Ferruccio Palazzesi, Alfonso Pozzan,
In the latest years, the application of deep generative models to suggest virtual compounds is becoming a new and powerful tool in drug discovery projects. The idea behind this review is to offer an updated view on de novo design approaches based on artificial intelligent (AI) algorithms, with a particular focus on ligand-based methods. We start this review by reporting a brief overview of the most relevant de novo design approaches developed before the use of AI techniques. We then describe the ...
Tópico(s): Protein Structure and Dynamics
2021 - Springer Science+Business Media | Methods in molecular biology
... and hyperactivate the p42/44 MAP kinase cascade Ferruccio Galbiati Ferruccio Galbiati The Albert Einstein Cancer Center, 1300 Morris ... USA Search for more papers by this author Ferruccio Galbiati Ferruccio Galbiati The Albert Einstein Cancer Center, 1300 Morris ... for more papers by this author Author Information Ferruccio Galbiati1,2, Daniela Volonté1,2, Jeffrey A. Engelman1, ... in soft agar and resulted in the de novo formation of caveolae (Engelman et al., 1997). Thus, ...
Tópico(s): Protein Kinase Regulation and GTPase Signaling
1998 - Springer Nature | The EMBO Journal
Francesco Locatelli, Daniele Marcelli, Ferruccio Conte, Marco DʼAmico, Lucia Del Vecchio, Aurelio Limido, Fabio Malberti, Donatella Spotti,
... on survival and the risk of developing de novo CVD. Of the 4191 patients with end-stage ... the analysis of the risk of developing de novo CVD. HD and PD were compared by use ... patients included in the CVD analysis developed de novo CVD (128 on HD and 69 on PD). ... 79 to 1.06). The risk of de novo CVD did not differ significantly by treatment modality ( ... 1.43). The risk of mortality and de novo CVD for new patients with ESRD assigned to ...
Tópico(s): Chronic Kidney Disease and Diabetes
2001 - American Society of Nephrology | Journal of the American Society of Nephrology
Arcangelo Nocera, Enzo Andorno, Augusto Tagliamacco, Nicola Morelli, G Bottino, Ferruccio Ravazzoni, M Casaccia, S Barocci, S. Alice, Gregorio Santori, R. Ghirelli, Umberto Valente,
... HCC-negative patients who developed posttransplantation cancers de novo. Of 18 patients in group a, 11 received ... monotherapy; (3) 1 HCC recurrence and 1 de novo pancreatic adenocarcinoma were observed at 14 and 16 ...
Tópico(s): Organ Transplantation Techniques and Outcomes
2008 - Elsevier BV | Transplantation Proceedings
Isabella Parolini, Massimo Sargiacomo, Ferruccio Galbiati, Giovanni Rizzo, F Grignani, Jeffrey A. Engelman, Takashi Okamoto, Tsuneya Ikezu, Philipp E. Scherer, Rosalia Mora, Enrique Rodriguez‐Boulan, C Peschle, Michael P. Lisanti,
... K562 cells is sufficient to reconstitute the de novo formation of caveolae in these cells. In addition, ...
Tópico(s): Erythrocyte Function and Pathophysiology
1999 - Elsevier BV | Journal of Biological Chemistry
Francesco Locatelli, Daniele Marcelli, Ferruccio Conte, Lucia Del Vecchio, Aurelio Limido, Fabio Malberti, Donatella Spotti, S Sforzini, for the Registro Lombardo Dialisi e Trapianto,
... on dialysis treatment, the risk to develop de novo cardiovascular disease increases by 4% for each year ...
Tópico(s): Heart Failure Treatment and Management
2000 - Elsevier BV | Kidney International
Vincenzo Mazzaferro, Raffaele Romito, Marcello Schiavo, Luigi Mariani, Tiziana Camerini, Sherrie Bhoori, Lorenzo Capussotti, Fulvio Calise, R Pellicci, Giulio Belli, A. Tagger, Massimo Colombo, Ferruccio Bonino, Pietro Majno, Josep M. Llovet,
... or late (>2 years) as metastases or de novo tumors. Interferon (IFN) has the potential for chemoprevention ...
