Stephen N. Steen, Robert N. Smith, Josephine Kuo, Irwin Ziment, Gildon N. Beall,
Aerosolized fenoterol in a dosage of 400 µg was compared to isoproterenol 150 µg in 31 asthmatic subjects during ... and 90. Analysis of the data revealed that fenoterol consistently produced a significantly greater increase in FEV1, ... baseline for over three hours after use of fenoterol and for only one hour after use of isoproterenol. Fenoterol had less effect upon the cardiovascular and central ... incidence of shaking compared to isoproterenol. Patients used fenoterol less frequently than isoproterenol which can be attributed ...
Tópico(s): Advanced Chemical Sensor Technologies
1977 - Elsevier BV | CHEST Journal
Stephen N. Steen, Robert J. Smith, Josephine Kuo, Irwin Ziment, Gildon Beall,
Fenoterol hydrobromide (Berotec; formerly Th 1165a) is a sympathomimetic bronchodilator drug. Twenty subjects with mild to moderate ... mg, 7.5 mg, and 10 mg of fenoterol hydrobromide, 24 mg of ephedrine, and placebo. Spirometric ... effects (eg, shakiness, nervousness) were minimal. Administration of fenoterol resulted in bronchodilation; a peak effect was noted ... relationship was observed; therapy with 5 mg of fenoterol hydrobromide was superior to placebo and equal to ... of 7.5 mg and 10 mg of fenoterol hydrobromide were significantly better than placebo or ephedrine. ...
Tópico(s): Respiratory and Cough-Related Research
1977 - Elsevier BV | CHEST Journal
Bernard E. Pennock, Robert M. Rogers, Billy R. Ryan, Larry Ayers,
Bronchodilator and side effects of fenoterol hydrobromide (Th1165a; hydroxyphenylorciprenaline; Berotec) and isoproterenol given by inhalation were compared in a double-blind crossover study involving 20 volunteer subjects ... airways. Subjects inhaled medications from aerosol canisters containing fenoterol hydrobromide (0.1 mg, 0.2 mg, or ... specific conductance. The onset of bronchodilation after both fenoterol and isoproterenol was rapid, but the effect from fenoterol lasted much longer, up to eight hours. None ...
Tópico(s): Asthma and respiratory diseases
1977 - Elsevier BV | CHEST Journal
... bronchodilator and cardiovascular effects of cumulative dose of fenoterol and salbutamol (albuterol) aerosols was carried out in ... no significant difference in the bronchodilator efficacy of fenoterol and salbutamol; though the heart rates after fenoterol were significantly higher than after salbutamol. Ventricular dysrhythmias ... the study in four patients were seen with fenoterol; whereas no significant ventricular dysrhythmias were observed with ... concluded that salbutamol has lesser cardiostimulatory effects than fenoterol. Comparative evaluation of the bronchodilator and cardiovascular effects ...
Tópico(s): Chronic Obstructive Pulmonary Disease (COPD) Research
1980 - Elsevier BV | CHEST Journal
R. Kevin Elwood, R. T. ABBOUD,
We studied the bronchodilator effects of inhaled,fenoterol, a relatively selective beta-2 adrenergic agent, and ipratropium an anticholinergic drug, singly and in combination in IO patients with asthma.The period ... aerosol administration.The six drug regimens used were fenoterol 100 t.Lg, fenoterol 200 Fg, fenoterol 50 pg combined with 20 t.Lg of ipratropium, fenoterol 100 t.Lg combined with 40 pg of ... volumes, and heart rate.Bronchodilation with regimens containing fenoterol was rapid, with 7570 of the maximum response ...
Tópico(s): Pharmacological Effects and Assays
1982 - Elsevier BV | Journal of Allergy and Clinical Immunology
Suetaro Watanabe, William G. Turner, Attilio D. Renzetti, Keith W. Harless, Adelbert H. Bigler, A Cutillo,
... to find the optimal single therapeutic dose of fenoterol inhalant solution administered by compressor-powered nebulization, bronchodilator and side effects of five different doses of fenoterol (0.5, 1.0, 1.5, 2.0, ... in 16 patients with reversible airway obstruction. The fenoterol (except for the metered dose) and the placebo ... manner. In comparison with placebo, all doses of fenoterol produced a significant increase in average values of ... greater and more prolonged with increasing doses of fenoterol. Compared with 0.4 mg given from a ...
