Jonathan Northcroft, Tracey Boles, Waldemar Januszczak, Cosmo Lanesman, Hala Jaber, John Dugdale, Matthew Wall, Mark McCrum, Helena Frith Powell, Nigel Botherway, Tom Winger, Fred Redwood, Rob Tooth, Jim Munro, Sally Brock, Helen Davies, David Sloan, Tim Albone, Robert Muir, Trish Lorenz, Rob Hughes, Thierry Henry, Dr Simon Coleman, Peter Whittle, John Peter, Ian Freeman, Patsy Hammond, Carla Capalbo's, Michael Bond, Andrew Longmore, John Waples Business Editor, Harry Lester, Martin Kapusniak, Richard Harries, Sally Emerson, Cameron MacKintosh, Frank Whitford, Nicolette Jones, David Gower, George Thorogood, Kathryn Cooper, Paul Marinko, David Smith, Nigel Cassidy, David Cracknell Political Editor, Emma Unsworth, Heston Blumenthal's, Roberta Ward-Smith, Andrew Sullivan, Clive Davis, Brian Doggan, Ian Chritchley, Plum Sykes socialite, Flora Bagenal, Tony Allen-Mills, Simon Wilde, Mark Harvey, Martin James, Ariel Leve, Tom Walker, Anthony Sattin, Robert Winnett, Stephen Barker, Dipesh Gadher Transport Correspondent, Irwin Stelzer, Richard Wheeler, Dlpesh Gadher, Peter Wilson, Maja Dragovic, Rosie Millard, David Dougill, Emma Rubach, John Arlidge, D I Hurt, Sarah-Kate Templeton Medical Correspondent, Christober Hart, Christopher Hart, Stuart Barnes, Geraldine Hackett, Susie Andrews, Michael Gillard, Patrice de Villiers, Alec Kerr, Tim Burnham, Lauren Booth's, Shakespeare, Paul Forsyth, Hugh Mcllvanney, Cally Law, Hugh Canning, Zaharat Power-Clare, Jeremy Clarkson, David Cairns, Edward Porter, Stewart Lee, Alan Brownjohn, Jan Millington, Nicola Smith, Michael Portillo, Lloyd James, Michael Nicholson, Patricia Nicol, Sarah Dempster, Rbjt Allenby, Dave Pollard, Kevin Jackson, Anita Chaudhuri, Paul Merton, Richard Fletcher, Donna Harrington, Greg Struthers, James Delingpole, Lydia Slater, D Fey, Graham Little's, Max Hastings, Mike Laws, Peter Parker, Stuart Wavell, Sarah-Kate Templeton, Roger Eglin, Paul Donovan, Paul Owen, William Shawcross, Vincent Crump, Dr David Green Director, Paul Kimmage, Chris Woodhead, Tom Stubbs, Jasper Gerard, L Bagshaw, Paul Driver, Sue Fox, John Follain, Ian Hawkey, Joe Lovejoy football correspondent, Stuart Andrews, Shelley Von Strunckel, David Leppard, Roland Rudd Chairman, Paul Durman, Mark Edwards, Mike Aitken, Simon Mansell, Jasper Gearard, Phil Baker, Christina Lamb, Lois Rogers, Robert Booth, Raymond Keene, Alan Beadle, Don Cairns, Kate Saunders, Rod Liddle, David Goodhart, Richard Lambert, David Cracknell, Robbie Hudson, Cosmo Landesman, Mary Miller, Marie Colvin, David Walton, Kipper Williams, Emma Smith, Stephen Jones, Stephen Bleach, Barry Flatman, Louise Armitstead, Emily Perl Kingsley, Anthony Capella's, Adrienne Connors, Clive Aslet, Caroline Donald, David Scott, John Aiztewood, Nigel Lord, Nick Rennison, Ian Critchley, Helen Brown, Trevor Lewis, Jack Grimston, Colin McDowell, Jennifer Harper-Deacon, Stephen Armstrong, John Elliott, James Taylor, Alan Hollin, John Walpes Business Editor, Bethan Cole, J Wilkinson, Richard Woods, Roland White, Steven Swinford, Shane Watson, Anthea Masey, Maurice Chittenden, Peter Gill, Richard Brooks Arts Editor, Anthony James, Victoria Segal, Richard Rae, Ian Mitchell, Louise Armistead, David Mills, Jonathan Leake, Clive Davies, Liza Campbell, Penny Court, Jodie Kidd, Michael Sheridan, Sir Christopher Frayling, Clare Francis, Michael Woodville, Katharine Hibbert, Michael Smith, Chris Terrill, John Harlow, Barry Collins, Mark Kleinman, John Waples, A A Gill, Denis Walsh, Matthew Campbell, Brian Glanville, Daniel