Mǎng Shī, Xian-Dan Lin, Nikos Vasilakis, Jun-Hua Tian, Cixiu Li, Liang-Jun Chen, Gillian Eastwood, Xiu-Nian Diao, Ming‐Hui Chen, Xiao Chen, Xin-Cheng Qin, Steven G. Widen, Thomas G. Wood, Robert B. Tesh, Jianguo Xu, Edward C. Holmes, Yǒng-Zhèn Zhāng,
Viruses of the family Flaviviridae are important pathogens of humans and other animals and are currently classified into four genera. To better understand their diversity, ... to search for the viruses related to the Flaviviridae in a range of potential invertebrate and vertebrate ... jingmenviruses and 12 distant relatives of the known Flaviviridae ("flavi-like" viruses) from a range of arthropod ... similar genomic plan and common ancestry with the Flaviviridae in the NS3 and NS5 regions. Remarkably, although ...
Tópico(s): Insect symbiosis and bacterial influences
2015 - American Society for Microbiology | Journal of Virology
Juan Guevara, Nagindra Prashad, Boris S. Ermolinsky, John W. Gaubatz, Dongcheul Kang, Andrea E. Schwarzbach, David S. Loose, Juan Guevara,
... DNA binding domains of Interferon Regulatory Factors and Flaviviridae capsid/core proteins. It also contains a close ... herpesvirus 5 immediate-early transcriptional regulator (UL122) and Flaviviridae NS3 helicases. Region 2 peptides, B2-1 (3313Asp- ... the apo B100, and suggest a basis for Flaviviridae cell entry. LDL mediates transfection with plasmid DNA ... DNA binding domains of Interferon Regulatory Factors and Flaviviridae capsid/core proteins. It also contains a close ... herpesvirus 5 immediate-early transcriptional regulator (UL122) and Flaviviridae NS3 helicases. Region 2 peptides, B2-1 (3313Asp- ...
Tópico(s): interferon and immune responses
2010 - Elsevier BV | Journal of Lipid Research
Produção Nacional
Revisado por pares
Francisco Pereira Lobo, Bruno Eduardo Fernandes Mota, Sérgio D.J. Pena, Vasco Azevedo, Andréa Mara Macedo, Andreas Tauch, Carlos Renato Machado, Glória Regina Franco,
... both host immune system and viral escape mechanisms. Flaviviridae family is composed of fast evolving RNA viruses ... anti-viral mechanisms are likely to have evolved. Flaviviridae viruses which infect a single host lineage would ... work we compare the genomic evolutionary patterns of Flaviviridae viruses and their hosts in an attempt to ... vertebrate and invertebrate organisms as well as in Flaviviridae viruses which specifically infect one or both host ... group displayed only a TpA frequency reduction bias. Flaviviridae viruses mimicked host nucleotide motif usage in a ...
Tópico(s): Viral Infections and Vectors
2009 - Public Library of Science | PLoS ONE
Huipeng Yao, Mengyu Chen, Zizhong Tang,
Background . Flaviviridae viruses are single-stranded, positive-sense RNA viruses, which threat human constantly mediated by mosquitoes, ticks, and ... data to develop the medications for most of Flaviviridae viruses. Results . The overall extent of codon usage bias in 65 Flaviviridae viruses is low with the average value of ... lowest value is 40.2%. ENC values of Flaviviridae virus genes vary from 48.75 to 57. ... and A-ended codons are preferred in the Flaviviridae virus. Correlation analysis shows that the positive correlation ...
Tópico(s): RNA and protein synthesis mechanisms
2019 - Hindawi Publishing Corporation | BioMed Research International
Tomokazu Tamura, Takasuke Fukuhara, Takuro Uchida, Chikako Ono, Hiroyuki Mori, Asuka Sato, Yuzy Fauzyah, Toru Okamoto, Takeshi Kurosu, Yin Xiang Setoh, Michio Imamura, Norbert Tautz, Yoshihiro Sakoda, Alexander A. Khromykh, Kazuaki Chayama, Yoshiharu Matsuura,
ABSTRACT The family Flaviviridae consists of four genera, Flavivirus , Pestivirus , Pegivirus , and Hepacivirus , and comprises important pathogens of human and animals. Although the ... from NanoLuc luciferase to the engineering of the Flaviviridae viruses and then examined the biological characteristics of ... Taken together, our findings indicate that the recombinant Flaviviridae viruses possessing the split NanoLuc luciferase gene generated ... a robust platform to develop novel antivirals against Flaviviridae viruses. IMPORTANCE The construction of reporter viruses possessing ...
