Shelley R. Hepworth, Federico Valverde, Dean Ravenscroft, Aidyn Mouradov, George Coupland,
... Search for more papers by this author Federico Valverde Federico Valverde John Innes Centre, Colney Lane, Norwich, NR4 ... Search for more papers by this author Federico Valverde Federico Valverde John Innes Centre, Colney Lane, Norwich, NR4 7UH ...
Tópico(s): Plant Reproductive Biology
2002 - Springer Nature | The EMBO Journal
Seonghoe Jang, Virginie Marchal, Kishore C. S. Panigrahi, Stephan Wenkel, Wim J. J. Soppe, Xing‐Wang Deng, Federico Valverde, George Coupland,
... Search for more papers by this author Federico Valverde Federico Valverde Instituto de Bioquímica Vegetal y Fotosíntesis, CSIC, ... Search for more papers by this author Federico Valverde Federico Valverde Instituto de Bioquímica Vegetal y Fotosíntesis, CSIC, Universidad ...
Tópico(s): Photosynthetic Processes and Mechanisms
2008 - Springer Nature | The EMBO Journal
Produção Nacional
Revisado por pares
J. Romero, Gloria Serrano, Carolina Camacho‐Fernández, Mateus Henrique Vicente, María Teresa Gil Ruiz, José R. Pérez‐Castiñeira, Javier Pérez-Hormaeche, Fábio Tebaldi Silveira Nogueira, Federico Valverde,
Abstract How does a plant detect the changing seasons and make important developmental decisions accordingly? How do they incorporate daylength information into their routine physiological processes? Photoperiodism, or the capacity to measure the daylength, is a crucial aspect of plant development that helps plants determine the best time of the year to make vital decisions, such as flowering. The protein CONSTANS (CO) constitutes the central regulator of this sensing mechanism, not only activating ...
Tópico(s): Photosynthetic Processes and Mechanisms
2024 - Oxford University Press | The Plant Cell
Produção Nacional
Revisado por pares
Jean‐Yves Blay, Emanuela Palmerini, Julien Bollard, Samuel Aguiar, Martín Ángel, B. Araya, R. Badilla, Daniel Bernabéu, Fernando Augusto Batista Campos, Chs Caro-Sánchez, A. Carvajal Montoya, Sandro Casavilca‐Zambrano, Victor Castro Oliden, Matías Chacón, M A Clara-Altamirano, Paola Collini, R. Correa Genoroso, Felipe D’Almeida Costa, M. Cuellar, Angelo Paolo Dei Tos, HR Dominguez Malagon, DM Donati, Armelle Dufresne, Mikael Eriksson, M. Farias-Loza, AM Frezza, Tommaso Frisoni, Dorian Yarih García-Ortega, H. Gerderblom, F. Gouin, M. Carmen Gómez-Mateo, Alessandro Gronchi, Juan C Haro, Nadia Hindi, Lourdes Huanca, Natàlia Jiménez, Marie Karanian, Bernd Kasper, Ademar Lopes, BB Lopes David, Antonio López‐Pousa, Georg Lutter, Robert G. Maki, Héctor Martínez‐Said, JL Martinez-Tlahuel, Celso Abdon Lopes de Mello, J. M. Morales Pérez, David S. Moura, Suely Akiko Nakagawa, Antonio G. Nascimento, EJ Ortiz-Cruz, Shreyaskumar Patel, Yanina Pflüger, Salvatore Provenzano, Alberto Righi, A. Rodriguez, T.T.G. Santos, Katia Scotlandi, Silva Mlg, Tomás Soulé, Silvia Stacchiotti, CM Valverde, Federico Waisberg, E. Zamora Estrada, Javier Martín‐Broto,
Bone sarcoma are infrequent diseases, representing < 0.2% of all adult neoplasms. A multidisciplinary management within reference centers for sarcoma, with discussion of the diagnostic and therapeutic strategies within an expert multidisciplinary tumour board, is essential for these patients, given its heterogeneity and low frequency. This approach leads to an improvement in patient's outcome, as demonstrated in several studies. The Sarcoma European Latin-American Network (SELNET), aims to improve ...
