Fernando Llorente, Luca Martino, David Delgado‐Gómez, J. López‐Santiago,
This is an up-to-date introduction to, and overview of, marginal likelihood computation for model selection and hypothesis testing. Computing normalizing constants of probability models (or ratios of constants) is a fundamental issue in many applications in statistics, applied mathematics, signal processing, and machine learning. This article provides a comprehensive study of the state of the art of the topic. We highlight limitations, benefits, connections, and differences among the different techniques. ...
Tópico(s): Statistical Methods and Bayesian Inference
2023 - Society for Industrial and Applied Mathematics | SIAM Review
Silvia Cámara, Ma Concepción Fournier, Patricia Cordero‐Andrés, Javier Melero Llorente, Fernando Bermejo, Borja Esteso, Ma Teresa Vara, Serafín Rodríguez, Álvaro Lassaletta, Marcelo Budke,
Tópico(s): Fetal and Pediatric Neurological Disorders
2019 - Springer Science+Business Media | The Cerebellum
Héctor Javier García Llorente, Fernando Martínez Abad, María José Rodríguez Conde,
Este estudio pretende validar un cuestionario de autopercepción sobre competencias relacionadas con la alfabetización informacional, aplicado a 1422 estudiantes de educación secundaria, de entre 14 y 17 años de edad, en las provincias de Palencia, Valladolid y Soria, así como contrastar la influencia de los estudios del padre y la madre sobre el nivel alcanzado en las dimensiones que forman el constructo competencia informacional. El instrumento final se compone de 18 ítems divididos en 4 dimensiones. ...
Tópico(s): E-Learning and Knowledge Management
2019 - University of Murcia | Anales de Documentación
Miriam Bermúdez-Brito, Sergio Muñoz‐Quezada, Carolina Gómez‐Llorente, Fernando Romero, Ángel Gil,
The intestinal immune system maintains a delicate balance between immunogenicity against invading pathogens and tolerance to the commensal microbiota and food antigens. Different strains of probiotics possess the ability to finely regulate the activation of dendritic cells (DC), polarising the subsequent activity of T-cells. Nevertheless, information about their underlying mechanisms of action is scarce. In the present study, we investigated the immunomodulatory effects of a potentially probiotic ...
Tópico(s): Infant Nutrition and Health
2014 - Cambridge University Press | British Journal Of Nutrition
Xavier Santos, Marta Vidal‐García, José Carlos Brito, Soumía Fahd, Gustavo A. Llorente, Fernando Martínez‐Freiría, Xavier Parellada, Juan M. Pleguezuelos, Neftalí Sillero,
Tópico(s): Animal Ecology and Behavior Studies
2014 - Springer Science+Business Media | Evolutionary Ecology
José Luís Llorente, Fernando López, Carlos Suárez, Mario Hermsen,
Tópico(s): Oral and Maxillofacial Pathology
2014 - Nature Portfolio | Nature Reviews Clinical Oncology
José Luís Llorente, Fernando López, Vanessa Suárez, María Costales, Carlos Suárez,
Tópico(s): Underwater Vehicles and Communication Systems
2011 - Elsevier BV | Acta Otorrinolaringológica Española
Briardo Llorente, Fernando Bravo‐Almonacid, Cristina Cvitanich, Elżbieta Orłowska, Héctor N. Torres, M M Flawiá, G. Alonso,
To establish a reliable and rapid protocol to simultaneously obtain high quality DNA from an infected host plant and the infecting pathogen. To develop an accurate and sensitive low-cost assay for the quantification and in planta monitoring of Phytophthora infestans growth.In this study, we describe a SYBR Green-based quantitative real-time PCR (qPCR) method for the quantification of P. infestans. The method is based on a simultaneous plant-pathogen DNA purification followed by a qPCR in which the ...
Tópico(s): Plant Pathogens and Fungal Diseases
2010 - Oxford University Press | Letters in Applied Microbiology
Patricia Henríquez, Jesús B. Alonso, Miguel A. Ferrer, Carlos M. Travieso, Juan Ignacio Godino-Llorente, Fernando Díaz-de-Maria,
In this paper, we propose to quantify the quality of the recorded voice through objective nonlinear measures. Quantification of speech signal quality has been traditionally carried out with linear techniques since the classical model of voice production is a linear approximation. Nevertheless, nonlinear behaviors in the voice production process have been shown. This paper studies the usefulness of six nonlinear chaotic measures based on nonlinear dynamics theory in the discrimination between two ...
