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Artigo Acesso aberto Revisado por pares

Graeme J. Hankey, João Costa, José M. Ferro, Jordi A. Matías‐Guiu, José Álvarez‐Sabín, Ferrán Torres,

... MD, PhD, José Alvarez-Sabin, MD, PhD and Ferran Torres, PhD Graeme J. HankeyGraeme J. Hankey From the ... Clinical Trials Unit, Hospital Clínic Barcelona, Spain. and Ferran TorresFerran Torres From the Neurology Department (J.C.), Santa Maria ...

Tópico(s): Stroke Rehabilitation and Recovery

2006 - Lippincott Williams & Wilkins | Stroke

Artigo

Helen Kovari, Caroline Sabin, Bruno Ledergerber, Lene Ryom, Peter Reiss, Matthew Law, Christian Pradier, François Dabis, Antonella d’Arminio Monforte, Colette Smith, Stéphane De Wit, Ole Kirk, Jens Lundgren, Rainer Weber, William G. Powderly, N. Shortman, Christiane Moecklinghoff, G. Reilly, Xavier Franquet, Camilla I. Hatleberg, Lene Ryom, Caroline Sabin, Daniella Kamara, Colette Smith, A. Phillips, Amanda Mocroft, Anders Bojesen, Jens Nielsen, Charles E. Matthews, David Raben, Jens Lundgren, Rikke Salbøl Brandt, Martin Rickenbach, Iuri Fanti, Eric Krum, M Hillebregt, S. Geffard, Jaohar Mourabi, Anders Sundström, M Delforge, Éric Fontas, Ferrán Torres, Hamish McManus, Seth Wright, Jesper Kjær, Anette Sjøl, P. Meidahl, J. Helweg-Larsen, Johan Iversen, Lene Ryom, Amanda Mocroft, Ole Kirk, Peter Reiss, Michael J. Ross, Christoph A. Fux, P. Morlat, Olivier Moranne, Anouk M Kesselring, David A Kamara, Colette Smith, Jens Lundgren, Colette Smith, Lene Ryom, A. Phillips, Rainer Weber, P. Morlat, Christian Pradier, Peter Reiss, Nina Friis‐Møller, Justyna D. Kowalska, Jens Lundgren, Caroline Sabin, Matthew Law, Antonella d’Arminio Monforte, François Dabis, Mathias Bruyand, Peter Reiss, Colette Smith, David A Kamara, Mark Bower, Gerd Fätkenheuer, Andrew E. Grulich, Lene Ryom, Jens Lundgren, Peter Reiss, S Zaheri, M Hillebregt, Luuk Gras, Jan M. Prins, Taco W. Kuijpers, H. J. Scherpbier, Jan T. M. van der Meer, F.W.M.N. Wit, Mieke H. Godfried, Peter Reiss, T. van der Poll, F.J.B. Nellen, J Lange, Suzanne E. Geerlings, M. van Vugt, Dasja Pajkrt, J. C. Bos, Marc van der Valk, Marlous L. Grijsen, W. Joost Wiersinga, Abraham Goorhuis, Joppe W. Hovius, S.H. Lowe, Astrid Oude Lashof, Dirk Posthouwer, M.J.H. Pronk, Heidi S. M. Ammerlaan, M.E. van der Ende, T.E.M.S. de Vries-Sluijs, Carolina A. M. Schurink, Jan Nouwen, Annelies Verbon, Bart Rijnders, Eric C. M. Van Gorp, M. van der Feltz, Gertjan J. A. Driessen, Annemarie M. C. van Rossum, Judith Branger, Emile F. Schippers, Cees van Nieuwkoop, E. P. van Elzakker, P. H. P. Groeneveld, J.W. Bouwhuis, Robert Soetekouw, Reinier W. ten Kate, Frank