Lennard L. Bohlender, Juliana Parsons, Sebastian N. W. Hoernstein, Nina Bangert, Fernando Rodríguez-Jahnke, Ralf Reski, Eva L. Decker,
As biopharmaceuticals, recombinant proteins have become indispensable tools in medicine. An increasing demand, not only in quantity but also in diversity, drives the constant development and improvement of production platforms. The N-glycosylation pattern on biopharmaceuticals plays an important role in activity, serum half-life and immunogenicity. Therefore, production platforms with tailored protein N-glycosylation are of great interest. Plant-based systems have already demonstrated their potential ...
Tópico(s): Toxin Mechanisms and Immunotoxins
2022 - Frontiers Media | Frontiers in Bioengineering and Biotechnology
Lennard L. Bohlender, Juliana Parsons, Sebastian N. W. Hoernstein, Christine Rempfer, Natalia Ruiz-Molina, Timo Lorenz, Fernando Rodríguez Jahnke, Rudolf Figl, Benjamin Fode, Friedrich Altmann, Ralf Reski, Eva L. Decker,
Recombinantly produced proteins are indispensable tools for medical applications. Since the majority of them are glycoproteins, their N -glycosylation profiles are major determinants for their activity, structural properties and safety. For therapeutical applications, a glycosylation pattern adapted to product and treatment requirements is advantageous. Physcomitrium patens (Physcomitrella, moss) is able to perform highly homogeneous complex-type N -glycosylation. Additionally, it has been glyco-engineered ...
Tópico(s): Viral Infectious Diseases and Gene Expression in Insects
2020 - Frontiers Media | Frontiers in Plant Science
Konrad Müller, David Siegel, Fernando Rodríguez Jahnke, Katrin Gerrer, Sabrina Wend, Eva L. Decker, Ralf Reski, Wilfried Weber, Matías D. Zurbriggen,
On command control of gene expression in time and space is required for the comprehensive analysis of key plant cellular processes. Even though some chemical inducible systems showing satisfactory induction features have been developed, they are inherently limited in terms of spatiotemporal resolution and may be associated with toxic effects. We describe here the first synthetic light-inducible system for the targeted control of gene expression in plants. For this purpose, we applied an interdisciplinary ...
Tópico(s): CRISPR and Genetic Engineering
2014 - Royal Society of Chemistry | Molecular BioSystems
Rhaishudin Jafar Rumandan, Margareth Sylvia, Reski Putra Utama,
Tópico(s): Regional Development and Policy
2024 - Taylor & Francis | European Planning Studies