Hong Zhang, Qingmei Li, Jie Sun, Chunyan Wang, Qing Gu, Xiangwei Feng, Bing Du, Wei Wang, Xiaodong Shi, Siqi Zhang, Wanyu Li, Yanfang Jiang, Junyan Feng, Shumei He, Junqi Niu,
Background and aim:The prevalence of the hepatitis B virus (HBV) is higher in adults than in children.We determined the seroepidemiology of HBV infection in an adult population in JiLin, China, to guide effective preventive measures.Methods: A cross-sectional serosurvey was conducted throughout JiLin, China.A total of 3833 people was selected and demographic and behavioral information gathered.Serum samples were tested for HBV markers and liver enzymes. Results:The prevalence of the hepatitis B surface ...
Tópico(s): Liver Disease Diagnosis and Treatment
2011 - Ivyspring International Publisher | International Journal of Medical Sciences
Feiyong Jia, Ling Shan, Bing Wang, Honghua Li, Junyan Feng, Zhida Xu, Khaled Saad,
Autism spectrum disorder (ASD) is a common neurodevelopmental disorder caused by complicated interactions between genetic and environmental factors. Clinical trials, including case reports, case–control studies, and a double-blinded randomized clinical study, have suggested that high-dose vitamin D3 regimens may ameliorate the core symptoms of ASD. Vitamin D3 supplementation was effective in about three-quarters of children with ASD. To further investigate the relationship between vitamin D and ASD ...
Tópico(s): Child Nutrition and Feeding Issues
2018 - Taylor & Francis | Nutritional Neuroscience
Junyan Feng, Meinan Wang, Deven R. See, Shiaoman Chao, Youliang Zheng, Xianming Chen,
Stripe rust, caused by Puccinia striiformis f. sp. tritici, is an important disease of wheat worldwide. Exploring new resistance genes is essential for breeding resistant wheat cultivars. PI 182103, a spring wheat landrace originally from Pakistan, has shown a high level of resistance to stripe rust in fields for many years, but genes for resistance to stripe rust in the variety have not been studied. To map the resistance gene(s) in PI 182103, 185 recombinant inbred lines (RILs) were developed from ...
Tópico(s): Bioenergy crop production and management
2018 - American Phytopathological Society | Phytopathology
Yuxi Chen, Puping Liang, Yan Huang, Minyan Li, Xiya Zhang, Chenhui Ding, Junyan Feng, Zhen Zhang, Xueqing Zhang, Yuanzhu Gao, Qinfeng Zhang, Shanbo Cao, Haiyan Zheng, Dan Liu, Zhou Songyang, Junjiu Huang,
Spermatids undergo the final steps of maturation during spermiogenesis, a process that necessitates extensive rearrangement of organelles such as the mitochondria. Male infertility has been linked to mitochondrial disorder, for example, hypospermatogenesis and asthenozoospermia. However, the mechanisms that regulate mitochondrial dynamics during spermiogenesis remain largely unknown. We found the glycerol kinase (Gyk)-like proteins glycerol kinase-like 1 (Gykl1) and glycerol kinase 2 (Gk2) were specifically ...
Tópico(s): CRISPR and Genetic Engineering
2017 - Springer Nature | Cell Discovery
Junyan Feng, Fangjie Yao, Meinan Wang, Deven R. See, Xianming Chen,
Wheat stripe rust, caused by Puccinia striiformis f. sp. tritici, is one of the most serious plant diseases worldwide. Resistant cultivars are the most effective way to control the disease. YrTr1 is an important stripe rust resistance gene that has been used in wheat breeding programs and is represented in the host differential set to identify P. striiformis f. sp. tritici races in the United States. To map YrTr1, AvSYrTr1NIL was backcrossed to its recurrent parent Avocet S (AvS). Seedlings of BC ...
Tópico(s): Genetic Mapping and Diversity in Plants and Animals
2023 - American Phytopathological Society | Plant Disease
Ziqing Yang, Shaomin Zou, Yijing Zhang, Jieping Zhang, Peng Zhang, Lishi Xiao, Yunling Xie, Manqi Meng, Junyan Feng, Liang Kang, Mong‐Hong Lee, Lekun Fang,
Abstract Gastric cancer (GC), one of the most common malignant tumors in the world, exhibits a rapid metastasis rate and causes high mortality. Diagnostic markers and potential therapeutic targets for GCs are urgently needed. Here we show that Actin-like protein 6 A (ACTL6A), encoding an SWI/SNF subunit, is highly expressed in GCs. ACTL6A is found to be critical for regulating the glutathione (GSH) metabolism pathway because it upregulates γ-glutamyl-cysteine ligase catalytic subunit (GCLC) expression, ...