P. Kroon, Jaap T. van Dissel, Sandra M. Arend, Mark de Boer, H. Jolink, Hans Vollaard, Martijn P. Bauer, Jan G. den Hollander, Katalin Pogány, G. van Twillert, W. Kortmann, J. W. T. Cohen Stuart, B. M. W. Diederen, Eliane M.S. Leyten, L. B. S. Gelinck, G. J. Kootstra, Corine E. Delsing, K. Brinkman, Willem L. Blok, P. H. J. Frissen, W.E.M. Schouten, G.E.L. van den Berk, M.E.E. van Kasteren, A.E. Brouwer, Jan A. Veenstra, Kamilla D. Lettinga, Jan W. Mulder, S.M.E. Vrouenraets, Fanny N. Lauw, Arne van Eeden, D. W. M. Verhagen, Herman G. Sprenger, R. A. Doedens, Elisabeth H. Schölvinck, Sander van Assen, Wouter F.W. Bierman, P.P. Koopmans, Monique Keuter, André van der Ven, H.J.M. ter Hofstede, A. S. M. Dofferhoff, Adilia Warris, Reinout van Crevel, A. I. M. Hoepelman, Tania Mudrikova, Michael Schneider, Pauline M. Ellerbroek, Jan Jelrik Oosterheert, J.E. Arends, M.W.M. Wassenberg, Roos E. Barth, Michiel A. van Agtmael, R.M. Perenboom, Frans A.P. Claessen, Marije K. Bomers, Edgar J.G. Peters, Sibyl P. M. Geelen, Tom F.W. Wolfs, Louis Bont, Claudia Richter, J.P. van der Berg, Elisabeth H. Gisolf, Maarten van den Berge, Arjan Stegeman, Marit G. A. van Vonderen, D P F van Houte, Sebastiaan Weijer, Rachida el Moussaoui, Chris Winkel, Faj Muskiet, Robin M. Voigt, Fidéline Bonnet-Serrano, François Dabis, Fidéline Bonnet-Serrano, S. Bouchet, Dominique Breilh, Geneviève Chêne, François Dabis, M. Dupon, H. Fleury, Valérie Gaborieau, D. Lacoste, Denis Malvy, P. Mercié, P. Morlat, D. Neau, Isabelle Pellegrin, JL Pellegrin, Sandrine Reigadas, S. Tchamgoué, Mathias Bruyand, Geneviève Chêne, François Dabis, Catherine Fagard, S. Lawson‐Ayayi, Laura Richert, Rodolphe Thiébaut, L. Wittkop, Keila Magalhães André, Fidéline Bonnet-Serrano, N. Bernard, L. Caunègre, C. Cazanave, J. Ceccaldi, I. Chossat, C Courtault, F. Dauchy, S Witte, D. Dondia, M. Dupon, A. Dupont, P. Duffau, H. Dutronc, Sophie Farbos, I. Faure, Valérie Gaborieau, Y Gérard, C. Greib, M. Hessamfar-Joseph, Yoannis Imbert, D. Lacoste, P. Lataste, Estibaliz Lazaro, Denis Malvy, J. Marie, M. Méchain, JP. Meraud, P. Mercié, É. Monlun, P. Morlat, D. Neau, Anthony Ochoa, JL Pellegrin, M. Pillot-Debelleix, Thierry Pistone, Iona Raymond, M. C. Receveur, P Rispal, L. Sorin, S. Tchamgoué, C Valette, M.A. Vandenhende, MO. Vareil, Jean‐François Viallard, H. Wille, Grégory J. Wirth, J.F. Moreau, Isabelle Pellegrin, H. Fleury, M.E. Lafon, Sandrine Reigadas, Pascale Trimoulet, S. Bouchet, Dominique Breilh, Françoise Haramburu, G. Miremont-Salamé, M.J. Blaizeau, I. Crespel, M. Decoin, Sandrine Delveaux, F. Diarra, C d'Ivernois, C. Hanappier, D. Lacoste, S. Lawson‐Ayayi, Olivier Leleux,

