Catarina Tomás, Emanuel Oliveira, Daniellen Cristina Ferreira Sousa, Matheus Uba Chupel, Guilherme Eustáquio Furtado, Clara Rocha, Ana Teixeira, Pedro Lopes Ferreira, C. Alves, Stefan Gisin, Elisabete Catarino, Nelma Carvalho, Tiago Coucelo, Luís Américo Silva Bonfim, Carina Silva, Débora Franco, Jesús Alcoba González, Maria Helena de Agrela Gonçalves Jardim, Rita Silva, Cristina Lavareda Baixinho, Ma Helena Presado, Ma Fátima Marques, Mário E. Cardoso, Marina Cunha, Joana Mendes, Ana Xavier, Ana Galhardo, Margarida Couto, João Frade, Carla Nunes, João R. Mesquita, María Säo José Nascimento, Guilherme Gonçalves, Conceição Castro, Alice Mártires, M. João Monteiro, Conceição Rainho, Francisco P. Caballero, Fátima M. Monago, José T. Guerrero, Rocio M. Monago, Africa P. Trigo, Milagros L. Gutierrez, Gemma M. Milanés, Mercedes G. Reina, Ana G. Villanueva, Ana S. Piñero, Isabel R. Aliseda, Francisco Buitrago Ramírez, Andrea Ribeiro, Ana Quelhas, Maria Conceição Manso, Francisco P. Caballero, José T. Guerrero, Fátima M. Monago, Rafael Brito Santos, Nuria R. Jimenez, Cristina G. Nuñez, Inmaculada Rodríguez Gómez, Ma Jose L. Fernandez, Laura A. Marquez, Ana L. Moreno, Ma Jesus Tena Huertas, Francisco Buitrago Ramírez, Daniel Seabra, Ma Céu Salvador, Luciene Muniz Braga, Pedro Parreira, Anabela Salgueiro‐Oliveira, Cristina Arreguy-Sena, Bibiana F. Oliveira, Ma Adriana Henriques, Joana Santos, Sara Lebre, Alda Marques, Clarinda Festas, Sandra Rodrigues, Andrea Ribeiro, José Lumini‐Oliveira, Ana Gabriela Figueiredo, Francisco J. Hernandez-Martinez, Liliana Campi, Ma Pino Quintana-Montesdeoca, Juan F. Jimenez-Diaz, Bienvenida C. Rodriguez-De-Vera, Alexandra Parente, Ma Augusta Mata, Ana Ma Pereira, Adília Fernandes, Manuel Brás, Ma Rosário Pinto, Pedro Parreira, Marta Lima Basto, Ana C. Rei, Lisete Mónico, Gilberta Sousa, Clementina Morna, Otília Freitas, Gregório Freitas, Ana Carolina Gomes Jardim, Rita P. Vasconcelos, Lina G. Horta, Roger dos Santos Rosa, Luís Fernando Kranz, Rita C. Nugem, Mariana Santiago Siqueira, Ronaldo Bordin, Rosiane Kniess, Josimari Telino de Lacerda, Joana Guedes, Idalina Machado, Sidalina Almeida, Adriano Zilhão, Hélder Alves, Óscar Ribeiro, Ana Paula Martins Amaral, Ana Maria Ribeiro dos Santos, Joana Monteiro, Ma Clara Rocha, Rui Cruz, Ana Paula Martins Amaral, Marina Lourenço, Ma Clara Rocha, Rui Cruz, Sandra Regina Masetto Antunes, Verónica Mendonça, Isabel Andrade, Nádia Osório, Ana Valado, Armando Caseiro, Antonio Padua y Gabriel, Anabela Correia Martins, Fernando Mendes, Lídia Cabral, Manuela Ferreira, Amadeu Gonçalves, Tatiana Durão D`Ávila Luz, Leonardo Gomes de Oliveira Luz, Raúl A. Martins, Alice Murteira Morgado, Maria da Luz Vale-Dias, Rui Porta-Nova, Tânia Cristina Malezan Fleig, Éboni Marília Reuter, Miriam Beatris Froemming, Sabrina Luciane Camara Guerreiro, Lisiane Lisbôa Carvalho, Daniel Guedelha, Pedro S. Coelho, A.T. Pereira, António Calha, Raúl Cordeiro, Ana Gonçalves, Ana Certo, Ana Cristina Araújo de Andrade Galvão, Ma Augusta Mata, Aline Welter, Elayne Crestani Pereira, Sandra Aparecida Ribeiro, Márcia Regina Kretzer, Juan-Fernando Jiménez-Díaz, Carla Jiménez-Rodríguez, Francisco-José Hernández-Martínez, Bienvenida-Del-Carmen Rodríguez-De-Vera, Alexandre Marques-Rodrigues, Patrícia Brazil Pereira Coelho, Tiago Bernardes, Alexandre de Araújo Pereira, Patrícia Sousa, João Ghizzo Filho, Nazaré Otília Nazário, Márcia Regina Kretzer, Odete Amaral, António Garrido, Nélio Veiga, Carla Nunes, Ana Rita Pedro, Carlos Pereira, António Almeia, Hélder Miguel Fernandes, Carlos Vasconcelos, Nélson Sousa, Víctor Machado Reis, M. João Monteiro, Romeu Mendes, Isabel Pinto, Tânia C. S. P. Pires, João Gama, Vera Preto, Norberto Silva, Carlos Pires Magalhães, Matilde Martins, Mafalda Duarte, Constança Paúl, Ignácio Martín, Arminda Pinheiro, Sandra Doria Xavier, J. Azevedo, E. Bento, C. Marques, M. Marques, A. Macedo, A.T. Pereira, José Pedro Almeida, António Almeida, Josiane Alves, Nélson Sousa, Francisco Saavedra, Romeu Mendes, Ana S. Maia, Michelle Teixeira Oliveira, Anderson Reis de Sousa, Paulo P. Ferreira, Luci S. Lopes, Eujcely C. Santiago, Sílvia Monteiro, Ângelo Jesus, Armanda Colaço, Antônio Ivo de Carvalho, Rita P. Silva, Agostinho Cruz, Ana Ferreira, Catarina Marques, João Paulo Figueiredo, Susana Paix�ão, Ana Ferreira, Carla Lopes, Fernando Moreira, João Paulo Figueiredo, Ana Ferreira, Diana Ribeiro, Fernando Moreira, João Paulo Figueiredo, Susana Paix�ão, Telma Fernandes, Diogo Amado, Jéssica Denise Vieira Leal, Marcelo Costa Velho Mendes de Azevedo, Sónia Ramalho, Catarina Mangas, Jaime Ribeiro, Rita Maria de Abreu Gonçalves, Amélia Fernandes Nunes, Ana Rita Tuna, Carlos Martins, Henriqueta D. Forte, Cláudia Costa, José António Tenedório, Paula Santana, José Augusto Andrade, Joana Pinto, C. Campofiorito, S. C. Nunes, Ana Sofia Carmo, A. Kaliniczenco, Bárbara Erllen da Silva Alves, Francisco Mendes, Carlos Jesus, Felipe Paiva Fonseca, Flávia de Sousa Gehrke, Carlos Albuquerque, Rita Batista, Madalena Cunha, António Dias, Olivério Ribeiro, Rosa Maria Grangeiro Martins, Teresa Madeira, Catarina Peixoto-Plácido, Nuno Rebelo dos Santos, Osvaldo Santos, Astrid Bergland, Asta Bye, Carla Lopes, Violeta Alarcão, Beatriz Goulão, Nuno Mendonça, Paulo Nicola, J. Gorjão Clara, João Gomes, Ana Querido, Catarina Tomás, Daniel Carvalho, Marina Cordeiro, Marlene Rosa, Alda Marques, Daniela Brandão, Óscar Ribeiro, Lia Araújo, Constança Paúl, Beatriz Minghelli, Sylvina Richaud, Ana Laura Mendes, Joana Marta‐Simões, Inês A. Trindade, Cláudia Ferreira, Teresa Carvalho,