Tópico(s): Blind Source Separation Techniques
2009 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Audio Speech and Language Processing
Irene Llorente, Fernando Lizcano, R Alvarez, Nieves Díez, M. Sopena, M.J. Cancho Gil, Javier Salvador,
Controversy still exists regarding the role of cholinergic pathways in the regulation of the hypothalamic-pituitary-adrenal axis in man. We studied the effects of the administration of placebo, pyridostigmine (PD); 120 mg, orally), and the combination of PD and pirenzepine (PZP; 100 mg, orally) on ACTH, cortisol, and GH secretion at 0730 and 2230 h in seven normal males. PD induced a clear decrease in ACTH levels at both times of the day compared to treatment with placebo, producing higher suppression ...
Tópico(s): Olfactory and Sensory Function Studies
1996 - Oxford University Press | The Journal of Clinical Endocrinology & Metabolism
Antonio Vidaller, Luis Llorente, Fernando Larrea, Juan Pablo Méndez, Jorge Alcocer‐Varela, D Alarcón-Segovia,
We studied four patients with tumoral hyperprolactinemia and normal ovarian function before and after prolactine levels had become normal with treatment with bromocriptine (BrC), a dopamine agonist that inhibits prolactin release. Their proliferative responses to concanavalin A, pokeweed mitogen, and, to a lesser extent, phytohemagglutinin, their spontaneous and concanavalin A-induced suppression, and their production of interleukin 2 were found to be decreased and to correct partially or completely ...
Tópico(s): Cancer, Hypoxia, and Metabolism
1986 - Academic Press | Clinical Immunology and Immunopathology
José Luís Llorente, Fernando López, Marta Morato, Vanessa Suárez, Andrés Coca, Carlos Suárez,
Choanal atresia (CA) is an infrequent congenital obliteration of the airway at the level of the posterior nasal aperture resulting in the absence of connection between the nasal cavity and the aerodigestive tract. We present our experience with an endoscopic technique for congenital CA without the use of intranasal stents. We analysed a series of 10 patients with CA treated in our department from 2006 to 2012 through endoscopic surgery. We present a description of the sample and the surgical technique ...
Tópico(s): Tracheal and airway disorders
2013 - Elsevier BV | Acta Otorrinolaringologica (English Edition)
José Luís Llorente, Fernando López, Vanessa Suárez, María Costales, Carlos Suárez,
Juvenile nasopharyngeal angiofibroma (JNA) is a rare benign tumour in adolescent males. It may be associated with a significant morbidity because of its anatomical location and its locally destructive growth pattern. Severe haemorrhage constitutes a high risk in JNA and its surgical management could be complex.We retrospectively analysed the clinical data from 43 patients with JNA surgically treated in our Department from 1993 until 2010. Mean postoperative follow-up time was 85 months.Analysis was ...
Tópico(s): Tumors and Oncological Cases
2011 - Elsevier BV | Acta Otorrinolaringologica (English Edition)
Fernando Llorente, Luca Martino, David Delgado‐Gómez, Gustau Camps‐Valls,
Understanding systems by forward and inverse modeling is a recurrent topic of research in many domains of science and engineering. In this context, Monte Carlo methods have been widely used as powerful tools for numerical inference and optimization. They require the choice of a suitable proposal density that is crucial for their performance. For this reason, several adaptive importance sampling (AIS) schemes have been proposed in the literature. We here present an AIS framework called Regression- ...
Tópico(s): Advanced Multi-Objective Optimization Algorithms
2021 - Elsevier BV | Digital Signal Processing
Danae Carreras-García, David Delgado‐Gómez, Fernando Llorente, Ana Arribas‐Gil,
Nowadays, across the most important problems faced by health centers are those caused by the existence of patients who do not attend their appointments. Among others, these patients cause loss of revenue to the health centers and increase the patients’ waiting list. In order to tackle these problems, several scheduling systems have been developed. Many of them require predicting whether a patient will show up for an appointment. However, obtaining these estimates accurately is currently a challenging ...
Tópico(s): Healthcare Policy and Management
2020 - Multidisciplinary Digital Publishing Institute | Entropy
Fernando Llorente, Luca Martino, Vı́ctor Elvira, David Delgado‐Gómez, J. López‐Santiago,
Numerical integration and emulation are fundamental topics across scientific fields. We propose novel adaptive quadrature schemes based on an active learning procedure. We consider an interpolative approach for building a surrogate posterior density, combining it with Monte Carlo sampling methods and other quadrature rules. The nodes of the quadrature are sequentially chosen by maximizing a suitable acquisition function, which takes into account the current approximation of the posterior and the ...
Tópico(s): Control Systems and Identification
2020 - Institute of Electrical and Electronics Engineers | IEEE Access
Carlos Fernando Llorente, F. J. Betrán, A. J. Bockholt, F. Fojt,
Crop ScienceVolume 44, Issue 3 p. 1036-1037 Registration of Parental Line Registration of Tx772 Maize C.F. Llorente, C.F. Llorente O'Higgins 1452 PB"A", 1426, Buenos Aires, ArgentinaSearch for more papers by this authorF.J. Betrán, Corresponding Author F.J. Betrán javierbetran@tamu.edu Soil and Crop Sciences Dep., Texas A&M University, College Station, TX, 77843-2474Corresponding author (javierbetran@tamu.edu)Search for more papers by this authorA. Bockholt, A. Bockholt Soil and Crop Sciences Dep., ...
