S. Dutto, Maria Avolio, Rossana Cavallo, Alice Bartalucci, Cristina Paglieri, Fulvio Morello, Lorenzo Richiardi, Milena Maule, Enrico Lupia, Federico Baldassa, Paolo Baron, Giordano Bianchi, Valeria Busso, Andrea Conterno, Paola Rizzo, Paolo Fascio Pecetto, Francesca Giachino, Andrea Iannaccone, Patrizia Ferrera, Franco Riccardini, Claudia Sacchi, Michela Sozzi, Silvia Totaro, Pasqualina Visconti, Francesca Risi, Francesca Basile, Denise Baricocchi, Alessia Beux, Valentina Beux, Paolo Bima, Irene Cara, Liliana Chichizola, Francesca Dellavalle, Federico Vilaplana Grosso, Giulia Labarile, Matteo Oddi, Marco Ottino, Ilaria Pia, Virginia Scategni, Astrid Surra,
Study objectiveAccurate diagnostic testing to identify severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is critical. Although highly specific, SARS-CoV-2 reverse transcriptase–polymerase chain reaction (RT-PCR) has been shown in clinical practice to be affected by a noninsignificant proportion of false-negative results. This study seeks to explore whether the integration of lung ultrasonography with clinical evaluation is associated with increased sensitivity for the diagnosis ...
Tópico(s): Pleural and Pulmonary Diseases
2020 - Elsevier BV | Annals of Emergency Medicine
Oheneba Boachie-Adjei, Mitsuru Yagi, Venu M. Nemani, Cristina Sacramento-Domínguez, Harry Akoto, Matthew E. Cunningham, Munish C. Gupta, W. Fred Hess, Baron Lonner, Michael Mendelow, Elias C. Papadopoulos, Federico Sanchez-Perez-Grueso, Feran Pelise, Ken Paonesa, Bettye Wright, Irene Wulff, Han Jo Kim,
Tópico(s): Spine and Intervertebral Disc Pathology
2014 - Springer Science+Business Media | Spine Deformity
Cristian Deana, Daniele Baron, Federico Barbariol, Katerina Negri, Marco Vecil, Luigi Vetrugno, Tiziana Bove, Amato De Monte,
A patient with coronary artery fistula should be considered as high risk for intraoperative hemodynamic decompensation. In this article, we report the case of a 70-year-old man affected by a complex congenital coronary artery fistula defect. The patient underwent general anesthesia for spine surgery with permissive hypotension. The development of sudden intraoperative tachyarrhythmia with hemodynamic instability required immediate resuscitation and interruption of surgery. The claim advanced is ...
Tópico(s): Congenital Heart Disease Studies
2020 - SAGE Publishing | Seminars in Cardiothoracic and Vascular Anesthesia
Zeyad Yassin, Emilia Ortiz‐Salmerón, Federico García‐Maroto, Carmen Barón, Luis Garcı́a-Fuentes,
The binding interactions between dimeric glutathione transferase from Schistosoma japonicum (Sj26GST) and bromosulfophthalein (BS) or 8-anilino-1-naphthalene sulfonate (ANS) were characterised by fluorescence spectroscopy and isothermal titration calorimetry (ITC). Both ligands inhibit the enzymatic activity of Sj26GST in a non-competitive form. A stoichiometry of 1 molecule of ligand per mole of dimeric enzyme was obtained for the binding of these ligands. The affinity of BS is higher (K(d)=3.2 microM) ...
Tópico(s): Genomics, phytochemicals, and oxidative stress
2003 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
Oheneba Boachie-Adjei, Mitsuru Yagi, Cristina Sacramento-Domínguez, Harry Akoto, Matthew E. Cunningham, Munish C. Gupta, W. Fred Hess, Baron S. Lonner, Jennifer Ayamga, Elias C. Papadopoulos, Federico Sanchez-Perez-Grueso, Feran Pelise, Kenneth J. Paonessa, Han Jo Kim,
Tópico(s): Spine and Intervertebral Disc Pathology
2014 - Springer Science+Business Media | Spine Deformity
Daniela Basso, Nicoletta Gallo, Carlo–Federico Zambon, Melvin Baron, Filippo Navaglia, E. Stockreiter, Francesco Di Mario, Massimo Rugge, Mario Plebani,
Tópico(s): Galectins and Cancer Biology
2000 - Springer Science+Business Media | International Journal of Clinical & Laboratory Research
Marileila Varella‐Garcia, Y. Cho, Xiaojun Lu, Alan Baron, Luigi Terracciano, D. Ross Camidge, P. A. Bunn, Wilbur A. Franklin, Federico Cappuzzo, Robert C. Doebele,
10533 Background: Transforming rearrangements of the ALK gene have been reported in a subset of NSCLC, commonly fusing the ALK kinase domain with EML4 promoter but rarer fusion partners (TFG and KIF5B) have also been described. ALK is a valid clinical target based on phase I clinical data with dual ALK/MET inhibitor. We investigated the cytogenetic patterns of ALK rearrangements using FISH and the molecular and clinical characteristics associated with ALK+ in an unselected NSCLC population. Methods: ...
