... Friars Minor Conventual, the proprietors of the Church, Filippo della Valle erected a moving monument to contain her heart ...
Tópico(s): Scottish History and National Identity
1987 - Truman State University | Sixteenth Century Journal
Luca Moretti, Andrea Mazzanti, Arianna Rossetti, Andrea Schirato, Laura Polito, Fabio Pizzetti, Alessandro Sacchetti, Giulio Cerullo, Giuseppe Della Valle, Filippo Rossi, Margherita Maiuri,
Abstract Plasmonic nanoparticles (NPs) are exploited to concentrate light, provide local heating and enhance drug release when coupled to smart polymers. However, the role of NP assembling in these processes is poorly investigated, although their superior performance as nanoheaters has been theoretically predicted since a decade. Here we report on a compound hydrogel (agarose and carbomer 974P) loaded with gold NPs of different configurations. We investigate the dynamics of light-heat conversion in ...
Tópico(s): Nanoparticle-Based Drug Delivery
2020 - De Gruyter | Nanophotonics
Maria Dolci, Chiara Favero, Letizia Tarantini, Sonia Villani, Marco Bregni, Lucia Signorini, Alberto Della Valle, Filippo Crivelli, Sarah D’Alessandro, Pasquale Ferrante, Valentina Bollati, Serena Delbue,
Tópico(s): Genetic factors in colorectal cancer
2020 - Springer Science+Business Media | Medical Microbiology and Immunology
Tópico(s): Metallurgy and Cultural Artifacts
1984 - College Art Association | The Art Bulletin
Tópico(s): Metallurgy and Cultural Artifacts
1984 - College Art Association | The Art Bulletin
Tópico(s): Historical and Religious Studies of Rome
2007 - Burlington Magazine Publications | Burlington magazine/The Burlington magazine
Tópico(s): Architecture and Art History Studies
1997 - | Transactions of the American Philosophical Society
Filippo Consolo, L. Pozzi, Marina Pieri, Patrizia Della Valle, Alberto Redaelli, Armando D’Angelo, Federico Pappalardo,
We characterized the biologic background of prothrombotic platelet function in the setting of durable left ventricular assist devices (LVADs) evaluating the role of different antithrombotic regimens. Platelet-mediated thrombin generation was quantified using the Platelet Activity State (PAS) Assay and the Thrombin Generation Test (TGT) in 78 patients implanted with the HeartMate II (n = 10, 13%), the HeartMate 3 (HM3) (n = 30, 38%), or the HVAD (n = 38, 49%) and managed with oral anticoagulation plus aspirin ( ...
Tópico(s): Heart Failure Treatment and Management
2019 - Lippincott Williams & Wilkins | ASAIO Journal
Giovanni Perini, Vittorina Della-Bianca, Valeria Politi, Giuliano Della Valle, Ilaria Dal Prà, Filippo Rossi, Ubaldo Armato,
The neurodegenerative changes in Alzheimer's disease (AD) are elicited by the accumulation of β-amyloid peptides (Aβ), which damage neurons either directly by interacting with components of the cell surface to trigger cell death signaling or indirectly by activating astrocytes and microglia to produce inflammatory mediators. It has been recently proposed that the p75 neurotrophin receptor (p75NTR) is responsible for neuronal damage by interacting with Aβ. By using neuroblastoma cell clones lacking ...
Tópico(s): Alzheimer's disease research and treatments
2002 - Rockefeller University Press | The Journal of Experimental Medicine
Francesca Ravanetti, Roberto Chiesa, Maria Cristina Ossiprandi, Ferdinando Gazza, Vittorio Farina, Filippo Maria Martini, Rosanna Di Lecce, Giacomo Gnudi, Cinzia Della Valle, J. Gavini, Antonio Cacchioli,
Tópico(s): Dental Implant Techniques and Outcomes
2016 - Springer Science+Business Media | Journal of Materials Science Materials in Medicine
Artem D. Sinelnik, Shiu Hei Lam, Filippo Coviello, Sebastian Klimmer, Giuseppe Della Valle, Duk‐Yong Choi, Thomas Pertsch, Giancarlo Soavi, Isabelle Staude,
Optical communication can be revolutionized by encoding data into the orbital angular momentum of light beams. However, state-of-the-art approaches for dynamic control of complex optical wavefronts are mainly based on liquid crystal spatial light modulators or miniaturized mirrors, which suffer from intrinsically slow (µs-ms) response times. Here, we experimentally realize a hybrid meta-optical system that enables complex control of the wavefront of light with pulse-duration limited dynamics. Specifically, ...
