Jesús Gago, Fernando Lahuerta, Pilar Antelo,
In order to assess the situation of beach litter on the Galician coast (NW Spain), we conducted a seasonal series of sampling on three beaches: A Lanzada, Baldaio and O Rostro.A total of 79 surveys were conducted from 2001 to 2010 on a stretch of 100 m and a stretch of 1 km.A total of 37862 beach litter items were counted and classified on the 100-m stretch and 7845 on the 1-km stretch.The average annual value of litter items for the 100-m beach stretch was 1016±633, 88±31 and 332±183; for the 1- ...
Tópico(s): Marine Biology and Environmental Chemistry
2014 - Spanish National Research Council | Scientia Marina
Nuno Basílio, Ana Fernandes, Víctor de Freitas, Sandra Gago, Fernando Piña,
The pH dependence of the network of chemical reactions involving 3′,4′,7-trihydroxyflavylium was studied and all the rate and equilibrium constants were determined in the presence and absence of β-cyclodextrin. The β-cyclodextrin increases the rate constant of the flavylium cation hydration to give the hemiketal and decreases the reverse rate constant (de-hydration). The quantum yield of the flavylium cation formation from irradiation of the trans-chalcone increases from 0.023 to 0.055, respectively, ...
Tópico(s): Photochromic and Fluorescence Chemistry
2013 - Royal Society of Chemistry | New Journal of Chemistry
Ana Merchán, Ana Sánchez-Kuhn, Ángeles Prados-Pardo, Belén Gago, Fernando Sánchez-Santed, Margarita Moreno, Pilar Flores,
Schedule-induced polydipsia (SIP), characterized by the development of persistent and excessive drinking under intermittent food-reinforcement schedules, is an animal model of compulsive behavior that can differentiate two populations: high drinkers (HD) and low drinkers (LD). The aim of the present study was to identify behavioral and biological markers to predict the vulnerability to developing compulsive-like drinking in SIP. Adult male Wistar rats were first trained in a spatial-discrimination ...
Tópico(s): Stress Responses and Cortisol
2019 - Elsevier BV | Progress in Neuro-Psychopharmacology and Biological Psychiatry
Diana Patricia Uscanga-Sosa, María B. Pérez‐Gago, Fernando Carlos Gómez-Meriño, José Andrés Herrera‐Corredor, Aleída Selene Hernández-Cázares, Adriana Contreras‐Oliva,
Minimal processing of eggplant (Solanum melongena L.) generates loss of firmness and polyphenol oxidase catalyzes the oxidation of phenolic compounds producing enzymatic browning. The aim of this study was to evaluate the effect of 1% ascorbic acid and 2% calcium ascorbate in aqueous solution at natural pH of the antioxidant (pH 2.6 and 7.8, respectively), or adjusted to pH 5 with generally recognized as safe substances, mantaining the quality of minimally processed eggplant stored at 5 °C for 6 d. ...
Tópico(s): Postharvest Quality and Shelf Life Management
2020 - Academic Press | Notulae Botanicae Horti Agrobotanici Cluj-Napoca
Niranjan Thatte, Mathias Tecza, Fraser Clarke, Roger L. Davies, Alban Remillieux, Roland Bacon, David Lunney, S. Arribas, E. Mediavilla, Fernando Gago, Naidu Bezawada, Pierre Ferruit, A. Fragoso, David Freeman, Javier Fuentes, Thierry Fusco, Angus Gallie, Adolfo Garcia, T. Goodsall, Félix Gracia, Aurélien Jarno, Johan Kosmalski, James Lynn, Stuart McLay, David Montgomery, A. Pécontal, Hermine Schnetler, Harry Smith, Dario Sosa, G. Battaglia, Neil E. Bowles, L. Colina, Éric Emsellem, Ana Garcia-Perez, Szymon Gładysz, I. Hook, P. G. J. Irwin, M. J. Jarvis, Robert C. Kennicutt, A. J. Levan, A. J. Longmore, John Magorrian, M. J. McCaughrean, L. Origlia, R. Rébolo, D. Rigopoulou, Sean G. Ryan, A. M. Swinbank, Nial Tanvir, Eline Tolstoy, A. Verma,
We describe the results of a Phase A study for a single field, wide band, near-infrared integral field spectrograph for the European Extremely Large Telescope (E-ELT).HARMONI, the High Angular Resolution Monolithic Optical & Nearinfrared Integral field spectrograph, provides the E-ELT's core spectroscopic requirement.It is a work-horse instrument, with four different spatial scales, ranging from seeing to diffraction-limited, and spectral resolving powers of 4000, 10000 & 20000 covering the 0.47 to 2. ...
