Cyril Deroy, Nicholas Stovall‐Kurtz, Federico Nebuloni, Cristian Soitu, Peter R. Cook, Edmond J. Walsh,
Abstract The aqueous phase in traditional microfluidics is usually confined by solid walls; flows through such systems are often predicted accurately. As solid walls limit access, open systems are being developed in which the aqueous phase is partly bounded by fluid walls (interfaces with air or immiscible liquids). Such fluid walls morph during flow due to pressure gradients, so predicting flow fields remains challenging. We recently developed a version of open microfluidics suitable for live-cell ...
Tópico(s): Innovative Microfluidic and Catalytic Techniques Innovation
2021 - Springer Nature | Microsystems & Nanoengineering
Stephen Busch, Kan Zha, Federico Perini, Rolf D. Reitz, Eric Kurtz, Alok Warey, Richard Peterson,
Tópico(s): Heat transfer and supercritical fluids
2018 - | SAE technical papers on CD-ROM/SAE technical paper series
Federico Perini, Stephen Busch, Eric Kurtz, Alok Warey, Richard C. Peterson, Rolf D. Reitz,
Tópico(s): Heat transfer and supercritical fluids
2019 - | SAE technical papers on CD-ROM/SAE technical paper series
Produção Nacional
Revisado por pares
Elisa Danese, Martina Montagnana, Julie A. Johnson, Allan E. Rettie, Carlo–Federico Zambon, Steven A. Lubitz, Guilherme Suarez‐Kurtz, Larisa H. Cavallari, Lidong Zhao, Min Huang, Yusuke Nakamura, Taisei Mushiroda, Marianne Kristiansen Kringen, Paola Borgiani, Cinzia Ciccacci, Nicholas T. Au, Taimour Langaee, Virginie Siguret, Marie‐Anne Loriot, Hersh Sagreiya, Russ B. Altman, Mohamed H. Shahin, Stuart A. Scott, Sherief Khalifa, Balram Chowbay, Ivet Suriapranata, Martina Teichert, Bruno H. Stricker, Monica Taljaard, Mariana Rodrigues Botton, J. E. Zhang, Munir Pirmohamed, X Zhang, John F. Carlquist, Benjamin D. Horne, M T M Lee, Vittorio Pengo, Gian Cesare Guidi, Pietro Minuz, Cristiano Fava,
A systematic review and a meta-analysis were performed to quantify the accumulated information from genetic association studies investigating the impact of the CYP4F2 rs2108622 (p.V433M) polymorphism on coumarin dose requirement. An additional aim was to explore the contribution of the CYP4F2 variant in comparison with, as well as after stratification for, the VKORC1 and CYP2C9 variants. Thirty studies involving 9,470 participants met prespecified inclusion criteria. As compared with CC-homozygotes, ...
Tópico(s): Health Systems, Economic Evaluations, Quality of Life
2012 - Wiley | Clinical Pharmacology & Therapeutics
Produção Nacional
Revisado por pares
Mary V. Relling, Matthias Schwab, Michelle Whirl‐Carrillo, Guilherme Suarez‐Kurtz, Ching‐Hon Pui, Charles Stein, Ann M. Moyer, William E. Evans, Teri E. Klein, Federico Guillermo Antillon‐Klussmann, Kelly E. Caudle, Motohiro Kato, Allen Eng Juh Yeoh, Kjeld Schmiegelow, Jun J. Yang,
Thiopurine methyltransferase (TPMT) activity exhibits a monogenic codominant inheritance and catabolizes thiopurines. TPMT variant alleles are associated with low enzyme activity and pronounced pharmacologic effects of thiopurines. Loss‐of‐function alleles in the NUDT15 gene are common in Asians and Hispanics and reduce the degradation of active thiopurine nucleotide metabolites, also predisposing to myelosuppression. We provide recommendations for adjusting starting doses of azathioprine, mercaptopurine, ...
Tópico(s): Adolescent and Pediatric Healthcare
2018 - Wiley | Clinical Pharmacology & Therapeutics
Federico Perini, Kan Zha, Stephen Busch, Eric Kurtz, Richard C. Peterson, Alok Warey, Rolf D. Reitz,
This work studied how in-cylinder flow structure is affected in a light-duty, swirl-supported diesel engine when equipped with three different piston geometries: the first two featuring a conventional re-entrant bowl, either with or without valve cut-outs on the piston surface and the third featuring a stepped-lip bowl. Particle image velocimetry experiments were conducted inside an optical engine to measure swirl vortex intensity and structure during the intake and compression strokes. A full computational ...
Tópico(s): Heat transfer and supercritical fluids
2017 - SAGE Publishing | International Journal of Engine Research
Thomas G. Kurtz, Federico Marchetti,
Tópico(s): Advanced Thermodynamics and Statistical Mechanics
1994 - American Mathematical Society | Proceedings of symposia in pure mathematics
Cristina Molnar, Ana Ruiz‐Gómez, Mercedes Martín, Susana Rojo‐Berciano, Federico Mayor, José F. de Celis,
The non-visual ß-arrestins are cytosolic proteins highly conserved across species that participate in a variety of signalling events, including plasma membrane receptor degradation, recycling, and signalling, and that can also act as scaffolding for kinases such as MAPK and Akt/PI3K. In Drosophila melanogaster, there is only a single non-visual ß-arrestin, encoded by kurtz, whose function is essential for neuronal activity. We have addressed the participation of Kurtz in signalling during the development ...
Tópico(s): Axon Guidance and Neuronal Signaling
2011 - Public Library of Science | PLoS Genetics
Chiara Robba, Francesca Graziano, Paola Rebora, Francesca Elli, Carlo Giussani, Mauro Oddo, Geert Meyfroidt, Raimund Helbok, Fabio Silvio Taccone, Lara Prisco, Jean‐Louis Vincent, José I. Suárez, Nino Stocchetti, Giuseppe Citerio, Mohamed Abdelaty, Samia Abed Maillard, Hatim S. Ahmed, Lea Albrecht, Aamer J. Alsudani, Edgar Daniel Amundarain, S. Anand, Jens Bo Andersen, Montserrat Pujol Anglada, Yaseen M. Arabi, Irene Aragão, Maria Dolores Arias Verdu, Karim Asehnoune, Fernanda Boldrini Assunção, Gérard Audibert, Rafael Badenes, Tamanna Bajracharya, Pierluigi Banco, Danusa Cassiana Rigo Batista, Elisabetta Bertellini, Hedgar Berty Gutiérrez, Guillaume Besch, Patrick Biston, Aaron Blandino Ortíz, V. Blazquez, Summit Bloria, Chiara Bonetti, Piergiorgio Bresil, Iole Brunetti, Virginia Buldini, Anaïs Caillard, Italo Calamai, Marco Carbonara, Anselmo Caricato, Maria Chiara Casadio, Matías Casanova, Pedro Cavaleiro, M. Celaya Lopez, Chin-Pang Chan, Rajeev Chauhan, Raphaël Cinotti, Luisa Corral, Andrea Cortegiani, Antonella Cotoia, Ilaria Alice Crippa, Valery Davidovich, Sabatino Bianco, Chrysi Diakaki, Jamil Dibu, Aikaterina Dimoula, G. Domeniconi, Ligia J. Domínguez, N.Yu. Dovbysh, Paula Andrea Duque, Heidi Shil Eddelien, Anna Efthymiou, Thomas Egmose Larsen, Muhammed Elhadi, E. Favre Eva, Maria Fencl, Petra Forjan, Rafael Limeira de Freitas, Kristina Fuest, M. Fumale, Clément Gakuba, Laurą Galarza, Monique Ferreira Garcia, George Α. Lopez, Camilla Gelormini, Andrés Gempeler, Achilleas Giannopoulos, María Estrella Giménez, Aimone Giugni, D. Glorieux, Maria Isabel Gonzalez Perez, Primož Gradišek, Marina Grandis, Donald Griesdale, А. И. Грицан, Sarah Grotheer, Deepak Gupta, Elizabeth Hallt, Christopher Hawthorne, Raimund Helbok, Morten Olskjær Holm, Christina Iasonidou, Olufemi E. Idowu, Eleonora Ioannoni, A. Izzi, Manuel Jibaja, Prakash Kafle, Darshana Hewa Kandamby, Muhammed Khan, Sergey Khomiakov, Bram Kilapong, Jakub Kletečka, Klaudyna Kojder, Angelos G. Kolias, E. Kontoudaki, George Koukoulitsios, Nataša Kovač, Sergeja Kozar, Sandro M. Krieg, Pedro Kurtz, G. Kyriazopoulos, Massimo Lamperti, Pavel Lavicka, Luís Lencastre, Michael Levin, Roger Lightfoot, Anna Lindner, P. López Ojeda, Africa Lores, Marcelo B. Lucca, Ankur Luthra, Federico Magni, Birgitte Majholm, Demosthènes Makris, Frank Maldonado, Andrea Marudi, Safala Maskey, Liese Mebis, Jorge Mejía-Mantilla, Ray Mendoza, Nikola Milivojević, John-Paul Miroz, Berta Monleón, José María de las Heras Montes, Paola Morelli, Alessandro Motta, Eleni Mouloudi, Susanne Muehlschlegel, Silvio A. Ñamendys‐Silva, Gábor Nardai, Khadka Nilam, DaiWai M. Olson, Ahmad Ozair, Carlos Pacheco, J. Padilla Juan, Eleni Palli, Nidhi Panda, Nikolaos Pantelas, Laura Pariente, Douglas C. Pearson, Rodrigo Pérez-Araos, Edoardo Picetti, J.L. Pinedo Portilla, B. Pons, Federico Pozzi, Eva Provaznikova, M Quartarone, Hervé Quintard, Lalit Kumar Rajbanshi, Michael C. Reade, Samo Ribarič, Andrea Rigamonti, Luis Rivera, John Roberts, Yam Bahadur Roka, Oļegs Sabeļņikovs, Harsh Sapra, Stefan J. Schaller, Mypinder S. Sekhon, Walid Sellami, Ian Seppelt, Ainhoa Serrano, Kopal Sharma, Gentle Sunder Shrestha, Hoi‐Ping Shum, Sanderson Alencar Santos da Silva, Marcela Simoes, Sanjeev Sivakumar, Richard Siviter, Josef Škola, Mara Škoti, Margit Smitt, Rafael Soley, Romain Sonneville, Alessandra Soragni, Benjamin Soyer, Věra Špatenková, E Stamou, Eleonora Stival, Z. Olson, Krisztián Tánczos, C. Thompson, Jakob Edelberg Thomsen, S Tsikriki, Stijn Van de Velde, Walter Videtta, Federico Villa, Kamil Vrbica, Charikleia S. Vrettou, H Hoffmeyer, Stefan Wolf, Stefan Wolf, Sâmia Yasin Wayhs, Simone Maria Zerbi,
Summary Background The indications for intracranial pressure (ICP) monitoring in patients with acute brain injury and the effects of ICP on patients' outcomes are uncertain. The aims of this study were to describe current ICP monitoring practises for patients with acute brain injury at centres around the world and to assess variations in indications for ICP monitoring and interventions, and their association with long-term patient outcomes. Methods We did a prospective, observational cohort study at 146 ...