Tópico(s): Cancer, Lipids, and Metabolism
2023 - Nature Portfolio | Nature Communications
Yuxin Zuo, Ying Yu, Junyan Feng, Chuncheng Zuo,
Flexible Al-air batteries have great potential in the field of wearable electronic devices. However, how to reduce the thickness of the battery and improve their applicability in wearable applications is still an unresolved thorny problem. Therefore, this article focuses on the strategies to minimize the thickness of the solid electrolyte for flexible Al-air batteries. In this paper, an innovative aerosol jet printing method is used to prepare the ultrathin neutral electrolyte with a thickness of ...
Tópico(s): Advanced battery technologies research
2022 - Nature Portfolio | Scientific Reports
Hanyu Dong, Junyan Feng, Honghua Li, Xiaojing Yue, Feiyong Jia,
Abstract Background The prevalence of autism spectrum disorder (ASD) has increased rapidly in recent years. Environmental factors may play an important role in the pathogenesis of ASD. These factors may include socioeconomic factors, nutritional factors, heavy metal exposure, air pollution, etc. Our aim is to analyze possible environmental factors associated with the severity of ASD. Methods All participating children were divided into two groups (mild and moderate/severe) according to the severity ...
Tópico(s): Genetics and Neurodevelopmental Disorders
2022 - BioMed Central | BMC Pediatrics
Ling Shan, Junyan Feng, Tiantian Wang, Zhida Xu, Feiyong Jia,
Background Previous studies have mostly explored the comorbidities of Global developmental delay (GDD) in children with Autism Spectrum Disorders (ASD) from the perspective of ASD. The study focus on the perspective of GDD to investigate the prevalence and developmental profiles of ASD in GDD and to explore the correlation between the developmental level and symptoms of autism. Methods Clinical data of 521 children with GDD aged from 24 to 60 months were retrospectively analyzed. Analyses were performed ...
Tópico(s): Child Development and Digital Technology
2022 - Frontiers Media | Frontiers in Psychiatry
Shaomin Zou, Baifu Qin, Ziqing Yang, Wencong Wang, Jieping Zhang, Yijing Zhang, Manqi Meng, Junyan Feng, Yunling Xie, Ling Fang, Lishi Xiao, Peng Zhang, Xiangqi Meng, Hyun Ho Choi, Weijie Wen, Qihao Pan, Bart Ghesquière, Ping Lan, Mong‐Hong Lee, Lekun Fang,
Abstract Metabolic reprogramming can contribute to colorectal cancer progression and therapy resistance. Identification of key regulators of colorectal cancer metabolism could provide new approaches to improve treatment and reduce recurrence. Here, we demonstrate a critical role for the COP9 signalosome subunit CSN6 in rewiring nucleotide metabolism in colorectal cancer. Transcriptomic analysis of colorectal cancer patient samples revealed a correlation between CSN6 expression and purine and pyrimidine ...
Tópico(s): Cancer, Hypoxia, and Metabolism
2022 - American Association for Cancer Research | Cancer Research
Jing Hua, Anna L. Barnett, Gareth J. Williams, Xiaotian Dai, Yuanjie Sun, Haifeng Li, Guixia Chen, Lei Wang, Junyan Feng, Yingchun Liu, Lan Zhang, Ling Zhu, Tingting Weng, Hongyan Guan, Yue Gu, Yingchun Zhou, Andrew Timothy Butcher, Wenchong Du,
Importance It remains unknown whether children born at different degrees of prematurity, early term, and post term might have a higher risk of developmental coordination disorder (DCD) compared with completely full-term children (39-40 gestational weeks). Objective To differentiate between suspected DCD in children with different gestational ages based on a national representative sample in China. Design, Setting, and Participants A retrospective cohort study was conducted in China from April 1, 2018, to December ...