Tópico(s): Photoreceptor and optogenetics research
2024 - Nature Portfolio | Nature Communications
Filippo Consolo, Alessandra Marasi, Patrizia Della Valle, Marta Bonora, Marina Pieri, Anna Mara Scandroglio, Alberto Redaelli, Alberto Zangrillo, Armando D’Angelo, Federico Pappalardo,
To evaluate the competing pro-haemorrhagic contribution of acquired von Willebrand (vW) disease and antithrombotic therapy in patients implanted with continuous-flow left ventricular assist devices (LVADs).We compared the extent of vW factor (vWf) degradation [vWf antigen (vWf:Ag)] and a decrease of functional activity of large vWf multimers [vWf collagen binding (vWf:CB)] in LVAD patients who did and did not suffer from bleeding. Data were measured pre-implant, at short-term (t1: 12 months) follow-up. ...
Tópico(s): Heart Failure Treatment and Management
2021 - Oxford University Press | European Journal of Cardio-Thoracic Surgery
Vittorina Della-Bianca, Filippo Rossi, Ubaldo Armato, Ilaria Dal Prà, Claudio Costantini, Giovanni Perini, Valeria Politi, Giuliano Della Valle,
In this work we have investigated the molecular basis of the neuronal damage induced by the prion peptide by searching for a surface receptor whose activation could be the first step of a cascade of events responsible for cell death. By using a human neuroblastoma cell line lacking all the neurotrophin receptors and derived clones expressing the full-length or truncated forms of the low affinity neurotrophin receptor (p75 NTR ), we have been able to demonstrate that the neuronal death induced by the ...
Tópico(s): RNA regulation and disease
2001 - Elsevier BV | Journal of Biological Chemistry
... is a marble Cupid and Psyche group by Filippo della Valle (no. 140; c.1730), long attributed to the ...
Tópico(s): Aesthetic Perception and Analysis
2016 - Oxford University Press | Journal of the History of Collections
Filippo Consolo, Patrizia Della Valle, Marco Saracino, Marta Bonora, Giovanni Donadoni, Fabio Ciceri, Moreno Tresoldi, Armando D’Angelo, Giovanni Landoni, Alberto Zangrillo,
Platelet activation at the early stage of COVID-19 is poorly described. The need for antiplatelet therapy in patients with COVID-19 remains controversial. We characterized the platelet activation profile in hospitalized patients at the early stage of COVID-19 using the modified prothrombinase Platelet Activation State (PAS) Assay.Sixteen patients admitted to the emergency department of the IRCCS San Raffaele Hospital (Milan, Italy) between February 8 and April 2021 were enrolled. All patients presented ...
Tópico(s): Long-Term Effects of COVID-19
2022 - Edizioni Minerva Medica | Minerva Anestesiologica
Filippo Consolo, Giulia Sferrazza, Giulia Motolone, Rachele Contri, Lorenzo Valerio, Rosalba Lembo, L. Pozzi, Patrizia Della Valle, Michele De Bonis, Alberto Zangrillo, Gianfranco Beniamino Fiore, Alberto Redaelli, Marvin J. Slepian, Federico Pappalardo,
Aims To correlate the dynamics of platelet activation with the development of thromboembolic events in patients with continuous‐flow left ventricular assist device (cf‐LVAD). Methods and results The platelet activity state (PAS) assay was utilized to evaluate platelet activation in 68 cf‐LVAD patients implanted with the HeartMate II ( n = 15, 22%), HeartMate 3 ( n = 15, 22%), or HeartWare HVAD ( n = 38, 56%). PAS was measured preoperatively, early post‐implant, and at long‐term follow‐up (1, 3, 6, 12, 18, and ...