Abstract Background. Although human immunodeficiency virus (HIV)-positive persons on antiretroviral therapy (ART) frequently have chronic liver enzyme elevation (cLEE), the underlying cause is often unclear. Methods. Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) Study participants without chronic viral hepatitis were observed to the earliest of cLEE (elevated aminotransferase ≥6 months), death, last follow-up, or January 2, 2014. Antiretroviral treatment exposure was categorized as follows: ...

Oxford University Press

Artigo Revisado por pares

Xavier Muñoz, Sara Sánchez‐Vidaurre, Oriol Roca, Ferrán Torres, Ferrán Morell, María Jesús Cruz,

Summary Background Little research has been devoted to the characteristics of bronchial inflammation in patients with stable, well controlled asthma. Objective The aim of this study was to assess the degree and type of airway inflammation and to investigate the relationship between inflammation and bronchial hyperresponsiveness in patients with well controlled asthma. Methods A cross‐sectional study was conducted in 84 adult patients (43 men, mean age 43 years) with documented well controlled asthma. ...

Tópico(s): IL-33, ST2, and ILC Pathways

2012 - Wiley | Clinical & Experimental Allergy

Artigo Acesso aberto Revisado por pares

Xavier Muñoz, Mónica Sánchez-Ortíz, Ferràn Torres, Ana Villar, Ferrán Morell, María Jesús Cruz,

Reliable methods are needed to diagnose hypersensitivity pneumonitis. The aim of the study was to establish the diagnostic yield of specific inhalation challenge (SIC) in patients with hypersensitivity pneumonitis. All patients with suspected hypersensitivity pneumonitis in whom SIC was performed (n=113) were included. SIC was considered positive when patients showed a decrease of >15% in forced vital capacity (FVC) or >20% in diffusing capacity of the lung for carbon dioxide, or a decrease of 10% to ...

Tópico(s): Respiratory and Cough-Related Research

2014 - European Respiratory Society | European Respiratory Journal

Artigo Revisado por pares

Joan Ramón Masclans, Oriol Roca, Xavier Muñoz, Esther Pallisa, Ferràn Torres, Jordi Rello, Ferrán Morell,

ARDS can produce a loss of lung function with persistent sequelae. This study aimed to evaluate health-related quality of life (HRQL) in survivors of ARDS compared with a healthy reference population and to determine the middle/long-term radiographic abnormalities and functional status, as well as their relation to observed HRQL, in these patients.This was a prospective study carried out in three ICUs. HRQL in patients was determined with the Nottingham Health Profile immediately after ARDS diagnosis ...

Tópico(s): Chronic Obstructive Pulmonary Disease (COPD) Research

2011 - Elsevier BV | CHEST Journal

Artigo Acesso aberto Revisado por pares

Xavier Muñoz, Astrid Crespo‐Lessmann, Sergi Martí, Ferrán Torres, Jaume Ferrer, Ferrán Morell,

Two modes of noninvasive home mechanical ventilation (NIHMV) with volumetric ventilators were compared in patients with chronic respiratory failure.Retrospective, parallel-group, comparative study.Third-level teaching Hospital in Barcelona (Spain).We studied 110 patients with chronic hypercapnic respiratory failure secondary to neuromuscular disease, kyphoscoliosis or post-tuberculosis sequelae, starting NIHMV with volumetric ventilators. The assist/control (A/C) ventilation mode was used in 45 patients ...

Tópico(s): Cystic Fibrosis Research Advances

2005 - Elsevier BV | Respiratory Medicine

Artigo Acesso aberto Revisado por pares

Xavier Muñoz, María Jesús Cruz, Ramón Orriols, Ferrán Torres, Meritxell Espuga, Ferrán Morell,

Background: The significant value of tests used to certify the diagnosis of occupational asthma due to persulphate salts remains uncertain. Aims: To validate the specific inhalation challenge (SIC) test for the diagnosis of occupational asthma. Methods: Eight patients with occupational asthma due to persulphate salts, eight patients with bronchial asthma who were never exposed to persulphate salts, and ten healthy subjects were studied. Clinical history taking, spirometry, bronchial challenge with ...

Tópico(s): Air Quality and Health Impacts

2004 - BMJ | Occupational and Environmental Medicine

Artigo Revisado por pares

Mónica Guevara, María E. Baccaro, Aldo Torre, Beatriz Gómez‐Ansón, José Ríos, Ferrán Torres, Lorena Rami, Gemma C. Monté, Marta Martín–Llahí, Vicente Arroyo, Pere Ginès,

The aim of this study was to investigate whether hyponatremia is a risk factor of overt hepatic encephalopathy (HE) in cirrhosis.A total of 61 patients with cirrhosis were evaluated prospectively for 1 year and all episodes of overt HE were recorded. Predictive factors of HE were analyzed using a conditional model (Prentice, Williams, and Peterson) for recurrent events to assess the relationship between HE and time-dependent covariates. The effects of hyponatremia on the brain concentration of organic ...

