Catarina M. Ferreira, Ana Margarida Barbosa, Palmira Barreira‐Silva, Ricardo Silvestre, Cristina Cunha, Agostinho Carvalho, Fernando Rodrigues, Margarida Correia‐Neves, António G. Castro, Egídio Torrado,
Cytokine-producing CD4+ T cells play a crucial role in the control of Mycobacterium tuberculosis infection; however, there is a delayed appearance of effector T cells in the lungs following aerosol infection. The immunomodulatory cytokine IL-10 antagonizes control of M. tuberculosis infection through mechanisms associated with reduced CD4+ T cell responses. Here, we show that IL-10 overexpression only before the onset of the T cell response impaired control of M. tuberculosis growth; during chronic ...
Tópico(s): T-cell and B-cell Immunology
2021 - American Society for Clinical Investigation | JCI Insight
Carlos Capela, Ange Dodji Dossou, Rita Silva-Gomes, Ghislain Emmanuel Sopoh, Michel Makoutodé, João F. Menino, Alexandra G. Fraga, Cristina Cunha, Agostinho Carvalho, Fernando Rodrigues, Jorge Pedrosa,
Introduction Buruli ulcer (BU) is a severe necrotizing human skin disease caused by Mycobacterium ulcerans. Clinically, presentation is a sum of these diverse pathogenic hits subjected to critical immune-regulatory mechanisms. Among them, autophagy has been demonstrated as a cellular process of critical importance. Since microtubules and dynein are affected by mycolactone, the critical pathogenic exotoxin produced by M. ulcerans, cytoskeleton-related changes might potentially impair the autophagic ...
Tópico(s): Tuberculosis Research and Epidemiology
2016 - Public Library of Science | PLoS neglected tropical diseases
Grant S. Joseph, Colleen L. Seymour,
... John Carlson, Andrew Chin, Tobey Curtis, Luís Fernando Carvalho Costa, Luís Fernando Rodrigues Filho, Tommaso Giarrizzo, Jorge Luiz S. Nunes, João ...
Tópico(s): Rangeland Management and Livestock Ecology
2022 - Royal Society | Biology Letters
Nélson Oliveira, Pedro de la Rosa, Lavinia Borges, Emanuel Carvalho‐Dias, Fernando Rodrigues Oliveira, Isabel Cássio,
The aim of this study is to evaluate the role of hyperbaric oxygen in the treatment of diabetic foot ulcers.We performed a retrospective observational study of all patients with diabetic foot ulcers treated at the Institution's hyperbaric chamber between January 2010 and August 2012. Patient data was obtained upon patient hospital visit and prospective clinical record consultation.Twenty-six foot lesions including 13 foot ulcers Wagner grade 2 or greater and 13 amputation stump ulcers were submitted ...
Tópico(s): Pressure Ulcer Prevention and Management
2014 - Elsevier BV | Foot and Ankle Surgery
Produção Nacional
Revisado por pares
Sara Karla F. de Medeiros, Werther Brunow de Carvalho, Cláudio Fernando Rodrigues Soriano,
To investigate the use of nasal intermittent positive pressure ventilation (NIPPV) in level three neonatal intensive care units (NICU) in northeastern Brazil.This observational cross-sectional survey was conducted from March 2009 to January 2010 in all level three NICUs in northeastern Brazil that are registered in the Brazilian Registry of Health Establishments (Cadastro Nacional de Estabelecimentos de Saúde, CNES) of the Ministry of Health. Questionnaires about the use of NIPPV were sent to the NICU ...
Tópico(s): Respiratory Support and Mechanisms
2012 - Elsevier BV | Jornal de Pediatria
Produção Nacional
Revisado por pares
Enner Alcântara, José Roberto Mantovani, Luiz Rotta, Edward Park, Thanan Rodrigues, Fernando Carvalho, Carlos Roberto de Souza Filho,
As of 16 May 2020, the number of confirmed cases and deaths in Brazil due to COVID-19 hit 233,142 and 15,633, respectively, making the country one of the most affected by the pandemic. The State of São Paulo (SSP) hosts the largest number of confirmed cases in Brazil, with over 60,000 cases to date. Here we investigate the spatial distribution and spreading patterns of COVID-19 in the SSP by mapping the spatial autocorrelation and the clustering patterns of the virus in relation to the population ...
