Dr. Eilhard Wiedemann, Otto Pfenninger, Dr. Adrien Guébhard, Dr. J. Würschmidt, K. Martin, Otto Pfenninger, Hans Schmidt, A. Seyewetz, A. Seyewetz, W. Zschokke, E. J. Wall, A. P. H. Trivelli, Fr. Paul Liesegang, Dr. Erich Stenger, M. Von Rohr, J. M. Eder, Privatdozent Fritz Weigert, A. Byk, H. Borck, Johannes Gaedicke, Dr. Chr. Jensen, A. Saal, K. W. Wolf-Czapek, Professor August Albert, E. Valenta, Dr. Jaroslav Husnik, Dr. G. Eberhard, Dr. Karl Kieser, Prof. Dr. Max Trautz, A. Cobenzl, N. S. Amstutz, Professor Rud. Namias, Professor Rud. Namias, Professor Rud. Namias, Dr. E. Goldberg, K. H. Broum, J. Waterhouse, H. Hinterberger, C. E. Kenneth Mees, Dr. Karl Schaum, Dr. Georg Hauberriszer, Dr. Gotthelf Leimbach, Chr. Winther, Wilhelm Urban, Professor Arthur W. Unger, Prof. Dr. Franz Novak, Professor J. Hartmann, Albin Von Palocsay, Dr. Leopold Freund, Eduard Kuchinka, Prof. Dr. Jaraslav Milbauer, Prof. Dr. W. Scheffer, Dr. A. Miethe, Prof. Dr. Emil Baur, Gottlieb Marktanner-Turneretscher,
... Verschluss-Auslöser, Farben-Photographie, Leonar=Werke, Aug. Koebig, Felix ... Bromwasser Als Photographisches Reagens, Diachromie, Einfluß Des Lichtes ...
1911 - Gale Group | NCCO Photography
Christina Dongowski, Georg Wagner-Kyora, Thomas Meyer, Dirk Thomaschke, Elke Wiechmann, Benjamin Bühler, Gesine Krüger, Christof Dipper, Jörg Echternkamp, Ralf Ahrens, Matthias Middell, Josef Ehmer, E.J. Weber Wolfgang, Markus End, Karola Fings, Christoph Nonn, Sina Fabian, Karsten Uhl, Detlev Brunner, Anne Gnausch, W. Daum, Manfred Berg, Godwin Kornes, Daniel Uziel, Monika Mattes, Aram Mattioli, Volker Köhler, Moritz Föllmer, Daniel Mollenhauer, Gudrun-Christine Schimpf, Hannah Ahlheim, Klaus-Peter Friedrich, Anja Pinkowsky, Matthias Falter, Anthony D. Kauders, Barbara Stambolis, Wolfgang Schieder, Kaspar Maase, Byron Schirbock, Jochen Boehler, Christian Geulen, Stephan H. Lindner, Nils Zurawski, Aline Maldener, Anke Fiedler, Yvonne Wasserloos, Jörg Roesler, Jost Dülffer, Yvonne Robel, Felicitas Söhner, Sabine Kittel, Christian Nestler, Franziska Martinsen, Annette Förster, Martin Hartmann, Felix Gerlsbeck, Ulrich von Alemann, Jan Rohgalf, Emanuel Richter, S. Wolf, P. A. de Graeff, Brigitte Kerchner,
Tópico(s): German Literature and Culture Studies
2016 - Springer VS | Neue Politische Literatur
Taki, Waldemar Januszczak, John Dugdale, Michael Prescott, Jennifer Roberts, John Coleman, Peggy Follis, Jim Munro, Helen Davidson, Andrew Samuels, Dan Pearson, John Peter, Jonathan Miller, Nick Rufford, Jason Burke, Dr Charles Socarides, Sheridan Morley, Ivo Tennant, Graham Rose, Christa D'souza, Sally Payne, Lucy Hughes-Hallett, David Smith, Nick Pitt, Frederic Raphael, Charles Hymas, Sebastian Hamilton, Clive Davis, Mary Wilson, David Mears, Arnold Evans, Brian Souter, Alimed Rashid, Alan Duncan, Michael Crick, David Leppard Home Affairs Correspondent, Geordie Greig, Tony Allen-Mills, Martin James, Robert Sandall, Mick Jagger, Stewart Trotter, Brian Maguire, Kirit Pathan, Alan Rudge deputy managing director of Bt, Kenneth Thompson, Robert Hewison, Roger Anderson, Mick Brown, David Dougill, Pat Gibson, Caroline Millar, John Evans, Stuart Wilson, Margaret Barrour, Philip Kerr, Peter Conradi Brussels, David Hewson, Andrew Dickson, Harvey Porlock, Hugh Canning, Hugh Mcllvanney, Jon Savage, Jeremy Clarkson, Martin George, Sean Ryan, Ann Gloag, Paco Pena, Simon Hinde, Caroline Lees, Kirstie Hamilton Deputy City Editor, Ron Swade, H Khaleeli, Joe, Peter Kellner, George Perry, Iris Stahi, Robin Marlar, Nick Gardner, Marie Louise Harvey, Shelley von Strunckel, Ardyn Bernoth, Jonathan