Jonathan Northcroft, John Dugdale, William Kay, Barbara Hall, Roland white, Aa Gill, Esther Rantzen, Rbjt Allen, Scott Athorne, Camilla Morton, David Mills, Jon Swain, Tessa Mayes, Sally Brock, Helen Davies, Nicholas Rufford, Peter Whittle, Rob Hughes, Paul Moody's, Jason Dawe, John Peter, G C, Robert Greenhalgh, Bruce Millar, Graham Stonier, Andrew Longmore, John Waples Business Editor, Sandra Howard, Jenny Dyson, Frank Whitford, Paul Hornby, Matthew Davis, Terence Blacker, David Gower, Kathryn Cooper, P D, Lucy Hughes-Hallett, David Smith, Tim Richards, Archie Berens, Dan Snow, S Hayler, David Cracknell Political Editor, Nick Pitt, Stephanie Theobald, Frederic Raphael, Neil Wormald, E P, Andrew Sullivan, Clive Davis, Michael Durham's, Andrew Porter, Joseph Dunn, Tony Allen-Mills, Simon Wilde, Gemma Scott-Martin, Anthony Sattin, Robert Winnett, Irwin Stelzer, Adrian Furnham, Sean Fitzpatrick, Peter Wilson, Rosie Millard, David Dougill, Ben Neale, Matt Lovett, Rachel Zadok, Sarah-Kate Templeton Medical Correspondent, J C Higgins, Christopher Hart, Robert Winnett Whitehall Correspondent, Bobby Zamora, Stuart Barnes, Geraldine Hackett, G Anthony, Alan Combe, Rob Maul, Jonathon Carr-Brown, Paul Forsyth, Aston Martin, Geraldine Hackett Education Correspondent, Hugh Canning, Jeremy Clarkson, Victoria Segal, Edward Porter, Peter Conradi, David Cairns, Nicola Smith, Stewart Lee, Michael Portillo, Tom Betterton, Sarah Dempster, Greg Gordon, Kevin Jackson, Michael Jones, Richard Fletcher, Guy Sellers, James Delingpole, Lydia Slater, Demetrios Matheou, J W, Kathleen Kelly, John Young, L H, Sarah Meyer, Jeremy Guscott, David Vise, Andrew Thomas, Brian Moynahan, Brendan Bourne, David Walsh Chief Sports Writer, The Revd Dr Michael Ward, Peter Parker, Roger Eglin, Paul Donovan, Roy Bailey, Grae Hillary, Julian Fellowes, Alan Battison, Vincent Crump, Giles Hattersley, Steve Boyd, Billie Jean, Jasper Gerard, Paul Driver, John Follain, Walter Stevenson, Ian Hawkey, Samantha Hamilton, Stuart Andrews, Jasbinder Singh Flora, David Leppard, Tim Rayment, Paul Durman, Colin Harding, Shelley Von Strunckel, Roger Rolph, Lisa Grainger, Martyn Halle, Mark Edwards, Jenny Gage, Heston Blumenthal, Joel Hogg, Stephen Amidon, R d C, Martin Deeson, Stephen Jones rugby Correspondent, L W, Jo Evans, P W, Bharat Jashanmal, Boris Becker, Robert Holder, Raymond Keene, Jamie Foxx, Ken Carter, Rod Liddle, Douglas Alexander, Geoff Watson Founder of Hyperdrug Pharmaceuticals, David Cracknell, Derek Brewer, Dominic O'Connell Deputy Business Editor, Cosmo Landesman, Diana Wright, Kipper Williams, Alice Douglas, S B, Stephen Jones, Dominic O'Connell, Barry Flatman, Uzi Mahnaimi, Nick Cain, Louise Armitstead, Nicholas Boys Smith, Adrienne Connors, Anita Sethi, Caroline Donald, Lois Rogers Social Affairs Editor, Nick Rennison, Michael Jockson, Daniel Emary, David Walsh, Graham Norwood, Walter Payton, Helen Brown, Colin McDowell, Bryan Appleyard, Stephen Armstrong, John Elliott, Mark Stucklin, Christopher Goodwin, L C, D H, Richard Woods, Roland White, Steven Swinford, Mark Palmer, Shane Watson, Abul Taher, Dave Polland, Maurice Chittenden, Richard Brooks Arts Editor, Dean Bennett, John Elliott Consumer Affairs Correspondent, Virginia Rounding, Richard Rae, Ray Hutton, Jon Ungoed-Thomas, Gideon Gorter, Jonathan Leake, Brendan Simms, M E, Sophie Kirkham, David Crossland, Michael Sheridan, Andy Cole, Clare Francis, Lucy Ewing, B G V, Michael Smith, Frith Powell, Lesley Thomas, Chris Haslam, Stephen Hoare, Mark Kleinman, Tom Dunmore, John Waples, A A Gill, Alex Pell, Matthew Campbell, Brian Glanville, Kinvara Balfour, N W, Stephen Jones Rugby Correspondent, Simon Jenkins, Malcolm Goodson, Stephen Pettitt, Michael Horovitz, Will Iredale, Jonathan Leake Science Editor, Jessica Bown, John Spurling, T L, Simon West, Claudia Croft, Sally Kinnes, Peter Munro, Daniel Emery, John Aizlewood, Minette Marrin, Clifford Bishop, Adam Manktelow, Robert Service, James Scoltock, Andrew Frankel, John E Preston, Joe Lovejoy, Jonathan Futrell, Ali Hussain, John Crisfield, V Hibbs, Hugh Pearman, Sarah Raven, Andrew Davidson, Dan Cairns, Lucy Rouse, Mike Hammond, David Smith Economics Editor, Huw Beynon, J R, Susannah Price, Janie Omorogbe, Sarah Baxter, Brian Schofield, Malise Ruthven, Chris Feetenby, Kate Spicer, Matthew Goodman, India Knight, Sara Hassan, Joanna Simon, Simon Howard, Dr Alastair Scammell Consultant Paediatrician, Barry Newcombe, Dominic Rushe, Sian Griffiths, Karen Robinson, Helen Stewart,
... Desert by David Fisher Black Waltz by Patricia Melo Grace and Truth by Jennifer Johnston The Sunday ...
2005 - Gale Group | Sunday Times HA GDA
Evelyn Fessler, Jarno Drost, Sander R. van Hooff, Janneke F. Linnekamp, Xin Wang, Marnix Jansen, Felipe de Sousa e Melo, Pramudita R. Prasetyanti, Joep IJspeert, Marek Franitza, Peter Nürnberg, Carel J.M. van Noesel, Evelien Dekker, Louis Vermeulen, Hans Clevers, Jan Paul Medema,
... papers by this author Felipe De Sousa E Melo Felipe De Sousa E Melo Laboratory for Experimental Oncology ... papers by this author Felipe De Sousa E Melo Felipe De Sousa E Melo Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center ...
