Nicolás Quezada, G Maturana, Eduardo Pimentel, Fernando Crovari, Rodrigo Muñoz, Nicolás Jarufe, Fernando Pimentel,
Tópico(s): Appendicitis Diagnosis and Management
2018 - Springer Science+Business Media | Hernia
Ricardo Mejía, Pablo Achurra, Mauricio Gabrielli, Eduardo Briceño, Rolando Rebolledo, Alberto Torres, Allan Sharp, Fernando Pimentel, Fernando Crovari,
Tópico(s): Bariatric Surgery and Outcomes
2016 - Springer Science+Business Media | Obesity Surgery
Casin Le, Camila Pimentel, Fernando Pasterán, Marisel R. Tuttobene, Tomás Subils, Jenny Escalante, Brent Nishimura, Susana Arriaga, Aimee Carranza, Vyanka Mezcord, Alejandro J. Vila, Alejandra Corso, Luis A. Actis, Marcelo E. Tolmasky, Robert A. Bonomo, María Soledad Ramirez,
Cefiderocol, a recently introduced antibiotic, has a chemical structure that includes a cephalosporin that targets cell wall synthesis and a chlorocatechol siderophore moiety that facilitates cell penetration by active iron transporters. Analysis of the effect that human serum, human serum albumin, and human pleural fluid had on growing Acinetobacter baumannii showed that genes related to iron uptake were down-regulated. At the same time, β-lactamase genes were expressed at higher levels. The minimum ...
Tópico(s): Enterobacteriaceae and Cronobacter Research
2022 - Multidisciplinary Digital Publishing Institute | Biomedicines
Produção Nacional
Revisado por pares
Ramón Silva, Tatiana Colombo Pimentel, Fernando Eustáquio de Matos, Erick A. Esmerino, Mônica Q. Freitas, Carmen Sílvia Fávaro-Trindade, Márcia Cristina Silva, Adriano G. Cruz,
The effect of sodium reduction and Lactobacillus acidophilus addition (free or microencapsulated) on the quality parameters of requeijão cremoso processed cheese was assessed for 90 days at 5 °C. Three formulations were prepared: (CONT) regular salt content and curd fusion (90 °C/2 min), (FREE) reduced salt content + free probiotic culture added after curd fusion (90 °C/2 min), and (MICRO) reduced salt content + microencapsulated probiotic culture added before curd fusion (70 °C/5 min). FREE and MICRO formulations ...
Tópico(s): Proteins in Food Systems
2021 - Elsevier BV | Food Bioscience
Dylan Nichols, Marja B. Pimentel, Fernando T. P. Borges, Sanjiv Hyoju, Fouad Teymour, Seok Hoon Hong, Olga Zaborina, John C. Alverdy, Georgia Papavasiliou,
Intestinal disease or surgical intervention results in local changes in tissue and host-derived factors triggering bacterial virulence. A key phenotype involved in impaired tissue healing is increased bacterial collagenase expression which degrades intestinal collagen. Antibiotic administration is ineffective in addressing this issue as it inadvertently eliminates normal flora while allowing pathogenic bacteria to "bloom" and acquire antibiotic resistance. Compounds that could attenuate collagenase ...
Tópico(s): Pharmacological Effects and Toxicity Studies
2019 - Frontiers Media | Frontiers in Bioengineering and Biotechnology
Miguel C. Leal, Tânia Pimentel, Fernando Ricardo, Rui Rosa, Ricardo Calado,
•Seafood traceability is critical for food safety but is still poorly implemented. •Biotechnology may assist in the fight against fraud and unregulated fisheries. •Traceability benefits producers and consumers through origin certification. Market globalization and recurring food safety alerts have resulted in a growing consumer awareness of the need for food traceability. This is particularly relevant for seafood due to its perishable nature and importance as a key protein source for the population ...
Tópico(s): Meat and Animal Product Quality
2015 - Elsevier BV | Trends in biotechnology
Produção Nacional
Revisado por pares
Marta Maria Menezes Bezerra Duarte, Graciliano de Oliveira Neto, Lauro T. Kubota, JoséL.L. Filho, Maria Fernanda Pimentel, Fernando Sanches de Lima, Valdinete Lins,
A potentiometric FIA system for penicillin determination, employing penicillinase [E.C. 3.5.2.6] immobilized on silica gel, packed into a reactor, was improved by the use of statistically designed experiments. A two-level and three-factor factorial was used to find the best working conditions evaluating the influence of some parameters on the signal response of the system and the number of determinations per hour. These parameters were analyzed individually obtaining two level of the variables to ...