Tópico(s): Adaptive optics and wavefront sensing
2010 - SPIE | Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE
F. Garzón, D. Abreu, Sonia Barrera, S. Becerril, L. M. Cairós, J. J. Díaz, A. Fragoso, Fernando Gago, R. Grangé, Carlos E. Martín González, P. López, J. Patrón, J. Pérez, J. L. Rasilla, P. Redondo, René Restrepo, P. Saavedra, V. Sánchez, F. Tenegi, M. Vallbé,
EMIR, currently entering into its fabrication and AIV phase, will be one of the first common user instruments for the GTC, the 10 meter telescope under construction by GRANTECAN at the Roque de los Muchachos Observatory (Canary Islands, Spain). EMIR is being built by a Consortium of Spanish and French institutes led by the Instituto de Astrofisica de Canarias (IAC). EMIR is designed to realize one of the central goals of 10m class telescopes, allowing observers to obtain spectra for large numbers ...
Tópico(s): Advanced optical system design
2006 - SPIE | Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE
P. La Penna, E. Aller Carpentier, Javier Argomedo, R. Arsenault, Ralf Conzelmann, B. Delabre, Rob Donaldson, Fernando Gago, P. Gutierrez-Cheetam, N. Hubin, Paul Jolley, M. Kiekebusch, Jean-Paul Kirchbauer, Barbara Klein, Johann Kolb, H. Kuntschner, Miska Le Louarn, Jean-Louis Lizon, P. Y. Madec, A. Manescau, Leander Mehrgan, Sylvain Oberti, J. Quentin, B. Sedghi, Stefan Ströbele, M. Suárez Valles, C. Soenke, Sébastien Tordo, J. Vernet,
GALACSI is the Adaptive Optics (AO) module that will serve the MUSE Integral Field Spectrograph. In Wide Field Mode it will enhance the collected energy in a 0.2"×0.2" pixel by a factor 2 at 750 nm over a Field of View (FoV) of 1'×1' using the Ground Layer AO (GLAO) technique. In Narrow Field Mode, it will provide a Strehl Ratio of 5% (goal 10%) at 650 nm, but in a smaller FoV (7.5"×7.5" FoV), using Laser Tomography AO (LTAO). Before being ready for shipping to Paranal, the system has gone through an ...
Tópico(s): Infrared Target Detection Methodologies
2016 - SPIE | Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE
Michael H. Goerz, Daniel Basilewitsch, Fernando Gago-Encinas, Matthias Krauß, Karl P. Horn, Daniel M. Reich, Christiane P. Koch,
We present a new open-source Python package, krotov, implementing the quantum optimal control method of that name. It allows to determine time-dependent external fields for a wide range of quantum control problems, including state-to-state transfer, quantum gate implementation and optimization towards an arbitrary perfect entangler. Krotov's method compares to other gradient-based optimization methods such as gradient-ascent and guarantees monotonic convergence for approximately time-continuous ...