Tópico(s): Colorectal Cancer Treatments and Studies
2016 - Springer Nature | EMBO Molecular Medicine
Jonathan Northcroft, Waldemar Januszczak, John Dugdale, Matcon, Mary Gribbin, Barbara Hall, Nigel Botherway, Alec Stewart, Toby Young, Jon Swain, Rosie Waterhouse, Helen Davies, James Clark, Nicholas Rufford, Rob Hughes, John Peter, V S, Dan Pearson, Emma Moore, Amanda Ursell, Teresa Keane, Hamish Stevenson, Jonathan Miller, Mirwaz Khan, Felipe Fermández-Armesto, Gerd Sommerhoff, Luke Laszczak, Andrew Morgan, Jane Mulkerrins, Mike Broad, Kathy Brevis investigates, Nick Rufford, Ivo Tennant, Brian Dowling, Phil Cralgie, Packer, Kathryn Cooper, Sally Halon, Susan Bell, P D, Lucy Hughes-Hallett, David Smith, Kirstie Hamilton City Editor, Tim Richards, Edin Hamzic, Rory Godson, Humphrey Carpenter, David Cracknell Political Editor, Jibby Beane, E P, Andrew Sullivan, Clive Davis, Turna Ray, Carol Sarler, Guy Dennis, Gavin Ames, John Gaskell, Joseph Dunn, Tony Allen-Mills, Simon Wilde, Anthony Sattin, Robert Winnett, Irwin Stelzer, Peter Wilson, Rosie Millard, Brian Hardy, David Dougill, Rachel Dobson, A Blyth, Philip Kingsley, John Waples Deputy Business Editor, David Klass, Geraldine Hackett, Nigel Brotherway, Robert Peston, Nicholas Foulkes, John Swain, Tania Alexander, Alfred Taubman, Hugh Canning, Margarette Driscoll, Alasdair Reid, Alan Webster, Jeremy Clarkson, Victoria Segal, Edward Porter, Louise Taylor, Pd, Helen Kenny, Jane Renton, Eben Black, John O'Donnell, Greg Struthers, George Perry, Lydia Slater, Adam Nathan, Sir Richard Branson, Paul Bailey, Mike Laws, Stuart Wavell, Roger Eglin, Paul Donovan, Josephine Smit, Knife, Hugh McIlvanney, Lucinda Kemeny, Jasper Gerard, Paul Driver, Jim Sabourin, Michael Woodhead, John Humphrys, Garth Pearce, Boris Schapiro, Richard Brooks, Shelley Von Strunckel, Alex Clark, Nick Barley, David Leppard, Tim Rayment, Kandahar, Michael Hall, Paul Durman, Alicia Wyllie, Dorit Rabinyan, Mark Edwards, Kirstie Hamilton, Susan Clark, Stephen Amidon, David Lawrenson, Eben Black Chief Political Correspondent, Martin Ternouth, Bill Ganley, Danny O'Brien, Michael White, Jackie Clune's, Karen Gold, Victoria O'Brien, Raymond Keene, Hugh Cannng, Paul Bew, Douglas Alexander, Lindsay Duguid, David Cracknell, Cosmo Landesman, Robbie Hudson, Zoe Brennan, Marie Colvin, Colin Smith, Diana Wright, Nik Cohn, Angela Gokani Brasier, John Lee, Chris Partridge, Stephen Jones, Barry Flatman, Nick Cain, Richard Evans, Alex Wasef, Lara Logan, Nicholas Carter, Michael Wright, Horacio Silva, M J, Keith Wheatley, Mike Nicholls, Miranda Seymour, David Walsh, Jack Grimston, Colin McDowell, Bryan Appleyard, Stephen Armstrong, John Elliott, Christopher Davies, Christopher Goodwin, Tora Bora, R W Johnson, Roland White, Geoff Payne, John, Maurice Chittenden, Richard Brooks Arts Editor, Richard Rae, Mark Franchetti, Ray Hutton, Frank Fitzgibbon, Martin Ivens, S Roper, David Dixon, Kabul, Jonathan Diggines, Michael Sheridan, Amanda Craig, John Harlow, Godfrey Smith, Jeremy Buxton, Ps, Nicholas Gough, Dipesh Gadher, John Urbanek, Vinnie Jones, Brian East, John Waples, Barry Collins, Peter Willson, Nick Barker, James Herbert, Denis Walsh, Matthew Campbell, Brian Glanville, John Carey, A A Gill, Julian Coriett, Natalle Graham, Tom Robbins, David Sumner Smith, Ruth Myers, William Cash, Mazar-i-Sharif, Richard Towell, Hazel Curry, Sally Kinnes, Harriet Swain, Naomi Caine, Liam Clarke, Duncan Bryson, David Wickers, Alan Hayes, Nigel Powell, Fred Zinnemann, John Aizlewood, Jeremy Lazell, J Robertson, Mark Hodson, Andrew Frankel, Graham Norwood, Joe Lovejoy, Jonathan Futrell, Hugh Wood, Rupert Steiner, David Budworth, Andrew Davidson, Pete Oliver, Mrs Mills, Tom Deveson, Brain Christley, Simon Crerar, Peter Roebuck, Liz Ayre, Steve Grant, Simon Howard, Jeffrey Meyers, Barry Newcombe, Kathryn Johnston, Dominic Rushe, Richard Lewis, Sian Griffiths,
... By Lydia Slater And for the boys. . . Méli. Mélo Necklace, Delices de Cartier Collection Tutu much On ...
2001 - Gale Group | Sunday Times HA GDA
Produção Nacional
Revisado por pares
Miguel Martín, Elgene Lim, Mariana Chávez‐MacGregor, Aditya Bardia, Jiong Wu, Qingyuan Zhang, Zbigniew Nowecki, Felipe José Silva Melo Cruz, R. N. Safin, Sung‐Bae Kim, Christian Schem, Alberto J. Montero, Sarah Khan, Reeti Bandyopadhyay, Heather M. Moore, Mahesh Shivhare, Monika Patre, Jorge Martinalbo, Laura Roncoroni, Pablo Perez-Moreno, Joohyuk Sohn, G. Aguil, Marcos E. Alfie, Valeria Cáceres, Guillermo Lerzo, Sandra A. Ostoich, F. Boyle, Elgene Lim, Hayes Martin, Catherine Oakman, Felipe Melo Cruz, Fábio Franke, André Mattar, E.H. Silva, Katsuki Arima Tiscoski, Wei Chen, Wěi Li, Zhongsheng Tong, Jing Wang, Shaomeng Wang, X. Wang, Jiong Wu, Xiao‐Yuan Wu, Ju Yang, Q. Zhang, Till‐Oliver Emde, G. Gaffunder, Carsten Hielscher, Michael P. Lux, Christian Schem, Manfred Welslau, Claudia Schumacher, I. Kuchuk, T Peretz, Larisa Ryvo, R. Yerushalmi, Hee Dong Chae, Y.S. Chae, Seock‐Ah Im, Hwa Jung Kim, Jie‐Hyun Kim, S.-B. Kim, Jung Eun Lee, Y. H. Park, Joohyuk Sohn, Michał Jarząb, Monika Nowaczyk, Zbigniew Nowecki, Tadeusz Pieńkowski, Marek Z. Wojtukiewicz, Piotr J. Wysocki, E. Fomin, I. P. Ganshina, Nikolay Kislov, М. В. Копп, Н. В. Коваленко, Y. Makarova, Marina Matrosova, Р. В. Орлова, Artem Poltoratsky, Р. Р. Сафин, Р. А. Зуков, A. Wong, Yoon Sim Yap, M.A. Coccia-Portugal, Nicolaas H. Fourie, R. Khanyile, L. Schoeman, Ta‐Chung Chao, S.-T. Chen, Wei‐Pang Chung, Yin‐Hsun Feng, Yung‐Chang Lin, Thitiya Dejthevaporn, Napa Parinyanitikul, Chirawadee Sathitruangsak, Areewan Somwangprasert, Piyawan Tienchaianada, Ahmet Alacacıoğlu, Efnan Algın, Devrim Çabuk, Cengiz Demır, Umut Demırcı, Di̇lek Erdem, Sukru Hakan Gunduz, Murat Yıldırım, Siraj Ahmed Khan, Peter Schmid, I. Sandri, Olga Oikonomidou, Tameem Ansari, Apostolos Konstantis, S. Hrybach, A. Krochkin, O. Lipetska, D. Osinskii, S. Hrybach, A. Krochkin, O. Lipetska, D. Osinskii, J.C. Andersen, Michelina Cairo, Patrick Cobb, Venu Madhav Konala, Steve McCune, Alberto J. Montero, Debra A. Patt, Ines J Sanchez-Rivera, JJ Strain, KB Wendell,
PURPOSE To compare giredestrant and physician's choice of endocrine monotherapy (PCET) for estrogen receptor–positive, HER2-negative, advanced breast cancer (BC) in the phase II acelERA BC study (ClinicalTrials.gov identifier: NCT04576455 ). METHODS Post-/pre-/perimenopausal women, or men, age 18 years or older with measurable disease/evaluable bone lesions, whose disease progressed after 1-2 lines of systemic therapy (≤1 targeted, ≤1 chemotherapy regimen, prior fulvestrant allowed) were randomly assigned ...