Tópico(s): Antibiotics Pharmacokinetics and Efficacy
1997 - Elsevier BV | Analytica Chimica Acta
José Pimentel, Fernándo Marqués-García,
The mildew of the vineyards is prevented by the use of sprays with a solution of copper sulphate neutralized with hydrated lime. The inhalation of this solution while spraying may give rise to predominantly interstitial pulmonary lesions which may lead to respiratory insufficiency. These lesions, which were experimentally reproduced in guinea-pigs, have a well-defined histological picture characterized by three stages—intra-alveolar desquamation of macrophages, formation of predominantly histiocytic ...
Tópico(s): Occupational and environmental lung diseases
1969 - BMJ | Thorax
Produção Nacional
Revisado por pares
Virginia Genelhu, Bruno Miguel Jorge Celoria, Márcia Mattos Gonçalves Pimentel, Stênio Fernando Pimentel Duarte, Pedro Hernán Cabello, Emílio Antônio Francischetti,
This study assessed in obese Brazilians subjects whether a common variant of leptin gene, -2548G>A, is associated with blood pressure changes.A total of 140 subjects, 99 women; mean age of 45.2 +/- 12.4 years; body mass index (BMI) = 38.5 +/- 8.0 kg/m2 were included. Blood pressure was recorded using Dinamap 1846 (Critikon, Tampa, FL). Molecular analysis was made by use of PCR and restriction fragment-length polymorphism analysis. Plasma insulin and leptin concentrations were determined by radioimmunoassay.AA ...
Tópico(s): Biochemical Analysis and Sensing Techniques
2009 - Oxford University Press | American Journal of Hypertension
Elsa Vieira‐Sousa, Pedro Augusto Alves, Ana Maria Rodrigues, Filipa Teixeira, José Tavares‐Costa, A. Bernardo, Sofia Pimenta, Fernando Pimentel-Santos, João Lagoas Gomes, Renata Aguiar, Patrícia Pinto, Taciana Videira, Cristina Catita, Helena Santos, Joana Borges, Graça Sequeira, Célia Ribeiro, Lídia Teixeira, Pedro Ávila-Ribeiro, Fernando Martins, Helena Canhão, Iain B. McInnes, Ruy M. Ribeiro, João Eurico Fonseca,
Objectives To assess the efficacy of golimumab in combination with methotrexate (MTX) versus MTX monotherapy in psoriatic arthritis (PsA) dactylitis. Methods Multicentre, investigator-initiated, randomised, double-blind, placebo-controlled, parallel-design phase 3b trial in 11 Portuguese rheumatology centres. Patients with PsA along with active dactylitis and naive to MTX and biologic disease-modifying antirheumatic drugs (bDMARDs) were randomly assigned to golimumab or placebo, both in combination ...
Tópico(s): Autoimmune and Inflammatory Disorders Research
2020 - BMJ | Annals of the Rheumatic Diseases
Sofía Ramiro, Elena Nikiphorou, Alexandre Sepriano, Augusta Ortolan, Casper Webers, Xenofon Baraliakos, Robert Landewé, Filip Van den Bosch, B. Boteva, Ann Bremander, Philippe Carron, Adrian Ciurea, F. van Gaalen, Pál Géher, Lianne S. Gensler, Josef Hermann, Manouk de Hooge, Markéta Hušáková, Uta Kiltz, Clementina López‐Medina, Pedro Machado, Helena Marzo‐Ortega, Anna Moltó, Victoria Navarro‐Compán, Michael J. Nissen, Fernando Pimentel-Santos, Denis Poddubnyy, Fabian Proft, Martín Rudwaleit, Mark Telkman, Sizheng Steven Zhao, Nelly Ziadé, Désirée van der Heijde,
To update the Assessment of SpondyloArthritis international Society (ASAS)-EULAR recommendations for the management of axial spondyloarthritis (axSpA).Following the EULAR Standardised Operating Procedures, two systematic literature reviews were conducted on non-pharmacological and pharmacological treatment of axSpA. In a task force meeting, the evidence was presented, discussed, and overarching principles and recommendations were updated, followed by voting.Five overarching principles and 15 recommendations ...