Tópico(s): Cancer Diagnosis and Treatment
2022 - Elsevier BV | Critical Reviews in Oncology/Hematology
Produção Nacional
Revisado por pares
Jean‐Yves Blay, Nadia Hindi, Julien Bollard, Samuel Aguiar, Martín Ángel, B. Araya, R. Badilla, Daniel Bernabéu, Fernando Augusto Batista Campos, C H S Caro-Sánchez, B. Carvajal, A. Carvajal Montoya, Sandro Casavilca‐Zambrano, Victor Castro Oliden, Matías Chacón, Martin Clara, Paola Collini, R. Correa Genoroso, Felipe D’Almeida Costa, M J Cuéllar, Angelo Paolo Dei Tos, Hugo Ricardo Domínguez Malagón, Davide María Donati, Armelle Dufresne, Mikael Eriksson, M. Farias-Loza, Piga Fernández, Anna Maria Frezza, Tommaso Frisoni, Dorian Yarih García-Ortega, Hans Gelderblom, F. Gouin, M. Carmen Gómez-Mateo, Alessandro Gronchi, Juan C Haro, Lourdes Huanca, N. V. Jiménez, Marie Karanian, Bernd Kasper, Bruna Bianca Lopes David, Antonio López‐Pousa, Georg Lutter, Héctor Martínez‐Said, Jorge Luis Martínez-Tláhuel, Celso Abdon Lopes de Mello, J. M. Morales Pérez, David S. Moura, Antonio G. Nascimento, Eduardo Ortiz-Cruz, Emanuela Palmerini, Shreyaskumar Patel, Yanina Pflüger, Salvatore Provenzano, Alberto Righi, A. Rodriguez, Rodrigo Salas, T.T.G. Santos, Katia Scotlandi, Tomás Soulé, Silvia Stacchiotti, Claudia Valverde, Federico Waisberg, E. Zamora Estrada, Javier Martín‐Broto,
•Soft tissue sarcoma (STS) and gastrointestinal tumors (GIST) encompass > 80 different histologic subtypes.•Clinical practice guidelines for STS and GIST still lack in Latin-American countries.•Tailored clinical guidelines are instrumental to improve outcome in sarcoma patients in LatinAmerican countries.•This is the first review establishing STS and GIST guidelines for the purpose of LatinAmerican clinical practices to our knowledge.
Tópico(s): Soft tissue tumors and treatment
2021 - Elsevier BV | Cancer Treatment Reviews
Marta Cruces‐Sande, Rocío Vila‐Bedmar, Alba C. Arcones, Águeda González‐Rodríguez, Patricia Rada, Virginia Gutiérrez-de-Juan, Javier Vargas‐Castrillón, Paula Iruzubieta, Cristina Sánchez‐González, Laura Formentini, Javier Crespo, Carmelo Garcı́a-Monzón, María Luz Martínez‐Chantar, Ángela M. Valverde, Federico Mayor, Cristina Murga,
Insulin resistance (IR) and obesity are important risk factors for non-alcoholic fatty liver disease (NAFLD). G protein-coupled receptor kinase 2 (GRK2) is involved in the development of IR and obesity in vivo. However, its possible contribution to NAFLD and/or non-alcoholic steatohepatitis (NASH) independently of its role on IR or fat mass accretion has not been explored. Here, we used wild-type (WT) or GRK2 hemizygous (GRK2±) mice fed a high-fat diet (HFD) or a methionine and choline-deficient diet (MCD) ...
Tópico(s): Endoplasmic Reticulum Stress and Disease
2018 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Elysia Alvarez, Midori Seppa, Silvia Rivas, Lucía Fuentes, Patricia Valverde, Federico Antillón‐Klussmann, Mauricio Castellanos, E. Alejandro Sweet‐Cordero, Kevin Messacar, John Kurap, Marisol Bustamante, Scott C. Howard, Bradley Efron, Sandra Luna‐Fineman,
Treatment refusal and abandonment are major causes of treatment failure for children with cancer in low- and middle-income countries (LMICs), like Guatemala. This study identified risk factors for and described the intervention that decreased abandonment.This was a retrospective study of Guatemalan children (0-18 years) with cancer treated at the Unidad Nacional de Oncología Pediátrica (UNOP), 2001-2008, using the Pediatric Oncology Network Database. Treatment refusal was a failure to begin treatment ...