Tópico(s): Liver Disease Diagnosis and Treatment

2009 - Lippincott Williams & Wilkins | The American Journal of Gastroenterology

Artigo Acesso aberto Revisado por pares

Sergi Martí, Gabriel Sampol, Xavier Muñoz, Ferràn Torres, A. Planas Roca, Patrícia Lloberes, T. Sagalés, Pedro Quesada, Ferrán Morell,

The aim of this study was to determine mortality in patients with sleep apnoea/hypopnoea syndrome (SAHS) according to the treatments employed and comorbidity. An historical cohort of patients with SAHS diagnosed at a university hospital between 1982 and 1992 and followed until 1996 was studied. From a total of 475 SAHS patients, 444 (94%), with a mean+/-SD apnoea/hypopnoea index at diagnosis of 55+/-27, were located and included in the study. SAHS treatments employed were: surgery (88), weight loss ( ...

Tópico(s): Neuroscience of respiration and sleep

2002 - European Respiratory Society | European Respiratory Journal

Artigo Acesso aberto Revisado por pares

Wolfgang Kuchinke, Christian Ohmann, Qin Yang, Nader Salas, Jens Lauritsen, François Gueyffier, Alan Leizorovicz, Carmen Schade‐Brittinger, Michael Wittenberg, Zoltán Vokó, Siobhan Gaynor, Margaret Cooney, Peter Doran, Aldo P. Maggioni, Andrea Lorimer, Ferràn Torres, Gladys McPherson, Jim Charwill, Mats Hellström, Stéphane Lejeune,

The use of Clinical Data Management Systems (CDMS) has become essential in clinical trials to handle the increasing amount of data that must be collected and analyzed. With a CDMS trial data are captured at investigator sites with "electronic Case Report Forms". Although more and more of these electronic data management systems are used in academic research centres an overview of CDMS products and of available data management and quality management resources for academic clinical trials in Europe ...

Tópico(s): Ethics in Clinical Research

2010 - Springer Science+Business Media | Trials

Artigo Revisado por pares

G. Cabrera, Ferrán Torres, J.C. Caicedo, W. Aperador, C. Amaya, P. Prieto,

Tópico(s): Semiconductor materials and devices

2010 - Springer Science+Business Media | Journal of Materials Engineering and Performance

Artigo Revisado por pares

Rosa Solà, Éric Bruckert, Rosa M. Valls, Silvia Narejos, Xavier Luque, Manuel Castro-Cabezas, Gema Doménech, Ferràn Torres, Mercedes Heras, Xavier Farrés, José-Vicente Vaquer, J Fausto Bustamante Martínez, Mari Cruz Almaraz, Anna Anguera,

Abstract The objective was to evaluate whether the soluble fibre Plantago ovata (Po)-husk improves cardiovascular disease (CVD) risk biomarkers including low-density lipoprotein cholesterol (LDL-C). Methods In a multi-centred, double-blind, placebo-controlled, parallel, randomised trial conducted in primary care-clinics in Spain, France and Holland, mild-moderate hypercholesterolaemic patients (age range: 43–67 years) received 14g/d of Po-husk ( n =126) or placebo (microcrystalline-cellulose 14g/d; n =128) in a ...

Tópico(s): Ginkgo biloba and Cashew Applications

2010 - Elsevier BV | Atherosclerosis

Artigo Acesso aberto Revisado por pares

Sergio Amaro, Xabier Urra, Manuel Gómez‐Choco, Vı́ctor Obach, Álvaro Cervera, Martha Vargas, Ferrán Torres, José Ríos, Anna M. Planas, Ángel Chamorro,

Uric acid (UA) is a neuroprotective antioxidant that improves the benefits of alteplase in experimental ischemia. However, it is unknown whether endogenous UA also influences the response to thrombolysis in patients with stroke.A total of 317 consecutive patients treated with thrombolysis were included in a prospective stroke registry. Demographics, laboratory data, neurological course, and infarction volume were prospectively collected. Excellent outcome was defined as achieving a modified Rankin ...