Foggo, David James, David Sanderson, Simon Jenkins, Stephen Pettitt, Richard Bridge, Deirdre Fernand, Will Iredale, Jessica Bown, Claudia Croft, Peter Zimonjic, Sally Kinnes, Glenda Brett-Holt, Daniel Emery, Nigel Powell, Sean O'brien, James Worrall, Sophie Harrison, Katherine Cave, Paul Lane, Brian Doogan, Stephen Price, John Aizlewood, Minette Marrin, Mark Hodson, Andrew Frankel, Jay Nagley, Ken Lunn, Joe Lovejoy, Jonathan Futrell, Ali Hussain, Ed Hughdos, David Budworth, Hugh Pearman, Graham Norwood, Andrew Davidson, Dan Cairns, Ed Habershon, Christopher Bray, Wendy Healiss, Gwen Thomas, David Smith Economics Editor, Marianne Bartram, David Clenton, Sarah Baxter, Alex Bellos, Barabar Hall, Joanna Simon, India Knight, Patrick Jefferson, Jason Dawe, Dominic Rushe, Jim Fleming, Sian Griffiths, Karen Robinson, Philippa Lamb, Helen Stewart,
... The Sunday Times Model boss The Big Interview: Flavio Briatore All you need is love—for business ... One playboys tells Paul Kimmage The talent spotter: Flavio Briatore Ocean brings joy and tragedy Dee Caffari' ...
2006 - Gale Group | Sunday Times HA GDA
Produção Nacional
Revisado por pares
Cristiano Freitas de Souza, Flávio de Souza Brito, Valter Correia de Lima, Antonio Carlos de Camargo Carvalho,
One of the most challenging situations in contemporary medicine is, doubtlessly, the approach and treatment of patients presenting with severe left ventricle failure. Since its first clinical application in patients with cardiogenic shock in 1968, the intraaortic balloon pump (IABP) has been widely accepted by heart failure physicians. Although IABP therapy has been shown to be effective for the support and stabilization of hemodynamically compromised patients, it has failed to promote any improvements ...
Tópico(s): Cardiac pacing and defibrillation studies
2010 - Wiley | Journal of Interventional Cardiology
Produção Nacional
Revisado por pares
Queila Daiane Fonseca do Amaral, Emanoeli da Rosa, Júlia Gabriela Wronski, Luísa Zuravski, Marcus Vinícius Morini Querol, Bruno dos Anjos, Carlos Francisco Ferreira de Andrade, Michel Mansur Machado, Luís Flávio Souza de Oliveira,
This study evaluated the Limnoperna fortunei (golden mussel) as a bioindicator of cytotoxicity and genotoxicity in aquatic environments contaminated by heavy metals. Five groups of 50 subjects each were exposed to different concentration of mercuric chloride (HgCl2) (0.001 mg/L, group I; 0.005 mg/L, group II; 0.01 mg/L, group II; 0.02 mg/L, group IV; and 0.1 mg/L, group V). The control group for both chronic and acute treatment did not receive HgCl2. For chronic exposure, the respective groups were ...
Tópico(s): Mercury impact and mitigation studies
2019 - Elsevier BV | The Science of The Total Environment
Produção Nacional
Revisado por pares
Camila Martins Güez, Raul Oliveira de Souza, Paula Fischer, Maria Fernanda de Moura Leão, Jonathaline Apollo Duarte, Aline Augusti Boligon, Margareth Linde Athayde, Luísa Zuravski, Luís Flávio Souza de Oliveira, Michel Mansur Machado,
Ocimum is one of the most important genera of the Lamiaceae family. Several studies about basil and its popular use reveal many characteristics of the herb, including its use as antioxidant, anti-aging, anti-inflammatory, anti-carcinogenic, anti-microbial, and cardiovascular agents, among others. In this paper, we evaluated genotoxic, oxidative, and anti-inflammatory parameters from the extract of Ocimum basilicum in different concentrations, using human leukocytes cultures exposed to challenging ...