Tópico(s): Ethics and Legal Issues in Pediatric Healthcare
2017 - Wiley | Pediatric Blood & Cancer
Luís Fernández, Julián Nevado, Fernando Santos, Damián Heine‐Suñer, Victor Martínez‐Glez, Sixto García‐Miñaúr, R. Garrido Palomo, Alicia Delicado, I. López Pajares, María Palomares‐Bralo, Luis García‐Guereta, Eva Valverde, Federico Hawkins, Pablo Lapunzina,
Individuals affected with DiGeorge and Velocardiofacial syndromes present with both phenotypic diversity and variable expressivity. The most frequent clinical features include conotruncal congenital heart defects, velopharyngeal insufficiency, hypocalcemia and a characteristic craniofacial dysmorphism. The etiology in most patients is a 3 Mb recurrent deletion in region 22q11.2. However, cases of infrequent deletions and duplications with different sizes and locations have also been reported, generally ...
Tópico(s): Tracheal and airway disorders
2009 - BioMed Central | BMC Medical Genetics
... Cely-Ortiz A, Felice J, Díaz-Zegarra L, Valverde C, Federico M, Palomeque J, Wehrens X, Kranias E, Aiello ...
Tópico(s): Ion channel regulation and function
1977 - Lippincott Williams & Wilkins | Circulation Research
Hee Jin Park, Francisco M. Gámez‐Arjona, Marika Lindahl, Rashid Aman, Irène Villalta, Joon‐Yung Cha, Raúl Carranco, Chae Jin Lim, Elena González, Ray A. Bressan, Sang Yeol Lee, Federico Valverde, Clara Sánchez‐Rodríguez, José M. Pardo, Woe‐Yeon Kim, Francisco J. Quintero, Dae‐Jin Yun,
Abstract The precise timing of flowering in adverse environments is critical for plants to secure reproductive success. We report a mechanism in Arabidopsis (Arabidopsis thaliana) controlling the time of flowering by which the S-acylation-dependent nuclear import of the protein SALT OVERLY SENSITIVE3/CALCINEURIN B-LIKE4 (SOS3/CBL4), a Ca2+-signaling intermediary in the plant response to salinity, results in the selective stabilization of the flowering time regulator GIGANTEA inside the nucleus under ...
Tópico(s): Plant Stress Responses and Tolerance
2022 - Oxford University Press | The Plant Cell
Gloria Serrano, Pedro de los Reyes, Andrea Chini, Gabriel Ferreras-Garrucho, Víctor Sánchez de Medina-Hernández, Marta Botër, Roberto Solano, Federico Valverde,
In Arabidopsis, photoperiodic flowering is controlled by the regulatory hub gene CONSTANS (CO), whereas floral organ senescence is regulated by the jasmonates (JAs). Because these processes are chronologically ordered, it remains unknown whether there are common regulators of both processes. In this study, we discovered that CO protein accumulates in Arabidopsis flowers after floral induction, and it displays a diurnal pattern in floral organs different from that in the leaves. We observed that altered ...
Tópico(s): Photosynthetic Processes and Mechanisms
2022 - Elsevier BV | Molecular Plant
Gloria Serrano, Víctor Sánchez de Medina Hernández, Federico Valverde,
The length of the day (photoperiod) is a robust seasonal signal originated by earth orbital and translational movements, a resilient external cue to the global climate change, and a predictable hint to initiate or complete different developmental programs. In eukaryotic algae, the gene expression network that controls the cellular response to photoperiod also regulates other basic physiological functions such as starch synthesis or redox homeostasis. Land plants, evolving in a novel and demanding ...