Margolis, Paul Ham, Stuart Wavell, Hugh Channing, Paul Donovan, Malcolm Healey, Frances Spalding, Sue Lawrence, Jeff Randall, James Bethell, James Adams, George Schoflin, Ian Hawkey, Ian Chadband, David Leppard, Mary Lynne Ellis, Peter Beardsley, Richard Girling, Matt Seaton, Jack Dromey, Kirstie Hamilton, Tom Shone, David Lawrenson, Celia Moxom, Robert Buxton, Dave Thomas, Jon Culley, Bernard Matthews, Christopher Lloyd, Steve Coulter, Sean Newsom, Nick Curwin, Louise Evans Peking, John Karter, Stanley Stewart, Anna Lowe, Chris Lighthown, David Abrahams, Rufus Oilns, Harriet Jerram, Stephen Thorpe, Andrew Grice Chief Political Correspondent, Liz Lightfoot Legal Affairs Correspondent, Patricia Clough Munich, Patrick Gifford, Andrew Neil, Paul Nuki, Andrew Grice, Irwin Steizer, Peter Standford, Julie Cohen, Cathy Scott-Clark Education Reporter, Martin Searby, Keith Wheatley, Karl Ammann, Claire Oldfield, Christopher Lloyd Technology Editor, Michael Gottlieb, Rob Ryan, Anthony Quinn, Jan Pawel Jedrzejewski, Jenny McLEAN, Keith Martin, Jim Brunton, Nigel Mansell, Ian Burrell, Lois Rogers Medical Correspondent, Paul Nuki Personal Finance Editor, David Shapiro, Britt Allcroft, Christopher Goodwin, Alison Beckett, Richard Woods, Roland White, Garth Alexander, Antony Worrall Thompson, Peter Johnson, Sir Anthony Bamford, Maurice Chittenden, Eddie, Sir Terence Conran, Ray Hutton, Julie Burchill, Ardya Bernoth, Rebecca Fowler, Sir Donald Gosling, Jonathan Leake, David Hunn, John Harlow, Philip Beresford, Matthew Lynn, Godfrey Smith, Lesley Thomas, Michael Austin, Simon Chapman, Wolfgang Stutz, Andrew Alderson, John Waples, Craig Thomas, Jonathan Ross, Andrew Malone, Norman Macrae, Winner's Dinners, Lauren St John, Tony O'Brien, Anna Pukas, Gilbert Adair, Andrew Lorenz, Chris Gilchrist's, Adrian Levy, David Wickers, Andrew Lorenz Deputy Business Editor, Nicholas Hellen Media Correspondent, Joanne Robertson, Joe Lovejoy, John Parker, Dominic Hobson, Rupert Steiner, Richard, Nigel Roebuck, Jeff Randall City Editor, Harriet Harman, Hugh Pearman, Neil MacLean, Emma Forrest, Christopher Moran, Peter Roebuck, Carey Scott, Joanna Simon, Sophie Grigson, Esmond Bulmer, Sarah Wynter, Stephen Hayward,
... Portland International Mitchell James Search and Selection Ltd. Hartmann & Lotz Infobank International Mitchell James Search and Selection ... 54 and Stephen Griggs, 33: Footwear, £200m (£149m) Felix Grovit, 52: Property and Finance, £200m (£250m) Paul ...
1995 - Gale Group | Sunday Times HA GDA
Abigail K. Suwala, Marius Felix, Dennis Friedel, Damian Stichel, Daniel Schrimpf, Felix Hinz, Ekkehard Hewer, Leonille Schweizer, Hildegard Dohmen, Ute Pohl, Ori Staszewski, Andrey Korshunov, Marco Stein, Thidathip Wongsurawat, Pornsuk Cheunsuacchon, Sith Sathornsumetee, Christian Koelsche, Clinton Turner, Émilie Le Rhun, Angelika Mühlebner, Philippe Schucht, Koray Özduman, Takahiro Ono, Hiroaki Shimizu, Marco Prinz, Till Acker, Christel Herold‐Mende, Tobias Keßler, Wolfgang Wick, David Capper, Pieter Wesseling, Felix Sahm, Andreas von Deimling, Christian Hartmann, David Reuß,
Abstract Oligodendrogliomas are defined at the molecular level by the presence of an IDH mutation and codeletion of chromosomal arms 1p and 19q. In the past, case reports and small studies described gliomas with sarcomatous features arising from oligodendrogliomas, so called oligosarcomas. Here, we report a series of 24 IDH-mutant oligosarcomas from 23 patients forming a distinct methylation class. The tumors were recurrences from prior oligodendrogliomas or developed de novo. Precursor tumors of ...
