Risto O. Juvonen, Filip Novák, Eleni Emmanouilidou, Seppo Auriola, Juri M. Timonen, Aki T. Heikkinen, Jenni Küblbeck, Moshe Finel, Hannu Raunio,
Scoparone, a major constituent of the Chinese herbal medicine Yin Chen Hao, expresses beneficial effects in experimental models of various diseases. The intrinsic doses and effects of scoparone are dependent on its metabolism, both in humans and animals. We evaluated in detail the metabolism of scoparone in human, mouse, rat, pig, dog, and rabbit liver microsomes in vitro and in humans in vivo. Oxidation of scoparone to isoscopoletin via 6-O-demethylation was the major metabolic pathway in liver ...
Tópico(s): Plant chemical constituents analysis
2019 - Thieme Medical Publishers (Germany) | Planta Medica
Ladislava Bartošová, Filip Novák, Markéta Bébarová, Marek Frydrych, V. Brunclík, Radka Opatřilová, J. Kolevská, Petr Mokrý, Péter Kollár, Věra Strnadová, Pavel Suchý,
The antiarrhythmic action of the newly developed compound 44Bu (an original compound that was synthesized at our Faculty of Pharmacy) was tested on a model of aconitine-induced arrhythmia and compared with the effect of lidocaine. Both tested substances were administered either as therapeutic or prophylactic agents. 44Bu was highly effective in reducing the occurrence of ventricular fibrillation from 94% to 8% by therapeutic administration, and to 0% by prophylactic administration. The overall mortality ...
Tópico(s): Poisoning and overdose treatments
2007 - Elsevier BV | European Journal of Pharmacology
Anna Budny, Filip Novák, Nicolas Plumeré, B. Schetter, Bernd Speiser, Diana Straub, Hermann A. Mayer, Michaela Reginek,
Nonporous spherical silica nanoparticles resulting from a controlled Stöber process are covalently surface modified with redox-active molecules. Ferrocene, a ruthenium(II) complex with an N2P2Cl2 ligand set, and a sterically hindered biphenylamine are used as modifiers. The resulting materials are characterized by physical, spectroscopic, electrochemical, and chemical methods. The cyclic voltammetric behavior is studied in detail and reveals effects of charge transport by electron hopping along ...
Tópico(s): Mesoporous Materials and Catalysis
2006 - American Chemical Society | Langmuir
Filip Novák, Bernd Speiser, Hani A. Y. Mohammad, Hermann A. Mayer,
Abstract The electrochemical properties of a promising catalyst for CH bond activation are investigated. This P–C–P-pincer complex of iridium exhibits an intramolecular CH oxidative addition at room temperature, which becomes enhanced upon oxidation. The reaction product is detected by cyclic voltammetry. Mechanistic, kinetic, and thermodynamic information is extracted from experiments in combination with digital simulation. Multicycle voltammograms and voltammograms of mixtures consistently suggest ...
Tópico(s): CO2 Reduction Techniques and Catalysts
2004 - Elsevier BV | Electrochimica Acta
Hani A. Y. Mohammad, Jost C. Grimm, Klaus Eichele, Hans‐Georg Mack, Bernd Speiser, Filip Novák, Gloria Quintanilla, William C. Kaska, Hermann A. Mayer,
Treatment of 4-MeO-C6H3-2,6-(CH2PtBu2)2 with IrCl3·nH2O in i-PrOH/H2O gives a cyclometalated pincer chlorohydrido iridium complex. A second intramolecular oxidative addition reaction of one of the tert-butyl C−H bonds to the Ir(III) center followed by the reductive elimination of H2 gives a novel doubly metalated compound that is stable to air and water. X-ray crystallographic analysis revealed a chelated square-pyramidal iridium compound with two cyclometalated five-membered rings in the basal ...
Tópico(s): Catalytic C–H Functionalization Methods
2002 - American Chemical Society | Organometallics
Kateřina Lněničková, Hana Svobodová, Lenka Skálová, Martin Ambrož, Filip Novák, Petra Matoušková,
1. Sesquiterpenes, constituents of plant essential oil, are popular bioactive compounds due to the positive effect on human health, but their potential toxicity and possible herb-drug interactions are often omitted. In our in vivo study, we followed up the effect of p.o. administration of two sesquiterpenes β-caryophyllene oxide (CAO) and trans-nerolidol (NER) on various xenobiotic-metabolizing enzymes in mice liver and small intestine. 2. To spot the early effect of studied compounds, enzymatic activity ...