Tópico(s): Neurosurgical Procedures and Complications
2021 - Elsevier BV | The Lancet Neurology
Federico Perini, Stephen Busch, Kan Zha, Rolf D. Reitz, Eric Kurtz,
Tópico(s): Combustion and flame dynamics
2019 - | SAE technical papers on CD-ROM/SAE technical paper series
F. Husseini, Jean‐Pierre Delord, Cécile Fournel-Federico, Jérôme Guitton, Philippe Erbs, M. Homerin, Céline Halluard, Chloé Jemming, Clélia Orange, Jean–Marc Limacher, J.E. Kurtz,
BackgroundTG4023 is a modified vaccinia virus Ankara (MVA) containing the yeast-originated transgene FCU1, expressing cytosine deaminase and uracil phosphoribosyltransferase enzymes that transform the prodrug flucytosine (5-FC) into cytotoxic 5-fluorouracil (5-FU) and 5-fluorouridine-5′-monophosphate, respectively. This first-in-human study aimed to assess the maximum tolerated dose (MTD) of intratumoral (IT) TG4023 and the safety, feasibility, and proof-of-concept (PoC) of TG4023/5-FC combination to ...
Tópico(s): Animal Virus Infections Studies
2016 - Elsevier BV | Annals of Oncology
Stephen Busch, Federico Perini, Rolf D. Reitz, Eric Kurtz,
Tópico(s): Combustion and flame dynamics
2020 - SAE International | SAE International Journal of Engines
Tópico(s): Plant Taxonomy and Phylogenetics
1893 - | Revista del Museo de La Plata
Brian M. Wolpin, Cosmeri Rizzato, Peter Kraft, Charles Kooperberg, Gloria M. Petersen, Zhaoming Wang, Alan A. Arslan, Laura E. Beane Freeman, Paige M. Bracci, Julie E. Buring, Federico Canzian, Eric J. Duell, Steven Gallinger, Graham G. Giles, Gary E. Goodman, Phyllis J. Goodman, Eric J. Jacobs, Aruna Kamineni, Alison P. Klein, Laurence N. Kolonel, Matthew H. Kulke, Donghui Li, Núria Malats, Sara H. Olson, Harvey A. Risch, Howard D. Sesso, Kala Visvanathan, Emily White, Wei Zheng, Christian C. Abnet, Demetrius Albanes, Gabriella Andreotti, Melissa A. Austin, Richard Barfield, Daniela Basso, Sonja I. Berndt, Marie‐Christine Boutron‐Ruault, Michelle Brotzman, Markus W. Büchler, H. Bas Bueno‐de‐Mesquita, Peter Bugert, Laurie Burdette, Daniele Campa, Neil E. Caporaso, Gabriele Capurso, Charles C. Chung, Michelle Cotterchio, Eithne Costello, Joanne W. Elena, Niccola Funel, J. Michael Gaziano, Nathalia A. Giese, Edward L. Giovannucci, Michael Goggins, Megan J. Gorman, Myron D. Gross, Christopher A. Haiman, Manal M. Hassan, Kathy J. Helzlsouer, Brian E. Henderson, Elizabeth A. Holly, Nan Hu, David J. Hunter, Federico Innocenti, Mazda Jenab, Rudolf Kaaks, Timothy J. Key, Kay‐Tee Khaw, Eric A. Klein, Manolis Kogevinas, Vittorio Krogh, Juozas Kupčinskas, Robert C. Kurtz, Andrea Z. LaCroix, Maria Teresa Landi, Stefano Landi, Loı̈c Le Marchand, Andrea Mambrini, Satu Männistö, Roger L. Milne, Yusuke Nakamura, Ann L. Oberg, Kouros Owzar, Alpa V. Patel, Petra H. Peeters, Ulrike Peters, Raffaele Pezzilli, Ada Piepoli, Miquel Porta, Francisco X. Real, Elio Ríboli, Nathaniel Rothman, Aldo Scarpa, Xiao‐Ou Shu, Debra T. Silverman, Pavel Souček, Malin Sund, Renata Talar‐Wojnarowska, Philip R. Taylor, George Theodoropoulos, Mark Thornquist, Anne Tjønneland, Geoffrey S. Tobias, Dimitrios Trichopoulos, Pavel Vodička, Jean Wactawski‐Wende, Nicolas Wentzensen, Chen Wu, Herbert Yu, Kai Yu, Anne Zeleniuch‐Jacquotte, Robert N. Hoover, Patricia Hartge, Charles S. Fuchs, Stephen J. Chanock, Rachael S. Stolzenberg-Solomon, Laufey T. Ámundadóttir,
We performed a multistage genome-wide association study including 7,683 individuals with pancreatic cancer and 14,397 controls of European descent. Four new loci reached genome-wide significance: rs6971499 at 7q32.3 (LINC-PINT, per-allele odds ratio (OR) = 0.79, 95% confidence interval (CI) 0.74-0.84, P = 3.0 × 10(-12)), rs7190458 at 16q23.1 (BCAR1/CTRB1/CTRB2, OR = 1.46, 95% CI 1.30-1.65, P = 1.1 × 10(-10)), rs9581943 at 13q12.2 (PDX1, OR = 1.15, 95% CI 1.10-1.20, P = 2.4 × 10(-9)) and rs16986825 at 22q12.1 (ZNRF3, OR = ...
