Enrico Cortesi, Sara Ramponi, Mario Corona, Luca Moscetti, Federico Grifalchi, Annalisa Oliva, A. Lembo, Silvia Gasperoni, Andrea Marini Padovani,
In a multicenter phase II Italian trial that used a 28-day dosing schedule of gemcitabine on days 1, 8, and 15 and cisplatin on day 2, thrombocytopenia and neutropenia were the main dose-limiting toxicities observed. The aim of the present study was to determine whether using 15-day cisplatin in lieu of the standard 2-day schedule in combination with weekly gemcitabine would decrease expected myelotoxicities, particularly thrombocytopenia. Fifty-one patients with advanced non-small cell lung cancer ( ...
Tópico(s): Lung Cancer Research Studies
2001 - Elsevier BV | Lung Cancer
Maria Concetta Nigro, Andrea Marchetti, Elena Fumagalli, Ida De Luca, Alexia Bertuzzi, Maria Susanna Grimaudo, Giovanni Grignani, Lorenzo D’Ambrosio, Alessandra Merlini, Giuseppe Badalamenti, Lorena Incorvaia, Alessandra Dimino, Silvia Gasperoni, Bruno Vincenzi, Stefano Fanti, Alessandro Di Federico, Davide Campana, Maria A. Pantaleo, Margherita Nannini, Annalisa Astolfi, Alice Costa, Manuela Ianni, Massimo Del Gaudio, Dario de Biase, Maria Giulia Pirini,
Importance The D842V platelet-derived growth factor receptor α ( PDGFRA ) mutation identifies a molecular subgroup of gastrointestinal stromal tumors (GISTs), primarily resistant to standard tyrosine kinase inhibitors and with an overall more indolent behavior. Although functional imaging with 18 F-fluorodeoxyglucose–labeled positron emission tomography ([ 18 F]FDG-PET) plays a proven role in GISTs, especially in early assessment of tumor response, less is known about [ 18 F]FDG uptake according to the GIST ...
Tópico(s): Gastric Cancer Management and Outcomes
2025 - American Medical Association | JAMA Network Open
Silvia Gasperoni, Luca Messerini, Franca Castiglione, Laura Papi, Francesca Gensini, Fabio Cianchi, Antonio Taddei, Paolo Prosperi, Federico Perna, Francesco Coratti, Lorenzo Antonuzzo,
e23510 Background: Lynch Syndrome due to mutations in one of DNA mismatch repair (MMR) genes, is found in patients with colon cancer (3%).The mutations in these DNA repair genes induce genetic instability and development of ovarian, endometrial, urothelial, gastrointestinal and biliary tract carcinoma. Methods: In our center, 31 patients with Lynch syndrome are followed in Oncology Department in multidisciplinary team according to regional diagnostic therapeutic assistance paths and international ...
Tópico(s): Genetic factors in colorectal cancer
2023 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Silvia Gasperoni, Laura Papi, Francesca Castiglione, Francesca Gensini, Roberta Sestini, Luca Messerini, Caterina Bartoli, Filippo Nozzoli, Michele Dimarino, Fabio Cianchi, Antonio Taddei, Angelo Ferrara, Massimo Calistri, Lapo Bencini, Federico Perna, Martina Catalano, Roberta Giorgione, Costanza Winchler, Giulia Venturi, Enrico Mini,
e23520 Background: In adult GISTs are frequently sporadic, while rarely GISTs are linked to Carney Triad and Carney-Stratakis Syndrome and NF1. GISTs with second primary tumors are reported in 4-33% of patients in literature and genetic counseling is suggested to explore an underlying germline mutations pathway. Methods: In our Academic Hospital Centre (EURACAN member) in Florence, Italy, we are following patients with GIST and multiple primary tumors with genetic counseling (72 GISTs with second ...
Tópico(s): Sarcoma Diagnosis and Treatment
2021 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Yafang Cheng, Rong Fu, C. George, Filippo Giorgi, L. Ruby Leung, Xin‐Zhong Liang, Abdelwahid Mellouki, William J. Randel, Nicole Riemer, Robert F. Rogers, Lynn M. Russell, Ping Yang, Xiushu Qie, Yun Qian, Yongyun Hu,
... Nga (Sally) Ng Ni Dai Nicholas Falk Nicholas Gasperoni Nicholas Lutsko Nicholas Nalli Nicholas Parazoo Nicholas Siler ...
2024 - Wiley | Journal of Geophysical Research Atmospheres
... Gartenhaus, R.Garzon, R.Garzotto, M.Gascoyne, R.Gasperoni, S.Gaston, S.Gatalica, Z.Gattei, V.Gatzemeier, ...
Tópico(s): Cancer Genomics and Diagnostics
2011 - American Association for Cancer Research | Clinical Cancer Research