Produção Nacional
Revisado por pares
Paulo Roberto Campos Flexa Ribeiro Filho, Matheus Rocha do Nascimento, Silvia Shelly Otaviano da Silva, F. Murilo T. Luna, Enrique Rodrı́guez-Castellón, Célio L. Cavalcante,
The depletion of oil reserves and concerns about the environmental impact of the use and incorrect disposal of mineral lubricants have been promoting the development of bio-based lubricants. In this study, biolubricants obtained from fatty acids of castor oil were synthesized by esterification (>wt.%93), epoxidation (>wt.%92), and oxirane ring opening reactions using water (>wt.%92) or 2-ethylhexanol (>wt.%94) as nucleophilic agents. The frictional characteristics of the synthesized samples were obtained ...
Tópico(s): Biodiesel Production and Applications
2023 - Multidisciplinary Digital Publishing Institute | Lubricants
Produção Nacional
Revisado por pares
Nathália Carolina Fernandes Fagundes, Nicole Melres Rabello, Lucianne Cople Maia, David Normando, Karina Corrêa Flexa Ribeiro Mello,
ABSTRACT Objective: To evaluate whether the use of palatal expansion techniques can influence hearing loss in children and adolescents with previous hearing impairment. Materials and Methods: Electronic searches in PubMed, Scopus, Web of Science, The Cochrane Library, Lilacs, OpenGrey, and Google Scholar were performed with a controlled vocabulary and free-text terms relating to palatal expansion and hearing loss. No language or time restrictions were imposed. Clinical trials that focused on human ...
Tópico(s): Craniofacial Disorders and Treatments
2017 - E.H Angle Education and Research Foundation | The Angle Orthodontist
Produção Nacional
Suelem Izumi, Fernando Flexa Ribeiro‐Filho, Gláucia Carneiro, Sônia Maria Togeiro, Sérgio Tufik, Maria Teresa Zanella,
This study examined insulin-like growth factor-1 (IGF-1) production and its association with the metabolic syndrome (MS) in men with obstructive sleep apnea (OSA).
Tópico(s): Neuroscience of respiration and sleep
2016 - American Academy of Sleep Medicine | Journal of Clinical Sleep Medicine
Produção Nacional
Revisado por pares
Bianca de Almeida-Pititto, Fernando Flexa Ribeiro‐Filho, Itamar S Santos, Paulo A. Lotufo, Isabela M. Benseñor, Sandra Roberta G. Ferreira,
Objective The study assessed the association of adiponectin concentration with carotid intima-media thickness (CIMT) in middle-aged participants of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) without diabetes or cardiovascular disease. Design Cross-sectional analyses. Methods A sample of 687 individuals (35-54 years old) without diabetes or cardiovascular disease was stratified into two categories according to CIMT (< or ≥ 75th percentile). Traditional risk factors, C-reactive protein ...
Tópico(s): Cardiovascular Health and Disease Prevention
2016 - Oxford University Press | European Journal of Preventive Cardiology
Produção Nacional
Revisado por pares
Bianca de Almeida-Pititto, Fernando Flexa Ribeiro‐Filho, Márcio Sommer Bittencourt, Paulo A. Lotufo, Isabela M. Benseñor, Sandra Roberta G. Ferreira,
This cross-sectional analysis evaluated whether determination of E-selectin concentrations could identify deterioration of cardiometabolic risk profile or subclinical atherosclerosis in individuals at low-to-moderate risk included in The Brazilian Longitudinal Study of Adult Health—ELSA-Brasil. A sample of 984 individuals from ELSA-Brasil (35–54 years) without cardiovascular disease or diabetes was stratified according to E-selectin tertiles. Traditional risk factors, inflammatory markers and categories ...
Tópico(s): Cell Adhesion Molecules Research
2016 - BioMed Central | Diabetology & Metabolic Syndrome
Produção Nacional
Revisado por pares
Aline do Carmo Bastos, Joelma Bezerra de Oliveira, Karina Flexa Ribeiro Mello, Patrícia Botelho Leão, Flávia Artese, David Normando,
The aim of this study was to evaluate the ability of oral/maxillofacial surgeons (OMFSs) and orthodontists to predict third molar eruption by examining a simple panoramic radiograph in cases where full spontaneous eruption occurred.Panoramic radiographs of 17 patients, 13-16 years of age, were obtained just after orthodontic treatment (T1), when the third molars were intraosseous. The radiographs at T1 were presented to 28 OMFSs and 28 orthodontists-who were asked to give a prognosis for the lower ...