Tópico(s): Wheat and Barley Genetics and Pathology
2004 - Wiley | Crop Science
Fernando Llorente, Luca Martino, Ernesto Curbelo, J. López‐Santiago, David Delgado‐Gómez,
The application of Bayesian inference for the purpose of model selection is very popular nowadays. In this framework, models are compared through their marginal likelihoods, or their quotients, called Bayes factors. However, marginal likelihoods depends on the prior choice. For model selection, even diffuse priors can be actually very informative, unlike for the parameter estimation problem. Furthermore, when the prior is improper, the marginal likelihood of the corresponding model is undetermined. ...
Tópico(s): Statistical Methods and Bayesian Inference
2022 - Wiley | Wiley Interdisciplinary Reviews Computational Statistics
Héctor Javier García Llorente, Fernando Martínez Abad, María José Rodríguez Conde,
El objetivo de esta investigación ha sido realizar una evaluación de la autopercepción y de los desempeños específicos demostrados sobre competencias informacionales en alumnado de educación secundaria obligatoria. Para ello, se aplicaron dos cuestionarios a una muestra de 1422 estudiantes de entre 14 y 17 años de edad, de una región de alto rendimiento académico en España, como es el Programme for International Student Assessment (PISA) Junta de Castilla y Léon (2015). Los instrumentos de recogida ...
Tópico(s): E-Learning and Knowledge Management
2019 - National University, Costa Rica | Revista Electrónica Educare
José Luís Llorente, Fernando López, Marta Morato, Vanessa Suárez, Andrés Coca, Carlos Suárez,
Choanal atresia (CA) is an infrequent congenital obliteration of the airway at the level of the posterior nasal aperture resulting in the absence of connection between the nasal cavity and the aerodigestive tract. We present our experience with an endoscopic technique for congenital CA without the use of intranasal stents.We analysed a series of 10 patients with CA treated in our department from 2006 to 2012 through endoscopic surgery. We present a description of the sample and the surgical technique ...
Tópico(s): Teratomas and Epidermoid Cysts
2013 - Elsevier BV | Acta Otorrinolaringológica Española
Luca Martino, Fernando Llorente, Ernesto Curbelo, J. López‐Santiago, Joaquı́n Mı́guez,
We propose a novel adaptive importance sampling scheme for Bayesian inversion problems where the inference of the variables of interest and the power of the data noise are carried out using distinct (but interacting) methods. More specifically, we consider a Bayesian analysis for the variables of interest (i.e., the parameters of the model to invert), whereas we employ a maximum likelihood approach for the estimation of the noise power. The whole technique is implemented by means of an iterative procedure ...
Tópico(s): Gaussian Processes and Bayesian Inference
2021 - Multidisciplinary Digital Publishing Institute | Mathematics
M. Rosa Bernal‐López, Vicenta Llorente‐Cortés, Fernando Calleja, D. Lopez‐Carmona, Marı́a Dolores Mayas, Ricardo Gomez‐Huelgas, Lina Badimón, Francisco J. Tinahones,
Tópico(s): Biomarkers in Disease Mechanisms
2011 - Springer Science+Business Media | Acta Diabetologica
Fernando Llorente, Ernesto Curbelo, Luca Martino, Vı́ctor Elvira, David Delgado‐Gómez,
Monte Carlo sampling methods are the standard procedure for approximating complicated integrals of multidimensional posterior distributions in Bayesian inference. In this work, we focus on the class of Layered Adaptive Importance Sampling (LAIS) scheme, which is a family of adaptive importance samplers where Markov chain Monte Carlo algorithms are employed to drive an underlying multiple importance sampling scheme. The modular nature of LAIS allows for different possible implementations, yielding ...
Tópico(s): Bayesian Methods and Mixture Models
2022 - Elsevier BV | Applied Mathematical Modelling
José Luís Llorente, Fernando López, Vanessa Suárez, A. Fueyo, Susana Carnero-Sierra, Clara Martín, Victoria López, Daniel Camporro, Carlos Suárez,
La utilización de colgajos libres microvascularizados (CLM) se ha convertido en un método de reconstrucción frecuente en el área de cabeza y cuello debido a sus elevadas tasas de éxito y a sus mejores resultados funcionales. Presentamos nuestra experiencia en la reconstrucción de defectos complejos con CLM. Se presenta una serie de 246 pacientes que requirieron una reconstrucción con CLM entre 1991 y 2013. Se realizaron 259 intervenciones en 246 pacientes. El motivo más frecuente para la realización ...