Tópico(s): Colorectal Cancer Treatments and Studies
2010 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Filippo Sanfilippo, Stephen Huang, Antonio Messina, Federico Franchi, Francesco Oliveri, Antoine Vieillard‐Baron, Maurizio Cecconi, Marinella Astuto,
Septic induced cardiomyopathy has a wide spectrum of presentation, being associated with systolic and/or diastolic dysfunction. There is currently no evidence of association between left ventricular (LV) systolic dysfunction and mortality in septic patients. We conducted a systematic review and meta-analysis to investigate the association between systolic wave (s') obtained with Tissue Doppler Imaging (TDI) and mortality in septic patients. Secondary outcome was the association of LV ejection fraction ...
Tópico(s): Sepsis Diagnosis and Treatment
2020 - Elsevier BV | Journal of Critical Care
Alessia Diana, Nikolina Linta, Mario Cipone, Valeria Fedone, Jöerg M. Steiner, Federico Fracassi, Annamaria Grandis, Marco Baron Toaldo,
This study describes the pattern of ultrasonographic contrast enhancement of the pancreatic body and left lobe using a second-generation commercial contrast medium (Sonovue) in 10 clinically healthy cats. Following contrast medium administration, microbubbles were observed within the splenic artery. This was followed by an inflow of contrast medium into the pancreatic capillary beds, providing a uniformly contrast-enhanced pancreas at peak intensity (PI). At the time of PI, a replenishment of the ...
Tópico(s): Gallbladder and Bile Duct Disorders
2015 - BioMed Central | BMC Veterinary Research
Riccardo Baron, Conor T. Riley, Pirom Chenprakhon, Kittisak Thotsaporn, Remko T. Winter, Andrea Alfieri, Federico Forneris, Willem J. H. van Berkel, Pimchai Chaiyen, Marco W. Fraaije, Andrea Mattevi, J. Andrew McCammon,
Dioxygen (O(2)) and other gas molecules have a fundamental role in a variety of enzymatic reactions. However, it is only poorly understood which O(2) uptake mechanism enzymes employ to promote efficient catalysis and how general this is. We investigated O(2) diffusion pathways into monooxygenase and oxidase flavoenzymes, using an integrated computational and experimental approach. Enhanced-statistics molecular dynamics simulations reveal spontaneous protein-guided O(2) diffusion from the bulk solvent ...
Tópico(s): Metal-Catalyzed Oxygenation Mechanisms
2009 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Beverly W. Baron, John Anastasi, Michael J. Thirman, Yoichi Furukawa, Scott C. Fears, David C. Kim, Federico Simone, Mark Birkenbach, Anthony Montag, Annamma Sadhu, Nancy J. Zeleznik‐Le, Timothy W. McKeithan,
BCL6 , a gene on chromosome 3 band q27, encodes a Kruppel -type zinc finger transcriptional repressor. Rearrangements of this gene are frequent in various kinds of lymphomas, particularly of the large-cell B-cell type. The BCL6 nuclear phosphoprotein is expressed in a variety of tissues and is up-regulated particularly in lymph node germinal centers. The zinc fingers of BCL6 bind DNA in a sequence-specific manner. To identify targets of the BCL6 repressive effects, we used a VP16-BCL6 fusion protein ...
Tópico(s): Cancer-related gene regulation
2002 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Federico M. Ledesma, Silvina Van der Molen, Pedro J. Barón,
The European green crab Carcinus maenas is a widely spread invasive species. Studying the most recently introduced population of the species in the Atlantic coast off Patagonia, it became apparent to us that carapaces (the dorsal cover of the visceral-cavity detaching from the rest of the exoskeleton after ecdysis) accumulated on the intertidal may be used as a valuable complementary material to analyze the size structure of crabs. However, since growth rate (and consequently size at instar) of crabs ...