Tópico(s): Medicinal Plants and Neuroprotection
2017 - UNIVERSIDADE DE SÃO PAULO | Brazilian Journal of Pharmaceutical Sciences
Produção Nacional
Revisado por pares
Cláudia Borges de Morais, Marina Scopel, Graziele P.R. Pedrazza, F.K. da Silva, Daiane Flores Dalla Lana, Mônica Lopes Tonello, Sílvia Teresinha Sfoggia Miotto, Michel Mansur Machado, Luís Flávio Souza de Oliveira, Alexandre Meneghello Fuentefría, José Ângelo Silveira Zuanazzi,
Intensive prophylactic use of antifungals leads to the increase of drug resistance and the need for new and more effective treatments are real. Plants from Leguminosae family are rich in flavonoids, for which numerous biological activities have been described, including antifungal effects.To screen methanolic extracts from Leguminosae species looking for alternative sources for antifungal agents (anti-dermatophyte and anti-Candida) and their innocuity.Antifungal activity was evaluated using the strains ...
Tópico(s): Essential Oils and Antimicrobial Activity
2017 - Elsevier BV | Journal de Mycologie Médicale
Produção Nacional
Revisado por pares
Raquel Balestri Heleno Ferreira, Jonathaline Apollo Duarte, Flávio Dias Ferreira, Luís Flávio Souza de Oliveira, Michel Mansur Machado, Marcelo Donadel Malesuik, Fávero Reisdorfer Paula, Martin Steppe, Elfrides Eva Shermann Schapoval, Clésio Soldateli Paim,
A stability-indicating LC method was developed for quantification of linagliptin (LGT) and three synthetic impurities. The method utilizes a Thermo Scientific® RP-8 column (100 mm × 4.6 mm; 5 μm) with the PDA detector for quantitation of impurities. A mixture of 0.1% formic acid with pH 3.5 (A) and acetonitrile (B) was used as the mobile phase at a flow rate of 0.6 mL·min-1 with gradient elution. The percentage of mobile phase B increases from 30% to 70% over 5 min and decreases from 70% to 30% between ...
Tópico(s): Inflammatory mediators and NSAID effects
2019 - Hindawi Publishing Corporation | Journal of Analytical Methods in Chemistry
Produção Nacional
Revisado por pares
Jassana Moreira Floriano, Emanoeli da Rosa, Queila Daiane Fonseca do Amaral, Luísa Zuravski, Pamella Eduardha Espindola Chaves, Michel Mansur Machado, Luís Flávio Souza de Oliveira,
The use of food colorings has a long-recorded history. Tartrazine (TRZ) is a dye that confers a lemon-yellow color to food and is widely used in the manufacture of numerous food products, as well as in pharmaceuticals and cosmetics. However, few studies have addressed the toxicology of TRZ in human cells or tissues. Considering the frequent consumption of the TRZ dye in food products and the lack of toxicological data, the present study aimed to evaluate the cytotoxicity and genotoxicity of the TRZ ...
Tópico(s): melanin and skin pigmentation
2018 - Oxford University Press | Toxicology Research
Produção Nacional
Revisado por pares
Letícia Jacobi Danielli, Bruna Pippi, Jonathaline Apollo Duarte, Ana Julia Maciel, William Lopes, Michel Mansur Machado, Luís Flávio Souza de Oliveira, Marilene Henning Vainstein, Mário Lettieri Teixeira, Sérgio Augusto de Loreto Bordignon, Alexandre Meneghello Fuentefría, Miriam Anders Apel,
The aim of this study was to evaluate the antifungal, antichemotactic and antioxidant activities of Schinus lentiscifolius essential oil, as well as its combined effect with terbinafine and ciclopirox, against dermatophytes.Essential oil was analysed by GC-MS. The antifungal activity and the mechanism of action were determined by broth microdilution, sorbitol and ergosterol assays, as well as scanning electron microscopy. The checkerboard method was used for evaluating the interactions with commercial ...