Tópico(s): Glioma Diagnosis and Treatment
2021 - Springer Science+Business Media | Acta Neuropathologica
A. P. H. Trivelli, F. Paul Liesegang, L. Lumière, A. Seyewek, L. Lumière, A. Seyewek, L. Lumière, A. Seyewetz, L. Lumière, A. Seyewek, K. Martin, Dr. Max Trauk, Otto Pfenninger, Hans Schmidt, Chr. Jensen, Dr. August Köhler, W. Zschokke, Dr. Jaroslav Husnik, Professor J. Hartmann, J. M. Eder, Professor Rud. Namias, Professor Rud. Namias, Professor Rud. Namias, Professor Rud. Namias, Dr. K. Kieser, G. Daur, Professor Arthur W. Unger, Dr. Frik Weigert, Dr. Paul Krük, Prof. Dr. Karl Schaum, A. Saal, Professor A. Albert, Dr. Gotthelf Leimbach, Professor E. Valenta, Johannes Gaedicke, Dr. Leopold Freund, A. Von Obermayer, C. Kampmann, K. K. Lehrer, A. Edl. Von Obermayer, Dr. Georg Hauberriker, Professor E. Valenta, L. Tschörner,
Frontmatter: Jahrbuch for Photographie and Reproduktionstechnik Für Das Jahr 1909, Jahrbuch for Photographie Und Reproduktionstechnik Für Das Jahr 1909, ...
1909 - Gale Group | NCCO Photography
Rouzbeh Banan, Damian Stichel, Anja C. Bleck, Bujung Hong, Ulrich Lehmann, Abigail K. Suwala, Annekathrin Reinhardt, Daniel Schrimpf, Rolf Buslei, Christine Stadelmann, Karoline Ehlert, Marco Prinz, Till Acker, Jens Schittenhelm, David Kaul, Leonille Schweizer, David Capper, Patrick N. Harter, Nima Etminan, David Jones, Stefan M. Pfister, Christel Herold‐Mende, Wolfgang Wick, Felix Sahm, Andreas von Deimling, Christian Hartmann, David Reuß,
Diffuse IDH-mutant astrocytic tumors are rarely diagnosed in the cerebellum or brainstem. In this multi-institutional study, we characterized a series of primary infratentorial IDH-mutant astrocytic tumors with respect to clinical and molecular parameters. We report that about 80% of IDH mutations in these tumors are of non-IDH1-R132H variants which are rare in supratentorial astrocytomas. Most frequently, IDH1-R132C/G and IDH2-R172S/G mutations were present. Moreover, the frequencies of ATRX-loss ...
Tópico(s): Epigenetics and DNA Methylation
2020 - Springer Science+Business Media | Acta Neuropathologica
A. C. Angerer, Karl Worel, Prof. Dr. E. Wiedemann, Dr. Arthur Slator, Prof. Dr. O. Tumlirz, Dr. A. Pflüger, Dr. R. A. Reiß, Paul Hanneke, K. Martin, L. Lumière, L. Lumière, A. Seyewetz, Prof. J. Elster, Prof. H. Geitel, Prof. Dr. Paul Czermak, J. M. Eder, Dr. R. Neuhauß, W. Zschokke, Max Loehr, Max Loehr, Dr. Georg Hauberrißer, Prof. Dr. G. Aarland, Dr. Fritz Weigert, V. Grünberg, J. M. Eder, Prof. Dr. J. Hartmann, Dr. G. Eberhard, Professor Karl Schaum, Dr. A. Elschnig, Dr. R. Abegg, C. Metz, Franz Novak, K. K. Graphischen Lehr, Prof. A. Albert, Professor R. Namias, Professor R. Namias, Prof. E. Valenta, Professor L. Pfaundler, C. Kampmann, William Gamble, Eduard Kuchinka, Eduard Dolezal, Gottlieb Marktanner-Turneretscher, Arthur W. Unger, Dr. Wilh. Vaubel, Dr. Leopold Freund, A. Freiherrn Von Hübl, L. Tschörner, Dr. Theodor Dokulil, H. Kessler, H. D'arcy-Power, Dr. Jaroslav Husnik, Wilhelm Urbau, Prof. Dr. K. Kaßuer, A. Hoffmann,
... Spezialverlag Für Photographie, Halle A. S., Bromsilber=Papiere, Felix Schoeller Jr, Vorm. Ernst Herbst & Firl Görlitz, P & ...