Tópico(s): Viral Infections and Vectors
2017 - American Society for Microbiology | Journal of Virology
Keke Wu, Shuangqi Fan, Linke Zou, Feifan Zhao, Shengming Ma, Jindai Fan, Xiaowen Li, Mingqiu Zhao, Hui‐chao Yan, He Zhang,
Diseases caused by Flaviviridae have a wide global and economic impact due to high morbidity and mortality. Flaviviridae infection usually leads to severe, acute or chronic ... virus (DENV). Given the highly complex pathogenesis of Flaviviridae infections, they are still not fully understood at ... is disrupted to regulate the life cycle of Flaviviridae. Organelle-specific autophagy is able to selectively target ... we briefly understand the LDs interaction relationship with Flaviviridae infection, outline the molecular events of how lipophagy ...
Tópico(s): HIV Research and Treatment
2021 - Frontiers Media | Frontiers in Microbiology
Shun Chen, Chao Yang, Wei Zhang, Suresh Mahalingam, Mingshu Wang, Anchun Cheng,
Infections with viruses in the Flaviviridae family have a vast global and economic impact because of the high morbidity and mortality. The pathogenesis of Flaviviridae infections is very complex and not fully understood ... non-structural (NS) 5 and 5A proteins of Flaviviridae viruses are highly conserved and play an important ... used by the NS5 and 5A proteins of Flaviviridae viruses for evading the innate immune response by ... for the discovery of broad spectrum compounds against Flaviviridae virus infection. The methyltransferase (MTase) and RNA-dependent ...
Tópico(s): interferon and immune responses
2018 - Elsevier BV | Pharmacology & Therapeutics
Ran Wang, Xinyu Wang, Linlin Zhang, Guoshuang Feng, Mengjia Liu, Yueping Zeng, Zhengde Xie,
Background Viruses of the family Flaviviridae , including Japanese encephalitis virus (JEV), dengue virus (DENV), yellow fever virus (YFV) and hepatitis C virus (HCV), are widely distributed worldwide. ... epidemiology and disease burden of children hospitalized for Flaviviridae virus infections between December 2015 and December 2020 ... aged 0–15 years hospitalized for infections with Flaviviridae viruses. Japanese encephalitis (JE) cases are the highest, ... 65% of the total hospitalization cases caused by Flaviviridae virus infection. The incidence of JE peaked from ...
Tópico(s): Malaria Research and Control
2022 - Public Library of Science | PLoS neglected tropical diseases
Geon‐Woo Kim, Hasan Imam, Mohsin Khan, Aleem Siddiqui,
... diverse viruses that belong to the Hepadnaviridae and Flaviviridae families, respectively, but share common pathologies (1Seeger C. ... Evans M.J. et al.N6-Methyladenosine in flaviviridae viral RNA genomes regulates infection.Cell Host Microbe. ... Evans M.J. et al.N6-Methyladenosine in flaviviridae viral RNA genomes regulates infection.Cell Host Microbe. ... Evans M.J. et al.N6-Methyladenosine in flaviviridae viral RNA genomes regulates infection.Cell Host Microbe. ... Evans M.J. et al.N6-Methyladenosine in flaviviridae viral RNA genomes regulates infection.Cell Host Microbe. ...
Tópico(s): interferon and immune responses
2020 - Elsevier BV | Journal of Biological Chemistry
Produção Nacional
Revisado por pares
Michele I. Morris, Paolo Grossi, Maurício Lacerda Nogueira, Luiz Sérgio Azevedo,
... of IgM and/or by RT-PCR. Previous Flaviviridae infections and previous Yellow Fever (YF) or Japanese ... high level of cross-reactive antibodies produced during Flaviviridae infections. Furthermore, there is an anamnestic response during ... by the YF virus, the prototype of the Flaviviridae family and Flavivirus genus. Several other important viruses ... or blood transfusion would appear likely, like other Flaviviridae, such as West Nile virus. To the best ... to the high immunological cross-reactivity between the Flaviviridae species, and confirmatory diagnosis is based on laboratory ...