Tópico(s): HER2/EGFR in Cancer Research
2024 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
E. Melo Felipe de Sousa, Louis Vermeulen, Dick J. Richel, Jan Paul Medema,
The identification of cancer stem cell (CSC) populations in virtually all tumor types has widespread clinical consequences. CSCs are suggested to be the only cells within malignancies endowed with tumorigenic capacity and are, therefore, directly implicated in therapy resistance and minimal residual disease. The genetic and molecular mechanisms sustaining CSCs are only currently emerging. For instance, aberrant activation of the Wnt signaling pathway is crucial for many cancer types and especially ...
Tópico(s): Cancer Cells and Metastasis
2010 - American Association for Cancer Research | Clinical Cancer Research
Luis Paz‐Ares, Óscar Juan, Giannis Mountzios, Enriqueta Felip, Niels Reinmuth, Filippo de Marinis, Nicolas Girard, Vipul M. Patel, Takayuki Takahama, Scott Owen, Douglas Reznick, Firas Badin, İrfan Çiçin, Sabeen Mekan, Riddhi Patel, Éric Zhang, Divyadeep Karumanchi, Marina Chiara Garassino, Elizabeth Ahern, Venessa Chin, Stephen Della‐Fiorentina, Kevin Jasas, Christos S. Karapetis, Jeremy Long, Louise Nott, Kenneth J. O’Byrne, Craig Underhill, Richard Greil, Maximilian J. Hochmair, Andreas Pircher, Wim Demey, Paul Germonpré, Elke Govaerts, Thierry Pieters, Reinier Wener, Alan A. Azambuja, Giuliano Santos Borges, Gilberto de Castro, Suellen Castro, Felipe Melo Cruz, Fábio Franke, Eduardo Silva, Parneet Cheema, Robert H. El-Maraghi, Swati Kulkarni, Rami Nassabein, Scott Owen, Clarisse Audigier-Valette, Jaafar Bennouna, C. Chouaïd, Alexis B. Cortot, S. Couraud, D. Debieuvre, Fabrice Denis, Patrick Dumont, Radj Gervais, Nicolas Girard, Etienne Giroux‐Leprieur, Florian Guisier, Sandrine Hiret, Henri Janicot, Corinne Lamour, J. Madelaine, M. Marcq, E. Pluquet, Jean Louis Pujol, Magali Ravoire, Marielle Sabatini, A. Vergnenègre, Sabine Bohnet, Martin Faehling, Melanie Janning, Eckart Laack, Niels Reinmuth, Achim Rittmeyer, Claas Wesseler, Sofia Baka, George Fountzilas, Panagiotis Katsaounis, Athanasios Κotsakis, Ioannis Mountzios, Konstantinos Syrigos, Julia Dudnik, Fink Carmel, Ofer Merimsky, Hovav Nechushtan, Julia Sobolev, Franceso Agustoni, Anna Bettini, Matteo Brighenti, Giulio Cerea, Filippo de Marinis, Salvatore Grisanti, Francesco Grossi, Andrea Luciani, Evaristo Maiello, Héctor Soto Parrà, Pierfrancesco Tassone, Giuseppe Tonini, Yoko Agemi, Koichi Azuma, Tomohisa Baba, Yuka Fujita, Eiki Ichihara, Takashi Kasai, Terufumi Kato, Haruki Kobayashi, Shoichi Kuyama, Kazumi Nishino, Masahide Oki, Kyoichi Okishio, Tomohiro Sakamoto, Yuki Sato, Yuki Shinno, Takayuki Takahama, Koichi Takayama, Yasutaka Watanabe, Noriko Yanagitani, Yoshitaka Zenke, Daniel Kuba, Tomas Daniel Pineda Razo, Robin Cornelissen, Lizza E.L. Hendriks, Jeroen S. Kloover, Klaar Maas, Cor van der Leest, Lubomir Bodnar, Bogusława Karaszewska, Andrzej Mruk, Paula Alves, António Araújo, Isabel Domingues, Ana da Conceicao Fernandes Rodrigues, Nuno Gil, Helena Magalhães, Bárbara Parente, Márcia Mara Corrêa, Hector A. Velez-Cortes, Andres Aguilar Hernandez, Ruben Alonso Calderon, Joaquim Bosch Barrera, David Vicente Baz, Antonio Calles, Maria Campelo, F.J. de Castro Carpeño, Enric Carcereny, Manuel Cobo, M. Dómine Gómez, Miguel F. Sanmamed, E. Felip Font, José Fuentes, Pilar Garrido, Óscar Juan, J.L. González-Larriba, Laia Martínez, Ramón Palmero, Silverio Ros, Jon Zugazagoitia Fraile, Ahmet Bılıcı, İrfan Çiçin, Umut Demırcı, Yeşim Eralp, Mahmut Gümüş, Ozan Yazıcı, Shobhit Baijal, K. Clarke, Farah Louise Lim, D. Muthukumar, N. Steele, Yvonne Summers, Ahmed Abdelaziz, Eric J. Avery, Firas Badin, Charles Connor, Davey B. Daniel, Amir Faridi, January Fields-Meehan, Marina Chiara Garassino, Todd Gersten, Daniel Haggstrom, David Hakimian, William Houck, Henrik Illum, Roger Keresztes, Charles Vincent Kurkul, Charles Kuzma, Rachel E. Lerner, Steven Liu, Smitha Menon, Rami Owera, Vipul Patel, Ivor Percent, Andrew J. Piper-Valillo, Sucharu Prakash, Douglas Reznick, Jorge Arturo Rios-Perez, Jun Sun, Restituto Tibayan, Anne M. Traynor, William D. Walsh, Donald B. Wender,
The open-label, phase III EVOKE-01 study evaluated sacituzumab govitecan (SG) versus standard-of-care docetaxel in metastatic non-small cell lung cancer (mNSCLC) with progression on/after platinum-based chemotherapy, anti-PD-(L)1, and targeted treatment for actionable genomic alterations (AGAs). Primary analysis is reported.