1905 - Gale Group | NCCO Photography
Abigail K. Suwala, Damian Stichel, Daniel Schrimpf, Matthias Kloor, Annika K. Wefers, Annekathrin Reinhardt, Sybren L. N. Maas, Christian P. Kratz, Leonille Schweizer, Martin Hasselblatt, Matija Snuderl, Malak Abedalthagafi, Zied Abdullaev, Camelia M. Monoranu, Markus Bergmann, Arnulf Pekrun, Christian F. Freyschlag, Eleonora Aronica, Christof M. Kramm, Felix Hinz, Philipp Sievers, Andrey Korshunov, Marcel Kool, Stefan M. Pfister, Dominik Sturm, David Jones, Wolfgang Wick, Andreas Unterberg, Christian Hartmann, Andrew Dodgshun, Uri Tabori, Pieter Wesseling, Felix Sahm, Andreas von Deimling, David Reuß,
Abstract Diffuse IDH-mutant astrocytoma mostly occurs in adults and carries a favorable prognosis compared to IDH-wildtype malignant gliomas. Acquired mismatch repair deficiency is known to occur in recurrent IDH-mutant gliomas as resistance mechanism towards alkylating chemotherapy. In this multi-institutional study, we report a novel epigenetic group of 32 IDH-mutant gliomas with proven or suspected hereditary mismatch repair deficiency. None of the tumors exhibited a combined 1p/19q deletion. ...
Tópico(s): Cancer Genomics and Diagnostics
2020 - Springer Science+Business Media | Acta Neuropathologica
David Capper, David Reuß, Jens Schittenhelm, Christian Hartmann, Juliane Bremer, Felix Sahm, Patrick N. Harter, Astrid Jeibmann, Andreas von Deimling,
Tópico(s): Vascular Malformations Diagnosis and Treatment
2010 - Springer Science+Business Media | Acta Neuropathologica
David Capper, Felix Sahm, Christian Hartmann, Richard Meyermann, Andreas von Deimling, Jens Schittenhelm,
Differentiation of gliomas and reactive gliosis may be challenging both at primary tumor occurrence and at posttherapy biopsy. The most frequent IDH1 mutation found in the majority of WHO grade II and III gliomas can be visualized with an antibody specifically detecting mutant IDH1R132H protein. In this study, mIDH1R132H immunoreactivity in 120 reactive gliosis specimens of various etiologies is compared with Wilms Tumor 1 (WT1) and p53 expression, both markers applied for the differentiation of ...
Tópico(s): RNA Research and Splicing
2010 - Lippincott Williams & Wilkins | The American Journal of Surgical Pathology
Yasunori Sato, Kenichi Harada, Motoko Sasaki, Takahiro Yasaka, Yasuni Nakanuma,
... Google Scholar, 8Melle C. Ernst G. Escher N. Hartmann D. Schimmel B. Bleul A. Thieme H. Kaufmann R. Felix K. Friess H.M. Settmacher U. Hommann M. Richter K.K. Daffner W. Taubig H. Manger T. Claussen U. von Eggeling F. Protein profiling of microdissected pancreas carcinoma ... pancreatic cancer.8Melle C. Ernst G. Escher N. Hartmann D. Schimmel B. Bleul A. Thieme H. Kaufmann R. Felix K. Friess H.M. Settmacher U. Hommann M. Richter K.K. Daffner W. Taubig H. Manger T. Claussen U. von Eggeling F. Protein profiling of microdissected pancreas carcinoma ...
Tópico(s): Pediatric Hepatobiliary Diseases and Treatments
2011 - Elsevier BV | American Journal Of Pathology
Felix von Podewils, Sabine Lapp, Irène Wang, Ute Hartmann, R Herzer, Christof Kessler, Uwe Runge,
The spontaneous course of idiopathic generalized epilepsy (IGE) is still controversial. The aim of this study was both to investigate the long-term spontaneous course and to identify factors that are predictive for epilepsy remission in a small cohort of 15 IGE patients (9 women) who refused antiepileptic drug (AED) treatment and therefore never have been treated with AED. All of them were reevaluated with a review of their medical records and direct face-to-face interview; the mean duration of follow- ...