Tópico(s): Reconstructive Facial Surgery Techniques
2013 - Elsevier BV | Acta Otorrinolaringológica Española
M. Rosa Bernal‐López, Lourdes Garrido‐Sánchez, Víctor Gómez Carrillo, Jose L. Gallego‐Perales, Vicenta Llorente‐Cortés, Fernando Calleja, Ricardo Gomez‐Huelgas, Lina Badimón, Francisco J. Tinahones,
Oxidized lipoproteins and antioxidized LDL antibodies (antioxLDL abs) have been detected in human plasma and atherosclerotic lesions. The principle aim of this study was to analyze the possible relationship between IgG and IgM antioxLDL abs and factors involved in different metabolic pathways (inflammation, lipid metabolism, apoptosis, and cell cycle arrest profile) in the occluded popliteal artery (OPA) compared with the femoral vein (FV).Fifteen patients with advanced atherosclerosis and type 2 diabetes ...
Tópico(s): Adipokines, Inflammation, and Metabolic Diseases
2012 - American Diabetes Association | Diabetes Care
Juan Ignacio Godino-Llorente, Fernando Cruz–Roldán, Manuel Blanco–Velasco, Rubén Fraile, Víctor Osma-Ruiz, Nicolás Sáenz-Lechón,
This paper presents the design and development of an on-demand low-cost positioning and tracking (P&T) system for large environments based on standard mobile phones and Global Positioning System (GPS)-enabled devices, which allows the position of a terminal to be tracked by exchanging text or multimedia messages using short message service (SMS) and/or multimedia message service (MMS). In contrast with other works in the state of the art, the presented method and system do not require an intermediate ...
Tópico(s): Bluetooth and Wireless Communication Technologies
2011 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Intelligent Transportation Systems
Viyey Doulatram‐Gamgaram, Sergio Valdés, Cristina Maldonado‐Araque, Ana Lago‐Sampedro, Rocío Badía-Guillén, Eva García‐Escobar, Sara García‐Serrano, Marta G. Vivanco, Juan Luis Garrido, Mark R. Theobald, Victoria Gil, Fernando Martín‐Llorente, Alfonso L. Calle‐Pascual, Elena Bordiú, Luís Castaño, Elías Delgado, Josep Franch‐Nadal, Felipe J. Chaves, Eduard Montanya, José Luis Galán–García, Gabriel Aguilera‐Venegas, Federico Soriguer, Gemma Rojo‐Martínez,
Abstract Exposure to air particulate matter has been linked with hypertension and blood pressure levels. The metabolic risks of air pollution could vary according to the specific characteristics of each area, and has not been sufficiently evaluated in Spain. We analyzed 1103 individuals, participants in a Spanish nationwide population based cohort study (di@bet.es), who were free of hypertension at baseline (2008–2010) and completed a follow-up exam of the cohort (2016–2017). Cohort participants were ...
Tópico(s): Air Quality Monitoring and Forecasting
2021 - Nature Portfolio | Scientific Reports
Miriam Bermúdez-Brito, Sergio Muñoz‐Quezada, Carolina Gómez‐Llorente, Esther Matencio, Fernando Romero, Ángel Gil,
The action of probiotics has been studied in vitro in cells isolated from both mice and humans, particularly enterocytes (IECs), dendritic cells (DCs) and co-cultures of peripheral DCs and IECs. Peripheral DCs and murine DCs differ from human gut DCs, and to date there are no data on the action of any probiotic on co-cultured human IECs and human intestinal DCs. To address this issue, a novel transwell model was used. Human IECs (Caco-2 cells) grown in the upper chamber of transwell filters were co- ...
Tópico(s): Viral gastroenteritis research and epidemiology
2015 - BioMed Central | BMC Microbiology
José Luís Llorente, Sergio Obeso, Fernando López, Juan Carlos Rial, Andrés Coca, Carlos Suárez,
Tópico(s): Facial Nerve Paralysis Treatment and Research
2013 - Springer Science+Business Media | European Archives of Oto-Rhino-Laryngology
Briardo Llorente, G. Alonso, Fernando Bravo‐Almonacid, Vanina Rodríguez, Mariana G. López, Fernando Carrari, Héctor N. Torres, Mirtha M. Flawiá,
It is expected that the next generation of biotech crops displaying enhanced quality traits with benefits to both farmers and consumers will have a better acceptance than first generation biotech crops and will improve public perception of genetic engineering. This will only be true if they are proven to be as safe as traditionally bred crops. In contrast with the first generation of biotech crops where only a single trait is modified, the next generation of biotech crops will add a new level of ...
Tópico(s): Plant tissue culture and regeneration
2010 - Wiley | Plant Biotechnology Journal