Tópico(s): Pharmacological Effects of Natural Compounds
2017 - Taylor & Francis | Xenobiotica
Viktor Řehák, Filip Novák, Igor Čepčiansky,
Tópico(s): Chemistry and Chemical Engineering
1973 - Wiley-VCH | Collection of Czechoslovak Chemical Communications
Summary Stannian andradite occurs with pyroxene and carbonates, with blende and pyrite as accessories in a skarn deposit in the Plavno mine, Krušné Hory Mts., NW. Bohemia. The green crystals are rhombic dodecahedra up to 3 cm in size. Sp. gr. 3·78; n 1·879; a 12·079±0·002 Å. Quantitative chemical and spectrographic analyses are given; the composition is (Ca 2·96 Mg 0·04 Mn 0·02 ) 3·02 (Si 2·95 Sn 0·04 ) 2·99 O 12 . The content of tin (SnO 2 1·07 %) is isomorphously bound in the lattice, and according to crystallochemical ...
Tópico(s): Geological and Geochemical Analysis
1965 - | Mineralogical Magazine and Journal of the Mineralogical Society
Filip Novák, Viktor Walter, Pavel Petráček, Tomáš Báča, Martin Saska,
A novel approach for achieving fast evasion in self-localized swarms of Unmanned Aerial Vehicles (UAVs) threatened by an intruding moving object is presented in this paper. Motivated by natural self-organizing systems, the presented approach of fast and collective evasion enables the UAV swarm to avoid dynamic objects (interferers) that are actively approaching the group. The main objective of the proposed technique is the fast and safe escape of the swarm from an interferer ~discovered in proximity. ...
Tópico(s): UAV Applications and Optimization
2021 - IOP Publishing | Bioinspiration & Biomimetics
Domagoj Leljak, Blaženka Melić, Filip Novák, M. Reboud, Danny van Dyk,
A bstract We fit the available data on exclusive semileptonic b → uℓ − $$ \overline{\nu} $$ ν ¯ decays within the Standard Model and in the Weak Effective Theory. Assuming Standard Model dynamics, we find $$ \left|{V}_{ub}\right|={3.59}_{-0.12}^{+0.13}\times {10}^{-3} $$ V ub = 3.59 − 0.12 + 0.13 × 10 − 3 . Lifting this assumption, we obtain stringent constraints on the coefficients of the ubℓν sector of the Weak Effective Theory. Performing a Bayesian model comparison, we find that a beyond the Standard Model interpretation is ...
Tópico(s): Physics of Superconductivity and Magnetism
2023 - Springer Nature | Journal of High Energy Physics
Filip Novák, Nicolas Plumeré, B. Schetter, Bernd Speiser, Diana Straub, Hermann A. Mayer, Michaela Reginek, Klaus Albert, Georg Fischer, Christoph Meyer, Hans‐Joachim Egelhaaf, B. Børresen,
Tópico(s): Mesoporous Materials and Catalysis
2009 - Springer Science+Business Media | Journal of Solid State Electrochemistry
Hani A. Y. Mohammad, Jost C. Grimm, Klaus Eichele, Hans‐Georg Mack, Bernd Speiser, Filip Novák, William C. Kaska, Hermann A. Mayer,
Treatment of 4-X-C6H3-2,6-(CH2P'Bu2)2 (X = H (1), NO2 (2), MeO (3)) with IrCl3 nH2O in 2-propanol/water generates the corresponding cyclometalated pincer chlorohydrido iridium complexes (1a - 3a). In the case of 3, a second intramolecular oxidative addition reaction of one of the t-butyl C-H bonds to the Ir(III) center, followed by the reductive elimination of H2, gives the novel doubly metalated compound 3b, which is stable to air and water. Comparative electrochemical studies of 1a and 3a establish an ...