Tópico(s): Bone and Joint Diseases

2010 - Lippincott Williams & Wilkins | Stroke

Artigo Acesso aberto Revisado por pares

Ronald J. Oudiz, Nazzareno Galiè, Horst Olschewski, Ferràn Torres, Adaani Frost, Hossein A. Ghofrani, David B. Badesch, Michael D. McGoon, Vallerie V. McLaughlin, Ellen B. Roecker, Brooke C. Harrison, Darrin Despain, Christopher Dufton, Lewis J. Rubin,

This study evaluated the safety and efficacy of ambrisentan for a period of 2 years in patients with pulmonary arterial hypertension (PAH). Ambrisentan is an oral, once-daily endothelin receptor antagonist that is selective for the endothelin type A receptor. The ARIES-1 (Ambrisentan in Pulmonary Arterial Hypertension, Randomized, Double-Blind, Placebo-Controlled, Multicenter, Efficacy Studies) and ARIES-2 trials were the pivotal 12-week, placebo-controlled studies that led to the regulatory approval ...

Tópico(s): Cardiac tumors and thrombi

2009 - Elsevier BV | Journal of the American College of Cardiology

Artigo Revisado por pares

Cristina Vilaplana, Eva Montané, Sergio Pinto, Ana María Barriocanal, Gema Doménech, Ferràn Torres, Pere‐Joan Cardona, Joan Costa‐Font,

A Phase I interventional Clinical Trial was performed with a potential tuberculosis vaccine, based on detoxified cellular fragments of M. tuberculosis, named RUTI®. The objective was to evaluate the safety profile and T-cell immune responses over a 6-month period following subcutaneous inoculation. The double-blind, randomized and placebo-controlled trial was conducted in healthy volunteers, all recruited at one site. RUTI®, at each of the four tested doses, starting from 5 μg and going up to 200 ...

Tópico(s): Mycobacterium research and diagnosis

2009 - Elsevier BV | Vaccine

Artigo Acesso aberto Revisado por pares

Andrea De Gottardi, Thierry Thévenot, Laurent Spahr, Isabelle Morard, Solange Bresson‐Hadni, Ferrán Torres, Emiliano Giostra, Antoine Hadengue,

Complications and technical problems of paracentesis in cirrhotic patients are infrequent. However, the severity and the incidence of these events and their risk factors have not been assessed prospectively.Cirrhotic patients (n = 171) undergoing paracentesis were included. Of the 515 paracenteses, 8.8% were diagnostic, and 91.2% were therapeutic. Technical features, demographic data, and adverse events during a period of 72 hours after the procedure were examined.Major complications occurred in 1. ...

Tópico(s): Organ Transplantation Techniques and Outcomes

2009 - Elsevier BV | Clinical Gastroenterology and Hepatology

Revisão Acesso aberto Revisado por pares

Núria Cruz, José Sánchez‐Moreno, Ferràn Torres, José Manuel Goikolea, Marc Valentí, Eduard Vieta,

Randomized, controlled trials have demonstrated efficacy for second-generation antipsychotics in the treatment of acute mania in bipolar disorder. Despite depression being considered the hallmark of bipolar disorder, there are no published systematic reviews or meta-analyses to evaluate the efficacy of modern atypical antipsychotics in bipolar depression. We systematically reviewed published or registered randomized, double-blind, placebo-controlled trials (RCTs) of modern antipsychotics in adult ...

Tópico(s): Schizophrenia research and treatment

2009 - University of Oxford | The International Journal of Neuropsychopharmacology

Artigo Acesso aberto Revisado por pares

Andrea De Gottardi, Thierry Thévenot, Laurent Spahr, Isabelle Morard, Solange Bresson‐Hadni, Ferrán Torres, Emile Giostra, A. Hadengue,

Results: It was seen that a healthy person scored between 0-20, a person with overt encephalopathy 41-60 and 21-40 meant minimal hepatic encephalopathy.Cut-off for each domain was also proposed separately.Conclusion: Apart from being highly specific and sensitive, the proposed test (which is in the form of a colorful game) seems to be amusing for the depressed cirrhotic.

Tópico(s): Liver Disease and Transplantation

2009 - Elsevier BV | Journal of Hepatology

Artigo Acesso aberto Revisado por pares

Susana Monzón, Elena Arrondo, Joan Bartra, Ferràn Torres, María Basagaña, Maria del Mar San Miguel, Rosario Alonso, Anna Cisteró‐Bahíma,

Total tear IgE has been considered to play an important role in allergic conjunctivitis, and measurement has been considered useful for diagnosis. The aim of this study was to ascertain whether Lacrytest(®), a new commercialised method to detect IgE levels in lacrimal fluid, could constitute a screening test for the diagnosis of allergic conjunctivitis. This was a cross-sectional study. Patients with seasonal and perennial allergic conjunctivitis, vernal keratoconjunctivitis and a control group ...