Tópico(s): Bee Products Chemical Analysis
2018 - Oxford University Press | Journal of Pharmacy and Pharmacology
Produção Nacional
Revisado por pares
Letícia Jacobi Danielli, Bruna Pippi, Krissie D. Soares, Jonathaline Apollo Duarte, Ana Julia Maciel, Michel Mansur Machado, Luís Flávio Souza de Oliveira, Sérgio Augusto de Loreto Bordignon, Alexandre Meneghello Fuentefría, Miriam Anders Apel,
Chemosentizing of pathogens using natural compounds has been shown to be a promising alternative, resulting in increased efficacy of classical antifungal therapy. This study determines the chemical composition and antifungal, antichemotactic and antioxidant activities of Nectandra Rol species. ex Rottb. essential oils species, and its interaction with commercial antifungals. The chemical composition of N. megapotamica and N. lanceolata essential oils was established by gas chromatography–mass spectrometry ( ...
Tópico(s): Phytochemistry and Biological Activities
2017 - Elsevier BV | Industrial Crops and Products
Produção Nacional
Revisado por pares
Samuel Kaiser, Ânderson Ramos Carvalho, Vanessa Pittol, Fabrícia Dietrich, Fabiana Manica, Michel Mansur Machado, Luís Flávio Souza de Oliveira, Ana Maria Oliveira Battastini, George González Ortega,
Uncaria tomentosa (Willdenow ex Roemer & Schultes) DC. (Rubiaceae) or cat's claw is a climber vine from the South American rainforest used in folk medicine for cancer treatment. Its antitumor activity has been mostly ascribed to pentacyclic oxindole alkaloids (POA) from stem bark and leaves while the activity of tetracyclic oxindole alkaloids (TOA) remains unknown. In recent times, the occurrence of three chemotypes based on its oxindole alkaloid profile was noticed in U. tomentosa, namely, chemotype ...
Tópico(s): Traditional and Medicinal Uses of Annonaceae
2016 - Elsevier BV | Journal of Ethnopharmacology
Produção Nacional
Revisado por pares
Michel Mansur Machado, Luís Flávio Souza de Oliveira, Luísa Zuravski, Raul Oliveira de Souza, Paula Fischer, Jonathaline Apollo Duarte, Manoelly Oliveira Rocha, Camila Martins Güez, Aline Augusti Boligon, Margareth Linde Athayde,
ABSTRACT Euphorbia tirucalli (L.), commonly known as aveloz, has been indiscriminately used in popular medicine to treat various illnesses. However, some components can have devastating consequences. Injury to a cell's genetic material can cause mutations, cancer, and cell death. Our main goal in this work was to evaluate the genotoxic and cytotoxic effects of E. tirucalli extract on human leukocytes. For this purpose, we performed a phytochemical analysis to evaluate the plant's components. In the ...
Tópico(s): Environmental Toxicology and Ecotoxicology
2016 - Brazilian Academy of Sciences | Anais da Academia Brasileira de Ciências
Produção Nacional
Revisado por pares
Renata Cougo Moraes, Aline Jacobi Dalla Lana, Samuel Kaiser, Ânderson Ramos Carvalho, Luís Flávio Souza de Oliveira, Alexandre Meneghello Fuentefría, George González Ortega,
This study investigated in vitro antifungal activity of the hydroethanolic extract (EXT), quinovic acid glycosides (QAPF), oxindole alkaloids (OAPF), water-soluble (WSF) and insoluble fractions of polyphenols (WIF) obtained from Uncaria tomentosa bark against non-albicans Candida resistant isolates. Cytotoxicity and genotoxicity of the major fractions were also assayed. Growth inhibition was assayed by the broth microdilution method according to the CLSI M27-A3 guideline. The most active fractions were ...