Tópico(s): Heart Failure Treatment and Management
2017 - Elsevier BV | European Journal of Heart Failure
Valentina D’Angelo, Maria Carmela Piccirillo, Massimo Di Maïo, Ciro Gallo, Elena Di Girolamo, P. Marone, Giovanni Battista Rossi, Corrado Civiletti, Marco Romano, Agnese Miranda, Domenico Taranto, Gabriella Sessa, Pasquale Esposito, Raffaele Salerno, R. Pumpo, F.R. De Filippo, Elisabetta Della Valle, Mario De Bellis, Francesco Perrone,
... Esposito, Raffaele Salerno, Rossella Pumpo, Francesca Romana De Filippo, Elisabetta Della Valle and Mario de Bellis have nothing to disclose ...
Tópico(s): Gastric Cancer Management and Outcomes
2020 - RELX Group (Netherlands) | SSRN Electronic Journal
J. Harms, Filippo Ambrosino, L. Angelini, V. Braito, M. Branchesi, E. Brocato, E. Cappellaro, E. Coccia, M. W. Coughlin, R. Della Ceca, M. Della Valle, C. Dionisio, Costanzo Federico, V. Formisano, A. Frigeri, A. Grado, L. Izzo, A. Marcelli, Andrea Maselli, Marco Olivieri, Claudio Pernechele, Andrea Possenti, S. Ronchini, Roberto Serafinelli, P. Severgnini, Maila Agostini, F. Badaracco, A. Bertolini, Lorenzo Betti, M. Civitani, Christophe Collette, S. Covino, S. Dall’Osso, P. D’Avanzo, R. DeSalvo, Matteo Di Giovanni, Mauro Focardi, Carlo Giunchi, J. V. van Heijningen, N. Khetan, Daniele Melini, Giuseppe Mitri, C. M. Mow–Lowry, L. Naponiello, Vladimiro Noce, G. Oganesyan, E. Pace, Ho Jung Paik, Alessandro Pajewski, E. Palazzi, M. Pallavicini, Giovanni Pareschi, Riccardo Pozzobon, A. Sharma, Giorgio Spada, R. Stanga, G. Tagliaferri, Raffaele Votta,
Abstract Monitoring of vibrational eigenmodes of an elastic body excited by gravitational waves was one of the first concepts proposed for the detection of gravitational waves. At laboratory scale, these experiments became known as resonant bar detectors first developed by Joseph Weber in the 1960s. Due to the dimensions of these bars, the targeted signal frequencies were in the kHz range. Weber also pointed out that monitoring of vibrations of Earth or the Moon could reveal gravitational waves ...
Tópico(s): Geophysics and Sensor Technology
2021 - IOP Publishing | The Astrophysical Journal
Leonardo Provenzano, Silvia Damian, Matteo Duca, S. Della Valle, Filippo de Braud,
The brief report by Kalchiem-Dekel et al. 1 Kalchiem-Dekel O. Falcon C.J. Bestvina C.M. et al. Brief report: chylothorax and chylous ascites during RET tyrosine kinase inhibitor therapy. J Tho Oncol. 2022; 17: 1130-1136 Abstract Full Text Full Text PDF PubMed Scopus (5) Google Scholar interestingly described the occurrence of spontaneous chylous effusions in patients who underwent treatment with multiple tyrosine kinase inhibitors and specific RET inhibitors. In particular, the incidence of this ...
Tópico(s): Pleural and Pulmonary Diseases
2023 - Elsevier BV | Journal of Thoracic Oncology
Filippo Trentini, Valentina Marziano, Giorgio Guzzetta, Marcello Tirani, Danilo Cereda, Piero Poletti, Raffaella Piccarreta, Antonio Barone, Giuseppe Preziosi, Fabio Arduini, Petra Giulia Della Valle, Alberto Zanella, Francesca Grosso, Gabriele Del Castillo, Ambra Castrofino, Giacomo Grasselli, Alessia Melegaro, Alessandra Piatti, Aida Andreassi, Maria Gramegna, Marco Ajelli, Stefano Merler,
Abstract During the spring of 2020, the coronavirus disease 2019 (COVID-19) epidemic caused an unprecedented demand for intensive-care resources in the Lombardy region of Italy. Using data on 43,538 hospitalized patients admitted between February 21 and July 12, 2020, we evaluated variations in intensive care unit (ICU) admissions and mortality over the course of 3 periods: the early phase of the pandemic (February 21–March 13), the period of highest pressure on the health-care system (March 14–April ...