Tópico(s): Respiratory and Cough-Related Research
1981 - Elsevier BV | CHEST Journal
Andries S. Koster, G.A. Hofman, Ank Frankhuijzen-Sierevogel, J. Noordhoek,
The intestinal and liver first pass metabolism of fenoterol.HBr (Berotec, Partusisten) was investigated in the conscious rat. Fenoterol plasma concentrations (2-1000 ng/ml) were measured ... HPLC determination using electrochemical detection. After intraduodenal administration, fenoterol was incompletely absorbed (47-66% not absorbed). Presystemic ... the splanchnic region to the systemic clearance of fenoterol was assessed by measuring fenoterol and fenoterol-glucuronide concentrations in arterial and portal ...
Tópico(s): Analytical Methods in Pharmaceuticals
1985 - American Society for Pharmacology and Experimental Therapeutics | Drug Metabolism and Disposition
Peter Frith, Bartosz Jenner, R. Dangerfield, J. P. Atkinson, Catherine L. Drennan,
... inhaler. A comparison was also made between oxitropium, fenoterol (400µg), and a combination of oxitropium (200µg) and fenoterol (400µg). Fenoterol produced a greater degree of maximal bronchodilatation than ... action of oxitropium was greater than that of fenoterol (ie, the forced expiratory volume in one second [ ... no difference between 200µg and 300µg. The oxitropium-fenoterol combination had a rapid onset of action, and ... appears to be 20µg. Addition of oxitropium to fenoterol appears to offer even greater efficacy. The efficacy ...
Tópico(s): Antibiotics Pharmacokinetics and Efficacy
1986 - Elsevier BV | CHEST Journal
Andries S. Koster, Ank C. Frankhuijzen- Sierevogel, Anton Mentrup,
The glucuronidation of fenoterol (Berotec, Partusisten) in isolated rat hepatocytes and enterocytes was investigated. Two different glucuronides, fenoterol para-glucuronide and fenoterol meta-glucuronide, were formed in proportions, that were ... hepatocytes and 0.54 +/- 0.01 for enterocytes. Fenoterol consists of a racemic mixture of SS'(+)fenoterol and RR'(-)fenoterol. The maximum glucuronidation rate of the (-)enantiomer (Vmax = ... 148 +/- 13 and 372 +/- 50 pmol/min/mg [(-)fenoterol in hepatocytes and enterocytes], Vmax = 173 +/- 12 and ...
Tópico(s): Drug Transport and Resistance Mechanisms
1986 - Elsevier BV | Biochemical Pharmacology
Amber Flatt, Carl Burgess, Hugh H. Windom, Richard Beasley, G Purdie, Julian Crane,
... whether oral theophylline potentiated the cardiovascular effects of fenoterol administered by metered-dose inhaler. Eight healthy subjects ... given doses of 400μg, 600μg, and 800μg of fenoterol at 15-minute intervals (total dose, 1.8 ... from placebo. Theophylline potentiated those hemodynamic effects of fenoterol due to enhanced cardiac sympathetic tone (mean±SE) ... PEP and diastolic BP, were not potentiated. Although fenoterol prolonged the Q-Tc interval and decreased T- ... potentiates the positively inotropic and chronotropic effects of fenoterol. We have investigated whether oral theophylline potentiated the ...
Tópico(s): Pharmacological Effects and Assays
1989 - Elsevier BV | CHEST Journal
Stefano Carlone, Elena Angelici, Paolo Palange, Piero Serra, Mark O. Farber,
... drugs, particularly β-adrenergic agonists. In recent years, fenoterol (Berotec), an effective β-adrenergic agonist, has been ... chronic obstructive pulmonary disease (COPD). The effects of fenoterol on systemic hemodynamics or arterial oxygenation (or both) ... transport before and 60 minutes after administration of fenoterol. Studies were performed at rest and after exercise. ... remained statistically unchanged one hour after administration of fenoterol; with exercise, the heart rate, blood pressure, minute ...