Tópico(s): Oral and Maxillofacial Pathology
2016 - Springer Nature | Progress in Orthodontics
Produção Nacional
Revisado por pares
Sônia Maria Togeiro, Gláucia Carneiro, Fernando Flexa Ribeiro Filho, Maria Teresa Zanella, Rogério Santos‐Silva, Jose Augusto Taddei, Lia Bittencourt, Sérgio Tufik,
Abstract Objective: Epidemiologic studies that control for potential confounders are needed to assess the independent associations of obstructive sleep apnea (OSA) with metabolic abnormalities. The aim of our study was to evaluate the associations of OSA with metabolic abnormalities among the adult population of Sao Paulo, Brazil. Design and Methods: Questionnaires were applied face‐to‐face, full night polysomnography (PSG) was performed, and blood samples were collected in a population‐based survey ...
Tópico(s): Sleep and related disorders
2013 - Wiley | Obesity
Sônia Maria Togeiro, Gláucia Carneiro, Fernando Flexa Ribeiro Filho, Maria Teresa Zanella, Rogério Santos‐Silva, Jose Augusto Taddei, Lia Bittencourt, Sérgio Tufik,
Tópico(s): Regulation of Appetite and Obesity
2012 - Wiley | Obesity
Produção Nacional
Revisado por pares
Gláucia Carneiro, R. Florio, Maria Teresa Zanella, Márcia Pradella-Hallinan, Fernando Flexa Ribeiro‐Filho, Sérgio Tufik, Sônia Maria Togeiro,
Tópico(s): Dysphagia Assessment and Management
2011 - Springer Science+Business Media | Sleep And Breathing
Produção Nacional
Maria Teresa Zanella, Fernando Flexa Ribeiro Filho,
Central obesity have an important impact on the development of risk factors for coronary heart disease, including dislipidemia, glucose intolerance, insulin resistance and hypertension. These factors contribute to building cardiovascular (CV) disease as a major cause of death. The approach to obesity therapy should be designed to reduce CV risk and mortality. Diet and lifestyle changes remain the cornerstones of therapy for obesity, but the resultant weight loss is often small and long-term success ...
Tópico(s): Neurotransmitter Receptor Influence on Behavior
2009 - Editora da Universidade de São Paulo | Arquivos Brasileiros de Endocrinologia & Metabologia
Produção Nacional
Revisado por pares
Gláucia Carneiro, Sônia Maria Togeiro, Fernando Flexa Ribeiro‐Filho, Eveli Truksinas, Artur Beltrame Ribeiro, Maria Teresa Zanella, Sérgio Tufik,
Background: Obstructive sleep apnea (OSA) is associated with several conditions that could facilitate the onset of cardiovascular and metabolic dysfunctions. Continuous positive airway pressure (CPAP) therapy has been shown to improve cardiovascular morbidity and mortality related to OSA, but the mechanisms underlying this association are not fully understood. Objective: The aim of the present study was to evaluate whether sleep apnea contributes to insulin resistance and inflammatory marker alterations ...
Tópico(s): Inflammatory Biomarkers in Disease Prognosis
2009 - Mary Ann Liebert, Inc. | Metabolic Syndrome and Related Disorders
Produção Nacional
Revisado por pares
L Mariosa, Fernando Flexa Ribeiro‐Filho, Marcelo Costa Batista, Andréa H. Hirota, Rodolfo Leão Borges, Artur Beltrame Ribeiro, Maria Teresa Zanella,
The activation of the renin‐angiotensin system (RAS) is an important mechanism that contributes to hypertension in obese individuals. Thiazide diuretics also activate the RAS in response to volume contraction and can lead to a decrease in serum potassium values and glucose metabolism abnormalities. To evaluate the impact of abdominal obesity on potassium depletion and glucose homeostasis in hypertensive patients receiving thiazide therapy, the authors studied 329 hypertensive patients without known ...
Tópico(s): Electrolyte and hormonal disorders
2008 - Wiley | Journal of Clinical Hypertension
Produção Nacional
Revisado por pares
Gláucia Carneiro, Sônia Maria Togeiro, Lilian Fukusima Hayashi, Fernando Flexa Ribeiro‐Filho, Artur Beltrame Ribeiro, Sérgio Tufik, Maria Teresa Zanella,
Obstructive sleep apnea syndrome (OSAS) increases the risk of cardiovascular events. Sympathetic nervous system and hypothalamic-pituitary-adrenal (HPA) axis activation may be the mechanism of this relationship. The aim of this study was to evaluate HPA axis and ambulatory blood pressure monitoring in obese men with and without OSAS and to determine whether nasal continuous positive airway pressure therapy (nCPAP) influenced responses. Twenty-four-hour ambulatory blood pressure monitoring and overnight ...