Tópico(s): Lung Cancer Research Studies
2024 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Ignace Vergote, Antonio González‐Martín, Keiichi Fujiwara, Elsa Kalbacher, Andrea Bagaméri, Sharad Ghamande, Jung‐Yun Lee, Susana Banerjee, Fernando Cotait Maluf, Domenica Lorusso, Kan Yonemori, Els Van Nieuwenhuysen, Luís Manso, Linn Woelber, Anneke M. Westermann, Allan Covens, Kosei Hasegawa, Byoung‐Gie Kim, Miriam Raimondo, Maria Bjurberg, Felipe Melo Cruz, Antoine Angelergues, David Cibula, Lisa Barraclough, Ana Oaknin, Christine Gennigens, L. Nicacio, Melinda Siew Leng Teng, Elizabeth Whalley, Ibrahima Soumaoro, Brian M. Slomovitz,
Recurrent cervical cancer is a life-threatening disease, with limited treatment options available when disease progression occurs after first-line combination therapy.
Tópico(s): Lung Cancer Treatments and Mutations
2024 - Massachusetts Medical Society | New England Journal of Medicine
Kim N., Dana E. Rathkopf, Matthew R. Smith, Eleni Efstathiou, Gerhardt Attard, David Olmos, Ji Youl Lee, Eric J. Small, Andrea Juliana Pereira de Santana Gomes, Guilhem Roubaud, Marniza Saad, Bogdan Żurawski, V.S. Sakalo, Gary Mason, Peter Francis, George Wang, Daphne Wu, Brooke Diorio, Angela Lopez‐Gitlitz, Shahneen Sandhu, María Alejandra Álvarez, Gabriela Gatica, Martín Greco, Ernesto Korbenfeld, Esteban Metrebián, Jorge Salinas, Alejandro Salvatierra, Marcelo Tatangelo, Tom Ferguson, Howard Gurney, Elizabeth Hovey, Anthony M. Joshua, Matos Marco, Gavin Marx, Michelle Morris, Siobhan Ng, David Pook, Shahneen Sandhu, Ali Tafreshi, Thean Hsiang Tan, Tsvetanka Tosheva, Livia Andrade, Felipe Melo Cruz, Luiza Dib Batista Bugiato Faria, J. M. L. Figueiredo, Fábio Franke, Andrea Juliana Pereira de Santana Gomes, Ariel Galapo Kann, Celio Kussumoto, Suelen Patrícia dos Santos Martins, André M. Murad, Hélio Pinczowski, Giovani Thomaz Pioner, Luís Ferreira Pires, Daniel D’Almeida Preto, Gisele Marinho dos Santos, Eduardo Silva, Jamile Silva, Luciano de Souza Viana, Karina Vianna, Adriano Augusto Peclat de Paula, Zhiwen Chen, Kim Chi, Urban Emmenegger, Neil Fleshner, Sunil Parimi, Fred Saad, Francisco Vera-Badillo, Hongqian Guo, Hong Luo, Ma Lulin, Mingxing Qui, Wei Xue, Yong-Lian Guo, Lei Li, Jinxian Pu, Song Zheng, Qing Zou, Miloš Broďák, Milan Hora, Vladimír Šámal, Vladimír Študent, J Vaňásek, Emmanuelle Bompas, Philippe Barthélémy, Delphine Borchiellini, Aude Fléchon, Hakim Mahammedi, Guilhem Roubaud, Antoine Thiery-Vuillemin, Diégo Tosi, Dominique Spaëth, Carole Hélissey, Martin Boegemann, Susan Feyerabend, Eva Hellmis, Martin Schostak, Gerhardt Attard, Anna Lydon, Ian Sayers, Omi Parikh, Duncan Wheatley, Peter Arkosy, József Erfán, Lajos Géczi, Péter Nyírády, Judit Oláh, István Papos, Béla Pikó, Raanan Berger, Avivit Peer, Umberto Basso, Sergio Bracarda, Orazio Caffo, Francesco Carrozza, Gianluca Del Conte, Luca Galli, Donatello Gasparro, Sandro Pignata, Riccardo Ricotta, Daniele Santini, Giampaolo Tortora, Seok‐Soo Byun, SeolHo Choo, Byung Ha Chung, Jaeyoung Joung, Wonho Jung, Taek Won Kang, Cheol Kwak, TaeGyun Kwon, Hyo Jin Lee, Ji Youl Lee, SeongIl Seo, Young Deuk Choi, H.K. Ha, ChoungSoo Kim, Flora Li Tze Chong, Chun Sen Lim, Vijayan Manogran, Hwoei Fen Soo Hoo, Guan Chou Teh, Marniza Saad, David Calvo Dominguez, Abraham Cardenas, J. Ángel García Sáenz, Andries M. Bergman, Helgi H. Helgason, Cornelis B. Hunting, R. Somford, Tomasz Byrski, Tomasz Drewa, Dorota Filarska, Jolanta LuniewskaBury, Adam Marcheluk, Konrad Tałasiewicz, Krzysztof Tupikowski, Renata Zaucha, Bogdan Żurawski, Pedro P. Madeira, André Mansinho, Nuno Vau, Anna Alyasova, Victoria Chistyakova, Denis Khvorostenko, Dmitry Kirtbaya, Г. П. Колесников, Evgeny Kopyltsov, Igor Lifirenko, А. П. Лыков, Konstantin Penkov, Andrey Semenov, М. I. Shkolnik, Pavel Skopin, R. V. Smirnov, Evgeny A. Usynin, Sergey Varlamov, Vladimir Vladimirov, Teresa Alonso, Sara Martínez Breijo, Elena Castro, Enrique Gallardo, Jose Gutierrez Banos, Álvaro Juárez, Rebeca Lozano, Pablo Maroto, Javier Puente, Alejo Rodríguez‐Vida, Regina Gironés, Begoña Mellado, E.A. Castellanos Abella, Chunde Li, Chao‐Hsiang Chang, Hsiao‐Jen Chung, Kuan‐Hua Huang, Yen‐Chuan Ou, Yu‐Chieh Tsai, Shian‐Shiang Wang, Wen‐Jeng Wu, See Tong Pang, Çağatay Arslan, Devrim Çabuk, Hasan Şenol Çoşkun, Mahmut Gümüş, Mustafa Özgüroğlu, Berna Öksüzoğlu, Berksoy Şahin, Deniz Tural, Bülent Yalçın, İrfan Çiçin, Igor Bondarenko, Yaroslav Gotsuliak, Yevhen Hotko, Геннадій Хареба, Oleksandr Lychkovskyy, Iryna Lytvyn, Taron Nalbandyan, V. M. Paramonov, V.S. Sakalo, E. O. Stakhovsky, V.P. Stus, Sunil Babu, Alan H. Bryce, David Cahn, Herta H. Chao, Franklin Chu, Curtis Dunshee, Oscar B. Goodman, Michael Grable, Jason Hafron, Joelle Hamilton, Ralph J. Hauke, Joseph Maly, David Morris, Gregg C. Newman, Patrick G. Pilié, Neal D. Shore, Paul Sieber, Matthew R. Smith, Andrew Trainer, Ronald Tutrone,
Metastatic castration-resistant prostate cancer (mCRPC) remains a lethal disease with current standard-of-care therapies. Homologous recombination repair (HRR) gene alterations, including
Tópico(s): Multiple Myeloma Research and Treatments
2023 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Produção Nacional
Revisado por pares
Gerald W. Prager, Julien Taı̈eb, Marwan Fakih, Fortunato Ciardiello, Eric Van Cutsem, Elena Élez, Felipe Melo Cruz, Lucjan Wyrwicz, Daniil Stroyakovskiy, Zsuzsanna Pápai, Pierre-Guillaume Poureau, Gábor Liposits, Chiara Cremolini, Igor Bondarenko, Dominik Paul Modest, Karim A. Benhadji, Nadia Amellal, Catherine Leger, Loïck Vidot, Josep Tabernero,
In a previous phase 3 trial, treatment with trifluridine-tipiracil (FTD-TPI) prolonged overall survival among patients with metastatic colorectal cancer. Preliminary data from single-group and randomized phase 2 trials suggest that treatment with FTD-TPI in addition to bevacizumab has the potential to extend survival.We randomly assigned, in a 1:1 ratio, adult patients who had received no more than two previous chemotherapy regimens for the treatment of advanced colorectal cancer to receive FTD-TPI ...