Tópico(s): Nasolacrimal Duct Obstruction Treatments

2009 - Hindawi Publishing Corporation | Journal of Allergy

Artigo Acesso aberto Revisado por pares

J.A. Carrión, Ferrán Torres, Gonzalo Crespo, Rosa Miquel, Juan‐Carlos García‐Valdecasas, Miquel Navasa, Xavier Forns,

Significant liver fibrosis (F ≥ 2) and portal hypertension (hepatic venous pressure gradient [HVPG] ≥ 6 mmHg) at 1 year after liver transplantation (LT) identify patients with severe hepatitis C recurrence. We evaluated whether repeated liver stiffness measurements (LSM) following LT can discriminate between slow and rapid “fibrosers” (fibrosis stage F2-F4 at 1 year after LT). Eighty-four patients who had undergone LT and who were infected with hepatitis C virus (HCV) and 19 LT controls who were not infected ...

Tópico(s): Liver Disease and Transplantation

2009 - Lippincott Williams & Wilkins | Hepatology

Artigo Acesso aberto Revisado por pares

Verónica Rodilla, Alberto Villanueva, Antònia Obrador‐Hevia, Alexandre Robert‐Moreno, Vanesa Fernández‐Majada, Andrea Grilli, Núria López-Bigas, Nicolás Bellora, M. Mar Albà, Ferrán Torres, Mireia Duñach, Xavier Sanjuán, Sara González, Thomas Gridley, Gabriel Capellà, Anna Bigas, Lluı́s Espinosa,

Notch has been linked to beta-catenin-dependent tumorigenesis; however, the mechanisms leading to Notch activation and the contribution of the Notch pathway to colorectal cancer is not yet understood. By microarray analysis, we have identified a group of genes downstream of Wnt/beta-catenin (down-regulated when blocking Wnt/beta-catenin) that are directly regulated by Notch (repressed by gamma-secretase inhibitors and up-regulated by active Notch1 in the absence of beta-catenin signaling). We demonstrate ...

Tópico(s): Genetic factors in colorectal cancer

2009 - National Academy of Sciences | Proceedings of the National Academy of Sciences

Artigo Acesso aberto Revisado por pares

Shannon Blalock, Susan Matulevicius, Laura C. Mitchell, Sharon C. Reimold, John J. Warner, Ronald M. Peshock, Ferrán Torres, Kelly Chin,

This study evaluated long-term outcomes in patients with pulmonary arterial hypertension (PAH) undergoing treatment with ambrisentan monotherapy, a selective oral endothelin-1 receptor antagonist.Patients who participated in the Ambrisentan in Pulmonary Arterial Hypertension: A Phase 3, Randomized, Double-Blind, Placebo-Controlled Multicenter Efficacy Study (ARIES-1) clinical trial and extension phase at our institution were included. Cardiac catheterization, 6-minute walk distance (6MWD), and cardiac ...

Tópico(s): Vascular Anomalies and Treatments

2009 - Elsevier BV | Journal of Cardiac Failure

Artigo Revisado por pares

Xavier Carné, José Ríos, Ferràn Torres,

Recently, new concerns on the safety profile of nonsteroidal anti-inflammatory drugs (NSAIDs) have been raised by the European Medicines Agency (EMEA) and other regulatory authorities. The safety profile of oral dexketoprofen trometamol for the treatment of acute mild to moderate pain of different causes in actual conditions of use in the primary care setting was assessed. A prospective cohort study was designed to evaluate the tolerability of dexketoprofen compared with other commonly prescribed ...

Tópico(s): Asthma and respiratory diseases

2009 - Thomson Reuters | Methods and Findings in Experimental and Clinical Pharmacology

Revisão Revisado por pares

Martha Kingman, Rosechelle Ruggiero, Ferràn Torres,

Pulmonary arterial hypertension (PAH) is a disease of the pulmonary vasculature characterized by vasoconstriction and vascular proliferation, which leads to right heart failure and death. Prostacyclin, NO and endothelin are felt to be key mediators in the development of PAH. We present the available published and presented data about ambrisentan, an ETA-selective endothelin receptor antagonist (ERA) and newest ERA agent to be approved by the FDA for the treatment of PAH in patients with WHO functional ...