Tópico(s): Asthma and respiratory diseases
2008 - American Physiological Society | AJP Endocrinology and Metabolism
Produção Nacional
Revisado por pares
Rodolfo Leão Borges, Fernando Flexa Ribeiro‐Filho, Kênia Mara Baiocchi de Carvalho, Maria Teresa Zanella,
OBJETIVO: Avaliar o impacto do tratamento da obesidade nas adipocitocinas, na proteína C-reativa (PCR) e na sensibilidade à insulina em pacientes hipertensas com obesidade central. MÉTODOS: O estudo foi realizado a partir do banco de dados e de amostras estocadas de soro de pacientes submetidas previamente a um estudo para tratamento de obesidade. Foram selecionadas 30 mulheres hipertensas, com idade entre 18 e 65 anos, índice de massa corpórea (IMC) > 27 kg/m², com distribuição central de gordura. ...
Tópico(s): Healthcare Regulation
2007 - Sociedade Brasileira de Cardiologia (SBC) | Arquivos Brasileiros de Cardiologia
Produção Nacional
Caroline Bulc o, Fernando Flexa Ribeiro‐Filho, A. Udo, Sandra Roberta G. Ferreira,
Tópico(s): Lipid metabolism and disorders
2007 - Adis, Springer Healthcare | American Journal of Cardiovascular Drugs
Produção Nacional
Revisado por pares
Caroline Bulcão, Sandra Roberta G. Ferreira, Fernando M. A. Giuffrida, Fernando Flexa Ribeiro‐Filho,
Obesity is a well-known risk factor for the development of insulin resistance, type 2 diabetes, dyslipidemia, hypertension, and cardiovascular disease. Rather than the total amount of fat, central distribution of adipose tissue is very important in the pathophysiology of this constellation of abnormalities termed metabolic syndrome. Adipose tissue, regarded only as an energy storage organ until the last decade, is now known as the biggest endocrine organ of the human body. This tissue secretes a ...
Tópico(s): Adipokines, Inflammation, and Metabolic Diseases
2006 - Bentham Science Publishers | Current Diabetes Reviews
Produção Nacional
Fernando Flexa Ribeiro Filho, Lydia S. Mariosa, Sandra Roberta G. Ferreira, Maria Teresa Zanella,
A síndrome metabólica (SM) é vista atualmente como uma epidemia mundial, com números alarmantes, associada a alta morbi-mortalidade cardiovascular e elevado custo sócio-econômico. O ganho ponderal é preditor independente para o desenvolvimento da SM, embora nem todos os indivíduos obesos a apresentem. Por outro lado, certas populações com baixa prevalência de obesidade apresentam elevada prevalência da SM e mortalidade cardiovascular. A distribuição da gordura corporal é relevante, e especificamente ...
Tópico(s): Metabolism, Diabetes, and Cancer
2006 - Editora da Universidade de São Paulo | Arquivos Brasileiros de Endocrinologia & Metabologia
Produção Nacional
Alessandra N. Faria, Fernando Flexa Ribeiro Filho, Nárcia E. B. Kohlmann, Sandra Roberta G. Ferreira, Maria Teresa Zanella,
Objective: The objective of this study is to assess the effects of sibutramine on body weight, body fat distribution, insulin resistance, plasma leptin, lipid profile and blood pressure profiles in hypertensive obese patients. Methods: Eighty‐six central obese hypertensive patients (BMI = 39 ± 5 kg/m 2 , 84% of women, 48 ± 8.5 years old) were placed on a hypocaloric diet and placebo therapy for 4 weeks. They were then randomized to receive sibutramine (10 mg) or placebo for 24 weeks. Both, before therapy ...
Tópico(s): Muscle metabolism and nutrition
2005 - Wiley | Diabetes Obesity and Metabolism
Produção Nacional
Revisado por pares
Gláucia Carneiro, Alessandra N. Faria, Fernando Flexa Ribeiro Filho, Adriana Coutinho de Azevedo Guimarães, Daniel D G Lerario, Sandra Roberta G. Ferreira, Maria Teresa Zanella,
Obese people are at higher cardiovascular risk than people with normal body weight. The objective of this study was to establish the relationship between obesity, body fat distribution and cardiovascular risk factors.Body mass index (BMI), waist-hip ratio (WHR) systolic (SBP) and diastolic blood pressure (DBP), plasma cholesterol, triglycerides and glucose levels were determined in a population of 499 overweight and obese patients (432F/67M; age 39 12.9y).High prevalence of abnormal glucose tolerance ...