Tópico(s): Hepatitis B Virus Studies
2006 - Lippincott Williams & Wilkins | Hepatology
Matilde Marchi, Simonetta Lisi, Michele Curcio, Serena Barbuti, Paolo Piaggi, Giovanni Ceccarini, Monica Nannipieri, Marco Anselmino, Claudio Di Salvo, Paolo Vitti, Aldo Pinchera, Ferruccio Santini, Margherita Maffei,
... demonstrated that demethylation (by decitabine) increase or de novo activate leptin expression in primary fibroblasts and HeLa ...
Tópico(s): Adipokines, Inflammation, and Metabolic Diseases
2011 - Landes Bioscience | Epigenetics
Erica Cassani, Michela Barichella, Raffaella Cancello, Ferruccio Cavanna, Laura Iorio, Emanuele Cereda, Carlotta Bolliri, Paola Zampella Maria, Francesca Bianchi, Benvenuto Cestaro, Gianni Pezzoli,
... levodopa (PD) or on no pharmacological treatment (De Novo, DPD; N=34) and an age and gender- ...
Tópico(s): Child Nutrition and Feeding Issues
2015 - Elsevier BV | Parkinsonism & Related Disorders
Marco Magnoni, Martina Berteotti, Ferruccio Ceriotti, Vincenzo Mallia, Vittoria Vergani, Giovanni Peretto, Giulia Angeloni, Nicole Cristell, Attilio Maseri, Domenico Cianflone,
... p=0.0057) and in patients with de novo ACS (OR 3.2, 95%CI 1.5- ...
Tópico(s): Streptococcal Infections and Treatments
2017 - Elsevier BV | International Journal of Cardiology
Carel W. le Roux, Arne Astrup, Ken Fujioka, Frank L. Greenway, David Lau, Luc Van Gaal, Rafael Violante Ortíz, John Wilding, Trine Vang Skjøth, Linda Shapiro Manning, F. Xavier Pi‐Sunyer, A. Hamann, Alain Barakat, Matthias Blüher, Thomas Linn, Andrea Mölle, Alexander Segner, Petra Stübler, Regina Tosch-Sisting, Furio Pacini, Ferruccio Santini, Giulio Marchesini, Carlo Maria Rotella, Cecilia Invitti, Roberto Vettor, Silvio Buscemi, Pedro Mezquita Raya, Felipe Casanueva Freijoo, Ramón Gomis de Barbará, Raffaele Carraro, Enrique Romero Bobillo, Carmen de la Cuesta, Csaba Farsang, Albert Császár, Barbara Zahorska‐Markiewicz, Danuta Pupek-Musialik, Edward Franek, Lucyna Ostrowska, Magdalena Olszanecka‐Glinianowicz, Nebojša Lalić, Dragan Micić, Bernhard Ludvik, Bernhard Paulweber, Rudolf Prager, André Scheen, Luc Van Gaal, Arne Astrup, Kjeld Hermansen, Sten Madsbad, Aila Rissanen, Sakari Nieminen, Markku J. Savolainen, Michel Krempf, Monique Romon, M. Laville, Michel Marre, R Mira, Francis Finucane, Aletha Veenendaal, Frank van Berkum, Solrun Johannsson-Vidarsdóttir, Vivienne Van de Walle, Eelco W. Meesters, Jøran Hjelmesæth, Tor Ole Klemsdal, Bård Kulseng, Birgit Bach-Kliegel, Kurt Laederach, Lukas Villiger, Alain Golay, Stefan Bilz, Thozhukat Sathyapalan, Stephen C. Bain, Sudhesh Kumar, Carel Wynard Le Roux, Michael E. J. Lean, Barbara McGowan, Tariq Rehman, John Wilding, Gary Wittert, Ian Caterson, Joeseph Proietto, John Prins, Bruno Geloneze Neto, Jorge Luiz Gross, Antônio Roberto Chacra, Alfredo Halpern, Henrique Suplicy, Francis Chun Chung Chow, Hemant Thacker, Manoj Chadha, Hemaraj Chandalia, AG Unnikrishnan, Sanjay Kalra, Neeta Deshpande, Minakshi Shunmugavelu, Vaishali Deshmukh, Maximo