Tópico(s): Cardiovascular and exercise physiology
1988 - Elsevier BV | CHEST Journal
Michael Pawlik, Thomas Schubert, Susanne Hopf, Matthias Lubnow, Michael Gruber, Christoph Selig, K. Taeger, Karl Peter Ittner,
... tested the effect of the nebulized beta-agonist fenoterol on lung variables in a rodent model of ... and controlled study, we evaluated the effects of fenoterol inhalation on lung oxygenation, inflammation, and pulmonary histology ... for 6 h and randomized to receive either fenoterol inhalation 10 microg or saline inhalation, both at ... min, and postmortem histology was subsequently examined. Additionally, fenoterol concentrations in bronchoalveolar lavage fluid (BALF) and plasma ... wet/dry ratio.Inhalation treatment with 10 microg fenoterol significantly increased oxygenation after 270 and 360 min ...
Tópico(s): Thermal Regulation in Medicine
2009 - Lippincott Williams & Wilkins | Anesthesia & Analgesia
Peter Bremner, Carl Burgess, Julian Crane, D. J. McHaffie, D. C. Galletly, Neil Pearce, Kate Woodman, Richard Beasley,
... the association of increased risk of death with fenoterol in patients with asthma in New Zealand is ... be a complicating factor. The cardiovascular effects of fenoterol have been investigated therefore under conditions of normoxaemia ... before and after administration of 800 micrograms of fenoterol by a metered dose inhaler. The order in ... to a Latin square design.Before inhalation of fenoterol hypoxaemia was associated with a significant increase in ... interval (15.6 ms). Under conditions of normoxaemia fenoterol caused a significant increase in heart rate (14. ...
Tópico(s): Poisoning and overdose treatments
1992 - BMJ | Thorax
Willem Haasnoot, Piet Stouten, Arjen Lommen, Geert Cazemier, Dick Hooijerink, R. Schilt,
Fenoterol and ractopamine are phenethanolamines with β-adrenergic agonist activity. An enzyme immunoassay (EIA) for these compounds ... raised in a New Zealand white rabbit against fenoterol–bovine serum albumin and fenoterol coupled to horseradish peroxidase (HRP). The calibration graphs of fenoterol and ractopamine showed linearity over the concentration ranges ... 1%. The screening assay was used to detect fenoterol in urine samples obtained from an animal experiment in which male calves were treated with fenoterol (100 µg of fenoterol per kg of bodymass ...
Tópico(s): Receptor Mechanisms and Signaling
1994 - Royal Society of Chemistry | The Analyst
Richard Beasley, C Burgess, Neil Pearce, Kate Woodman, Julian Crane,
... and one from Saskatchewan, Canada, have found that fenoterol increases the risk of death in patients with ... may be due to confounding by severity, if fenoterol was selectively prescribed to more severe asthmatics. This ‘ ... in whom the case‐control studies were conducted), fenoterol was not preferentially prescribed to the more severe ... was greater co‐prescribing of other drugs with fenoterol (compared with salbutamol) during the later years of ... did not explain the excess risk associated with fenoterol, and there was little evidence of greater co‐ ...
Tópico(s): Pharmacological Effects and Assays
1994 - Wiley | Clinical & Experimental Allergy
Ka‐Pan Lam, Yu‐Te Chu, Min‐Sheng Lee, H. Chen, Weili Wang, Teck‐Siang Tok, Yow‐Yue Chin, Solomon Chih–Cheng Chen, Chang‐Hung Kuo, Chih‐Hsing Hung,
... and Hung CH. Inhibitory Effects of Albuterol and Fenoterol on RANTES and IP‐10 Expression in Bronchial ... also have immunomodulatory function. However, whether albuterol and fenoterol (two SABAs) have modulatory effects on RANTES and ... were pre‐treated with different concentrations of albuterol, fenoterol or dibutyryl‐cAMP (a cyclic AMP analog) before ... β2‐adrenoreceptor antagonist, 30 min before albuterol or fenoterol treatment. The levels of RANTES and IP‐10 ... NF)‐κB inhibitor, and western blot. Albuterol and fenoterol suppressed poly I:C‐induced RANTES and IP‐ ...