Tópico(s): Coordination Chemistry and Organometallics
2004 - American Chemical Society | ACS symposium series
Radek Škoda, Jan Cempírek, Jan Filip, Milan Novák, František Veselovský, Radim Čtvrtlík,
Allanite-(Nd), ideally CaNdAl2Fe2+(SiO4)(Si2O7)O(OH), the Nd-analog of allanite-(Ce), occurs in the Åskagen pegmatite, central Sweden. It forms fine-grained aggregates within altered thalénite-(Y). The other associated minerals include: iimoriite-(Y), keiviite-(Y), allanite-(Y), and tengerite-(Y). Allanite-(Nd) is biaxial (-); with refractive indices α = 1.723(5), β = 1.754(7), γ = 1.772(5), and measured 2V = 82°(±3°). Larger fragments of allanite-(Nd) are moderately pleochroic (α = pale grayishbrown, γ = grayish- ...
Tópico(s): X-ray Diffraction in Crystallography
2012 - Mineralogical Society of America | American Mineralogist
Jan Filip, M. Novák, A. Beran, Radek Zbořil,
Tópico(s): Nuclear materials and radiation effects
2005 - Springer Science+Business Media | Physics and Chemistry of Minerals
Abeer Abdullah Al Anazi, Luis Andrés Barboza Arenas, Rosario Mireya Romero‐Parra, R. Sivaraman, Maytham T. Qasim, Sara Hakem Al-Khafaji, M. Abdulfadhil Gatea, Reza Alayi, Waqas Farooq, Michał Jasiński, Zbigniew Leonowicz, Filip Novak, Radomír Goňo,
The system presented in this paper can change the energy storage landscape by having the advantages of a compressed air storage system and pump storage, as well as minimizing the disadvantages of these two systems. One of the advantages of this system compared to similar systems is the lack of combustion of natural gas. Correspondingly, for construction, it does not require specific specifications for the executive site, and control of the energy and heat of the system (due to the use of water as ...
Tópico(s): Advanced Battery Technologies Research
2023 - Multidisciplinary Digital Publishing Institute | Energies
Sonka Reimers, Dominik Kriegner, Olena Gomonay, Dina Carbone, Filip Křížek, V. Novák, R. P. Campion, Francesco Maccherozzi, Alexander Björling, O. J. Amin, Luke X. Barton, Stuart F. Poole, Khalid Omari, Jan Michalička, Ondřej Man, Jairo Sinova, T. Jungwirth, P. Wadley, S. S. Dhesi, K. W. Edmonds,
Efficient manipulation of antiferromagnetic (AF) domains and domain walls has opened up new avenues of research towards ultrafast, high-density spintronic devices. AF domain structures are known to be sensitive to magnetoelastic effects, but the microscopic interplay of crystalline defects, strain and magnetic ordering remains largely unknown. Here, we reveal, using photoemission electron microscopy combined with scanning X-ray diffraction imaging and micromagnetic simulations, that the AF domain ...
Tópico(s): Multiferroics and related materials
2022 - Nature Portfolio | Nature Communications
Michal Janovec, Jozef Čerňan, Filip Škultéty, Andrej Novák,
In this article, we propose the parameters of a battery that would be suitable for the conceptual design of a small training aircraft. The mass design of the battery is based on the requirements for real training flights performed by students in pilot training. Such a serial hybrid propulsion aircraft could be used in our UNIZA aviation, training and education center for pilot training. Due to socio-political pressures in reducing emissions generated by vehicles, there has also been massive research ...
Tópico(s): Rocket and propulsion systems research
2021 - Multidisciplinary Digital Publishing Institute | Energies
Andrej Thurzo, Filip Kočiš, Bohušlav Novák, Ladislav Czakó, Ivan Varga,
Three-dimensional (3D) printing with biocompatible resins offers new competition to its opposition—subtractive manufacturing, which currently dominates in dentistry. Removing dental material layer-by-layer with lathes, mills or grinders faces its limits when it comes to the fabrication of detailed complex structures. The aim of this original research was to design, materialize and clinically evaluate a functional and resilient shape of the orthodontic power-arm by means of biocompatible 3D printing. ...