Tópico(s): Family and Disability Support Research
2021 - American Medical Association | JAMA Network Open
Hanyu Dong, Junyan Feng, Bing Wang, Ling Shan, Feiyong Jia,
Objective: To investigate the current status of screen time in children with ASD, its correlation with autistic symptoms and developmental quotient (DQ), and the factors affecting screen time. Method: One hundred ninety-three Chinese children with ASD were recruited. We collected the demographic and screen time data using a questionnaire. The ASD core symptoms and developmental quotient (DQ) were measured by the Autism Behavior Checklist (ABC), Childhood Autism Rating Scale (CARS), Autism Diagnostic ...
Tópico(s): Impact of Technology on Adolescents
2021 - Frontiers Media | Frontiers in Psychiatry
Zhiyao Zhao, Zexiong Su, Puping Liang, Di Liu, Shuai Yang, Yaoxing Wu, Ling Ma, Junyan Feng, Xiya Zhang, Chenglei Wu, Junjiu Huang, Jun Cui,
Adv. Sci. 2020, 7, 2002680 DOI: 10.1002/advs.202002680 In the originally published article, the same figure for Figure S3 A and B were shown (Supporting Information). Please find the correct Figure S3 here: The authors apologize for any inconvenience this may have caused.
Tópico(s): Ubiquitin and proteasome pathways
2021 - Wiley | Advanced Science
Zhiyao Zhao, Zexiong Su, Puping Liang, Di Liu, Shuai Yang, Yaoxing Wu, Ling Ma, Junyan Feng, Xiya Zhang, Chenglei Wu, Junjiu Huang, Jun Cui,
Chromatin modifications, such as histone acetylation, ubiquitination, and methylation, play fundamental roles in maintaining chromatin architecture and regulating gene transcription. Although their crosstalk in chromatin remodeling has been gradually uncovered, the functional relationship between histone ubiquitination and methylation in regulating immunity and inflammation remains unclear. Here, it is reported that USP38 is a novel histone deubiquitinase that works together with the histone H3K4 ...
Tópico(s): interferon and immune responses
2020 - Wiley | Advanced Science
Honghua Li, Chengxin Wang, Junyan Feng, Bing Wang, Chun-Li Li, Feiyong Jia,
The purpose of this study was to profile the mental development of children aged 18 to 96 months with autism spectrum disorder (ASD) using the Chinese version of the Griffiths Mental Development Scales (GMDS), and to explore the relationships between developmental levels and ASD severity, the sex of the child and the age of ASD diagnosis. Children with ASD (n = 398; 337 boys, 61 girls) were recruited and ASD severity evaluated using the Autism Behavior Checklist and the Childhood Autism Rating Scale, ...
Tópico(s): Family and Disability Support Research
2020 - Frontiers Media | Frontiers in Psychology
Honghua Li, Junyan Feng, Bing Wang, Yu Zhang, Chengxin Wang, Feiyong Jia,
Background: The newly revised Children Neuropsychological and Behavior Scale (CNBS-R2016) is a diagnostic assessment tool widely used in China to assess the developmental level of children aged 0 to 6 years. The purpose of this study was to determine whether the effectiveness of developmental assessment in children with autism spectrum disorder (ASD) by the CNBS-R2016 was consistent with that of the Griffiths Mental Development Scales for China (GDS-C). Methods: In total, 139 children with ASD were ...
Tópico(s): Child Nutrition and Feeding Issues
2019 - Dove Medical Press | Psychology Research and Behavior Management
Ming Li, Songtao Yang, Wei Xu, Zhigang Pu, Junyan Feng, Zhangying Wang, Cong Zhang, Meifang Peng, Chunguang Du, Feng Lin, Changhe Wei, Shuai Qiao, Hongda Zou, Lei Zhang, Yan Li, Huan Yang, Anzhong Liao, Wei Song, Zhongren Zhang, Ji Li, Kai Wang, Yizheng Zhang, Honghui Lin, Jinbo Zhang, Wenfang Tan,
Sweetpotato (Ipomoea batatas (L.) Lam.) is the seventh most important crop in the world and is mainly cultivated for its underground storage root (SR). The genetic studies of this species have been hindered by a lack of high-quality reference sequence due to its complex genome structure. Diploid Ipomoea trifida is the closest relative and putative progenitor of sweetpotato, which is considered a model species for sweetpotato, including genetic, cytological, and physiological analyses.Here, we generated ...