Tópico(s): Spatial and Panel Data Analysis
2020 - PAGEPress (Italy) | Geospatial health
Produção Nacional
Revisado por pares
Frederico Diniz Lima, Daniel Neis Stamm, Iuri Domingues Della-Pace, Fernando Dobrachinski, Nélson Rodrigues de Carvalho, Luiz Fernando Freire Royes, Félix Alexandre Antunes Soares, João Batista Teixeira da Rocha, Javier González‐Gallego, Guilherme Bresciani,
Background and Aims Although acute exhaustive exercise is known to increase liver reactive oxygen species (ROS) production and aerobic training has shown to improve the antioxidant status in the liver, little is known about mitochondria adaptations to aerobic training. The main objective of this study was to investigate the effects of the aerobic training on oxidative stress markers and antioxidant defense in liver mitochondria both after training and in response to three repeated exhaustive swimming ...
Tópico(s): Adipose Tissue and Metabolism
2013 - Public Library of Science | PLoS ONE
Produção Nacional
Revisado por pares
Geraldo Cardoso de Oliveira Neto, Luiz Eduardo Carvalho Chaves, Luiz Fernando Rodrigues Pinto, José Carlos Curvelo Santana, Marlene Amorim, Mário Rodrigues,
This study addressed the development of a pilot plant for pyrolysis of scrap tires to obtain carbon black and other byproducts. The work was motivated by the goal of contributing to the development and dissemination of knowledge about existing technologies that allow modern economies to transform waste into valuable products, by documenting and discussing an empirical application in Brazil. Thispaper describes the development of a market for steel scrap, pyrolytic oil and carbon black products obtained ...
Tópico(s): Graphite, nuclear technology, radiation studies
2019 - Multidisciplinary Digital Publishing Institute | Sustainability
Produção Nacional
Revisado por pares
Bruno Leite Rodrigues, Luís Fernando Carvalho-Costa, Israel de Souza Pinto, José Manuel Macário Rebêlo,
Sand fly (Diptera: Psychodidae) taxonomy is complex and time-consuming, which hampers epidemiological efforts directed toward controlling leishmaniasis in endemic regions such as northeastern Brazil. Here, we used a fragment of the mitochondrial cytochrome c oxidase I (COI) gene to identify sand fly species in Maranhão State (northeastern Brazil) and to assess cryptic diversity occurring at different spatial scales. For this, we obtained 148 COI sequences of 15 sand fly species (10 genera) from Maranhão ( ...
Tópico(s): Insect symbiosis and bacterial influences
2018 - Oxford University Press | Journal of Medical Entomology
Produção Nacional
Revisado por pares
Gustavo Orione Puntel, Nélson Rodrigues de Carvalho, Fernando Dobrachinski, Andréia Caroline Fernandes Salgueiro, Robson Luiz Puntel, Vanderlei Folmer, Nilda Vargas Barbosa, Luiz Fernando Freire Royes, João Batista Teixeira da Rocha, Félix Alexandre Antunes Soares,
Abstract The aim of this study was to analyze the effects of cryotherapy on the biochemical and morphological changes in ischemic and reperfused ( I / R ) gastrocnemius muscle of rats. Forty male W istar rats were divided into control and I / R groups, and divided based on whether or not the rats were submitted to cryotherapy. Following the reperfusion period, biochemical and morphological analyses were performed. Following cryotherapy, a reduction in thiobarbituric acid‐reactive substances and dichlorofluorescein ...