Tópico(s): Renin-Angiotensin System Studies

2009 - Taylor & Francis | Expert Opinion on Pharmacotherapy

Artigo Acesso aberto Revisado por pares

Peré Domingo, Ignacio Suárez-Lozano, Ferrán Torres, Virginia Pomar, Esteban Ribera, Ma José Galindo, J. Cosin, Ma Luisa Garcia-Alcalde, Francesc Vidal, José López‐Aldeguer, Bernardino Roca, J Díaz González, Fernando Lozano, Myriam Garrido,

The burden that spontaneous bacterial meningitis (SBM) currently represents among HIV-1-infected patients is poorly known.We prospectively evaluated 32 episodes of SBM in HIV-1-infected patients from the VACH (VIH-Aplicación de Control Hospitalario) Cohort and compared findings with those of 267 episodes in uninfected persons, matched by age and year of infection. A group of 13,187 HIV-1-infected patients from the VACH Cohort were used to identify predictors for acquiring SBM.Between 1997 and 2006, ...

Tópico(s): Pneumocystis jirovecii pneumonia detection and treatment

2009 - Lippincott Williams & Wilkins | JAIDS Journal of Acquired Immune Deficiency Syndromes

Artigo

Teresa Gómez‐Isla, Rafael Blesa, Merçé Boada, Jordi Clarimón, Teodoro del Ser, Gemma Domènech, José M. Ferro, Beatriz Gómez‐Ansón, J.M. Manubens, J. M. Martínez‐Lage, David G. Muñoz, Jordi Peña‐Casanova, Ferràn Torres,

Background Amnestic mild cognitive impairment represents, in many cases, the earliest clinical phases of Alzheimer disease. Anti-inflammatory agents have epidemiologic support as drugs potentially beneficial in Alzheimer disease. In vivo studies have shown that Triflusal and its active metabolite 2-hydroxy-4-trifluoromethyl-benzoic acid have potent anti-inflammatory actions in the central nervous system. Methods We conducted a randomized, double-blind, placebo-controlled trial of Triflusal in patients ...

Tópico(s): Neurological Disorders and Treatments

2008 - Lippincott Williams & Wilkins | Alzheimer Disease & Associated Disorders

Artigo Revisado por pares

M. C. Atienzar, José M. Palanca, Ferràn Torres, R. Borràs, Seon-Hee Gil, I. Esteve,

Tópico(s): Cardiac, Anesthesia and Surgical Outcomes

2008 - Elsevier BV | International Journal of Obstetric Anesthesia

Artigo Revisado por pares

Kelly Chin, Martha Kingman, James A. de Lemos, John J. Warner, Sharon C. Reimold, Ronald M. Peshock, Ferràn Torres,

Patients with pulmonary arterial hypertension (PAH) usually show improvements in symptoms, exercise capacity, and hemodynamics after treatment with approved medical therapies. This study sought to determine whether improvement in right-sided cardiac function measured using cardiac magnetic resonance imaging would also be seen and whether these changes would correlate with improvement in exercise capacity. Sixteen patients with PAH underwent evaluation at baseline and after 12 months of treatment ...

Tópico(s): Cardiovascular Issues in Pregnancy

2008 - Elsevier BV | The American Journal of Cardiology

Artigo Acesso aberto Revisado por pares

Peré Domingo, Ignacio Suárez-Lozano, Ferràn Torres, Ramón Teira, José López‐Aldeguer, Francesc Vidal, Agustín Matías Muñoz, Pompeyo Viciana, Francisco Lozano, A. Vergara, Bernardino Roca, María Luisa García Alcalde, Jaime Cosín, Alberto Terrón, MJ Galindo, Paloma Geijo, Esteban Ribera, J.J. González, T Sánchez, Juan Ramón Lacalle-Remigio, Myriam Garrido,

Efavirenz and lopinavir/ritonavir are both recommended antiretroviral agents for combination first-line therapy, although information on direct comparisons between them is scarce. A retrospective longitudinal study from the VACH cohort comparing both regimens was performed. Efficacy was examined comparing time to virological failure, CD4 recovery and clinical progression. Tolerability was examined comparing time to treatment discontinuation for any reason and for toxicity. Survival analysis was ...

Tópico(s): HIV/AIDS Research and Interventions

2008 - Oxford University Press | Journal of Antimicrobial Chemotherapy