Tópico(s): Viral Infections and Outbreaks Research
2018 - Wolters Kluwer | Transplantation
Shun Chen, Zhen Wu, Mingshu Wang, Anchun Cheng,
Flaviviridae-caused diseases are a critical, emerging public health problem worldwide. Flaviviridae infections usually cause severe, acute or chronic diseases, ... researchers worldwide are investigating the mechanisms by which Flaviviridae cause severe diseases. Flaviviridae can interfere with the host’s innate immunity ... review discusses the interplay between viral non-structural Flaviviridae proteins and relevant host proteins, which leads to ...
Tópico(s): Viral Infections and Vectors
2017 - Multidisciplinary Digital Publishing Institute | Viruses
Hélène Malet, Marie-Pierre Egloff, Barbara Selisko, R.E. Butcher, P.J. Wright, Michael M. Roberts, Arnaud Gruez, G. Sulzenbacher, Clemens Vonrhein, G. Bricogne, Jason M. Mackenzie, Alexander A. Khromykh, Andrew D. Davidson, Bruno Canard,
Viruses of the family Flaviviridae are important human and animal pathogens. Among them, the Flaviviruses dengue (DENV) and West Nile (WNV) cause regular outbreaks with ... be mostly similar to the RdRps of the Flaviviridae members hepatitis C and bovine viral diarrhea virus, ... plays a central role. Viruses of the family Flaviviridae are important human and animal pathogens. Among them, ... be mostly similar to the RdRps of the Flaviviridae members hepatitis C and bovine viral diarrhea virus, ... multifunctional NS5 protein plays a central role. The Flaviviridae form a large family of single-stranded positive- ...
Tópico(s): Vibrio bacteria research studies
2007 - Elsevier BV | Journal of Biological Chemistry
Thomas S. Postler, Martin Beer, Bradley J. Blitvich, Jens Bukh, Xavier de Lamballerie, Jan Felix Drexler, Allison Imrie, Amit Kapoor, Galina G. Karganova, Philippe Lemey, Volker Lohmann, Peter Simmonds, Donald B. Smith, Jack T. Stapleton, Jens H. Kuhn,
... genus and species nomenclature within the virus family Flaviviridae along with reasons for these changes. First, it ... same word stem “flavi” in the taxon names Flaviviridae and Flavivirus; these terms could either have referred to all viruses classified in the family Flaviviridae or only to viruses classified in the included ... we outline the revised taxonomy of the family Flaviviridae as approved by the ICTV in April 2023.
Tópico(s): Insect Pest Control Strategies
2023 - Springer Science+Business Media | Archives of Virology
Gisa Gerold, Janina Bruening, Bettina Weigel, Thomas Pietschmann,
... will discuss protein interactions of members of the Flaviviridae family, which are small enveloped RNA viruses. Dengue ... virus belong to the most prominent human pathogenic Flaviviridae With a genome of roughly ten kilobases encoding only ten viral proteins, Flaviviridae display intricate mechanisms to engage the host cell ... host proteins and how this knowledge helps elucidate Flaviviridae infection. We will specifically address the protein composition ... will give a perspective on future challenges in Flaviviridae interaction proteomics and why we believe these challenges ...
Tópico(s): Animal Disease Management and Epidemiology
2017 - Elsevier BV | Molecular & Cellular Proteomics
Mini Kapoor, Luwen Zhang, Murali Ramachandra, Jingo Kusukawa, K.E. Ebner, R. Padmanabhan,
... virus type 2, a member of the family Flaviviridae, encodes a single polyprotein precursor consisting of 3391 ... virus type 2, a member of the family Flaviviridae, encodes a single polyprotein precursor consisting of 3391 ... nitrilotriacetic acid. a member of the family of Flaviviridae, has a single-stranded RNA genome of positive- ... Schlesinger S. Schlesinger M.J. The Togaviridae and Flaviviridae. Plenum Publishing Corp., New York1986: 327-365Crossref Google ... Schlesinger S. Schlesinger M.J. The Togaviridae and Flaviviridae. Plenum Publishing Corp., New York1986: 279-326Crossref Google ...