Tópico(s): Laser-Matter Interactions and Applications
2019 - SciPost.org | SciPost Physics
Edoardo Caronna, Victor J Gallardo, Gabriella Egeo, M. Millán Vázquez, Candela Nieves Castellanos, Javier A. Membrilla, Gloria Vaghi, Joana Rodríguez-Montolio, Neus Fabregat Fabra, Francisco Sánchez-Caballero, Alex Jaimes Sánchez, Albert Muñoz‐Vendrell, Renato Oliveira, Gabriel Gárate, Yésica González‐Osorio, Daniel Guisado‐Alonso, Raffaele Ornello, Cem Thunstedt, Iris Fernández-Lázaro, Marta Torres‐Ferrús, Alicia Alpuente, Paola Torelli, Cinzia Aurilia, Raquel Lamas Pére, Maria José Ruiz Castrillo, Roberto De Icco, Grazia Sances, Sarah Broadhurst, Hui Ching Ong, Andrea Gómez García, Sergio Campoy, Jordi Sanahuja, Gonçalo Cabral, Isabel Beltrán Blasco, Marta Waliszewska‐Prosół, Liliana Pereira, Almudena Layos-Romero, Isabel Luzeiro, Laura Dorado, María Escudero, Arne May, A. López-Bravo, Isabel Pavão Martins, Christina Sundal, Pablo Irimia, Alberto Lozano Ros, Ana Beatriz Gago‐Veiga, Fernando Velasco Juanes, Ruth Ruscheweyh, Simona Sacco, Elisa Cuadrado‐Godia, David García‐Azorín, Julio Pascual, Raquel Gil‐Gouveia, Mariano Huerta Villanueva, Jaime Rodríguez-Vico, J. Viguera Romero, Vı́ctor Obach, Sonia Santos‐Lasaosa, Mona Ghadiri–Sani, Cristina Tassorelli, Javier Díaz de Terán, Samuel Díaz Insa, C. González Oria, Piero Barbanti, Patricia Pozo‐Rosich,
Background Anti-CGRP monoclonal antibodies (anti-CGRP MAbs) are approved and available treatments for migraine prevention. Patients do not respond alike and many countries have reimbursement policies, which hinder treatments to those who might respond. This study aimed to investigate clinical factors associated with good and excellent response to anti-CGRP MAbs at 6 months. Methods European multicentre, prospective, real-world study, including high-frequency episodic or chronic migraine (CM) patients ...
Tópico(s): Trigeminal Neuralgia and Treatments
2024 - BMJ | Journal of Neurology Neurosurgery & Psychiatry
Francisco Pedro García Fernández, Pedro Luis Pancorbo Hidalgo, José Verdú Soriano, J. Javier Soldevilla Ágreda, Manuel Rodríguez Palma, Manuel Gago Fornells, Fernando Martínez Cuervo, Justo Rueda López,
UNA REVISIÓN SISTEMÁTICA CON METAANÁLISIS no difference in the clinical efficiency between different types of MET products.Foams advantage HCL in comfort and exudates absorption.
Tópico(s): Pressure Ulcer Prevention and Management
2007 - Ediciones SPA S.L. | Gerokomos
Beatriz Sánchez, M. Aguiar-González, Roberto Barreto, S. Becerril, Joss Bland‐Hawthorn, Á. Bongiovanni, J. Cepa, Santiago Correa, Oscar Chapa, A. Ederoclite, Carlos Espejo, Alejandro Farah, A. Fragoso, P. B. Fernandez, Rubén Higueras Flores, F. Javier Fuentes, Fernando Gago, F. Garfias, José V. Gigante, J. González‐Hernández, V. González-Escalera, Belén Hernández, Elvio Hernández, Alberto Herrera, Guillermo Herrera, E. Joven, R. Langarica, Gerardo Lara, José Carlos López Vázquez, Roberto López López, Carmelo Militellon, H. Moreno, Lorenzo Peraza, Ángeles Pérez, Jaime Pérez, José Luis Rasilla, J. Rosich, Carlos Tejada, Silvio Tinoco, Txinto Vaz, Alejandro Villegas,
OSIRIS (Optical System for Imaging and low Resolution Integrated Spectroscopy) was the optical Day One instrument for the 10.4m Spanish telescope GTC. It is installed at the Observatorio del Roque de Los Muchachos (La Palma, Spain). This instrument has been operational since March-2009 and covers from 360 to 1000 nm. OSIRIS observing modes include direct imaging with tunable and conventional filters, long slit and low resolution spectroscopy. OSIRIS wide field of view and high efficiency provide a ...