S1 Health literacy and health education in adolescence Catarina Cardoso Tomás S2 The effect of a walking program on the quality of life and well-being of people with schizophrenia Emanuel Oliveira, D. Sousa, M. Uba-Chupel, G. Furtado, C. Rocha, A. Teixeira, P. Ferreira S3 Diagnosis and innovative treatments - the way to a better medical practice Celeste Alves S4 Simulation-based learning and how it is a high contribution Stefan Gisin S5 Formative research about acceptability, utilization and promotion ...
BioMed Central
Cláudio Gonçalves Couto, Fernando Luiz Abrucio,
O presente artigo analisa os anos FHC, mais detidamente o seu segundo mandato, do ponto de vista do impacto dos condicionantes políticos e institucionais sobre a agenda governamental. Para isso, inicialmente elaboramos um modelo teórico e, por meio deste, estudamos a relação dos atores e suas estratégias com os temas das reformas constitucionais e da política econômica. Ao final, procuramos avaliar o quanto o presidente Fernando Henrique conseguiu mudar o modelo de Estado e instaurar um novo projeto.
Tópico(s): Rural Development and Agriculture
2003 - UNIVERSIDADE DE SÃO PAULO | Tempo Social
Produção Nacional
Revisado por pares
Rui Pereira, Hugo Matalonga, Marco Couto, Fernando Castor, Bruno Cabral, Pedro Carvalho, Simão Melo de Sousa, João Paulo Fernandes,
Tópico(s): Caching and Content Delivery
2021 - Springer Science+Business Media | Empirical Software Engineering
Andréia Dias, Gonçalo Cordeiro, María Manuela Estevinho, Rui Veiga, Luís Fígueira, Marta Reina‐Couto, Fernando Magro,
Abstract Recently, the gut microbiome has become an important field of interest. Indeed, the microbiome has been associated to numerous drug interactions and it is thought to influence the efficacy of pharmacologic treatments. Although statins are widely prescribed medications, there remains considerable variability in its therapeutic response. In this context, we aimed to investigate how statins modulate the gut microbiome and, reversely, how can the microbiome influence the course of anti‐hypercholesterolemic ...
Tópico(s): Helicobacter pylori-related gastroenterology studies
2020 - Wiley | Pharmacology Research & Perspectives
Produção Nacional
Revisado por pares
Ana Luiza Lunardi Rocha, Luciana Costa Faria, Thais Cristine Moura Guimarães, Geane Moreira, Ana Lúcia Cândido, Cláudia Alves Couto, Fernando M. Reis,
Tópico(s): Ovarian function and disorders
2017 - Springer Science+Business Media | Journal of Endocrinological Investigation
Produção Nacional
Revisado por pares
Carolina Luísa Alves Barbieri, Márcia Thereza Couto, Fernando Mussa Abujamra Aith,
This study aimed to learn how middle-class parents in the city of São Paulo, Brazil, interpreted the country's prevailing vaccination requirements, based on their experiences with vaccinating, selectively vaccinating, or not vaccinating their children. A qualitative approach was used with in-depth interviews. The analytical process was guided by content analysis and the theoretical framework of the anthropology of the law and morality. For parents that vaccinated, Brazil's culture of immunization ...
Tópico(s): Food Security and Health in Diverse Populations
2017 - Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz | Cadernos de Saúde Pública
Hugo Algarvio, António Couto, Fernando Lopes, Ana Estanqueiro, João Santana,
This article uses an agent-based system to analyze the potential impacts of variable generation on wholesale electricity markets. Specifically, the article presents some important features of the agent-based system, introduces a method to forecast wind power, and describes a case study to analyze the impact of both wind forecast errors and high levels of wind generation on the outcomes of the day-ahead market. The case study involved two simulations: a base case, where the market closes at 12:00 ...
Tópico(s): Smart Grid Energy Management
2016 - Springer Nature | Advances in intelligent systems and computing
D Couto, Fernando Mota, Henriqueta Coimbra Silva, Carlos Augusto Fernandes de Oliveira,
Endometrial adenocarcinoma and adenomyosis are both common pathologic conditions that develop in the uterus. Adenocarcinoma arising from adenomyosis is rare but has been described, with similar alterations in the endometrium. Furthermore, there have been a few reports of adenocarcinoma developing in adenomyotic areas without endometrial involvement (1–11). We report a case of endometrial adenocarcinoma arising in a focus of adenomyosis localized in the outer half of the myometrium, with no involvement ...