Tópico(s): Respiratory and Cough-Related Research
2011 - Wiley | Pediatric Allergy and Immunology
Farideh Beigi, Carlo Bertucci, Weizhong Zhu, Khalid Chakir, Irving W. Wainer, Rui‐Ping Xiao, Darrell R. Abernethy,
Abstract Background: rac‐ Fenoterol is a β 2 ‐adrenoceptor agonist (β 2 ‐AR) used in the treatment of asthma. It has two chiral ... racemic mixture of R , R ′‐ and S , S ′‐fenoterol (R‐F and S‐F). Here we report ... adult rat cardiomyocytes. Results: Chiral chromatography of rac‐ fenoterol yielded separated peaks with an enantioselectivity factor of ... as the stationary phase and rac‐ 3 H‐fenoterol as a marker ligand showed that addition of ... produced concentration‐dependent decreases in rac‐ 3 H‐fenoterol retention, while similar addition of S‐F produced ...
Tópico(s): Protein purification and stability
2006 - Wiley | Chirality
Stéfano Palea, Moèz Rekik, Céline Rouget, Philippe Camparo, Henri Botto, P. Rischmann, Philippe Lluel, Timothy D. Westfall,
Fenoterol has been reported to be a potent and selective β2-adrenoceptor agonist and is currently used ... stimulation of β2-adrenoceptors can inhibit this response, fenoterol was tested against EFS-induced contractions in human ... organ baths and reproducible contractions induced by EFS. Fenoterol was added cumulatively in the presence of the ... ICI118551 or the β3-adrenoceptor antagonist L-748337. Fenoterol inhibited neurogenic contractions in all three species in ... ICI118551 (100 nM) did not affect responses to fenoterol, while L-748337 (0.3–3 μM) produced ...
Tópico(s): Ion Channels and Receptors
2012 - Elsevier BV | European Journal of Pharmacology
Karin Bauer, Franz Dietersdorfer, K Sertl, B Kaik, Gerhard Kaik,
... and hypokalemic effects of single doses of inhalative fenoterol dry powder capsules (0.4 mg) were compared with the fenoterol metered dose inhaler (0.4 mg) and colforsin ( ... potency (mean ± SEM maximum increase from baseline) was fenoterol metered dose inhaler (0.51 ± 0.06 sec−1 · kPa−1), fenoterol dry powder capsules (0.49 ± 0.07), and ... marked increase in finger tremor amplitude resulted after fenoterol metered dose inhaler only (62.93% ± 10.21%; p < 0.05) in contrast to fenoterol dry powder capsules (15.84% ± 4.35%; p < ...
Tópico(s): Pharmacological Effects and Assays
1993 - Wiley | Clinical Pharmacology & Therapeutics
Hiroshi Koyama, Koichi Nishimura, Akihiko Ikeda, Takateru Izumi,
... and cardiovascular effects of oxitropium (0.2 mg), fenoterol (0.4 mg), combined oxitropium and fenoterol (0.2 mg and 0.4 mg, respectively) ... double-blind, placebo-controlled trial. Combined oxitropium and fenoterol produced significantly greater improvements in FEV1 over a ... time-FEV1 curve (AUC) than either oxitropium or fenoterol alone. The effects of oxitropium on both FEV, and AUC values were similar to those of fenoterol. Oxitropium resulted in a greater increase in FEV, ... the placebo even after 10 h. In contrast, fenoterol produced a significant improvement in the FEV, for ...
Tópico(s): Respiratory Support and Mechanisms
1993 - Elsevier BV | CHEST Journal
Junnichi Suzuki, S Suzuki, Takao Okubo,
... studied the effects of a single dose of fenoterol on the relationship between inspiratory effort sensation (IES) ... was scored with a modified Borg scale. Either fenoterol (5 mg) or a placebo was given orally ... double-blind crossover protocol. The endurance time with fenoterol (34.4 +/- 8.6 min) was longer than ... decreased during loading; the decrease was less with fenoterol (P < 0.05). The EMGdi also decreased with loading; the decrease was greater on fenoterol treatment (P < 0.01). The PI,mmax and ... loading in both groups but was lower with fenoterol than with the placebo (P < 0.05). The ...