Tópico(s): Orthodontics and Dentofacial Orthopedics
2021 - Multidisciplinary Digital Publishing Institute | Applied Sciences
Luboš Běhálek, Martin Borůvka, P. M. Brdlik, Jiří Habr, Petr Lenfeld, Dora Kroisová, Filip Veselka, Jan Novák,
Tópico(s): Microplastics and Plastic Pollution
2020 - Springer Science+Business Media | Journal of Thermal Analysis and Calorimetry
David Cuesta–Frau, Jakub Schneider, Eduard Bakštein, Pavel Vostatek, Filip Španiel, Daniel Novák,
Bipolar Disorder (BD) is an illness with high prevalence and a huge social and economic impact. It is recurrent, with a long-term evolution in most cases. Early treatment and continuous monitoring have proven to be very effective in mitigating the causes and consequences of BD. However, no tools are currently available for a massive and semi-automatic BD patient monitoring and control. Taking advantage of recent technological developments in the field of wearables, this paper studies the feasibility ...
Tópico(s): Complex Systems and Time Series Analysis
2020 - Multidisciplinary Digital Publishing Institute | Entropy
Pavel Salvetr, Jaromír Dlouhý, Andrea Školáková, Filip Průša, Pavel Novák, Miroslav Karlı́k, Petr Haušild,
Ni-Ti alloys are considered to be very important shape memory alloys with a wide application area including, e.g., biomaterials, actuators, couplings, and components in automotive, aerospace, and robotics industries. In this study, the NiTi46 (wt.%) alloy was prepared by a combination of self-propagating high-temperature synthesis, milling, and spark plasma sintering consolidation at three various temperatures. The compacted samples were subsequently heat-treated at temperatures between 400 °C and ...
Tópico(s): Shape Memory Alloy Transformations
2019 - Multidisciplinary Digital Publishing Institute | Materials
Anna Bravermanová, Michaela Viktorinová, Filip Tylš, Tomáš Novák, Renata Androvičová, Jakub Korčák, Jiřı́ Horáček, Marie Balı́ková, Inga Griškova-Bulanova, Dominika Danielová, Přemysl Vlček, Pavel Mohr, Martin Brunovský, Vlastimil Koudelka, Tomáš Páleníček,
Tópico(s): Biochemical Analysis and Sensing Techniques
2018 - Springer Science+Business Media | Psychopharmacology
Miroslav Mikolášek, Peter Ondrejka, Filip Chymo, Patrik Novák, Milan Pavúk, I. Νovotný, V. Řeháček, Juraj Breza, Á. Vincze, I. Hotový,
A novel approach based on the application of light irradiation during the electrodeposition is proposed to prepare Cu2O structures for photoelectrochemical water splitting. Potentiostatic deposition of Cu2O layers under irradiation and in the dark was carried out from lactate-stabilized copper sulfate on Ag coated glass substrates. The higher growth speed for light deposited samples is related to the contribution of photogenerated carriers to the reduction of electrolyte and electrodeposition of ...
Tópico(s): Electronic and Structural Properties of Oxides
2018 - Elsevier BV | Applied Surface Science
Filip Španiel, Tomáš Novák, Lucie Bankovská Motlová, J Capková, Andrea Slováková, Pavel Trančík, Martin Matějka, Cyril Höschl,
Accessible summary Exposure to psychotic states has detrimental effects on the long‐term outcome of schizophrenia and brain integrity. Therefore, improving relapse prevention is a key component of long‐term management of schizophrenia. Previous studies using continuous monitoring of an individual's early signs of relapse and adopting preventative pharmacological interventions, when early signs are detected, showed promising clinical results in terms of relapse risk reduction. This 18‐month multi‐ ...
Tópico(s): Tryptophan and brain disorders
2015 - Wiley | Journal of Psychiatric and Mental Health Nursing
Jiřı́ Horáček, Jaroslav Flegr, Jaroslav Tintěra, Karin Verebova, Filip Španiel, Tomáš Novák, Martin Brunovský, Vĕra Bubeníková‐Valešová, David Holub, Tomáš Páleníček, Cyril Höschl,
Objectives. To address the role of latent T. gondii infection in schizophrenia we studied the influence of latent toxoplasmosis on brain morphology. Methods. An optimized voxel-based morphometry of magnetic resonance imaging was analyzed by analysis of variance with diagnosis and seropositivity as factors in 44 schizophrenic patients (12 T. gondii positive) and 56 controls (13 T. gondii positive). Results. Grey matter (GM) volume was reduced in schizophrenia patients compared with controls in the cortical ...