Tópico(s): Medical and Biological Ozone Research
2012 - Wiley | Journal of Anatomy
Produção Nacional
Revisado por pares
Michele Hinerasky da Silva, Edovando José Flores da Rosa, Nélson Rodrigues de Carvalho, Fernando Dobrachinski, João Batista Teixeira da Rocha, José L. Mauriz, Javier González‐Gallego, Félix Alexandre Antunes Soares,
Tópico(s): Selenium in Biological Systems
2011 - Springer Science+Business Media | Neurotoxicity Research
Produção Nacional
Revisado por pares
Rodrigo de Souza Balk, Jéssika Cristina Bridi, Rafael de Lima Portella, Nélson Rodrigues de Carvalho, Fernando Dobrachinski, Michele Hinerasky da Silva, Guilherme Pires Amaral, Glaecir Roseni Mundstock Dias, Nilda Vargas Barbosa, Félix Alexandre Antunes Soares,
Tópico(s): Tryptophan and brain disorders
2010 - Springer Science+Business Media | Neurochemical Research
Produção Nacional
Revisado por pares
Israel Molina, Milena Soriano Marcolino, Magda Carvalho Pires, Lucas Emanuel Ferreira Ramos, Rafael Tavares Silva, Milton Henriques Guimarães Júnior, Isaias José Ramos de Oliveira, Rafael Lima Rodrigues de Carvalho, Aline Gabrielle Sousa Nunes, A. L. F. de Barros, Ana Luiza Bahia Alves Scotton, Angélica Aparecida Coelho Madureira, Bárbara Lopes Farace, Cíntia Alcântara de Carvalho, Fernanda d’Athayde Rodrigues, Fernando Anschau, Fernando Antônio Botoni, Guilherme Fagundes Nascimento, Helena Duani, Henrique Cerqueira Guimarães, Joice Coutinho de Alvarenga, Leila Beltrami Moreira, Liege Barella Zandoná, Luana Fonseca de Almeida Messias, Luana Martins Oliveira, Luciane Kopittke, Luís César de Castro, Luísa Elem Almeida Santos, Máderson Alvares de Souza Cabral, Maria Angélica Pires Ferreira, Natália da Cunha Severino Sampaio, Neimy Ramos de Oliveira, Pedro Ledic Assaf, Sofia Jarjour Tavares Starling Lopes, Tatiani Oliveira Fereguetti, Veridiana Baldon dos Santos, Victor Eliel Bastos de Carvalho, Yuri Carlotto Ramires, Antônio Luiz Pinho Ribeiro, Freddy Antonio Brito Moscoso, Rogério de Moura, Carísi Anne Polanczyk, Maria Carmo Pereira Nunes,
Abstract Chagas disease (CD) continues to be a major public health burden in Latina America. Information on the interplay between COVID-19 and CD is lacking. Our aim was to assess clinical characteristics and in-hospital outcomes of patients with CD and COVID-19, and to compare it to non-CD patients. Consecutive patients with confirmed COVID-19 were included from March to September 2020. Genetic matching for sex, age, hypertension, diabetes mellitus and hospital was performed in a 4:1 ratio. Of the ...
Tópico(s): Parasites and Host Interactions
2021 - Nature Portfolio | Scientific Reports
Produção Nacional
Revisado por pares
Ariane V. S. Cebrian, Rafael dos Santos Carvalho, Arthur Rodrigues Jardim Barreto, Fernando E. Maturi, Hernane da Silva Barud, Róbson Rosa da Silva, Cristiano Legnani, M. Cremona, Sidney J. L. Ribeiro,
Abstract Bacterial cellulose (BC) is a biocompatible and nontoxic biopolymer that has been successfully used as a substrate for flexible organic light emitting diodes (OLEDs). Although BC membranes exhibit excellent mechanical properties and industrial scalability, they are semitransparent, which limits their performance. To improve the optical properties of BC membranes, methods such as the polymerization of different inorganic–organic hybrid materials and petrochemical derivative monomers have been ...