Tópico(s): Genetic factors in colorectal cancer
2023 - Massachusetts Medical Society | New England Journal of Medicine
Produção Nacional
Revisado por pares
Josep Tabernero, Gerald W. Prager, Marwan Fakih, Fortunato Ciardiello, Eric Van Cutsem, Elena Élez, Felipe Melo Cruz, Lucjan Wyrwicz, Daniil Stroyakovskiy, Zsuzsanna Pápai, Pierre-Guillaume Poureau, Gábor Liposits, Chiara Cremolini, Igor Bondarenko, Dominik Paul Modest, Karim A. Benhadji, Ronan Fougeray, Catherine Leger, Nadia Amellal, Julien Taı̈eb,
4 Background: Trifluridine/tipiracil (FTD/TPI) plus bevacizumab (Bev) demonstrated promising efficacy in a randomized phase 2 trial of heavily pretreated patients (pts) with metastatic colorectal cancer (mCRC). SUNLIGHT was conducted to confirm these findings. Methods: The global phase 3 SUNLIGHT study enrolled pts aged ≥18 years with histologically confirmed mCRC, ECOG PS 0/1, and treated with 1-2 prior chemotherapy regimens in an advanced setting, including fluoropyrimidines, irinotecan, oxaliplatin, ...
Tópico(s): Colorectal Cancer Surgical Treatments
2023 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Produção Nacional
Revisado por pares
Sun Young Rha, Do‐Youn Oh, Patricio Yañez, Yuxian Bai, Min‐Hee Ryu, Jeeyun Lee, Fernando Rivera, Gustavo Vasconcelos Alves, Marcelo Garrido, Kai‐Keen Shiu, M. Fernández, Jin Li, Maeve A. Lowery, Timuçin Çil, Felipe Melo Cruz, Shukui Qin, Suxia Luo, Hongming Pan, Zev A. Wainberg, Lina Yin, Sonal Bordia, Pooja Bhagia, Lucjan Wyrwicz, Guillermo Méndez, Juan Manuel O’Connor, Alvaro Yanzi Castilla, Juan Cundom, Diego Kaen, Rachel Wong, Weng Ng, Morteza Aghmesheh, Mauricio Peressoni, Carlos Eduardo Mattos da Cunha Andrade, Fábio Franke, Gustavo R. Alves, Felipe Jose Cruz, Karina Vianna, Maria Marcela Monteiro, Michael J. Raphael, Scott Berry, Raymond Woo-Jun Jang, Ann Tan, Jamil Asselah, Patricio Yanez Weber, Mauricio Mahave, César Sánchez, Pamela Salman, Yuxian Bai, Jin Li, Xiaochun Zhang, Tianshu Liu, Xiaoyan Lin, Shukui Qin, Jianwei Yang, Suxia Luo, Wěi Li, Jieer Ying, Xi Chen, Shan Zeng, Yanli Qu, Lin Yang, Lin Zhao, Ping Chen, Hongming Pan, Enxiao Li, Feng Ye, Jianwei Lu, Xinjun Liang, Qun Zhao, Xianli Yin, Junhe Li, Ling Yang, Guoqing Lv, Shouguo Li, Álvaro Guerrero, Juan Rubiano, M. Fernández, Ray Manneh Kopp, Adrian Guzman Ramirez, Luis Corrales, Ileana Gonzalez Herrera, Bohuslav Melichar, Tomáš Büchler, Tomáš Svoboda, Radka Obermannová, David Vrána, Jakub Cvek, Per Pfeiffer, Lene Bæksgaard, Mette Yilmaz, Valérie Boige, Daniel López‐Trabada, Christophe Borg, Diane Pannier, Sandrine Hiret, Frédéric Di Fiore, Jean‐Philippe Metges, Dirk Arnold, Uwe M. Martens, Florian Lordick, Alexander Stein, Hugo R. Castro, Karla Alejandra Lopez, Julio A. Ramírez, Mynor Aguilar, Marco Chivalan, Wing‐Lok Chan, Ashley Cheng, Winnie Yeo, Peter Arkosy, Tibor Csöszi, Erika Hitre, Zsolt Horváth, Maeve A. Lowery, Ray McDermott, Patrick G. Morris, Ayala Hubert, Baruch Brenner, Irit Ben‐Aharon, Einat Shacham‐Shmueli, Sofia Man, Sharon Pelles Avraham, Ronen Brenner, Moshe Mishaeli, Maria Di Bartolomeo, Nicola Fazio, Sara Lonardi, Carlo Garufi, Taroh Satoh, Hiroki Hara, Shiro Iwagami, Hisateru Yasui, Masahiro Tsuda, Tatsu Shimoyama, Hirokazu Shoji, Naotoshi Sugimoto, Nobuhiro Shibata, Kensei Yamaguchi, Kenji Amagai, Yasuhiro Choda, Taito Esaki, Hiroshi Yabusaki, Takashi Oshima, Akihito Tsuji, Hisato Kawakami, Akihito Kawazoe, Kenji Ishido, Shigenori Kadowaki, Jorge Martinez Rodriguez, Marytere Herrera Martínez, Fidel Huitzil Melendez, Francisco Ramirez Godinez, Paola Balancan, Dragan Damianovich, Victor Castro Oliden, Julio Grados, César Torres, Lucjan Wyrwicz, Piotr J. Wysocki, Łukasz Hajac, Jakub Żołnierek, Boguslawa Karaszewska, Sun Young Rha, Jeeyun Lee, Min‐Hee Ryu, Do‐Youn Oh, Р. В. Орлова, S. Tjulandin, Natalia Fadeeva, Yulia Makarycheva, Dmitry Nosov, Maria Smagina, Sze Ham Chan, Conrad Jacobs, P Kraus, Gregory Landers, Barbara Robertson, Paul Ruff, Elizabeth Schoeman, Jean-Marc Maurel, M. Díez García, Paula Jiménez Fonseca, Javier Gállego, F. Rivera Herrero, Jesús Miranda, L. Layos Romero, Ralph Fritsch, Sara Bastian, Sun Young Rha, Sara De Dosso, Thibaud Kössler, Kun‐Huei Yeh, Chia‐Jui Yen, Yen‐Yang Chen, Johnson Lin, Mehmet Bilici, Mustafa Özgüroğlu, Timuçin Çil, Berna Öksüzoğlu, Hakan Harputluoğlu, Aziz Karaoğlu, İlhan Hacıbekiroğlu, Bülent Erdoğan, Şuayib Yalçın, Hryhoriy Adamchuk, Igor Bondarenko, Oleksii Kolesnik, Yuriy Ostapenko, Anna Kryzhanivska, Lurii Leshchenko, Ievgen Ilin, Yaroslav Shparyk, Dmytro Trukhin, Олександр Войтко, Rajarshi Roy, Anna-Mary Young, Louise Medley, Kai‐Keen Shiu, Paul Celano, Lindsay Overton, Moses S. Raj, Richard F. Dunne, Zev A. Wainberg, Farshid Dayyani, Timothy Larson, Mark D. Kochenderfer,
Summary Background PD-1 inhibitors combined with chemotherapy have shown efficacy in gastric or gastro-esophageal junction cancer. We compared the efficacy and safety of pembrolizumab plus chemotherapy with placebo plus chemotherapy in participants with locally advanced or metastatic HER2-negative gastric or gastro-esophageal junction adenocarcinoma. Methods KEYNOTE-859 is a multicentre, double-blind, placebo-controlled, randomised, phase 3 trial, done at 207 medical centres across 33 countries. Eligible ...