Tópico(s): Insect Resistance and Genetics
1995 - Elsevier BV | Journal of Biological Chemistry
Jack T. Stapleton, Steven K. H. Foung, A. Scott Muerhoff, Jens Bukh, Peter Simmonds,
... In 1995, two new members of the family Flaviviridae, named GBV-A and GBV-B, were identified ... been assigned to a genus within the family Flaviviridae. Based on phylogenetic relationships, genome organization and pathogenic ... members of a fourth genus in the family Flaviviridae, named Pegivirus (pe, persistent; g, GB or G). ...
Tópico(s): Influenza Virus Research Studies
2010 - Microbiology Society | Journal of General Virology
Jonathon C.O. Mifsud, Spyros Lytras, Michael R. Oliver, Kamilla Toon, Vincenzo A. Costa, Edward C. Holmes, Joe Grove,
... is a fragmentary understanding of glycoproteins within the Flaviviridae 2 , a large virus family that include pathogens ... structure prediction to survey glycoproteins across the entire Flaviviridae . We find class II fusion systems, homologous to ... shaped the diverse virology and ecology of the Flaviviridae .
Tópico(s): Viral Infections and Vectors
2024 - Nature Portfolio | Nature
Anastasia Latanova, Elizaveta Starodubova, В. Л. Карпов,
Members of the Flaviviridae family are posing a significant threat to human health worldwide. Many flaviviruses are capable of inducing severe inflammation in humans. Flaviviridae nonstructural proteins, apart from their canonical roles in ... the last known data on the role of Flaviviridae nonstructural proteins in molecular mechanisms of triggering inflammation, ...
Tópico(s): Viral Infections and Vectors
2022 - Multidisciplinary Digital Publishing Institute | Viruses
Yiqiao Li, Magda Bletsa, Zafeiro Zisi, Ine Boonen, Sophie Gryseels, Liana E. Kafetzopoulou, Joanne P. Webster, Stefano Catalano, Oliver G. Pybus, Frederik Van de Perre, Haotian Li, Yaoyao Li, Yuchun Li, Alexei V. Abramov, Petros Lymberakis, Philippe Lemey, Sébastian Lequime,
... EVEs deriving from members of the viral family Flaviviridae, an important group of viruses including well-known ... attesting to an ancient origin of pestiviruses and Flaviviridae in general. Moreover, we provide the first description of Flaviviridae-derived EVEs in mammals even though the family ... the ancient evolutionary history of pestiviruses and the Flaviviridae family in general.
Tópico(s): Animal Disease Management and Epidemiology
2022 - Oxford University Press | Molecular Biology and Evolution
Nabeel Alzahrani, Ming-Jhan Wu, Saravanabalaji Shanmugam, MinKyung Yi,
The Flaviviridae virus family is classified into four different genera, including flavivirus, hepacivirus, pegivirus, and pestivirus, which cause significant ... certain signal peptidase processing site(s) in different Flaviviridae viral structural protein precursors display suboptimal cleavage kinetics. ... review focuses on the recent progress regarding the Flaviviridae virus genus-specific mechanisms to downregulate signal peptidase- ...
Tópico(s): Hepatitis C virus research
2020 - Multidisciplinary Digital Publishing Institute | Viruses
Zhenzhen Zhang, Rong Liang, Yi‐Ping Li,
... variety of natural and diseased processes. Infections of Flaviviridae viruses trigger oxidative stress, which affects both the ... tick-borne encephalitis virus (TBEV) as representatives of Flaviviridae viruses and we summarize the mechanisms involved in ... the pathogenic mechanisms of oxidative stress induced by Flaviviridae viruses and highlight the relevance of autophagy and ...
Tópico(s): Viral Infections and Vectors
2019 - Hindawi Publishing Corporation | Oxidative Medicine and Cellular Longevity
Produção Nacional
... virus disease. Clinical Summary•The genus Flavivirus, family Flaviviridae, comprises approximately 73 viruses. The majority of the ... glomerulonephritis, and thrombotic microangiopathy. •The genus Flavivirus, family Flaviviridae, comprises approximately 73 viruses. The majority of the ... glomerulonephritis, and thrombotic microangiopathy. The genus Flavivirus, family Flaviviridae, comprises approximately 73 viruses with numerous common aspects, ... L.R. Marfin A.A. Shifting epidemiology of Flaviviridae.J Trav Med. 2005; 12: S3-S11PubMed Google ...