Tópico(s): Epigenetics and DNA Methylation
2014 - Nature Portfolio | Nature Genetics
Kevin B. Jacobs, Meredith Yeager, Weiyin Zhou, Sholom Wacholder, Zhaoming Wang, Benjamín Rodríguez‐Santiago, Amy Hutchinson, Xiang Deng, Chenwei Liu, Marie-Josèphe Horner, Michael Cullen, Caroline G. Epstein, Laurie Burdett, Michael Dean, Nilanjan Chatterjee, Joshua N. Sampson, Charles C. Chung, Joseph Kovaks, Susan M. Gapstur, Victoria L. Stevens, Lauren T. Teras, Mia M. Gaudet, Demetrius Albanes, Stephanie J. Weinstein, Jarmo Virtamo, Philip R. Taylor, Neal D. Freedman, Christian C. Abnet, Alisa M. Goldstein, Nan Hu, Kai Yu, Jian‐Min Yuan, Linda M. Liao, Ti Ding, You‐Lin Qiao, Yu-Tang Gao, Woon‐Puay Koh, Yong-Bing Xiang, Ze-Zhong Tang, Jin‐Hu Fan, Melinda C. Aldrich, Christopher I. Amos, William J. Blot, Cathryn H. Bock, Elizabeth M. Gillanders, Curtis C. Harris, Christopher A. Haiman, Brian E. Henderson, Laurence N. Kolonel, Loı̈c Le Marchand, Lorna H. McNeill, Benjamin A. Rybicki, Ann G. Schwartz, Lisa B. Signorello, Margaret R. Spitz, John K. Wiencke, Margaret Wrensch, Xifeng Wu, Krista A. Zanetti, Regina G. Ziegler, Jonine D. Figueroa, Montserrat García‐Closas, Núria Malats, Gaëlle Marenne, Ludmila Prokunina‐Olsson, Dalsu Baris, Molly Schwenn, Alison Johnson, Maria Teresa Landi, Lynn R. Goldin, Dario Consonni, Pier Alberto Bertazzi, Melissa Rotunno, Preetha Rajaraman, Ulrika Andersson, Laura E. Beane Freeman, Christine D. Berg, Julie E. Buring, Mary Ann Butler, Tania Carreón, Maria Feychting, Anders Ahlbom, J. Michael Gaziano, Graham G. Giles, Göran Hallmans, Susan E. Hankinson, Patricia Hartge, Roger Henriksson, Peter D. Inskip, Christoffer Johansen, Annelie Landgren, Roberta McKean‐Cowdin, Dominique S. Michaud, Beatrice S. Melin, Ulrike Peters, Avima M. Ruder, Howard D. Sesso, Gianluca Severi, Xiao‐Ou Shu, Kala Visvanathan, Emily White, Alicja Wolk, Anne Zeleniuch‐Jacquotte, Wei Zheng, Debra T. Silverman, Manolis Kogevinas, Juan R. González, Olaya Villa, Donghui Li, Eric J. Duell, Harvey A. Risch, Sara H. Olson, Charles Kooperberg, Brian M. Wolpin, Li Jiao, Manal M. Hassan, William Wheeler, Alan A. Arslan, H. Bas Bueno‐de‐Mesquita, Charles S. Fuchs, Steven Gallinger, Myron D. Gross, Elizabeth A. Holly, Alison P. Klein, Andrea Z. LaCroix, Margaret T. Mandelson, Gloria M. Petersen, Marie‐Christine Boutron‐Ruault, Paige M. Bracci, Federico Canzian, Kenneth Chang, Michelle Cotterchio, Edward L. Giovannucci, Michael Goggins, Judith A. Hoffman Bolton, Mazda Jenab, Kay‐Tee Khaw, Vittorio Krogh, Robert C. Kurtz, Robert R. McWilliams, Julie B. Mendelsohn, Kari G. Rabe, Elio Ríboli, Anne Tjønneland, Geoffrey S. Tobias, Dimitrios Trichopoulos, Joanne W. Elena, Herbert Yu, Laufey T. Ámundadóttir, Rachael Z. Stolzenberg‐Solomon, Peter Kraft, Fredrick R. Schumacher, Daniel O. Stram, Sharon A. Savage, Kari G. Rabe, Irene L. Andrulis, Jay S. Wunder, Ana Patiño‐García, Luis Sierrasesúmaga, Donald A. Barkauskas, Richard Görlick, Mark P. Purdue, Wong‐Ho Chow, Lee E. Moore, Kendra Schwartz, Faith G. Davis, Ann W. Hsing, Sonja I. Berndt, Amanda Black, Nicolas Wentzensen, Louise A. Brinton, Jolanta Lissowska, Beata Pepłońska, Katherine A. McGlynn, Michael B. Cook, Barry I. Graubard, Christian P. Kratz, Mark H. Greene, Ralph L. Erickson, David J. Hunter, Gilles Thomas, Robert N. Hoover, Francisco X. Real, Joseph F. Fraumeni, Neil E. Caporaso, Margaret A. Tucker, Nathaniel Rothman, Luis A. Pérez‐Jurado, Stephen J. Chanock,
Luis Pérez-Jurado, Stephen Chanock and colleagues detect clonal chromosomal abnormalities in peripheral blood or buccal samples from individuals in the general population. They show that the frequency of such events increases with age and is associated with elevated risk of developing subsequent hematological cancers. In an analysis of 31,717 cancer cases and 26,136 cancer-free controls from 13 genome-wide association studies, we observed large chromosomal abnormalities in a subset of clones in ...
Tópico(s): DNA Repair Mechanisms
2012 - Nature Portfolio | Nature Genetics
Naomi Walsh, Han Zhang, Paula L. Hyland, Qi Yang, Evelina Mocci, Mingfeng Zhang, Erica J. Childs, Irene Collins, Zhaoming Wang, Alan A. Arslan, Laura E. Beane Freeman, Paige M. Bracci, Paul Brennan, Federico Canzian, Eric J. Duell, Steven Gallinger, Graham G. Giles, Michael Goggins, Gary E. Goodman, Phyllis J. Goodman, Rayjean J. Hung, Charles Kooperberg, Robert C. Kurtz, Núria Malats, Loı̈c Le Marchand, Rachel Ε. Neale, Sara H. Olson, Ghislaine Scélo, Xiao Ou Shu, Stephen K. Van Den Eeden, Kala Visvanathan, Emily White, Wei Zheng, Demetrius Albanes, Gabriella Andreotti, Ana Babić, William R. Bamlet, Sonja I. Berndt, Ayelet Borgida, Marie‐Christine Boutron‐Ruault, Lauren K. Brais, Paul Brennan, Bas Bueno‐de‐Mesquita, Julie E. Buring, Kari G. Chaffee, Stephen J. Chanock, Sean P. Cleary, Michelle Cotterchio, Lenka Foretová, Charles S. Fuchs, J. Michael Gaziano, Edward Giovannucci, Michael Goggins, Thilo Hackert, Christopher A. Haiman, Patricia Hartge, Manal Hasan, Kathy J. Helzlsouer, Joseph M. Herman, Ivana Holcátová, Elizabeth A. Holly, Robert N. Hoover, Rayjean J. Hung, Vladimír Janout, Eric A. Klein, Robert C. Kurtz, Daniel A. Laheru, I‐Min Lee, Lingeng Lu, Núria Malats, Satu Männistö, Roger L. Milne, Ann L. Oberg, Irene Orlow, Alpa V. Patel, Ulrike Peters, Miquel Porta, Francisco X. Real, Nathaniel Rothman, Howard D. Sesso, Gianluca Severi, Debra T. Silverman, Oliver Strobel, Malin Sund, Mark Thornquist, Geoffrey S. Tobias, Jean Wactawski‐Wende, Nicholas J. Wareham, Elisabete Weiderpass, Nicolas Wentzensen, William Wheeler, Herbert Yu, Anne Zeleniuch‐Jacquotte, Peter Kraft, Donghui Li, Eric J. Jacobs, Gloria M. Petersen, Brian M. Wolpin, Harvey A. Risch, Laufey T. Ámundadóttir, Kai Yu, Alison P. Klein, Rachael Z. Stolzenberg‐Solomon,
Genome-wide association studies (GWAS) identify associations of individual single-nucleotide polymorphisms (SNPs) with cancer risk but usually only explain a fraction of the inherited variability. Pathway analysis of genetic variants is a powerful tool to identify networks of susceptibility genes. We conducted a large agnostic pathway-based meta-analysis of GWAS data using the summary-based adaptive rank truncated product method to identify gene sets and pathways associated with pancreatic ductal ...
Tópico(s): Pancreatic and Hepatic Oncology Research
2018 - Oxford University Press | JNCI Journal of the National Cancer Institute
Fotis Topouzis, Shlomo Melamed, Helen V. Danesh‐Meyer, Anthony P. Wells, V P Kozobolis, Helga Wieland, Russell Andrew, David T. Wells, Vassilios Kozobolis, George Maskaleris, Εfstathios T. Detorakis, Fotis Topouzis, Eleftherios Anastasopoulos, Theofanis Pappas, Artemios Kandarakis, J. Koutroumanos, Miltiadis Aspiotis, Chrisavgi Pappa, E. Vaikoussis, Thrassyvoulos Paschalidis, P. Bournas, Nikos Kazatzis, Ivan Goldberg, Stuart L. Graham, Paul R. Healey, Julian L Rait, Allan Bank, Paul R. Healey, Jonathan G. Crowston, Magdalena Guzowski, R.A. Covar, Anne Lee, Jen Wan, Domit Azar, P Stadion, François Lizin, Veva De Groot, Patrick Schraepen, Bruno Reyntjens, Anna-Maria Kestelyn-Stevens, Fien Witters, Pait Teesalu, Imbi Kuus, Maris Oll, Ulle Aamer, Elo Alas, Marko Pastak, B Delbosc, Albrecht Gerstenberger, Peter Jungmann, Ludwig T. Hamacher, Ursula Hellmair, Andreas U.M. Bayer, W Foerster, Thomas Christ, A. Reibaldí, Maurizio G. Uva, Antonio Longo, Daniela Lombardo, F Trimarchi, Giovanni Milano, Antonella Clemente, Gemma Caterina Maria Rossi, Ilaria Scatassi, Francesca Montemurro, Federico Grignolo, B. Brogliatti, Teresa Rolle, Cristina Favero, Elisa Giacosa, Angela Fornero, Shlomo Melamed, Mordehai Goldenfeld, Hani Levkovitch Verbin, Zohar Vilner, Ran Knaan, Iris Moroz, Orna Geyer, Eitan Segev, Shimon Kurtz, Meira Neudorfer, Gabi Shemesh, Shiri Zayit, Lāsma Volksone, Lija Karlsone, Guna Laganovska, Kristīne Baumane, Ilze Egite, Ingrida Janulevičienė, Loreta Kuzmienė, Helen V. Danesh‐Meyer, Anthony P. Wells, Andrew F Riley, Anthony Bedggood, Helen Long, Nina Ashraff, Pedro A.L. Abrantes, Maria Reina, José Pedro Silva, J Ilharco, Paul Tec Kwan Chew, Lennard Thean, Lim Boon Ang, Joseph Manuel, Loon Seng Chee, Clement Tan, Yeong Suet Ming, Steve K.L. Seah, Francis T.S. Oen, Lim Boon Ang, Rahat Husain, Hoh Sek Tian, Tin Aung, Julián Sánchez Garcia, J. García–Sánchez, J.M. Martínez-de-la-Casa, Alfredo Castillo Gómez, Francisco Manuel Honrubia López, Vicente Polo, Luís E. Pablo, Maria Luisa, Gómez Martínez, José Manuel, Larrosa Póvez, Alfonso Arias Puente, C. Carrasco, María del Carmen, García Yolanda, Andrés Alba, Elena Gurdiel, E. Dorronzoro, María Jesús Muniesa, Da‐Wen Lu, L G Clearkin, Yogesh J Patwala,
Purpose The objective of the study was to compare the intraocular pressure (IOP)-lowering efficacy and safety of travoprost 0.004%/timolol 0.5% ophthalmic solution (Trav/Tim) to latanoprost 0.005%/timolol 0.5% ophthalmic solution (Lat/Tim), dosed once daily in the morning, in patients with open-angle glaucoma (OAG) or ocular hypertension (OH). Methods This was a randomized, double-masked, multicenter, parallel group, active-controlled study conducted at 41 sites. At the eligibility visit the patients ...