Tópico(s): Respiratory and Cough-Related Research
1996 - American Physiological Society | Journal of Applied Physiology
Peter Bremner, Robert Siebers, Julian Crane, Richard Beasley, Carl Burgess,
... extrapulmonary effects of the β-agonists albuterol and fenoterol in eight healthy volunteers. Subjects and methods In ... monophosphate [cAMP]) of repeated inhalation of albuterol and fenoterol. In eight healthy volunteers, 400 µg of each ... to produce 50% of the maximum response to fenoterol (ED50F) were calculated. Results The Emax for fenoterol was significantly greater than albuterol for plasma K+ (- ... ED50F was significantly greater for albuterol than for fenoterol with potency ratios of 1.75, 1.61, ... cAMP, respectively. There were no significant differences between fenoterol and albuterol with respect to heart rate (Emax, ...
Tópico(s): Inhalation and Respiratory Drug Delivery
1996 - Elsevier BV | CHEST Journal
Lucie Blais, Philipp Ernst, Samy Suissa,
... found different risks for two inhaled β2-agonists, fenoterol and salbutamol. The authors assessed whether this companson was confounded indication because of channeling of inhaled fenoterol to more severely afflicted asthmatics. Using three subcohorts ... preferential prescribing of a first prescription of inhaled fenoterol, as opposed to inhaled salbutamol, and whether they ... likelihood of a switch from inhaled salbutamol to fenoterol as well as a switch from inhaled fenoterol to salbutarnol. The authors found that the initial ...
Tópico(s): Inhalation and Respiratory Drug Delivery
1996 - Oxford University Press | American Journal of Epidemiology
Michael T. Newhouse, Kenneth R. Chapman, Andrew L. McCallum, Raja T. Abboud, Dennis Bowie, Richard V. Hodder, Peter D. Paré, Hilda Mesic-Fuchs, Néstor A. Molfino,
Background It has been suggested that overuse of fenoterol metered-dose inhalers (MDIs) may increase the risk ... objective was to compare the cardiovascular safety of fenoterol and albuterol MDIs when administered in maximal bronchodilating ... spirometry), each patient received 4 puffs of either fenoterol, 200 µg per puff, or albuterol, 100 µg ... cumulative dose of 16 puffs of albuterol or fenoterol, side effects were intolerable to the patient, or ... dose. Results 128 patients were randomized to receive fenoterol and 129 to receive albuterol. Overall, fenoterol increased ...
Tópico(s): Pharmacological Effects and Assays
1996 - Elsevier BV | CHEST Journal
Produção Nacional
Revisado por pares
Carlos Alberto de Assis Viegas, Antoni Ferrer, Josep M. Montserrat, Joan Albert Barberà, Josep Roca, Robert Rodríguez-Roisin,
... gas exchange. Methods To assess the effects of fenoterol at both high and low dose on pulmonary ... exchange in 24 hypoxemic patients with stable COPD: fenoterol, 5 mg; fenoterol, 1 mg and ipratropium bromide, 0.5 mg; ... output (p=0.05) increased after high-dose fenoterol therapy to return to baseline values by 120 min. Following fenoterol at high dose, mean maximum PaO2 change from ... blood flow, without reaching significance; likewise, low-dose fenoterol therapy increased V ˙ A / Q ˙ inequalities while both ... In this population of COPD patients, high-dose fenoterol therapy did not significantly increase heart rate and ...