Tópico(s): Pharmacological Effects and Toxicity Studies
2014 - Elsevier BV | Epilepsy Research
Stefan Pusch, Felix Sahm, Jochen Meyer, Michel Mittelbronn, Christian Hartmann, Andreas von Deimling,
Neuropathology and Applied NeurobiologyVolume 37, Issue 4 p. 428-430 Scientific correspondence S. Pusch, S. Pusch Clinical Cooperation Unit Neuropathology, German Cancer Research CenterSearch for more papers by this authorF. Sahm, F. Sahm Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-University Heidelberg, HeidelbergSearch for more papers by this authorJ. Meyer, J. Meyer Clinical Cooperation Unit Neuropathology, German Cancer Research CenterSearch for more papers by this authorM. ...
Tópico(s): Meningioma and schwannoma management
2010 - Wiley | Neuropathology and Applied Neurobiology
Nathalie Rohmann, Kristina Schlicht, Corinna Geisler, Tim Hollstein, Carina Knappe, Laura Krause, Stefanie Hagen, Alexia Beckmann, Anna Katharina Seoudy, Felix Braun, Katharina Hartmann, Dominik M. Schulte, Kathrin Türk, Jan Beckmann, Witigo von Schönfels, Franziska A. Hägele, Anja Bosy‐Westphal, André Franke, Stefan Schreiber, Matthias Laudes,
Abstract Context Dipeptidylpeptidase (DPP)-4 is a key regulator of the incretin system. It exists in a membrane-bound form and a soluble form (sDPP-4). Initial human studies suggested sDPP-4 to be an adipokine involved in metabolic inflammation. However, recent mechanistic data in genetically modified mice has questioned these findings. Objectives We examined circulating sDPP-4 in a cohort of n = 451 humans with different metabolic phenotypes and during 3 different weight loss interventions (n = 101) to ...
Tópico(s): Neuropeptides and Animal Physiology
2020 - Oxford University Press | The Journal of Clinical Endocrinology & Metabolism
Martina Ott, Ulrike Litzenburger, Felix Sahm, Katharina J. Rauschenbach, Ruxandra Tudoran, Christian Hartmann, Víctor E. Márquez, Andreas von Deimling, Wolfgang Wick, Michael Platten,
Enhancer of zeste homolog 2 (EZH2) is the catalytic subunit of the Polycomb-repressive complex 2 (PRC2) that epigenetically silences gene transcription through histone H3 lysine trimethylation (H3K27me3). EZH2 has been implicated in stem cell maintenance and is overexpressed in hematological and solid malignancie`s including malignant glioma. EZH2 is thought to promote tumor progression by silencing tumor suppressor genes. Hence pharmacological disruption of the PRC2 is an attractive therapeutic strategy ...
Tópico(s): Renal and related cancers
2012 - Public Library of Science | PLoS ONE
Thilo von Groote, Felix Albert, Melanie Meersch, Raphael Koch, Christian Porschen, Oliver Hartmann, Deborah Bergmann, Peter Pickkers, Alexander Zarbock,
Renal replacement therapy (RRT) remains the key rescue therapy for critically ill patients with severe acute kidney injury (AKI). However, there are currently no tools available to predict successful liberation from RRT. Biomarkers may allow for risk stratification and individualization of treatment strategies. Proenkephalin A 119-159 (penKid) has been suggested as a promising marker of kidney function in the context of AKI, but has not yet been evaluated for RRT liberation in critically ill patients ...
Tópico(s): Cardiac Arrest and Resuscitation
2022 - BioMed Central | Critical Care
F. Kommoss, Kenneth Tou En Chang, Damian Stichel, Ana Banito, David Jones, Christoph E. Heilig, Stefan Fröhling, Felix Sahm, Albrecht Stenzinger, Wolfgang Hartmann, Gunhild Mechtersheimer, Hans‐Peter Sinn, Dietmar Schmidt, Friedrich Kommoss, Andreas von Deimling, Christian Koelsche,
Abstract Recently a novel subtype of endometrial stromal sarcoma (ESS) defined by recurrent genomic alterations involving BCOR has been described (HGESS‐BCOR). We identified a case of HGESS‐BCOR with a ZC3H7B‐BCOR gene fusion, which harbored an amplification of the MDM2 locus. This index case prompted us to investigate MDM2 amplification in four additional cases of HGESS‐BCOR. Tumors were analyzed for MDM2 amplification by array‐based profiling of copy number alterations (CNAs) and fluorescence in ...