Tópico(s): Pancreatic and Hepatic Oncology Research
2023 - Elsevier BV | The Lancet Oncology
Produção Nacional
Revisado por pares
Elizabeth Shephard, Marcelo C. Batistuzzo, Marcelo Q. Hoexter, Emily Stern, Pedro Fonseca Zuccolo, Carolina Yuri Ogawa, Renata de Melo Felipe da Silva, André R. Brunoni, Daniel L. Costa, Victoria Fogaça Doretto, Leonardo Saraiva, Carolina Cappi, Roseli Gedanke Shavitt, H. Blair Simpson, Odile A. van den Heuvel, Eurípedes C. Miguel,
Obsessive-compulsive disorder (OCD) is a common psychiatric condition classically characterized by obsessions (recurrent, intrusive and unwanted thoughts) and compulsions (excessive, repetitive and ritualistic behaviors or mental acts). OCD is heterogeneous in its clinical presentation and not all patients respond to first-line treatments. Several neurocircuit models of OCD have been proposed with the aim of providing a better understanding of the neural and cognitive mechanisms involved in the disorder. ...
Tópico(s): Autism Spectrum Disorder Research
2021 - Associação Brasileira de Psiquiatria | Brazilian Journal of Psychiatry
Produção Nacional
Revisado por pares
Renata de Melo Felipe da Silva, André R. Brunoni, Stephan Goerigk, Marcelo C. Batistuzzo, Daniel L. Costa, Juliana Belo Diniz, Frank Padberg, Giordano D’Urso, Eurípedes C. Miguel, Roseli Gedanke Shavitt,
Obsessive-compulsive disorder (OCD) is a frequent, disabling disorder with high rates of treatment resistance. Transcranial direct current stimulation (tDCS) is a safe, tolerable noninvasive neuromodulation therapy with scarce evidence for OCD. This double-blind, randomized, and sham-controlled study investigates the efficacy of tDCS as add-on treatment for treatment-resistant OCD (failure to respond to at least one previous pharmacological treatment). On 20 consecutive weekdays (4 weeks), 43 patients ...
Tópico(s): Neural and Behavioral Psychology Studies
2021 - Springer Nature | Neuropsychopharmacology
Produção Nacional
Revisado por pares
Renata de Melo Felipe da Silva, Roseli Gedanke Shavitt, Daniel L. Costa,
Tópico(s): Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
2020 - Associação Brasileira de Psiquiatria | Brazilian Journal of Psychiatry
Produção Nacional
Revisado por pares
Renata de Melo Felipe da Silva, Marcelo C. Batistuzzo, Roseli Gedanke Shavitt, Eurípedes C. Miguel, Emily Stern, Eva Mezger, Frank Padberg, Giordano D’Urso, André R. Brunoni,
Introduction: Transcranial Direct Current Stimulation (tDCS) is a non-invasive brain stimulation intervention that has been investigated for several psychiatric disorders, including Obsessive-Compulsive Disorder (OCD). As there are several candidate brain regions for targeting OCD relevant networks, clinical studies using tDCS have considerably varied in terms of the electrode montages used. Computer modeling of electric field currents induced by tDCS can help guiding the research of relevant targets ...
Tópico(s): Neural and Behavioral Psychology Studies
2019 - Taylor & Francis | Expert Review of Neurotherapeutics
Produção Nacional
Revisado por pares
Ygor Arzeno Ferrão, Renata de Melo Felipe da Silva,
Despite the role of anxiety in these previous studies, in our analysis, we found that agitation, less retardation, less depressed mood, less somatic symptoms, and more weight loss seem to characterize the caregivers of symptomatic versus asymptomatic children.When comparing only caregivers of symptomatic children, those caring for children with impact presented higher levels of anxiety, which is in line with the existing literature.Greater knowledge of mechanisms underlying caregiver-offspring interactions ...
Tópico(s): Migraine and Headache Studies
2018 - Associação Brasileira de Psiquiatria | Brazilian Journal of Psychiatry
Produção Nacional
Revisado por pares
Renata de Melo Felipe, Ygor Arzeno Ferrão,
Abstract Introduction: Pregnancy is characterized by a high prevalence of mental disorders. Depression is the most common of these disorders and it is a risk factor for negative maternal and child development outcomes. Psychotherapy and pharmacotherapy are conventional and well-established therapeutic options, but some clients fail to respond and the safety of using some pharmacological agents during pregnancy is unclear. Some neuromodulation techniques, such as repetitive transcranial magnetic ...
Tópico(s): Migraine and Headache Studies
2016 - Associação de Psiquiatria do Rio Grande do Sul | Trends in Psychiatry and Psychotherapy
Produção Nacional
Revisado por pares
Renata de Melo Felipe da Silva, André R. Brunoni, Eurípedes C. Miguel, Roseli Gedanke Shavitt,
ABSTRACT CONTEXT AND OBJECTIVE: Neuromodulation techniques for treating obsessive-compulsive disorder (OCD) have expanded through greater understanding of the brain circuits involved in this disorder. Transcranial direct current stimulation (tDCS), a non-invasive technique, has been studied as an alternative for treatment-resistant OCD. We describe the design of a clinical trial using tDCS for OCD and report on the outcomes from two patients with primary OCD who were resistant to cognitive-behavioral ...