Tópico(s): Photosynthetic Processes and Mechanisms
2021 - Frontiers Media | Frontiers in Plant Science
Gloria Serrano, Fatima E. Said, Pedro de los Reyes, Eva Lucas-Reina, M. Isabel Ortiz‐Marchena, J. Romero, Federico Valverde,
Summary Flowering time is a key process in plant development. Photoperiodic signals play a crucial role in the floral transition in Arabidopsis thaliana , and the protein CONSTANS (CO) has a central regulatory function that is tightly regulated at the transcriptional and post‐translational levels. The stability of CO protein depends on a light‐driven proteasome process that optimizes its accumulation in the evening to promote the production of the florigen FLOWERING LOCUS T (FT) and induce seasonal ...
Tópico(s): Plant Stress Responses and Tolerance
2019 - Wiley | The Plant Journal
Ryosuke Hayama, Peizhen Yang, Federico Valverde, Tsuyoshi Mizoguchi, Ikuyo Furutani-Hayama, Richard D. Vierstra, George Coupland,
Abstract Protein ubiquitylation participates in a number of essential cellular processes including signal transduction and transcription, often by initiating the degradation of specific substrates through the 26S proteasome. Within the ubiquitin-proteasome system, deubiquitylating enzymes (DUBs) not only help generate and maintain the supply of free ubiquitin monomers, they also directly control functions and activities of specific target proteins by modulating the pool of ubiquitylated species. ...
Tópico(s): Photosynthetic Processes and Mechanisms
2019 - Nature Portfolio | Scientific Reports
Gloria Serrano, Francisco J. Romero‐Campero, Eva Lucas-Reina, J. Romero, Federico Valverde,
Measuring day length confers a strong fitness improvement to photosynthetic organisms as it allows them to anticipate light phases and take the best decisions preceding diurnal transitions. In close association with signals from the circadian clock and the photoreceptors, photoperiodic sensing constitutes also a precise way to determine the passing of the seasons and to take annual decisions such as the best time to flower or the beginning of dormancy. Photoperiodic sensing in photosynthetic organisms ...
Tópico(s): Photosynthetic Processes and Mechanisms
2017 - Elsevier BV | Current Opinion in Plant Biology
Asier Briones‐Moreno, Jorge Hernández‐García, Carlos Vargas-Chávez, Francisco J. Romero‐Campero, J. Romero, Federico Valverde, Miguel Á. Blázquez,
DELLA proteins are transcriptional regulators present in all land plants which have been shown to modulate the activity of over 100 transcription factors in Arabidopsis, involved in multiple physiological and developmental processes. It has been proposed that DELLAs transduce environmental information to pre-wired transcriptional circuits because their stability is regulated by gibberellins (GAs), whose homeostasis largely depends on environmental signals. The ability of GAs to promote DELLA degradation ...
Tópico(s): Microbial Metabolic Engineering and Bioproduction
2017 - Frontiers Media | Frontiers in Plant Science
Pedro de los Reyes, Francisco J. Romero‐Campero, María Teresa Gil Ruiz, J. Romero, Federico Valverde,
Daily rhythms play a key role in transcriptome regulation in plants and microalgae orchestrating responses that, among other processes, anticipate light transitions that are essential for their metabolism and development. The recent accumulation of genome-wide transcriptomic data generated under alternating light:dark periods from plants and microalgae has made possible integrative and comparative analysis that could contribute to shed light on the evolution of daily rhythms in the green lineage. ...
Tópico(s): Microbial Metabolic Engineering and Bioproduction
2017 - Frontiers Media | Frontiers in Plant Science
T. Albi, María Teresa Gil Ruiz, Pedro de los Reyes, Federico Valverde, J. Romero,
Sucrose-phosphate phosphatase (SPP) catalyses the final step in the sucrose biosynthesis pathway. Arabidopsis thaliana genome codifies four SPP isoforms. In this study, the four Arabidopsis thaliana genes coding for SPP isoforms have been cloned, expressed in Escherichia coli and the kinetic and regulatory properties of the purified enzymes analysed. SPP2 is the isoform showing the highest activity, with SPP3b and SPP3a showing lower activity levels. No activity was detected for SPP1. We propose ...