Tópico(s): Traditional and Medicinal Uses of Annonaceae
2015 - Elsevier BV | Industrial Crops and Products
Produção Nacional
Revisado por pares
Bruna Pippi, Aline Jacobi Dalla Lana, Renata Cougo Moraes, Camila Martins Güez, Michel Mansur Machado, Luís Flávio Souza de Oliveira, Gilsane Lino von Poser, Alexandre Meneghello Fuentefría,
To evaluate the ability of Candida parapsilosis and Candida glabrata to develop phenotypic resistance to a benzophenone enriched fraction obtained from Brazilian red propolis (BZP-BRP) as compared to fluconazole (FLC). To investigate possible synergy between BZP-BRP and FLC and anidulafungin (AND).To analyse the development of resistance, isolates susceptible to these antifungals were cultured in increasing concentrations of FLC and BZP-BRP. The increase in FLC minimum inhibitory concentration for ...
Tópico(s): Phytochemistry Medicinal Plant Applications
2015 - Oxford University Press | Journal of Applied Microbiology
Produção Nacional
Revisado por pares
Daiane Flores Dalla Lana, Ricardo K. Donato, Cristiane Bündchen, Camila Martins Güez, Vanessa Zafaneli Bergamo, Luís Flávio Souza de Oliveira, Michel Mansur Machado, Henri Stephan Schrekker, Alexandre Meneghello Fuentefría,
To investigate the antidermatophytic action of a complementary set imidazolium salts (IMS), determining structure-activity relationships and characterizing the IMS toxicological profiles.The susceptibility evaluation of 45 dermatophytic clinical isolates, treated in vitro with eleven different IMS (ionic compounds) and commercial antifungals (nonionic compounds), was performed by broth microdilution, following the standard norm of CLSI M38-A2. All dermatophytes were inhibited by IMS, where the lowest ...
Tópico(s): Beetle Biology and Toxicology Studies
2015 - Oxford University Press | Journal of Applied Microbiology
Produção Nacional
Revisado por pares
Henri Stephan Schrekker, Ricardo K. Donato, Alexandre Meneghello Fuentefría, Vanessa Zafaneli Bergamo, Luís Flávio Souza de Oliveira, Michel Mansur Machado,
This study demonstrates the excellent in vitro antifungal activity profile of imidazolium ionic liquids (ILs) against species of opportunistic human mycoses. Several ILs were identified as more effective and less harmful than commercially available antifungal medications. Frequently, emerging yeast pathogens are resistant against commercial antifungal agents and, as a consequence, this class of imidazolium ILs represents a promising breakthrough in their treatment.
Tópico(s): Nanocomposite Films for Food Packaging
2013 - Royal Society of Chemistry | MedChemComm
Produção Nacional
Revisado por pares
Ana Maria Quilez, B. Berenguer, Gianluca Gilardoni, Caden Souccar, Sérgio Mendonça, Luís Flávio Souza de Oliveira, M.J. Martín-Calero, Giovanni Vidari,
The leaves of Piper carpunya Ruiz & Pav. (syn Piper lenticellosum C.D.C.) (Piperaceae), are widely used in folk medicine in tropical and subtropical countries of South America as an anti-inflammatory, anti-ulcer, anti-diarrheal and anti-parasitical remedy as well as an ailment for skin irritations. To study the anti-inflammatory, anti-secretory and anti-Helicobacter pylori activities of different fractions isolated from an ethanolic extract of the leaves of Piper carpunya, in order to provide evidence ...
Tópico(s): Phytochemistry and biological activities of Ficus species
2010 - Elsevier BV | Journal of Ethnopharmacology
Produção Nacional
Revisado por pares
Anna Brandt, Luís Flávio Souza de Oliveira, Franciele Bortoluzi Fernandes, J P Castanedo de Alba,
As doenças cardiovasculares (DC) estão, de modo geral, associadas a elevados níveis séricos de lipídeos, atingindo homens e mulheres, sem distinção de idade. Entre as propriedades atribuídas pela medicina popular à Vitex megapotamica (Spreng) Moldenke (V. montevidensis Cham) -Tarumã estão a de reduzir os níveis séricos de colesterol e triglicerídeo. O principal objetivo do presente estudo foi avaliar o potencial hipocolesterolêmico e hipolipidêmico da V. megapotamica, bem como fazer um estudo toxicológico ...