Tópico(s): Body Image and Dysmorphia Studies
2016 - Medical Association of São Paulo | Sao Paulo Medical Journal
G. Frank Mathewson, Ralph A. Winter,
... doi.org/10.1177/0019793915586384PEDRO LUCAS DE RESENDE MELO, FELIPE MENDES BORINI, MOACIR DE MIRANDA OLIVEIRA JR, RONALDO ...
Tópico(s): Auction Theory and Applications
1985 - University of Chicago Press | The Journal of Law and Economics
Produção Nacional
Revisado por pares
Brener Felipe Melo Lima Gomes, Caroline Maria Bezerra de Araújo, Bruna Figueiredo do Nascimento, Ronald Keverson da Silva Santos, Eleonora Maria Pereira de Luna Freire, Maurı́cio Alves da Motta Sobrinho, Marilda Nascimento Carvalho,
In this work, an agar-graphene oxide hydrogel was prepared to adsorb Cd (II) and Methyl Violet (MV) from water. The hydrogel was synthesised and characterised through SEM and EDS. Kinetic, equilibrium and regeneration studies were carried out, in which Langmuir, Freundlich and Sips isotherm models were fitted to the equilibrium experimental data; and regarding the kinetics, studies were conducted by modelling experimental data considering both empirical and phenomenological models. SEM and EDS have ...
Tópico(s): Graphene and Nanomaterials Applications
2023 - Taylor & Francis | Environmental Technology
Produção Nacional
Revisado por pares
Mychael V. Lourenco, Felipe C. Ribeiro, Luís E. Santos, Danielle Beckman, Helen M. Melo, Felipe Kenji Sudo, Cláudia Drummond, Naima Assunção, Bart Vanderborght, Fernanda Tovar‐Moll, Fernanda G. De Felice, Paulo Mattos, Sérgio T. Ferreira,
Alzheimer's disease (AD) and Lewy body disease (LBD) are complex neurodegenerative disorders that have been associated with brain inflammation and impaired neurotransmission.We aimed to determine concentrations of multiple cytokines, chemokines, and neurotransmitters previously associated with brain inflammation and synapse function in cerebrospinal fluid (CSF) from AD and LBD patients.We examined a panel of 50 analytes comprising neurotransmitters, cytokines, chemokines, and hormones in CSF in a cohort ...
Tópico(s): Neurological Disorders and Treatments
2021 - IOS Press | Journal of Alzheimer s Disease
Constanza Méndez, Hernán F. Peñaloza, Bárbara M. Schultz, Alejandro Piña-Iturbe, Mariana Ríos, Daniela Moreno-Tapia, Patricia Pereira-Sánchez, Diane Leighton, Claudia Orellana, Consuelo Covarrubias, Nicolás M. S. Gálvez, Jorge A. Soto, Luisa F. Duarte, Daniela Rivera-Pérez, Yaneisi Vázquez, Alex Cabrera, Sergio Bustos, Carolina Iturriaga, Marcela Urzúa, María S Navarrete, Álvaro Rojas, Rodrigo Fasce, Jorge Onrubia Fernández, Judith Mora, Eugenio Ramı́rez, Aracelly Gaete-Argel, Mónica L. Acevedo, Fernando Valiente‐Echeverría, Ricardo Soto‐Rifo, Daniela Weiskopf, Alba Grifoni, Alessandro Sette, Gang Zeng, Weining Meng, José Vicente González-Aramúndiz, Pablo A. González, Katia Abarca, Felipe Melo-González, Susan M. Bueno, Alexis M. Kalergis, Álvaro Rojas, María S Navarrete, Constanza del Río, Dinely Del Pino, Natalia Aguirre, Grecia Salinas, Franco Vega, Acsa Salgado, Thomas Quinteros, Marlene Ortiz, Marcela Puente, Alma Muñoz, Patricio Astudillo, Nicole Le Corre, Marcela Potı́n, J.P. Catalán, Melan Peralta, Consuelo Zamanillo, Nicole Keller, Rocío Fernández, Sofía Aljaro, Sofía López, José Tomás González, Tania Weil, Luz Opazo, P. Rubio Muñoz, Inés Estay, Miguel Cantillana, Liliana Carrera, Matías Masalleras, Paula Guzmán, Francisca Aguirre, Aarón Cortés, Luis Federico Bátiz, Javiera Pérez, Karen Apablaza, L. D. Yates, María de los Ángeles Valdés, Bernardita Hurtado, Veronique Venteneul, Constanza Astorga, Paula Muñoz Venturelli, Pablo Vial, Andrea Schilling, Daniela Pavez, Inia Pérez, Amy Riviotta, Francisca González, Francisca Urrutia, Alejandra Del Río, Claudia Asenjo, Bárbara Vargas, Francisca Dias de Castro, Alejandra Acuña, Javiera Guzmán, Camila Astudillo, Carlos M. Pérez, Pilar Espinoza, Andrea Martínez, Marcela Arancibia, Harold V. Romero, Cecilia Bustamante, María Loreto Pérez, Natalia Uribe, Viviana Silva, Bernardita Morice, Marco Pérez, Marcela González, Werner Jensen, Claudia Pasten, M. Fernanda Aguilera, Nataly Martínez, Camila V. Molina, Sebastián Arrieta, Begoña López, Claudia Ortíz, Macarena Escobar, Camila Bustamante, Marcia Espinoza, Ángela Cuesta Pardo, Alison Carrasco, Miguel Montes, Macarena Saldías, Natalia Gutiérrez, Juliette Sánchez, Daniela Fuentes, Yolanda Calvo, Mariela Cepeda, Rosario Lemus, Muriel Suárez, Mercedes Armijo, Shirley Monsalves, Constance Marucich, Cecilia Cornejo, Ángela Acosta, Xaviera Prado, Francisca Yáñez, Marisol Barroeta, Clàudia López, Paulina Donato, Martín Lasso, María Iturrieta, Juan Pablo Giraldo, Francisco Gutiérrez, María Acuña, Ada Cascone, Raymundo Rojas, Camila Sepúlveda, Mario Contreras, Yessica Campisto, Pablo A. González, Zoila Quizhpi, Mariella López, Vania Pizzeghello, Stephannie Silva,
BackgroundThe Omicron variant has challenged the control of the COVID-19 pandemic due to its immuno-evasive properties. The administration of a booster dose of a SARS-CoV-2 vaccine showed positive effects in the immunogenicity against SARS-CoV-2, effect that is even enhanced after the administration of a second booster.MethodsDuring a phase-3 clinical trial, we evaluated the effect of a second booster of CoronaVac®, an inactivated vaccine administered 6 months after the first booster, in the neutralization ...