Maislos, G. Lieberman, Ilan Shimon, Naftali Stern, Dan Nabriski, Eddy Karnieli, Naim Shehadeh, Guillermo González-Gálvez, María del Rosario Arechavaleta-Granell, R. Ortiz, Guadalupe Morales Franco, Irina Gurieva, Л. А. Суплотова, Е. А. Трошина, Ludmila Ruyatkina, Emma Anatolievna Voychik, S. Yu. Martsevich, M.A. Startseva Startseva, Mary Seeber, Aysha Badat, Graham Ellis, Yüksel Altuntaş, Serdar Güler, Ender Ülgen, Tuncay Delibaşı, Tony Chetty, Randy Hart, Jeannette Janzen, Isabelle Labonté, David Lau, Joanne Liutkus, Dennis D. O’Keefe, Raj Padwal, Thomas Ransom, Richard Tytus, S. John Weisnagel, Jay Adler, Keith Aqua, Stephen Aronoff, Gary Bedel, Thomas Blevins, Joe Blumenau, Andrew Brockmyre, Robert S. Call, Rafael Canadas, Louis Chaykin, Kenneth L. Cohen, Jeffrey Keith Conrow, Matthew Davis, H. Jackson Downey, S.R. Drosman, Steven Duckor, Hayley Farmer, James J. Farrell, Stephen Fehnel, Matthew Patrick Finneran, Ray Forbes, Alan D. Forker, Mark Fredrick, Ken Fujioka, S Geller, Santosh Gill, Linda A. Glaser, Susan Neims Greco, Frank L. Greenway, Wayne L. Harper, Lee Herman, J. Hoekstra, Richard Ingebretsen, Rodney Ison, Rajeev Jain, Roy A. Kaplan, S. Kaster, Gregory Haase, Boris Kerzner, Judith L. Kirstein, William Koltun, Diane Krieger, Cora E. Lewis, Robert D. Madder, Richard N Marple, Edward J McDermott, Curtis J. Mello, Alan B. Miller, Julie Mullen, John Nardandrea, Patrick M. O’Neil, F. Xavier Pi-Sunyer, Ronald M Pucillo, Chanhaeng Rhee, Scott Redrick, Aaron Pardini, Jeffrey Rothman, Domenica Rubino, Gladstone Sellers, Timothy R. Smith, William Byars, Joseph Soufer, Allen Sussman, Kyle Patrick, Erich Lloyd Schramm, Martin van Cleeff, Saul Reuel Berg, Holly R. Wyatt, James A. Simon,
... diabetes in individuals with obesity and prediabetes. Funding Novo Nordisk, Denmark.
Tópico(s): Metabolism, Diabetes, and Cancer
2017 - Elsevier BV | The Lancet
Elisabetta Degasperi, Riccardo Perbellini, Roberta D’Ambrosio, Sara Uceda Renteria, Ferruccio Ceriotti, Alberto Perego, Corinna Orsini, Marta Borghi, Massimo Iavarone, Mariangela Bruccoleri, Alessandro Rimondi, Annalisa De Silvestri, Angelo Sangiovanni, Pietro Lampertico,
... from baseline, 34 (8.5%) patients developed de novo HCC; median AFP 9 (2‐12 868) ng/ ...
Tópico(s): Hepatitis C virus research
2021 - Wiley | Alimentary Pharmacology & Therapeutics
William R. Pitt, Jonathan Bentley, Christophe Boldron, Lionel Colliandre, Carmen Esposito, Elizabeth H. Frush, J. Kopec, Stéphanie Labouille, Jérôme Meneyrol, D. Pardoe, Ferruccio Palazzesi, Alfonso Pozzan, Jacob M. Remington, René Rex, Michelle Southey, Sachin Vishwakarma, Paul Walker,
... Via Alessandro Fleming, 4, 37135 Verona, ItalyMore by Ferruccio PalazzesiAlfonso PozzanAlfonso PozzanMolecular Architects, Aptuit Srl, Via Alessandro ... review (27) identified over 100 deep learning de novo design methods published between 2017 and 2020. Since ... useful reference points. Computational PipelinesThe advent of de novo design methods, particularly deep generative AI methods, has ...