Tópico(s): Endometrial and Cervical Cancer Treatments
2020 - Wiley | The Journal of Pathology Clinical Research
Produção Nacional
Revisado por pares
Helen Vargas Laitano, Amanda Ely, Anne Orgler Sordi, Felipe Barreto Schuch, Flávio Pechansky, Thiago Casarin Hartmann, Juliana Balbinot Hilgert, Eliana Wendland, Lisia Von Dimen, Juliana Nichterwitz Scherer, Alessandra Mendes Calixto, Joana Corrêa de Magalhães Narvaez, Felipe Ornell, Félix Henrique Paim Kessler,
Conduct a systematic review and meta-analysis to evaluate levels of anger among substance users compared to non-user controls and to analyze the possible association between anger and psychoactive substance use (PSU).The procedures of this review followed the Meta-Analyzes of Observational Studies in Epidemiology (MOOSE) and Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Four electronic databases (MEDLINE, EMBASE, BIREME, PsycINFO) were searched.Twelve studies ...
Tópico(s): Mental Health Research Topics
2021 - Associação Brasileira de Psiquiatria | Brazilian Journal of Psychiatry
Alex Straumann, Alfredo J. Lucendo, Stephan Miehlke, Michael Vieth, Christoph Schlag, Luc Biedermann, Cecílio Santander, Constanza Ciriza de los Ríos, Christoph Schmoecker, Ahmed Madisch, Petr Hrúz, Jamal Hayat, Ulrike von Arnim, Albert J. Bredenoord, Stefan Schubert, Ralph Müeller, Roland Greinwald, Alain Schoepfer, Stephen Attwood, Jan Tack, Stephan Miehlke, Monther Bajbouj, Stefan Brückner, Christiane Fibbe, Sebastian Haag, Christoph Schmöcker, Dirk Hartmann, Frank Lammert, Ahmed Madisch, Max Reinshagen, Stefan Schubert, Ulrike von Arnim, Norbert Börner, Dieter Witzemann, Karel Caca, Jörg Albert, Stefan Zeuzem, Felix Wiedbrauck, Helmut Messmann, Albert J. Bredenoord, Robert C. Verdonk, Franciscus Wolfhagen, Alfredo Lucendo Villarin, Cecílio Santander, Constanza Ciriza de los Ríos, Antonia Perelló Juan, Isabel Pérez‐Martínez, Joaquín Rodríguez Sánchez-Migallón, Jesús Barrio, ÁngelesPérez Aisa, Alex Straumann, Petr Hrúz, Alain Schoepfer, Luc Biedermann, Jamal Hayat, Anjan Dhar,
Eosinophilic esophagitis (EoE) is a chronic inflammatory disorder. Swallowed topical-acting corticosteroids are effective in bringing active EoE into remission. However, it is not clear whether these drugs are effective for long-term maintenance of remission.We performed a double-blind trial to compare the efficacy and safety of 2 dosages of a budesonide orodispersible tablet (BOT) vs placebo in maintaining remission of EoE. Maintenance of remission was defined as absence of clinical and histologic ...
Tópico(s): Eosinophilic Disorders and Syndromes
2020 - Elsevier BV | Gastroenterology
Christian Melle, Günther Ernst, Niko Escher, Daniel Hartmann, Bettina Schimmel, Annett Bleul, Heike Thieme, Roland Kaufmann, Klaus Felix, Helmut Frieß, Utz Settmacher, Merten Hommann, Konrad Klaus Richter, Wolfgang Daffner, Horst Täubig, Thomas Manger, Uwe Claussen, Ferdinand von Eggeling,
Abstract Background: Patients with pancreatic adenocarcinomas have a poor prognosis because of late clinical manifestation and the tumor’s aggressive nature. We used proteomic techniques to search for markers of pancreatic carcinoma. Methods: We performed protein profiling of microdissected cryostat sections of 9 pancreatic adenocarcinomas and 10 healthy pancreatic tissue samples using ProteinChip technology (surface-enhanced laser desorption/ionization). We identified proteins by use of 2-dimensional ...
Tópico(s): Endoplasmic Reticulum Stress and Disease
2007 - American Association for Clinical Chemistry | Clinical Chemistry
Felix Sahm, Christian Koelsche, Jochen Meyer, Stefan Pusch, Kerstin Lindenberg, Wolf Mueller, Christel Herold‐Mende, Andreas von Deimling, Christian Hartmann,
Tópico(s): Drug Transport and Resistance Mechanisms
2012 - Springer Science+Business Media | Acta Neuropathologica
Laurent M. Willems, Felix Rosenow, Susanne Schubert‐Bast, Gerhard Kurlemann, Johann Philipp Zöllner, Thomas Bast, Astrid Bertsche, U Bettendorf, Daniel Ebrahimi‐Fakhari, Janina Grau, Andreas Hahn, Hans Hartmann, Christoph Hertzberg, Frauke Hornemann, Ilka Immisch, Julia Jacobs, Karl Martin Klein, Kerstin Alexandra Klotz, Gerhard Kluger, Susanne Knake, Markus Knuf, Klaus Marquard, Patrick May, Sascha Meyer, Hiltrud Muhle, Karen Müller‐Schlüter, Felix von Podewils, Susanne Ruf, Matthias Sauter, Hannah Schäfer, Jan-Ulrich Schlump, Steffen Syrbe, Charlotte Thiels, Regina Trollmann, Adelheid Wiemer‐Kruel, Bernd Wilken, Bianca Zukunft, Adam Strzelczyk,
The approval of everolimus (EVE) for the treatment of angiomyolipoma (2013), subependymal giant cell astrocytoma (2013) and drug-refractory epilepsy (2017) in patients with tuberous sclerosis complex (TSC) represents the first disease-modifying treatment option available for this rare and complex genetic disorder. The objective of this study was to analyse the use, efficacy, tolerability and treatment retention of EVE in patients with TSC in Germany from the patient's perspective. A structured cross- ...