Tópico(s): Retinal Diseases and Treatments
2007 - SAGE Publishing | European Journal of Ophthalmology
Alison P. Klein, Sara Lindstrӧm, Julie B. Mendelsohn, Emily Steplowski, Alan A. Arslan, H. Bas Bueno-de-Mesquita, Charles S. Fuchs, Steven Gallinger, Myron D. Gross, Kathy J. Helzlsouer, Elizabeth A. Holly, Eric J. Jacobs, Andrea Z. LaCroix, Donghui Li, Margaret T. Mandelson, Sara H. Olson, Gloria M. Petersen, Harvey A. Risch, Rachael Z. Stolzenberg‐Solomon, Wei Zheng, Laufey T. Ámundadóttir, Demetrius Albanes, Naomi E. Allen, William R. Bamlet, Marie‐Christine Boutron‐Ruault, Julie E. Buring, Paige M. Bracci, Federico Canzian, Sandra Clipp, Michelle Cotterchio, Eric J. Duell, Joanne W. Elena, J. Michael Gaziano, Edward L. Giovannucci, Michael Goggins, Göran Hallmans, Manal M. Hassan, Amy Hutchinson, David J. Hunter, Charles Kooperberg, Robert C. Kurtz, Simin Liu, Kim Overvad, Domenico Palli, Alpa V. Patel, Kari G. Rabe, Xiao-Ou Shu, Nadia Slimani, Geoffrey S. Tobias, Dimitrios Trichopoulos, Stephen K. Van Den Eeden, Paolo Vineis, Jarmo Virtamo, Jean Wactawski‐Wende, Brian M. Wolpin, Herbert Yu, Kai Yu, Anne Zeleniuch‐Jacquotte, Stephen J. Chanock, Robert N. Hoover, Patricia Hartge, Peter Kraft,
Purpose We developed an absolute risk model to identify individuals in the general population at elevated risk of pancreatic cancer. Patients and Methods Using data on 3,349 cases and 3,654 controls from the PanScan Consortium, we developed a relative risk model for men and women of European ancestry based on non-genetic and genetic risk factors for pancreatic cancer. We estimated absolute risks based on these relative risks and population incidence rates. Results Our risk model included current ...
Tópico(s): Neuroendocrine Tumor Research Advances
2013 - Public Library of Science | PLoS ONE
Daniel Kaufmann, Aart Kraay, Massimo Mastruzzi,
... 143.https://doi.org/10.1017/S1049096509090106Giuseppe Bellantuono, Federico Boffa Residential Energy Markets in Europe: Designing Effective Institutions, SSRN Electronic Journal 1 (Jan 2008).https://doi.org/10.2139/ssrn.1121272 Revue des revues, Revue française de science politique Vol. 57, no.33 (Aug 2007): 517–526.https://doi.org/10.3917/rfsp.573.0517Marcus J. KurtzMarcus J. Kurtz is associate professor of political science, The Ohio ...
Tópico(s): Economic Growth and Development
2007 - University of Chicago Press | The Journal of Politics
Donghui Li, Eric J. Duell, Kai Yu, Harvey A. Risch, Sara H. Olson, Charles Kooperberg, Brian M. Wolpin, Li Jiao, Xiaoqun Dong, Bill Wheeler, Alan A. Arslan, H. Bas Bueno-de-Mesquita, Charles S. Fuchs, Steven Gallinger, Myron D. Gross, Patricia Hartge, Robert N. Hoover, Elizabeth A. Holly, Eric J. Jacobs, Alison P. Klein, Andrea Z. LaCroix, Margaret T. Mandelson, Gloria M. Petersen, Wei Zheng, Ilir Agalliu, Demetrius Albanes, Marie‐Christine Boutron‐Ruault, Paige M. Bracci, Julie E. Buring, Federico Canzian, Kenneth J. Chang, Stephen J. Chanock, Michelle Cotterchio, J. Michael Gaziano, Edward L. Giovannucci, Michael Goggins, Göran Hallmans, Susan E. Hankinson, Judith A. Hoffman Bolton, David J. Hunter, Amy Hutchinson, Kevin B. Jacobs, Mazda Jenab, Kay‐Tee Khaw, Peter Kraft, Vittorio Krogh, Robert C. Kurtz, Robert R. McWilliams, Julie B. Mendelsohn, Alpa V. Patel, Kari G. Rabe, Elio Ríboli, Xiao‐Ou Shu, Anne Tjønneland, Geoffrey S. Tobias, Dimitrios Trichopoulos, Jarmo Virtamo, Kala Visvanathan, Joanne L. Watters, Herbert Yu, Anne Zeleniuch‐Jacquotte, Laufey T. Ámundadóttir, Rachael Z. Stolzenberg‐Solomon,
Four loci have been associated with pancreatic cancer through genome-wide association studies (GWAS). Pathway-based analysis of GWAS data is a complementary approach to identify groups of genes or biological pathways enriched with disease-associated single-nucleotide polymorphisms (SNPs) whose individual effect sizes may be too small to be detected by standard single-locus methods. We used the adaptive rank truncated product method in a pathway-based analysis of GWAS data from 3851 pancreatic cancer ...
Tópico(s): Pancreatic function and diabetes
2012 - Oxford University Press | Carcinogenesis
Donald V. Kurtz, Thomas H. Charlton, James F. Hopgood, Stephen A. Kowalewski, Deborah L. Nichols, Robert S. Santley, Marc J. Swartz, Bruce G. Trigger,
... at Teotihuacan [and Comments and Reply]Donald V. Kurtz, Thomas H. Charlton, James F. Hopgood, Stephen A. ... Marc J. Swartz, and Bruce G. TriggerDonald V. Kurtz Search for more articles by this author , Thomas ... following articles citing this article:Abigail Meza‐Peñaloza, Federico Zertuche, Christopher Morehart Population level comparisons in central ...
Tópico(s): Wildlife Ecology and Conservation
1987 - University of Chicago Press | Current Anthropology
Mingfeng Zhang, Zhaoming Wang, Ofure Obazee, Jinping Jia, Erica J. Childs, Jason W. Hoskins, Gisella Figlioli, Evelina Mocci, Irene Collins, Charles C. Chung, Christopher Hautman, Alan A. Arslan, Laura E. Beane Freeman, Paige M. Bracci, Julie E. Buring, Eric J. Duell, Steven Gallinger, Graham G. Giles, Gary E. Goodman, Phyllis J. Goodman, Aruna Kamineni, Laurence N. Kolonel, Matthew H. Kulke, Núria Malats, Sara H. Olson, Howard D. Sesso, Kala Visvanathan, Emily White, Wei Zheng, Christian C. Abnet, Demetrius Albanes, Gabriella Andreotti, Lauren K. Brais, H. Bas Bueno-de-Mesquita, Daniela Basso, Sonja I. Berndt, Marie‐Christine Boutron‐Ruault, Maarten F. Bijlsma, Hermann Brenner, Laurie Burdette, Daniele Campa, Neil E. Caporaso, Gabriele Capurso, Giulia Martina Cavestro, Michelle Cotterchio, Eithne Costello, Joanne W. Elena, Ugo Boggi, J. Michael Gaziano, Maria Gazouli, Edward L. Giovannucci, Michael Goggins, Myron D. Gross, Christopher A. Haiman, Manal M. Hassan, Kathy J. Helzlsouer, Nan Hu, David J. Hunter, Elżbieta Iskierka‐Jażdżewska, Mazda Jenab, Rudolf Kaaks, Timothy J. Key, Kay‐Tee Khaw, Eric A. Klein, Manolis Kogevinas, Vittorio Krogh, Juozas Kupčinskas, Robert C. Kurtz, Maria Teresa Landi, Stefano Landi, Loı̈c Le Marchand, Andrea Mambrini, Satu Männistö, Roger L. Milne, Rachel Ε. Neale, Ann L. Oberg, Salvatore Panico, Alpa V. Patel, Petra H. Peeters, Ulrike Peters, Raffaele Pezzilli, Miquel Porta, Mark P. Purdue, J. Ramón Quirós, Elio Ríboli, Nathaniel Rothman, Aldo Scarpa, Ghislaine Scélo, Xiao‐Ou Shu, Debra T. Silverman, Pavel Souček, Oliver Strobel, Malin Sund, Ewa Małecka‐Panas, Philip R. Taylor, Francesca Tavano, Ruth C. Travis, Mark Thornquist, Anne Tjønneland, Geoffrey S. Tobias, Dimitrios Trichopoulos, Yogesh K. Vashist, Pavel Vodička, Jean Wactawski‐Wende, Nicolas Wentzensen, Herbert Yu, Kai Yu, Anne Zeleniuch‐Jacquotte, Charles Kooperberg, Harvey A. Risch, Eric J. Jacobs, Donghui Li, Charles S. Fuchs, Robert N. Hoover, Patricia Hartge, Stephen J. Chanock, Gloria M. Petersen, Rachael S. Stolzenberg-Solomon, Brian M. Wolpin, Peter Kraft, Alison P. Klein, Federico Canzian, Laufey T. Ámundadóttir,
... Vittorio Krogh 70 , Juozas Kupcinskas 71 , Robert C. Kurtz 72 , Maria T. Landi 2 , Stefano Landi 40 , ... Kraft 24,98 , Alison P. Klein 5,99 , Federico Canzian 4 and Laufey T. Amundadottir 1 1 ... USA 77 Dipartimento di Medicina Clinica E Chirurgia, Federico II Univeristy, Naples, Italy 78 Epidemiology Research Program, ...