Tópico(s): Uterine Myomas and Treatments
2004 - Informa | Acta Obstetricia Et Gynecologica Scandinavica
Produção Nacional
Revisado por pares
Tiago Gräf, Alexander A. Martínez, Gonzalo Bello, Simon Dellicour, Philippe Lemey, Vittoria Colizza, Mattia Mazzoli, Chiara Poletto, Vanessa Leiko Oikawa Cardoso, Alexandre Freitas da Silva, Elsa Baumeister, Josefina Campos, Andrea Pontoriero, Indira Martin, Kirvina Ferguson, Draven Johnson, Songee Beckles, Kasandra Forde, Aldo Sosa, Roberto I. Meléndez, Roxana Loayza, Cinthia Avila, E. Fernández, Carol Jessica Guzman Otazo, Marilda Mendonça Siqueira, Fernando Couto Motta, Katia Corrêa de Oliveira Santos, Adriano Abbud, Mirleide Cordeiro dos Santos, Jessylene de Almeida Ferreira, Rodrigo Fasce, Jorge Fernandes, Sergio Rangel, Marcela Mercado, Dioselina Peláez, Claudio Soto-Garita, Estela Cordero-Laurent, Francisco Duarte-Martínez, Hebleen Brenes, Isaac Miguel Sánchez, Yvonne Imbert, Alfredo Bruno, Domenica Joseth de Mora Coloma, Dalia Xochitl Sandoval López, Denis Gerson Jovel Alvarado, Deny Lisset Martínez Morán, Claudia Pacheco, Linda Mendoza, Joyce Whyte-Chin, Mustapha Abdul-Kadir, Jacques Boncy, Ito Journel, Mitzi Castro Paz, Sofía Carolina Alvarado, Soany Avilez, Michelle Brown, Caludia Elena Wong Arambula, José Ernesto Ramírez–González, Alexander A. Martínez, C.M. González, Brechla Moreno Arévalo, Danilo Franco, Sandra López‐Vergès, Juan Miguel Pascale, Cynthia Vázquez, Sandra González, Nancy Rojas, Carlos Padilla, Phyllis S Pinas, Navienda Asebeh, Christine V. F. Carrington, Nikita Sahadeo, Héctor Chiparelli, Natalia Goñi, Lieska Rodríguez, Pierina D’Angelo, Fernando Couto Motta, Paola Cristina Resende, Marilda Mendonça Siqueira, Leticia Franco, Lionel Gresh, Jean-Marc Gabastou, Angel Rodríguez, Andrea Vicari, Sylvain Aldighieri, Jairo Méndez‐Rico, Juliana Almeida Leite,
Abstract Latin America and Caribbean (LAC) regions were an important epicenter of the COVID-19 pandemic and SARS-CoV-2 evolution. Through the COVID-19 Genomic Surveillance Regional Network (COVIGEN), LAC countries produced an important number of genomic sequencing data that made possible an enhanced SARS-CoV-2 genomic surveillance capacity in the Americas, paving the way for characterization of emerging variants and helping to guide the public health response. In this study we analyzed approximately ...
Tópico(s): Virology and Viral Diseases
2024 - Nature Portfolio | Nature Communications
Produção Nacional
Revisado por pares
Lucélio Bernardes Couto, Fernando Morgan de Aguiar Corrêa, Irene Rosemir Pelá,
The localization of brain sites where bradykinin (BK) induces its antinociceptive effect in rats, was studied using as index the threshold for the jaw‐opening reflex elicited by the dental pulp electrical stimulation test (DPEST). The microinjection of BK into the lateral or fourth cerebral ventricles induced an antinociceptive effect, with Index of Antinociception (IA) of 0.51±0.03 and 0.68±0.05, respectively. However, microinjections of the peptide into the third ventricle induced a less marked antinociception ( ...
Tópico(s): Pain Mechanisms and Treatments
1998 - Wiley | British Journal of Pharmacology
Produção Nacional
Revisado por pares
Ighor Arantes, Felipe Gomes Naveca, Tiago Gräf, Fábio Miyajima, Helisson Faoro, Gabriel Luz Wallau, Edson Delatorre, Luciana Appolinario, Elisa Cavalcante Pereira, Tainá Moreira Martins Venas, Alice Sampaio Barreto da Rocha, Renata Serrano Lopes, Marilda Mendonça Siqueira, Gonzalo Bello, Paola Cristina Resende, Carlos Leonardo Araújo, Cleber Furtado Akesenen, Fernando Braga Stehling Dias, Igor Oliveira Duarte, Jamille Mendes Bezerra, Joaquim Cesar Sousa, Pedro Miguel Carneiro Jerônimo, Suzana Almeida Porto, Thaís de Oliveira Costa, Thais Ferreira de Oliveira, Ticiane Cavalcante de Souza, Veridiana Pessoa Miyajima, Acacia Lourenço Francisco Nasr, Ana Carolina De la Vechia, Rosana Aparecida Piler, Tatiane Motta Huggler, Cristiano Fernandes, Marcelo Ferreira da Costa Gomes, Adriano Abbud, Katia Oliveira Correa, Alexandre Freitas da Silva, Antônio Marinho da Silva Neto, Cássia Docena, Filipe Zimmer Dezordi, Gustavo Barbosa de Lima, Laís Ceschini Machado, Lílian Caroliny Amorim Silva, Marcelo Henrique Santos Paiva, Matheus Filgueira Bezerra, Raul Emídio de Lima, Andréia Akemi Suzukawa, Mauro de Medeiros Oliveira, Michelle Orane Schemberger, Beatriz Grinsztejn, Patrícia Brasil, Valdiléa G. Veloso, Felicidade Mota Pereira, Dalane Loudal Florentino Teixeira, Haline Barroso, Anderson Brandão Leite, Vinicius Lemes da Silva, André Felipe Leal Bernardes, Felipe Campos de Melo Iani, Irina Nastassja Riediger, Maria do Carmo Debur, Themis Rocha, Andreia Santos Costa, Lindomar dos Anjos Silva, Tirza Mattos, Ana Barjud Marques, Maximo Liana Perdigão Mello, Vânia Angélica Feitosa Viana, Rodrigo Ribeiro Rodrigues, Darcita Büerger Rovaris, Sandra Bianchini Fernandes, Lídio Gonçãlves Lima Neto, Valnete Andrade, Andréa Cony Cavalcanti, Richard Steiner Salvato Tatiana Schäffer Gregianini, Jucimária Dantas Galvão, Ágatha Costa, André de Lima Guerra Corado, Fernanda Nascimento, George Silva, Karina Pessoa, Luciana Fé Gonçalves, Maria Júlia Brandão, Matilde Mejía, Michele Silva de Jesus, Valdinete Alves do Nascimento, Victor Costa de Souza, Bruna Mendonça da Silva, Fernando Couto Motta, Jéssica de Macedo Carvalho, Larissa Macedo Pinto, Fernando Vinhal, Isabela de Lucena Heráclio Morgana de Freitas Caraciolo, Roberta Mendes Abreu Silva, Silvio Rodrigues de Almeida, Thayna Karoline Sousa Silva, Alessandro Álvares Magalhães, Érika Lopes Rocha Batista, Greice Madeleine Ikeda do Carmo, Janaína Sallas, Walquíria Aparecida Ferreira de Almeida, Márcio Henrique de Oliveira Garcia, Cecília Leite Costa, Eduardo Ruback dos Santos, João Felipe Bezerra,