Tópico(s): Healthcare Regulation
2003 - Brazilian Medical Association | Revista da Associação Médica Brasileira
Produção Nacional
Fernando Flexa Ribeiro‐Filho, Alessandra N. Faria, Sergio Azjen, Maria Teresa Zanella, Sandra Roberta G. Ferreira,
Abstract Objective : To compare methods for the assessment of visceral fat with computed tomography (CT) and establish cutoffs to define visceral obesity based on such alternative methods. Research Methods and Procedures : One hundred women (50.4 ± 7.7 years; BMI 39.2 ± 5.4 kg/m 2 ) underwent anthropometric evaluation, bioelectrical impedance, DXA, abdominal ultrasonography (US), and CT scan. Results : Waist circumference, waist‐to‐hip ratio (WHR), and US‐determined visceral fat values showed the best correlation ...
Tópico(s): Cardiovascular Disease and Adiposity
2003 - Wiley | Obesity Research
Produção Nacional
Revisado por pares
Fernando Flexa Ribeiro‐Filho, Alessandra N. Faria, Nárcia E. B. Kohlmann, Maria Teresa Zanella, Sandra Roberta G. Ferreira,
OBJECTIVE—Visceral obesity is shown to be a predictor of morbidity and mortality. We evaluated the association of measurements of generalized adiposity and visceral fat area (VFA), with abnormalities of metabolic syndrome (MS). RESEARCH DESIGN AND METHODS—Seventy-six women (47.9 ± 9.2 years) with BMI of 38.7 ± 5.4 kg/m2 underwent anthropometric measurements, laboratory procedures, bioeletrical impedance, and abdominal computed tomography (CT) scan. Diagnosis of MS was based on the presence of abdominal ...
Tópico(s): Adipokines, Inflammation, and Metabolic Diseases
2003 - American Diabetes Association | Diabetes Care
Produção Nacional
Alessandra N. Faria, Fernando Flexa Ribeiro Filho, Sandra Roberta G. Ferreira, Maria Teresa Zanella,
Abstract Objective: The relationship among body fat distribution, blood pressure, serum leptin levels, and insulin resistance was investigated in hypertensive obese women with central distribution of fat. Research Methods and Procedures: We studied 74 hypertensive women (age, 49.8 ± 7.5 years; body mass index, 39.1 ± 5.5 kg/m 2 ; waist‐to‐hip ratio, 0.96 ± 0.08). All patients were submitted to 24‐hour blood pressure ambulatory monitoring (24h‐ABPM). Abdominal ultrasonography was used to estimate the amount ...
Tópico(s): Cardiovascular Disease and Adiposity
2002 - Wiley | Obesity Research
Produção Nacional
Revisado por pares
Alessandra N. Faria, Fernando Flexa Ribeiro Filho, Daniel D G Lerario, Nárcia E. B. Kohlmann, Sandra Roberta G. Ferreira, Maria Teresa Zanella,
OBJECTIVE: To assess the effects of weight reduction with 10mg of sibutramine or placebo on blood pressure during 24 hours (ambulatory blood pressure monitoring), on left ventricular mass, and on antihypertensive therapy in 86 obese and hypertensive patients for 6 months. METHODS: The patients underwent echocardiography, ambulatory blood pressure monitoring, and measurement of the levels of hepatic enzymes prior to and after treatment with sibutramine or placebo. RESULTS: The group using sibutramine ...
Tópico(s): Cardiovascular Syncope and Autonomic Disorders
2002 - Sociedade Brasileira de Cardiologia (SBC) | Arquivos Brasileiros de Cardiologia
Produção Nacional
Revisado por pares
Eduardo Cantoni Rosa, Valdir Ambrósio Moysés, Ricardo Sesso, Frida Liane Plavnik, Fernando Flexa Ribeiro, Nárcia E. B. Kohlmann, Artur Beltrame Ribeiro, Maria Teresa Zanella, Osvaldo Kohlmann,
PURPOSE: To evaluate left ventricular mass (LVM) index in hypertensive and normotensive obese individuals. METHODS: Using M mode echocardiography, 544 essential hypertensive and 106 normotensive patients were evaluated, and LVM was indexed for body surface area (LVM/BSA) and for height² (LVM/h²). The 2 indexes were then compared in both populations, in subgroups stratified according to body mass index (BMI): or = 30kg/m². RESULTS: The BSA index does not allow identification of significant differences ...