Tópico(s): RNA modifications and cancer
2016 - Impact Journals LLC | Oncotarget
Leandro R. Soria, Sonam Gurung, Giulia De Sabbata, Dany Perocheau, Angela De Angelis, Giovanni Bruno, Elena Polishchuk, Debora Paris, Paola Cuomo, Andréa Motta, Michael Orford, Youssef Khalil, Simon Eaton, Philippa B. Mills, Simon N. Waddington, Carmine Settembre, Andrés F. Muro, Julien Baruteau, Nicola Brunetti‐Pierri,
... Consistent with previous reports (Yang et al, 2016; Kurtz et al, 2019), spf-ash mice showed marked ...
Tópico(s): Pancreatic function and diabetes
2020 - Springer Nature | EMBO Molecular Medicine
Chiara Robba, Francesca Graziano, Angelo Guglielmi, Paola Rebora, Stefania Galimberti, Fabio Silvio Taccone, Giuseppe Citerio, Walter Videtta, G. Domeniconi, María Estrella Giménez, Mariela Fumale, Edgar Daniel Amundarain, Matías Casanova, Michael C. Reade, Elizabeth Hallt, David Pearson, Ian Seppelt, Raimund Helbok, Valery Davidovich, Geert Meyfroidt, Ilaria Alice Crippa, Liese Mebis, Patrick Biston, Stijn Van de Velde, Glorieux Denis, Pedro Kurtz, Sâmia Yasin Wayhs, Mypinder S. Sekhon, Donald Griesdale, Andrea Rigamonti, José Miguel Montes, Rodrigo Pérez-Araos, Jorge Mejía-Mantilla, Andrés Gempeler, Ray Mendoza, Nataša Kovač, Hedgar Berty Gutiérrez, Věra Špatenková, Marek Fencl, Roman Gál, Ondřej Hrdý, Kamil Vrbica, Josef Škola, Eva Provaznikova, Jakub Kletečka, Pavel Lavicka, Věra Špatenková, Piergiorgio Bresil, Marianne Levin, Piergiorgio Bresil, Josefine Thomsen, Thomas Egmose Larsen, H Hoffmeyer, Morten Olskjær Holm, J. Andersen, Birgitte Majholm, Margit Smitt, Heidi Shil Eddelien, Manuel Jibaja, Freddy Maldonado, María Fernanda García, Karim Asehnoune, Bertrand Pons, Gérard Audibert, Manon Lucca, Guillaume Besch, Pierluigi Banco, Karim Asehnoune, Raphaël Cinotti, Hervé Q uintard, Benjamin Soyer, Anaïs Caillard, Clément Gakuba, Romain Sonneville, Stefan Wolf, Kristina Fuest, Lea Albrecht, Sarah Grotheer, Sandro M. Krieg, Stefan J. Schaller, Charikleia S. Vrettou, Eftychia Kontoudaki, Anna Efthymiou, Elena Palli, Demosthènes Makris, Chrysi Diakaki, Christina Iasonidou, Aikaterini Dimoula, Georgios Koukoulitsios, G. Kyriazopoulos, Nikolas Pantelas, S Tsikriki, E Stamou, Charikleia S. Vrettou, Achileas Giannopoulos, Eleni Mouloudi, Hoi‐Ping Shum, Yan Chan Cheuk, Hewa Kandamby Darshana, Krisztián Tánczos, Gábor Nardai, Zoltán Szentkereszty, Harsh Sapra, Deepak Gupta, Kaveri Sharma, Saurabh Anand, Ankur Luthra, Summit Bloria, Rajeev Chauhan, Nidhi Panda, Ahmad Ozair, Bram Kilapong, Anass Alsudani, Giuseppe Citerio, Alessandra Soragni, Alessandro Motta, Andrea Marudi, Elisabetta Bertellini, Anselmo Caricato, Camilla Gelormini, Eleonora Ioannoni, Eleonora Stival, Serena Silva, Federico Pozzi, Iole Brunetti, Andrea Cortegiani, Edoardo Picetti, Federico Villa, Italo Calamai, Maria Chiara Casadio, M Quartarone, Marina Grandis, Federico Magni, Silvia Del Bianco, Claudia Bonetti, Virginia Buldini, Aimone Giugni, Simone Maria Zerbi, Marco Carbonara, Antonella Cotoia, Antonio Izzi, Oļegs Sabeļņikovs, Muhammed Elhadi, Hazem Ahmed, Silvio A. Ñamendys‐Silva, Gilberto Adrian Gasca López, Gentle Sunder Shrestha, Shirish Maskey, Tamanna Bajracharya, Khadka Nilam, Prakash Kafle, Laleet Rajbanshi, Yam Bahadur Roka, Olufemi E. Idowu, Khan Muhammad Mukhtar, Juan Luis Pinedo Portilla, Klaudyna Kojder, Irene Aragão, Ricardo Freitas, Marco Simões, Dario Batista, Cecília Pacheco, Fátima Assunção, Luís Lencastre, Pedro Cavaleiro, Mohamed Abdelaty, А. И. Грицан, Sergey Khomiakov Sergey, Dovbysh Nikolay, Yaseen M. Arabi, Primož Gradišek, Petra Forjan, Mara Škoti, Suada Fileković Ribarič, Primož Gradišek, Nataša Milivojevic, Sergeja Kozar, Rafael Badenes, Aaron Blandino Ortíz, Mikel Celaya Lopez, Laurą Galarza, Luisa Corral, Africa Lores, Ricard Soley, Laura Pariente, Pablo López Ojeda, Maria Dolores Arias Verdu, Luis Javier Yuste Dominguez, Maria Isabel Gonzalez Perez, Mireia Anglada, Patricia Duque, Ainhoa Serrano, Berta Monleón, Vanessa Blázquez, Mauro Oddo, Samia Abed Maillard, Paola Morelli, John‐Paul Miroz, Eva Favre, Walid Sellami, Massimo Lamperti, Jamil Dibu, Richard Sivities, Angelos G. Kolias, Chris Thompson, Christopher Hawthorne, Justin Roberts, Lara Prisco, Roger Lightfoot, José I. Suárez, Luci Rivera-Lara, Susanne Muehlschlegel, Juan David Vega Padilla, Sanjeev Sivakumar, DaiWai M. Olson,
Uncertainties remain about the safety and efficacy of therapies for managing intracranial hypertension in acute brain injured (ABI) patients. This study aims to describe the therapeutical approaches used in ABI, with/without intracranial pressure (ICP) monitoring, among different pathologies and across different countries, and their association with six months mortality and neurological outcome.A preplanned subanalysis of the SYNAPSE-ICU study, a multicentre, prospective, international, observational ...