Tópico(s): Phytochemistry Medicinal Plant Applications
2009 - Springer Science+Business Media | Revista Brasileira de Farmacognosia
Produção Nacional
Revisado por pares
Rozangela Curi Pedrosa, Christiane Meyre‐Silva, Valdir Cechinel Filho, J. C. Benassi, Luís Flávio Souza de Oliveira, Vilmair Zancanaro, Jacir Dal Magro, Rosendo Augusto Yunes,
The lipid-lowering action of the leaves of the Aleurites moluccana methanol extract was studied in Triton W-1339 and high-fat-diet fed rats. The serum lipids (total cholesterol, LDL- and HDL-cholesterol and triglycerides) and body weight were found to be lowered by A. moluccana (300 mg/kg, b.w.) in rats with Triton-induced hypercholesterolaemia and on a hyperlipaemic diet. The results suggest that the lipid lowering action of this natural product is mediated through inhibition of hepatic cholesterol ...
Tópico(s): Phytochemistry and Biological Activities
2002 - Wiley | Phytotherapy Research
... fate in Spemann's organizer Flávio S.J. de Souza Flávio S.J. de Souza Division of Molecular Embryology, ... more papers by this author Flávio S.J. de Souza Flávio S.J. de Souza Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer ...
Tópico(s): Genomics and Chromatin Dynamics
1999 - Springer Nature | The EMBO Journal
Produção Nacional
Revisado por pares
Daiane Flores Dalla Lana, Laura Giuliani, Jéssica Brandão Reolon, William Lopes, Marilene Henning Vainstein, Letícia Jacobi Danielli, Vanessa Zafaneli Bergamo, Bruna Pippi, Miriam Anders Apel, Mário Lettieri Teixeira, Luís Flávio Souza de Oliveira, Michel Mansur Machado, Saulo Fernandes de Andrade, Marcus M. Sá, Misael Ferreira, Laiéli S. Munaretto, Letícia Cruz, Gustavo P. Silveira, Edilma Elayne, Alexandre Meneghello Fuentefría,
Abstract We report the antifungal and antichemotactic activities of a series of allylic thiocyanates with low toxicity. We also show improved antifungal activity of the most promising compound when used in a nanoemulsion (NE). The 4‐chlorophenyl‐substituted allylic thiocyanate (compound 11 ) exhibited a broad spectrum of antifungal activity and showed antichemotactic effects with 100% reduction in leucocyte migration. Minimal inhibitory concentrations ranged from 25 to 50 μg mL −1 , and the mechanism of ...
Tópico(s): Antimicrobial agents and applications
2018 - Wiley | ChemistrySelect
Produção Nacional
Revisado por pares
Gabriela C. Meirelles, Bruna Pippi, Camila Hatwig, Francisco Barros, Luís Flávio Souza de Oliveira, Gilsane Lino von Poser, Alexandre Meneghello Fuentefría,
Hypericum species, Hypericaceae, are recognized as a source of therapeutical agents. Purified fractions and isolated compounds have been shown antimicrobial activity. As the indiscriminate use of antifungals and the increase of infections caused by emerging species are leading to the search of new alternative treatments, the aim of this study was to continue the study with Hypericum carinatum Griseb. lipophilic fraction, rich in phloroglucinol derivatives, investigating the effect of its association ...
Tópico(s): Fungal Infections and Studies
2016 - Springer Science+Business Media | Revista Brasileira de Farmacognosia
Produção Nacional
Revisado por pares
Maria Fernanda de Moura Leão, Jonathaline Apollo Duarte, Patrícia Dutra Sauzen, Jacqueline da Costa Escobar Piccoli, Luís Flávio Souza de Oliveira, Michel Mansur Machado,
Hypertension, a chronic non-transmissible multifactorial condition, it is highly frequent in Brazil, affecting about 32.5% of the population over 25 years of age. It is characterized by the sustained increase in systolic and diastolic blood pressure levels above 140 mmHg and 90 mmHg, respectively. It is the major aggravating factor in cardiovascular complications and the appearance of other comorbidities. Aiming to promote greater adherence to treatment and improve the population's access to basic ...