Tópico(s): Cardiovascular Disease and Adiposity
2002 - Sociedade Brasileira de Cardiologia (SBC) | Arquivos Brasileiros de Cardiologia
Produção Nacional
Revisado por pares
Fernando Flexa Ribeiro‐Filho, Alessandra N. Faria, Oswaldo Kohlmann, Sérgio Ajzen, Artur Beltrame Ribeiro, Maria Teresa Zanella, Sandra Roberta G. Ferreira,
Abstract — —Visceral fat accumulation is associated with increased cardiovascular risk. Clinical evaluation of visceral fat is limited because of the lack of reliable and low-cost methods. To assess the correlation between ultrasonography and computed tomography (CT) for the evaluation of visceral fat, 101 obese women, age 50.5±7.7 years with a body mass index of 39.2±5.4 kg/m 2 , were submitted to ultrasonograph and CT scans. Visceral fat measured by ultrasonography, 1 cm above the umbilical knot, showed ...
Tópico(s): Adipokines, Inflammation, and Metabolic Diseases
2001 - Lippincott Williams & Wilkins | Hypertension
Produção Nacional
Revisado por pares
Bianca de Almeida-Pititto, Fernando Flexa Ribeiro‐Filho, Paulo A. Lotufo, Isabela M. Benseñor, Sandra Roberta G. Ferreira,
Abnormal glucose metabolism preceding overt diabetes is associated with increased cardiovascular risk. Whether novel biomarkers are useful to identify this condition is unclear. The objective was to investigate associations of biomarkers of atherogenesis with plasma glucose within non-diabetic range. 998 participants (35-54 years) of the Brazilian Longitudinal Study of Adult Health without diabetes or cardiovascular disease were classified as normal glucose tolerance (NGT), impaired fasting glycemia ( ...
Tópico(s): Clusterin in disease pathology
2015 - Elsevier BV | Diabetes Research and Clinical Practice
Produção Nacional
Gláucia Carneiro, Fernando Flexa Ribeiro Filho, Sônia Maria Togeiro, Sérgio Tufik, Maria Teresa Zanella,
Estudos anteriores mostraram que pacientes com Apnéia Obstrutiva do Sono (AOS) apresentam maior risco para doenças cardiovasculares. Entretanto, permanece controverso se essa associação depende da obesidade ou se ocorre devido a alterações fisiológicas decorrentes da desordem do sono, como ativação do sistema nervoso simpático, da inflamação e desordens do eixo corticotrófico e somatotrófico, que predispõem a danos vasculares. Além disso, muitos fatores de risco para doenças cardiovasculares (DCV) ...
Tópico(s): Sleep and related disorders
2007 - Editora da Universidade de São Paulo | Arquivos Brasileiros de Endocrinologia & Metabologia
Produção Nacional
Revisado por pares
Bianca de Almeida-Pititto, Suely G.A. Gimeno, Renata Damião, Fernando Flexa Ribeiro‐Filho, Sandra Roberta G. Ferreira,
We evaluated the relationship of leptin with hypertension adjusted for body mass index (BMI) and/or waist circumference in a population of Japanese-Brazilian women aged > or = 30 years with centrally distributed adiposity. After excluding diabetic subjects, the study subjects--who participated in a population-based study on the prevalence of metabolic syndrome--showed prevalence rates of obesity (BMI > or = 25 kg/m2) and central adiposity (waist > or = 80 cm) of 32.0 and 37.8%, respectively. The hypertensive group ( ...
Tópico(s): Biochemical Analysis and Sensing Techniques
2006 - Associação Brasileira de Divulgação Científica | Brazilian Journal of Medical and Biological Research
Produção Nacional
Revisado por pares
Narjara Condurú Fernandes da Silva, Éllida Renata Barroso de Aquino, Karina Corrêa Flexa Ribeiro Mello, José Nazareno Rufino de Mattos, David Normando,
OBJETIVO: analisar a habilidade de ortodontistas e leigos para perceber as assimetrias faciais causadas por desvios mandibulares. MÉTODOS: foram obtidas fotografias frontais da face de dois indivíduos, sendo um do sexo masculino e outro do sexo feminino. As fotografias foram tiradas em Posição Natural de Cabeça (PNC) com desvios mandibulares progressivos - em 2, 4 e 6mm -, partindo-se da posição de Máxima Intercuspidação Habitual (MIH). Para testar a reprodutibilidade do método, utilizaram-se os Coeficientes ...
Tópico(s): Facial Rejuvenation and Surgery Techniques
2011 - Dental Press Editora | Dental Press Journal of Orthodontics
Produção Nacional
Paulo Roberto Campos Flexa Ribeiro Filho, Silvia Shelly Otaviano da Silva, Matheus Rocha do Nascimento, Sandra de Aguiar Soares, F. Murilo T. Luna, Célio L. Cavalcante,
Tópico(s): Tribology and Wear Analysis
2022 - Springer Science+Business Media | Journal of the Brazilian Society of Mechanical Sciences and Engineering