Tópico(s): Tuberous Sclerosis Complex Research
2021 - Adis, Springer Healthcare | CNS Drugs
David R. Ghasemi, Martin Sill, Konstantin Okonechnikov, Andrey Korshunov, Stephen Yip, Peter W. Schütz, David Scheie, A. Kruse, Patrick N. Harter, Marina Kastelan, Marlies Wagner, Christian Hartmann, Julia Benzel, Kendra K. Maaß, Mustafa Khasraw, Ronald Sträter, Christian Thomas, Werner Paulus, Christian P. Kratz, Hendrik Witt, Daisuke Kawauchi, Christel Herold‐Mende, Felix Sahm, Sebastian Brandner, Marcel Kool, David Jones, Andreas von Deimling, Stefan M. Pfister, David Reuß, Kristian W. Pajtler,
Spinal ependymal tumors form a histologically and molecularly heterogeneous group of tumors with generally good prognosis. However, their treatment can be challenging if infiltration of the spinal cord or dissemination throughout the central nervous system (CNS) occurs and, in these cases, clinical outcome remains poor. Here, we describe a new and relatively rare subgroup of spinal ependymal tumors identified using DNA methylation profiling that is distinct from other molecular subgroups of ependymoma. ...
Tópico(s): Neurofibromatosis and Schwannoma Cases
2019 - Springer Science+Business Media | Acta Neuropathologica
Adam Strzelczyk, Janina Grau, Thomas Bast, Astrid Bertsche, U Bettendorf, Andreas Hahn, Hans Hartmann, Christoph Hertzberg, Frauke Hornemann, Ilka Immisch, Julia Jacobs, Kerstin Alexandra Klotz, Gerhard Kluger, Susanne Knake, Markus Knuf, Gerhard Kurlemann, Klaus Marquard, Patrick May, Sascha Meyer, Hiltrud Muhle, Karen Müller‐Schlüter, Felix von Podewils, Felix Rosenow, Susanne Ruf, Matthias Sauter, Hannah Schäfer, Jan-Ulrich Schlump, Susanne Schubert‐Bast, Steffen Syrbe, Charlotte Thiels, Regina Trollmann, Adelheid Wiemer‐Kruel, Bernd Wilken, Bianca Zukunft, Johann Philipp Zöllner,
Objective Seizures are a primary and early disease manifestation of Tuberous Sclerosis Complex (TSC). We aimed to describe the age-stratified patterns of antiseizure drug (ASD) treatments among children, adolescents, and adults with TSC in Germany. Additionally, we reviewed real-world and clinical study evidence regarding ASD utilization in patients with TSC.Methods We evaluated the pattern of routine ASD use and everolimus prescriptions based on a 2019 multicenter survey of 268 individuals with TSC- ...
Tópico(s): Polyomavirus and related diseases
2021 - Taylor & Francis | Expert Review of Clinical Pharmacology
Felix Sahm, David Capper, Jochen Meyer, Christian Hartmann, Esther Herpel, Mindaugas Andrulis, Gunhild Mechtersheimer, Iver Petersen, Werner Paulus, Andreas von Deimling,
Sahm F, Capper D, Meyer J, Hartmann C, Herpel E, Andrulis M, Mechtersheimer G, Petersen I, Paulus W & von Deimling A(2011) Histopathology 58, 1167–1172Immunohistochemical analysis of 1844 human epithelial and haematopoietic tumours and sarcomas for IDH1R132H mutation Aims: Mutations in the isocitrate dehydrogenase 1 gene have been identified recently to play a key role in diffuse astrocytoma and oligodendroglioma as well as in acute myeloid leukaemia. In glioma, IDH1R132H is the most common mutation ...