Tópico(s): Autoimmune and Inflammatory Disorders Research
2022 - BMJ | Annals of the Rheumatic Diseases
Produção Nacional
Augusto Pimentel Pereira, Fernando Wollertt de França, Julianna Crippa, Braian Lucas Machado,
O Building Information Modeling (BIM) tem se apresentado como paradigma da construção civil nas últimas décadas e tem gerado reflexões a respeito do ensino no campo da arquitetura. No centro dessas reflexões está o fato de o ensino de BIM deve ir para além de uma capacitação meramente instrumental (Ruschel et al., 2013). Em especial pelo fato de que o BIM deve ser considerado em um contexto mais amplo, de um campo sociotécnico (Pereira & Procopiuck, 2022) que está permeado por dinâmicas políticas, processuais ...
Tópico(s): BIM and Construction Integration
2022 - | Encontro Nacional Sobre o Ensino de BIM
María Inés Gaete, Francisca Belmar, Matías Cortés, Adnan Alseidi, Domenech Asbun, Valentina Durán Espinoza, Gabriel Escalona, Pablo Achurra, Ignacio Villagrán, Fernando Crovari, Fernando Pimentel, Julián Varas,
Tópico(s): Augmented Reality Applications
2022 - Springer Science+Business Media | Surgical Endoscopy
Clementina López‐Medina, Anna Moltó, Joachim Sieper, Mehmet Tuncay Duruöz, Uta Kiltz, Bassel Elzorkany, N. Hajjaj‐Hassouni, Rubén Burgos‐Vargas, José A. Maldonado‐Cocco, Nelly Ziadé, Meghna Gavali, Victoria Navarro‐Compán, Shue-Fen Luo, Sara Monti, Taejong Kim, Mitsumasa Kishimoto, Fernando Pimentel-Santos, Jieruo Gu, Ruxandra Elena Schiotis, F. van Gaalen, Pál Géher, Marina Magrey, Sebastián Ibañez, Wilson Bautista‐Molano, Walter P. Maksymowych, Pedro Machado, Robert Landewé, Désirée van der Heijde, Maxime Dougados,
Objectives To characterise peripheral musculoskeletal involvement in patients with spondyloarthritis (SpA) including psoriatic arthritis (PsA), across the world. Methods Cross-sectional study with 24 participating countries. Patients with a diagnosis of axial SpA (axSpA), peripheral SpA (pSpA) or PsA according to their rheumatologist were included. The investigators were asked which diagnosis out of a list of six (axSpA, PsA, pSpA, inflammatory bowel disease-associated SpA, reactive arthritis or juvenile ...
Tópico(s): Psoriasis: Treatment and Pathogenesis
2021 - BMJ | RMD Open
Annelies Boonen, Polina Putrik, Mary Lucy Marques, Alessia Alunno, Lydia Abásolo, Dorcas Beaton, Neil Betteridge, Mathilda Björk, Maarten Boers, B. Boteva, Bruno Fautrel, Françis Guillemin, Elsa F Mateus, Elena Nikiphorou, Márta Péntek, Fernando Pimentel-Santos, Johannes L. Severens, Suzanne Verstappen, Karen Walker‐Bone, Johan K. Wallman, Marieke M. ter Wee, René Westhovens, Sofía Ramiro,
Clinical studies with work participation (WP) as an outcome domain pose particular methodological challenges that hamper interpretation, comparison between studies and meta-analyses.To develop Points to Consider (PtC) for design, analysis and reporting of studies of patients with inflammatory arthritis that include WP as a primary or secondary outcome domain.The EULAR Standardised Operating Procedures were followed. A multidisciplinary taskforce with 22 experts including patients with rheumatic diseases, ...