Tópico(s): Cocoa and Sweet Potato Agronomy
2019 - BioMed Central | BMC Plant Biology
Honghua Li, Zhida Xu, Bing Wang, Junyan Feng, Hanyu Dong, Feiyong Jia,
Purpose: Vitamin D deficiency has been found in children with chronic tic disorders (CTDs). Our previous data showed that serum 25-hydroxyvitamin D [25(OH)D] level in children with CTDs was lower than that of the healthy controls and lower serum 25(OH)D level was associated with increased severity of the tic disorder. Thus, we intend to further verify this phenomenon and examine the effect of vitamin D3 on CTDs. Patients and methods: In total, 120 children with CTDs and 140 normal controls were enrolled ...
Tópico(s): Child Nutrition and Feeding Issues
2019 - Dove Medical Press | Neuropsychiatric Disease and Treatment
Junyan Feng, Shan Zhao, Ming Li, Cong Zhang, Huijuan Qu, Qing Li, Jianwei Li, Lin Yang, Zhigang Pu,
Sweetpotato (Ipomoea batatas L.) is one of the most important food and grain-forage crops globally. It has been planted in >100 countries. Due to the complexity of the sweetpotato genome, its research is far behind other major food crops. At present, limited information about the sweetpotato genome is available. Thus, it is central to find an efficient approach for the investigation of sweetpotato genome. In this study, RAD-seq (Restriction site-associated DNA sequencing) was used to evaluate sweetpotato ...
Tópico(s): Cocoa and Sweet Potato Agronomy
2019 - Elsevier BV | Genomics
Feiyong Jia, H Dong, Xinmei Jiang, Chunbo Niu, Lin Du, Junyan Feng,
To examine the effects of Cerebrolysin on the treatment of diabetic peripheral neuropathy, we first established a mouse model of type 2 diabetes mellitus by administering a high-glucose, high-fat diet and a single intraperitoneal injection of streptozotocin. Mice defined as diabetic in this model were then treated with 1.80, 5.39 or 8.98 mL/kg of Cerebrolysin via intraperitoneal injections for 10 consecutive days. Our results demonstrated that the number, diameter and area of myelinated nerve fibers ...
Tópico(s): Pharmacology and Obesity Treatment
2016 - Medknow | Neural Regeneration Research
Tiantian Wang, Lin Du, Ling Shan, Hanyu Dong, Junyan Feng, Maren C. Kiessling, Nicholas B. Angstman, Christoph Schmitz, Fei-Yong Jia,
To assess the effects of radial extracorporeal shock wave therapy (rESWT) on plantar flexor muscle spasticity and gross motor function in very young patients with cerebral palsy (CP).The design was case-control study (level of evidence 3).The setting was the Department of Pediatric Neurology and Neurorehabilitation, First Hospital of Jilin University, Changchun, China.Those with a diagnosis of CP and spastic plantar flexor muscles were recruited between April 2014 and April 2015.According to the parents' ...
Tópico(s): Tendon Structure and Treatment
2016 - Wolters Kluwer | Medicine
Junyan Feng, Ling Shan, Lin Du, Bing Wang, Honghua Li, Wei Wang, Tiantian Wang, Hanyu Dong, Xiaojing Yue, Zhida Xu, Wouter Staal, Feiyong Jia,
High prevalence of vitamin D deficiency was previously reported in children with Autism Spectrum Disorder (ASD), but little is known about the efficacy of vitamin D3 treatment in ASD, although data from pilot studies seem promising. We hypothesized that serum vitamin D levels are reduced in ASD and correlate with the severity of disease. Also, we hypothesized that vitamin D3 treatment may be beneficial for a considerable portion of children with ASD.In total, 215 children with ASD and 285 healthy ...
Tópico(s): Attention Deficit Hyperactivity Disorder
2016 - Taylor & Francis | Nutritional Neuroscience
Tiantian Wang, Ling Shan, Lin Du, Junyan Feng, Zhida Xu, Wouter Staal, Feiyong Jia,
Tópico(s): Vitamin D Research Studies
2015 - Springer Science+Business Media | European Child & Adolescent Psychiatry
Pingwei Zhao, Xu Shi, Cong Li, Desalegn Admassu Ayana, Junqi Niu, Junyan Feng, Juan Wang, Yanfang Jiang,
This study aimed to investigate the potential effect of interleukin 33 (IL-33) on humoral responses to hepatitis B virus (HBV) and the possible mechanisms underlying the action of IL-33 in regulating follicular helper T (TFH) cells. The impact of IL-33 treatment on the levels of serum HBV DNA, HBsAg, HBeAg, HBsAb, and HBeAb, as well as the frequencies of CD4+CXCR5+ TFH cells in wild-type HBV transgenic (HBV-Tg) mice and in a transwell coculture of HepG2.2.15 with IL-33-treated peripheral blood mononuclear ...