Tópico(s): Effects and risks of endocrine disrupting chemicals
2018 - Elsevier BV | Environmental Toxicology and Pharmacology
Produção Nacional
Revisado por pares
Débora Regina Hoff Brait, Márcia Soares Mattos Vaz, Jucicléia da Silva Arrigo, Luciana Noia Borges de Carvalho, Flávio Henrique Souza de Araújo, Juliana Miron Vani, Jonas da Silva Mota, Cláudia Andréa Lima Cardoso, Rodrigo Juliano Oliveira, Fábio Juliano Negrão, Cândida Aparecida Leite Kassuya, Arielle Cristina Arena,
This study assessed the anti-inflammatory effects of the essential oil from Piper vicosanum leaves (OPV) and evaluated the toxicological potential of this oil through acute toxicity, genotoxicity and mutagenicity tests. The acute toxicity of OPV was evaluated following oral administration to female rats at a single dose of 2 g/kg b.w. To evaluate the genotoxic and mutagenic potential, male mice were divided into five groups: I: negative control; II: positive control; III: 500 mg/kg of OPV; IV: 1000 ...
Tópico(s): Ginger and Zingiberaceae research
2015 - Elsevier BV | Regulatory Toxicology and Pharmacology
Produção Nacional
Revisado por pares
Priscilla Maciel Quatrin, Daiane Flores Dalla Lana, Luana Candice Genz Bazana, Luís Flávio Souza de Oliveira, Mário Lettieri Teixeira, Edilma Elaine Silva, William Lopes, Rômulo Faria Santos Canto, Gustavo P. Silveira, Alexandre Meneghello Fuentefría,
The development of resistance to the current antifungal agents is an alarming problem.
Tópico(s): Redox biology and oxidative stress
2018 - Royal Society of Chemistry | New Journal of Chemistry
Produção Nacional
Revisado por pares
Camila Martins Güez, Emily Pansera Waczuk, Karina Braccini Pereira, Marcus Vinícius Morini Querol, João Batista Teixeira da Rocha, Luís Flávio Souza de Oliveira,
The use of plants as a source of palliative or cure for pathological conditions is quite common worldwide. Xanthium spinosum (Asteraceae), popularly known in Brazil as 'espinho de carneiro', is an annual weed from South America, which has been used by empiric medicine to treat neoplasias. Owing to the extensive use of the above-mentioned plant and to the lack of reports about the real effects of its infusion, current study evaluated the genotoxic potential of its aqueous extract at concentrations ...
Tópico(s): Weed Control and Herbicide Applications
2012 - UNIVERSIDADE DE SÃO PAULO | Brazilian Journal of Pharmaceutical Sciences
Produção Nacional
Revisado por pares
Éder Augusto de Lucena, A. M. O. Rebelo, Flávio Henrique Souza de Araújo, W. O. Sousa, Ana Letícia Almeida Dantas, Bernardo Maranhão Dantas, Rossana Corbo,
The manipulation of a wide variety of unsealed sources in Nuclear Medicine results in a significant risk of internal exposure of the workers. 131I should be highlighted among the most frequently used radionuclides because of its large application for diagnosis and therapy of thyroid diseases. The increasing use of radionuclides for medical purposes creates a demand for feasible methodologies to perform occupational control of internal contamination. Currently in Brazil, there are ∼300 nuclear medicine ...
Tópico(s): Radioactivity and Radon Measurements
2007 - Oxford University Press | Radiation Protection Dosimetry
Produção Nacional
Revisado por pares
Bernardo Maranhão Dantas, Éder Augusto de Lucena, Ana Letícia Almeida Dantas, Flávio Henrique Souza de Araújo, A. M. O. Rebelo, M. Teran, Andrea Paolino, Juan C. Hermida, Ana Rojo, J. A. Puerta, Javier Morales, Gladys M. López Bejerano, Mario Alfaro, Montero Ruiz, R. Videla, O. Pinones, S. Gonzalez, T. Navarro, Dunstanta R. Melo, R. Cruz-Suarez,
The concern about accidents involving radioactive materials has led to the search of alternative methods to quickly identify and quantify radionuclides in workers and in the population. One of the options to face up an eventual demand for mass monitoring of internal contamination is the use of a nuclear medicine diagnostic equipment known as gamma camera, a device used to scan patients who have been administered specific amounts of radioactive materials for medical purposes. Although the gamma camera ...