Tópico(s): Spondyloarthritis Studies and Treatments
2021 - BMJ | Annals of the Rheumatic Diseases
Rita Francisco, Carlota Pascoal, Dorinda Marques‐da‐Silva, Sandra Brasil, Fernando Pimentel-Santos, Ruqaiah Altassan, Jaak Jaeken, Ana Rita Grosso, Vanessa dos Reis Ferreira, Paula A. Videira,
Congenital disorders of glycosylation (CDG) are rare diseases with variable phenotypes and severity. Immunological involvement remains a largely uncharted topic in CDG, mainly due to lack of robust data. To better characterize immune-related manifestations’ prevalence, relevance, and quality-of-life (QoL) impact, we developed electronic questionnaires targeting (1) CDG patients and (2) the general “healthy” population. Two-hundred and nine CDG patients/caregivers and 349 healthy participants were included ...
Tópico(s): vaccines and immunoinformatics approaches
2020 - Multidisciplinary Digital Publishing Institute | Journal of Clinical Medicine
María de la Luz Cádiz‐Gurrea, Álvaro Fernández‐Ochoa, Francisco Javier Leyva‐Jiménez, Noelia Guerrero-Muñoz, María del Carmen Villegas-Aguilar, Sandra Pimentel-Moral, Fernando Ramos-Escudero, Antonio Segura‐Carretero,
Peru is one of the main areas where there are large cocoa crops with special relevance to the economy of this country. In fact, cocoa is a major, economically important, international crop which has been linked to several benefits, such as anti-allergenic, anti-atherogenic, anti-inflammatory, anti-microbial, anti-oxidant, anti-thrombotic, cardioprotective and vasodilatory properties, relating to its bioactive compound content. However, in cocoa industrial processing, several residues or wastes, ...
Tópico(s): Phytochemicals and Antioxidant Activities
2020 - Multidisciplinary Digital Publishing Institute | Molecules
Eduardo B. Cruz, Helena Canhão, Rita Fernandes, Carmen Caeiro, Jaime Branco, Ana Maria Rodrigues, Fernando Pimentel-Santos, Luís Antunes Gomes, Sofia Guerra-Paiva, Isabel Pinto, Rubina Moniz, Carla Nunes,
Non-specific low back pain (NSLBP) is the most prevalent musculoskeletal condition in western countries and is associated with persistent disability and high consumption of health care resources. NSLBP patients first seek primary health care services but the outcomes are often uncertain. This study aimed to examine the clinical course of the outcomes and to identify prognostic indicators for poor outcomes in NSLBP patients who consulted primary care.A prospective cohort study of 115 patients seeking ...
Tópico(s): Health Systems, Economic Evaluations, Quality of Life
2020 - Public Library of Science | PLoS ONE
Santiago Rodrigues-Manica, Alexandre Sepriano, Fernando Pimentel-Santos, Nélia Gouveia, Anabela Barcelos, Jaime Branco, Miguel Bernardes, Raquel Ferreira, Elsa Vieira‐Sousa, Sofia Barreira, Filipe Vinagre, Raquel Roque, Helena Santos, Nathalie Madeira, João Rovisco, Alexandra Daniel, Sofía Ramiro,
Abstract Background To investigate whether the reason to discontinue the first TNF inhibitor (TNFi) affects the response to the second TNFi in axial spondyloarthritis (axSpA). Methods Patients with axSpA from the Rheumatic Diseases Portuguese Register (ReumaPt), who discontinued their first TNFi and started the second TNFi between June 2008 and May 2018, were included. Response was assessed by the Ankylosing Spondylitis Disease Activity Score (ASDAS) clinically important improvement (ASDAS-CII), major ...
Tópico(s): Autoimmune and Inflammatory Disorders Research
2020 - BioMed Central | Arthritis Research & Therapy
Ana Valido, Carolina Lage Crespo, Fernando Pimentel-Santos,
Sarcopenia is a syndrome defined as a progressive and generalized skeletal muscle disorder associated with increased likelihood of adverse outcomes as falls, fractures, physical disability and death. The actual definition of sarcopenia is based in reduction of measures for three parameters- strength, muscle mass quantity or quality and physical performance (the determinat of severity). Muscle wasting is a common feature in several chronic diseases, such as spondyloarthritis (SpA), that significantly ...