Tópico(s): Fish biology, ecology, and behavior
2010 - Elsevier BV | Journal of Sea Research
Indalecio Quesada‐Soriano, Carmen Barón, Ramiro Téllez‐Sanz, Federico García‐Maroto, Luis Garcı́a-Fuentes,
Tópico(s): HIV/AIDS drug development and treatment
2014 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
Carlo Guglielmini, Michele Berlanda, Federico Fracassi, Helen Poser, Shani Koren, Marco Baron Toaldo,
Improvement in cardiac function has been demonstrated after thyroxine treatment in humans with hypothyroidism using the myocardial performance index (MPI). Cardiac changes after thyroxine supplementation are poorly documented in dogs with spontaneous hypothyroidism and comparison with clinically healthy dogs is lacking.To evaluate the electrical activity and mechanical function of the heart in dogs with primary hypothyroidism at baseline (T0) and after thyroxine supplementation (T60).Forty client-owned ...
Tópico(s): Thyroid Disorders and Treatments
2019 - Wiley | Journal of Veterinary Internal Medicine
Rafał Dziadziuszko, Samir E. Witta, Federico Cappuzzo, Seong-Jin Park, Koji Tanaka, Peter V. Danenberg, Anna E. Barón, Lucio Crinó, Wilbur A. Franklin, Paul A. Bunn, Marileila Varella‐Garcia, Kathleen D. Danenberg, Fred R. Hirsch,
Abstract Purpose: Epidermal growth factor receptor (EGFR) mRNA expression and EGFR gene dosage by quantitative PCR in tumor samples obtained from patients with gefitinib-treated non–small cell lung cancer were analyzed in order to determine the association with treatment outcome, clinical, and biological features [EGFR copy number by fluorescent in situ hybridization (FISH), EGFR tyrosine kinase mutations, and EGFR protein expression]. Experimental Design: EGFR mRNA expression was measured by real- ...
Tópico(s): Colorectal Cancer Treatments and Studies
2006 - American Association for Cancer Research | Clinical Cancer Research
Federico Monaco, Bart L. Scott, Thomas R. Chauncey, Finn Bo Petersen, Barry E. Storer, Frédéric Baron, Mary E.D. Flowers, H. Joachim Deeg, David G. Maloney, Rainer Storb, Brenda M. Sandmaier,
A non-myeloablative regimen of fludarabine and 200 cGy total body irradiation combined with post-grafting immunosuppression with mycophenolate mofetil and a calcineurin inhibitor facilitates allogeneic hematopoietic cell transplantation from HLA-matched related or unrelated donors in older patients and/or those with comorbidities. However, outcomes of prior studies have been disappointing in patients with myelodysplastic syndromes or myeloproliferative neoplasms due to high incidences of progression ...
Tópico(s): Polyomavirus and related diseases
2019 - Ferrata Storti Foundation | Haematologica
Maria Rita Palattella, Federico Sismondi, Tengfei Chang, Löıc Baron, Mališa Vučinić, Pablo Modernell, Xavier Vilajosana, Thomas Watteyne,
F-Interop allows implementors of IoT protocols to test compliance and interoperability of their implementation by connecting to a remote server in the cloud which contains and runs testing tools for different IoT standards. This paper provides an overview of the F-Interop Platform and the tools. Nowadays testing tools for CoAP, 6TiSCH, OSCORE and LoRaWAN standards are already available. The F-Interop project, which has started as a H2020 project funded by the European Commission, is now supported ...
Tópico(s): Context-Aware Activity Recognition Systems
2018 - Springer Science+Business Media | Lecture notes in computer science
Stavros Trakoshis, Pablo Martínez‐Cañada, Federico Rocchi, Carola Canella, Wonsang You, Bhismadev Chakrabarti, Amber Ruigrok, Edward T. Bullmore, John Suckling, Marija Markicevic, Valerio Zerbi, Simon Baron‐Cohen, Alessandro Gozzi, Meng‐Chuan Lai, Stefano Panzeri, Michael Lombardo,
Excitation-inhibition (E:I) imbalance is theorized as an important pathophysiological mechanism in autism. Autism affects males more frequently than females and sex-related mechanisms (e.g., X-linked genes, androgen hormones) can influence E:I balance. This suggests that E:I imbalance may affect autism differently in males versus females. With a combination of in-silico modeling and in-vivo chemogenetic manipulations in mice, we first show that a time-series metric estimated from fMRI BOLD signal, ...