Tópico(s): Vaccine Coverage and Hesitancy
2023 - Elsevier BV | EBioMedicine
Produção Nacional
Revisado por pares
Sun Young Rha, Lucjan Wyrwicz, P.E. Yanez Weber, Yuxian Bai, Min‐Hee Ryu, Jeeyun Lee, Fernando Rivera, Gustavo Vasconcelos Alves, Marcelo Garrido, Kai‐Keen Shiu, M. Fernández, Jin Li, Maeve A. Lowery, Timuçin Çil, Felipe Melo Cruz, Shukui Qin, Lina Yin, Sonal Bordia, Pooja Bhagia, Do‐Youn Oh,
4014 Background: In the ITT population of the KEYNOTE-859 study of HER2-negative, advanced G/GEJ cancer (NCT03675737), pembrolizumab (pembro) + chemotherapy (chemo) significantly improved OS (HR 0.78, 95% CI 0.70-0.87; P < 0.0001), PFS (HR 0.76, 95% CI 0.67-0.85; P < 0.0001), and ORR (51.3% vs 42.0%; P = 0.00009) vs placebo + chemo at the protocol-specified interim analysis. The safety profile of pembro + chemo was as expected. We present efficacy outcomes of the protocol-specified PD-L1 combined positive score (CPS) ≥ ...
Tópico(s): Colorectal Cancer Treatments and Studies
2023 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Produção Nacional
Revisado por pares
Denise C. Arruda, Luana Cheven Perbore dos Santos, Filipe Menegatti de Melo, Felipe V. Pereira, Carlos R. Figueiredo, Alisson L. Matsuo, Renato A. Mortara, María A. Juliano, Elaine G. Rodrigues, Andrey S. Dobroff, Luciano Polonelli, Luiz R. Travassos,
Complementarity-determining regions (CDRs) from monoclonal antibodies tested as synthetic peptides display anti-infective and antitumor activities, independent of the specificity of the native antibody. Previously, we have shown that the synthetic peptide C7H2, based on the heavy chain CDR 2 from monoclonal antibody C7, a mAb directed to a mannoprotein of Candida albicans, significantly reduced B16F10 melanoma growth and lung colony formation by triggering tumor apoptosis. The mechanism, however, ...
Tópico(s): Monoclonal and Polyclonal Antibodies Research
2012 - Elsevier BV | Journal of Biological Chemistry
Produção Nacional
Revisado por pares
Adriana Bastos Conforto, Sarah dos Anjos, Gustavo Saposnik, Eduardo A. Mello, Erina M. Nagaya, W. S. dos Santos, Karina N. Ferreiro, Eduardo Sousa de Melo, Felipe Ibiapina dos Reis, Milberto Scaff, Leonardo G. Cohen,
Low-frequency repetitive transcranial magnetic stimulation (rTMS) of the unaffected hemisphere can enhance function of the paretic hand in patients with mild motor impairment. Effects of low-frequency rTMS to the contralesional motor cortex at an early stage of mild to severe hemiparesis after stroke are unknown. In this pilot, randomized, double-blind clinical trial we compared the effects of low-frequency rTMS or sham rTMS as add-on therapies to outpatient customary rehabilitation, in 30 patients ...
Tópico(s): Muscle activation and electromyography studies
2011 - Springer Science+Business Media | Journal of Neurology
Produção Nacional
Revisado por pares
Lucas Gabriel Maltoni Romano, Giuliano Bedoschi, Anderson Sanches de Melo, Felipe Oliveira de Albuquerque, Ana Carolina Japur de Sá Rosa e Silva, Rui Alberto Ferriani, Paula Andrea Navarro,
OBJETIVO: Comparar as características metabólicas de mulheres jovens do sudeste brasileiro, obesas e não obesas com síndrome dos ovários policísticos (SOP). MÉTODOS: Estudo transversal que incluiu 218 mulheres de idade reprodutiva com diagnóstico de SOP - 90 mulheres não obesas (IMC entre 18,5 e 29,9 kg/m²) e 128 pacientes obesas (IMC >30 kg/m²), selecionadas no momento do diagnóstico. Foram comparadas as frequências de resistência insulínica (RI), intolerância à glicose (IG), síndrome metabólica (MetS) ...
Tópico(s): Reproductive Biology and Fertility
2011 - Thieme Medical Publishers (Germany) | Revista Brasileira Ginecologia e Obstetrícia
Produção Nacional
Revisado por pares
Antonio Jorge Gonçalves Soares, Leonardo Bernardes Silva de Melo, Felipe Rodrígues da Costa, Tiago Lisboa Bartholo, Jorge Olímpio Bento,
O objetivo do estudo é refletir sobre a relação entre a profissionalização no futebol e a escolarização. O Brasil exportou para o exterior nos últimos seis anos 6.648 jogadores. Deste contingente emigraram para Europa 3.593, isto é, 54,0% do total. Argumentamos que estamos diante de uma agência que: recruta jovens do sexo masculino, em geral das camadas populares, para atuarem no mercado interno ou externo do futebol; e se configura num tipo de negócio que dá base à criação de uma indústria de formação ...
Tópico(s): Sport and Mega-Event Impacts
2011 - Colégio Brasileiro de Ciências do Esporte | Revista Brasileira de Ciências do Esporte
Produção Nacional
Revisado por pares
Aline Andrea da Cunha, Fernanda Bordignon Nunes, Adroaldo Lunardelli, Vânia Pauli, Robson Henrich Amaral, Luciana Mello de Oliveira, Vasyl Custódio Saciura, Gabriela Lucas da Silva, Melissa Guerra Simões Pires, Márcio Vinı́cius Fagundes Donadio, Denizar Alberto da Silva Melo, Felipe Dal‐Pizzol, José Cláudio Fonseca Moreira, Guilherme Antônio Behr, Carlos Luiz Reichel, José Luís Rosa, Jarbas Rodrigues de Oliveira,
Tópico(s): Neuropeptides and Animal Physiology
2011 - Elsevier BV | International Immunopharmacology
Produção Nacional
Revisado por pares
Vinicius S. De Stefano, Luiz Alberto S. Melo, Felipe Mallmann, Paulo Schor,
PURPOSE: Many systems try to replace Placido disc-based topographers, such as those based in Scheimpflug principles. The purpose of this study is to check if they are interchangeable. METHODS: Quantitative analysis evaluated data obtained from EyeSys and Pentacam, i.e. simulated keratometric values, in addition to flattest and steepest keratometric values. Sixty-three maps from each device (EyeSys scale=0.5 D; Pentacam scale= 0.25 D) were used for the comparison. Qualitative analysis selected 10 ...
Tópico(s): Ophthalmology and Visual Impairment Studies
2010 - Conselho Brasileiro de Oftalmologia | Arquivos Brasileiros de Oftalmologia
Produção Nacional
Revisado por pares
Mark Drew Crosland Guimarães, Gustavo Machado Rocha, Lorenza Nogueira Campos, Felipe Melo Teixeira de Freitas, Felipe Augusto Souza Gualberto, Ramiro d’Ávila Rivelli Teixeira, Fábio Morato de Castilho,
To describe the degree of difficulty that HIV-infected patients have with therapy treatment. Patients' perceptions about their treatment are a determinant factor for improved adherence and a better quality of life. Two cross-sectional analyses were conducted in public AIDS referral centers in Brazil among patients initiating treatment. Patients interviewed at baseline, after one month, and after seven months following the beginning of treatment were asked to classify and justify the degree of difficulty ...
Tópico(s): HIV Research and Treatment
2008 - Elsevier BV | Clinics