Tópico(s): Autoimmune and Inflammatory Disorders Research
2019 - Frontiers Media | Frontiers in Medicine
Produção Nacional
Revisado por pares
Lúcio Huebra Pimentel Filho, Fernando Morgadinho Santos Coelho, Flávio Moura Rezende Filho, Orlando Graziani Póvoas Barsottini, José Luiz Pedroso,
Tópico(s): Glycogen Storage Diseases and Myoclonus
2019 - Springer Science+Business Media | Current Neurology and Neuroscience Reports
Lúcia Domingues, Fernando Pimentel-Santos, Eduardo B. Cruz, Ana Cristina Sousa, Ana Paula Pires dos Santos, Ana Beatriz Gomes Cordovil, Anabela Correia, Laura Sa Torres, Antônio Augusto Moura da Silva, Pedro Soares Branco, Jaime Branco,
The aim of this study was to compare the effectiveness of a combined intervention of manual therapy and exercise (MET) versus usual care (UC), on disability, pain intensity and global perceived recovery, in patients with non-specific chronic neck pain (CNP).Randomized controlled trial.Outpatient care units.Sixty-four non-specific CNP patients were randomly allocated to MET (n = 32) or UC (n = 32) groups.Participants in the MET group received 12 sessions of mobilization and exercise, whereas the UC group ...
Tópico(s): Acupuncture Treatment Research Studies
2019 - SAGE Publishing | Clinical Rehabilitation
Elsa Vieira‐Sousa, João Cavaleiro, Ana Filipa Mourão, Ana Maria Rodrigues, António Albino‐Teixeira, Fernando Pimentel-Santos, Filipa Oliveira‐Ramos, Helena Canhão, Joaquim Polido‐Pereira, João Eurico Fonseca, José António Pereira da Silva, José Carlos Romeu, José Melo Gomes, Lúcia Helena Rodrigues Costa, Luís Felipe G. da Graça, Maria Leandro, María José Santos, Pedro Machado, Sofía Ramiro,
Tópico(s): Medical and Biological Sciences
2018 - Sociedade Portuguesa de Reumatologia | Acta reumatológica portuguesa
Margarida Rodrigues Santos, Ana Rita Couto, I. Foroni, Bruno Filipe Bettencourt, Zhixiu Li, Raquel Meneses, Lawrie Wheeler, Joaquim Polido‐Pereira, Fernando Pimentel-Santos, João Eurico Fonseca, Helena Alves, António Martinho, Manuela Lima, Matthew A. Brown, Jácome Bruges‐Armas,
Objectives Ankylosing spondylitis (AS) is the most prevalent form of spondyloarthritis, with a known genetic association with the HLA-B27 molecule. The aim of this study was to assess the contribution of the HLA-G, HLA-E and HLA-F to AS susceptibility/protection in Portuguese patients with HLA-B27 AS and HLA-B27 unaffected controls. Methods High-resolution typing of HLA-G , HLA - E and HLA - F was performed in 228 patients with HLA-B27 AS and 244 HLA-B27 unaffected controls. Allelic, genotypic and haplotypic ...
Tópico(s): Systemic Lupus Erythematosus Research
2018 - BMJ | RMD Open
Santiago Rodrigues-Manica, Alexandre Sepriano, Sofía Ramiro, Fernando Pimentel-Santos, Polina Putrik, Elena Nikiphorou, Sam Norton, Anna Moltó, Maxime Dougados, Désirée van der Heijde, Robert Landewé, Filip Van den Bosch, Annelies Boonen,
Objectives To explore the role of individual and country level socioeconomic (SE) factors on employment, absenteeism and presenteeism in patients with spondyloarthritis (SpA) across 22 countries worldwide. Methods Patients with a clinical diagnosis of SpA fulfilling the ASAS classification criteria and in working age (≤65 years) from COMOSPA were included. Outcomes of interest were employment status, absenteeism and presenteeism, assessed by the Work Productivity and Activity Impairment Specific General ...