Tópico(s): Photosynthetic Processes and Mechanisms
2016 - Public Library of Science | PLoS ONE
Francisco J. Romero‐Campero, Ignacio Pérez–Hurtado, Eva Lucas-Reina, J. Romero, Federico Valverde,
Chlamydomonas reinhardtii is the model organism that serves as a reference for studies in algal genomics and physiology. It is of special interest in the study of the evolution of regulatory pathways from algae to higher plants. Additionally, it has recently gained attention as a potential source for bio-fuel and bio-hydrogen production. The genome of Chlamydomonas is available, facilitating the analysis of its transcriptome by RNA-seq data. This has produced a massive amount of data that remains ...
Tópico(s): Gene Regulatory Network Analysis
2016 - BioMed Central | BMC Genomics
Federico Valverde, Francisco J. Romero‐Campero, Rosa León, Miguel G. Guerrero, Aurelio Serrano,
Photosynthetic protists, also called microalgae, have been systematically studied for more than a century. However, only recently broad biotechnological applications have fostered a novel wave of research on their potentialities as sustainable resources of renewable energy as well as valuable industrial and agro-food products. At the recent VII European Congress of Protistology held in Seville, three outstanding examples of different research strategies on microalgae with biotechnological implications ...
Tópico(s): Photosynthetic Processes and Mechanisms
2016 - Elsevier BV | European Journal of Protistology
Eva Lucas-Reina, Francisco J. Romero‐Campero, J. Romero, Federico Valverde,
The response to daylength is a crucial process that evolved very early in plant evolution, entitling the early green eukaryote to predict seasonal variability and attune its physiological responses to the environment. The photoperiod responses evolved into the complex signaling pathways that govern the angiosperm floral transition today. The Chlamydomonas reinhardtii DNA-Binding with One Finger (CrDOF) gene controls transcription in a photoperiod-dependent manner, and its misexpression influences ...
Tópico(s): Light effects on plants
2015 - Oxford University Press | PLANT PHYSIOLOGY
M. Isabel Ortiz‐Marchena, J. Romero, Federico Valverde,
Florigen is a mobile signal released by the leaves that reaching the shoot apical meristem (SAM), changes its developmental program from vegetative to reproductive. The protein FLOWERING LOCUS T (FT) constitutes an important element of the florigen, but other components such as sugars, have been also proposed to be part of this signal.Citation1-5 We have studied the accumulation and composition of starch during the floral transition in Arabidopsis thaliana in order to understand the role of carbon ...
Tópico(s): Plant Reproductive Biology
2015 - Taylor & Francis | Plant Signaling & Behavior
Liron Sarid‐Krebs, Kishore C. S. Panigrahi, Fabio Fornara, Yasuyuki Takahashi, Ryosuke Hayama, Seonghoe Jang, Vicky Tilmes, Federico Valverde, George Coupland,
Seasonal flowering involves responses to changes in day length. In Arabidopsis thaliana, the CONSTANS (CO) transcription factor promotes flowering in the long days of spring and summer. Late flowering in short days is due to instability of CO, which is efficiently ubiquitinated in the dark by the CONSTITUTIVE PHOTOMORPHOGENIC 1 (COP1) E3 ligase complex. Here we show that CO is also phosphorylated. Phosphorylated and unphosphorylated forms are detected throughout the diurnal cycle but their ratio varies, ...
Tópico(s): Photosynthetic Processes and Mechanisms
2015 - Wiley | The Plant Journal
M. Isabel Ortiz‐Marchena, T. Albi, Eva Lucas-Reina, Fatima E. Said, Francisco J. Romero‐Campero, Beatriz Cano, María Teresa Gil Ruiz, J. Romero, Federico Valverde,
Abstract Flowering is a crucial process that demands substantial resources. Carbon metabolism must be coordinated with development through a control mechanism that optimizes fitness for any physiological need and growth stage of the plant. However, how sugar allocation is controlled during the floral transition is unknown. Recently, the role of a CONSTANS (CO) ortholog (Cr-CO) in the control of the photoperiod response in the green alga Chlamydomonas reinhardtii and its influence on starch metabolism ...