Tópico(s): Neurosurgical Procedures and Complications
2023 - Springer Science+Business Media | Intensive Care Medicine
Jun Zhong, Ashley Jermusyk, Lang Wu, Jason W. Hoskins, Irene Collins, Evelina Mocci, Mingfeng Zhang, Lei Song, Charles C. Chung, Tongwu Zhang, Wenming Xiao, Demetrius Albanes, Gabriella Andreotti, Alan A. Arslan, Ana Babić, William R. Bamlet, Laura E. Beane Freeman, Sonja Berndt, Ayelet Borgida, Paige M. Bracci, Lauren K. Brais, Paul Brennan, Bas Bueno‐de‐Mesquita, Julie E. Buring, Federico Canzian, Erica J. Childs, Michelle Cotterchio, Mengmeng Du, Eric J. Duell, Charles S. Fuchs, Steven Gallinger, J. Michael Gaziano, Graham G. Giles, Edward L. Giovannucci, Michael Goggins, Gary E. Goodman, Phyllis J. Goodman, Christopher Haiman, Patricia Hartge, Manal Hasan, Kathy J. Helzlsouer, Elizabeth A. Holly, Eric A. Klein, Manolis Kogevinas, Robert J. Kurtz, Loı̈c Le Marchand, Núria Malats, Satu Männistö, Roger L. Milne, Rachel Ε. Neale, Kimmie Ng, Ofure Obazee, Ann L. Oberg, Irene Orlow, Alpa V. Patel, Ulrike Peters, Miquel Porta, Nathaniel Rothman, Ghislaine Scélo, Howard D. Sesso, Gianluca Severi, Sabina Sieri, Debra T. Silverman, Malin Sund, Anne Tjønneland, Mark Thornquist, Geoffrey S. Tobias, Antonia Trichopoulou, Stephen K. Van Den Eeden, Kala Visvanathan, Jean Wactawski‐Wende, Nicolas Wentzensen, Emily White, Herbert Yu, Chen Yuan, Anne Zeleniuch‐Jacquotte, Robert N. Hoover, Kevin M. Brown, Charles Kooperberg, Harvey A. Risch, Eric J. Jacobs, Donghui Li, Kai Yu, Xiao‐Ou Shu, Stephen J. Chanock, Brian M. Wolpin, Rachael Z. Stolzenberg‐Solomon, Nilanjan Chatterjee, Alison P. Klein, Jill P. Smith, Peter Kraft, Jianxin Shi, Gloria M. Petersen, Wei Zheng, Laufey T. Ámundadóttir,
Abstract Background Although 20 pancreatic cancer susceptibility loci have been identified through genome-wide association studies in individuals of European ancestry, much of its heritability remains unexplained and the genes responsible largely unknown. Methods To discover novel pancreatic cancer risk loci and possible causal genes, we performed a pancreatic cancer transcriptome-wide association study in Europeans using three approaches: FUSION, MetaXcan, and Summary-MulTiXcan. We integrated genome- ...
Tópico(s): Genetic Syndromes and Imprinting
2019 - Oxford University Press | JNCI Journal of the National Cancer Institute
Produção Nacional
Revisado por pares
Elisa Danese, Sara Raimondi, Martina Montagnana, Angela Tagetti, Taimour Langaee, Paola Borgiani, Cinzia Ciccacci, Antonio J. Carcas, Alberto M. Borobia, Hoi Y. Tong, Cristina Lucía Dávila-Fajardo, Mariana Rodrigues Botton, Stéphane Bourgeois, Panos Deloukas, Michael D. Caldwell, J. K. Burmester, Richard L. Berg, Larisa H. Cavallari, Katarzyna Drozda, Min Huang, Lizi Zhao, Hanjing Cen, Rocío Gónzález‐Conejero, Vanessa Roldán, Yusuke Nakamura, Taisei Mushiroda, Inna Y. Gong, Richard B. Kim, Keita Hirai, Kunihiko Itoh, Carlos A. Arias, Leonardo Beltrán, Enrique Jiménez-Varo, Marisa Cañadas‐Garre, Alice Giontella, Marianne Kristiansen Kringen, Kari Bente Foss Haug, Hye Sun Gwak, Kyung Eun Lee, Pietro Minuz, Ming Ta Michael Lee, Steven A. Lubitz, Stuart A. Scott, Cristina Mazzaccara, Lucia Sacchetti, Ece Genç, Mahmut Özer, Anil Pathare, Rajagopal Krishnamoorthy, Andràs Páldi, Virginie Siguret, Marie‐Anne Loriot, Vijay Kumar Kutala, Guilherme Suarez‐Kurtz, Jamila Alessandra Perini, Joshua C. Denny, Andrea H. Ramirez, Balraj Mittal, Saurabh Singh Rathore, Hersh Sagreiya, Russ B. Altman, Mohamed H. Shahin, Sherief Khalifa, Nita A. Limdi, Charles Rivers, Aditi Shendre, Chrisly Dillon, Ivet Suriapranata, Honghao Zhou, Shenglan Tan, Vacis Tatarūnas, Vaiva Lesauskaitė, Yumao Zhang, Anke H. Maitland‐van der Zee, Talitha I. Verhoef, Anthonius de Boer, Monica Taljaard, Carlo–Federico Zambon, Vittorio Pengo, Jieying Eunice Zhang, Munir Pirmohamed, Julie A. Johnson, Cristiano Fava,
The cytochrome P450 ( CYP ) 4F2 gene is known to influence mean coumarin dose. The aim of the present study was to undertake a meta‐analysis at the individual patients level to capture the possible effect of ethnicity, gene—gene interaction, or other drugs on the association and to verify if inclusion of CYP 4F2*3 variant into dosing algorithms improves the prediction of mean coumarin dose. We asked the authors of our previous meta‐analysis (30 articles) and of 38 new articles retrieved by a systematic ...
Tópico(s): Analytical Methods in Pharmaceuticals
2018 - Wiley | Clinical Pharmacology & Therapeutics
Alison P. Klein, Brian M. Wolpin, Harvey A. Risch, Rachael Z. Stolzenberg‐Solomon, Evelina Mocci, Mingfeng Zhang, Federico Canzian, Erica J. Childs, Jason W. Hoskins, Ashley Jermusyk, Jun Zhong, Fei Chen, Demetrius Albanes, Gabriella Andreotti, Alan A. Arslan, Ana Babić, William R. Bamlet, Laura E. Beane Freeman, Sonja I. Berndt, Amanda L. Blackford, Michael Borges, Ayelet Borgida, Paige M. Bracci, Lauren K. Brais, Paul Brennan, Hermann Brenner, Bas Bueno‐de‐Mesquita, Julie E. Buring, Daniele Campa, Gabriele Capurso, Giulia Martina Cavestro, Kari G. Chaffee, Charles C. Chung, Sean P. Cleary, Michelle Cotterchio, Frederike Dijk, Eric J. Duell, Lenka Foretová, Charles S. Fuchs, Niccola Funel, Steven Gallinger, J. Michael Gaziano, Maria Gazouli, Graham G. Giles, Edward Giovannucci, Michael Goggins, Gary E. Goodman, Phyllis J. Goodman, Thilo Hackert, Christopher A. Haiman, Patricia Hartge, Manal Hasan, Péter Hegyi, Kathy J. Helzlsouer, Joseph M. Herman, Ivana Holcátová, Elizabeth A. Holly, Robert N. Hoover, Rayjean J. Hung, Eric J. Jacobs, Krzysztof Jamroziak, Vladimír Janout, Rudolf Kaaks, Kay‐Tee Khaw, Eric A. Klein, Manolis Kogevinas, Charles Kooperberg, Matthew H. Kulke, Juozas Kupčinskas, Robert J. Kurtz, Daniel A. Laheru, Stefano Landi, Rita T. Lawlor, I.-Min Lee, Loı̈c Le Marchand, Lingeng Lu, Núria Malats, Andrea Mambrini, Satu Männistö, Roger L. Milne, Beatrice Mohelníková-Duchoňová, Rachel Ε. Neale, John P. Neoptolemos, Ann L. Oberg, Sara H. Olson, Irene Orlow, Claudio Pasquali, Alpa V. Patel, Ulrike Peters, Raffaele Pezzilli, Miquel Porta, Francisco X. Real, Nathaniel Rothman, Ghislaine Scélo, Howard D. Sesso, Gianluca Severi, Xiao‐Ou Shu, Debra T. Silverman, Jill P. Smith, Pavel Souček, Malin Sund, Renata Talar‐Wojnarowska, Francesca Tavano, Mark Thornquist, Geoffrey S. Tobias, Stephen K. Van Den Eeden, Yogesh K. Vashist, Kala Visvanathan, Pavel Vodička, Jean Wactawski‐Wende, Zhaoming Wang, Nicolas Wentzensen, Emily White, Herbert Yu, Kai Yu, Anne Zeleniuch‐Jacquotte, Wei Zheng, Peter Kraft, Donghui Li, Stephen J. Chanock, Ofure Obazee, Gloria M. Petersen, Laufey T. Ámundadóttir,
In 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe and the United States combined. To identify common susceptibility alleles, we performed the largest pancreatic cancer GWAS to date, including 9040 patients and 12,496 controls of European ancestry from the Pancreatic Cancer Cohort Consortium (PanScan) and the Pancreatic Cancer Case-Control Consortium (PanC4). Here, we find significant evidence of a novel association at rs78417682 (7p12/TNS3, P = 4.35 × 10
Tópico(s): Cancer Genomics and Diagnostics
2018 - Nature Portfolio | Nature Communications