Tópico(s): Nanomaterials and Printing Technologies
2021 - Wiley | Advanced Sustainable Systems
Produção Nacional
Revisado por pares
Fernando Rodrigues de Carvalho, Rafael Queiroz Barros, Alyne Simões, Patrícia Moreira de Freitas,
Temporomandibular disorder (TMD) is the most common cause of orofacial and cervical skull pain and is considered to be a public health problem, affecting 5% to 12% of the world population. TMD is multifactorial and there are several types of treatment, with the conservative types being indicated more often as they are less aggressive and reversible. The main aim of these treatments is to relieve symptoms, reduce of pain, and restore orofacial and cervical skull functions. Photobiomodulation therapy ( ...
Tópico(s): Trigeminal Neuralgia and Treatments
2019 - Springer Science+Business Media | Trials
Produção Nacional
Fernando Rodrigues de Carvalho, Débora Aparecida Lentini-Oliveira, Lucila BF Prado, Gilmar Fernandes do Prado, Luciane Bizari Coin de Carvalho,
Background Apnoea is a breathing disorder marked by the absence of airflow at the nose or mouth. In children, risk factors include adenotonsillar hypertrophy, obesity, neuromuscular disorders and craniofacial anomalies. The most common treatment for obstructive sleep apnoea syndrome (OSAS) in childhood is adeno‐tonsillectomy. This approach is limited by its surgical risks, mostly in children with comorbidities and, in some patients, by recurrence that can be associated with craniofacial problems. ...
Tópico(s): Airway Management and Intubation Techniques
2016 - Elsevier BV | Cochrane library
Produção Nacional
Revisado por pares
Márcia Cristina da Silva Faria, Neife Aparecida Guinaim dos Santos, Maria Augusta Carvalho Rodrigues, Jairo Lisboa Rodrigues, Fernando Barbosa, Antônio C. Santos,
Both types of diabetes are associated with higher incidence of some types of cancer. Treating cancer in diabetic patients without aggravating diabetes-related complications is a challenge for clinicians. Additionally, little is known about how diabetes affects the treatment of cancer. One of the most effective chemotherapeutic drugs is cisplatin, which is nephrotoxic. Studies suggest that diabetes acts as a protective factor against the nephrotoxicity of cisplatin, but the mechanisms involved have ...
Tópico(s): Chronic Myeloid Leukemia Treatments
2015 - Elsevier BV | Chemico-Biological Interactions
Produção Nacional
Débora Aparecida Lentini-Oliveira, Fernando Rodrigues de Carvalho, Clarissa Garcia Rodrigues, Qingsong Ye, Rongdang Hu, Hideko Minami-Sugaya, Luciane Bizari Coin de Carvalho, Lucila BF Prado, Gilmar Fernandes do Prado,
Background Anterior open bite occurs when there is a lack of vertical overlap of the upper and lower incisors. The aetiology is multifactorial including: oral habits, unfavourable growth patterns, enlarged lymphatic tissue with mouth breathing. Several treatments have been proposed to correct this malocclusion, but interventions are not supported by strong scientific evidence. Objectives The aim of this systematic review was to evaluate orthodontic and orthopaedic treatments to correct anterior ...
Tópico(s): Cleft Lip and Palate Research
2014 - Elsevier BV | Cochrane library
Produção Nacional
Revisado por pares
Fernando Rodrigues de Carvalho, Débora Aparecida Lentini-Oliveira, Graziele Maria Missiano Carvalho, Lucila Bizari Fernandes do Prado, Gilmar Fernandes do Prado, Luciane Bizari Coin de Carvalho,
Sleep Disordered Breathing (SDB) is a highly prevalent condition associated with orofacial and dentofacial characteristics. The aim of this study was to verify the association of dental malocclusion, molar relationship, crossbite, open bite, overjet, overbite, and crowding with SDB in children aged 7–9 years. Participating schools were selected randomly from within the public elementary school system. In the first phase of the study, the parents of 1216 children aged between 7 and 9 years old completed ...