Tópico(s): Innovative Microfluidic and Catalytic Techniques Innovation
2025 - American Chemical Society | Journal of Medicinal Chemistry
Alice Dainelli, Mohammad Sadegh Shams Nosrati, Ferruccio Romano, Fabiana Vercellino, Maria Margherita Mancardi, Annalaura Torella, Vincenzo Nigro, Valeria Capra, Federico Zara, Marcello Scala,
Tópico(s): Genomics and Rare Diseases
2025 - Wiley | Molecular Genetics & Genomic Medicine
Ferruccio Romano, Mariateresa Falco, Gerarda Cappuccio, Nicola Brunetti‐Pierri, Fortunato Lonardo, Annalaura Torella, M. Cristina Digilio, Maria Lisa Dentici, Paolo Alfieri, Emanuele Agolini, Antonio Novelli, Livia Garavelli, Andrea Accogli, Pasquale Striano, Gioacchino Scarano, Vincenzo Nigro, Marcello Scala, Valeria Capra,
... led to the identification of five novel de novo pathogenic variants in AHDC1 . All variants were extremely ...
Tópico(s): Genomics and Chromatin Dynamics
2022 - Wiley | Birth Defects Research
Em seu novo trabalho, L’uomo e l’unico, Andolfi reúne textos de Feuerbach, Stirner, Hess e Marx sobre uma questão ...
Tópico(s): Walter Benjamin Studies Compilation
2021 - UNIVERSIDADE FEDERAL DO CEARÁ | Revista Dialectus - Revista de Filosofia
Elena Freri, Laura Canafoglia, Claudia Ciaccio, Davide Rossi Sebastiano, Davide Caputo, Roberta Solazzi, Francesca L. Sciacca, Maria Iascone, Ferruccio Panzica, Tiziana Granata, Silvana Franceschetti, Nardo Nardocci,
... variant: c.1492dup (p.Met498Asnfs*3), occurring de novo and classifiable as pathogenic, in agreement with American ...
Tópico(s): Glycogen Storage Diseases and Myoclonus
2024 - Wiley | Movement Disorders
Federica Ruscitti, Maria Cerminara, Maria Iascone, Laura Pezzoli, Giulia Rosti, Ferruccio Romano, Patrizia Ronchetto, Giuseppe Martucciello, Silvia Buratti, Francesca Buffelli, Renata Bocciardi, Aldamaria Puliti, Maria Teresa Divizia,
... return, intestinal malrotation) and carrying the heterozygous de novo c.868C > T (p.Arg290Trp) variant in PBX1. ...
Tópico(s): Genetic and Kidney Cyst Diseases
2022 - Wiley | Birth Defects Research
GIUSEPPE DANIELE, Angela Dardano, Duccio Volterrani, Annamaria Ciccarone, Laura Giusti, Gayanè Aghakhanyan, Giovanni Ceccarini, Ferruccio Santini, Carlo Moretto, Paola Binda, Claudia Lunghi, Maria Concetta Morrone, Stefano Del Prato,
... plc., Merck Sharp & Dohme Corp., Novartis Pharmaceuticals Corporation, Novo Nordisk A/S, Sanofi, Servier, Takeda Pharmaceutical Company ...
Tópico(s): Cerebrovascular and Carotid Artery Diseases
2019 - American Diabetes Association | Diabetes
Angela Dardano, GIUSEPPE DANIELE, Claudia Lunghi, Annamaria Ciccarone, Ferruccio Santini, Giovanni Ceccarini, Carlo Moretto, Giuseppe Penno, Roberto Miccoli, Maria Concetta Morrone, Stefano Del Prato,
... Therapeutics, Inc., Merck & Co., Inc., Novartis Pharmaceuticals Corporation, Novo Nordisk A/S, Servier, Sanofi, Takeda Pharmaceuticals U. ...
Tópico(s): Cardiovascular Disease and Adiposity
2018 - American Diabetes Association | Diabetes
GIUSEPPE DANIELE, Angela Dardano, Claudia Lunghi, Paola Binda, Annamaria Ciccarone, Ferruccio Santini, Giovanni Ceccarini, Laura Giusti, Rosario Bellini, Marta Seghieri, S Del Guerra, Carlo Moretto, Maria Concetta Morrone, Stefano Del Prato,
... Therapeutics, Inc., Merck & Co., Inc., Novartis Pharmaceuticals Corporation, Novo Nordisk A/S, Servier, Sanofi, Takeda Pharmaceuticals U. ...
Tópico(s): Pituitary Gland Disorders and Treatments
2018 - American Diabetes Association | Diabetes