Jun Fang, Jinping Jia, Matthew Makowski, Mai Xu, Zhaoming Wang, Tongwu Zhang, Jason W. Hoskins, Jiyeon Choi, Younghun Han, Mingfeng Zhang, Janelle Thomas, Michael A. Kovacs, Irene Collins, Marta Dzyadyk, Abbey Thompson, Maura O’Neill, Sudipto Das, Qi Lan, Roelof Koster, Federico Canzian, Charles Kooperberg, Zhaoming Wang, Alan A. Arslan, Paige M. Bracci, Julie E. Buring, Eric J. Duell, Steven Gallinger, Eric J. Jacobs, Aruna Kamineni, Stephen Van Den Eeden, Alison P. Klein, Laurence N. Kolonel, Donghui Li, Sara H. Olson, Harvey A. Risch, Howard D. Sesso, Kala Visvanathan, Wei Zheng, Demetrius Albanes, Melissa A. Austin, Marie‐Christine Boutron‐Ruault, H. Bas Bueno‐de‐Mesquita, Michelle Cotterchio, J. Michael Gaziano, Edward L. Giovannucci, Michael Goggins, Myron D. Gross, Manal M. Hassan, Kathy J. Helzlsouer, Elizabeth A. Holly, David J. Hunter, Mazda Jenab, Rudolf Kaaks, Timothy J. Key, Kay‐Tee Khaw, Vittorio Krogh, Robert C. Kurtz, Andrea Z. LaCroix, Loı̈c Le Marchand, Satu Männistö, Alpa V. Patel, Petra H. Peeters, Elio Ríboli, Xiao-Ou Shu, Malin Sund, Mark Thornquist, Anne Tjønneland, Geoffrey S. Tobias, Dimitrios Trichopoulos, Jean Wactawski‐Wende, Herbert Yu, Kai Yu, Anne Zeleniuch‐Jacquotte, Robert N. Hoover, Patricia Hartge, Charles S. Fuchs, Stephen J. Chanock, Victoria L. Stevens, Demetrius Albanes, Neil E. Caporaso, Paul Brennan, James McKay, Xifeng Wu, Rayjean J. Hung, Esther M. John, Heike Bickeböller, Angela Risch, Erich Wichmann, Richard S. Houlston, Graham J. Mann, John L. Hopper, Joanne F. Aitken, Bruce K. Armstrong, Graham G. Giles, Elizabeth A. Holland, Richard Kefford, Anne Ε. Cust, Mark A. Jenkins, Helen Schmid, Susana Puig, Paula Aguilera, Célia Bádenas, Alicia Barreiro, Cristina Carrera, Daniel Gabriel, Pol Giménez‐Xavier, Pablo Iglesias-García, Josep Malvehy, Montserrat Milà, Ramón Pigem, Míriam Potrony, Joan Anton Puig-Batille, Gemma Tell‐Martí, Nicholas K. Hayward, Nicholas G. Martin, Grant W. Montgomery, David L. Duffy, David C. Whiteman, Stuart MacGregor, Donato Calista, Giorgi Landi, Paola Minghetti, Fabio Arcangeli, Pier Alberto Bertazzi, Paola Ghiorzo, Giovanna Bianchi‐Scarrà, Lorenza Pastorino, William Bruno, Virginia Andreotti, Paola Queirolo, Francesco Spagnolo, Rona M. MacKie, Julie Lang, Nelleke A. Gruis, Frans A. van Nieuwpoort, Coby Out, Wilma Bergman, Nicole A. Kukutsch, Jan Nico Bouwes Bavinck, Egbert Bakker, Nienke van der Stoep, Jeanet ter Huurne, Han van der Rhee, Marcel W. Bekkenk, Dyon Snels, Marinus van Praag, Liève Brochez, Rianne M. J. P. Gerritsen, Marianne B. Crijns, Hans F. A. Vasen, Bart Janssen, Christian Ingvar, Håkan Olsson, Göran Jönsson, Åke Borg, Katja Harbst, K. Nielsen, Anita Schmidt Zander, Anders Molvern, Per Helsing, Per Arne Andresen, Helge Rootwelt, Lars A. Akslen, Brigitte Bressac–de Paillerets, Florence Démenais, Marie‐Françoise Avril, Valérie Chaudru, Patricia Jeannin, Fabienne Lesueur, E. Maubec, Hamida Mohamdi, M.J. Bossard, Amaury Vaysse, F. Boitier, Olivier Caron, F. Caux, Stéphane Dalle, O. Dereure, Dominique Leroux, Ludovic Martin, Christine Matéus, Caroline Robert, Dominique Stoppa‐Lyonnet, L. Thomas, E. Wierzbicka, David E. Elder, Michael E. Ming, Nandita Mitra, Tadeusz Dębniak, Jan Lubiński, Marko Hočevar, Srdjan Novaković, Barbara Perić, Petra Škerl, Johan Hansson, Veronica Höiom, Eitan Freidman, Esther Azizi, Orna Baron‐Epel, Alon Scope, Felix Pavlotsky, Irit Cohen‐Manheim, Yael Laitman, Mark Harland, Juliette A. Randerson‐Moor, Jon Laye, John Dwyfor Davies, Jérémie Nsengimana, Sally J. O’Shea, May Chan, Jo Gascoyne, Margaret A. Tucker, Alisa M. Goldstein, Xiaohong R. Yang, Rachael S. Stolzenberg-Solomon, Peter Kraft, Brian M. Wolpin, Pascal W.T.C. Jansen, Sara H. Olson, Katherine A. McGlynn, Peter A. Kanetsky, Nilanjan Chatterjee, Jennifer H. Barrett, Alison M. Dunning, John Taylor, Julia Newton‐Bishop, D. Timothy Bishop, Þorkell Andrésson, Gloria M. Petersen, Christopher I. Amos, Mark M. Iles, Katherine L. Nathanson, Maria Teresa Landi, Michiel Vermeulen, Kevin M. Brown, Laufey T. Ámundadóttir,
Abstract Genome wide association studies (GWAS) have mapped multiple independent cancer susceptibility loci to chr5p15.33. Here, we show that fine-mapping of pancreatic and testicular cancer GWAS within one of these loci (Region 2 in CLPTM1L ) focuses the signal to nine highly correlated SNPs. Of these, rs36115365-C associated with increased pancreatic and testicular but decreased lung cancer and melanoma risk, and exhibited preferred protein-binding and enhanced regulatory activity. Transcriptional ...
Tópico(s): Chromosomal and Genetic Variations
2017 - Nature Portfolio | Nature Communications
Mitchell J. Machiela, Weiyin Zhou, Eric Karlins, Joshua N. Sampson, Neal D. Freedman, Qi Yang, Belynda Hicks, Casey Dagnall, Christopher Hautman, Kevin B. Jacobs, Christian C. Abnet, Melinda C. Aldrich, Christopher I. Amos, Laufey T. Ámundadóttir, Alan A. Arslan, Laura E. Beane Freeman, Sonja I. Berndt, Amanda Black, William J. Blot, Cathryn H. Bock, Paige M. Bracci, Louise A. Brinton, H. Bas Bueno‐de‐Mesquita, Laurie Burdett, Julie E. Buring, Mary Ann Butler, Federico Canzian, Tania Carreón, Kari G. Chaffee, I‐Shou Chang, Nilanjan Chatterjee, Chu Chen, Constance Chen, Kexin Chen, Charles C. Chung, Linda S. Cook, Marta Crous‐Bou, Michael Cullen, Faith G. Davis, Immaculata De Vivo, Ti Ding, Jennifer A. Doherty, Eric J. Duell, Caroline G. Epstein, Jin‐Hu Fan, Jonine D. Figueroa, Joseph F. Fraumeni, Christine M. Friedenreich, Charles S. Fuchs, Steven Gallinger, Yu‐Tang Gao, Susan M. Gapstur, Montserrat García‐Closas, Mia M. Gaudet, J. Michael Gaziano, Graham G. Giles, Elizabeth M. Gillanders, Edward L. Giovannucci, Lynn R. Goldin, Alisa M. Goldstein, Christopher A. Haiman, Göran Hallmans, Susan E. Hankinson, Curtis C. Harris, Roger Henriksson, Elizabeth A. Holly, Yun‐Chul Hong, Robert N. Hoover, Chao A. Hsiung, Nan Hu, Wei Hu, David J. Hunter, Amy Hutchinson, Mazda Jenab, Christoffer Johansen, Kay‐Tee Khaw, Hee Nam Kim, Yeul Hong Kim, Young Tae Kim, Alison P. Klein, Robert J. Klein, Woon‐Puay Koh, Laurence N. Kolonel, Charles Kooperberg, Peter Kraft, Vittorio Krogh, Robert C. Kurtz, Andrea Z. LaCroix, Qing Lan, Maria Teresa Landi, Loı̈c Le Marchand, Donghui Li, Xiaolin Liang, Linda M. Liao, Dongxin Lin, Jianjun Liu, Jolanta Lissowska, Lingeng Lu, Anthony Magliocco, Núria Malats, Keitaro Matsuo, Lorna H. McNeill, Robert R. McWilliams, Beatrice Melin, Kari G. Rabe, Lee E. Moore, Sara H. Olson, Irene Orlow, Jae Yong Park, Ana Patiño‐García, Beata Pepłońska, Ulrike Peters, Gloria M. Petersen, Loreall Pooler, Jennifer Prescott, Ludmila Prokunina‐Olsson, Mark P. Purdue, You‐Lin Qiao, Preetha Rajaraman, Francisco X. Real, Elio Ríboli, Harvey A. Risch, Benjamín Rodríguez‐Santiago, Avima M. Ruder, Sharon A. Savage, Fredrick R. Schumacher, Ann G. Schwartz, Kendra Schwartz, Adeline Seow, Veronica Wendy Setiawan, Gianluca Severi, Hongbing Shen, Xin Sheng, Min‐Ho Shin, Xiao‐Ou Shu, Debra T. Silverman, Margaret R. Spitz, Victoria L. Stevens, Rachael Z. Stolzenberg‐Solomon, Daniel O. Stram, Ze‐Zhong Tang, Philip R. Taylor, Lauren R. Teras, Geoffrey S. Tobias, David Van Den Berg, Kala Visvanathan, Sholom Wacholder, Jiucun Wang, Zhaoming Wang, Nicolas Wentzensen, William Wheeler, Emily White, John K. Wiencke, Brian M. Wolpin, Maria Pik Wong, Chen Wu, Tangchun Wu, Xifeng Wu, Yi‐Long Wu, Jay S. Wunder, Lucy Xia, Hannah Yang, Pan‐Chyr Yang, Kai Yu, Krista A. Zanetti, Anne Zeleniuch‐Jacquotte, Wei Zheng, Baosen Zhou, Regina G. Ziegler, Luis A. Pérez‐Jurado, Neil E. Caporaso, Nathaniel Rothman, Margaret A. Tucker, Michael Dean, Meredith Yeager, Stephen J. Chanock,
Abstract To investigate large structural clonal mosaicism of chromosome X, we analysed the SNP microarray intensity data of 38,303 women from cancer genome-wide association studies (20,878 cases and 17,425 controls) and detected 124 mosaic X events >2 Mb in 97 (0.25%) women. Here we show rates for X-chromosome mosaicism are four times higher than mean autosomal rates; X mosaic events more often include the entire chromosome and participants with X events more likely harbour autosomal mosaic events. ...