Tópico(s): Gastroesophageal reflux and treatments
2014 - Elsevier BV | International Journal of Pediatric Otorhinolaryngology
Produção Nacional
Revisado por pares
Fernando Rodrigues de Carvalho, Débora Aparecida Lentini-Oliveira, Marco Antônio Cardoso Machado, Humberto Saconato, Lucila BF Prado, Gilmar Fernandes do Prado,
Background Apnoea is a breathing disorder marked by the absence of airflow at the nose or mouth. In children, risk factors include adenotonsillar hypertrophy, obesity, neuromuscular disorders and craniofacial anomalies. The most common treatment for obstructive sleep apnoea syndrome (OSAS) in childhood is adenotonsillectomy. This approach is limited by its surgical risks, mostly in children with comorbidities and, in some patients, by recurrence that can be associated with craniofacial problems. ...
Tópico(s): Airway Management and Intubation Techniques
2007 - Cochrane | Cochrane database of systematic reviews
Produção Nacional
Revisado por pares
Débora Aparecida Lentini-Oliveira, Fernando Rodrigues de Carvalho, Qingsong Ye, Junjie Luo, Humberto Saconato, Marco Antônio Cardoso Machado, Lucila BF Prado, Gilmar Fernandes do Prado,
Background Anterior open bite occurs when there is a lack of vertical overlap of the upper and lower incisors. The aetiology is multifactorial including: oral habits, unfavourable growth patterns, enlarged lymphatic tissue with mouth breathing. Several treatments have been proposed to correct this malocclusion, but interventions are not supported by strong scientific evidence. Objectives The aim of this systematic review was to evaluate orthodontic and orthopaedic treatments to correct anterior ...
Tópico(s): Temporomandibular Joint Disorders
2007 - Cochrane | Cochrane database of systematic reviews
Produção Nacional
Revisado por pares
Bruno Alarcon Fernandes Previdello, Fernando Rodrigues de Carvalho, André Luiz Tessaro, Vagner Roberto de Souza, Noboru Hioka,
Tópico(s): Chemical and Physical Properties in Aqueous Solutions
2006 - Brazilian Chemical Society | Química Nova
Produção Nacional
Revisado por pares
Bruno Alarcon Fernandes Previdello, Fernando Rodrigues de Carvalho, André Luiz Tessaro, Vagner Roberto de Souza, Noboru Hioka,
COLLOIDAL SYSTEMS.An experiment is proposed that can be included in undergraduate courses of chemistry.The subject is the acidity of organic compounds, which are employed as pH indicators, particularly in acid-base titrations.The indicators used are methyl orange, bromophenol blue and bromocresol green in aqueous medium.The influence of colloidal systems on the equilibrium is evaluated by the pK a .The colloids employed are surfactants like sodium dodecyl sulfate, cetyl-trimethylammonium bromide ...
Tópico(s): Environmental Chemistry and Analysis
2006 - Brazilian Chemical Society | Química Nova
... 10.1017/9781108564113.004André Rodrigues de Souza, Rafael Carvalho da Silva, Nathan Rodrigues Batista, William Fernando Antonialli Júnior, Fábio Santos do Nascimento Lack of ...
Tópico(s): Insect and Pesticide Research
1986 - University of Chicago Press | The American Naturalist
Produção Nacional
Revisado por pares
Débora Hungaro Micheletti, João Gabriel da Silva Andrade, Carlos Eduardo Porto, Bruna Hungaro Micheletti Alves, Fernando Rodrigues de Carvalho, Otávio Akira Sakai, Vagner Roberto Batistela,
Adsorption is important for treating water and effluents containing disposed dyes, particularly due to their intense industrial use. Extensive research in literature has focused on how to remove yellow tartrazine (TAR). Therefore, this study aims to describe TAR adsorbents, including materials, their efficiency, and kinetic parameters. To achieve this, studies published between January 2012 and January 2023 were selected. Among the TAR adsorbents, noteworthy options are chitosan- and chitin-based ...