Tópico(s): Adaptive optics and wavefront sensing
2012 - SPIE | Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE
Luis Fernando Rodríguez-Ramos, Teodora Viera, José V. Gigante, Fernando Gago, Guillermo Herrera, A. Alonso, Nicolas Descharmes,
FPGA (Field Programmable Gate Array) technology has become a very powerful tool available to the electronic designer, specially after the spreading of high quality synthesis and simulation software packages at very affordable prices. They also offer high physical integration levels and high speed, and eases the implementation of parallelism to obtain superb features. Adaptive optics for the next generation telescopes (50-100 m diameter) -or improved versions for existing ones- requires a huge amount ...
Tópico(s): Advanced optical system design
2005 - SPIE | Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE
Michael De Rosa, Gustavo Cabrera Nieto, Fernando Ferrer Gago,
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffect of N-chloro structure and 1-substituent on .sigma.-substitution (addition-elimination) in pyrrolesMichael De Rosa, Gustavo Cabrera Nieto, and Fernando Ferrer GagoCite this: J. Org. Chem. 1989, 54, 22, 5347–5350Publication Date (Print):October 1, 1989Publication History Published online1 May 2002Published inissue 1 October 1989https://pubs.acs.org/doi/10.1021/jo00283a032https://doi.org/10.1021/jo00283a032research-articleACS PublicationsRequest reuse ...
Tópico(s): Porphyrin and Phthalocyanine Chemistry
1989 - American Chemical Society | The Journal of Organic Chemistry
W. Hackenberg, Domenico Bonaccini Calia, Bernard Buzzoni, Mauro Comin, Christophe Dupuy, Fernando Gago, Ivan Guidolin, Ronald Guzman, Ronald Holzloehner, L. Kern, J. -P. Kirchbauer, S.A.E. Lewis, J. L. Lizon, Stewart McLay, Thomas Pfrommer, Marco Quattri, J. Quentin, R. Ridings,
The Four Laser Guide Star Facility (4LGSF) is part of the ESO Adaptive Optics Facility, in which one of the VLT telescopes, UT4, is transformed in an adaptive telescope-equipped with a deformable secondary mirror, two adaptive optics systems at the Nasmyth focii and four sodium laser guide star modular units. In this paper we present the design, the assembly and validation test performed so far in Europe on the first laser guide star unit.
Tópico(s): Advanced optical system design
2014 - SPIE | Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE
Victoria Valdes, Manuel Gago Fornells, R. Fernando García González, A.J. Guijón del Castillo, Alexa Gutierrez, J-E. Torra i Bou,
A patient with diabetes who burnt his feet by walking on hot sand was treated with an amorphous hydrogel, which resulted in full wound healing within four weeks. These patients should avoid walking barefoot on sand whenever possible
Tópico(s): Tendon Structure and Treatment
2002 - Mark Allen Group | Journal of Wound Care
Isabel S. Gonçalves, André D. Lopes, Tatiana R. Amarante, Filipe A. Almeida Paz, Nuno J. O. Silva, Martyn Pillinger, Sandra Gago, Fernando Palacio, Fritz E. Kühn, Carlos C. Romão,
The reaction of FeI(2) with two equivalents of AgReO(4) in acetonitrile leads to yellow, crystalline Fe(ReO(4))(2)(CH(3)CN)(3) (1), and the treatment of 1 with four equivalents of CpFe(CO)(2)CN gives orange, crystalline Fe(ReO(4))(2)[CpFe(CO)(2)(CN)](4) (2). Compound 2 can also be prepared in one step by the reaction of FeI(2), AgReO(4) and CpFe(CO)(2)CN in dichloromethane. The structure of 1 consists of infinite chains in which alternating {Fe(CH(3)CN)(4)} and {Fe(ReO(4))(2)(CH(3)CN)(2)} units are ...