Tópico(s): Genomics and Chromatin Dynamics
2016 - Nature Portfolio | Nature Communications
Joshua N. Sampson, William A. Wheeler, Meredith Yeager, Orestis A. Panagiotou, Zhaoming Wang, Sonja I. Berndt, Qing Lan, Christian C. Abnet, Laufey T. Ámundadóttir, Jonine D. Figueroa, Maria Teresa Landi, Kari G. Rabe, Sharon A. Savage, Philip R. Taylor, Immaculata De Vivo, Katherine A. McGlynn, Mark P. Purdue, Preetha Rajaraman, Hans‐Olov Adami, Anders Ahlbom, Demetrius Albanes, Maria Fernanda Amary, She-Juan An, Ulrika Andersson, Gerald L. Andriole, Irene L. Andrulis, Emanuele Angelucci, Stephen M. Ansell, Cecilia Arici, Bruce K. Armstrong, Alan A. Arslan, Melissa A. Austin, Dalsu Baris, Donald A. Barkauskas, Bryan A. Bassig, Nikolaus Becker, Yolanda Benavente, Simone Benhamou, Christine D. Berg, David Van Den Berg, Leslie Bernstein, Kimberly A. Bertrand, Brenda M. Birmann, Amanda Black, Heiner Boeing, Paolo Boffetta, Marie‐Christine Boutron‐Ruault, Paige M. Bracci, Louise A. Brinton, Angela Brooks‐Wilson, H. Bas Bueno‐de‐Mesquita, Laurie Burdett, Julie E. Buring, Mary Ann Butler, Qiuyin Cai, Géraldine Cancel‐Tassin, Federico Canzian, Alfredo Carrato, Tania Carreón, Angela Carta, John K. Chan, Ellen T. Chang, Gee‐Chen Chang, I‐Shou Chang, Jiang Chang, Jenny Chang‐Claude, Chien‐Jen Chen, Chih-Yi Chen, Chu Chen, Chung‐Hsing Chen, Constance Chen, Hongyan Chen, Kexin Chen, Kuan‐Yu Chen, Kun‐Chieh Chen, Ying Chen, Ying-Hsiang Chen, Yi-Song Chen, Yuh-Min Chen, Li-Hsin Chien, María‐Dolores Chirlaque, Jin Eun Choi, Yi Young Choi, Wong‐Ho Chow, Charles C. Chung, Jacqueline Clavel, Françoise Clavel‐Chapelon, Pierluigi Cocco, Joanne S. Colt, Éva Compérat, Lucía Conde, Joseph M. Connors, David V. Conti, Victoria K. Cortessis, Michelle Cotterchio, Wendy Cozen, Simon Crouch, Marta Crous‐Bou, Olivier Cussenot, Faith G. Davis, Ti Ding, W. Ryan Diver, Miren Dorronsoro, Laure Dossus, Eric J. Duell, Maria Grazia Ennas, Ralph L. Erickson, Maria Feychting, Adrienne M. Flanagan, Lenka Foretová, Joseph F. Fraumeni, Neal D. Freedman, Laura E. Beane Freeman, Charles S. Fuchs, Manuela Gago‐Dominguez, Steven Gallinger, Yu-Tang Gao, Susan M. Gapstur, Montserrat García‐Closas, Reina García-Closas, Randy D. Gascoyne, Julie M. Gastier‐Foster, Mia M. Gaudet, J. Michael Gaziano, Carol Giffen, Graham G. Giles, Edward Giovannucci, Bengt Glimelius, Michael Goggins, Nalan Gökgöz, Alisa M. Goldstein, Richard Görlick, Myron D. Gross, Robert L. Grubb, Jian Gu, Peng Guan, Marc J. Gunter, Huan Guo, Thomas M. Habermann, Christopher A. Haiman, Dina Halai, Göran Hallmans, Manal M. Hassan, Claudia Maria Hattinger, Qincheng He, Xingzhou He, Kathy J. Helzlsouer, Brian E. Henderson, Roger Henriksson, Henrik Hjalgrim, Judith Hoffman–Bolton, Chancellor Hohensee, Theodore R. Holford, Elizabeth A. Holly, Yun‐Chul Hong, Robert N. Hoover, Pamela L. Horn‐Ross, GM Monawar Hosain, H. Dean Hosgood, Chin‐Fu Hsiao, Nan Hu, Wei Hu, Zhibin Hu, Ming-Shyan Huang, José María Huerta, Jen‐Yu Hung, Amy Hutchinson, Peter D. Inskip, Rebecca D. Jackson, Eric J. Jacobs, Mazda Jenab, Hyo-Sung Jeon, Bu-Tian Ji, Guangfu Jin, Jin Li, Christoffer Johansen, Alison Johnson, Yoo Jin Jung, Rudolph Kaaks, Aruna Kamineni, Eleanor Kane, Chang Hyun Kang, Margaret R. Karagas, Rachel S. Kelly, Kay‐Tee Khaw, Christopher Kim, Hee Nam Kim, Jin Hee Kim, Jun Suk Kim, Yeul Hong Kim, Young Tae Kim, Young‐Chul Kim, Cari M. Kitahara, Alison P. Klein, Robert J. Klein, Manolis Kogevinas, Takashi Kohno, Laurence N. Kolonel, Charles Kooperberg, Anne Kricker, Vittorio Krogh, Hideo Kunitoh, Robert C. Kurtz, Sun‐Seog Kweon, Andrea LaCroix, Charles Lawrence, Fernando Lecanda, Victor Lee, Donghui Li, Haixin Li, Jihua Li, Yao-Jen Li, Yuqing Li, Linda M. Liao, Mark Liebow, Tracy Lightfoot, Wei-Yen Lim, Chien‐Chung Lin, Dongxin Lin, Sara Lindstrӧm, Martha S. Linet, Brian K. Link, Chenwei Liu, Jianjun Liu, Li Liu, Börje Ljungberg, Josep Lloreta, Simonetta Di Lollo, Daru Lu, Eiliv Lund, Núria Malats, Satu Männistö, Loı̈c Le Marchand, Neyssa Marina, Giovanna Masala, Giuseppe Mastrangelo, Keitaro Matsuo, Marc Maynadié, James McKay, Roberta McKean‐Cowdin, Mads Melbye, Beatrice Melin, Dominique S. Michaud, Tetsuya Mitsudomi, Alain Monnereau, Rebecca Montalvan, Lee E. Moore, Lotte Maxild Mortensen, Alexandra Nieters, Kari E. North, Anne J. Novak, Ann L. Oberg, Kenneth Offit, In‐Jae Oh, Sara H. Olson, Domenico Palli, William Pao, In Kyu Park, Jae Yong Park, Kyong Hwa Park, Ana Patiño‐García, Sofia Pavanello, Petra H. Peeters, Reury-Perng Perng, Ulrike Peters, Gloria M. Petersen, Piero Picci, Malcolm C. Pike, Stefano Porru, Jennifer Prescott, Ludmila Prokunina‐Olsson, Biyun Qian, You‐Lin Qiao, Marco Rais, Elio Ríboli, Jacques Riby, Harvey A. Risch, Cosmeri Rizzato, Rebecca J. Rodabough, Eve Roman, Morgan Rouprêt, Avima M. Ruder, Sílvia de Sanjosé, Ghislaine Scélo, Alan R. Schned, Fredrick R. Schumacher, Kendra Schwartz, Molly Schwenn, Katia Scotlandi, Adeline Seow, Cònsol Serra, Massimo Serra, Howard D. Sesso, Veronica Wendy Setiawan, Gianluca Severi, Richard K. Severson,
Studies of related individuals have consistently demonstrated notable familial aggregation of cancer. We aim to estimate the heritability and genetic correlation attributable to the additive effects of common single-nucleotide polymorphisms (SNPs) for cancer at 13 anatomical sites.
Oxford University Press