The SARS-CoV-2 variant of concern (VOC) Delta was first detected in India in October 2020. The first imported cases of the Delta variant in Brazil were identified in April 2021 in the southern region, followed by more cases in different regions during the following months. By early September 2021, Delta was already the dominant variant in the southeastern (87%), southern (73%), and northeastern (52%) Brazilian regions. This study aimed to understand the spatiotemporal dissemination dynamics of Delta ...
Tópico(s): COVID-19 epidemiological studies
2022 - American Society for Microbiology | Microbiology Spectrum
Produção Nacional
Revisado por pares
Dilton Ribeiro Couto, Fernando Pocahy, Felipe Carvalho,
Este texto explora a forma como os memes podem constituir-se enquanto potentes estratégias contemporâneas de subversão e resistência às normas que regulam/governam corpos, gêneros e sexualidades. A infraestrutura técnica do ciberespaço possibilita que uma quantidade significativa de usuárias/os hoje possa (co)criar, “curtir” e compartilhar amplamente informações dos mais variados tipos (imagens, vídeos, sons etc) para outras pessoas geograficamente dispersas. Muitas dessas informações desenvolvidas ...
Tópico(s): Social Media and Politics
2019 - UNIVERSIDADE DO ESTADO DO RIO DE JANEIRO | Periferia
De‐Hua Lai, Estefanía Poropat, Carlos Pravia, Malena Landoni, Alicia S. Couto, Fernando Perez Rojo, Alicia Graciela Fuchs, Marta Dubin, Igal Elingold, Juan B. Rodríguez, Marcela Ferella, Mónica I. Esteva, Esteban J. Bontempi, Julius Lukeš,
Ubiquinone 9 (UQ9), the expected product of the long-chain solanesyl diphosphate synthase of Trypanosoma brucei (TbSPPS), has a central role in reoxidation of reducing equivalents in the mitochondrion of T. brucei. The ablation of TbSPPS gene expression by RNA interference increased the generation of reactive oxygen species and reduced cell growth and oxygen consumption. The addition of glycerol to the culture medium exacerbated the phenotype by blocking its endogenous generation and excretion. The ...
Tópico(s): Coenzyme Q10 studies and effects
2013 - American Society for Microbiology | Eukaryotic Cell
Hugo Prazeres, Joana Couto, Fernando Rodrigues, João Vinagre, Joana Torres, Vítor Trovisco, Teresa Martins, Manuel Sobrinho‐Simões, Paula Soares,
Multiple endocrine neoplasia type 2 and a subset of apparently sporadic medullary thyroid carcinoma (AS-MTC) are caused by germ line activating point mutations of the rearranged during transfection ( RET ) proto-oncogene. RET encodes a receptor with tyrosine kinase activity that targets several intracellular signaling cascades, such as RAS–RAF–ERK1/2, PIK3–AKT, and STAT transcription factors. The objective of this study was to assess the function of three germ line RET variants Arg886Trp, Ser649Leu, ...
Tópico(s): Wnt/β-catenin signaling in development and cancer
2011 - Bioscientifica | Endocrine Related Cancer
Produção Nacional
Revisado por pares
Tiago Gräf, Gonzalo Bello, Felipe Gomes Naveca, Marcelo Ferreira da Costa Gomes, Vanessa Leiko Oikawa Cardoso, Alexandre Freitas da Silva, Filipe Zimmer Dezordi, Mirleide Cordeiro dos Santos, Mauro de Medeiros Oliveira, Érika Lopes Rocha Batista, Alessandro Leonardo Álvares Magalhães, Fernando Vinhal, Fábio Miyajima, Helisson Faoro, Ricardo Khouri, Gabriel Luz Wallau, Edson Delatorre, Marilda Mendonça Siqueira, Paola Cristina Resende, Tirza Mattos, Valdinete Alves do Nascimento, Victor Costa de Souza, André de Lima Guerra Corado, Fernanda Nascimento, George Silva, Matilde Mejía, Maria Júlia Brandão, Ágatha Costa, Karina Pessoa, Michele Silva de Jesus, Luciana Fé Gonçalves, Cristiano Fernandes, Valnete Andrade, Luana Soares Barbagelata, Ana Cecília Ribeiro Cruz, Andréa Ferreira da Costa, Lindomar dos Anjos Silva, Jucimária Dantas Galvão, Anderson Brandão Leite, Felicidade Mota Pereira, Thaís De Oliveira Costa, Joaquim Cesar Sousa, Lídio Gonçãlves Lima Neto, Haline Barroso, Dalane Loudal Florentino Teixeira, João Felipe Bezerra, Cássia Docena, Raul Emídio de Lima, Lílian Caroliny Amorim Silva, Gustavo Barbosa de Lima, Laís Ceschini Machado, Matheus Filgueira Bezerra, Marcelo Henrique Santos Paiva, Maria Eduarda Pessoa Lopes Dantas, Raíssa Liane Do Nascimento Pereira, Josélio Maria Galvão de Araújo, Cliomar A. Santos, Rodrigo Ribeiro‐Rodrigues, André Felipe Leal Bernardes, Felipe Campos de Melo Iani, Beatriz Grinsztejn, Valdiléa G. Veloso, Patrícia Brasil, Anna Carolina Dias Paixão, Luciana Appolinario, Renata Serrano Lopes, Fernando Couto Motta, Alice Sampaio Barreto da Rocha, Tainá Moreira Martins Venas, Elisa Cavalcante Pereira, Andréa Cony Cavalcanti, Leonardo da Costa Bastos, Luís Fernando de Macedo Brígido, Mauro de Medeiros Oliveira, Michelle Orane Schemberger, Andréia Akemi Suzukawa, Irina Nastassja Riediger, Maria do Carmo Debur, Richard Steiner Salvato, Tatiana Schäffer Gregianini, Darcita Büerger Rovaris, Sandra Bianchini Fernandes,
The COVID-19 epidemic in Brazil experienced two major lineage replacements until mid-2021. The first was driven by lineage P.2, in late 2020, and the second by lineage Gamma, in early 2021. To understand how these SARS-CoV-2 lineages spread in Brazil, we analyzed 11,724 genomes collected throughout the country between September 2020 and April 2021. Our findings indicate that lineage P.2 probably emerged in July 2020 in the Rio de Janeiro state and Gamma in November 2020 in the Amazonas state. Both ...