Tópico(s): Electrochemical Analysis and Applications
2023 - Elsevier BV | Bioresource Technology Reports
Inês Mesquita, Carolina Ferreira, Ana Margarida Barbosa, Catarina M. Ferreira, Diana Moreira, Agostinho Carvalho, Cristina Cunha, Fernando Rodrigues, Ricardo Jorge Dinis‐Oliveira, Jérôme Estaquier, António G. Castro, Egídio Torrado, Ricardo Silvestre,
Leishmaniasis is a vector-borne disease caused by protozoan parasites from the genus Leishmania. The most severe form of disease is visceral leishmaniasis (VL), which is fatal if left untreated. It has been demonstrated that interleukin (IL)-10, is associated with disease progression and susceptibility. In this work, we took advantage of a transgenic mouse model that expresses high levels of IL-10 upon zinc sulfate administration (pMT-10). We addressed the role of IL-10 during the initial stages of ...
Tópico(s): Leptospirosis research and findings
2018 - Elsevier BV | Cytokine
Joana Gaifem, Luís G. Gonçalves, Ricardo Jorge Dinis‐Oliveira, Cristina Cunha, Agostinho Carvalho, Egídio Torrado, Fernando Rodrigues, Margarida Saraiva, António G. Castro, Ricardo Silvestre,
Dietary nutrients have emerged as potential therapeutic adjuncts for inflammatory bowel disease (IBD) given their impact on intestinal homeostasis through the modulation of immune response, gut microbiota composition and epithelial barrier stability. Several nutrients have already been associated with a protective phenotype. Yet, there is a lack of knowledge toward the most promising ones as well as the most adequate phase of action. To unveil the most prominent therapy candidates we characterized ...
Tópico(s): Digestive system and related health
2018 - Frontiers Media | Frontiers in Physiology
Maria Manuel Azevedo, Agostinho Carvalho, Cláudia Pascoal, Fernando Rodrigues, Fernanda Cássio,
Aquatic hyphomycetes are fungi that play a key role in plant litter decomposition in streams. Even though these fungi occur in metal-polluted streams, the mechanisms underlying their tolerance to metals are poorly documented. We addressed the effects of Zn and Cu in Varicosporium elodeae and Heliscus submersus by examining metal adsorption to cell walls, plasma membrane integrity and production of reactive oxygen species at metal concentrations inhibiting biomass production in 50% or 80%. The activity ...
Tópico(s): Chromium effects and bioremediation
2007 - Elsevier BV | The Science of The Total Environment
Produção Nacional
Revisado por pares
L Carvalho, Thiago Poleto, Camila Carvalho Ramos, Fernando de Assis Rodrigues, Victor Diogho Heuer de Carvalho, Thyago Celso Cavalcante Nepomuceno,
Digital competence plays an important role in higher education. The literature highlights the adoption and use of digital competence for the development of educational services in Higher Education Institutions (HEIs), but it is still necessary to understand its influence on the innovative behavior of the public official. This study aims to investigate the influence of digital competence, based on the predictors’ infrastructure, integration, and digital management, on innovative work behaviors. The ...
Tópico(s): Knowledge Management in Higher Education
2023 - Multidisciplinary Digital Publishing Institute | Administrative Sciences
Produção Nacional
Revisado por pares
Brunno Felipe Ramos Caetano, Mariana Baptista Tablas, Natália Elias Ferreira Pereira, Nelci Antunes de Moura, Robson Francisco Carvalho, Maria Aparecida Marchesan Rodrigues, Luı́s Fernando Barbisan,
Capsaicin (8-Methyl-N-vanillyl-(trans)-6-nonenamide) is the major pungent ingredient found in chili peppers consumed worldwide. Most reports on capsaicin potential carcinogenicity have yielded inconsistent findings. Some studies have shown that capsaicin exerts anti-proliferative and pro-apoptotic effects on different cancer cell lines, while others have reported an association between capsaicin at high doses with mutagenicity and carcinogenicity. Thus, this study aimed at assessing the effects of ...
Tópico(s): Genomics, phytochemicals, and oxidative stress
2017 - Elsevier BV | Toxicology and Applied Pharmacology