Tópico(s): Psoriasis: Treatment and Pathogenesis
2018 - BMJ | Annals of the Rheumatic Diseases
Uta Kiltz, Désirée van der Heijde, Annelies Boonen, Nurullah Akkoç, Wilson Bautista‐Molano, Rubén Burgos‐Vargas, James Cheng‐Chung Wei, Praveena Chiowchanwisawakit, Maxime Dougados, Mehmet Tuncay Duruöz, Bassel Elzorkany, I. Z. Gaydukova, Lianne S. Gensler, Michele Gilio, Simeon Grazio, Jieruo Gu, Robert D. Inman, Tae‐Jong Kim, Victoria Navarro‐Compán, Helena Marzo‐Ortega, Salih Özgöçmen, Fernando Pimentel-Santos, Michael Schirmer, Simon Stebbings, Filip Van den Bosch, Astrid van Tubergen, J. Braun,
To evaluate construct validity, interpretability, reliability and responsiveness as well as determination of cut-off points for good and poor health within the original English version and the 18 translations of the disease-specific Assessment of Spondyloarthritis international Society Health Index (ASAS HI) in 23 countries worldwide in patients with spondyloarthritis (SpA).A representative sample of patients with SpA fulfilling the ASAS classification criteria for axial (axSpA) or peripheral SpA was ...
Tópico(s): Rheumatoid Arthritis Research and Therapies
2018 - BMJ | Annals of the Rheumatic Diseases
Produção Nacional
Revisado por pares
Márcia Simone Almeida Galindo Do Carmo, Stênio Fernando Pimentel Duarte,
O uso de métodos contraceptivos tem aumentado, junto com a Contracepção de Emergência (CE). A anticoncepção de emergência é ofertada para mulheres em idade reprodutiva em situações de caráter excepcional. O uso da pílula do dia seguinte requer algumas precauções, com o intuito de garantir sua eficácia, dentre essas, destaca-se o intervalo de tempo da relação sexual e a sua administração. O uso rotineiro compromete sua eficácia. Com isso, o estudo tem o intuito de avaliar o conhecimento das usuárias ...
Tópico(s): Reproductive Health and Contraception
2017 - Persona Institute of Higher Education | ID on line REVISTA DE PSICOLOGIA
Produção Nacional
Revisado por pares
Perla F. Araújo, Adriana B. Almeida, Carlos Fernando Pimentel, Adriano R. Silva, Alessandro O. Sousa, Sebastião Aldo da Silva Valente, Vera Valente, Manuela M Britto, Ana C. Rosa, Rozeneide M. Alves, Luciana Hagström, Antonio RL Teixeira,
The Trypanosoma cruzi infection endemic in Latin America has now spread to several countries across four continents; this endemic involves triatomine vector-free protists. We hypothesised that the sexual transmission of T. cruzi contributes to the ongoing spread of Chagas disease.A short-term longitudinal study was conducted to evaluate this hypothesis.The study population comprised 109 subjects from four families, among whom 21 had been diagnosed with acute Chagas disease by direct parasitological ...
Tópico(s): Synthesis and Biological Evaluation
2017 - Instituto Oswaldo Cruz, Ministério da Saúde | Memórias do Instituto Oswaldo Cruz
Produção Nacional
Revisado por pares
Désirée van der Heijde, Sofía Ramiro, Robert Landewé, Xenofon Baraliakos, Filip Van den Bosch, Alexandre Sepriano, Andrea Regel, Adrian Ciurea, Hanne Dagfinrud, Maxime Dougados, F. van Gaalen, Pál Géher, Irene van der Horst‐Bruinsma, Robert D. Inman, Merryn Jongkees, Uta Kiltz, Tore K Kvien, Pedro Machado, Helena Marzo‐Ortega, Anna Moltó, Victoria Navarro‐Compán, Salih Özgöçmen, Fernando Pimentel-Santos, John D. Reveille, Martín Rudwaleit, Jochen Sieper, Percival D. Sampaio‐Barros, Dieter Wiek, J. Braun,
To update and integrate the recommendations for ankylosing spondylitis and the recommendations for the use of tumour necrosis factor inhibitors (TNFi) in axial spondyloarthritis (axSpA) into one set applicable to the full spectrum of patients with axSpA. Following the latest version of the European League Against Rheumatism (EULAR) Standardised Operating Procedures, two systematic literature reviews first collected the evidence regarding all treatment options (pharmacological and non-pharmacological) ...
Tópico(s): Rheumatoid Arthritis Research and Therapies
2017 - BMJ | Annals of the Rheumatic Diseases
Nicolás Quezada, Rodrigo Muñoz, Carla Morelli, Dannae Turiel, Julián Hernández, Fernando Pimentel, Alex Escalona,
Tópico(s): Gastroesophageal reflux and treatments
2017 - Springer Science+Business Media | Surgical Endoscopy