Tópico(s): vaccines and immunoinformatics approaches
2022 - Cell Press | iScience
Produção Nacional
Revisado por pares
Anderson F. Brito, Elizaveta Semenova, Gytis Dudas, Gabriel W. Hassler, Chaney C. Kalinich, Moritz U. G. Kraemer, Joses Ho, Houriiyah Tegally, George Githinji, Charles N. Agoti, Lucy Matkin, Charles Whittaker, Todor Kantardjiev, Nelly Korsun, Savina Stoitsova, Reneta Dimitrova, Ivelina Trifonova, Veselin Dobrinov, Lubomira Grigorova, Ivan Stoykov, Iliana Grigorova, Anna Gancheva, Amy V. Jennison, Lex E.X. Leong, David Speers, Robert Baird, Louise Cooley, Karina Kennedy, Joep de Ligt, William D. Rawlinson, Sebastiaan J. van Hal, Deborah A. Williamson, Risha Singh, Sue-Min Nathaniel-Girdharrie, Lisa Edghill, Lisa Indar, Joy St. John, Gabriel González-Escobar, Vernie Ramkisoon, Arianne Brown Jordan, Anushka Ramjag, Nicholas Mohammed, J. E. Foster, Irad Potter, Sharra Greenaway-Duberry, Kenneth George, Sharon Belmar-George, J. Jack Lee, Jacqueline Bisasor-McKenzie, Nadia Astwood, Rhonda Sealey-Thomas, Hazel Laws, Narine Singh, Ayoola Oyinloye, Pearl McMillan, Avery Hinds, Naresh Nandram, Roshan Parasram, Zobida Khan-Mohammed, Shawn Charles, Aisha Andrewin, D. Barrie Johnson, Simone Keizer-Beache, Chris Oura, Oliver G. Pybus, Nuno R. Faria, Marc Stegger, Mads Albertsen, Anders Fomsgaard, Morten Rasmussen, Ricardo Khouri, Felipe Gomes Naveca, Tiago Gräf, Fábio Miyajima, Gabriel Luz Wallau, Fernando Couto Motta, Shruti Khare, Lucas Freitas, Constanza Schiavina, Gunter Bach, Mark B. Schultz, Yi Hong Chew, Meera Makheja, Priscila Born, Gabriela Calegário, Sofia Romano, Juan Finello, Amadou Diallo, Raphael Tze Chuen Lee, Ya Ni Xu, Winston Yeo, Suma Tiruvayipati, Shilpa Yadahalli, Eduan Wilkinson, Arash Iranzadeh, Jennifer Giandhari, Deelan Doolabh, Sureshnee Pillay, Upasana Ramphal, James Emmanuel San, Nokukhanya Msomi, Koleka Mlisana, Anne von Gottberg, Sibongile Walaza, Arshad Ismail, Thabo Mohale, Susan Engelbrecht, Gert U. van Zyl, Wolfgang Preiser, Alex Sigal, Diana Hardie, Gert Marais, Marvin Hsiao, Stephen N.J. Korsman, Mary‐Ann Davies, Lynn Tyers, Innocent Mudau, Denis York, Caroline Maslo, Dominique Goedhals, Shareef Abrahams, Oluwakemi Laguda-Akingba, Arghavan Alisoltani, Adam Godzik, Constantinos Kurt Wibmer, Darren P. Martin, Richard Lessells, Jinal N. Bhiman, Carolyn Williamson, Túlio de Oliveira, Chaoran Chen, Sarah Nadeau, Louis du Plessis, Christiane Beckmann, Maurice Redondo, Olivier Kobel, Christoph Noppen, Sophie Seidel, Noemie Santamaria de Souza, Niko Beerenwinkel, Ivan Topolsky, Philipp Jablonski, Lara Fuhrmann, David Dreifuss, Katharina Jahn, Pedro Ferreira, Susana Posada-Céspedes, Christian Beisel, Rebecca Denes, Mirjam Feldkamp, Ina Nissen, Natascha Santacroce, Elodie Burcklen, Catharine Aquino, Andreia Cabral de Gouvea, Maria Moccia, Simon Grüter, Timothy Sykes, Lennart Opitz, Griffin White, Laura Neff, Doris Popovic, Andrea Patrignani, Jay Tracy, Ralph Schlapbach, Emmanouil T. Dermitzakis, Keith Harshman, Ioannis Xénarios, Henri Pegeot, Lorenzo Cerutti, Deborah Penet, Tanja Stadler, Benjamin P. Howden, Vitali Sintchenko, Neta S. Zuckerman, Orna Mor, Heather M. Blankenship, Túlio de Oliveira, Raymond Tzer Pin Lin, Marilda Mendonça Siqueira, Paola Cristina Resende, Ana Tereza Ribeiro de Vasconcelos, Fernando Rosado Spilki, Renato Santana Aguiar, Ivailo Alexiev, Ivan Ivanov, Ivva Philipova, Christine V. F. Carrington, Nikita Sahadeo, Ben Branda, Céline Gurry, Sebastian Maurer‐Stroh, Dhamari Naidoo, Karin J. von Eije, Mark D. Perkins, Maria D. Van Kerkhove, Sarah C. Hill, Éster Cerdeira Sabino, Oliver G. Pybus, Christopher Dye, Samir Bhatt, Seth Flaxman, Marc A. Suchard, Nathan D. Grubaugh, Guy Baele, Nuno R. Faria,
Abstract Genomic sequencing is essential to track the evolution and spread of SARS-CoV-2, optimize molecular tests, treatments, vaccines, and guide public health responses. To investigate the global SARS-CoV-2 genomic surveillance, we used sequences shared via GISAID to estimate the impact of sequencing intensity and turnaround times on variant detection in 189 countries. In the first two years of the pandemic, 78% of high-income countries sequenced >0.5% of their COVID-19 cases, while 42% of low- ...