Tópico(s): COVID-19 Clinical Research Studies
2021 - Oxford University Press | American Journal of Epidemiology
Andrea Schirato, Luca Moretti, Elisa Lacroce, Laura Polito, Filippo Rossi, Giuseppe Della Valle, Margherita Maiuri,
Plasmonic nanostructures are, to date, well-known to offer unique possibilities for the tailoring of light–matter interactions at the nanoscale. Most recently, a new route to ultrafast all-optical modulation has been disclosed by combining the resonant features of plasmonic nanostructures with the giant third-order optical nonlinearity of noble metals regulated by highly energetic (hot) carriers. In this framework, a variety of nanostructures have been designed, with special attention to shapes featuring ...
Tópico(s): Orbital Angular Momentum in Optics
2024 - American Chemical Society | The Journal of Physical Chemistry C
Karim Kassem, Michela Sperti, Andrea Cavallo, Andrea Mario Vergani, Davide Fassino, Monica Moz, Alessandro Liscio, Riccardo Banali, Fried-Michael Dahlweid, Luciano Benetti, Francesco Bruno, Guglielmo Gallone, Ovidio De Filippo, Mario Iannaccone, Fabrizio D’Ascenzo, Gaetano Maria De Ferrari, Umberto Morbiducci, Emanuele Della Valle, Marco A. Deriu,
In everyday clinical practice, medical decision is currently based on clinical guidelines which are often static and rigid, and do not account for population variability, while individualized, patient-oriented decision and/or treatment are the paradigm change necessary to enter into the era of precision medicine. Most of the limitations of a guideline-based system could be overcome through the adoption of Clinical Decision Support Systems (CDSSs) based on Artificial Intelligence (AI) algorithms. However, ...
Tópico(s): Artificial Intelligence in Healthcare and Education
2024 - Elsevier BV | Artificial Intelligence in Medicine
Valentina D’Angelo, Maria Carmela Piccirillo, Massimo Di Maïo, Ciro Gallo, Cristina Bucci, Corrado Civiletti, Elena Di Girolamo, P. Marone, Giovanni Battista Rossi, Alfonso Tempesta, Maura Tracey, Marco Romano, Agnese Miranda, Domenico Taranto, Gabriella Sessa, Pasquale Esposito, Raffaele Salerno, R. Pumpo, F.R. De Filippo, Elisabetta Della Valle, Mario De Bellis, Francesco Perrone,
Background Adequate bowel preparation before colonoscopy is crucial. Unfortunately, 25% of colonoscopies have inadequate bowel cleansing. From a patient perspective, bowel preparation is the main obstacle to colonoscopy. Several low-volume bowel preparations have been formulated to provide more tolerable purgative solutions without loss of efficacy. Objectives Investigate efficacy, safety, and tolerability of Sodium Picosulphate plus Magnesium Citrate (SPMC) vs. Polyethylene Glycol plus Ascorbic ...
Tópico(s): Pancreatic and Hepatic Oncology Research
2022 - Frontiers Media | Frontiers in Medicine
Alessandro Molinelli, Andrea Schirato, Luca Moretti, Giuseppe Della Valle, Margherita Maiuri, Filippo Rossi,
Abstract Hydrogel nanocomposites have lately taken part in the biomaterials scenario for several applications in the biomedical field, e. g., drug delivery, biosensing and cancer therapy. The inclusion of a broad variety of nanomaterials inside the hydrogel matrix leads to the successful development of hybrid platforms with superior and advantageous features. In this way, finely designed nano‐systems can be obtained, which are able to overcome the intrinsic limitations of conventional hydrogels, ...
Tópico(s): Nanoparticle-Based Drug Delivery
2024 - Wiley | ChemNanoMat
Filippo Consolo, L. Pozzi, Giulia Sferrazza, Patrizia Della Valle, Armando D’Angelo, Marvin J. Slepian, Federico Pappalardo,
In patients with left ventricular assist device support and aspirin allergy, the choice of effective antiplatelet strategy remains a challenge. We compared the antithrombotic effect of clopidogrel vs ticagrelor in an LVAD patient with aspirin allergy by using a modified protocol of the thrombin generation test, accounting selectively for the platelet contribution on thrombin generation. Our results demonstrate enhanced antithrombotic efficacy offered by ticagrelor. Consistent with experimental results, ...