Tópico(s): Respiratory Support and Mechanisms
1996 - Elsevier BV | CHEST Journal
J.A. van Noord, Joseph J. Smeets, Jacques P.H.M. Creemers, Louis P.M. Greefhorst, Helen Dewberry, Piet J.G. Cornelissen,
... was carried out to determine the dose of fenoterol inhaled from Respimat<sup>®</sup> (RMT), a new ... 1 puff of either 100 or 200 µg fenoterol inhaled from a conventional CFC-MDI (Berotec<sup>®</ ... 12.5, 25, 50, 100, or 200 µg fenoterol via RMT, and 100 or 200 µg fenoterol delivered via the MDI. <i>Results:</i> Fifty- ... showed that the 12.5- and 25-µg fenoterol doses administered via RMT were equivalent to the 100 µg fenoterol dose from the MDI. The 50-, 100- and 200-µg fenoterol doses delivered by RMT did not meet the ...
Tópico(s): Advanced Chemical Sensor Technologies
2000 - Karger Publishers | Respiration
Christophe Faisy, Stanislas Grassin‐Delyle, Sabine Blouquit‐Laye, Marion Brollo, Emmanuel Naline, Alain Chapelier, Philippe Devillier,
... cultures of bronchial epithelial cells were incubated with fenoterol (0.1 µM, 15 hours, 37°C), a ... of inhibitors/blockers of Wnt signaling on the fenoterol-induced airway sensitization were examined and the impact of fenoterol exposure on the mRNA expression of genes interacting ... cultured epithelial cells. Results Compared to paired controls, fenoterol-sensitization was abolished by inhibition/blockage of the ... did not seem to be involved in the fenoterol-induced sensitization since the mRNA expression of Wnt ...
Tópico(s): Asthma and respiratory diseases
2014 - Public Library of Science | PLoS ONE
Brian J. Lipworth, D M Newnham, Robert A. Clark, D.P. Dhillon, J H Winter, DG McDevitt,
... is controversy as to the relative safety of fenoterol and salbutamol. No differences have been found in ... beta 1/beta 2 receptor activity of inhaled fenoterol and salbutamol in normal subjects. These initial findings ... respective potencies of equivalent doses by weight of fenoterol and salbutamol in asthmatic subjects, in terms of ... 97 (0.66)1) were randomised to inhale fenoterol (100 micrograms/puff or 200 micrograms/puff), salbutamol, ... increments. Dose ratios for the relative potency of fenoterol versus salbutamol were calculated from the dose-response ...
Tópico(s): Inhalation and Respiratory Drug Delivery
1995 - BMJ | Thorax
Yulia G. Odnoshivkina, Vaycheslav I. Sytchev, Л. Ф. Нуруллин, А. R. Giniatullin, А. Л. Зефиров, Alexey M. Petrov,
Fenoterol, a β2-adrenoceptor agonist, has anti-apoptotic action in cardiomyocytes and induces a specific pattern of ... signaling. We have previously reported that exposure to fenoterol (5 μM) results in a delayed positive inotropic ... oxygen species (ROS) production in response to the fenoterol administration and the involvement of ROS in effect ... intracellular ROS level rises only after removal of fenoterol from the bath. NADPH-oxidase inhibitor (apocynin) prevents ... cysteine, NADPH inhibitors, exogenous catalases) significantly inhibit the fenoterol induced increase in the contraction amplitude, probably by ...
Tópico(s): Cardiac electrophysiology and arrhythmias
2015 - Elsevier BV | European Journal of Pharmacology
Wei Wang, Yuan Zhang, Ming Xu, Youyi Zhang, Bei He,
... inflammation in several cell lines. We reported that fenoterol, a β2-adrenergic receptor (β2-AR) agonist, had ... 1 cells, a monocytic cell line. Whether the fenoterol anti-inflammatory effect involves the AMPK pathway is ... explored the mechanism of β2-AR stimulation with fenoterol in a lipopolysaccharide (LPS)-induced inflammatory cytokine secretion in THP-1 cells. We studied whether fenoterol and β-arrestin-2 or AMPKα1 subunit knockdown ... interleukin 1β (IL-1β) release were reduced with fenoterol pretreatment of THP-1 cells. SiRNA knockdown of ...
Tópico(s): Neuroinflammation and Neurodegeneration Mechanisms
2015 - Elsevier BV | Biochemical and Biophysical Research Communications