Tópico(s): Malaria Research and Control
2019 - Elsevier BV | Advances in Chronic Kidney Disease
Christopher J. Neufeldt, Mirko Cortese, Eliana G. Acosta, Ralf Bartenschlager,
... viral replication and antiviral therapies. Members of the Flaviviridae virus family comprise a large group of enveloped ... of flaviviruses. Although the fundamental replication strategy of Flaviviridae members is similar, during the past few years, ... Review, we discuss the current understanding of how Flaviviridae viruses manipulate and usurp cellular pathways in infected ...
Tópico(s): Viral Infections and Vectors
2018 - Nature Portfolio | Nature Reviews Microbiology
Quentin Nevers, Isaac Ruiz, Nazim Ahnou, Flora Donati, Rozenn Brillet, Laurent Softic, Maxime Chazal, Nolwenn Jouvenet, Slim Fourati, Camille Baudesson, Patrice Bruscella, Muriel Gelin, Jean‐François Guichou, Jean‐Michel Pawlotsky, Abdelhakim Ahmed‐Belkacem,
Although members of the Flaviviridae display high incidence, morbidity, and mortality rates, the development of specific antiviral drugs for each virus is unlikely. Cyclophilins, a ... inhibited the replication of other members of the Flaviviridae family with higher 50% effective concentrations (EC50s) than ... drugs with the potential for broad-spectrum anti-Flaviviridae activity as well as an invaluable tool to ...
Tópico(s): HIV Research and Treatment
2018 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
Peter Simmonds, Paul Becher, Jens Bukh, Ernest A. Gould, Gregor Meyers, T P Monath, Scott Muerhoff, Alexander G. Pletnev, Rebecca Rico-Hesse, Donald B. Smith, Jack T. Stapleton,
The Flaviviridae is a family of small enveloped viruses with RNA genomes of 9000–13 000 bases. Most infect ... Viruses (ICTV) report on the taxonomy of the Flaviviridae , which is available at www.ictv.global/report/flaviviridae .
Tópico(s): Animal Disease Management and Epidemiology
2017 - Microbiology Society | Journal of General Virology
Navaneethan Palanisamy, Dario Akaberi, Johan Lennerstrand,
Viruses belonging to the Flaviviridae family have been an important health concern for humans, animals and birds alike. No specific treatment is available yet for ... of viruses included in different genera of the Flaviviridae family, as we know that the sequence similarity ... Using available NS3 protease crystal structures of the Flaviviridae family, our preliminary results have shown that the ...
Tópico(s): HIV Research and Treatment
2017 - Elsevier BV | Molecular Phylogenetics and Evolution
... PubMed Scopus (28) Google Scholar]). Viruses from the Flaviviridae family, including flaviviruses, pestiviruses, and hepaciviruses (principally hepatitis ... respectively.View Large Image Figure ViewerDownload (PPT) The Flaviviridae family contains four genera: flavivirus, pestivirus, pegivirus (GB ... important insights on viral evolution. Viruses from the Flaviviridae family each have similar genetic organizations, coding strategies, ...
Tópico(s): Influenza Virus Research Studies
2014 - Elsevier BV | Trends in Microbiology
Dimitriοs Vlachakis, Vassiliki Lila Koumandou, Σοφία Κοσσίδα,
... represent very promising antiviral targets. Viruses of the flaviviridae family are the causative agents of many common ... fever. As there is currently no available anti-Flaviviridae therapy, there is urgent need for the development ... Herein, we report the complete phylogenetic analysis across flaviviridae alongside a more in-depth evolutionary study that ...
Tópico(s): Hepatitis C virus research
2013 - PeerJ, Inc. | PeerJ
Neeraj Singh, Marilyn E. Levi,
... single-stranded RNA arbovirus that belongs to the Flaviviridae family, which also includes St. Louis Encephalitis (SLEV), ... America 44. WNV and SLEV are the only flaviviridae endemic in the United States 45 with WNV ... WNV serologies is the cross reactivity with other flaviviridae, such as St. Louis and Japanese Encephalitis and ... microsphere assays that are specific to the different flaviviridae. For specific confirmation, plaque reduction neutralization testing (PRNT) ...
Tópico(s): Viral Infections and Vectors
2013 - Elsevier BV | American Journal of Transplantation