Tópico(s): Organometallic Complex Synthesis and Catalysis
2009 - Royal Society of Chemistry | Dalton Transactions
Manuel Castro‐Gago, Carmen Gómez‐Lado, Fernando Lopez Alvez, A. Alonso, Begoña Vieites,
Juvenile xanthogranuloma is a form of histiocytic proliferative disorder that usually affects the skin and tends to occur during infancy. On rare occasions, it has been reported at extracutaneous sites and in other age groups. Isolated juvenile xanthogranuloma of the nervous system is extremely rare, especially in the cauda equina. A case of juvenile xanthogranuloma of the cauda equina in a 14-year-old boy is reported, and the literature is reviewed. Juvenile xanthogranuloma is a form of histiocytic ...
Tópico(s): Vascular Malformations and Hemangiomas
2009 - Elsevier BV | Pediatric Neurology
Nuno Basílio, Sandra Gago, A. Jorge Parola, Fernando Piña,
Cucurbit[7]uril inclusion complexes with guests bearing dimethylamino groups show the expected upward pKa shifts, whereas their diethylamino counterparts display a decrease in pKa due to the preferential stabilization of the unprotonated form. These results identify the diethylamino group as the substituent of choice to avoid receptor-assisted protonation of guest molecules and present new evidence for the role of the hydrophobic effect as a driving force in cucurbituril complexation.
Tópico(s): Molecular Sensors and Ion Detection
2017 - American Chemical Society | ACS Omega
Marcos Reyes García-Talavera, José Antonio Rodríguez, Teodora Viera, Heidi Moreno-Arce, Jose L. Rasilla, Fernando Gago, Luis F. Rodríguez, Panchita Gomez, Ezequiel Ballesteros Ramirez,
The European Space Agency (ESA) has undertaken the development of Optical Data Relay payloads, aimed at establishing free space optical communication links between satellites. The first of such systems put into orbit is the SILEX project, in which an experimental link between a GEO satellite (ARTEMIS) and a LEO satellite (SPOT IV) will be used to relay earth observation data. In order to perform In Orbit Testing (IOT) of these and future optical communications systems, ESA and the Instituto de Astrofisica ...
Tópico(s): Space Satellite Systems and Control
2002 - SPIE | Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE
Luis Fernando Rodríguez-Ramos, Teodora Viera, Guillermo Herrera, José V. Gigante, Fernando Gago, A. Alonso,
Real-time control has been clearly identified as a separate challenging field within Adaptive Optics, where a lot of computations have to be performed at kilohertz rate to properly actuate the mirror(s) before the input wavefront information has become obsolete. When considering giant telescopes, the number of guide stars, wavefront samples and actuators rises to a level where the amount of processing is far from being manageable by today's conventional processors and even from the expectations ...
Tópico(s): Stellar, planetary, and galactic studies
2006 - SPIE | Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE
V. Oviedo Gómez, Luisa Sánchez García, Paula Martín Escuer, E. Hernández García, Josefa Martín Gago, Fernando Perez, J.M. Monfá Bosch,
Tópico(s): Cerebrospinal fluid and hydrocephalus
2010 - Elsevier BV | Nefrología
J. Bartual, María B. Pérez‐Gago, Fernando Pomares, Lluı́s Palou, Diego S. Intrigliolo,
Pomegranate (Punica granatum L.) is a deciduous fruit tree native of central Asia included in the so-called group of minor fruit tree species. Although not widely grown, it has some importance in the east and southeast of Spain, where there are about 3100 ha of commercially cultivated pomegranates. In semi-arid climate areas like Spain, irrigation management is a powerful tool to influence tree water status agronomic performance and fruit composition. The present research focused on determining the ...