Tópico(s): Nuclear Physics and Applications
2007 - Oxford University Press | Radiation Protection Dosimetry
Produção Nacional
Revisado por pares
Fernando Freitas de Lima, Sara Emília Lima Tolouei, Giseli Karenina Traesel, Flávio Henrique Souza de Araújo, Caroline Honaiser Lescano, Sara Moraes Peixoto, Felipe Ariel Mao Silva, Silvia Cristina Heredia Vieira, Maria do Carmo Vieira, Silvia Aparecida Oesterreich,
Attalea phalerata Mart. ex Spreng. (Arecaceae), popularly known as "bacuri", is used in Brazilian folk medicine. Its oil is used orally to relieve pulmonary congestion and joint pain. In topical applications, it is applied as an effective hair tonic and anti-dandruff. The in natura pulp and its nuts are used as food because of its nutritional value. Despite its use in folk medicine, there is a lack of data regarding its in vivo/in vitro cytotoxic/genotoxic and clastogenic effects. Therefore, in this ...
Tópico(s): Pesticide Exposure and Toxicity
2016 - Public Library of Science | PLoS ONE
Fabiana G. Marcondes‐Braga, Lídia Zytynski Moura, Victor Sarli Issa, Jefferson L. Vieira, Luís Eduardo Paim Rohde, Marcus Vinı́cius Simões, Miguel Morita Fernandes-Silva, Salvador Rassi, Sílvia Marinho Martins Alves, Denílson Campos de Albuquerque, Dirceu Rodrigues Almeida, Edimar Alcides Bocchi, Felix José Alvarez Ramires, Fernando Bacal, João Manoel Rossi Neto, Luiz Cláudio Danzmann, Marcelo Westerlund Montera, Múcio Tavares de Oliveira, Nadine Clausell, Odílson Marcos Silvestre, Reinaldo B. Bestetti, Sabrina Bernadez-Pereira, Aguinaldo Figueiredo Freitas, Andréia Biolo, Antônio Carlos Pereira Barretto, Antônio José Lagoeiro Jorge, Bruno Biselli, Carlos Eduardo Lucena Montenegro, Edval Gomes dos Santos, Estêvão Lanna Figueiredo, Fábio Fernandes, Fábio Serra Silveira, Fernando Antibas Atik, Flávio de Souza Brito, Germano Emílio Conceição Souza, Gustavo Calado de Aguiar Ribeiro, Humberto Villacorta, João David de Souza, Lívia Adams Goldraich, Luís Beck da Silva Neto, Manoel Fernandes Canesin, Marcelo Imbroinise Bittencourt, Marcely Gimenes Bonatto, Maria da Consolação Vieira Moreira, Mônica Samuel Ávila, Otávio R. Coelho‐Filho, Pedro Vellosa Schwartzmann, Ricardo Mourilhe‐Rocha, Sandrigo Mangini, Silvia Moreira Ayub‐Ferreira, José A. Figueiredo, Evandro Tinoco Mesquita,
Introdução A última Diretriz de Insuficiência Cardíaca do Departamento de Insuficiência Cardíaca da Sociedade Brasileira de Cardiologia (DEIC/SBC) foi finalizada em março de 2018. A partir de então, houve um importante número de intervenções terapêuticas e abordagens diagnósticas que surgiram ou se consolidaram na prática clínica internacional e na pesquisa clínica. Ao lado disso, a pandemia da COVID-19 trouxe-nos conhecimento sobre o modelo fisiopatológico da agressão miocárdica e muitas dúvidas ...
Tópico(s): Cardiac Structural Anomalies and Repair
2021 - Sociedade Brasileira de Cardiologia (SBC) | Arquivos Brasileiros de Cardiologia
Produção Nacional
Revisado por pares
Lorena Andrade Nunes, Rafaelle Piazzaroli Finotti, Flávio de Souza Barbosa, Alexandre Cury,
Over the past decades, several methods for structural health monitoring have been developed and employed in various practical applications. Some of these techniques aimed to use raw dynamic measurements to detect damage or structural changes. Desirably, structural health monitoring systems should rely on computational tools capable of evaluating the information acquired from the structure continuously, in real time. However, most damage detection techniques fail to identify novelties automatically ( ...
Tópico(s): Concrete Corrosion and Durability
2020 - SAGE Publishing | Structural Health Monitoring