Tópico(s): T-cell and B-cell Immunology
2015 - Mary Ann Liebert, Inc. | Journal of Interferon & Cytokine Research
Junyan Feng, Guoyue Chen, Yuming Wei, Yaxi Liu, Qiantao Jiang, Wei Li, Zhien Pu, Xiujin Lan, Shoufen Dai, Youliang Zheng,
Tópico(s): Genetics and Plant Breeding
2013 - Springer Science+Business Media | Molecular Breeding
Juan Wang, Pingwei Zhao, Hui Guo, Xiguang Sun, Zhenyu Jiang, Lijun Xu, Junyan Feng, Junqi Niu, Yanfang Jiang,
Interleukin-33 (IL-33) is associated with the development of Th2 responses. This study examined the potential role of IL-33 in the pathogenic process of chronic hepatitis C (CHC) in Chinese patients. The levels of serum IL-33 and sST2 in 154 patients with CHC, 24 with spontaneously resolved HCV (SR-HCV) infection and 20 healthy controls (HC), were analyzed by ELISA. The concentrations of serum IL-2, IFN-γ, TNF-α, IL-4, IL-6, and IL-10, HCV loads, ALT, AST, and HCV-Ab were measured. We found that the ...
Tópico(s): Immune Cell Function and Interaction
2012 - Hindawi Publishing Corporation | Mediators of Inflammation
Hui Guo, Bingchuan Xu, Lichao Gao, Xiguang Sun, Xiaozhang Qu, Xiaowei Li, Shumei Liu, Junyan Feng, Juan Wang, Ying Tang, Guoqiang Yan, Xiuzhu Gao, Yanfang Jiang,
Chronic low-grade inflammation is crucial for the development of insulin resistance and type 2 diabetes mellitus (T2DM), and immunocompetent cells, such as T-cells, B-cells, mast cells and macrophages, regulate the pathogenesis of T2DM. However, little is known about the role of natural killer (NK) and natural killer T (NKT) cells in the pathogenic process of T2DM. A total of 16 patients with new onset T2DM and nine healthy subjects were recruited, and the frequency of peripheral blood activated and ...
Tópico(s): IL-33, ST2, and ILC Pathways
2012 - SAGE Publishing | Experimental Biology and Medicine
Juan Wang, Yanjun Cai, Huifan Ji, Junyan Feng, Desalegn Admassu Ayana, Junqi Niu, Yanfang Jiang,
This aim of this study was to assess the potential role of IL-33 in the pathogenic process of chronic hepatitis B (CHB). The levels of serum IL-33 and soluble ST2 (sST2) in CHB patients and healthy controls (HC) were determined using enzyme-linked-immunosorbent serologic assay, and the Th1 (IFN-γ, TNF-α, IL-2) and Th2 (IL-4, IL-6, IL-10) cytokines by cytometric bead array. It was found that the levels of serum IL-33 in CHB patients were significantly higher than that of HC at the base line, but decreased ...
Tópico(s): Eosinophilic Esophagitis
2012 - Mary Ann Liebert, Inc. | Journal of Interferon & Cytokine Research
Liang Ma, Yanjun Cai, Lei Yu, Junyan Feng, Juan Wang, Cong Li, Junqi Niu, Yanfang Jiang,
ABSTRACT Chronic infection with hepatitis B virus (HBV) is associated with impairment of T and NK cell immunity. This study was aimed at investigating the impact of treatment with telbivudine (LDT) on T and NK cell immunity in patients with chronic hepatitis B (CHB). A total of 54 CHB patients and 30 healthy controls (HC) were recruited. Individual patients were treated orally with 600 mg LDT daily for 13 months. The serum HBV DNA loads, the levels of the HBV-related biomarkers alanine aminotransferase ( ...
Tópico(s): Hepatitis C virus research
2012 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
Junyan Feng, Xiaoli Hu, Hui Guo, Xiguang Sun, Juan Wang, Lijun Xu, Zhenyu Jiang, Bingchuan Xu, Junqi Niu, Yanfang Jiang,
Tópico(s): Hepatitis B Virus Studies
2012 - Springer Science+Business Media | Journal of Gastroenterology