Tópico(s): Horticultural and Viticultural Research
2015 - International Society for Horticultural Science | Acta Horticulturae
M. Balcells, R. Guzmán, J. Patrón, Alfonso Aragón‐Salamanca, J. Azcue, Jose A. Ballester Lluch, M. T. Barroso, F. Beigbeder, Sylvie Brau-Nogué, N. Cardiel, Dave Carter, J. J. Díaz, E. De la Fuente, F. Javier Fuentes, Ana B. Fragoso-López, Fernando Gago, J. Gallego, Javier Gómez‐Elvira, J. C. Heredero, Damien Jones, José Carlos López Vázquez, Peter Luke, A. Manescau, Tamara Muñoz, R. F. Peletier, R. Pelló, J. P. Picat, David J. Robertson, José Antonio Rodríguez, Ángel Serrano, R. M. Sharples, J. Zamorano,
EMIR is a near-IR, multi-slit camera-spectrograph under development for the 10m GTC on La Palma. It will deliver up to 45 independent R equals 3500-4000 spectra of sources over a field of view of 6 feet by 3 feet, and allow NIR imaging over a 6 foot by 6 foot FOV, with spatial sampling of 0.175 inch/pixel. The prime science goal of the instrument is to open K-band, wide field multi-object spectroscopy on 10m class telescopes. Science applications range from the study of star-forming galaxies beyond ...
Tópico(s): Astronomical Observations and Instrumentation
2000 - SPIE | Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE
Ziad Zoghby, JosephP. Grande, M. Gago Fraile, Suzanne M. Norby, Fernando C. Fervenza, Borja G. Cosío,
Membranous nephropathy (MN) recurs posttransplant in 42% of patients. We compared MN recurrence rates in a historical cohort transplanted between 1990 and 1999 and in a current cohort diagnosed by protocol biopsies, we analyzed the progression of the disease and we assessed the effects of anti-CD20 antibodies (Rituximab) on recurrent MN. The incidence of recurrent MN was similar in the historical (53%) and the current cohorts (41%), although in the later the diagnosis was made earlier (median, 4[2-21] ...
Tópico(s): Renal and Vascular Pathologies
2009 - Elsevier BV | American Journal of Transplantation
Yaw Sing Tan, Judith Reeks, Christopher J. Brown, Dawn Thean, Fernando Jose Ferrer Gago, Tsz Ying Yuen, Eunice Tze Leng Goh, Xue Er Cheryl Lee, Claire Jennings, Thomas L. Joseph, Rajamani Lakshminarayanan, David P. Lane, M.E.M. Noble, Chandra Verma,
Protein flexibility poses a major challenge in binding site identification. Several computational pocket detection methods that utilize small-molecule probes in molecular dynamics (MD) simulations have been developed to address this issue. Although they have proven hugely successful at reproducing experimental structural data, their ability to predict new binding sites that are yet to be identified and characterized has not been demonstrated. Here, we report the use of benzenes as probe molecules ...
Tópico(s): Enzyme Structure and Function
2016 - American Chemical Society | The Journal of Physical Chemistry Letters
Alejandro Losada, María José Muñoz-Alonso, Marta Martínez, Federico Gago, Juan Manuel Domı́nguez, Juan Fernando Martínez-Leal, Carlos M. Galmarini,
Through several not-fully-characterised moonlighting functions, translation elongation factor eEF1A2 is known to provide a fitness boost to cancer cells. Furthermore, eEF1A2 has been demonstrated to confer neoplastic characteristics on preneoplastic, nontumourigenic precursor cells. We have previously shown that eEF1A2 is the target of plitidepsin, a marine drug currently in development for cancer treatment. Herein, we characterised a new signalling pathway through which eEF1A2 promotes tumour cell ...
Tópico(s): interferon and immune responses
2018 - Springer Nature | British Journal of Cancer
Tsz Ying Yuen, Christopher J. Brown, Yuezhen Xue, Yaw Sing Tan, Fernando Jose Ferrer Gago, Xue Er Lee, Jin Yong Neo, Dawn Thean, Hung Yi Kristal Kaan, Anthony W. Partridge, Chandra Verma, David P. Lane, Charles W. Johannes,
All-hydrocarbon, i, i+7 stapled peptide inhibitors of the p53-Mdm2 interaction have emerged as promising new leads for cancer therapy. Typical chemical synthesis via olefin metathesis results in the formation of both E- and Z-isomers, an observation that is rarely disclosed but may be of importance in targeting PPI. In this study, we evaluated the effect of staple geometry on the biological activity of five p53-reactivating peptides. We also present strategies for the modulation of the E/Z ratio ...