Tópico(s): SARS-CoV-2 detection and testing
2022 - Nature Portfolio | Nature Communications
Produção Nacional
Revisado por pares
Juliana Almeida Leite, Andrea Vicari, Enrique Pérez Gutiérrez, Marilda Mendonça Siqueira, Paola Cristina Resende, Fernando Couto Motta, Lucas Freitas, Jorge Onrubia Fernández, Bárbara Parra, Andrés Castillo, Rodrigo Fasce, Alexander A. Martínez, Lionel Gresh, Sylvain Aldighieri, Jean-Marc Gabastou, Leticia Franco, Jairo Méndez‐Rico,
The timely release of SARS-CoV-2 first genomic sequences allowed the identification of the etiologic agent and development of diagnostic protocols. Genomic sequencing was a crucial step in generating data for driving laboratory response and detections of SARS-CoV-2 since the start of the COVID-19 pandemic. Because of all the progression and achievements that timely release of genetic sequence data represents in the public health response, the Pan American Health Organization (PAHO) in collaboration ...
Tópico(s): Viral gastroenteritis research and epidemiology
2022 - Public Library of Science | PLoS ONE
Produção Nacional
Revisado por pares
Débora Ferreira Barreto-Vieira, Marcos Alexandre Nunes da Silva, Ana Luisa Teixeira de Almeida, Arthur da Costa Rasinhas, M. Monteiro, Milene Dias Miranda, Fernando Couto Motta, Marilda Mendonça Siqueira, Wendell Girard‐Dias, Bráulio S. Archanjo, Patrı́cia T. Bozza, Thiago Moreno L. Souza, Suelen da Silva Gomes Dias, Vinícius Cardoso Soares, Ortrud Monika Barth,
The pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has impacted public health and the world economy and fueled a worldwide race to approve therapeutic and prophylactic agents, but so far there are no specific antiviral drugs. Understanding the biology of the virus is the first step in structuring strategies to combat it, and in this context several studies have been conducted with the aim of understanding the replication mechanism of SARS-CoV-2 in vitro systems. ...
Tópico(s): COVID-19 Clinical Research Studies
2022 - Multidisciplinary Digital Publishing Institute | Viruses
Produção Nacional
Revisado por pares
Daiana Mir, Natalia Rego, Paola Cristina Resende, Fernando López Tort, Tamara Fernandez‐Calero, Verónica Noya, Mariana Brandes, Tania Possi, Mailén Arleo, Natalia Reyes, Matías Victoria, Andrés Lizasoain, Matías Castells, Leticia Maya, Matías Salvo, Tatiana Schäffer Gregianini, Marilda Tereza Mar da Rosa, Letícia Garay Martins, Cecilia Alonso, Yasser Vega, Cecilia Salazar, Ignacio Ferrés, Pablo Smircich, José Sotelo‐Silveira, Rafael Sebastián Fort, Cecilia Mathó, Ighor Arantes, Luciana Appolinario, Ana Carolina da Fonseca Mendonça, María José Benítez-Galeano, Camila Simoes, Martín Graña, Fernando Couto Motta, Marilda Mendonça Siqueira, Gonzalo Bello, Rodney Colina, Lucía Spangenberg,
Uruguay is one of the few countries in the Americas that successfully contained the coronavirus disease 19 (COVID-19) epidemic during the first half of 2020. Nevertheless, the intensive human mobility across the dry border with Brazil is a major challenge for public health authorities. We aimed to investigate the origin of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains detected in Uruguayan localities bordering Brazil as well as to measure the viral flux across this ∼1,100 km ...
Tópico(s): SARS-CoV-2 detection and testing
2021 - Frontiers Media | Frontiers in Microbiology
Produção Nacional
Revisado por pares
Paola Cristina Resende, Edson Delatorre, Tiago Gräf, Daiana Mir, Fernando Couto Motta, Luciana Appolinario, Anna Carolina Dias Paixão, Ana Carolina da Fonseca Mendonça, Maria Ogrzewalska, Bráulia Costa Caetano, Gabriel Luz Wallau, Cássia Docena, Mirleide Cordeiro dos Santos, Jessylene de Almeida Ferreira, Edivaldo Costa Sousa, Sandro Patroca da Silva, Sandra Bianchini Fernandes, Lucas A. Vianna, Larissa da Costa Souza, Jean F G Ferro, Vanessa Brandão Nardy, Cliomar A. Santos, Irina Nastassja Riediger, Maria do Carmo Debur, Júlio Croda, Wanderson Kleber de Oliveira, André Luiz de Abreu, Gonzalo Bello, Marilda Mendonça Siqueira,
A previous study demonstrates that most of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) Brazilian strains fell in three local clades that were introduced from Europe around late February 2020. Here we investigated in more detail the origin of the major and most widely disseminated SARS-CoV-2 Brazilian lineage B.1.1.33. We recovered 190 whole viral genomes collected from 13 Brazilian states from February 29 to April 31, 2020 and combined them with other B.1.1 genomes collected globally. ...