Tópico(s): Herpesvirus Infections and Treatments
2011 - Taylor & Francis | The World Journal of Biological Psychiatry
Zdeněk Kašpar, M. Surýnek, Jan Zubáč, Filip Křížek, V. Novák, R. P. Campion, M. S. Wörnle, Pietro Gambardella, X. Martí, Petr Němec, K. W. Edmonds, Sonka Reimers, O. J. Amin, Francesco Maccherozzi, S. S. Dhesi, P. Wadley, J. Wunderlich, K. Olejník, T. Jungwirth,
Antiferromagnets are of potential use in the development of spintronic devices due to their ultrafast dynamics, insensitivity to external magnetic fields and absence of magnetic stray fields. Similar to their ferromagnetic counterparts, antiferromagnets can store information in the orientations of the collective magnetic order vector. However, the readout magnetoresistivity signals in simple antiferromagnetic films are weak, and reorientation of the magnetic order vector via optical excitation has ...
Tópico(s): Neural Networks and Reservoir Computing
2020 - Nature Portfolio | Nature Electronics
O. J. Amin, Stuart F. Poole, Sonka Reimers, L. X. Barton, A. Dal Din, Francesco Maccherozzi, S. S. Dhesi, V. Novák, Filip Křížek, J. S. Chauhan, R. P. Campion, A. W. Rushforth, T. Jungwirth, Oleg A. Tretiakov, K. W. Edmonds, P. Wadley,
Topologically protected magnetic textures are promising candidates for information carriers in future memory devices, as they can be efficiently propelled at very high velocities using current-induced spin torques. These textures-nanoscale whirls in the magnetic order-include skyrmions, half-skyrmions (merons) and their antiparticles. Antiferromagnets have been shown to host versions of these textures that have high potential for terahertz dynamics, deflection-free motion and improved size scaling ...
Tópico(s): Advanced Condensed Matter Physics
2023 - Nature Portfolio | Nature Nanotechnology
Ana Borovečki, Marko Ćurković, Krunoslav Nikodem, Stjepan Orešković, Milivoj Novak, Filip Rubić, Jurica Vuković, Diana Špoljar, Bert Gordijn, Chris Gastmans,
Abstract Background There has been no in-depth research of public attitudes on withholding or withdrawing life-prolonging treatment, euthanasia, assisted suicide and physician assisted suicide in Croatia. The aim of this study was to examine these attitudes and their correlation with sociodemographic characteristics, religion, political orientation, tolerance of personal choice, trust in physicians, health status, experiences with death and caring for the seriously ill, and attitudes towards death ...
Tópico(s): Patient Dignity and Privacy
2022 - BioMed Central | BMC Medical Ethics
Tomáš Czakoj, Michal Košťál, Marek Zmeškal, Evžen Novák, Filip Mravec, František Cvachovec, Jan Šimon, Martin Schulc, Radim Uhlář, P. Alexa, Zdeněk Matěj,
Using D–T generators as a neutron source for precise measurements requests a well-known neutron spectrum and spatial distribution of neutron flux. It is important in cross section measurements as well as in deep penetration issues. Thus, it is very important not only to validate the fluence accurately but also accurately validate the neutron spectrum in various positions. Experimental validation of two different D–T neutron generator experiments was performed using proton recoil method. Measurements ...
Tópico(s): Atomic and Subatomic Physics Research
2022 - Elsevier BV | Nuclear Instruments and Methods in Physics Research Section A Accelerators Spectrometers Detectors and Associated Equipment
A. V. Andronikov, Martin Novák, Filip Oulehle, Vladislav Chrastný, Ondřej Šebek, Irina E. Andronikova, Markéta Štěpánová, Adéla Šípková, Jakub Hruška, Oldřích Myška, Tomáš Chuman, František Veselovský, Jan Čuřík, Eva Přechová, Arnošt Komárek,
In highly industrialized, densely populated parts of Central Europe, mobilization of legacy Zn pollution from forest ecosystems may negatively affect the quality of water resources. To test this hypothesis, we determined the 66Zn/64Zn isotope ratios of 15 Zn reservoirs and fluxes in an acidified, spruce die-back affected mountain-slope catchment in northern Czech Republic. The δ66Zn values of precipitation, organic horizon, and runoff were statistically indistinguishable. In contrast, δ66Zn values ...
Tópico(s): Groundwater and Isotope Geochemistry
2021 - American Chemical Society | Environmental Science & Technology