Tópico(s): Neural dynamics and brain function
2020 - eLife Sciences Publications Ltd | eLife
Pierre Seners, Guillaume Turc, Olivier Naggara, Hilde Hénon, Michel Piotin, Caroline Arquizan, Tae‐Hee Cho, Ana-Paula Narata, Bertrand Lapergue, Sébastien Richard, Laurence Legrand, Nicolas Bricout, Raphaël Blanc, Cyril Dargazanli, Benjamin Gory, Séverine Debiais, Marie Tisserand, Serge Bracard, X. Leclerc, Michaël Obadia, Vincent Costalat, Lise-Prune Berner, Jean-Philippe Cottier, Arturo Consoli, Xavier Ducrocq, Jean‐Louis Mas, Catherine Oppenheim, Jean‐Claude Baron, Marie Abrivard, Sonia Alamowitch, Wagih Ben Hassen, Yves Berthezène, Karine Blanc‐Lasserre, A. Boulin, Grégoire Boulouis, Stéphane Bouly, Frédéric Bourdain, David Calvet, Vladimir Charron, Mohamed Chbicheb, S. Condette–Auliac, Ovide Corabianu, Charlotte Cordonnier, Oguzhan Coskun, T. de Broucker, Jean-Pierre Decroix, Federico Di Maria, Serge Evrard, Mathieu Fissellier, Isabelle Girard, T. Lalu, P. Le Coz, Morgan Le Guen, Olivier Ille, Didier Leys, Christophe Magni, Éric Manchon, Mikaël Mazighi, F. Mounier‐Véhier, Marinette Moynier, Ioan-Paul Muresan, Norbert Nighoghossian, Elodie Ong, Canan Özsancak, Frédéric Philippeau, Fernando Pico, Georges Rodesch, Thierry Rosolacci, Candice Sabben, Denis Sablot, Philippe Tassan, Maya Tchikviladzé, Francis Turjman, Anne‐Evelyne Vallet, Adrien Wang, Marc Zins, Mathieu Zuber,
Background and Purpose— Whether all acute stroke patients with large vessel occlusion need to undergo intravenous thrombolysis before mechanical thrombectomy (MT) is debated as (1) the incidence of post-thrombolysis early recanalization (ER) is still unclear; (2) thrombolysis may be harmful in patients unlikely to recanalize; and, conversely, (3) transfer for MT may be unnecessary in patients highly likely to recanalize. Here, we determined the incidence and predictors of post-thrombolysis ER in patients ...
Tópico(s): Stroke Rehabilitation and Recovery
2018 - Lippincott Williams & Wilkins | Stroke
Ángel Muñoz-Morente, Aurora Villalobos-Sánchez, Miguel Ángel Barón-Ramos, Federico del Alcázar-Ortega,
lacion mecanica no invasiva durante 2 dias, y se anade vancomicina 1 g/12 h i.v., imipenem/cilastatina 1.000/ 1.000 mg i.v. cada 8 h y TMP-SMZ a la misma dosis que con anterioridad, consiguiendose una estabilizacion inicial con discreta mejoria clinica. Posteriormente, presenta nuevamente dificultad respiratoria intensa, pancitopenia y elevacion progresiva de la LDH (3.852 U/l), recibiendose una antigenemia en suero para citomegalovirus (CMV) positiva con 40-50 focos/50.000 pmn, iniciandose tratamiento ...
Tópico(s): Pneumonia and Respiratory Infections
2006 - Elsevier BV | Enfermedades Infecciosas y Microbiología Clínica
Amit N. Patel, Federico Benetti, Baron L. Hamman,
The first successful operations on the coronary arteries were done without the assistance of extracorporeal circulation. Many published reports described operations performed while the heart continued beating (1–8). Advances in cardiopulmonary bypass (CPB) technology, myocardial protection, and cardiopulmonary support allowed surgeons to operate on these arteries with greater precision. It is widely accepted that the single most important development in cardiac surgery was the introduction and refinement ...
Tópico(s): Cardiac Valve Diseases and Treatments
2003 - Taylor & Francis | Baylor University Medical Center Proceedings