Tópico(s): Viral Infections and Outbreaks Research
2021 - Frontiers Media | Frontiers in Microbiology
Produção Nacional
Revisado por pares
Débora Ferreira Barreto-Vieira, Marcos Alexandre Nunes da Silva, Cristiana C. Garcia, Milene Dias Miranda, Aline da Rocha Matos, Bráulia Costa Caetano, Paola Cristina Resende, Fernando Couto Motta, Marilda Mendonça Siqueira, Wendell Girard‐Dias, Bráulio S. Archanjo, Ortrud Monika Barth,
The coronaviruses (CoVs) called the attention of the world for causing outbreaks of severe acute respiratory syndrome (SARS-CoV), in Asia in 2002-03, and respiratory disease in the Middle East (MERS-CoV), in 2012. In December 2019, yet again a new coronavirus (SARS-CoV-2) first identified in Wuhan, China, was associated with a severe respiratory infection, known today as COVID-19. This new virus quickly spread throughout China and 30 additional countries. As result, the World Health Organization (WHO) ...
Tópico(s): COVID-19 epidemiological studies
2021 - Instituto Oswaldo Cruz, Ministério da Saúde | Memórias do Instituto Oswaldo Cruz
Produção Nacional
Revisado por pares
Tatiana Prado, Túlio Machado Fumian, Camille Ferreira Mannarino, Paola Cristina Resende, Fernando Couto Motta, Ana Lúcia Fontes Eppinghaus, Vitor Hugo Chagas do Vale, Ricardo Marinho Soares Braz, Juliana da Silva Ribeiro de Andrade, Adriana Gonçalves Maranhão, Marize Pereira Miagostovich,
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) wastewater-based epidemiology (WBE) has been applied as a complementary approach for spatial tracking of coronavirus disease 2019 cases (COVID-19) as well as early warning of the occurrence of infected populations. The present study presents the result of the monitoring of sanitary sewerage in the municipality of Niterói, a metropolitan region of Rio de Janeiro (Brazil) and its use as a complementary indicator in the surveillance of COVID- ...
Tópico(s): Biosensors and Analytical Detection
2021 - Elsevier BV | Water Research
Produção Nacional
Revisado por pares
Guilherme Amaral Calvet, Sandro Antônio Pereira, Maria Ogrzewalska, Alex Pauvolid‐Corrêa, Paola Cristina Resende, Wagner de Souza Tassinari, Anielle de Pina Costa, Lucas Keidel, Alice Sampaio Barreto da Rocha, Michele Fernanda Borges da Silva, Shanna Araujo dos Santos, Ana Beatriz Machado Lima, Isabella C. V. Moraes, Artur Augusto Velho Mendes, Thiago das Chagas Souza, Ezequias Batista Martins, Renato Orsini Ornellas, Maria Lopes Corrêa, Isabela Maria da Silva Antonio, Lusiele Guaraldo, Fernando Couto Motta, Patrícia Brasil, Marilda Mendonça Siqueira, Isabella Dib Ferreira Gremião, Rodrigo Caldas Menezes,
Infection by SARS-CoV-2 in domestic animals has been related to close contact with humans diagnosed with COVID-19. Objectives: To assess the exposure, infection, and persistence by SARS-CoV-2 of dogs and cats living in the same households of humans that tested positive for SARS-CoV-2, and to investigate clinical and laboratory alterations associated with animal infection.Animals living with COVID-19 patients were longitudinally followed and had nasopharyngeal/oropharyngeal and rectal swabs collected ...
Tópico(s): Animal Virus Infections Studies
2021 - Public Library of Science | PLoS ONE
Produção Nacional
Revisado por pares
Paola Cristina Resende, João Felipe Bezerra, Romero Henrique Teixeira Vasconcelos, Ighor Arantes, Luciana Appolinario, Ana Carolina da Fonseca Mendonça, Anna Carolina Dias Paixão, Ana Carolina Duarte, Thauane Silva, Alice Sampaio Barreto da Rocha, Ana Beatriz Machado Lima, Alex Pauvolid‐Corrêa, Fernando Couto Motta, Dalane Loudal Florentino Teixeira, Thiago Franco de Oliveira Carneiro, Francisco Paulo Freire Neto, Isabel Diniz Herbster, Anderson Brandão Leite, Irina Nastassja Riediger, Maria do Carmo Debur, Felipe Gomes Naveca, Walquíria Aparecida Ferreira de Almeida, Mirian Livorati, Gonzalo Bello, Marilda Mendonça Siqueira,
A 37-year-old healthcare worker from the northeastern region of Brazil experienced 2 clinical episodes of coronavirus disease. Infection with severe acute respiratory syndrome coronavirus 2 was confirmed by reverse transcription PCR in samples collected 116 days apart. Whole-genome sequencing revealed that the 2 infections were caused by the most prevalent lineage in Brazil, B.1.1.33, and the emerging lineage P.2. The first infection occurred in June 2020; Bayesian analysis suggests reinfection ...
Tópico(s): SARS-CoV-2 detection and testing
2021 - Centers for Disease Control and Prevention | Emerging infectious diseases
Produção Nacional
Revisado por pares
Paola Cristina Resende, Tiago Gräf, Anna Carolina Dias Paixão, Luciana Appolinario, Renata Serrano Lopes, Ana Carolina da Fonseca Mendonça, Alice Sampaio Barreto da Rocha, Fernando Couto Motta, Lídio Gonçãlves Lima Neto, Ricardo Khouri, Camila I. de Oliveira, Pedro Santos‐Muccillo, João Felipe Bezerra, Dalane Loudal Florentino Teixeira, Irina Nastassja Riediger, Maria do Carmo Debur, Rodrigo Ribeiro‐Rodrigues, Anderson Brandão Leite, Cliomar A. Santos, Tatiana Schäffer Gregianini, Sandra Bianchini Fernandes, André Felipe Leal Bernardes, Andréa Cony Cavalcanti, Fábio Miyajima, Claudio Sachhi, Tirza Mattos, Cristiano Fernandes da Costa, Edson Delatorre, Gabriel Luz Wallau, Felipe Gomes Naveca, Gonzalo Bello, Marilda Mendonça Siqueira,
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic in Brazil was dominated by two lineages designated as B.1.1.28 and B.1.1.33. The two SARS-CoV-2 variants harboring mutations at the receptor-binding domain of the Spike (S) protein, designated as lineages P.1 and P.2, evolved from lineage B.1.1.28 and are rapidly spreading in Brazil. Lineage P.1 is considered a Variant of Concern (VOC) because of the presence of multiple mutations in the S protein (including K417T, E484K, N501Y), ...