Tópico(s): Cancer-related Molecular Pathways
2019 - Royal Society of Chemistry | Chemical Science
Srinivasaraghavan Kannan, Pietro G. A. Aronica, Simon Ng, Dawn Thean Gek Lian, Yuri Frosi, Sharon Chee, Shimin Jiang, Tsz Ying Yuen, Ahmad Sadruddin, Hung Yi Kristal Kaan, Arun Chandramohan, Jin Huei Wong, Yaw Sing Tan, Zi Wei Chang, Fernando J. Ferrer‐Gago, Prakash Arumugam, Yi Han, Shiying Chen, Laurent Rénia, Christopher J. Brown, Charles W. Johannes, Brian Henry, David P. Lane, Tomi K. Sawyer, Chandra Verma, Anthony W. Partridge,
Peptide-based molecules hold great potential as targeted inhibitors of intracellular protein-protein interactions (PPIs). Indeed, the vast diversity of chemical space conferred through their primary, secondary and tertiary structures allows these molecules to be applied to targets that are typically deemed intractable via small molecules. However, the development of peptide therapeutics has been hindered by their limited conformational stability, proteolytic sensitivity and cell permeability. Several ...
Tópico(s): Glycosylation and Glycoproteins Research
2020 - Royal Society of Chemistry | Chemical Science
Simon Ng, Yu‐Chi Juang, Arun Chandramohan, Hung Yi Kristal Kaan, Ahmad Sadruddin, Tsz Ying Yuen, Fernando J. Ferrer‐Gago, Xue’Er Cheryl Lee, Xi Liew, Charles W. Johannes, Christopher J. Brown, Srinivasaraghavan Kannan, Pietro G. A. Aronica, Nils Berglund, Chandra Verma, Lijuan Liu, Alexander Stoeck, Tomi K. Sawyer, Anthony W. Partridge, David P. Lane,
Nonspecific promiscuous compounds can mislead researchers and waste significant resources. This phenomenon, though well-documented for small molecules, has not been widely explored for the peptide modality. Here we demonstrate that two purported peptide-based KRas inhibitors, SAH-SOS1A and cyclorasin 9A5, exemplify false-positive molecules—in terms of both their binding affinities and cellular activities. Through multiple gold-standard biophysical techniques, we unambiguously show that both peptides ...
Tópico(s): Biochemical and Structural Characterization
2020 - American Chemical Society | ACS Medicinal Chemistry Letters
Patrik Johansson, Cecilia Krona, Soumi Kundu, Milena Doroszko, Sathishkumar Baskaran, Linnéa Schmidt, Claire Vinel, Elin Almstedt, Ramy Elgendy, Ludmila Elfineh, Caroline J. Gallant, Sara Lundsten, Fernando Jose Ferrer Gago, Aleksi Hakkarainen, Petra Sipilä, Maria Häggblad, Ulf Märtens, Bo Lundgren, Melanie M. Frigault, David P. Lane, Fredrik J. Swartling, Lene Uhrbom, Marika Nestor, Silvia Marino, Sven Nelander,
Glioblastoma (GBM) is a malignant brain tumor with few therapeutic options. The disease presents with a complex spectrum of genomic aberrations, but the pharmacological consequences of these aberrations are partly unknown. Here, we report an integrated pharmacogenomic analysis of 100 patient-derived GBM cell cultures from the human glioma cell culture (HGCC) cohort. Exploring 1,544 drugs, we find that GBM has two main pharmacological subgroups, marked by differential response to proteasome inhibitors ...
Tópico(s): Ubiquitin and proteasome pathways
2020 - Cell Press | Cell Reports