Tópico(s): Light effects on plants
2014 - Oxford University Press | The Plant Cell
Francisco J. Romero‐Campero, Eva Lucas-Reina, Fatima E. Said, J. Romero, Federico Valverde,
Phototrophic eukaryotes are among the most successful organisms on Earth due to their unparalleled efficiency at capturing light energy and fixing carbon dioxide to produce organic molecules. A conserved and efficient network of light-dependent regulatory modules could be at the bases of this success. This regulatory system conferred early advantages to phototrophic eukaryotes that allowed for specialization, complex developmental processes and modern plant characteristics. We have studied light- ...
Tópico(s): Microbial Community Ecology and Physiology
2013 - Frontiers Media | Frontiers in Plant Science
A. M. Lázaro, Federico Valverde, Manuel Piñeiro, José A. Jarillo,
The Arabidopsis thaliana early in short days6 (esd6) mutant was isolated in a screen for mutations that accelerate flowering time. Among other developmental alterations, esd6 displays early flowering in both long- and short-day conditions. Fine mapping of the mutation showed that the esd6 phenotype is caused by a lesion in the high expression of osmotically responsive genes1 (HOS1) locus, which encodes a RING finger-containing E3 ubiquitin ligase. The esd6/hos1 mutation causes decreased flowering ...
Tópico(s): Photosynthetic Processes and Mechanisms
2012 - Oxford University Press | The Plant Cell
A network of promoting and inhibiting pathways that respond to environmental and internal signals controls the flowering transition. The outcome of this regulatory network establishes, for any particular plant, the correct time of the year to flower. The photoperiod pathway channels inputs from light, day length, and the circadian clock to promote the floral transition. CONSTANS (CO) is a central regulator of this pathway, triggering the production of the mobile florigen hormone FT (FLOWERING LOCUS ...
Tópico(s): Photosynthetic Processes and Mechanisms
2011 - Oxford University Press | Journal of Experimental Botany
Day-length and the circadian clock control critical aspects of plant development such as the onset of reproduction by the photoperiodic pathway.1 CONSTANS (CO) regulates the expression of a florigenic mobile signal from leaves to the apical meristem and thus is central to the regulation of photoperiodic flowering.2 This regulatory control is present in all higher plants,3 but the time in evolution when it arose was unknown. We have shown that the genomes of green microalgae encode members of the ...
Tópico(s): Photosynthetic Processes and Mechanisms
2009 - Taylor & Francis | Plant Signaling & Behavior
Gloria Serrano, Rosana Herrera-Palau, J. Romero, Aurelio Serrano, George Coupland, Federico Valverde,
Summary Background The circadian clock controls several important processes in plant development, including the phase transition from vegetative growth to flowering. In Arabidopsis thaliana , the circadian-regulated gene CONSTANS ( CO ) plays a central role in the photoperiodic control of the floral transition, one of the most conserved flowering responses among distantly related plants. CO is a member of a plant-specific family of transcription factors, and when it arose during the evolution of higher plants ...
Tópico(s): Plant Molecular Biology Research
2009 - Elsevier BV | Current Biology
Tiziana Ventriglia, Misty L. Kuhn, María Teresa Gil Ruiz, Marina Ribeiro-Pedro, Federico Valverde, Miguel A. Ballícora, Jack Preiss, J. Romero,
ADP-glucose (Glc) pyrophosphorylase (ADP-Glc PPase) catalyzes the first committed step in starch biosynthesis. Higher plant ADP-Glc PPase is a heterotetramer (alpha(2)beta(2)) consisting of two small and two large subunits. There is increasing evidence that suggests that catalytic and regulatory properties of the enzyme from higher plants result from the synergy of both types of subunits. In Arabidopsis (Arabidopsis thaliana), two genes encode small subunits (APS1 and APS2) and four large subunits (APL1- ...
Tópico(s): Glycosylation and Glycoproteins Research
2008 - Oxford University Press | PLANT PHYSIOLOGY