Tópico(s): Histone Deacetylase Inhibitors Research
2011 - Wiley | Histopathology
Christian Koelsche, Felix Sahm, Adelheid Wöhrer, Astrid Jeibmann, Jens Schittenhelm, Patricia Kohlhof, Matthias Preusser, Bernd Romeike, Hildegard Dohmen‐Scheufler, Christian Hartmann, Michel Mittelbronn, Albert J. Becker, Andreas von Deimling, David Capper,
BRAF V600E mutation and homozygous deletion of CDKN2A (p16) are frequent molecular alterations in pleomorphic xanthoastrocytomas (PXAs). We investigated 49 PXAs for clinical, histological and immunohistochemical characteristics related to BRAF mutation status. BRAF mutation was detected by immunohistochemical assay and DNA sequencing in 38/49 (78%) tumors. All but one PXA located in the temporal lobe harbored a BRAF V600E mutation (23/24; 96%) compared with 10/19 nontemporal PXAs (53%; P = 0.0009). Histological ...
Tópico(s): Ubiquitin and proteasome pathways
2013 - Wiley | Brain Pathology
David Reuß, Yasin Mamatjan, Daniel Schrimpf, David Capper, Volker Hovestadt, Annekathrin Kratz, Felix Sahm, Christian Koelsche, Andrey Korshunov, Adriana Olar, Christian Hartmann, Jaap C. Reijneveld, Pieter Wesseling, Andreas Unterberg, Michael Platten, Wolfgang Wick, Christel Herold‐Mende, Kenneth Aldape, Andreas von Deimling,
The WHO 2007 classification of tumors of the CNS distinguishes between diffuse astrocytoma WHO grade II (A IIWHO2007) and anaplastic astrocytoma WHO grade III (AA III WHO2007). Patients with A II WHO2007 are significantly younger and survive significantly longer than those with AA III WHO2007. So far, classification and grading relies on morphological grounds only and does not yet take into account IDH status, a molecular marker of prognostic relevance. We here demonstrate that WHO 2007 grading performs ...
Tópico(s): Vascular Malformations Diagnosis and Treatment
2015 - Springer Science+Business Media | Acta Neuropathologica
Felix Sahm, David Reuß, Christian Koelsche, David Capper, Jens Schittenhelm, Stephanie Heim, David Jones, Stefan M. Pfister, Christel Herold‐Mende, Wolfgang Wick, Wolf Mueller, Christian Hartmann, Werner Paulus, Andreas von Deimling,
Tópico(s): Meningioma and schwannoma management
2014 - Springer Science+Business Media | Acta Neuropathologica
Christian Koelsche, Daniel Schrimpf, Lars Tharun, Eva Roth, Dominik Sturm, David Jones, Eva‐Kristin Renker, Martin Sill, Annika Baude, Felix Sahm, David Capper, Melanie Bewerunge‐Hudler, Wolfgang Hartmann, Andreas E. Kulozik, Iver Petersen, Uta Flucke, H.W.B. Schreuder, Reinhard Büttner, Marc‐André Weber, Peter Schirmacher, Christoph Plass, Stefan M. Pfister, Andreas von Deimling, Gunhild Mechtersheimer,
Histone 3.3 (H3.3) hotspot mutations in bone tumors occur in the vast majority of giant cell tumors of bone (GCTBs; 96%), chondroblastomas (95%) and in a few cases of osteosarcomas. However, clinical presentation, histopathological features, and additional molecular characteristics of H3.3 mutant osteosarcomas are largely unknown.In this multicentre, retrospective study, a total of 106 conventional high-grade osteosarcomas, across all age groups were re-examined for hotspot mutations in the H3.3 coding ...
Tópico(s): Chromatin Remodeling and Cancer
2017 - Springer Science+Business Media | Clinical Sarcoma Research
Manuel Röhrich, Christian Koelsche, Daniel Schrimpf, David Capper, Felix Sahm, Annekathrin Kratz, Jana Reuss, Volker Hovestadt, David Jones, Melanie Bewerunge‐Hudler, Albert J. Becker, Joachim Weis, Christian Mawrin, Michel Mittelbronn, Arie Perry, Victor-Felix Mautner, Gunhild Mechtersheimer, Christian Hartmann, Ali Fuat Okuducu, Mirko Arp, Marcel Seiz‐Rosenhagen, Daniel Hänggi, Stefanie Heim, Werner Paulus, Jens Schittenhelm, Rezvan Ahmadi, Christel Herold‐Mende, Andreas Unterberg, Stefan M. Pfister, Andreas von Deimling, David Reuß,
Tópico(s): Neuroblastoma Research and Treatments
2016 - Springer Science+Business Media | Acta Neuropathologica