Tópico(s): Plant Virus Research Studies
2021 - Multidisciplinary Digital Publishing Institute | Viruses
Produção Nacional
Revisado por pares
Tiago Gräf, Gonzalo Bello, Tainá Moreira Martins Venas, Elisa Cavalcante Pereira, Anna Carolina Dias Paixão, Luciana Appolinario, Renata Serrano Lopes, Ana Carolina da Fonseca Mendonça, Alice Sampaio Barreto da Rocha, Fernando Couto Motta, Tatiana Schäffer Gregianini, Richard Steiner Salvato, Sandra Bianchini Fernandes, Darcita Büerger Rovaris, Andréa Cony Cavalcanti, Anderson Brandão Leite, Irina Nastassja Riediger, Maria do Carmo Debur, André Felipe Leal Bernardes, Rodrigo Ribeiro‐Rodrigues, Beatriz Grinsztejn, Valdinete Alves do Nascimento, Victor Costa de Souza, Luciana Gonçalves, Cristiano Fernandes da Costa, Tirza Mattos, Filipe Zimmer Dezordi, Gabriel Luz Wallau, Felipe Gomes Naveca, Edson Delatorre, Marilda Mendonça Siqueira, Paola Cristina Resende,
Abstract One of the most remarkable severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOC) features is the significant number of mutations they acquired. However, the specific factors that drove the emergence of such variants since the second half of 2020 are not fully resolved. In this study, we describe a new SARS-CoV-2 P.1 sub-lineage circulating in Brazil, denoted here as Gamma-like-II, that as well as the previously described lineage Gamma-like-I shares several ...
Tópico(s): Viral Infections and Outbreaks Research
2021 - University of Oxford | Virus Evolution
Produção Nacional
Revisado por pares
Paola Cristina Resende, Felipe Gomes Naveca, Roberto D. Lins, Filipe Zimmer Dezordi, Matheus Ferraz, Emerson G. Moreira, Danilo F. Côelho, Fernando Couto Motta, Anna Carolina Dias Paixão, Luciana Appolinario, Renata Serrano Lopes, Ana Carolina da Fonseca Mendonça, Alice Sampaio Barreto da Rocha, Valdinete Alves do Nascimento, Victor Costa de Souza, George Silva, Fernanda Nascimento, Lídio Gonçãlves Lima Neto, Fabiano Vieira da Silva, Irina Nastassja Riediger, Maria do Carmo Debur, Anderson Brandão Leite, Tirza Mattos, Cristiano Fernandes da Costa, Felicidade Mota Pereira, Cliomar Alves dos Santos, Darcita Büerger Rovaris, Sandra Bianchini Fernandes, Adriano Abbud, Cláudio Tavares Sacchi, Ricardo Khouri, André Felipe Leal Bernardes, Edson Delatorre, Tiago Gräf, Marilda Mendonça Siqueira, Gonzalo Bello, Gabriel Luz Wallau,
Mutations at both the receptor-binding domain (RBD) and the amino (N)-terminal domain (NTD) of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike (S) glycoprotein can alter its antigenicity and promote immune escape. We identified that SARS-CoV-2 lineages circulating in Brazil with mutations of concern in the RBD independently acquired convergent deletions and insertions in the NTD of the S protein, which altered the NTD antigenic-supersite and other predicted epitopes at this region. ...
Tópico(s): SARS-CoV-2 detection and testing
2021 - University of Oxford | Virus Evolution
Tamara Camino, Nerea Lago‐Baameiro, Susana B. Bravo, Aurelio M. Sueiro, Ivan Couto‐González, Fernando Santos, Javier Baltar, Felipe F. Casanueva, María Pardo,
Extracellular vesicles (EVs) have recently emerged as a relevant way of cell to cell communication, and its analysis has become an indirect approach to assess the cell/tissue of origin status. However, the knowledge about their nature and role on metabolic diseases is still very scarce. We have established an insulin resistant (IR) and two lipid (palmitic/oleic) hypertrophied adipocyte cell models to isolate EVs to perform a protein cargo qualitative and quantitative Sequential Window Acquisition of ...
Tópico(s): MicroRNA in disease regulation
2020 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Produção Nacional
Revisado por pares
Daniel Althoff, Robson Argolo dos Santos, Helizani Couto Bazame, Fernando França da Cunha, Roberto Filgueiras,
Improving irrigation water management is an important asset when facing increased water shortages. The Hargreaves–Samani (HS) method is a simple method that can be used as an alternative to the Penman–Monteith (PM) method, which requires only temperature measurements for estimating reference evapotranspiration (ETo). However, the applicability of this method relies on its calibration to local meteorological specificities. The objective of this study was to investigate the effects of local calibration ...
Tópico(s): Irrigation Practices and Water Management
2019 - Multidisciplinary Digital Publishing Institute | Water
Produção Nacional
Marcelo Picolotto Corso, Stéfano Frizzo Stefenon, Vitor Fernando Couto, S. H. L. Cabral, Ademir Nied,
This paper has the purpose of evaluating the application of computer simulation methods for characterizing the distribution of the electric field generated by power transmission lines. Analysis through computer simulation with the charge simulation method and the finite element method are performed for a comparison with measured practical data obtained from a 525 kV power transmission line, located in the Southern area of Brazil. The comparison methodology is quantitative and based on concepts of ...
Tópico(s): Electromagnetic Compatibility and Noise Suppression
2018 - Institute of Electrical and Electronics Engineers | IEEE Latin America Transactions