Tópico(s): Heart Failure Treatment and Management
2018 - Elsevier BV | The Annals of Thoracic Surgery
Fabio Puglisi, Marcello Ceppi, Francesco Cognetti, Sabino De Placido, Paolo Bruzzi, Michelino De Laurentiis, Giancarlo Bisagni, Giovanna Cavazzini, Antonio Durando, Anna Turletti, Elisabetta Della Valle, Filippo Montemurro, Sandro Barni, Andrea Ardizzoni, Teresa Gamucci, Giuseppe Colantuoni, Lucia Del Mastro,
Abstract Background In patients with node-positive early breast cancer (EBC), dose-dense adjuvant chemotherapy improves disease-free survival (DFS) compared with standard interval chemotherapy. The GIM2 trial supports the value of dose-dense chemotherapy and suggests that the benefit is present in patients with hormone receptor-negative or hormone receptor-positive tumours (Del Mastro et al. Lancet 2015). In order to individualize decision making, there is a need to examine the absolute treatment effects ...
Tópico(s): Multiple and Secondary Primary Cancers
2017 - American Association for Cancer Research | Cancer Research
Agostino Fortunato, Filippo Rumi, Massimo Zazzetta, Marco Della Valle, Vincenzo Pedace, Americo Cicchetti,
Introduction: An ostomy is a procedure in which an opening is made in the abdominal wall to establish a communication between the intestinal or urinary system and the external environment. Peristomal skin complications pose a constant challenge for the majority of individuals with a stoma, as they represent the most common postoperative complication. The aim of this study was to develop an economic evaluation model for assessing the costs associated with peristomal skin complications. Methods: In ...
Tópico(s): Anorectal Disease Treatments and Outcomes
2024 - SAGE Publishing | Global & Regional Health Technology Assessment
Consolo Filippo, Pozzi Loris, Sferrazza Giulia, Della Valle Patrizia, D’Angelo Armando, J Slepian Marvin, Pappalardo Federico,
2018 - Elsevier BV | The Annals of Thoracic Surgery
Caterina Fontanella, Lucia Del Mastro, Sabino De Placido, Michelino De Laurentiis, C. Boni, Giovanna Carrà, Antonio Durando, Anna Turletti, A. Turletti, Cecilia Nisticò, Elisabetta Della Valle, O. Garrone, Filippo Montemurro, Sandro Barni, Andrea Ardizzoni, Teresa Gamucci, Giuseppe Colantuoni, C. Bighin, F. Cognetti, Fabio Puglisi,
Background: At the 2016 ASCO meeting we presented the prognostic STAR score, designed in a dataset of 4,646 pts with Luminal-like (HER2-/estrogen receptor [ER]+) early breast cancer (BC) combining tumor stage (AJCC Cancer Staging 7th), progesterone receptor [PR] status, and age at baseline. In this study we explored the prognostic value of the STAR score in the adjuvant GIM2 trial dataset, according to chemotherapy dose density. Methods: We analyzed 1,610 pts with Luminal-like BC from the 2x2 factorial ...
Tópico(s): Cancer Treatment and Pharmacology
2016 - Elsevier BV | Annals of Oncology
Alessandra Fabi, D. Alesini, Elisabetta Della Valle, Luisa Carbognin, Grazia Arpino, Filippo Montemurro, Mariangela Ciccarese, Katia Cannita, Ida Paris, MC Cursano, Luca Moscetti, G. Ferretti, Michelino De Laurentiis, Alberto Zambelli, Nicla La Verde, Cecilia Nisticò, Simona Gasparro, Diana Giannarelli, Francesco Cognetti,
Abstract Background: Ado-trastuzumab emtansine (T-DM1) is a drug-antibody conjugate whose activity has been confirmed in HER2+ advanced breast cancer (BC) patients by the phase 3 EMILIA trial (Verma et al, NEJM 2012). Within the 991 patients enrolled in this trial, about 10% were affected with brain metastases (BM); in this subgroup, safety and efficacy of T-DM1 were confirmed although without any PFS improvement. Patients and methods: In an Italian, multicenter, retrospective analysis involving 303 ...
Tópico(s): HER2/EGFR in Cancer Research
2018 - American Association for Cancer Research | Cancer Research